Why correcting inhibited bile or constipation is not always so simple.

I am asked pretty often how to correct inhibited bile flow. This is not and easy question to answer and there are many things that can cause it. I will show you how complex of a question that is. There are a huge number of things that can effect bile production. It is probably one of the most difficult things to correct because there is a lot of questions that need answered to know what is causing to occur and it is different in each individual. If bile is inhibited then gall bladder issues will pretty much be a given. A person with issues in bile flow will have trouble digesting food it will sit like a brick in their stomach and ferment. If they have motility issues the bile they do produce will enter the stomach so they would still appear to be deficient in bile. The way to break the cycle is to correct what is causing it but it is not simple figuring out why. So here is the list of things that can cause inhibited bile flow or inhibited motility (constipation). This is by no means a complete list. This is also why there are many question that need answered when constipation is chronic.

High estrogen levels.

High copper levels

Low serotonin levels.

High noadrenaline levels or high adrenal hormone levels also connected to copper.

Low substance P levels.

Inflammation

candida overgrowth or gut dysbiosis

low cholesterol or issues with cholesterol metabolism

inhibited vitamin D receptor or low vitamin D levels.

Inhibited retinoid x receptor

lactase deficiency which cause lactose intolerance and is a sigh of a deficiency in saccharmyces boulardii.

Low amylase

Poor mucous membrane health

lipase deficiency

excess pancreatic polypeptide

pancreatic elastase deficiency

hypothalamus injury or issues.

High insulin levels

Nutrient deficiency or issues with protein metabolism especially taurine

electrolyte deficiencies

Low cysteine levels

low vasoactive peptide levels

high glucagon levels

high secretin levels

high somatastatin levels

Gastin hormone from low histamines

low bombesin levels

high cholecystolinin levels

infection

leaky gut

issues with sulfation or high sulfite levels

bile duct obstruction

T cell imbalance

high oxalate levels

High Lysolecithin found in processed foods.

High COX-2 levels

Not getting enough medium chain fatty acids.

High sulfur digesting or methane producing bacteria levels , dysbiosis

Decreased COMT activity

High folic acid levels which is not the same as folate

Low betaine homocysteine S-mthyltransferase levels which leads to hypothyroidism

choline deficiency or issues with choline metabolism

Deficiency in Akkermansia Muciniphila

Issues with lipid metabolism

Issues with the Kreb’s cycle also known as the citric acid cycle.

Low HNF4a levels

High B-hydroxybutyrate levels caused by low oxaloacetate levels.

Hydrolase synthase deficiency

alkaline phosphatase deficiency which inhibits bile and decreases good gut bacteria levels in the gut increasing the bacteria that inhibit bile.

Inhibited FXR receptor

decreased motilin

Inhibited ABCB4

Inhibited CYP7a1 enzymes

pyruvate carboxylase deficiency

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