I am asked pretty often how to correct inhibited bile flow. This is not and easy question to answer and there are many things that can cause it. I will show you how complex of a question that is. There are a huge number of things that can effect bile production. It is probably one of the most difficult things to correct because there is a lot of questions that need answered to know what is causing to occur and it is different in each individual. If bile is inhibited then gall bladder issues will pretty much be a given. A person with issues in bile flow will have trouble digesting food it will sit like a brick in their stomach and ferment. If they have motility issues the bile they do produce will enter the stomach so they would still appear to be deficient in bile. The way to break the cycle is to correct what is causing it but it is not simple figuring out why. So here is the list of things that can cause inhibited bile flow or inhibited motility (constipation). This is by no means a complete list. This is also why there are many question that need answered when constipation is chronic.
High estrogen levels.
High copper levels
Low serotonin levels.
High noadrenaline levels or high adrenal hormone levels also connected to copper.
Low substance P levels.
Inflammation
candida overgrowth or gut dysbiosis
low cholesterol or issues with cholesterol metabolism
inhibited vitamin D receptor or low vitamin D levels.
Inhibited retinoid x receptor
lactase deficiency which cause lactose intolerance and is a sigh of a deficiency in saccharmyces boulardii.
Low amylase
Poor mucous membrane health
lipase deficiency
excess pancreatic polypeptide
pancreatic elastase deficiency
hypothalamus injury or issues.
High insulin levels
Nutrient deficiency or issues with protein metabolism especially taurine
electrolyte deficiencies
Low cysteine levels
low vasoactive peptide levels
high glucagon levels
high secretin levels
high somatastatin levels
Gastin hormone from low histamines
low bombesin levels
high cholecystolinin levels
infection
leaky gut
issues with sulfation or high sulfite levels
bile duct obstruction
T cell imbalance
high oxalate levels
High Lysolecithin found in processed foods.
High COX-2 levels
Not getting enough medium chain fatty acids.
High sulfur digesting or methane producing bacteria levels , dysbiosis
Decreased COMT activity
High folic acid levels which is not the same as folate
Low betaine homocysteine S-mthyltransferase levels which leads to hypothyroidism
choline deficiency or issues with choline metabolism
Deficiency in Akkermansia Muciniphila
Issues with lipid metabolism
Issues with the Kreb’s cycle also known as the citric acid cycle.
Low HNF4a levels
High B-hydroxybutyrate levels caused by low oxaloacetate levels.
Hydrolase synthase deficiency
alkaline phosphatase deficiency which inhibits bile and decreases good gut bacteria levels in the gut increasing the bacteria that inhibit bile.
Inhibited FXR receptor
decreased motilin
Inhibited ABCB4
Inhibited CYP7a1 enzymes
pyruvate carboxylase deficiency
