Feel bloated, flatulence smell like rotten eggs?

This is not medical advice, I am posting this for educational and informational purposes.

 

 

Boating, stinky flatulence that smell like rotten eggs, abdominal pain, constipation or diarrhea, Bile acid refux, headache, fatigue, muscle pain?

If we have to many Hydrogen Sulfate producing bacteria it can negatively impact our health. This occurs if we eat GMOs which are high in glyphosate and glufonisate or from taking antibiotics for too long. H2S inhibits butyrate oxidation in colonic epithelial cells which causes many health problems even psychosis. This also compromises the intestinal barrier function which causes an energy deficit.

Bismuth blocks H2S production ,Lactobacillus Plantarum and Saccharomyces Cerevisiae reduces Desulfovibrio , and other producers of H2S but there are others that produce it. Glycomacropeptide found in whey protein reduces Desulfovibrio bacteria. Lactoferrin and lactulose have been shown to reduce sulfur digesting bacteria. Galacto-oligosaccharide has been found to increase the good microbes that reduce the sulfur digesting and methane producing bacteria. Fiber also helps reduce sulfur digesting bacteria.

High H2S causes increased inflammation, increased Reactive Oxygen Species, and increase neutrophils in order to convert H2S to thiosulfate. If thiosulfate levels get too high in the blood it can cause a type of anemia called Heinz Body anemia. If a person is G6PD deficient this will make their symptoms much worse. Low thiosulfate levels in the urine could indicate low or inhibited Thiolmethyltransferase. High thiosulfate in the blood can also be caused by excess garlic consumption.

There are urine test for thiosulfate. High levels can indicate high H2S producing bacteria in the gut or it can indicate a deficiency in Thiolmethyltransferase. This can lead to CoQ10 deficiency and NADPH deficiency. This can also lead to inhibited sulfide oxidation which can impair fatty acid oxidation. This also causes glutathione to become depleted. You can also test the urine for H2S.

This can effect each differently depending on the level of H2S. They can either become constipated or get diarrhea. It can result in inflammatory bowel, pouchitis, halitosis, fatty acid deficiency from inhibited fatty acid oxidation and malabsorption. Lower H2S stimulates intestinal contraction and higher levels causes relaxation of the intestines.

High sulfur foods and meat increase H2S levels if the sulfur digesting gut microbiota are high. Most fats can also increase H2S and medium chain fatty acids are usually the best to consume when there are high sulfur digesting bacteria levels. Many of our processed foods contain sulfur as a preservative.

In a lactulose test if the levels of methane and hydrogen are not high then it is most likely dysbiosis caused by high sulfur digesting bacteria levels.

H2S cysteine activates GLUT increasing the transport of glucose into the cell. The excess hydrogen sulfide in the body will cause a person to develop sulfur intolerance. High sulfur foods will cause a reaction or they will become ill.

Polyphenols reduce the H2S producing bacteria. Wine and green tea in moderation can reduce the H2S producing bacteria.

The bacteria that can be found in the stool that are sulfur digesting and produce high levels of H2S are Desulfovibrio, Streptococcus, Enterococcus, and Prevotella.

Often times when a person has dysbiosis they will tell them to avoid starch but resistant starch reduces the H2S producing microbiota. Butyrate found in butter helps reduce the effects of high H2S. We can increase our Butyrate by taking a butyrate producing probiotic and making sure they get the starches and sugars they need.

High H2S levels increases Trimethylsulfonium in urine. High trimethylsulfonium levels can effect indolethylamine-N-methyl-transferease enzymes which is needed for the methylation of thiols. When this is effected It can effect hormones throughout the body. Glyphosate uses a sulfonium salt which could increase the negative effects to add gasoline to the fire glyphosate kills the microbiota that help keep sulfur digesting bacteria levels down.

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Digestion probably more then you wanted to know. Enzymes and bile and stuff.

This is not medical advice I am posting this for informational and educational purposes.

This is not done I have a lot to add to it but I am kind of burned out. I will finis it later after I take a break.

Gastrointestinal motility and digestive enzymes.

This is mostly on bile but I wanted to cover the other areas of digestion before I covered bile.

Most know how digestion works but we need a refresher. When we chew our food it is mixed with saliva which has some digestive enzymes in it. When we swallow it is propelled down the esophogus where it is mixed with enzymes and gastric acid. The end result is called chyme. The chyme is pushed into the small intestine (duodenum). Many will ask me how to increase bile production but doing so could cause more harm then good. The problem causing the inhibited bile flow needs to be addressed. For example a dam can only hold so much water. If there is more water then the dam can hold it will flood over the top. Adding more water to the dam adds to the problems and could break the dam. When there is a blockage causing bile flow to be inhibited then increasing bile would be like adding water to a dam that is already overflowing. Most health issues mentioned in this article I have discussed elsewhere on my blog.

Peristalsis is the movement of food through the digestive system. It is the cause of the gurgling sound you hear when you are hungry or digesting food. Usually you cannot hear it. I do not know why but I and my friends experienced this. As we healed our digestive system you could feel the food moving and the sounds of digestions were very loud. As we healed they became quieter and quieter.

In the small intestine the food is combined with bile and pancreatic enzymes to break it down further and for nutrient absorption. The smooth muscle in the intestines are ring shaped and alternate between contracting and relaxing. This causes the food to move slow enough through the digestive tract for it to be broke down and for the nutrients to be absorbed. The neurons are stimulated by acetylcholine, and substance P to get them to contract. Nitric oxide, vasoactive peptide and ATP relax the muscles. This causes a motion that moves the food through the digestive tract and occurs the most in the small intestine. There are health issues that can cause a high acetylcholine and high substance P levels. High noradrenaline reduces substance P which can interfere with intestinal motility and can lead to constipation. High estrogen levels can inhibit substance P. High substance P levels can cause inflammation and lead to inflammatory bowel disease. There are health issues that can cause low acetylcholine and low serotonin levels. This also will cause a loss of motility leading to constipation. An imbalance in our immune system can cause bile flow to be inhibited. Estrogen inhibits bile flow and progesterone pormotes bile flow. This causes the liver and thyroids to become sluggish. This can also lead to interstitial cystitis. All the above mentioned things can inhibit receptors and throw hormones out of balance. If not addressed it will become chronic and start a cycle that is difficult to break and can take months to years to heal from.

https://www.selfhacked.com/blog/substance-p-roles/

If the gurgling in the gut is excessive and there is cramping, abdominal pain, and possibly nausea and vomiting it could indicate slow gut motility or a blockage. This can be caused by intestinal damage, hormone imbalance, inflammation in the intestines, dysbiosis, candida overgrowth, a deficiency in certain gut microbiota, slow or inhibited bile. This causes gas, bloating, and distention (inflammation in the gut). If we have a T cell imbalance or high B cell levels this can also cause it. If not addressed it can result in a decline of intestinal health our the health of the body. High histamines can cause inflammation that can cause blockage. We do not want to inhibit them because histamines are needed to stimulate gastric acid. It is best to work on reducing them.

If the digestive system is injured and we do not give it the things needed for it to heal then it loses the ability to sense nutrients and food that has entered it so it cannot respond to them. The longer it goes like this the worse it gets and the longer it will take to heal.

Bile acid is needed for the healthy brown fat to be produced. Bile acid is synthesized form cholesterol. Excess oxidative stress or inflammation in the liver can cause low cholesterol levels or can inhibit it’s production which would prevent the bodies ability to produce bile properly. This can also cause bile to become inhibited. When this happens bile production is reduced and it becomes thick. Phosphatydylcholine is needed to store bile in the gallbladder. I have found most who have problems with choline metabolism have benefited from sunflower seed oil. Excess oxidative stress can cause methionine and choline to become depleted. This inhibits the bodies ability to produce bile.

Enzymes.

If you are deficient in certain enzymes often times there are plants you can consume that will helps digest foods that require those enzymes.

Lactase- (B-Galactosidase)- deficiency causes lactose intolerance. It breaks down Lactose down to glucose and galactose. Damage in the gut can cause it to not be reabsorbed. If this happens the gut microbiome will break it down causing gas and bloating. Those who are lactose intolerance will usually also be intolerant of FODMAPS until they get their gut healed enough to correct the malabsorption issues. Those who have malabsorption issues may benefit from taking Lactase when consuming dairy products. Saccharmyces Boulardii has been found to increase enzyme function in those with Lactose and FODMAP intolerance. If a person is lactose intolerant if they avoid dairy products while supplementing galactooligosaccaride for about a month, it has been found to increase Lactose metabolizing bacteria which prevents the bloating and ill effects of lactose. Also slowly introducing dairy into the diet a little at a time can increase the gut microbes that produce lactase. That would prevent a reaction to lactose also.

Alpha-galactosidase- helps break down digested fats and saccharides a deficiency causes lysosomal storage diseases. If defficient in Alpha-Galactosidase when eating fiber and high sulfur foods a person will develop gas and bloating. Those who have a deficiency in Alpha-galcatosidase will be intolerant to complex carbohydrates and may be intolerant to gluten. Beans will be a problem for a person lacking this. Infection can cause A-gal to be inhibited from the LPS produced. Inducing autophagy can testore A-gal. Tick born illness can cause autoimmune disease that can cause the body to make antibodies against a-gal. Balancing the immune system is very important. If not addressed it can lead to a sensitivity to meat.

Things that help with lysosomal storage disease should help with this. https://iamajuicer.wordpress.com/2018/08/21/things-that-may-help-with-lysosomals-storage-disease/

Sucrase- secreted in the small intestine. Catalyzes sucrose , fructose, and maltose. A deficiency will cause lactose intolerance, gas , bloating and diarrhea when things containing sucrose are consumed. Inflammation can cause it’s excretion into the small intestine to be inhibited. Sucrase is also known as invertase. Thyroid hormones and corticosterone stimulate sucrase and maltase. Inflammation and intestinal damage will decrease it’s secretion. High CD8 T cell levels inhibit Sucrase. I have posted on balancing T cells.

Amylases-work with other enzymes to break down polysaccharides. It is the major form of amylase found in humans and breaks down starch to maltose and dextran. It prevents bacteria from producing biofilms by breaking them down. It is secreted in saliva and from the pancreas.

endopeptidase (enterokinase) that breaks down proteins into smaller peptides (it is a protease) It is produced in the stomach and is one of the main digestive enzymes. It transforms trypsinogn into trypsin. procarboxypeptidase into the active enzyme carboxypeptidase which is involved in the maturation of proteins produced. Carboxypeptidase is also involved in enzyme and hormone production throughtout the body. It is produced in the mucus membrane showing the importance of restoring the health of the mucous membrane. This can result in protein and enzyme deficiencies in the body.

Trypsinogen- is the precursor form of trypsin it is found in pancreatic juice that is released in the small intestine. Trypsinogen is activated by the protease enteropeptidase which is produce by the mucus of the duodenum. Trypsin breaks down proteins to ammino acids.

Chymotrypsinogen- precursor for chymotrypsin. It is activated by trypsin.

Pancreatic Lipase- It is secreted into the small intestine in it’s completed form. But it only becomes effective in the presence of colipase which is a co-enzyme.

Phospholipase-converts lipids(fats) to phospholipids.

Lipase-breaks down triglycerides to fatty acids and glycerol. Deficiency causes a lack of fats needed by the body and fats in stools. Lipase also protect the body from parasites and pathogens. If deficienct a person will suffer from malabsorption. There are microbe derived lipases that have been shown to be effective for Lipase deficiency.

Na+ Taurocholate Cotransporting Polypeptide (NTCP) is used by the liver to extract BA returning to the lever through the portal vein. Should not be stimulated in those with cholestasis it can damage the liver. A deficiency causes muscle weakness. If it is inhbited bile salts can build up in the liver resulting in liver damage. This also results in an increase in blood levels of bile acids.

Pancreatic Polypeptide self-regulates pancreatic secretion activities. It’s secretion is increased from protein consumption, fasting, exercise, and is decreased by glucose and somatostatin. It can inhibit gallblader contractions and pancreatic exocrine secretion.

Pancreatic Elastase – help finish breaking down foods. If there is excess oxidative stress , inflammation or immune imbalance that effects the pancreas it can inhibit pancreatic enzyme secretion. They usually test for this enzyme in stool to see if the pancreas is functioning properly.

Digestive hormones.

Most of these hormones are effected by our brain especially the hypothalamus. If we have endotonins, heavy metals , glyphosate or other toxins that effect the brain then our digestion will be effected which further effects our brains. The hormone imbalance causes mental issues. They can be corrected if you address what is causing the imbalance. Many will take medications, which only treat the symptoms. Most medications for those types of things effect digestive hormones adding to the problem. Then when a person starts correcting the problem their mental issues become worse because of the drugs they are taking and the body starting to function correctly will swing hormones in the other direction. When the digestive system is damaged our cells that produce hormones become less numerous. We must try and protect the so healing can begin. Also nerve cells become less numerous which makes our bodies digestive responses to be much lower. Regular and electric acupuncture have been shown to help restore normal hormone levels. Bile acid also regulates lipid and glucose homeostasis. If bile acid become inhibited Thyroxine (T4) levels increase and Tiiodothyronine (T3). Low T3 levels inhibits oxidation which is needed to use lipids and cholesterol in the body. This will cause low LDL levels and high HDL level. Low T3 levels inhibits the bodies ability to synthesize proteins. Insulin loses it’s ability to inhibit glucogenesis. This cause glycolysis to be inhibited. This also effects the heart and can cause heart palpitations. High T4 levels can cause a decrease in serotonin.

Ampulla of Vater blocakge– inflammation, oxalates, toxins, infection or damage in the body can lead to pancreatic enzymes building up causing the pancreas to digest itself.

If you have blockage inhibiting enzyme secretion I would not advice stimulating the secretion until the health problems causing the blockage have been addressed.

When we have metabolic issues, inflammation or any other of the health issues I have describe these enzymes can be effected. Especially if we have damage to our digestive system.

Serotonin – (5-HT) regulates gut motility. It is produced in the mucosa of the gut. It increases peristalsis (movement of food through digestive tract). It has been found to be low in those with inflammatory bowel diseases. A deficiency can cause gastroparisis and bile reflux. It also stimulates adenylyl cyclase which is involved in cell signaling throughout the body. Most drug agonist of the 5-HT receptors damage the liver and heart. Acupunture stimulates serotonin. There are some disorders which inhibits 5-HT from exiting the cells. This causes a build up in the cells and a person will be senstitive to 5-HT but would still have symptoms of 5-HT deficiency.

Motilin – triggered by fasting, and fatty foods. Controls peristalsis by stimulating smooth muscle contraction and relaxation to coordinate the movement of food through the digestive tract. The antibiotic erthromycin stimulates motilin. Motilin had been found to be low in those with inflammatory bowel diseases. Acupuncture increases motilin. Motilins effects are influenced by PH. Low PH motilin inhibits gastric motility at higher PH it stimulates gastrointestinal motility. Food intake slows the production of motilin. Insulin also inhibits the secretion of motilin.

Reflux can be cause by bile issues in two ways. If there is a blockage a person could experience bile acid reflux. If there is insufficient bile production the the acid from the chyme does not get neutralized by the bile and will cause acid reflux. L-taurine and betaine also known as TMG helps with bile production. Cysteine is also needed and taking NAC (N-acetylcysteine) about three times a week has been found to help. If it is taken more then that the benefits are lost.

Gastric Inhibitory Peptide – triggered by glucose and fatty foods. Decreases gastric emptying and stimulates the release of insulin. It promotes fat storage.

Vasoactive Peptide – increases blood flow to the gut, supplies eleyctrolytes to pancreatic enzymes and bile.

Guanylin – causes secretion of chloride , decreases absorption of water from the gut. It prevents the sodium levels from the body from getting too high by inhibiting salt absorption and by stimulating the secretion of bicarbonate and chloride.

Glucagon – glucagon supresses CYP7A1 which reduces bile production. This can lead to insulin resistance and glucose intolerance. Glucagon prevents blood sugar levels from getting too low. It is involved in gluconeogenesis which produces glucose form proteins.Glucagon also breaks down fat stores in the blood stream. Excess glucagon leads to diabetes and thrombosis.

Glucagon Like Protein-1 (GLP-1) Whey protein increases GLP-1, glucose also stimulates GLP-1. Slows down digestion. It increases the size and health of pancreatic B cells. Stimulates brain repair. It’s release is stimulated by TGR-5. GLP-1 is involved in appetite suppression and glucose homeostasis. Low levels causes glucose deficiency. Carbohydrates and elevated blood levels of proteins helps stimulate glucagon . If we are deficient in glucagon glycogen can build up in the livers. It brings down glycogen in the liver by breaking it down to produce glucose. Somatostatin inhibits glucagon production. Excess glucagon cause weight loss and deficiency causes weight gain. Fasting stimulates glucagon production.

Secretin- helps regulate water homeostasis in the body, helps regulate the PH of the small intestine by gastric acid. Secretin inhibits gastic acid production and stimulates the production of bicarbonate. Secretin also stimulates bile production. It is produced mainly in the mucosa of the small intestine and jejunum. It is release from the low ph caused by chyme entering the small intestine.

Secretin deficiency causes a loss of neural progenitor cells. Progenitor cells are similar to stem cells. Since secretin increases neural progenitor cells it helps with autism, motor coordination and improves memory. Secretin helps with asthma by acting as a bronchorelaxer. Secretin reduces symptoms of pancreatitits.

In order to function properly levels of cholecystokinin and insulin need to be normal. If they are dis-regulated it effects secretin levels. It also stimulates polyamines in the pancrease which is needed for cell growth. Polyamines also regulate ion channels including the NMDA recemptors, AMPA receptors and potassium channels. Excess polyamines can cause the blood brain barrier to become more porous. Showing the importance of secretin homeostasis. When H Pylori in in it’s pathogenic form it will cause a secretin deficiency. Secretin promotes the production of mucus. A decrease in secretin decreases the function of angiotensin 2. Secretin increases thirst. Secretin increases the feel good hormone oxytocin.

Now the bad if a person has bile blockage like cholestasis it can cause liver damage. I discuss things that can help with that at the end of this blog post. Secretin causes Zollinger-Ellison syndrome to worsen.

High levels of somatostatin inhibits secretin.

Cholecystokinin- stimulates the release of digestive enzymes and bile from the pancrease and bladder. Whey protein stimulates CCK. Fat intake also stimulates CCK. A deficiency in CCK causes malabsorption and can lead to Type 1 diabetes. Damage to the mucus membrane can cause a deficiency. This can also be caused by autoimmunity. This is where a dilemma occurs. High levels of bacteroidetes or high levels of methane producing bacteria can inhibit CCK. Protein stimulates CCK. I believe working on bile blockage and then once that is corrected increasing bile flow first to reduce the bacteroidetes levels and methane producing bacteria then adding protein into the diet once they are reduced would most likely correct the problem along with restoring the health of the mucus membrane.

Intrinsic Factor-important in the absorption of vitamin B12. Often times B12 deficiency is caused by a lack of the microbiota that produce B12 but is mistakenly attributed to and intrinsic factor deficiency.

Haptocorin-binds to B12 in our food protecting it from our gastric acid so it can survive the stomach. It is found in our saliva. This shows the importance of making sure we chew our food very well.

Gastrin- hormone that stimulates gastric acid secretion. It is released from the pariental cells in the stomach. It also aids in gastric motility. Elevated gastrin can cause hypergastrinaemia. Low levels can cause hypergstrinaemia. Infection can effect gastrin levels and so can histamines. Histamines are needed for Gastrin stimulation if histamine levels are too low the we will not produce enough stomach acid. If they are too high then we can get acid reflux. If someone is not producing enough acid then they most likely have low histamines and would benefit from fermented foods and aged meats which are high histamine.

Gastric inhibitory polypeptide- an inhibiting hormone of the secretin family. It stimulates insulin secretions based on how much glucose is present. It stimulates glucagon secretion and fat accumulation. It is found in intestinal mucus, small intestine, and jejunum of the gastrointestinal tract. Has many other functions throughout the body including bone growth.

Vasoactive intestinal peptide- serves functions throughout the body but relaxes smooth muscles in the trachea, gall bladder and stomach.

Bombesin- stimulates gastrin release from the pancrease. It also stimulates adrenal and pituitary hormones. It increases the thickness of the mucus membrane. It modulates the neural firing rate in the intestines so is involved with gastrointestinal motility.

Somatostatin reduces histamines which will reduce the gastric acid stimulating effects of histamine. In those with inflammatory bowel issues somatostatin in usually very high. Acupuncture has been shown to reduce somatostatin. Most lactobacillus bacteria will reduce somatostatin. Somatostatin prevents the over production of certain hormones in the body. If there is excess somatistatin it will inhibit hormones especially insulin. Somatostatin inhibits glucose and fat absorption. It inhibits insulin and glucagon in the liver. It stimulates muscle contractions in the intestines speedingup transit times. Protein stimulates somatostatin.

Cholecystokinin, glucagon-like-peptide, gastrin-releasing peptide stimulate somatostatin.

Substance P, insulin, pancreatic polypeptide, and opioids inhibit somatostatin.

Excess somatostatin inhibits bone growth, disrupts sleep, and increases dopamine, norepinephrin and epinephrine.

High levels somatostatin will cause high thyroid hormone levels because it inhibits thyroid stimulating hormone which senses hormone levels and shuts them down if they get too high. This causes weight loss no matter how much a person consumes , flushing or hot flashes, and heart palpitations.

Insulin- breaks down blood glucose. Excess insulin can lead to cancer and many other health problems. Glycoproteins increase insulin. Whey protein increases insulin and reduces blood glucose levels. This is one that confuses me and makes me believe those with inflammatory bile have blockages. Many with inflammatory bowel have high insulin levels which stimulates CYP7A1 which should increase bile production and still they have low bile flow and often times CYP7A1 levels are low. It may be that inflammation is inhibiting the receptor.

Ghrelin-triggered during hunger or calorie restriction. Stimulates appetite. Whey proteins increases Ghrelin. Ghrelin is involved with gastric emptying.

Deacyl-ghrelin – DAG decreases gastric emptying, induces postprandial fullness and improves insulin sensitivity.

Peptide YY- secreted after eating it cancels out the effects of ghrelin.

Pheonixin – expressed in the hypothalamus, it stimulates appetite.

Peptide YY- produced in the gut where short chain fatty acids are produced. Proprionate and butyrate increase expression of Peptide YY. It reduces appetite. It is stimulated from the consumption of fiber from fruits and vegetagles. It also reduces pancreatic secretion.

Leptin – regulates body fat.

http://www.jnmjournal.org/journal/view.html?uid=1395&vmd=Full&

Bile Acids

Bile stimulates the secretion of electrolytes and water into the intestines which stimulates digestion. Biles acid stimulates the release of 5-HT. Those with inflammatory bowel diseases have been found to have high levels of bile acids Taurocholic Lithocholic Acid, Taurocholic acid and Taurocholic Deoxycholate.

Bile acid promotes liver regeneration by activiating BA recperors Farnesoid X receptor and G-Protein-coupled BA receptor1 (GPBAR1 or TGR5) . This shows the importance of bile acid homeostasis. Proper bile acid production is very important for maintaining a balanced gut microbiome.

There are many things that can inhibit bile production. Inflammation, toxins, metabolic issues, especially inhibited receptors involved with bile production. Infections can cause bile to become inhibited and so can the endotoxins they produce. If we develop leaky gut the LPS (lipopolysaccharide) which is produced by pathogens and our commensals can enter the blood stream. Our microbiome uses LPS to communicate with our bodies but when it gets into the blood stream it causes the same problems a pathogen would. We also have commensal microbes that break down LPS antibiotics and farm chemicals especially glyphosate and glufonisate can kill our gut microbiome. They modulate most organs in our bodies including our brains. They even modulate some of our genes. Without them we will not have an immune system and we cannot restore the body to homeostasis. Metabolic issues can cause acidosis or alkalosis which will also interfere with the propper function of our organs and causes a lot of damage which progresses and becomes more severe if the problems causing them are not addressed. Infection can also change the PH of the body. There is a myth that alkalizing the body will make us healthier. This is not true but it promotes things that are usually commensal like Candida and H Pylori to turn pathogenic. If a person has candida and H Pylori problems they most likely have high ammonia levels. This causes BH4 to become depleted increasing the ammonia levels even more. If not addressed they will start having problems eating high protein foods and high sulfur foods. Another thing that can cause blockage that effects bile flow is oxalates. They can be produced endogenously or we can get them exogenously. If we have leaky gut oxalates that are usually excreted in our feces can easily enter our blood stream. Also many will consume a lot of raw greens. Spinach and Kale are very high oxalate and can increase oxalates in the body. We have oxalate degrading microbiota and if antibiotics or farm chemicals in our food kills them our oxalate levels can indrease. I have posted on my blog on how to deal with those issues.

Bile, an aqueous solution produced and secreted by the liver, consists mainly of bile salts, phospholipids, cholesterol, conjugated bilirubin, electrolytes, and water.The liver cells are mostly hepatocytes. Bile travels through the liver in a series of ducts, eventually exiting through the common hepatic duct. Bile flows through this duct into the gallbladder where it is concentrated and stored. When stimulated by the hormone cholecystokinin (CCK), the gallbladder contracts, pushing bile through the cystic duct and into the common bile duct. CCK is usually deficient in those with inflammatory bowel disease. Cholecystokinin is released after a meal is consumed. It is stimulated by the production of stomach acid. It is secreted along with secretin. Secretin stimulates bicarbonate in response to the acid from the chyme that enters the small intestin, and It stimulates pancreatic enzymes and forces bile into the small intestine. If we do not produce enough stomach acid then Cholecystokinin is not released and our food will sit in our stomach and ferment. This causes and increase of either methane producing bacteria or sulfur digesting bacteria. Methane and sulfur digesting bacteria cause lower motility in the intestines slowly digestion even more. Bile is needed to stimulate the Vitamin D Receptor.

Simultaneously, the sphincter of Oddi relaxes, permitting bile to enter the duodenal lumen. Lumen is the space in a tubular shape. The hormone secretin also plays an important role in the flow of bile into the small intestine. By stimulating biliary and pancreatic ductular cells to secrete bicarbonate and water in response to the presence of acid in the duodenum, secretin effectively expands the volume of bile entering the duodenum. In the small intestine, bile acids facilitates lipid digestion and absorption. Bile is needed to absorb many nutrients especially lipid (fat) soluble vitamins like Vitamin D, Vitamin E, , Vitamin A and Vitamin K. Only approximately 5% of these bile acids are eventually excreted. The majority of bile acids are efficiently reabsorbed from the ileum, secreted into the portal venous system, and returned to the liver in a process known as enterohepatic recirculation. Ileum is the final section of the small intestine.

If bile becomes inhibited it inhibits the vitamin D receptor further inhibiting bile production and adding to the problem because cholesterol production and conversion becomes inhibited. This will make bile become sludgy leading to low bile flow which will increase estrogen levels and cause high unbound copper levels in the blood. Bitter herbs increase bile flow but the vitamin D receptor has to be addressed along with balancing the microbiome in the gut and healing the intestinal tract. Inflammation needs to be reduced , and prevent thrombosis. There are many things that can block the portal vein. The above mentioned things and also thrombosis can cause it. Thrombosis is blood clotting.

This is why I often times recommend grape seed extract and bacopa to people. It prevents thrombosis. Inflammation because endotoxins can cause thrombosis. Grape seed extract and bacopa reduce inflammation and prevent thrombosis. If thrombosis occurs in the portal vein it will effect the liver, pancrease, and digestive system. This causes pain in the stomach, bloating, inflammation, pancreatic pain, pain in the gallbladder. This can lead to death. Bile flow will become inhibited speeding up the progression of portal vein thrombosis. Those with hepatitis need to use hawthorne or something else. Resveratrol activates hepatitis.

portal vein thrombosis

gastrointestinal symptoms (ex: abdominal pain, nausea, vomiting, and diarrhea), fever and constitutional symptoms (ex: fatigue, malaise, and anorexia/weight loss) [3]. We can also find hepatomegaly with elevated liver enzymes and jaundice [3], when associated with liver abscess or cholangitis [2]. Laboratory tests usually demonstrate elevated markers of inflammation [2]

https://www.journalmc.org/index.php/JMC/article/view/3050/2378

If not addressed in time it can lead to portal hypertension. This results in brain swelling, abdominal swelling . Confusion, anemia and low white blood cell count.

https://my.clevelandclinic.org/health/diseases/4912-portal-hypertension

How Bile is Formed.

Bile is produced by hepatocytes, which is then modified by the cholangiocytes lining the bile ducts. The production and secretion of bile require active transport systems within hepatocytes and cholangiocytes in addition to a structurally and functionally intact biliary tree. If this becomes blocked by stones from poor bile production, oxalates or infection a person can develop choledocholithiasis. This will cause problems with the gall bladder, liver, kidneys and digestion. This can also lead pancreatic problems. The symptoms are upper abdominal pain, nausea and vomiting.

Initially, hepatocytes produce bile by secreting conjugated bilirubin, bile salts, cholesterol, phospholipids, proteins, ions, and water into their canaliculi (thin tubules between adjacent hepatocytes that eventually join to form bile ducts). Unconjugated bile is when heme is released during red blood cell break down, the remainder is converted to unconjugated hemoglobin. This form of bilirubin travels from the blood stream to the liver. If the liver cannot convert unconjugated to conjugated it will build up in the blood and a person will develop a yellow like glow. It is normally excreted through the intestines. If there is a rapid destruction of blood cells this can also happen. Infections, toxins, excess vitmin C and excess iron can cause the red blood cells to break down. Conjugated bilirubin is water soluble and if there is a blockage it will be excreted in the urine. Testing for high bilirubin in the urine can help identify blockage.

The canalicular membrane of the hepatocyte is the main bile secretory apparatus which contains the intracellular organelles, the cytoskeleton of the hepatocyte and carrier proteins. Fluctuations in cytosolic and organelle Ca2+ following glucagon or epinephrine stimulation play a major role in hepatic control of glucose production, bile fluid movement and excretion, fatty acid, amino acid and xenobiotic metabolism, protein synthesis and secretion, cell cycle and cell proliferation, among other functions. I discussed in some of my other post about autophagy. It can help issues like this.

The carrier proteins in the canalicular membrane transport bile acid and ions. Transporter proteins found within the canalicular membrane use energy to secrete molecules into bile against concentration gradients. The citric acid cycle is involved in providing the energy for this to occur. Mitochondrial disfunction and a loss of ATP can also interfere with this process. If this occurs cholestasis can occur causing a backup of bile and it can enter the blood stream. If the problem causing the obstruction is not addressed it can lead to fibrosis and vanishing bile duct syndrome. Symptoms are frequent itchy skin, elevated triglycerides, fat growths that appear under the skin. Drugs are often times the cause especially fluorquinolones.

Through this active transport, osmotic and electrochemical gradients are formed. When conjugated bile salts enter the canaliculus, water follows by osmosis. The electrochemical gradient allows for the passive diffusion of inorganic ions such as sodium. The most significant promoter of bile formation is the passage of conjugated bile salts into the biliary canaliculus. The total bile flow in a day is approximately 600 ml, of which 75% is derived from the hepatocyte, and 25% is from the cholangiocytes. Approximately half of the hepatocyte component of bile flow (about 225 ml per day) is bile salt-dependent and the remaining half bile salt independent. Bile Salts are formed in the body by combining bile acids and alcohol sulfates. Bile acid is combined with glycine or taurine to form bile salts. This is a good article explaining how to increase bile salts and the benefits of doing so. Taurine has been found to increase sulfur digesting bacteria which would increase H2S which can inhibit bile production. The is most likely why the western diet causes health problems it is high in taurine.

https://draxe.com/bile-salts/

Osmotically active solutes such as glutathione and bicarbonate promote bile salt independent bile flow. Canaliculi empty bile into ductules or cholangioles or canals of Hering. The ductules connect with interlobular bile ducts, which are accompanied by branches of the portal vein and hepatic artery forming portal triads. Bile is subsequently modified by ductular epithelial cells as it passes through the biliary tree. These cells, known as cholangiocytes, dilute and alkalinize the bile through hormone-regulated absorptive and secretory processes. The hormones are scecretin, acetycholine, ATP, and bombesin. So you can see the importance of making sure we address any issues we have that can inhibit acetylcholine production or cause ATP to become depleted. Issues with glycolysis can cause a loss of ATP. I do not know much about increasing ATP except that creatine helps increase ATP production.

The cholangiocytes have receptors which modulate the bicarbonate-rich ductular bile flow, which is regulated by hormones. These receptors include receptors for secretin which regulates water homeostasis, somatostatin decreases stomach acid production, cystic fibrosis transmembrane conductance Regulator (CFTR) not sure how to describe this one. It is kind of an ion channel/ABC transporter and chloride-bicarbonate exchanger this is where electrolytes are important. These are listed in order of importance sodium, calcium, magnesium and postassium .

For example, when secretin stimulates receptors in the cholangiocyte, a cascade is initiated which activates the CFTR chloride channel and allows the exchange of bicarbonate for chloride. In contrast, somatostatin inhibits the cAMP synthesis within the cholangiocytes causing the opposite effect. While bombesin, vasoactive intestinal polypeptide, acetylcholine, and secretin enhances bile flow, somatostatin, gastrin, insulin, and endothelin (endothelin are involved in electrolyte homeostasis) inhibit the flow. I do not have enough experience with reducing insulin levels and had to have a friend help me with that on facebook. Some metabolic disorders can cause low glucose levels and high insulin levels. It can be corrected but takes someone who is knowledgeable.

Bile Acids Cholesterol catabolism by hepatocytes results in the synthesis of the 2 major primary bile acids, cholic acid, and chenodeoxycholic acid. This process involves multiple steps, with cholesterol 7alpha-hydroxylase (CYP7A1) acting as the rate-limiting enzyme. It is effected by steroid hormones, inflammatory cytokines, insulin and growth factors.

Primary bile acids undergo dehydroxylation by bacteria in the small intestine, forming the secondary bile acids deoxycholic acid and lithocholic acid, respectively. Deoxycholic acid breaks down fats. High protein diet increases deoxycholic acid. Excess lithocholic acid speeds up aging and is carcinogenic. Eating lost of fiber reduces lithocholic acid. Artichoke reduces lithocholic acid and stimulates bile production. If the vitamin D receptor is inhibited then lithocholic acid cannot be detoxed by the body.

Both primary and secondary bile acids are conjugated by the liver with an amino acid, either glycine or taurine. Conjugated bile acids are known as bile salts. Bile salts inhibit cholesterol 7alpha-hydroxylase (CYP7A1) , decreasing the synthesis of bile acids. Despite the increased water solubility of bile salts, they are amphipathic molecules overall (has both hydrophobic and hydropholic molecules). This critical property allows them to effectively emulsify lipids and form micelles with the products of lipid digestion. The bile acid pool is maintained via mainly the enterohepatic circulation and to a small extent (about 5%) by hepatic synthesis of bile acids, as long as the daily fecal loss of bile acids do not exceed 20% of the pool. Micelles help with fat absorption.

Venous blood from the ileum goes straight into the portal vein, and hence through the sinusoids of the liver. Hepatocytes extract bile acids very efficiently from sinusoidal blood, and little escapes the healthy liver into systemic circulation. Bile acids are then transported across the hepatocytes to be resecreted into canaliculi. The net effect of this enterohepatic recirculation is that each bile salt molecule is reused about 20 times, often two or three times during a single digestive phase. When the digestive system is healthy bile gets easily reabsorbed.

Chenodeoxy cholic Acid and Cholic Acid are the primary bile acids produced. From Chenodeoxy cholic Acid many other bile acids are produced.

Bile acid gets reabsorbed and returned to the liver to be recycled. There are secondary bile acids produced in our digestive tract by our gut bacteria. Our microbiome deconjugates bile. Deoxcycholic Acid is a secondary bile acid produced by our microbiome. It is recycled by the body and is conjugated with glycine or taurine and circulated with primary bile acids. It constitutes about 20% of biles acids.

Lithocholic Acid is a secondary bile acid. It is conjugated with glycine or taurine and sulfated producing sulfolithocholylglycine or sulfolithocholyltaurine. Lithocholic Acid is toxic and can destroy the liver. Sulfation is an important part of detoxing deconjugated bile acids. Sulfation of bile acids decreases their absorption rate which prevent them from reentering the liver so when sulfation is functioning properly then the body can easily detox the toxic bile. Sulfation can become inhibited by metabolic issues, high sulfur digesting bacteria raising hydrogen sulfide and sulfide levels in the body. If there are problems with the CBS or BH4 pathways sulfation can be effected. The SULT genes are effected by our hormones. A change in our gut bacteria, toxins, glyphosate, vaccine injury, infections, leaky gut and many other things can change our hormone levels. This can inhibit the ability for the liver to sulfate bile acids. The pregnane X receptor also know as the xenobiotic sensing nuclear receptor has been found to be inhibited in those with bile blockage disorders. Inhibited PXR can inhibit SULT genes. Those with upregulated PXR have been found to be protected from the negative effects of LCA. Constitutive Androstane Receptor (CAR) is involved in sensing and removing endobiotic, and xenobiotic substances. It detoxes foreign substances and drugs. It has be found to protect form LCA when upregulated by inducing SULT genes. CAR is also involved in energy homeostasis. Fasting can induce CAR. Vitamin D receptor, Liver X receptor, and Farnesoid X receptor are also involved in sulfation and upregulation hve been found to protect from LCA. Most of those receptors have been found to be inhibited in those with bile blockage. Showing the importance of supporting their proper function.

When there is an obstruction biles acid can spill over into the blood stream through OST a and b transporters and also can enter the blood through Multidrug Resistance-associated proteins M1M3,M4 and M6. When there is an obstruction urinary excretion of bile is the primary route of bile removal. If this continues for an extended period of time it can lead to bladder irritation from the caustic effects of the bile acid to the bladder. Constipation form inhibited bile flow is common in interstitial cystitis. This can also take place through the organic acisd transporter.

This is an interesting article on bile acid blockage. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1105662

When Lithocholic Acid cannot be sulfated it remains toxic. Lithocholic Acid is highly carcinogenic and causes cancer. High Lithocholic Acid levels inhibits cortisone production this can cause many health issues including chronic fatigue.

Cellulose has been found to increase the mucus membrane which improves bile flow.

Not sure where to go with this information but took note of it. High nitrogen levels increases bile acid oxidation, high hydrogen levels inhibits bile acid oxidation.

https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13064

Medium Chain Fatty Acids stimulate bile production which decreases bacteroides and actinobacteria which has been found to be high in those with dysbiosis and inflammatory bowel disease. Low bile acid production increases levels of microbes that produce potent LPS. Tempo a product made from fermented soy has been shown to reduce bacteriodes and inhibit our microbes ability to produce bile salt hydroxolase which inhibits FXR receptor. By decreasing our microbes bile salt hydrolase bile production is restore which reduces the bacteria that inhibit bile flow. If you try this route you would want to use organic because the BT-Toxin and glyphosate found in soy products destroy the gut and alter our gut microbiome causing an increase in microbiota that have a negative impact on our health. The FXR receptor is responsible for homeostasis throughout the body. If the FXR receptor is inhibited a person will develop diabetes, dislipademia, cancer, metabolic disorders, atherosclerosis and renal diseases.

If a person has cholestasis stimulating bile will damage the liver and cause excess bile to enter the blood causing many other health problems. If a person has cholestasis they should not stimulate bile production. Elevated bile production is a sign and symptom of sepsis which indicates cholestasis.

Things that can cause cholestasis is drugs, infection, metabolic issues, gene issues, gut dysbiosis,inflammatory bowel diseases,hormone imblance, T cell imbalcance, excessive inflammation, toxins and many other things. If a person has cholestasis they will have dark colored urine and light colored stools. Pain in the abdomine, excessive itching, fatigue and nausea. In more severe cases the skin and eyes my get a yellow color.

You have to address the cause of cholestasis if it is drug induced then you may have to discontinue the use of the drug, address infection and inflammation, correct metabolic issues and gene issues. Work on reducing gall stones and oxalate stones.

Some things found to help with bile blockage. Gaur Gum, milk thistle, dandelion, vitamin K, Vit D, Calcium but we must make sure we get the right type, sunflower seed lecithen, antioxidants but do not over use homeostasis is the goal. We need some oxidative stress if we completely disable ROS we will defeat the purpose. Radishes have been shown to help with bile blockage. Cod liver oil helps with bile blockage, medium chain fatty acids help with bile blockage, curcumin helps with bile blockage but after a while it should be pulsed because it chelates iron from the body and can cause anemia. Activated charcoal helps with cholestasis but should not be taken close to meals or we will lose nutrients. Soaking in epsom salt and then getting far infrared, sunlight or halogen light gives us magnesium sulfate which helps with cholestasis. If it is caused by gall stones apple juice and apple cider vinegar has been found to reduce gall stones. Lemon juice has been found to reduce gall stones. I had to put lemon juice in water because straight lemon juice was to strong for me and made my stomach hurt. Artichoke has been found to reduce gall stones. We need a variety in our diets, eating poorly can cause bile stones. The more processed foods we eat the better our chances of getting them are. Losing weight too quickly can also cause gall stones. Low HDL levels can cause gall stones that can be caused by hormone imbalances especially high estrogen levels. Citrus fruits reduce gall stones especially the white part of the fruit. Rosemary has been shown to reduce gall stones. Pear juice has also been found to dissolve gall stones. Beet root, carrots and cucumber has been found to reduce gall stones. Drinking excess amounts of soda pop and consuming excess amount of processed sugar can cause gall stones and oxalate stones.

Excess vitamin C can cause oxalates but normal levels help dissolve oxalates. High meat consumption increases oxalates, excessive salt consumption can cause high oxalates, soda pop contains phosphoric acid which increases oxalates and causes kidney stones. Excess vitamin D intake can cause oxlates most do not recommend get more then 5000 IU of vitamin D and many say 60 IU is enough. High meat consumption can decrease citrate in the body, citrate prevents oxalates. If a person take magnesium citrate it should not be taken often because the body recycles citrate and it can build up in the body causing liver and kidney damage. If a person has metabolic issues that cause acidosis it can lead to oxalates, I post on addressing acidosis. DNA damage from oxidative stress or health issues can cause high uric acid levels which can increase oxalates. Omega 3 oils help reduce oxalates. Celery, carrots, pomegranate, watermelon, pumpkin seed oil. Helps reduce oxalates. Horsetail herb helped me a lot but has an alkaloid that can build up in the body so should not be taken more then three times a week. Citric acid not to be confused with vitamin C reduces oxalates this is why lemon is very good for reducing oxalates. Bear berry and uva ursa contain berberine which reduces oxalates and uric acid. Stinging nettles reduces oxalates and toxins that can cause oxalates. Stay hydrated but avoid water that has been chlorinated or fluorinated it is toxic an increases oxalates.

High Trymethylamines produced from our microbiome breaking down choline and carnetine is converted by Flavon Mono-Oxygenase 3 to Trymethylamine-N-Oxide. TMAO inhibits bile production. Olive oil has been found to prevent our gut microbiome from producing Trymethylamines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215539/

Crushed flax seed and oat haul increases bile flow.

If we do not correct the health issues causing our bile receptors to be inhbited it can lead to Non Alcohol Fatty Liver Disease.

https://gut.bmj.com/content/67/10/1881.long

Balancing the immune system

https://iamajuicer.wordpress.com/2018/07/15/autoimmunity-what-causes-it-and-things-that-may-correct-it/

Reducing oxalates.

https://iamajuicer.wordpress.com/2018/07/13/high-oxalates-also-know-as-oxalosis-or-hyperoxaluria/

Healing the gut is very important.

https://iamajuicer.wordpress.com/2018/12/01/things-that-can-go-wrong-in-the-gut-and-how-you-may-be-able-to-correct-them/

information on our gut microbiome.

https://iamajuicer.wordpress.com/2018/11/19/true-cause-of-illness-and-things-that-may-help/

Things that may help with infections.

https://iamajuicer.wordpress.com/2018/08/12/herbs-that-help-with-infection/

Things that can break down scare tissue in the body is autophagy which I have posted on and HSP70 which is another thing I have posted on. Serrapeptase has been shown to break down calcium deposits and aggregates in the body. It must be used with caution. High dosage can start breaking down tissue in the body but low dose will reduce inflammation and help the body heal.

https://iamajuicer.wordpress.com/2018/07/22/heat-shock-proteins-and-their-effects-our-our-health/

Inflammation and toxins is why so many are ill now days.

https://iamajuicer.wordpress.com/2018/11/19/true-cause-of-illness-and-things-that-may-help/

Things that can go wrong in the gut and how you may be able to correct them.

This is not medical advice I am posting this for educational and informational purposes.

 

Always remember homeostasis is the goal.

This is not finished but I need to work on other things and I figure this will give people a good foundation to research and build on.

Lipopolysaccharide (LPS) is usually used when referring to pathogens. Our commensal microbes produce LPS which our body uses to identify them. Normally they are not harmful to the body and some of the other commensal consume LPS keeping levels down. But a loss of those commensal or leaky gut can cause LPS to enter our blood streams which can lead to sepsis so it is very important to protect and maintain the health of our guts.

If we develop leaky gut and do not correct it toxins like mercury that can be in our food and usually will get excreted can now easily enter the blood stream and a person may develop high levels of mercury, cadmium or other toxins in the body.

If you have leaky gut oxalates that usually get excreted can enter the body. It is very important to heal the gut because oxalates are very damaging to the body. Calcium will bond with oxalates preventing them from being absorb and is why if a person is lactose intolerant they need to work on correcting it because milk with meals would help prevent that. Some calcium supplements are not good for you so if you decide to take that route make sure you do your research. Once oxalates build up in your body it prevents the gut from healing so it is very important to reduce oxalate levels. I have posted on reducing oxalates.

There are 2 components to the intestinal barrier. Intrinsic barrier and extrinsic barrier.

Intrinsic barrier is composed of the epithelial cells lining the digestive tube and tight junctions that tie them together.

Our gut bacteria maintain the health of our gut but damage to our gut can inhibit FUT2 production. Our gut microbiome cannot get established if we are deficient in FUT2. Lactobacillus Casei increases FUT2 production by inducing ERK/JNK. Inducing ERK/JNK stimulates FUT2. Nitric Oxide induces ERK/JNK, arginine rasises NO levels. Hypoxia induces ERK/JNK. Interleukin 10 inhibits FUT2 so a person may want to be cautious when taking probiotics that stimulate IL-10. Lactobacillus species of microbiotia stimulate IL-22 especially L Johnsii. IL-22 stimulates FUT2 secretion.

Extrinsic barrier consist of secretions and other other influences like microbes that influences the epithelial layer but are not physically part of the epithelium cells and maintain their barrier function.

Intrinsic Intestinal Barrier.

The gut is lined by sheets of epithelial cells that define the structure of the mucosa they are tied together by tight junctions, which paracellular spaces and thereby establishing the basic gastrointestinal barrier. Paracellular spaces are were nutrients are transported into the blood stream and toxins can be transported to the intestines for removal. Toxins and microbes that are able to breach this barrier have unimpeded access to the circulatory system. The tight junction layer and the mucus membrane for the most part prevents this from happening when healthy. Some cells in the epithelial are not effected by acid but others do not have the protection so count on the mucus membrane to protect them.

Extrinsic Barrier

Mucus that coats the entire epithelium. Hormones and cytokines that regulate the function of our digestive system and maintain digestive health. Our gut microbiome are a part of the extrinsic barrier. They reside in the mucus membrane.

Tight junctions encircle the epithelial cells and are an important part of the intrinsic layer. Their permeability is regulated by zonulin.

Tight junction controls the equilibrium between tolerance and immunity to non-self antigens. It is involved in macromolecular transport and tolerance and immune balance. If the tight junction layer becomes too porous a person may develop autoimmunity and their bodies immune system will turn on the body and start causing autoimmune disorders. A person will develop food allergies and food intolerances. The longer this goes without being addressed the more a persons health will decline. They will develop many metabolic, genetic and immune dysfunctions. Many things can damage this vaccines have been shown to raise B cell levels which causes the tight junction layer to become more porous. BT Toxins in GMOs have been shown to cause the body to react in a way that the tight junction layer becomes more porous. Many farm chemical cause it to become more porous especially glyphosate and glufonisate cause it to become more porous. Stress and trauma can also cause the tight junction layer to become more porous.

Zonulin is the only intercellular modulator of the tight junctions. If zonulin becomes over expressed the gut becomes more porous leading to leaky gut. It is involved in the transport of macromolecules and in balance between tolerance and immune response balance. If zonulin becomes deregulated it can cause inflammatory bowel, anemia, systematic inflammation, red sore areas on the skin known as Sweet’s syndrome that can eventually develop into blisters that eventually turn ulcerative which is known as Pyoderma Gangrenosum. They can develop swelling and sores in the mouth. The eyes can become red sore and inflamed. This condition is called sceritis it can lead to uveitis which effects the iris and can lead to blindness. Bones may thin and become brittle. Oxalates will develop causing stone formation this can also effect the liver. Not only can it cause endogenous oxalates to be produced but now oxalates consumed in our foods that are normally excreted can readily enter the body. Gall stones may form because bile production and pancreatic enzymes become inhibited and a person can develop chronic diarrhea, constipation or alternate between the two.

When the bile is inhibited it is called Primary Schlerosing Cholangitis. From food particles and toxins entering the blood stream a person could start having excessive blood clotting. A person will start developing nutrient deficiencies from being unable to absorb and break down nutrients properly. A person will eventually develop high histamines if this continues they may develop asthma, they can start developing sarcoidosis throughout the body. Mast Cells can start to degranulate leading to mastocytosis or mast cell activation syndrome. This effects our immune system as you will see below. It can lead to diabetes, heart disease and many other chronic illnesses. It can also lead to obesity or anorexia depending on how the person has been effected.

In order to restore zonulin levels to normal the genetic, metabolic, oxidative stress, changes in ph for example if you have developed acidosis or alkalosis it will have to be addressed along with infections that come along with our immune system being disabled. I have posted on most of those issues and correcting them. There are three isoforms of zonulin. ZO- 1 , ZO-2 and ZO-3.

When we get an infection it is a sign we are lacking a nutrient or gut microbe that protects us. The infection produces lipopolysaccharide (LPS) which stimulates zonulin making our guts more porous. Also antibiotics can kill the butyrate producing gut bacteria which makes our gut more porous. Butyrate keeps many things at homeostasis. We cannot restore normal zonulin levels if we do not replace the butyrate producing bacteria and feed them with fiber, oligosaccharides, galactosaccharides, and fructooligosaccharides. The lower the diversity of our gut microbes the higher our zonulin levels will be showing that our digestive system needs feedback from a variety of microbes to function properly.

The fun part of all of this is they will tell you all this in in your head until you are so ill it will take months or years to heal. In the mean time they will still continue to treat the symptoms instead of the cause. It is a common theme with allopathic medicine. I have seen this with naturopathic also but for the most part naturopaths treat the cause and not the symptoms.

Things that can reduce zonulin is meditating, if you have experienced trauma work very heard to move forward. It is difficult not to look back but constantly looking back causes stress and can increase zonulin. Anger increases zonulin so try to learn to deal with frustration and bad situations in a calm way , the calmer we are the lower our zonulin levels will be.

Replace the butyric acid producing bacteria I listed many microbes that produce it if you search my blog.

Inflammation and immune dis-regulation and can increase zonulin so the microbes that increase T regulatory cells and inflammation will reduce zonulin. If your immune system has been disabled then microbiome that stimulates IL-10 will help restore immune function.

High LPS levels will increase zonulin so we need the gut microbes that reduce LPS. Studies have shown the higher our guts diversity the less ZO-1 is express which prevents leaky gut and inflammation.

Under normal conditions things with gliadin , glutin and lactose will not effect a healthy gut but increase zonulin when the mucus membrane is damaged.

There are many molecules that interact with each other to maintain the Zonulin layer and the tight junction layer.

Occludin plays a role in tight junction maintainence and assembly which is regulated by phosporylation of serine, threonine, and tyrosine risidues. It is important for maintaining TJ stability and function. Loss of occludin can lead to leaky gut, inflammatory bowel, and hyperplasia most likely from the inflammation. Occludin also regulates cell survival or death through the intrinsic system. It is important in receiving and transmitting cell survival signals. Occludin has a strong inhibitory effect on cancer. Loss of Occludin leads to cell death.

If Phosphorylation of tyrosine, threonine and serine residues is inhibited it reduces occludins interaction with zonulin. Dephosphorylation of ser/thr residues and poor phosphorylation of tyr residues causes a reduction in occludins interaction with ZO-1 leading to it’s seperation from the junctional complex and TJ disruption. It also leads to excess ROS production which increases gut permeability. Inflammation reduces occludin levels. Endotoxins also reduce occludin. Another function of occludin is in modulating the TJ response to cytokines to protect and heal the tight junction. Occludin plays an active role in cellular location of caveolin-1. Caveolin-1 is required for cytokine induced TJ barrier changes, where it is required for TJ remodeling. So addressing endotoxins, high B cell or T cell levels and reducing inflammation is very important for preserving occludin. Many of our commensals that increase T regulatory cells balance our immune system which would restore proper T and B cell levels. Many of our commensal microbes reduce inflammation and reduce LPS (endotoxins). I have posted on my blog which of those accomplish these things. TNF-a is involved in caveiolinn-1 mediated internalization of occludin which increases occludin, alleviating cytokine induced gut permeability. This can be induced by TNF-a which is an inflammatory cytokine.

Mucous Membrane

The mucus membrane is thin in most inflammatory bowel diseases but is thick in Chron’s disease which I have not researched much on. Inflammtion usually causes the globin which are the mucin secreting cells to become depleted but for some reason this does not happen in Chron’s disease.

All these genes listed below are negatively effected by leaky gut. It is very important to reduce inflammation and work on getting the gut healed to restore the mucous membrane. Damage to the digestive system and mucus membrane causes many genes to become dis-regulated. MUC2 gene is the major gene responsible for the secretion of gel-forming mucin in the intestinal tract. It coats the endothelial surface protecting it from inflammation,chemicals, damage and infection. There are 20 MUC genes. There are many mucin categories that are enriched with proline, serine, and threonine. They are modified by o-glycosylation that creates oligosaccharides that confer on mucins their individual functions. Mucin is made mostly of fat. Those with inflammatory bowel and ulcerative colitis have low B-oxidation which is needed for the break down and use of fats. Since the mucous membrane is mostly fat this causes it to become dysfunctional. This makes people sensitive to fats and is why it is best if they consume medium chain fatty acids because the body can readily use them. Eggs yolks are a good source of phosphatidylcholine which is what the mucus membrane is mostly made of. Most with inflammatory bowel or colitis are sensitive to lecithin. I used sun flower seed lecithin and I did not react to it and it helped me a lot with my healing. Most other sources of lecithin I had to avoid. There are many studies showing that using sun flower seed as a source of lecithin has been shown to heal the gut. As for Chron’s disease I have a theory I have not had a chance to research but I believe they may be deficient in commensal microbes that digest sialic acid. Many of our commensals need it to thrive. Bacteroides Fragilis, Bacteroides Thetaiotaomicron, Bifidobacterium Bifido, Bifidobacterium Longhum, Bifidobacterium Infantis, Akkermansia Muciniphila all need sialic acid to thrive. Another theory I have about Chron’s that I have not gotten to research is they may have an overgrowth of those and that inflammation or LPS is stimulating the production of excessive sialic acid causing and overgrowth of those microbes.

Phospholipase A2 activity is higher in those with inflammatory bowel and colitis.

If a person is having trouble with methyl donors they will not produce enough phosphatidylcholine because methyl groups are used in the process of producing phosphatidylcholine for the mucous membrane. So combine that with the low B-oxidation and you see why it can be so difficult to heal. Disulfide bridges are also a component of phosphatidylcholine showing the importance of addressing things that can impair sulfation.

Phospholipase A2 is high in those with inflammatory bowel and colitis. Phospholipase is stimulated by inflammation. It is a mixture between inflammation and substance P and is why those with leaky gut have high substance P levels. When substance P levels get high the skin will have a burning sensation especially in the scalp and it may go down the spine. Substance P levels increase at night so the symptoms will worsen at night.

Annexin also known as lipocortin keeps PLA2 in check. Adrenal hormones increase Annexin but in many people with inflammatory bowel the adrenals become depleted from being over activated and they develop Addison’s disease which is a deficiency of adrenal hormones. Adaptogens help alleviate this which would help restore annexin levels. Annexin also helps repair our immune system. If annexin gets low the blood brain barrier becomes porous because it helps maintain the blood brain barrier. Annexin is also involved in protecting the brain from infection. It is very important to support the adrenals with the proper nutrients and to reduce inflammation so the adrenals can recover. Oddly Okadaic Acid a toxin found in shell fish increases annexin. This is something a person would definitely need an experienced medical professional to do. IL-6 increases annexin expression. To restore normal cortisol levels stress management is very important. Increased stress depletes cortisol. Getting rest is important, even if you cannot sleep just laying and resting can help increase cortisol. Avoid, caffeine, alcohol and smoking. Our mucosal layer will take up fats and integrate them to strengthen itself. Omega 3 oils, cod liver oil, nuts, and avocados help increase cortisol. Avoid processed sugar it depletes cortisol levels. Citrus fruits especially grape fruit increases cortisol but grape fruit inhibits certain cytochrome P450 enzymes so should not be eaten too often. Eat foods high in melatonin or take melatonin supplements at night which will increase cortisol. Non processed carbohydrates help increase melatonin. Magnesium is important for maintaining proper cortisol levels. Reducing inflammation can help normalize cortisol levels. Earth grounding and getting sunlight help to normalize cortisol levels. I still laugh when I mention earth grounding because I thought how could something so simple have so many health benefits. So I was determined to find research to show those earth grounders were crazy instead it was I who was crazy and the earth grounders are correct. I could find no research to prove them wrong but plenty of research showing the many health benefits of earth grounding.

We have to keep in mind goblet cells build our mucus membrane and when inhibited by inflammation, toxins or even damage to our digestive system our ability to produce mucin is reduced or inhibited. Bismuth even though it is a metal, is for the most part none toxic it takes very high doses for a very long time to reach toxic levels. It helps the gut heal. It kills many pathogens and can cause commensals that have turned pathogenic to go back to commensal. Mucilage helps protect the gut so it can heal. I have posted on reducing inflammation if you search my blog. Oatmeal is high in mucilage but you must get organic because they use glyphosate and glufonisate on grains and beans to dry them and those destroy our gut and kill our gut microbes. Three very good sources of mucilage is okra, arrow root and oatmeal. Make sure the oatmeal is organic. Most non organic oatmeal has farm chemicals that destroy the gut.

Here is an in depth article on mucus membranes.

https://www.readkong.com/page/the-interaction-of-the-gut-microbiota-with-the-mucus-1350713?p=1

Sialylation has been found to be increased in those with inflammatory bowel dieseases. Excessive sialylation increases inflammation. IL-10 inhibits Sialylation. Their are probiotics that increase IL-10 but IL-10 inhibits FUT2. So an oligosaccharide,galactosaccharride and fructosaccharide would probably have to be supplemented with it. I suspect the body is trying to increase the commensals that rely on the nutrients produced by sialylation and they have been depleted by antibiotics. Some commensals rely on FUT2 but others rely on sialylatin. Some do not produce the enzymes to break down sialic acid and rely on other commensals to produce it. A deficiency in either of them is probably what is causing the high sialylation. The body is trying to feed them. It is not getting the feedback from those commensals.

The bacteria this would help thrive are B Fragilis, B Theaiotaomicron, B Bifidum, B Longhum, B Infantis and A Muciniphila. I believe those with inflammatory bowel especially those with Chron’s will be deficient in those because those with Chron’s have a thicker mucous membrane.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747158/

The increased inflammation and infection caused by the above mentioned things results in an accumulation of ROS which can lead to further damage and it disturbs mitochondria function and autophagy. Once the mucus membrane has been damaged all the things mentioned below lose their protection and become dysfunctional. It may be necessary to take mucilage and bismuth to help protect them and restore their function. Once the mucus membrane breaks down it creates a cycle that has to be broken because the mucus membrane needs the things mentioned below to function properly and they need the mucus membrane to protect them and to function properly. Dysfunction in either of them from infection or toxins can start a cycle that has to be broken to heal. Our gut microbiome cannot become established without the mucus membrane because it also protects them. Our mucus membrane is a mediator between host and microbiota interactions. Decreased mucus membrane thickness causes a change in our gut microbiome and makes us more prone to infections.

This is where addressing sulfation issues, methyl group issues and issues with thiols comes in because the production of mucin requires all of those to be functioning. I have posted previously on how to deal with those issues. For the production of the oligosaccharides the endoplasmic reticulum and stem cell are required.

L-cysteine, L-arganine, L-threonine, L-serine, and L-cysteine increase mucin production in the digestive system and have been shown to promote gut microbiome homeostasis. Citrus fiber increases mucin especially the white part of the fruit. Pectin stimulates Goblet cell formation which secretes mucin. The microbiome that help restore gut health are Bifidobacterium Bifido, Bifidobacterium Breve, Bifidobacterium Lactis, Enterococcus Faecium, Lactobacillus Acidophilus, Lactococcus Lactis

For those who do not have glutamate issues bone broth heals the gut very quickly. Those who have high levels of sulfur digesting bacteria will have problems with the consumption of bone broth also.

The small intestine is the portal for the absorption of most nutrients in the body. The chyme which is the digested food that has exited the stomach enters the small intestine pancreatic enzymes and bile is secreted. This breaks the food down and if functioning properly it will be almost liquid when it enters the lower intestinal tract. Bicarbonate is also added by the body to reduce the acidity before it enters the large intestine. The enteric nervous system and gastrointestinal hormones regulate this process and the intestinal motility. Intestinal dysbiosis can cause incorrect communication or inhibited communication which leads to inflammation, intestinal damage and it could lead to a loss of the ability to produce bile and digestive enzymes. To restore proper function we must reduce the microbe causing the problem. Those who have high sulfur digesting bacteria will develop high hydrogen sulfide levels which interferes with sulfation and can interfere with the proper function of the CBS and BH4 pathways. This can lead to high sulfide levels in the body. BH4 levels will become low causing ammonia to build up when protein is consumed. The high ammonia levels will cause some commensals to go into protection mode and they will become pathogenic. Candida and H Pylori are two examples. To make matters worse they also start producing ammonia to protect themselves from the acidic environment. The digestive tract is supposed to be acidic. Ammonia alkalizes it this also makes us more prone to infections because the commensal microbes that protect us cannot survive in an alkaline environment. When we lose our commensal bacteria we lose proper immune function and our zonulin levels increase and our gut becomes more porous leaving things enter the blood stream that could not normally enter. Inflammation and oxalates can inhibit bile flow causing it to back up, when this happens the gallbladder is effected. Instead of addressing the problem modern medicine gets rid of the symptom by removing the gallbladder thus the illness continues to worsen and taking the gallbadder out can contribute to it’s progression.

If bile becomes inhibited it inhibits the vitamin D receptor further inhibiting bile production and adding to the problem because cholesterol production and conversion becomes inhibited. This will make bile become sludgy leading to low bile flow which will increase estrogen levels and cause high unbound copper levels in the blood. Bitter herbs increase bile flow but the vitamin D receptor has to be addressed along with balancing the microbiome in the gut and healing the intestinal tract.

This is why I often times recommend grape seed extract and bacopa to people. It prevents thrombosis. Inflammation because endotoxins can cause thrombosis. Grape seed extract and bacopa reduce inflammation and prevent thrombosis. If thrombosis occurs in the portal vein it will effect the liver, pancrease, and digestive system. This causes pain in the stomach, bloating, inflammation, pancreatic pain, pain in the gallbladder. This can lead to death. Bile flow will become inhibited speeding up the progression of portal vein thrombosis. Those with hepatitis need to use hawthorne or something else. Resveratrol activates hepatitis.

portal vein thrombosis

gastrointestinal symptoms (ex: abdominal pain, nausea, vomiting, and diarrhea), fever and constitutional symptoms (ex: fatigue, malaise, and anorexia/weight loss) [3]. We can also find hepatomegaly with elevated liver enzymes and jaundice [3], when associated with liver abscess or cholangitis [2]. Laboratory tests usually demonstrate elevated markers of inflammation [2]

https://www.journalmc.org/index.php/JMC/article/view/3050/2378

If not addressed in time it can lead to portal hypertension. This results in brain swelling, abdominal swelling . Confusion, anemia and low white blood cell count.

https://my.clevelandclinic.org/health/diseases/4912-portal-hypertension

Autophagy is very important in maintaining health and we need a proper balance. It can be disrupted if we have intestinal damage. If autophagy is inhibited we become prone to infection and mitochondrial dysfunction. Autophagy is the housekeeper of our cells. One common theme you will see is inflammation and shows the importance of reducing inflammation. Which could involve diet changes, addressing metabolic issues, reducing toxins and infections. Addressing detox issues and detoxing in an appropriate manor for the individual. Addressing gene issues which could be caused by any number of things including a lack of the microbe in the gut that may modulate that genes function.

The mucus membrane in our digestive system protects us from infection, physical and chemical harm. Our commensal bacteria cannot exist without it. It is very important to restore our mucus membrane when damaged in order to restore intestinal homeostasis. Many genes mentioned below are effected when it is damaged because it causes a dysfunction in them. Autophagy is very important for the maintenance or proper gene function.

Paneth cells are located within our mucus membranes and provide immunity, prevent damage to the digestive system and is involved with nutrient absorption. Loss of our mucus membrane from loss of microbiotia, drugs or farm chemicals found in our food can destroy our mucus membrane. This causes damage to the digestive system which can further inhibit the bodies ability to produce mucin. This makes us more susceptible to infection. Paneth cells stimulate the production of AMPs which fight infection and modulate commensal microbiome and innate immunity. A list of AMPs are defensin-like human lyzosome, defensin (HD)-5 and 6, lyzosome, regenerating islet derived gamma(Reg3y), and phospholipase A2 group 2A(sPLA2) as well as inflammatory cytokines such as Transforming Tumor Necrosis Factor A (TNF-a), Growth Factor B1 (TGF-B1), and Postaglandin E2. AMPs are sensitive to ER stress which I discuss below.

Autophagy protects against infection by producing Antimicrobial Peptides and degrading organelles that break down misfolded proteins and AMPs break down pathogens. This can ease the over activated inflammatory response and over active immune response. Some AMPs are defensin and cathelicidens which protect against microbes.

Intestinal Epithelial Cells. (IECs) – form a physical and chemical barrier involved in inflammatory response and immune reaction. IECs work as an interface between the quantitive microbial ecosystem in the intestinal lumen. Lumen is inside space or opening in a tubular structure.

There are 6 types of IECs

Goblet Cells which secrete mucin to build up the mucin barrier.

Enteroendocrine cells which produce gastrointestinal hormones that communicate with the nervous system, the brain and organs throughout the body. They respond to nutrients within the intestines. Helps restore intestinal tissue.

Absorptive Enterocytes – epithelial cells in small intestine. They are involved in nutrient absorption, absorption of conjugated bile acid, lipid uptake, Issues with Absorptive Enerocytes can inhibit glucose absorption and can result in lactose intolerance and many other food intolerances. It can also result in an electrolyte imbalance. Enterocytes secrete a series of chemokines and cytokines which regulate immune responses of subjugant mucosal. (Mucosal control)

Tuft Cells – brush cells which are chemosensory cells in the intestinal epithelial lining. Tuft refers to microvilli projecting from the cells. They increase during parasite infection. They are the sole source of Interleuken 25 which induces NF-kB activation which helps protect from infection. High levels of IL-25 raises eosinophils which causes inflammation and is suspected of causing inflammatory bowel diseases. Eosinophils have been shown to kill many types of cancer cells. Infection also stimulates Tuft Cell to produce IL-25. They are increased through a T cell response through a type of lymphatic tissue. Tuft cell also secret endogenous opioids. Eosinophils cause asthma, cardiovascular disease and can even cause headaches, mood swings and brain fog.

Microfold Villous Cells – are found in the Gut-associated Lymphoid Tissue (GALT) of the Peyers Patches in the small intestine and the Mucus-associated Lymphoid Tissue (MALT). M Cells initiates mucosal immunity. They allow the transport of microbes and across the epithelial cell layer. From the gut lumen to the lamina propria. M cells contain Epidermal growth factor which acts as a sensor to stimulate repair through the intestines including the mucus membrane , tight junction protein layer and it stimulates goblet cell differentiation and many other things in the colon.

Endoplasmic Reticulum are organelles within our cells and plays a major role in the production of proteins and lipids. So this is where our enzymes , hormones and even our detox enzymes are produced.

Endoplasmic Reticulum Stress Unfolded Protein Response (UPR) is activated in response to unfolded or misfolded proteins in the endoplasmic reticulum. It stops the production of unfolded or misfolded proteins it is the quality control mechanism. It will stop production and start cleaning the bad proteins out. If it continues for too long then it will induce apoptosis which is cell death. If overactivated which vaccines and many farm chemicals can cause to happen it can lead to prion disease. It plays a valuable role in intestinal endoplasmic reticulum survival and function. Dysfunction of endoplasmic reticulum can result from genes that have been effected from infection, toxins, or even stress can result in abnormal UPR function. This is referred to as Endoplasmic reticulum stress.

ER stress activates three kinds of proteins which reside in the ER membrane to detect UPR in ER Lumen and resolve them. Autophagy reduces ER stress.

inositol-rquiring membrane kinase endonuclease1 (IRE1) via a really long pathway that I am certain you do not want me to type out. Issues with the genes involved in these mediators in intestinal endothelial cells will change the histological structure of the intestinal epithelium.

XBP1- inhibition will exhibit impaired Paneth Cells, which leads to dysbiosis and spontaneous intestinal inflammation which may induce activation of NF-kB pathway which can lead to inflammation, anxiety, chronic depression, insulin and leptin resistance, it increases risk of cardiovascular disease and high TH17 levels which can lead to psoriasis or lupus, Many who have intersitial cystitis have high TH17 levels. It can cause bone lose and Alzheimers. On the other end of the scale not enough NF-kB can produce many health problems. Like lower cognitive function, inhibited ability to heal, inhibited nerve growth and brain plasticity. This is a good article covering it in more detail. https://www.selfhacked.com/blog/nuclear-factor-kappa-b/

The second gene that can increase risk of inflammatory bowel disease is oromucoid-like3 (ORMDL3). Over expression can lead to immune/inflammatory diseases. It has been linked to childhood asthma. Over expression causes inhibited calcium buffering capacity of the mitochondria. This can disrupt endocytosis, enzyme control , cell growth and proliferation and cell apoptosis. ORMDL3 takes part in protein folding and in regulating UPR. It is believed ERs induced inflammation in paneth cells may disturb ORMDL3 levels leading to inflammation.

TREM1 (Triggering Receptor Expressed On Myeloid Cells-1) inhibits autophagy and increases ERs stress levels. This has been shown to increase the severity of inflammatory bowel diseases. Defective autophagy in the endoplasmic reticulum can predispose someone to inflammatory bowel diseases form a decreased clearance of IRE1 during ERs. High IRE1 levels impairs insulin signaling this can lead to many metabolic diseases. TREM1 can either increase inflammation or decrease it. During infection TREM1 increases inflammation. TREM1 also interacts with other inflammatory pathways which can also result in TREM1 increasing inflammation. TREM1 is high during septic shock. Sustained increased levels of TREM1 can lead to inflammatory bowel disease, cardiovascular disease and atherosclerosis. TREM1 is needed to help clear infection. Unfortunately when an infection that contains OspA protein that are difficult for the body to clear like HIV and Borellia (Lyme Disease) it can cause TREM1 levels to remain high. This is why it is very important to work on reducing inflammation and address infection. Most infectious diseases there are no test for and the test they do have has a high failure rate at detecting the microbe responsible for the illness. But the body and what genes are effected and cytokines present can indicate when there is an infectious agent present. The more difficult infections can be killed but it takes a multilevel approach because most that carry the OspA take multiple forms and have to be addressed differently for each form it has taken.

Inflammatory bowel disease have been shown to have a dis-regulation of T Cell which can be induced by toxins, drugs, vaccine injury, farm chemical or processed foods.

Autophagy is a conserved lysosome-dependent catabolic process involved in degrading and recycling aggregates as well as damaged organelles. Enhancement of autophagy promotes the survival of various cells including intestinal endothelial cells, and nuetrophils by protecting them from microbial toxins. A disturbance in autophagy could disturb the function of intestinal endothelial cells and influence inflammatory response, immune response, ROS levels and endoplasmic reticulum stress. This can lead to inflammatory bowel diseases. Autophagy plays a vital role in alleviating of intestinal inflammtion, degredation of damage associated molecular patterns (DAMPS), which can help prevent inflammatory bowel diseases. PAMPs refer to various kinds of endogenous materials produced by stress, impaired or dying cells covering DNA, RNA, ATP, histones, hyaluronan, uric acid, heparin sulfate, the S100A calgranulins, IL-1, HSP, and chromatin-associated high motility box1(HMGB1).

Basal autopaghy occurs in nearly every cell to maintain homeostasis of the ammino acid pools. There are three types of autophagy.

Macropahy – targets material such as cytoplasmic components or invasive bactria which are surrounded by a double-membrane bound autophagosome.

Autophagosome when combined with lysosomechanges into a single-layer membrane autolysome with a strong degradative and digestive ability.

Microautophagy – during the process of microautophagy lysosomal/vacuolar membranes invaginate (fold in on itself) to engulf intracellular components via a non-selective degradative mechanism.

Chaperone-mediated autophagy transports organelles and proteins into lysosomes only with the assistance of chaperones which are located in lysosomal lumen. Chaperons are proteins that assist in convalent folding or unfolding and the assembly or disassembly of other macromolecular structures. They assist in the assembly of nucleosomes which are basic units of DNA.

Two steps of Autophagy.

The first step of autophagy cup-shaped double membrane phagophores are shaped in the cytoplasma of the cell, and then misfolded proteins, damaged organelles or bacteria are engulfed to become sperical double membraned autophagosomes. Autophagosomes are usually considered to be produced from the nucleation and membrane expansion of phagophores.

During the second step autophgosomes fuse with lysosomes and endosomes to form a single-lipid layer autolysome, which is regard as basal units for degradation and digestion. Autophagy process is induced by the detection of various specific cues such as starvation or invasion by pathogens.

Two proteins are known to participate in autophagy which include Mammaian Target of Rapamycin (mTOR) as an inhibitor and adenosine monophosphate activated protein kinase as an indicator. mTOR is often activated by lower levels of Adenosine Triphosphate (ATP) caused by nutrient sufficiency or several growth factor stimulations. mTORC1 inhibits autophagy in the presence of nutrients. mTORC1 regulates glycolysis, lipid biosynthesis, and the pentose phosphate pathway has been found to be under the control of mTORC1. mTORC1 mediates upregulation of SREBP-1 activity which is necessary for lipid biogenesis. mTORC1 increases mitochondrial DNA copy number and as well as encoding many genes involved in oxidative metablolism. It has been found that mTORC1 promotes transcriptional activity of PPARy coactivator (PCG-1a) which is usually low in those who have inflammatory bowel diseases. This leads to the inability to break down fats and cholesterol causing many health problems because lipids are needed by almost all cells of the body especially the digestive system to maintain proper function and health. Ironically mTORC1 inhibition leads to longer lifespan. mTORC1 inhibits autophagy. mTORC1 increases NRF2 activity the master regulator of the antioxidant system.

Excess mTORC1 activation can cause endoplasmic reticulum stress and excess ROS production.

Low ATP levels inhibits mTORC1. Inhibiting mTORC1 increases glucose uptake. Hypoxia (oxygen deprivation) inhibit mTORC1. Amino Acid deprivation can inhibit the citric acid cycle (TCA cycle) this also inhibits mTORC1. The body inhibits mTORC1 when it senses DNA damage. Autophagy reactivates mTORC1 whose activity then promotes the replacement of lysosomes consumed during autophagy.

Symptoms of excess mTORC1 . Since there is no information on what excess mTORC1 does I will have list the symptoms of inhibited autophagy and high ROS levels since those are issues caused by high mTORC1 levels.

Symptoms of inhibited autophagy. Nuerological problem , inhibited autophagy can lead to inflammation in the brain, mental illness. Mitochondrial dysfunction, decreased antioxidant function which can lead to high levels of ROS. Pancreatic inflammation. Fat accumulation throughout the body and can lead to fatty liver disease. Issues with lysosomal storage, diabetes and sickle cell anemia. Frequent illness from infectious agents.

Symptoms of high ROS. ROS is needed for redox signaling but becomes damaging if levels get too high. High levels of ROS cause inflammation. Leaky gut and can cause a leaky blood brain barrier. This also can lead to nuerological damage and brain inflammation causing mental illness. Can cause liver damage resulting in a hepatic liver. Fatigue from reduced energy levels. Mitochondrial dysfunction which can lead to MS. Here is a link to a good article on oxidative stress.

https://www.selfhacked.com/blog/oxidative-stress-101/

Things that stimulate mTORC1. Resistance training, amino acid L-Luecine, Beta Hydroxy Beta-methylbutyric acid which is a precursor of butyric acid. High intake of Iron stimulates mTORC1.

Inhibitors of mTORC1 are green tea, resveratrol, curcumin, caffeine and alcohol. Iron deficiency inhibits mTORC1. Green tea can damage the liver if taken for too long and curcumin chelates iron so can make a person anemic if consumed too long.

VDR

Vitamin D receptor (VDR) mediates the activities of vitamin D3 which is the activated form of vitamin D. A deficiency can effect our digestive system in many ways. The VDR is involved in regulating 33% of the genes in the body so problems with it can effect many things. VDR and Retinoid X receptor interact to with each other and can activate each other so issues with either one can effect vitamin D homeostasis. Inhibited VDR effects calcium homeostasis, electrolyte balance, and blood pressure.

Vitamin D3 acts as a hormone a hormone and helps regulate innate and adaptive immune responses. Those with low vitamin D levels or inhibited VDR receptor are prone to infection with Mycoplasma Tuberculosis. VDR is involved in producing the antimicrobial peptide/IL-37, defensin beta B, CLDN2 encoding claudin 2 and ATG16L1 related autophagy which protects us from inefection.

The VDR receptor is involved in gut microbiome balance and autophagy. Autophagy is the house keeper of our cells it helps clean them out, protect them from infection and helps to prevent misfolded proteins. Inhibited vitamin D receptor can cause inhibited bile flow and a decrease in LDL and increase in HDL. The reduced LDL causes bile to become sludgy which leads to biliary issues and gallbladder problems and can result in gall stones and biliary blockage.

When the VDR receptor is inhibited or there is a vitamin D deficiency we can develop inflammatory bowel diseases. IKBa is an inhibitor of pro-inflammatory NF-kB.

VDR inhibition or vitamin D deficiency alters the composition of intestinal microbiome. Butyrate producing bacteria become less numerous. Butyrate increases expression of VDR so a deficiency in Butyrate would further add to the inhibition of the VDR receptor. Butyrate also suppresses intestinal inflammation and enhances AMPs. AMPs help protect us from infection.

Toxins, mold toxins, infection and a lack of nutrients can inhibit the vitamin D receptor. High levels of vitamin D3 indicates the body has recognized an infection and is trying to fight it.

Farm chemicals especially glyphosate and glufonisate inhibit the vitamin D receptor. Many toxins found in processed food can also inhibit the vitamin D receptor.

Symptoms of inhibited VDR.

If the VDR is inhibited a person may experience problems with methyl donors and low dopamine levels. They may experience frequent infections and be low in GcMAF. Inhibited VDR can cause bone loss, hair loss, brain fog, increased TH17 levels resulting in lupus, psoriasis and/or skin rashes, tooth decay and poor oral health, inflammation throughout the body, can lead to high blood pressure. Low LDL which inhibits bile production resulting in biliary and gall bladder problems and can lead to stone formation. Electrolyte imbalance and iron deficiency. Low dopamine and GABA levels is a result of VDR inhibition. Prolactin level become low when VDR is inhibited. Gut dysbiosis and inflammation in the digestive system. Increased creatine and albumin levels and decreased alkaline phosphatase are symptoms of low vitamin D or inhibited vitamin D receptor. VDR inhibition or vitamin D deficiency can result in mast sell activation syndrome. CYP3a4 an enzyme needed for detoxing xenobiotics and drugs becomes inhibited. Hormonal imbalance is also a result of VDR inhibition. Hashimoto’s syndrome can result from VDR inhibition. Heart disease can be a result of VDR receptor inhibition or vitamin D deficiency. In more severe cases VDR inhibition can lead to liver and kidney disease.

Symptoms of Vitamin D deficiency.

Joint stiffness or pain, back aches, tooth decay, bleeding gums or gum disease, muscle cramps, hair loss, bone loss, weakening of bones, increases risk for cancer, sleep apnea, brain fog, fatigue, depression, leaky gut, excess sweating especially in the head area.

Excess vitamin D can lead to many health problems and can result in loss of bone from a disruption in the mechanisms that control calcium homeostasis. Though it is needed for calcium absorption high doses can have the opposite effects. High levels of vitamin D can lead to oxalate formation. Many studies show anything over 5000 IU a day can lead to oxalate formation and many health problems.The recommended daily allowance of vitamin D is 600 IU. It is best to get vitamin D from food sources. Exposure to sunlight, far infrared, halogen lights can increase the bodies production of vitamin D. Short term raised levels have been found to be beneficial but long term raised vitamin D levels have been found to be harmful to our health. High levels of vitamin D can contribute to the inhibition of the VDR. Excess vitamin D can result in high levels of calcium in the blood resulting in calcium deposits forming in the organs including the lungs.

Sources of vitamin D. Sunlight, halogen lights, far infrared light increases the bodies production of vitamin D. Excess sunlight has been shown to cause high levels of vitamin D and is why life guards have some of the highest rates of kidney stones. Fish oil contains vitamin D. Sardine , salmon and cod liver oil are good sources. I try to make sure the fish is not from contaminated areas. Most sea food is high in vitamin D. Mushrooms and eggs are a good source of vitamin D. Animal liver is another good source of vitamin D. Cestrum Diurnum, Waxy leaf nightshade (solanum glaucophyllum), yellow oat grass (trisetum flavescens) are plant sources of vitamin D. Those plants are so high in vitamin C that they cause calcinosis in grazing animals. Brown and read seaweed are also sources of vitamin D and cholesterol. Mercury found in fish is for the most part only a problem if we have leaky gut. When the gut is intact only about 5% of the toxins like mercury get absorbed that have been consumed and when healthy the body can easily detox that amount unless it is shot directly into the blood stream. I mention this because even though they claim vaccines do not contain mercury some still do.

Things needed for the body to be able to use vitamin D. Vitamin K2, Vitamin A, zinc, sulfur is needed to sulfate vitamin D so sulfation issues need to be addressed. Magnesium increases the bodies response to vitamin D. Boron increases vitamin D in the blood stream. Water is needed, dehydration inhibits many receptors in the body. Silica helps improve the function of many receptors in the body. Sunlight helps to sulfate nutrients. DAO and lysine are also needed to sulfate vitamin D. Boron is touchy, low levels reduce estrogen high levels increases estrogen.

Things that enhance vitamin D receptor activity. Parathyroid hormone, Sirt 1, Dopamine, Omega 3 , Omega 6, Phytoestrogens, Testosterone, Postaglandulins and bile activates VDR. Bitter herbs stimulate bile production. Even if you do not swallow bitter herbs just tasting them stimulates bile production. Resveratrol activates the vitamin D receptor. Querciten enhances vitamin D receptor activity. Curcumin stimulates the vitamin D receptor but if taken for too long it can lead to anemia because it chelates iron from the body. So one may use it at first to help stimulate the VDR receptor but probably should just take maintenance doses to make sure it continues to function. Human Growth Hormone stimulates the vitamin D receptor. Sleep, fasting, and strength training increase HGH.

Things that can inhibit VDR are cortisol/glucocorticoids, high prolactin levels, imbalance in thyroid hormones, TGF-Beta, phosphatonins which regulate phosphate homeostasis, and ubiquitin can inhibit VDR. Many of these things are inhbited by autophagy which would prevent them from inhibiting the VDR receptor. Caffeine can also inhibit the VDR. High TGF-B levels can be an indication of T cell imbalance and/or B cell imblance. Probiotics that reduce inflammatin and increase T regulatory cells should reduce TGF-B. High phosphatonins is a sign of low klotho levels. Exercise increases klotho, Most Acidophilus bacteria and Lactobacillus Lactis increases klotho. Cordyceps mushrooms increase kltoho. PPAR Gamma activators stimulate klothos, Some PPAR gamma activators are berberine, magnolia, and Omega 3s. Those who are obese should not stimulate PPAR gamma because they are usually PPAR gamma dominant. Adaptogenic herbs like suma root and maca root can help normalize adrenal levels. Ubiquitin levels are reduced by autophagy. High prolactin levels can result from toxins in plastic containers used to store food and some farm chemicals found in our food supply. There are also chemicals in processed foods that can cause high prolactin levels. Those who are taking drugs should not use berberine or things that contain it because it inhibits the cytochrome P450 enzymes needed to detox medications.

Fulvic acid and nobiline induce autophagy. We do not want to overstimulate autophagy. Fasting also stimulates autophagy but those who are Type1 diabetics have to be careful fasting can induce ketoacidosis in them. Branch Chain fatty acids can inhibit autophagy. Tumeric, ginger, berberine, gensing, mushrooms and elderberries can stimulate autophagy.

NOD2 – Nucleotidebinding Oligomerization Domaincontaining Protein 2 whew that was a lot. A member of the NLP family which is a group of immune regulating proteins. It is a sensor of muramyl dipeptide which is a constituent of both gram negative and gram positive bacteria. It is found in macropages and paneth cells. When inhibited a-defensin numbers are decreased, lower sensitivity to bacteria infection, and altered immune function from Toll Like Receptors becoming suppressed. This results in the inability to clear bacteria infections from the intestines. Inate and adaptive immunity is impaired. Nod2 induces autophagy through the NOD2 pathway. NOD2 is induced by NLP or bacteria infection, this promotes the delivery of NOD2 which enhances inflammation. Showing that if You have high NOD2 levels you would not want to induce autophagy. NOD2 prevents infection in cells which is mediated by ROS and MAPK pathways. NOD2 altered expression can lead to inflammatory bowel disease. Many cellular proteins interact with NOD2 directly and regulate it’s function positively or negatively. Among these proteins is Erbin. Erbin regulates Erbb2 if Erbin is inhibited Erbb2 levels can go up resulting in cancer growth. Centaurin B1 which I have no idea what it’s function is. Angio-associated migratory protein which is involved in endothelial tube formation and endothelial cell migration. It is involved in angiogenesis. Carbamoyl-phosphate synthase 2 is involved in the production of nucelotides in cells. Mitogen-activated protein 1 which helps down regulate NOD2. Heat shock protein 90 interacts with NOD2. HSP90 is involved in folding , intracellular transport and the degradation and maintenance of proteins. I have post on heat shock proteins like HSP90 and HSP70.

NOD deficiency. NOD2 is involved in maintaining balance between the microbiome and immune response. NOD2 deficiency results in loss of epithelium integrity, and increased susceptibility to intestinal inflammation. NOD2 deficiency can cause dysfunction in intestinal paneth and goblet cells. Deficiency increases IFN-y, and decrease ROS production which protects from infection so we need a balance because excess ROS can damage tissues in the body.

NOD2 upregulation. Vitamin D supplementation has been shown to increase NOD2 which helps to fight infection. Excess NOD2 can lead to rheumatoid arthritis, and systematic inflammation. Excess NOD2 has been linked to cardiovascular disease and pulmonary disease. NOD2 prevents inflammation in the eyes.

NOD2 deficiency causes low TH17 levels, inhibited immunity, and will be more prone to cancer. NOD2 is also involved in the detection and eradication of viruses.

Excess NOD2 causes systematic inflammation and sarcoidosis. Often times it is mistaken for cancer or copd. High NOD2 levels is a sign of infection.

Damage to the mucus membrane and intestinal tissue can cause it’s dis-regulation. This shows the importance of restoring mucus membrane and work on healing the gut.

Atg16L1

Autophagy-Related Protein 16-like Protein 1 – Deficiency in Atg16L1 impairs recruitment of Atg12-Atg-5 complex which impairs the engulfment of pathogens and cellular organelles during the process of autophagic catabolism. Atg16L1 defeciency cause Paneth cell dysfunction and increases inflammation. Atg16L1 causes high leptin and adiponectin levels. A deficiency in Atg16L1 leads to intestinal lesions. Leptin tells the brain we do not need to eat. Leptin increases inflammation in the body. High leptin levels lead to chronic fatigue. Leptin can cause Th1 dominance. Those with high IL-10 levels would want to avoid probiotics that increase IL-10 because leptin increases IL-10. Leptin causes mast cells to become more inflammatory. Leptin causes lower T regulatory cells which keep our immune system at homeostasis. Leptin can cause excess blood clotting (throbosis). Leptin can cause high blood pressure. Leptin increases estrogen levels. Adiponectin is a protein hormone involved in glucose levels and fatty acid breakdown. High adiponectin levels causes a loss of appetite it causes weight loss and works synergistically with leptin. Adiponecton decreases gluconeogenesis. It increases B-oxidation of fats. It protects against endothelial dysfunction. It increases insulin sensitivity. So you can see the importance of Atg16L1 homeostasis.

Mir223 restores autophagy and Atg16L1 homeostasis. Mir233 downregulates inflammation. Mir233 is reduced in sepsis. Mir233 increase HDL cholesterol levels. But Mir233 is upregulated in inflammatory bowel diseases. Increasing Claudin-8 inhibits Mir233 inflammatory effects.

ROS (Reactive Oxygen Species)

ROS or Reactive Oxygen Species modulates cellular function under normal conditions. ROS is produced during the process of oxidative phosphorylation and can be handled by instracellular antioxidants. Injury, toxins , vaccine injury, infection, and stress can cause an over production of ROS which can exceed the generation of antioxidants leading to oxidative stress which can cause a lot of damage throughout the body. It causes inflammation, cell damage and even cell death. When the mitochondria become dysfunctional this can cause a rearrangement of the cytoskeleton which is framework of the plasma membrane and effects the balance between kinases, and phosphatases which promotes the ability of microorganisms to enter the cell and contributes to many inflammatory diseases. Excess ROS increases the permeability of intestinal epithelial. When levels of ROS are normal it will induce autophagy and microphagy which reduces inflammation. Reducing ROS levels too low can have the opposite effect because it would prevent it from inducing autophagy and we would lose the protection it gives us from infection.

Antioxidants can reduce oxidative stress but when homeostasis is achieved a person should only take maintenance doses. Over use of antioxidants can promote cancer by protecting it from apoptosis it also increases our risk of infection by reducing ROS levels too low.

Xenophagy

Xenophagy is the clearance of pathogens regulated by autophagy. Reduces Xenophagy leads to alterations of intestinal microbiota. This leads to a higher rate of infection. The microbiotia induce xenophagy in basal paneth cells which is induced by INF-y to maintain intestinal integrity. This impairs sensing of intracellular micro organisms in the intestinal endothelial cells and contributes to the progression of inflammatory bowel disease. Showing the importance on healing the intestinal tract so that the mucus membrane can be restored. Prebiotic fiber and the tryptophan metabolizing gut microbiota increases IFN-y. The commensal strains of E Coli increases IFN-y. Lactobacillus Gasseri increases IFN-y. Bacteroides Fragilis increases IFN-y and has been found to protect from many types of infections. Butyric Acid must be present to maintain IFN-y homeostasis. So it would also be a good idea to make sure the butyrate producing microbes are established.

IRGM (Immunity Related GTPase Family M protein) – is involved in killing of bacteria, vacuolar trafficking and acidification, it is also involved in autophagy. It is involved in fighting mycoplasmas. Damage to the digestive tract can impair it’s function which wold make you susceptible to mycoplasma infection. Inflammation inhibits IRGM. Our digestive tract needs to be acidic. If it becomes to alkaline then it creates an environment that promotes infection and dysbiosis and we lose our commensal microbiota.

Learn the truth about vaccines.

This is not medical advice I am posting this for informational and educational purposes. Whether you vaccinate or not is up to you bad do your research. It can change your whole families life because vaccine injury is real and millions of dollars are awarded every year to victims of vaccine injury and families. Unfortunately some vaccine injury is so severe the family has to deal with a permanently severely disabled family member the rest of their lives which can take it’s tool on the family and death often occurs. Know the risk and make your decisions based on an unbiased and balanced view of the information.

vaccination

 

Wonder why so many children are getting cancer? Vaccinations and the poor kids don’t stand a chance because they get injected with them as soon as they are born.

https://iamajuicer.wordpress.com/2018/07/22/what-they-dont-want-you-to-know-about-cancer-and-why-so-many-children-are-getting-it/

Wonder why so many children are ill now days. Vaccinations and vaccine injury is not always obvious and can take years before it starts to present itself as an autoimmune issue. They will blame it on genes but that is not true. That is like saying that bullets do not kill and injure but it is the persons susceptibility to injury and death that has caused the injury or death. All vaccines injure 100% of the time. All vaccines contain harmful toxins and many contain aborted fetal tissue or animal tissue.

https://iamajuicer.wordpress.com/2018/07/13/identifying-vaccine-injury-and-its-cost-to-society/?fbclid=IwAR31kQpnSEUnkctCTzVwWzzVd3e4QyNG2IAO2Rwi4Sb2u4qf4y9ZYWawcuk

If you do research you will find that disease rates took a dramatic drop when better sanitation practices were implemented as man became aware of what caused illness. And also as nutrition became more available disease declined dramatically. Very shortly after vaccines were introduced disease has taken a dramatic climb and has risen every since because vaccines cause and spread disease they do not prevent illness. Vaccines have been found to be the cause of the new super bugs.

https://iamajuicer.wordpress.com/2018/06/17/vaccinations-spread-and-cause-disease/?fbclid=IwAR2mB73dNMaifJWl_a6Iamlbk5fPER6FOlWgvsqbr77rPAD6QgiUh4TVDF4

They renamed polio flaccid myelitis because they had realized toxins and vaccines were the cause of polio.

https://iamajuicer.wordpress.com/2018/10/08/cause-of-flaccid-myelitis/?fbclid=IwAR30QOJKfVxy5HOn0eXfrDhIdfVbmUWtGzzDXz_pYFUgr_JbvcKcFVJXNTo

Germ theory which vaccines are based on is incorrect and has been proven to be, so vaccine research is flawed from the start. How our immune system works is nothing like we are taught in school.

https://iamajuicer.wordpress.com/2018/08/18/germ-theory-and-terrain-theory-are-wrong/?fbclid=IwAR1gJ2WxwcyTHtnMh0QDy0WCUKvIxOMWnF7jJR_E77bWZETUaEDqewxizFA

Vaccines have major toxins. Some toxins they put in vaccines require a hazmat team to clean them up if they are spilled and have been banned in many other products but they permit their use in vaccinations. Toxins alter our genes but then the vaccine producers will blame a persons genes when they have an adverse reaction to them.

https://iamajuicer.wordpress.com/2018/09/02/1303/?fbclid=IwAR2ntDwxYhhYhCPYy1pHAhQ8ti9q5XN097MqvxWBpqIAzU3F2sKuQfWBp6I

True cause of illness and things that may help.

This is not medical advice I am posting this for educational and informational purposes.

 

 

I have a lot more to add to this but need a break and then I will finish it. I am going to add the things that negatively impact health and how it happens. Some of it I have covered but I have not covered the how part of it I only covered things that may help correct it.

Because probiotics can cause sepsis if you have ulcers or your gut is too porous I consumed a lot of mucilage and took bismuth in order to make sure my gut healed enough that would not happen.

To fully grasp the information here and to grasp the information in the links you will need to understand that Germ Theory and Terrain Theory have been proven wrong and that is why our Facebook group Synergistic Health decided we need a new theory “Enviroment and Biome Theory of Health”

https://iamajuicer.wordpress.com/2018/08/18/germ-theory-and-terrain-theory-are-wrong/

 

This article discusses how our microbiome effect the whole body even the blood brain barrier.

In this post I am going to try and show how our environment, biome of our environment and our won biome effect our health. This shows that our Facebook group Synergistic Health is correct with our theory “Environment and Biome Theory of Health” is correct and that germ theory and terrain theory are incorrect. Learning this will help people understand why their genes have very little impact on their health compared to the above mentioned things. I also list the things that may be able to correct them.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102499/

In all the research I have read gut diversity increases health and longevity and is found to be a commonality in centurions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051225/

There is a myth we should alkaize our digestive system must be acidic and alkalinity cause pathogenic and hydrogen sulfide producing bacteria to increase. This causes sulfation issues and increased ammonia getting the body stuck in a cycle. Bile and digestive enzymes become inhibited which cause high estrogen levels and copper will become biounavailable. You must break this cycle by getting ammonia levels down. BH4 levels get low when this happens eating protein increases ammonia levels. Short chain fatty acids balance our T cells so it is important to increase SCFA producing bacteria. I did a blog post on reducing ammonia levels (alkalosis). I did a post on reducing akalosis. I also did a summary of my notes which covers many of these things. If you search for akalosis and summary you should be able to find the information.

Fiber especially inulin increases the good gut bacteria. Exercise also increases our good gut bacteria. Reducing stress or learning to deal with stress increases our good gut bacteria. Ghee is high in butyrate which increases our good gut bacteria.

Egg and milk allergies indicate high Staphylococcus Aureus levels. This is caused by low microbiota that breaks up biofilms and produces natural antibiotics. This can also be caused by low lactobacillus paracasei, lactobacillus adolenscentis and lactobacillus rhamnosis levels.

I do not mention the strains that produce histamines because they are usually not a problem unless something is wrong in the body and they are needed for gut and body health. Avoiding the foods that cause them to produce histamines is more effective. Fermented foods, and aged meats and many cheeses will cause them to produce histamines. Some cheeses like Gouda and Parmesion have species of microbes that reduce histamines. This is why overconsumption of them can cause constipation because histamine stimulates stomache acid production. Those with low stomach acid production may benefit from eating foods that increase histamines.

An imbalance in our gut bacteria can lead to the production of high substance P levels which leads to systematic inflammation. If levels get high enough a person will start to lose their hair, they will get burning in their skin especially at night. The burning mostly occurs in the scalp and down the spine. I posted on how to reduce substance P.

When replacing a microbe you may be lacking it is normal to experience cramps and bloating until they get established. Taking the same probiotic daily can cause gut dysbiosis which is as bad as when candida goes pathogenic and can cause candida and H Pylori to switch from commensal to pathogenic. Probiotics should be alternated and one should take a break from them to let the microbial community balance out.

Most Bifidobacterium and Lactobacillus have some oxalate degrading abilities. The microbiota that produce vitamin B12 need chromium to be present to produce it.

Exercise increases our good gut bacteria. Stress and trauma increase our bad bacteria so it is very important to learn to meditate , pray and not to dwell on things you can do nothing about and do your best to get over trauma and do not hold grudges or be resentful or hateful. When we have a lot of negative emotions it increases the gut bacteria that increases adrenaline and it can tax our adrenals.

Diets rich on complex carbohydrates have been shown to prevent infection from food born pathogens. Processed sugar has been found to dramatically increase risk of infection from ford born pathogens.

Often times a persons microbiome is influenced by their sexual partners. Their sexual partner may have different metabolic factors so could appear to be unaffected. Usually a person sexual partner should be treated for dysbiosis or infection also to prevent constant reinfection or constant microbiome disruption.

Galacto-oligosaccharides increase absorption of nutrients, and increase the beneficial bacteria that are important in health mental health and cognition. It prevents constipation and helps protect from food born pathogens. It increases the microbiome that reduces anxiety and pain. It is derived from raw milk and is destroyed during pasteurizing. It also decreases the risk of pulmonary infections. It reduces almost all inflammatory markers in the body. It reduces intestinal inflammation. Galacto-oligosaccharid and fructo-oligosaccharid helps to prevent diabetes.

Our bodies secrete FUT2 to modulate our immune system and to keep our good microbiome health. Many things can make us deficient in FUT2 enzymes which causes a loss of our good gut microbiome and can lead to inflammatory bowel diseases and gut dysbiosis. Fructooligosaccharide and oligosaccharides can replace FUT2 until it is corrected. This is can also result from a deficiency in the microbiota that stimulate IL-22

A loss of our gut microbiome can cause raised zonulin levels which results in many food intolerances, metabolic issues , increase susceptibility to infection and if not corrected can lead to acidosis or alkalosis. Zonulin regulates gut permeability if levels get too low we can develop malabsorption issues. If zonulin levels get to high we can develop many health problems. It can also lead to interstitial cystitis and damage the blood brain barrier which results in the loss of protection of the brain and can lead to infection , encephalopathy and even chira which is a life threatening condition. Increased zonulin levels causes depression, anxiety and can even cause paranoid delusions and psychosis. Mold toxins can increase zonulin levels. BT Toxin found in GMO increase zonulin levels. Farm chemicals which are found to be heavy in our food increases zonulin levels especially glyphosate and glufosinate. It is very important to eat organic when possible. A diet high in fiber and resistant starches increases the microbes that reduce zonulin. Oddly our sterile lifestyles have caused a loss of the microbes that keep zonulin levels balanced. They have found those who are in nature and work with the soil a lot get the good microbes that keep zonulin levels balanced. Unfortunately glyphosate and glufosinate are killing those microbes in the soil which is making it more and more difficult for a person to get those microbes. Endotoxins and mycotoxins increase zonulin levels making us more prone to leaky gut. Leaky gut causes systematic inflammation which can lead to autoimmunity. Butyrate producing gut bacteria reduce zonulin levels helping to prevent leaky gut. Butter and raw milk is high in butyrate. Inflammation causes increased zonulin levels so microbes that reduce inflammation will decrease zonulin. When zonulin levels are how toxins the body would not absorb but would get excreted are easily absorbed which causes high heavy metal and other toxins levels in the body. High zonulin levels also result in food particles entering the blood stream which causes a lot of food sensitivities. This can be corrected by addressing the leaky gut. When zonulin levels are high it increases mast cell degranulation which can lead to mast cell activation syndrome or mastocytosis. This increases histamines leading to autoimmunity and allergies. This also will correct itself once zonulin levels are reduce. Those with high zonulin levels should avoid gluten and gliaden until it is corrected because they raise zonulin levels. High zonulin and high inflammation levels has been linked to just about all types of chronic illness. Inflammation can cause high zonulin levels, high zonulin levels can lead to inflammation creating a cycle that is difficult to break. Inflammation disables the immune system and is why so many illnesses like tick born illness, candida and many other infections are becoming epidemic. Almost all illness can be link to zonulin.

https://www.sciencedirect.com/science/article/pii/S2352551717300288

https://www.physiology.org/doi/full/10.1152/physrev.00003.2008

https://www.frontiersin.org/articles/10.3389/fmicb.2017.01936/full

https://www.tandfonline.com/doi/pdf/10.1080/21688370.2016.1251384

Our gut microbiome regulate our zonulin levels which regulates the tight junction layer. When zonulin is high then we develop leaky gut which causes chronic illness and even effects our brains. Our gut bacteria even regulate our HPA axis. Microbes that increase IL-10, T regulatory cells and reduce inflammation will reduce zonulin levels which will restore the tight junction protein layer. Also stress increases zonulin so microbes that reduce stress will also decrease zonulin levels.

https://www.tandfonline.com/doi/pdf/10.1080/21688370.2016.1251384

https://link.springer.com/article/10.1007/s00394-018-1784-0

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288588/

Our sterile lives have added to the increase in zonulin levels. Also nutrient deficiencies cause by over farming land and chemicals like glyphosate and glufosinate that chelate nutrients are causing nutrient deficiencies which increases zonulin. This indicates the the biome of our environment is also important for our health. It also indicates that our environment itself can influence our health.

http://www.pnas.org/content/106/39/16799.long

Nutrient deficiencies also stimulate zonulin and so do bad fats and excessive meat consumption. Excess vitamin B12 increases zonulin levels. I do not supplement with it, I nurture my gut microbiota that produce it and I make sure I get cobalt which they need to produce B12. On the other end of the scale zonulin deficiency can result in the inability to absorb nutrients. This shows the importance of learning to achieve homeostasis. I cannot find studies showing that inhibited zonulin causes malabsorption but I have noticed those who have high levels of the bacteria that inhibit zonulin and low levels of the ones that stimulate zonulin have malabsorption issues.

https://www.sciencedirect.com/science/article/pii/S0041134514008045

High zonulin levels can lead to decreased intestinal motility which causes the food to sit in the digestive tract and ferment instead of digesting. This increases the ammonia, hydrogen, sulfide and methane producing microbes which raises zonulin levels even higher. If I ever get a chance to write a book I will cover it in more detail. Once this cycle starts it is very hard to break and a person will not be able to absorb nutrients because their food is not getting broken down properly.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111132#s4

So all this being said the bigger the variety of gut microbes we have the more balanced our zonulin becomes.

Butyrate producing microbiota increase TGF-B which is needed to prevent some commensals from becoming harmful. A deficiency in TGF-B can lead to inflammatory bowel disease which can cause bile to be inhibited. The most important of these are F Prausnitzii, Clostridium Leptum, Eubacterium Rectale and Roseburia. If deficient in IL-10 or TGF-B the microbiota that stimulates bile will become pathogenic in nature IL-10 and TGF-B work together to keep them in check so they continue to function properly. I discuss bile in more detail at the end of this article.

https://link.springer.com/article/10.1007/s00535-017-1350-1

https://www.tandfonline.com/doi/full/10.3109/0284186X.2015.1054949

Raw potatoes, inulin, chickpeas and other legumes feed the gut bacteria that prevent gliaden and gluten intolerance. Too much of these can increase the glucose levels in the blood. That may be good for those with malabsorption but high glucose levels can lead to cancer and other health problems.

Increased CB1 receptor activation causes leaky gut which can lead to food intolerances from our gut becoming too porous. This can lead to increased LPS levels which can lead to endotoxemia and sepsis. Increased zonulin also does this. Stress increases zonulin.

The PH of the gut and bladder should be between 4 to 5. The lower the number the more acidic the high the number the more alkaline. We do not want alkaline it causes infection and gut dysbiosis. Candida and H Pylori will go from commensal to pathogenic.

Bloating can be from taking too much of a certain probiotic which can lead to dysbiosis , inflammation, ulcerations, or high histamines. High histamines will cause acid reflux. Low histamine inhibits bile and will cause bile reflux constipation and low stomach acid production. If you have low histamines fermented foods will increase the histamine producing bacteria but be cautious do not increase them too far. We can also become bloated if candid or H Pylori go from commensal to pathogenic.

Increased gut permeability (leaky gut) can lead to bone loss, autoimmunity, and many metabolic issues.

Our gut bacteria need carbohydrates but many avoid them. There are good carbs and bad carbs.

A microbiotia accessable carbohydrate diet increases beneficial bacteria that produce short chain fatty acid. This consist of fiber and carbohydrates. This increases the bacteria that produce short chain fatty acids. If we do not produce enough SCFA we will become constipated and bile production will become inhibited. This will also happen if we develop malabsorption from having high bacteroidetes, methane producing and sulfur digesting bacteria. They contribute to malabsorption, constipation and inhibited bile production from a lack of SCFA in the body. Our blood glucose levels will also become very low and we may develop high insulin levels. Clostridium infection is also a major cause of this and indicates we are lacking the microbiota that protect us from it. This can cause a cycle that is hard to break because bile is needed to prevent clostridium infection.

High histamines usually indicates low bifidobacterium levels. Bifidobacterium degrade histamines. Low Bifidobacterium can cause weight gain in some people and can lead to anxiety, difficulty sleeping and difficulty concentrating. Our histamine degrading bacteria need vitamins A,C, E and Zinc. Bifidobacterium which there are many species produce folate. Most Bifidobacterium increases IgA which prevents food intolerances and allergies. Bifidobacterium also break down gliaden. Excess gliaden can raise zonulin levels leading to the tight junction layer becoming more permeable resulting in leaky gut.

Lactobacillus needs vitamin A and consuming it has been shown to restore lactobacillus. Most lactobacillus prevent candida and fungus infections. Most Lactobacillus prevent lung infection. Most Lactobacillus increase IL-10. IL-10 is needed for commensalism. Those deficient in Lactobacillus will be extremely underweight.

https://pdfs.semanticscholar.org/b2c3/c191fc3c8efbd745d5583d6be940a4dcae06.pdf

Most probiotics should be taken with an oligosaccharide. They help feed them and get them established. Pectin also protects the good bacteria helping it to thrive. Olive oil has been found to prevent them from making TMAO. If TMAO levels get too high we can develop a fish like smell, diabetes and/or cardiovascular disease.

Lactobacillus Reuteri increases oxytocin which helps keep us calm and helps prevent depression. It also helps prevent diarrhea. It increases intestinal absorption of nutrients. It prevents cavities and promotes dental health. It protects against pathogens and parasites. It has been shown to help with autism. L Reuteri produces food need by most of the other commensal bacteria. It requires sugar to produce the food the commensal microbes need. L reuteri also help prevent asthma. Helps restore normal vaginal and bladder microbiome. If you are sensitive to sugars and starches it could be an indication you are deficient in L Reuteri. L Reuteri breaks down sugars and starches. A deficiency in Lactobacillus Reuteri can also contribute to milk allergy and a lower resistance to pain. It prevents gingivitis and periodontal disease. It helps keep H Pylori commensal. L Reuteri improves the production of bile.

Clostrium Leptum has been found to be low in those with inflammatory bowel disease and Chohn’s disease. It breaks down carbohydrates and produces butyrate. It reduces inflammation.

I believe L Reuteri and L Fermentum are the same species. Often times research papers state that they are the same species.

Lactobacillus Fermentum found in raw goats milk protects from urinary tract infection and food born pathogens. It has been shown to increase other lactobacillus bacteria. This would help those who have difficulty gaining weight. It is resistant to most antibiotics and has been found to transfer that ability to the other but microbes. This also would help with lactos intolerance. L Fermentum prevents skin rashes and eczema By increasing TH1. It prevents IgA related allergic disease. L fermentum helps prevent urinary infection. Low I IgA levels are common in inflammatory bowel disease and those who have malabsorption disorders. Reduces endotoxins. Helps protect from cavities and gingivitis.

Bacteroides Vulgatus increases bile production, if levels are low a person is susceptible to inflammatory bowel disease. If levels get too high a person will develop celiac disease. This occurs if a person is lacking the microbiotia that stimulate IL-10, SMAD3 and TGFB.

Pediococcus pentosaceus prevents clostridium infection of the digestive system by reducing zonulin. This would improve bile production. It also reduces inflammation. It produces natural antibiotics that fight bacteria.

Bacillus Coagulins prevents lactose intolerance. Helps break down food better increasing nutrient absorption. Helps prevent diarrhea. Prevents gas, bloating and intestinal inflammation. Helps prevent constipation. Reduces endotoxins. Improves bladder and vaginal health. Helps keep H Pylori commensal.

Bacillus Subtilis produces food needed by the other commensal microbes has been shown to balance the gut microbiome. It prevents gastrointestinal and urinary tract infection. It is found in soil. It stimulates IgM, and IgG which important part of immune function. Protects the DNA and has antioxidant properties. Helps prevent diabetes and cardiovascular disease. If it is supplied with lactulose which is found in raw milk but destroyed during pasteurization it will prevent constipation. It reduces inflammation and has been shown to reverse irritable bowel disease. It Balances our T cells which would prevent allergies and autoimmunity. It prevents H Pylori and Candida from becoming pathogenic. Reduces endotoxins and heals the liver and kidneys. It prevents skin rashes and lesions. It increases our ability to tolerate heat. Helps break down phytic acid preventing it from being and antinutrient. B Subtilis has been shown to reduce blood pressure and prevent atherosclerosis. B Subtilis communicates with the body to let is know what is going on. It kind of acts like a soldier and a nurse. It stimulates IFN-y in spleens of mammals which is an important part of the bodies ability to fight infections. Seems more important for fighting infection then dendric cells and natural killer cells. IFN-y prevent viruses from being able to adhere to cells. Increasing IFN-y increases CD8 molecules. Those who are TH1 dominant should avoid this strain it increases TH1.

https://iai.asm.org/content/75/3/1167

Lactobacillus sanfranciscensis helps degrade phytate preventing them from being and antinutrient. Decreases gut permeability and prevents obesity. Reduces symptoms of inflammatory bowel disease. It is found in raw sour bread dough.

Lactobacillus pentosus found in fermented olive products. It helps prevent food born pathogens. It helps break down carbohydrates. Helps reduce symptoms of lactose intolerance. It can break down a wide variety of sugars and carbohydrates.

Lactobacillus Salivarius reduces histamines. Protects the throat, mouth and nasal cavities from infection. It helps prevent cavities. They help keep the ph of the intestines balanced. It helps with nutrient absorption especially folate. It reduces nausea, bloating, cramping and inflammation in the digestive system. It protects us from food born pathogens. It protects us from getting strept throat and halitosis. It lowers cortisol levels and reduces stress and anxiety. L Slivarius increases endurance. Helps prevent lactose intolerance. It prevents flatulence. Has been shown to protect the pancreas. Has been shown to reverse dermatitis.

Oxabacter Formigenes reduces oxalates and reduces pain. It is the primary oxalate degrading bacteria in the gut.

Lactobacillus Paracasei inhibits infection and helps reduce ammonia producing bacteria. It is a subspecies of Lactobacillus Casei which has many of the same benefits. It also prevents anxiety but not depression. L paracasei especiall ssp Casei prevents obesity. L Casei reduces the duration of infections. L Paracasei helps prevent allergies. L paracasei and ssp L Casei should not be taken by those with high histamines. It prevents halitosis and cavities. It has been shown to protect the nasal cavities, mouth and throat from infection.

L Casei protects us from pathogens that cause diarrhea and antibiotic induced diarrhea. It improves colon health and inceases the commensal bacteria that help prevent depression and anxiety. Helps protect the gums from infection. Has been shown to protect the health of the pancreas. Increases IL-10 and TGF-B.

Lactobacillus Casei ssp shirota prevents constipation. Increases serotonin. It improves mood and prevents depression. It has the best long term effects at improving mood.

Lactobacillus Brevis prevents urinary and intestinal infection by regulating the PH of the digestive system and renal system. It helps keep it from getting too akaline. Lactobacillus Brevis improves cellular immunity it protects the gut from excess bile acids and keeps H Pylori commensal. It produces natural antibiotics that protect the gut from pathogens.

Streptococcus Thermophilus is needed by most of the gut bacteria to get established especially lactobacillus debrueckii. S Thermophilus helps with lactose intolerance. It prevents cavities and infection in the nose, throat and mouth. Helps prevent inflammatory bowel diseases. It accelerates healing in the gut.

Lactobacillus Debrueckii is needed to establish the commensal microbiome and to prevent C Diff infection. It also prevents inflammation. It is found in butter milk. It also helps keep H Pylori commensal. It helps degrade milk proteins. It also helps prevent liver disease. L Debrueckii also prevents fungus infection. It also prevents obesity.

lactobacillus Plantarum is needed to balance our gut bacteria which helps prevent dysbiosis. It also helps prevent diabetes. Helps prevent candida and fungus infections. Helps prevent inflammatory bowel diseases. It reduces HIV, enhances memory and reduces brain inflammation. Reduces abdominal pain.

Saccharomyces Boulardii helps prevent autoimmunity, protects from diarrhea caused by pathogens. Helps keep H Pylori commensal. Helps prevent inflammatory bowel. Saccharomyces Boulardii helps with gluten intolerance and reduces symptoms of SIBO.

Bifidobacterium bifidum helps in the production of many B vitamins. Prevents celiac diseas, milk allergies and many other food sensitivities. Reduces histamines. Improves immune function. Prevents ulcers and diarrhea. It is important for vaginal homeostasis. Has been shown to reduce symptoms of inflammatory bowel diseases. Prevents constipation and lung infection. Prevents pouchitis and infections in the lining of the intestines. Has been found to improve immune function. Prevents eczema. It also produces the B vitamins common to Bifidobacterium but also produces vitamin K2. It helps those who do not produce enough lactase because it breaks down lactose. Increases red blood cell production helping to prevent anemia. Has been shown to reduce the severity of the flu and common colds.

Bacillus Coagulans found in the soil , it improves bowel movements, helps with inflammatory bowel diseases, reduces bloating and pain in the digestive system. It also decrease the inflammatory C-reactive protein which is high during infection. It reduces intestinal gas. Reduces the risk of infection especially by influenza. Has been shown to reduce arthritis symptoms. It has been shown to help with gluten intolerance and allergies. It has been shown to reduce symptoms of SIBO. It has been shown to prevent food born pathogens. Is effective at fighting a broad range of pathogens. It reduces symptoms of arthritis if it has an adequate supply of inulin.

Saccharomyces Cerevisiae reduces oxidative stress and free radicals including hydroxy radicals and prevents excess nitric oxide production. Helps prevent iron toxicity. It stimulates the good inflammatory cytokines while inhibiting the bad ones. It helps in developing humoral immunity. Can reduce candida infection but if taken in excess will cause symptoms that are exactly the same as candida infection and is often times more common in those who are believed to have candida infections in the bladder. It helps those who have phenylketonuria or proteinuria it breaks down proteins like phenylalanine. Saccharomyces Cerevisiae prevents acne.

Lactobacillus gallinarum prevents urinary tract infection and reduces oxalates. It reduces symptoms of allergy. It helps break down phytic acid preventing it from being an antinutrient.

Bacillus Subtilis found in soil protects and heals intestinal epithial cells. It is improtant in the proper absorption of nutrients. If deficient in B Subtilis you will suffer from Malabsorption syndrome. It helps keep our T cells balanced. It is needed for digestion of carbohydrates. Has been shown to keep H Pylori commensal and fight food born illness. Has a broad range of antimicrobial properties.

Lactobacillus Helveticus is found in cheeses like parmesian, cheddar, swiss cheeses, buttermilk and cheddar cheese. Protects the gut health and is a butyrate producing bacteria. It reduces neurological inflammation and restores cognitive function. It helps prevent anxiety and depression. It improves sleep and prevents lung infection. It reduces parathyroid hormone and improves calcium metabolism. It improves learning and cognition. It fights candida and prevents dermatitis. It fights cancer and reduces inflammation. L Helviticus also prevents lung infections. It is and ACE inhibitor so prevents high blood pressure. It is important for whole body health and protects the liver and kidneys. It helps prevent lactose intolerance. It reduces anxiety and promotes the feeling of well being. It prevents mood swings and aggressive behavior. It helps prevent depression.

Bifidobacterium Longhum helps prevent anxiety and depression, and improves cognitive function, it helps prevent viral infections and symptoms of ulcerative colitis. B Infantis is a subspecies which has been shown to protect against polio. B Longhum protects the lungs from infection. It prevents food born illness and prevents candida from becoming pathogenic. It reduces symptoms of gout and prevents inflammation. It prevents allergies and celiac disease. It reduces endotoxins and prevents fatty liver disease. It increases biotin levels. It reduces bloating in the gut especially ssp Infantis. B Longhum improves sleep and prevents anxiety. Reduces depression caused by stress by reducing cortisol. It prevents liver disease and produces B12 and Folate.c It improves bone health and fights cancer. It decreases TH1 and TH17 cytokines. B Longhum also reduces aggressive behavior. B Longhum improves nutrient absorption. Reduces histamines. B longhum stimulates the vagal nerve.

B Infanis increases tryptophan. Decreases bloating. Bifidobacterium Longhum also helps prevent lactose intolerance. It detoxes serotonin metabolites. It decreases adrenalin levels and restores the HPA axis. It reduces inflammation and increases lifespan. It prevents ulcers. It helps prevent lactose intolerance. Increases IL-10 and IL-1B which seems contridicting but IL-1B is needed to increase intestinal motility. IL-10 keeps IL-1B from causing inflammation and immune issues.

Bifidobacterium Infantis increases tryptophan, serrotonin and GABA precursors. Helps prevent inflammatory bowel diseases. B Infantis increases T regulatory cells which helps keep the immune system balanced. B Infantis promotes the production of IgA which is usually low in those with malabsorption and inflammatory bowel disease.

B Infantis reduces histamines. B infantis decreases intestinal bloating, pain and gut distention (enlarged or inflammed). B Infantis increases tolerance to pain. B Infantis has been shown to protect the health of the pancreas.

Bifidobacterium Breve helps protect from food born pathogens and diarrhea. It also helps prevent allergies. Has been shown to improve intestinal health. Reduces anxiety and improves cognition. Reduces histamines. It helps the body absorb nutrients. It reduces bloating and inflammation. Prevents obesity.

Bacteroides Thetaiotaomicron secrete natural antibiotics which keep the gut balanced. It is also responsible for innate immunity in the intestines. It reinforces the mucous membrane. It reduces inflammation. It also helps break down carbohydrates. Prevents constipation and improves bile production. But high levels can promote Clostridium infection.

Bacteroides Ovatus helps break down carbohydrates and feeds other commensal bacteria. It breaks down the most difficult fiber that none of the other microbiota can.

Lactobacillus Rhamnosus helps prevent anxiety and depression by upregulating GABA. L Rhamnosus also prevents lactose intolerance, asthma and allergies. It also prevents skin rashes and eczema. L Rhamnosus also prevents urinary infection. Helps restore normal vaginal and bladder microbiome. Helps prevent candida and fungul infections. Helps prevent inflammatory bowel diseases. Reduces oxalates. Prevents food sensitivities. Breaks down histamines. Reduces endotoxins and inhibits biofilm formation. It simulates phagocytosis which helps fight infection. Phagocytosis is inhibited in those with immune deficiency. Reduces histamines. Rhamnosus improve bowel movements by increasing intestinal motility. Has been shown to prevent chronic fatigue.

Lactobacillus Acidophilus prevents excessive weightloss and reduces inflammation. Has been shown to reduce symptoms of arthritis. L Acidophilus increase CB2 receptor expression. Prevents urinary and bladder infection and helps keep the ph of the bladder and intestines balanced. Helps prevent candida and fungul infections. Helps prevent inflammatory bowel diseases. Prevents celiac disease, milk allergies and food sensitivities. L acidophilus helps with FODMAP intolerance and has been shown to reduce SIBO. It reduces pain by stimulating the opioid receptor. Helps prevent acne. Helps prevent allergies and food intolerances. Helps prevent infection in the bladder and intestines by balancing the ph. If we become too alkaline it promotes pathogen growth. It also prevent vaginal infections. Has been shown to protect the health of the pancreas. Increases IL-10.

Mycobacterium Vaccae helps prevent brain inflammation, anxiety and depression. It also improves cognitive function. It is found in healthy soil in forest among decaying folage. Supposedly eating leaves from a plant can give you this. It induces a strong T cell response when first establishing in the body and then slowly declines as it gets established. Once established it increases T regulatory cells. It helps fight tuberculosis.

Almost all bifidobacterium prevent depression and anxiety but can cause weight loss so those who are under weight my want to be cautious in taking these in excess. Red Wine increases Bifidobacterium. The bifidobacterium also decreases adrenalin levels.

Sophora has been found to increase most of the bacteria that prevent anxiety and depression.

Lactobacillus Iners promotes vaginal dysbiosis so should be avoided , high levels can cause miscarriage. It increases risk of contracting sexually transmitted diseases. One good thing about it is it prevents HPV infection.

Lactobacillus Jensii reduces the risk of contracting sexually transmitted diseases and renal infection. It helps with the break down of milk. It reduces the population of other Lactobacillus which can help with obesity. Lactobacillus Jensii produces chemicals that inhibit HIV. Helps restore normal bladder and digestive microbiome. Helps protect from HPV infection. It helps maintain the proper PH of the intestines and the bladder.

Lactobacillus Crispatus causes weight loss in those who are obese and protects from infections in the renal system, bladder and prevents sexually transmitted diseases. It helps keep the ph of the bladder and digestive system balanced. Helps restore normal gut and bladder microbiome. Helps protect from HPV, HIV and many other types of infection. It prevents vaginal odor.

Lactobacillus Johnsii requires purines to survive so needs purine producing commensals or purines consumed in the diet. It produces natural antibiotics that protect the gut from infection and prevent H Pylori and Candida from becoming pathogenic. It has been shown to thicken the mucous membrane in the gut and helps heal peptic ulcers. It restores the proper number of IgA, IgG and CD8+ cells which are low in tick born illness and inflammatory bowel and malabsorption disorders. It helps prevent skin lesions. It has been shown to reduce diabetes and even reverse it in some. L Johnsii prevents insulin resistance and allergies. It also prevents vaginosis. Those with interstitial cystitis or high TH17 levels would want to avoid this one because it increases TH17 levels along with COX2 which is high in interstitial cystitis, psoriasis, and lupus. It would help restore nutrient absorption in those with malabsorption.

Lactobacillus Kefiranofacians is found in kefir and fermented milk. It prevents cavities and biofilm formation. It does not survive in the gut long so you would have to gargle with it. It also helps with constipation. It stimulates the intestines to produce more mucin increasing the mucous membrane in the gut which helps with colitis. Those with high TH1 levels would want to avoid it because it increases TH1 levels.

Lactobacillus Kimchii increases phagocytosis which would not be good in those with a hyper immune system but would help those who have an inhibited immune system. It is found in kimchi. Kimchi also contains Lactobacillus Sakei which inhibits biofilm formation.

Lactobacillus Plantarum has potent antioxidant abilities. It helps maintain proper intestinal permeability and helps with malabsorption disorders. It produces antimicrobials that fight gram positive and gram negative bacteria. It accelerates gut repair. It helps with chron’s and inflammatory bowel disease. It reduces skin rashes and eczema. It has been shown to help with diabetes. It prevents diabetes and high blood pressure. L Plantarum also prevents biofilm formation. L Planatarum increases muscle mass, muscle strength and endurance. Helps prevent candida and fungul infection. Helps prevent inflammatory bowel diseases. Reduces oxalates. Breaks down histamines. L Plantarum improves intestinal epithial health. It produces L-Lysine which improves our bodies ability to use calcium. It has been shown to improve mental health. It is improves the absorption of nutrients into the body. It helps remove toxins from the body.

Lactobacillus Pontis increases NOD2 which fights viruses but is not good for those with inflammatory diseases or inflammatory bowel disease.

Bifidobacterium Adolenscentis helps break down milk proteins, promotes normal bowel movements, produce many of the same vitamins that most Bifidobacterium produce which includes B1, folate, B12, biotin and riboflavin. It also produces vitamin C but not in high enough amounts to provide the body with adequate levels of vitamin C. It like most Bifidobacterium dephosphoralizes phytic acid. Which prevents the antinutrient effect of Phytic Acid. If a person is low in Bifidobacterium then phytic acid will deplete their bodies of nutrients. It helps fight Coxsackievirus and other viruses. If a person is deficient in Bifidobacterium they are more prone to Norovirus infection. It along with most bifidobacterium prevents obesity, cardiovascular disease and diabetes.

Streptococcus Salvarius prevents infection in the throat nose and mouth. It also produces natural antibiotics that kill harmful bacteria. Prevents food allergies. It also prevents lung infection.

Streptococcus Mitis prevents infection in the throat nose and mouth.

E Coli Nissle prevent E Coli infection, prevents halitosis, helps prevent infection in the mouth , throat and nose. Helps with inflammatory bowel diseases. E Coli Nissle protects us from it’s pathogenic cousins. It also protects from other food born illness.

Lactobacillus Salvarius prevents cavities and prevents biofilm formation and prevents dental plaque. Helps prevent fungul infection and candida.

Lactobacillus Coagulans (Lactobacillus sporogenes ) helps prevent inflammatory bowel diseases. Has been shown to prevent diabetes. It enhances protein absorption and increase muscle healing, improves muscle recovery time and increases endurance. It inhibits fibrosis which would help with fatty liver disease and COPD. It increases butyrate producing bacteria. It decreases abdominal pain. It requires oligosaccharides. It improves bowel motility which prevents constipation. It reduces symptoms of inflammatory bowel diseases. It helps improve feeding tolerance. In other words it helps restore your appetite.It prevents parasite infections and has been shown to protect against the flu and adenovirus. It has been shown to reduce vaginosis. It also protects from many pathogens that cause diarrhea.

Lactobacillus Gasseri prevents halitosis. Helps restore normal bladder and gut microbiome. Reduces oxalates and histamines. Helps protect from HPV infection. It reduces menstrual pain. Reduces allergies and asthma. Helps break down phytic acid preventing it from being and antinutrient.

Bifidobacterium Animalis prevents food allergies and reduces oxalates. Prevents constipation speeds up food transit time. It prevents bloating, nuero inflammation, oxidative stress, and increases serrotonin, dopamine and norepineprhine by inhibiting MAO activity. Prevents obesity and anemia. It protects from polio and rotavirus. It reduces the length of the flu and prevents lung infection. I reduces allergies but increases TH1 levels. It reduces inflammation and increases T regulatory cells. It increases good gut microbes and decreases the bad. Improves digestive health. Prevents diarrhea and constipation. Helps with colitis and inflammatory bowel disease. It enhances immunity. It helps prevent celiac disease. It degrades oxalates. It improves nutrient absorption. It reduces stress hormones helping to reduce anxiety.

Bifidobacterium Adolescentis prevents food allergies and reduces oxalates. It prevents diarrhea from pathogens and prevents constipation. It helps protect from the rotavirus. Prevents asthma. Inulin increases B Adolescentis. It is fed by F Prausnitzii. It helps reduce fatty liver disease.

Akkermansia Muciniphila helps prevent obesity and helps to produce short chain fatty acids and is usually low in those will malabsorption issues. Deficiency in Akkermansia Muciniphila can lead to diabetes. Akkermansia Muciniphila also protect us from inflammation. It is important in homeostasis in the gut. It also produces oligosaccharides which feed our good gut microbes. It helps produce SCFA which are needed by the body and our microbiome. It helps maintain the shape and health of the mucous membrane in the gut. Low levels of Akkermansia Muciniphila results in a thinner mucous membrane making us more prone to infection and inflammatory bowel diseases. A deficiency in Akkermansia can result in appendicitis. Arabinoxylin, Inulin , fructoligosaccharide, oligofructose increases Akkermansia. Polyphenols in pomegranate, grapes, grape seed extract , and navy beans increase Akkermansia. Cod liver oil also increases Akkermansia. When there is a wound in the gut Akkermansia will go to the site of the wound and signal the body it needs to repair that area. This is one of the most important microbes for gut health. If we are deficient in it bacteroidetes leves get to high, bile production becomes inhibited and our bodies do not secrete pancreatic enzymes. I discuss the consequences of high bacteroidetes levels at the end of this post. Increased CB1 receptor activation reduces Akkermansia, inhibiting CB1 receptor increases Akkermansia but inhibiting CB1 increases depression and anxiety. Akkermansia needs Faecalibacterium Prausnitzii and vice versa. There is research showing if Akkermansia levels get too high it can increase zonulin levels so though it is a key mcirobiota in the regulation of our health homeostasis should always be the goal.

Clostridium Butyricum help prevent many food born pathogens, helps produce short chain fatty acids, it prevents diabetes and helps keep the sulfur digesting and ammonia producing bacteria like Bacteroidetes and Firmicutes from getting too high. If those are high a person can develop diabetes, malabsorption from inhibited bile production and inflammation. It prevents insulin resistance. Clostridium Bytyricum also protect from bartonella.

Faecalibacterium Prausnitzii Faecalibacterium a deficiency can lead to irritable bowel syndrome. Produces butyrate from fiber. A deficiency in F Prausnitzii can lead to asthma, obesity, depression ,Chohn’s disease and inflammatory bowel diseases. A deficiency in this can lead to high TH17 levels resulting in psoriasis. Those with cardiovascular disease and Type 2 diabetes are usually low in F Prausnitzii. Akkermanis Municiphila needs it and vice versa. Prevents inflammation.

It also helps balance the immune system. It needs Akkermansia to thrive. Oligosaccharides increase F. Prausnitzii. It prevents celiac disease. It induces IL-10. It is necessary for fatty acid oxidation. It produces butyrate. It produces Salicyclic acid which is what they make aspirin from. It produces raffinose a type of oligosaccharide that decreases gut permeability which prevents leaky gut. It along with other commensals form biofilms that help protect and heal the gut. Decreases zonulin which preserves the integrity of the tight protein layer. If zonulin levels get too high a person will develop lactose, gluten and gliadin intolerance.

Enterococcus faecium prevents listeria infection and prevents infection from it’s pathogenic cousins. There is a human species which is non pathogenic and an animal species and the animal species is pathogenic to humans. I view this one as a dangerous pathogen even though it is used in probiotics when the body is weak it can make a person very very ill.

Weissella Cibaria also prevents halitosis, cavities, and this one also reduces skin lesions. It also reduces Hydrogen Sulfide and inhibits biofilms. Weisella Cibaria is found in kimchi and fermented milk. It prevents inflammation caused by endotoxins. It also prevent Nirtic oxide induced by endotoxins and promotes the healing of intestinal epithelial cells. It inhibits biofilm formation of pathogenic microbes.

Preovotella Histicola reduces arthritis, increases T regulatory cells and IL-10 which help keep the immune system balanced and reduces TH17. These are often a problem in those with tick born illness or mycoplasma infection. Reduces allergies.

Collinsela Aerofaciens increases intestinal PH which prevents pathogens and keeps candida and H Pylori in their commensal forms. It has been shown to prevent irritable bowel syndrome. It requires maltose, lactose or glucose. Whole grains increase C Aerofaiens. It prevents arthritis by inhibiting IL17.

Lactobacillus Bulgaris increases life span. Helps maintain the proper PH of the bladder and intestines which prevents infection and dysbiosis. Prevents the bladder and intestines from becoming alkaline. If they become alkaline candida and H pylori will go from commensal to pathogenic. It balances the microbiome in the digestive system. It also helps prevent lactose intolerance. It helps prevent liver disease and has been shown to reduce the risk of getting the common cold. It prevents dermatitis and eczema. It has been shown to help with inflammatory bowel disease. It prevents tooth decay and also prevents infection in the intestines and prevents pouchitis. It prevents constipation. It helps neutralize many toxins.

Odoribacter Splanchnicus a loss of Odoribacter causes a loss of SCFA availibility which leads to inflammation and low glucose levels. Deficiency in O Splanchnicus can lead to hypertension and diabetes. Low levels of O Splanchnicus can also lead to interstitial cystitis. It is important for absorption of nutrients and in maintaining a healthy gut. Has been shown to prevent atherosclerosis. Requires glucose, galactose, salicin, trehalose, arabinose, fructose or mannose. Inhibits many of the sulfur digesting bacteria that can cause high sulfite levels and high hydrogen sulfide levels. O Splanchnicus also breaks down phytoestrogens found in many plants.

Lactinifactor Longoviformis breaks down phytoestrogens found in many plants.

Arthrobacter Agilis it produces carotenoids which the body can convert to vitamin A. It reduces the risk of Parkinson’s disease. They degrade many pesticides. It prevents fungus infection but I am not comfortable with Arthobacter species because some of them produce antifreeze and I cannot find any research to show with this one did or not. I do not feel this is a safe probiotic and I have not spoken to anyone who had used it.

Eubacterium Halli it produces butyurate from acetate, glucose and lactate. It produces vitamin B12. It is important for homeostasis in the body and produces SCFA. It improves insulin sensitivity and normalizes blood glucose levels. It cannot process complex carbohydrate and needs bifidobacterium to exist. It makes some carcinogens harmless.

Arthrobacter Globiformis uses sugar as it’s main source of food. It uses sugar and ammonia. It’s byproducts are nitrogen and hydralimine. I do not know the health effects of these but it can break down many toxins in the enviroment but I do not feel comfortable using these as a probiotic I have not seen enough research on the use of this. Their are many of the Arthrobacter species that are used for probiotics and almost all of them break down some form of toxin but I cannot find research on their safety or effectiveness.

Pediococcus acidilactici it has been shown to reduce gastrointestinal distress. It prevents infections by food born pathogens and has been shown to stop bloody diarrhea. It also prevents constipation. Has been show to stop excessive vomiting. It has been shown to fight pathogenic parasites. It increases IL-10 and T regulatory cells which would balance the immune system. It has also been shown to fight fungal infections.

Most Bacillus species convert genotoxic substances to non toxic substances. Bacillus species are found in the soil and in humans. Some can be pathogenic. Man soil based bacteria improve nutrient absorption. There are other strains of Bacillus species but I did not list them because they have the ability to produce endotoxins. Bacillus species help break down food better which improves nutrient absorption. They should be taken with food or they do not get established well. Many of the Bacillus species secrete amylase and lipase. Amylase helps break down carbohydrates and lipase breaks down fats. Bacillus species may help those with malabsorption issues. Bacillus species detox a lot of toxins including mycotoxins found in fungus and molds. Mycotoxins can cause birth defects, sterility, it can increase estrogen levels. Most bacillus species can detox mycotoxins zearalenone, and aflatoxin but other mycotoxins that get broke down are species specific. Most Bacillus species train the immune system on how to fight pathogens. Most bacillus species reduce the risk of diabetes and cardiovascular disease. Most bacillus species help prevent leaky gut and promote healing of the gut.

Bacillus Lacterosporous is found in soil and humans. It fights fungus. Helps prevent leaky gut. It also fights mycoplasma infection. I have not seen studies on the effectiveness or safety of this microbe.

Bacillus Firmis promotes the differentiation of B lymphocytes to Ig producing and secreting cells. It stimulates the repair of blood vessels.

Bacillus Clausii stimulates the production of IgA but requires GALT. Prevents lung infections has been used successfully to treat those who get recurrent respiratory infections. Has also been used successfully to treat acute diarrhea. Studies show it is safe for human consumption. It protects the body from endotoxins.

Bacillus Licheniformis prevents biofilm formation of pathogens. Prevents the build up of amyloid plaque which contributes to amyloidosis and Alzheimer’s. Amyloid can also destroy beta cells leading to diabetes.

Bacteroides Fragilis promotes the production of GALT.

Phages P. Aerugonosa protect against E Faicalis and many food born pathogens.

Bacteroidetes- there are many species. Meat consumption increases their numbers. If bacteroidetes get too high it can result in weight gain or weight loss from malabsorption. It can cause the inability to absorb fats preventing bile production. It can cause the pancreatic enzymes to become inhibitited and cause phenylketonuria which results in high ammonia levels. It can cause BH4 enzyme deficiency, which can lead to CBS upregulation which can lead to high sulfite levels. This can cause the citric acid cycle to shut down leading to high estrogen levels, high unbound copper levels which farther inhibit the bodies ability to produce bile. This farther increases estrogen levels and levels of unbound copper. This lead to inflammatory bowel disease and malabsorption issues. A person with high Bacteroidetes levels will be high in butyrate and proprianic acid, acetate levels may be high also. They will be low in malanic acid. This also leads to high ammonia levels which causes many other health issues and causes Candida and H pylori to go from commensal to pathogenic. Many with this problem will develop bile acid gird. This also makes someone prone to clostridium infection along with many other pathogens.

If this persist long enough a person can develop interstitial cystitis. This is a common problem in those born by C section and who are formula feed. This also leads to a lot of food intolerances especially milk and glutin along with gliaden. This also can result in thiamine deficiency.

Consuming high amounts of meat can result in high bacteroidetes, methane producing bacteria and increased sulfur digesting bacteria. This can result in high levels of sulfite which will interfere with sulfation and cause many health issues. It can also cause high levels of hydrogen sulfide which will lower blood pressure at first then if levels get high enough it will increase blood pressure and cause severe inflammation. Bile production and production of pancreatic enzyme will become inhibited. High sulfite levels makes a person more susceptable to Salmonella infection. This also inhibits bile production. Butyrate ;producing bacteria help restore bile production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023267/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953422/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282957/

Another thing that inhibits bile production is extended use of antibiotics. It reduces our good gut microbiome. Muscrarlis Macrophages detect our good gut microbiomes LPS. With the decrease in our good gut microbiome and loss of their LPS to signal muscarlis macrophages dysbiosis occurs which leads to inhibited intestinal motility which causes a loss of bile production and pancreatic enzyme production. Supplementing with commensal LPS has been shown to reduce the symptoms and increase bile flow.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149228/

https://www.cell.com/abstract/S0092-8674(14)00735-1

https://www.cell.com/cell/pdf/S0092-8674(14)00867-8.pdf

A loss of bile production prevents nutrient absorption, the pancreas will not receive the feedback from our intestines and will quit producing enzymes. This result in malabsorption especially of oil soluble nutrients because bile is need to break down fats. This will also cause LDL levels to get low and HDL levels to because high. This imbalance causes HDL to become inflammatory.

A loss of serrotonin producing gut bacteria negatively impact gut health. Tryptophan helps restore gut health. Strange thing is the first three or four days I took tryptophan I had a herx type reaction. It must have been from die off of the bad gut microbes as the good increased. This can lead to damage to the central nervous system.

http://www.pnas.org/content/115/25/6458

https://www.gastrojournal.org/article/S0016-5085(16)34896-X/abstract

Grape seed extract helps restore bile flow.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817264/

If normal bile function is not restored it effects the whole body and can lead to diabetes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073382/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319718/

https://www.frontiersin.org/articles/10.3389/fmed.2017.00163/full

Good articles on reducing candida when it turns pathogenic.

http://www.gestaltreality.com/2013/09/16/how-to-eliminate-candida-biofilms/

https://www.yeastinfectionadvisor.com/candidadiet.html

https://www.theguthealthprotocol.com/wp/the-alkalizing-myth

https://www.selfhacked.com/blog/treat-cure-candida/

https://www.thecandidadiet.com/candida-fighting-foods/

Sometimes people confuse candida with gut dysbiosis.

http://www.ei-resource.org/illness-information/environmental-illnesses/candida-and-gut-dysbiosis/

http://www.holistichelp.net/blog/candida-sibo-or-h-pylori/

If our ammonia levels get high then H Pylori will turn pathogenic to protect itself. When in commensal form it prevents allergies. When H pylori is in pathogenic form it inhibit ghrelin which inhibits digestion and can cause food to sit in the gut and ferment leading to bloating, dybiosis and can inhibit digestive enzymes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888205/

I am not going to cover histamines in this post I will address it in a post on over and under methylators because high and low histamines can cause over or under methylation. Leaky gut, inflammation and status of our immune system can effect methylation.

Now connect this with my other post and you will see that there is no doubt that germ theory and terrain theory are not correct and that our Facebook groups theory “Enveroment and Biome Theory of Health is correct.

Here is a list of my articles on health that will support my case.

Improtance of human photosynthesis in health.

https://iamajuicer.wordpress.com/2018/11/13/importance-of-human-photosynthesis-in-health/

Why so many are experiencing gender identity crisis.

https://iamajuicer.wordpress.com/2018/11/12/why-so-many-are-experiencing-changes-in-gender-identity-why-so-many-children-have-gender-identity-issues/

We can expect diabetes to rise because of all these things.

https://iamajuicer.wordpress.com/2018/07/21/diabetes-type-1-type-2-and-type-3c/

You can use the above mentioned information to help with hypertension.

https://iamajuicer.wordpress.com/2018/10/28/causes-of-hypertension-and-things-that-may-help/

https://iamajuicer.wordpress.com/2018/10/24/the-truth-about-heart-disease-cholesterol-lowering-drugsand-their-effects-on-mental-health-and-health-of-the-body/

https://iamajuicer.wordpress.com/2018/07/25/carditis-hypertension-tachycardia-and-many-other-cardiovascular-disease-all-have-a-common-tie-and-common-solution/

Compare the above mentioned things and the things that occur within the body and you can make the connection to the gut. This list the many things that can go wrong and how to use nutrients to help heal.

https://iamajuicer.wordpress.com/2018/10/12/my-summarized-notes/

Even allopathic medicine is contributing to the chronic illness and the poor health of modern day society so they are the bad environmental part.

https://iamajuicer.wordpress.com/2018/10/08/cause-of-flaccid-myelitis/

Even our brain gets effected.

https://iamajuicer.wordpress.com/2018/10/02/cant-sleep-feel-disassociated-could-be-your-pineal-gland/

https://iamajuicer.wordpress.com/2018/09/21/things-linked-to-alzheimers-and-chronic-illness/

https://iamajuicer.wordpress.com/2018/07/11/hyper-excitement-of-nmda-autism-also-known-as-encephalitis/

We are taught that things like genetics are inherited but it is our eating habits and microbiome that gets inherited and they are things that can be changed. Even asthma we are taught is inherited but I have seen many in my life correct it and live a normal life and never suffer from it again.

https://iamajuicer.wordpress.com/2018/09/22/causes-of-obesity-and-things-that-may-help/

https://iamajuicer.wordpress.com/2018/09/20/why-asthma-is-rampant-now/

We are told that our genes are written and cannot be changed but science is finding that is not true.

https://iamajuicer.wordpress.com/2018/09/02/1303/

Stomach problems they claim runs in families but it is actually the gut microbiome they inherited and can be corrected.

https://iamajuicer.wordpress.com/2018/09/02/the-microbes-that-help-heal-the-gut/

https://iamajuicer.wordpress.com/2018/08/21/things-that-may-help-those-who-have-the-more-difficult-digestive-problems/

Many have problems with lipid metabolism now days. They claim it is inherited genetics but when I ask people if anyone else in there family suffered from it they say no. So how can it can they inherit something no one else ever experienced in their families?

https://iamajuicer.wordpress.com/2018/08/21/things-that-may-help-with-lysosomals-storage-disease/

The above mentioned things should help with liver disease also.

https://iamajuicer.wordpress.com/2018/08/14/fatty-liver-cirrohsis-thrombosis-and-other-diseases-caused-by-fibrosis/

Many things like COPD are set off by infection or toxins. By now you should know that most supposed pathogens actually help the body unless we have too many toxins or we are lacking a nutrient.

https://iamajuicer.wordpress.com/2018/07/20/things-that-may-help-with-copd/

This is why cancer is so rampant. Cancer is pretty much caused by man and the environment men have created.

https://iamajuicer.wordpress.com/2018/07/29/cancer-what-causes-it-what-may-help-with-it/

https://iamajuicer.wordpress.com/2018/07/22/what-they-dont-want-you-to-know-about-cancer-and-why-so-many-children-are-getting-it/

Our enviroment and biome can effect our health by causing excess oxidative stress.

https://iamajuicer.wordpress.com/2018/08/02/oxidative-stress-the-antioxidant-systems-and-how-they-effect-our-health/

Now you can see why tick born illness is rampant. Thing that usually would not usually effect man is now causing illness. Infection indicates there is a nutrient deficiency or enviromental toxin or enviromental biome issue. Something is out of balance. Man is viewing symptoms like cancer, diabetes, and mental illness as the cause and they are symptoms of underlying problem.

https://iamajuicer.wordpress.com/2018/06/17/vaccinations-spread-and-cause-disease/

https://iamajuicer.wordpress.com/2018/10/08/cause-of-flaccid-myelitis/

https://iamajuicer.wordpress.com/2018/07/21/things-they-would-rather-you-did-not-know-about-lyme/

Vaccination are one of the biggest contributors of modern illness.

https://iamajuicer.wordpress.com/2018/07/13/identifying-vaccine-injury-and-its-cost-to-society/

This is why detoxing is so important now days. Even our food has become toxic. Organic helps reduce the impact of mans destruction of our environment and the human and planetary biome.

https://iamajuicer.wordpress.com/2018/07/14/detoxing-we-need-it-now-days/

https://iamajuicer.wordpress.com/2018/07/23/how-toxic-is-your-food/

https://iamajuicer.wordpress.com/2018/06/17/genetically-modified-foods-destroy-our-health-glyphaste-and-glufonisate-add-to-the-toxicity/

They know their science is fake so they use every tactic they can to hide that fact.

https://iamajuicer.wordpress.com/2018/08/11/tactics-used-by-corporate-science-to-deceive-people-into-no-asking-questions/

If you have read this then by now it have figured out it is not your genes but your enviroment, inner and outer biome and not your genes that effect your health.

https://iamajuicer.wordpress.com/2018/06/27/its-not-your-genes-it-is-your-gut-microbiome/

Histamine homeostasis is very important in fighting chronic illness.

https://iamajuicer.wordpress.com/2018/07/12/the-effect-of-high-or-low-histamines/

Since modern day illness is causing chronic illness by destroying our gut we need to work on restoring it to heal. Leaky gut causes endotoxemia. I listed in the microbe list above which ones reduce endotoxins. It also causes high oxalates so you will have to work on reducing them.

https://iamajuicer.wordpress.com/2018/06/28/leaky-gut-oxalates-and-more-supplement-information/

https://iamajuicer.wordpress.com/2018/07/08/dealing-with-endotoxemia-or-sepsis/

All these things are types of autoimmunity and we need to restore our immune system back to homeostasis.

https://iamajuicer.wordpress.com/2018/07/15/autoimmunity-what-causes-it-and-things-that-may-correct-it/

Interstitial cystitis and vaginitis are some of the worst autoimmune disorders to deal with because our modern day environment makes it difficult to acheive homeostasis in the areas effected.

https://iamajuicer.wordpress.com/2018/07/15/causes-of-vaginitis-thinning-or-atrophy-of-the-vaginal-walls-and-things-that-may-help/

https://iamajuicer.wordpress.com/2018/06/18/healing-interstitial-cystitis/

 

Constipation can lead to inflammatory bowel disease and inhibited bile productin and  is caused by an imbalance in our gut microbiome. It can lead to chronic illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951383/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872693/

I noticed that those with dysbiosis had issues when the consumed or took tryptophan. This study suggest that SERT might be upregulated in dysbiosis which wold explain why tryptophan made them worse. Sert is the serotonin transporter.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583244/

https://www.nature.com/articles/s41598-017-10835-8

There are those who say but things like H Pylori cause illness. So how could that prove what your are saying. H Pylori just like many of our beneficial bacteria only cause problems when something has changed to cause it to occur. They say yeah but there is strains that are pathogenic and strains that are not. Well the biggest part of the population is believe to have the supposed pathogenic strain of H Pylori. So you have to ask why doesn’t everyone get gastric ulcers?

https://www.frontiersin.org/…/10…/fmicb.2018.00609/full

Even our good gut bacteria can cause illness if we have digestive problems.

https://www.sciencedirect.com/science/article/pii/S1198743X14618838

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490230/

Our food and water is so toxic now it has a negative impact on our guts. The crazy thing is some of these toxins are found in vaccines so imagine what they are doing when they are being directly shot into peoples blood streams.

https://www.mdpi.com/2076-2607/6/2/53/htm

Desulfibrio species digest sulfur which produces H2S. If H2S levels get too high it can cause many health issues. B Thetamiomicron free sulfur which feeds Desulfibrio species. They cannot free it themselves. Mercury and lead increase Desulfibrio species. Excess H2S can lead to constipation. This is why high levels of Akkermansia and Desulfibrio results in inflammatory bowel diseases, gall stones and many other diesease. Not getting enough fermentable carbohydrates increases sulfur digesting microbes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1233901/

https://www.ncbi.nlm.nih.gov/pubmed/26491870

https://www.ncbi.nlm.nih.gov/pubmed/19709217

https://www.tandfonline.com/doi/abs/10.3109/00016357.2013.770163

https://www.frontiersin.org/articles/10.3389/fmed.2017.00163/full

It is listed among the bacteria that increases the risk of heart disease and diabetes.

https://www.ncbi.nlm.nih.gov/pubmed/29800124

Glycomacropeptide found in whey protein and fermentable fiber reduces sulfur digesting bacteria. Fermentable fibers are pectin, Beta-glucan found in mushrooms and oatmeal, guar gum, inulin and oligosaccharides. If a person is not used to getting them they will have to ease into them. Until the body is used to getting them they will cause bloating and gas. As the body gets used to them the symptoms will slowly decrease. Psyllium should be avoided it has been found to make the symptoms worse.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593820/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190755/

Those with inflammatory bowel and gut dysbiosis usually have high levels of H2S being produced by their gut microbes. Fructooligosaccharide and Resistant starch decreases H2S but psyllium increases it so psyllium should be avoided.

https://www.ncbi.nlm.nih.gov/pubmed/29561196?fbclid=IwAR3wOZijtOeO0NF_4liAPIZwHwiK-bAqMn4IsPFQNQ1PbkuJU0cydwzuFs0

Strange lactulose is in raw milk increases Hydrogen production but it helped me.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201941/

Now we do not want to completely rid ourselves of the H2S producing microbes because they are needed to keep us health. We want to try and restore homeostasis. For those with high sulfur digesting bacteria a glass of non sulfur wine may help.

https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.855.3

High H2S levels can effect sulfation by inhibiting sulfur detoxification. It can even effect the antioxidant system. High H2S levels also inhibits nNOS. It can be countered by increasing NADPH and BH4.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040266/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210431/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599001/

Methane producing bacteria can also cause constipation leading to inflammatory bowel diseases. Those with high methane levels usually suffer from nausea, will feel full and bloated, may experiencing vomiting. They will have milk intolerance because the sugars in milk feed methane producing bacteria. They will experience bouts of severe depression. Constipation causes bile to become inhibited resulting in similar health problems as those who have high sulfur digesting bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987281/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544731/

For those with dysbiosis from high methane producing bacteria should not drink alcohol it can make it worse.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544731/

Those with methane producing dysbiosis need to avoid fermentable carbohydrates and lactulose found in milk products. I know those feed the good gut bacteria but they also feed the gut bacteria that produce hydrogen which feeds the methane producing bacteria.

https://bellalindemann.com/treat-constipation-causing-methane-sibo/

Methane producing bacteria out compete Sulfur digesting bacteria for H2 unless sulfate is present.

https://gut.bmj.com/content/32/12/1498

This surprised me the same microbes that feed the sulfur digesting bacteria also feed the methane producing bacteria. Firmicutes and bacteroides is high in both types of dysbiois.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC442992/

This is another commonality that I have found with those who have inflammatory bowel from too many sulfur digesting and too many methane producing is they both had low bacteroides fragilis levels. I am cautious recommending this because if level get too high it can cause health problems.

https://www.hindawi.com/journals/bmri/2016/5828959/

Bacteroides vulgatis and Bacteroides Dorei are usually low in both types of inflammatory bowel and can lead to cardiovascular disease. Seems there is an easy fix for this. Eating walnuts. This should help Both types of inflammatory bowel issues.

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.033714

https://www.fasebj.org/doi/abs/10.1096/fasebj.29.1_supplement.1006.1

Excessive methane production or excessive hydrogen production can cause malabsorption. So both should be measured in those with malabsorption issues.

http://iopscience.iop.org/article/10.1088/1752-7155/7/2/024001/meta

Alcohol consumption should be avoided with methane producers because it increases methane.

https://www.nature.com/articles/s41598-017-07637-3

The gut microbes are dramatically different in those with NAFLD.

When you look at studies on cirrhosis of the liver. The things that help NAFLD seem to be things that improve oxidation which leads me to believe they are low oxidizers. But alcohol liver disease seems more inflammatory. But they both have links to the gut. Very interesting report.

https://www.mdpi.com/2072-6643/10/10/1457

If a person craves sugar it may mean their lactobacillus acidophilus levels are too high.

Microbes interact with our mitochondria including our gut microbes.

https://academic.oup.com/femspd/article-pdf/74/1/ftv096/10749982/ftv096.pdf

Chemicals in our environment and those pushed by the pharmaceutical industry change our external environment which is killing the commencile pathogens that keep the pathogenic ones in check. This is a common theme now days. When someone gets and infection they either have high toxin levels, were taking allopathic medications or had a nutrient deficiency. All those effect our commensals that protect us from their pathogenic cousins.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510460/

Some functional food that help straighten the gut out.

https://www.frontiersin.org/articles/10.3389/fmicb.2017.02146/full

https://www.frontiersin.org/articles/10.3389/fvets.2018.00166/full

 

Probiotics and their effects on autoimmune disease.

https://www.mdpi.com/2072-6643/10/10/1537/htm

And yes autoimmunity can lead to mental illness that is why vaccine damage the brain.

https://onlinelibrary.wiley.com/doi/full/10.1111/imm.12943

Using the information on probiotics above you can see the connection between the gut and arthritis.

https://www.mdpi.com/1422-0067/19/9/2508

Those with Trimethylaminuria may be deficient in sulfur digesting bacteria. This would reduce TMAO in the plasma. Could Trimethylaminuria be from a deficiency in methane producing and enterobacteriaceae?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239492/

https://www.nature.com/articles/ismej201772

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0461-0

How microbes effect neurological stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736941/

This report shows why it is important to address leaky gut and gut dysbiosis. It can damage the kidneys.

https://www.mdpi.com/2072-6651/10/7/300

Methylation issues must be addressed before you can get your gut to heal.

Overmethylators

http://www.mensahmedical.com/common-symptoms-of-overmethylation/

Undermethylators.

http://www.mensahmedical.com/common-symptoms-of-undermethylation/

IL-22 is needed to protect us from pathogens and to stimulate FUT2. If we are deficient in certain gut microbiota that stimulate FUT2. We will have immune issues and gut dysbiosis because FUT2 keeps our good gut microbes health.

http://www.traceyreed.ca/blog/2016/4/12/fut2s-role-in-gut-healths-role-in-gut-health

https://www.sciencedirect.com/science/article/pii/S0022283615006051

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774895/

ILC3 is needed for our gut microbiome to communicate with the body to increase FUT2. ILC3 is secreted by our gut microbiome.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774895/

http://science.sciencemag.org/content/345/6202/1254009.long

https://www.researchgate.net/publication/260808789_Microbiota-Dependent_Crosstalk_Between_Macrophages_and_ILC3_Promotes_Intestinal_Homeostasis/download

Oligosaccharide helps if someone is deficient in FUT2

https://nutritionfacts.org/2013/01/10/boosting-gut-flora-without-probiotics/

https://www.newhope.com/ingredients/oligosaccharides-revealing-more-health-benefits

If the immune system is out of balance IL-22 can be upregulated causing illness. This is why the microbiome that increase T regulatory cell and decrease inflammation are important and reducing endotoxins is also important.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710696/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117408/

https://www.dovepress.com/profile-of-interleukin-22-in-gut-mucosal-health-and-disease-peer-reviewed-fulltext-article-IJICMR

https://www.sciencedirect.com/science/article/pii/S0925443914001513

IBS with constipations is IBS-C, IBS with diarrhea is IBS-D, IBS that is mixed is IBS-M. Most I have met have IBS-C and it is why I post on constipation a lot.

5-HT(serotonin) helps regulate gut motility.

https://www.ncbi.nlm.nih.gov/pubmed/25954931

Lactobacillus Rhamnosus GG increases 5-HT uptake .This would help those who have diarrhea but will decrease motility adding to the problem for those who have constipation type inflammatory bowel. 5-HT plasma levels in those who have diarrhea is low and in those who have consipation it is high. E Coli Nissle 1917 increases 5-HT bioavailibility. F Prausnitzi A2-165 down regualates 5-HT which may help those with constipation type inflammatory bowel. Some of the studies were done poorly but there is useful information in them. They also list some microbiota that can improve motility.

https://www.wjgnet.com/1007-9327/full/v24/i3/338.htm

https://www.wjgnet.com/1007-9327/full/v22/i36/8137.htm

https://www.ncbi.nlm.nih.gov/pubmed/28871143

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583244/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951383/

There are three forms of IBS. IBS-D involves diarrhea, IBD-C involves constipation and IBD-M is a mix of both. Serotonin regulates gut motility and enzyme secretion. Damage to the digestive system and leaky Gut effects GLP-1’s ability to sense nutrients. 5-HT is involved in the regulation of gut motility and enzymes. It depends on GLP-1 and serotonin. Gut our gut bacteria regulate serotonin and GLP-1. The type of microbes involved in the dysbiosis determines which type of IBS a person will suffer from.

https://www.sciencedirect.com/science/article/pii/S2212877818301406

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263172/

Healing the brain and addressing high zonulin levels and restoring the gut bacteria and addressing neurological issues are necessary to restore proper gut brain communication. Inflammation must also be addressed.

https://www.frontiersin.org/articles/10.3389/fnins.2018.00049/full

http://www.mdpi.com/1424-8247/11/3/63/pdf

How metabolic issues disrupt the communication with our gut.

http://jem.rupress.org/content/213/10/2129

Our genes communicate with our gut bacteria.

http://jem.rupress.org/content/215/8/1965.long

http://cancerres.aacrjournals.org/content/77/8/1783

Our genes can be altered by our environment and what we put in them.

https://iamajuicer.wordpress.com/2018/09/02/1303/

A good article on the immune system and our gut.

https://www.karger.com/Article/FullText/484687

 

 

Importance of human photosynthesis in health.

This is not medical advice I am posting this for informational and educational purposes.

 

In order for melanin to produce energy carboxylation is necessary. If the citric acid cycle is not functioning then carboxylation will be inhibited and so will melanins ability to produce energy.

Melanin is photoelectric.

http://precedings.nature.com/documents/1312/version/1/files/npre20071312-1.pdf?q=photoelectrochemical

Human photosynthesis helps prevent alhzheimer’s.

https://www.omicsonline.org/human-photosynthesis-and-alzheimers-disease-2153-2435.S15-005.php?aid=5999&fbclid=IwAR0HSVkqksZNnkWTKmZup30NUvsAt7UjKzRLTfZktY3D6kDkbYqpfqn-OzQ

Human photosynthesis helps prevent chronic disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125832/?fbclid=IwAR03HBikeH3AhiFVyCsDCl84p8o5IfDeTZfZcBDXVAto-I_jX9j14FXdXP0

Human photosynthesis produces ATP.

https://www.ncbi.nlm.nih.gov/pubmed/24198392?fbclid=IwAR0sdC80wTDj5AicZaGC5bA73VSX803SSEwgkxTKs1aRuQaxnMiiULse1yg

https://www.ncbi.nlm.nih.gov/pubmed/25645910

Difference between plant and human photosynthesis.

http://www.scienpress.com/Upload/JAMS/Vol%202_2_2.pdf

Humans can also capture energy from chlorophyll and is probably the reason we have more energy after we eat greens.

http://jcs.biologists.org/content/127/2/388.long

https://www.ncbi.nlm.nih.gov/pubmed/18479839

Melanin protects us from ionizing radiation by converting it to electricity. What a shocking discovery, sorry lol I couldn’t resist.

https://www.ncbi.nlm.nih.gov/pubmed/21632287

https://www.ncbi.nlm.nih.gov/pubmed/22968190

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1866175/

Repairing cavities and preventing oral bone loss.

This is not medical advice I am posting this for informational and educational purposes.

 

teeth

To have success in preventing loss of teeth you need to address infections and health issues. I did this to prevent any more loss of teeth and farther bone loss but my bone did not grow back until I had addressed my Lyme disease and the health issues it caused. Something that provides minerals needed is water from a volcanic source or hot spring.

I have watched friends repair cavities by remineralizing them with proper nutritional support and coconut oil flushing. They used straight coconut oil but I have Lyme and it was also causing bone loss so I modified things a bit to help fight the infection and stop the bone loss the Lyme was causing. I got angry because for 5 years dentist would not help me because they said it was not gingivitis so they did not know what to do. When I would go to a doctor they would tell me it was a dental problem and they could not help me. I wish my Facebook friends would have taught me this sooner because I started pulling my teeth and pulled three of them before they posted this. It did save the rest of my teeth though. Because diets do not contain enough healthy animal fats now days to be able to absorb oil soluble vitamins and glyphosate and over farming cause our food to be less nutritious our health and the health of our teeth are declining.

I did not measure I just dumped the stuff in I do that when I cook so I cannot give you the right amounts I would say to do some research. I will estimate the amounts.

In 10 ounces of coconut oil put about 1/8 teaspoon of powdered vitamin C.

Add about a table spoon of cinnamon and a table spoon of curcumin.

Add about a tablespoon of xylitol to the coconut oil.

Mixed it around and let it set for about a week. If you prefer you can use warm water to melt it to make it mix better. Then after letting it set you can repeat the process by setting the container in warm water and then use a filter to filter the coconut oil.

Then take a huge heaping tablespoon full and swish it around in your mouth for at least 15 minutes before bed at night. When finished gargle with it then spit it out but do not rinse go to bed and you will wake up and be pleasantly surprised you will not have the morning gunk that many get even when they brush before bed.

The vitamin C and xylitol helps prevent and fight infection.

As for diet try to avoid processed sugar especially processed can sugar and processed fructose.

Here is are links with great information on nutrient needed for healthy teeth.

https://www.westonaprice.org/health-topics/abcs-of-nutrition/beyond-good-and-evil/?fbclid=IwAR3lA22xzzYkWhgR31qA-m0xyKF0xCVpZBk1Atr6wUZPWbUxq9i77vhmkGU

Read the comments on this link very interesting.

https://wholehealthsource.blogspot.com/2009/03/preventing-tooth-decay.html

Lyme may get into the dentin in teeth so this will have to continue for quite a while.

https://academic.oup.com/femsle/article/362/15/fnv120/550276

http://www.stopthelymelies.com/stll-blog/lyme-disease-in-the-mouth-good-oral-hygiene

Do not use fluoride or drink fluorinated water. Fluoride makes the teeth brittle.

https://fluoridealert.org/issues/fluorosis/

https://www.ncbi.nlm.nih.gov/pubmed/10086925

Brushing your teeth with toothpaste that contains hydroxyapetite also helps remineralize the teeth.

https://www.sciencedirect.com/science/article/pii/S0300571211000832

If you smoke stop , smoking has been shown to cause gingivitis.

If you have digestive issues they must be addressed.

https://www.drstevenlin.com/how-your-gut-microbiome-link-to-a-healthy-mouth/

Bacteria like lactobacillus, streptoccocus salvarius, streptoccocus mitis, Prevent infection in the mouth nose and through and also help prevent cavities and dental plaque. E Coli Nisle 1977 prevents infection in the mouth and helps prevent halitosis.

http://www.rroij.com/open-access/a-review-on-the-human-oral-microflora-.php?aid=78710

Lactobacillus Plantarum prevents biofilm formation in the mouth.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805336/

Lactobacillus plantarum prevents oral biofilms, Bifidobacterium and Lactobaccilus Rhamnosus helped prevent cavities. Lactobacillus Salvarius helps prevent dental plaque.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432076/

Lactobacillus Reuteri reduces dental plaque, prevents periodontal disease and reduces inflammation. Bifidobacterium Animalis prevents bone loss and gingivitis. Bacillus Subtilis, Bacillus Licheniformis and Lactobaccilus Brevis also prevent bone loss. L Brevis CD2 reduces inflammation and prevents gingivitis. Lactobacillus Rhamnosus, Lactobacillus Casei Shirota, Lactobacillus Reuteri and Bifidobacterium prevents cavities. Streptococcus Dentisani and Streptococcus Salivaries M18 produce bacteriocins which kill harmful microbes they prevent gingivitis and infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688201/

Lactobacillus Planatarum, Lactobacillus Paracasei, Lactobacillus Salivarius, and Lactobacillus Rhamnosus have antimicrobial properties. Lactobacillus Salivarius and Lactobacillus Gasseri prevent halitosis and prevent opportunistic infections. Weissella Cibaria also prevents halitosis this one also reduces skin lesions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415334/

Streptococcus Thermophilus is a subspecies of Streptococcus Salivarius and has many of the health benefits of Salivarius and also helps with metabolic issues. The commensal Streptococcus strains of microbiota help prevent strept throat.

Though many of these strains can probably be purchased in probiotics I am not going to research that. That is up to the reader.

Streptococcus Salivarius K12 prevents ear infections, inflammation and cavities. This and other beneficial Streptococcus Salivarius strains are used in some yogurts and cheeses so they could be a source of these strains.

Streptococcus Thermophilus is used in low fat cheese so that could be a source of it.

Lactobacillus Plantarum is found in fermented foods and aged meats.

Lactobacillus Paracasei , Lactobacillus Rhamnosus,Lactobacillus Gasseri is found in fermented foods like fermented vegetables or fermented milk products.

Weissella Cibaria is found in Kimchi, and raw milk.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362408/

Lactobacillus Reuteri would be found in sour dough but would not survive the cooking process so would have to be purchased in a probiotic.

Bifidobacterium Animalis is found in raw milk and fermented milk products.

Bacillus Subtilis and Bacillus Licheniformis is found in the soil and soil based probiotics.

Lactobaccilus Brevis is found in fermented foods like sauerkraut and fermented pickles.

Lactobacillus Casei Shirota normally has to be purchased and is used to ferment some beverages.

As for the Bifidobacterium I believe the only source I could find was raw milk and probiotics.

Now for bone loss using soup bones and cooking them for 24 hours and consuming the broth will give the nutrient needed for the body to restore lost bone.

https://www.thehealthyhomeeconomist.com/periodontal-problems-bone-broth-key-to-your-recovery/

Silica is needed for new bone growth.

https://www.betterbones.com/bone-nutrition/silica/

How modern medicine got corrupted and is now based on fake science.

I have seen doctors push medications even when there was nothing wrong with someone. I have seen them prescribe medication even when they knew the person was having an adverse reaction to the drug they would just prescribe them another drug to try and hide the adverse reaction to the first and so on and so on. A person ends up taking ten different prescriptions at a time. It made me ask why do they push medications so much? I found the answers they make a lot of money from the pharmaceutical industry and the more money they make the pharmaceutical industry the more money the pharmaceutical industries pays them and the more gifts they give them. Just one free meal has been shown to sway a physician. By the time a student has graduated they have become conditioned to respond positively to the pharmaceutical industry and blindly listen to them without questioning their motives or truthfulness.

https://jamanetwork.com/journals/jama/fullarticle/2623606?resultClick=1

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2528290

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623540/

This is nothing new the tobacco industry paid medical professionals to promote their products as safe and even as being beneficial.

https://www.industrydocumentslibrary.ucsf.edu/tobacco/docs/#id=kynp0183

Even today this still goes on and the pharmaceutical industry pays people to ghost write. So modern day pharmaceutical research is just another version of tobacco science. Vioxx is and example of this happening and just as the ill effects of tobacco were hidden so were the ill effects of Vioxx.

https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1000335

https://jamanetwork.com/journals/jama/article-abstract/181773

We cannot count on our politicians to protect us because most of them have been bought by the pharmaceutical industry.

https://www.opensecrets.org/lobby/induscode.php?id=H4300&year=2016

https://www.publicintegrity.org/2005/07/07/5786/drug-lobby-second-none

Major amounts of money is spent to influence medical professionals decision making to favor the pharmaceutical industry.

https://www.propublica.org/article/our-first-dive-into-the-new-open-payments-system

The pharmaceutical companies start grooming medical professionals while they are still in school. It has been shown to influence their practice and prescribing habits.

https://www.ncbi.nlm.nih.gov/pubmed/21629685

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778453/

https://journals.lww.com/academicmedicine/Fulltext/2004/11000/Medical_Students__Exposure_to_Pharmaceutical.5.aspx

https://www.researchgate.net/profile/Marta_Makowska/publication/321873999_Pharma’s_Marketing_Influence_on_Medical_Students_and_the_Need_for_Culturally_Competent_and_Stricter_Policy_and_Educational_Curriculum_in_Medical_Schools_A_Comparative_Analysis_of_Social_Scientific_Res/links/5a381a720f7e9b7c486f7b7d/Pharmas-Marketing-Influence-on-Medical-Students-and-the-Need-for-Culturally-Competent-and-Stricter-Policy-and-Educational-Curriculum-in-Medical-Schools-A-Comparative-Analysis-of-Social-Scientific-Rese.pdf

You can research how much the drug companies kickback to doctors and medical institutions at these links.

https://openpaymentsdata.cms.gov/

https://projects.propublica.org/docdollars/

https://journalofethics.ama-assn.org/article/mixing-dinner-and-drugs-it-ethically-contraindicated/2015-08

The pharmaceutical companies paid to have opioid promoted and caused the opioid epidemic. They have a lot of blood on their hands.

https://ajph.aphapublications.org/doi/10.2105/AJPH.2017.303982

Studies have shown that how much money and gifts are kicked back to medical institutions and doctors influence how often they prescribe certain medications. The more the kick backs the more likely they were to prescribe them.

https://www.ncbi.nlm.nih.gov/pubmed/27540015

https://www.ncbi.nlm.nih.gov/pubmed/29069085

After studies like this one they passed laws to try to prevent it from occurring but the pharmaceutical industry have found ways around it.

https://www.mja.com.au/journal/2002/176/3/ethical-issues-concerning-relationships-between-medical-practitioners-and

Even the educational institutions medical institutions have not adequately addressed the conflicts of interest.

https://www.egms.de/static/en/journals/zma/2017-34/zma001114.shtml

http://med.stanford.edu/coi/journal%20articles/Wazana_A-Is_A_Gift_Ever_Just_A_Gift.pdf

https://bmjopen.bmj.com/content/7/9/e016408.long

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174934

It is unlikely much will be done about it or the laws will be enforced because many of our politicians are funded by the pharmaceutical industry. It is destroying the reliability and credibility of moder medicine.

https://www.theguardian.com/us-news/2017/oct/19/big-pharma-money-lobbying-us-opioid-crisis

https://bmcmededuc.biomedcentral.com/articles/10.1186/1472-6920-5-5

Doctors are not trained to see the missing data or bias in pharmaceutical research so they take it at it’s word even though often times it has been found to be flawed.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883830/

This is a website that follows the pharmaceutical money trail to politicians , medical institutions, educational institutions and medical professionals.

https://www.propublica.org/article/double-dip-doctors-paid-to-advise-promote-drug-companies-that-fund-research

Unlike most research that has been proven flawed pharmaceutical research that has been proven flawed does not get restracted.

https://www.cbsnews.com/news/ghostwritten-drug-studies-have-a-healthy-afterlife-in-academic-archives/

Much of the medical research is flawed and the truth of the results hidden. They influence the scientist to embellish the results to put things in a favorable light.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5914207/

https://www.bmj.com/content/341/bmj.c6985

Research replication is supposed to be a way of testing the validity of the results but most research cannot be replicated. Yet the research is published and accepted by the medical community.

http://science.sciencemag.org/content/349/6251/aac4716

https://www.nature.com/articles/483531a#t1

The Truth About Heart Disease, Cholesterol Lowering Drugs,and their effects on mental health and health of the body.

 

This is not medical advice I am posting this for informational and educational purposes.

There are many myths about cholesterol that is propagated by the pharmaceutical industry to boost their profits and by the medical community out of ignorance. They are taught to believe things that are not scientifically or factually true about fat and cholesterol. In feeding the pharmaceutical greed machine they are causing a lot of suffering and will be held accountable by God. These links show the truth about heart disease, cholesterol and fats. At the end of this I listed things that may help with heart disease. The beginning shows the truth about cholesterol and the rest discusses how statins actually contributed to increased mortality and declining health especially mental health.

Symptoms of low cholesterol.

https://www.healthline.com/health/cholesterol-can-it-be-too-low?fbclid=IwAR0Dv_NbRoeDnzYxOlGw3ZwqLEsResBiXrpAaceoCQeMn2tNakqxasC7cwo#low-cholesterol

http://www.greenmedinfo.com/blog/underreported-dangers-low-cholesterol?fbclid=IwAR2slcmIPqyfwK-GbHsXLy-LmYVFP8K0CSpbqtmwk7NxJNw-dN0_9G2_PwQ

Low cholesterol can increase risk of death.

https://www.nature.com/articles/srep41650?fbclid=IwAR3B21b-ggJgExy-n5zwRCBC6bWBhn_qpfQBKeoyDqpHpxxj8slBQZluih8#abstract

The believed HDL was good cholesterol and LDL was bad but they are finding you need a balance of the two. If HDL levels get too high it can cause inflammation. Inflammation lead to heart disease.

https://people.healthsciences.ucla.edu/institution/publication-download?publication_id=249207&fbclid=IwAR2MCJyFtPHzcVwQcxUBLHuAEyIiLnVrp2VT_80vHngzbe7gxXYnZL1jOz0

https://www.hindawi.com/journals/cholesterol/2011/274629/?fbclid=IwAR0d2QvZVABZIvzGZMnyypcrQmobOdd84HsfknSyb3U8tLQ0hCnASOKhDKo

I posted links to information on how to lower cholesterol at the end of this post. For now lets address the myths surrounding cholesterol.

http://www.ravnskov.nu/cholesterol/

https://www.docmuscles.com/the-ketogenic-cholesterol-quandry/

http://www.13.waisays.com/cholesterol.htm

There was a man who ate 25 eggs a day all his life and was very healthy.

https://www.nejm.org/doi/full/10.1056/NEJM199103283241306

There are many benefits to cholesterol in the diet.

https://www.thehealthyhomeeconomist.com/the-9-benefits-of-cholesterol-in-the-diet/

Worlds most renown heart specialist speak out about the true cause of heart disease.

https://www.healthy-holistic-living.com/heart-surgeon-speaks-true-cause-heart-disease.html?utm_source=DM&utm_content=49524-4FRO

Cholesterol protects us from infections.

https://academic.oup.com/qjmed/article/96/12/927/1533176

https://www.ncbi.nlm.nih.gov/pubmed/28718976?fbclid=IwAR0JVMe58PCg3iZredsoqtxywegXgmpPemLI9QejkW_wopp6Q7BNCp2EqYo

There is no link between high cholesterol and heart disease.

https://bmjopen.bmj.com/content/6/6/e010401

https://jamanetwork.com/journals/jama/article-abstract/381733?redirect=true

Low cholesterol levels have been linked to higher mortality rates.

https://www.karger.com/Article/Fulltext/355164

http://www.drbriffa.com/2014/01/31/statins-associated-with-increased-risk-of-death-in-those-with-heart-failure/

High cholesterol is linked to lower mortality.

https://bmjopen.bmj.com/content/6/6/e010401

https://www.naturalnews.com/033975_high_cholesterol_heart_attacks.html?fbclid=IwAR0ScVaUKVXOD84N1-8i7CfS9dvTWQGHoxcsJYwLXy6GvCAyZ4qaSnhdDXk

Simple reasoning should have people thinking fat and cholesterol have been dramatically reduce in the diet in the U.S. , yet obesity and heart disease has climbed dramatically.

https://chriskresser.com/why-you-should-eat-more-not-less-cholesterol/

https://drmalcolmkendrick.org/2015/12/21/cholesterol-goes-up-heart-disease-goes-down/

https://www.news-medical.net/news/20160627/Older-adults-with-high-LDL-C-live-longer-than-peers-with-low-levels-of-same-cholesterol-say-experts.aspx

https://www.tandfonline.com/doi/full/10.3109/02813432.2013.824157

Here is another good website with links to information on cholesterol.

http://www.thincs.org/

For those who like watching videos here is a video on cholesterol and heart health.

https://www.ihealthtube.com/video/will-forever-change-how-you-view-cholesterol-and-heart-health

Here is another video with the best advice I have seen on lowering blood pressure.

https://www.youtube.com/watch?v=GizDuANT9BE

A high egg diet does not cause a higher risk of cardiovascular disease.

https://academic.oup.com/ajcn/article/101/4/705/4564505

https://www.mdpi.com/2072-6643/7/9/5344/htm

https://www.tandfonline.com/doi/abs/10.1080/07315724.2004.10719429#.UvNz1bT1adA

Eating eggs improves our good cholesterol levels and does not increase the oxLDL or increased it very little.

https://www.ncbi.nlm.nih.gov/pubmed/23021013

https://www.ncbi.nlm.nih.gov/pubmed/8120521

https://academic.oup.com/jn/article/138/2/272/4664988

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904713/

https://www.ncbi.nlm.nih.gov/pubmed/15721501

https://academic.oup.com/ajcn/article-abstract/32/5/1051/4666331?redirectedFrom=fulltext

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(84)92168-8/fulltext

https://www.ncbi.nlm.nih.gov/pubmed/19369056

https://www.ncbi.nlm.nih.gov/pubmed/23021013

Even if eggs raise LDL levels those with high LDL levels have a lower risk of heart disease and diabetes.

https://www.ahajournals.org/doi/abs/10.1161/01.atv.12.2.187

https://www.ncbi.nlm.nih.gov/pubmed/23021013

https://jamanetwork.com/journals/jama/article-abstract/374290

https://www.ahajournals.org/doi/abs/10.1161/01.cir.95.1.69

Observational studies have shown that eating eggs does not increase cholesterol and in some instances it improved lipid profiles.

https://www.bmj.com/content/346/bmj.e8539

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1467-3010.2006.00543.x

https://www.ncbi.nlm.nih.gov/pubmed/11111098

https://www.ncbi.nlm.nih.gov/pubmed/21134328

https://www.ncbi.nlm.nih.gov/pubmed/24079288

Cholesterol protects us from inflammation.

https://www.sciencedaily.com/releases/2013/12/131209105240.htm

Eggs actually improve our antioxidant satus especially if the chickens are fed a diet high in antioxidants. Free range chickens eat a lot of antioxidant rich foods.

https://pubs.rsc.org/en/Content/ArticleLanding/2013/FO/C2FO30154G#!divAbstract

http://nutrition.highwire.org/content/134/8/1887.short

https://academic.oup.com/ajcn/article/70/2/247/4431045

Not all eggs are the same there is a nutritional difference between free range and caged chicken eggs. Free range have more nutrients.

https://www.healthline.com/nutrition/pastured-vs-omega-3-vs-conventional-eggs#section2

https://www.sciencedirect.com/science/article/pii/S0308814609003513

https://www.cambridge.org/core/journals/renewable-agriculture-and-food-systems/article/vitamins-a-e-and-fatty-acid-composition-of-the-eggs-of-caged-hens-and-pastured-hens/552BA04E5A9E3CD7E49E405B339ECA32

Processed sugar causes hardening of the arteries. The sugar industry started the myth about cholesterol and fat to hide the fact hey were causing the heart disease.

https://www.npr.org/sections/thetwo-way/2016/09/13/493739074/50-years-ago-sugar-industry-quietly-paid-scientists-to-point-blame-at-fat?fbclid=IwAR3jWbauFpAAGCXuYCOdd9d7R-Tq5hQuEtUYv94v61xL9g0TJNxGI1Oyq6U?fbclid=IwAR3jWbauFpAAGCXuYCOdd9d7R-Tq5hQuEtUYv94v61xL9g0TJNxGI1Oyq6U

https://www.sciencedirect.com/science/article/pii/S0002870316300230

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490579/

Issues with bile production which can be caused by gut dysbiosis, vaccine injury, farm chemicals found in our food, heavy metals and many other things can lead to gallbladder problems. That can lead to cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678091/

We need fat to protects us from developing diabetes.

http://www.diabetes-book.com/truth-fats-iv/

They make starch out to be a villain and claim it leads to obesity and heart disease but that is not true.

https://www.thehealthyhomeeconomist.com/best-resistant-starch-for-gut-health/

They paint sugar as a villain even the sugar in fruits sugar in fruit prevents heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745665/

Vitamins C prevents heart disease but if taken in mega doses it destroys red blood cells and causes cardiovascular disease.

http://altmedangel.com/vitamin-Cdangers.htm

Low cholesterol causes depression, suicidal thoughts and aggressiveness.

https://www.ncbi.nlm.nih.gov/pubmed/19263395?fbclid=IwAR3p7dABf_zsWhtpFAfCGWw3j5BD90LihFZwfnwYELNrVmmvhEppCcVnKWg

https://www.psychologytoday.com/us/blog/the-breakthrough-depression-solution/201106/low-cholesterol-and-its-psychological-effects?fbclid=IwAR16K8qbmSWvade_0goViB_qqbMziQZIdJ6Ss71h_l4NW9E3ByR5JJURJ74#_=_

Cholesterol is needed to keep the brain healthy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5286209/?fbclid=IwAR0Kpo9aodSutexBOov9zLs4BpM2o-f_shIkJPWuJKJ3rScb-xJeSQsJgUw

Inflammation if not addressed can lead to cardiovascular disease. Inflammation is a sign the body is trying to heal and we need to assist it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590813/

https://academic.oup.com/ajcn

https://www.livescience.com/52344-inflammation.html

https://www.nejm.org/doi/10.1056/NEJMoa1707914

https://drhyman.com/blog/2010/05/19/why-cholesterol-may-not-be-the-cause-of-heart-disease/?fbclid=IwAR0I_C6y2m7ppuel84eFRH7aSAsdo1tNgLsSYd_vCJMDE7WilRg_m1udn5E

There are many things that can cause high C Reactive levels in the blood. This causes inflammation. Tick born illness and many other infections can cause it. Toxins like glyphosate can cause high C Reactive levels and it has been found to be high in much of the food we consume. Also heavy metals and vaccine injury can cause high C Reactive levels. So it is very important to address these things to get our C Reactive levels down.

https://www.healthline.com/health/c-reactive-protein

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958648/?fbclid=IwAR23-JJyi3hY1oxcAn-_iSShBppwQ2NjsD29G4qrZMgzrCsn-XHfmGsB9CM

Flouride found I chorinated water, mouthwash and toothpaste causes hardening of the artieries.

https://www.ncbi.nlm.nih.gov/pubmed/26625626?fbclid=IwAR3CISFWVwgcY8i3G4lQPLbZZBD2UOal-WYo6-OWAkOuQqub73envxAZDfA

 

Aluminum which is found in vaccine adjuvants causes hardening of the artieries.

https://www.ncbi.nlm.nih.gov/pubmed/22178028?fbclid=IwAR3OlrzeWgcQwDwLJ6ENjPXq_Esy3IPmvdAt4YC5L07whte-WiS7eCzDQ1k

Many things cause oxidative stress, heavy metals, vaccine injury, infection, farm chemicals found in our food especially glyphosate. If we do not address the oxidative stress it can lead to heart disease.

https://chriskresser.com/what-causes-elevated-ldl-particle-number/

https://www.hindawi.com/journals/omcl/2016/1543809/

https://www.hindawi.com/journals/ccrp/2012/290805/

Low cholesterol damages the brain.

http://www.indianjpsychiatry.org/article.asp?issn=0019-5545;year=2017;volume=59;issue=4;spage=478;epage=482;aulast=Shrivastava

Cholesterol dysfunction can lead to autism.

http://www.beyondmthfr.com/side-high-oxalates-problems-sulfate-b6-gut-methylation/

https://www.theautismexchange.com/organized-information/biomedical/conditions/low-cholesterol

 

I could literally post hundreds of studies showing vaccines damage the heart.

https://www.ncbi.nlm.nih.gov/pubmed/20964738

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118283

Our bodies cannot make hormones without cholesterol and those are needed by every part of the body and dramatically effects the brain.

https://metabolichealing.com/cholesterol-your-body-is-incapable-of-making-hormones-without-it/

https://www.greatplainslaboratory.com/articles-1/?fbclid=IwAR3BBiR_U659SqOhd9Ei6J_kW6K_9QTbYH0bGOwflx1Q0aXBNGebobL9zdU

Truth About Statins and cholesterol lowering drugs.

This summarizes the preceding links on the effects of statins our a persons health.

https://www.westonaprice.org/health-topics/modern-diseases/dangers-of-statin-drugs-what-you-havent-been-told-about-popular-cholesterol-lowering-medicines/

Side effects of Lipitor and other statins.

https://www.rxlist.com/lipitor-side-effects-drug-center.htm

Now the statin research shows that it causes hypocholesterolemia which means a deficiency in cholesterol. They view that as a good thing but if you look at the proceeding research your will see that has a very bad impact on a persons health.

https://www.ncbi.nlm.nih.gov/pubmed/22338462?fbclid=IwAR0HKgqw7ThyMAqtP3P2oJoSimmlxtzpvt3kMcqZr3YiD2QhtQ0evqcvypA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741209/?fbclid=IwAR1PVc-bk0P3-xw3HMeLHnbmeKUNbXh4d7-LBvtzTZ8xwrBHqjCyS-dCCdM

https://www.statineffects.com/info/adverse_effects.htm

Statins increase risk of stroke.

https://www.ncbi.nlm.nih.gov/pubmed/1627030

https://www.strokejournal.org/article/S1052-3057(11)00163-7/fulltext

https://www.ncbi.nlm.nih.gov/pubmed/23839705?fbclid=IwAR3LeBO6m7PBr2YIZ1fHMFKQFJnfXLljVK3WgINrLB1Bgb7ipUwOWGboJQI

Low cholesterol increases risk of stroke.

https://www.ncbi.nlm.nih.gov/pubmed/8124144

https://www.jstage.jst.go.jp/article/jcj/63/1/63_1_53/_article

https://www.ncbi.nlm.nih.gov/pubmed/9851379

Statins destroy the brain because they are neurotoxic.

http://annals.org/aim/article-abstract/716909/atorvastatin-induced-polyneuropathy?volume=139&issue=9&page=792

https://www.ncbi.nlm.nih.gov/pubmed/16940411

https://www.ncbi.nlm.nih.gov/pubmed/14695047

https://www.ncbi.nlm.nih.gov/pubmed/12885101

https://www.ncbi.nlm.nih.gov/pubmed/16765141

https://www.ncbi.nlm.nih.gov/pubmed/20473136

https://www.ncbi.nlm.nih.gov/pubmed/15589485

http://jpn.ca/vol41-issue1/41-1-56/

https://www.ncbi.nlm.nih.gov/pubmed/17057271

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005588/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487843/

Discontinuing statin use restores memory.

https://www.ncbi.nlm.nih.gov/pubmed/19558254

https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-016-0877-8

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2301148?fbclid=IwAR0VkRCu0mgvDZVcfzMcXu–eN1Pq8WjTQleNN-0iFHLzVP5YogV381pJtw

Statins inhibit the very pathway needed to fight infection which causes autoimmunity. Autoimmunity can also lead to cancer.

https://www.ncbi.nlm.nih.gov/pubmed/17944002

https://www.ncbi.nlm.nih.gov/pubmed/23426088

https://www.ncbi.nlm.nih.gov/pubmed/20483407

https://www.ncbi.nlm.nih.gov/pubmed/20704607

https://www.ncbi.nlm.nih.gov/pubmed/20491794

https://www.ncbi.nlm.nih.gov/pubmed/18161561

https://www.ncbi.nlm.nih.gov/pubmed/18485436

https://www.nature.com/articles/nrneurol.2011.63

https://journals.lww.com/md-journal/Citation/1998/11000/Systemic_Immune_Reactions_to_HMG_CoA_Reductase.2.aspx

https://www.nature.com/articles/s41598-017-15546-8

https://www.ncbi.nlm.nih.gov/pubmed/22502740

https://www.ncbi.nlm.nih.gov/pubmed/17207162

http://cebp.aacrjournals.org/content/22/9/1529.long

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000500020&lng=en&nrm=iso&tlng=en

https://www.ncbi.nlm.nih.gov/pubmed/21943022

https://www.ncbi.nlm.nih.gov/pubmed/19813188

https://www.ncbi.nlm.nih.gov/pubmed/21360500

Statins cause lupus.

https://www.ncbi.nlm.nih.gov/pubmed/17207162

https://www.ncbi.nlm.nih.gov/pubmed/15118389

Statins can cause hepatitis and kidney damage.

https://journals.lww.com/jcge/pages/articleviewer.aspx?year=2006&issue=09000&article=00018&type=abstract

https://www.ncbi.nlm.nih.gov/pubmed/17147462

https://www.bmj.com/content/340/bmj.c2197.long

https://www.ncbi.nlm.nih.gov/pubmed/23511950

The many ill health effects of statins have been proven but the safety and effectiveness still has not been proven.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960491/

https://www.ncbi.nlm.nih.gov/pubmed/1745460

Statins have been linked to diabetes.

https://jamanetwork.com/journals/jama/fullarticle/646699

https://www.ncbi.nlm.nih.gov/pubmed/19913318

https://www.ncbi.nlm.nih.gov/pubmed/21920996

http://www.greenmedinfo.com/article/statin-drugs-increase-risk-diabetes

https://www.ncbi.nlm.nih.gov/pubmed/20934984

https://journals.lww.com/optvissci/fulltext/2012/08000/Age_Related_Cataract_Is_Associated_with_Type_2.12.aspx

https://www.ncbi.nlm.nih.gov/pubmed/21995692

https://www.ncbi.nlm.nih.gov/pubmed/25754552

https://www.statineffects.com/info/adverse_effects.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156828/

Statins increase risk of cancer.

http://www.cmaj.ca/content/176/5/649.long

https://www.sciencedirect.com/science/article/pii/S0735109707015574?via%3Dihub

https://www.ncbi.nlm.nih.gov/pubmed/18707867

Statins damage the lungs.

https://www.ncbi.nlm.nih.gov/pubmed/18689579

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(15)00393-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413115003939%3Fshowall%3Dtrue

Statins cause inflammation.

https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2687990?fbclid=IwAR03PQS4hohrhdzwnzZ3ZNuLJ4rl_hOELO9sJSsD3rkUR9c8uoltpqYiNv0

Statins reduce CoQ10 which results in muscle decline and mental decline.

https://www.ncbi.nlm.nih.gov/pubmed/26192349

https://jamanetwork.com/journals/jamaneurology/fullarticle/786017

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096178/

https://www.jstage.jst.go.jp/article/jat/12/2/12_2_111/_article

https://www.ncbi.nlm.nih.gov/pubmed/2247468

https://www.ncbi.nlm.nih.gov/pubmed/8463436

https://www.tandfonline.com/doi/abs/10.1080/15376510802305047?journalCode=itxm20

https://jamanetwork.com/journals/jamaneurology/fullarticle/789882

https://www.ncbi.nlm.nih.gov/pubmed/14695926

Statins damage the muscles.

This links explains the symptoms of the myopathy.

https://www.healthline.com/health/what-is-statin-induced-myopathy-or-muscle-pain

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1691918

https://academic.oup.com/jcem/article-abstract/103/1/75/4364961?redirectedFrom=fulltext

https://academic.oup.com/toxsci/article/88/2/551/1691165

https://www.ncbi.nlm.nih.gov/pubmed/9322808

https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2710.2001.00360.x

https://www.ncbi.nlm.nih.gov/pubmed/16453090

https://www.ncbi.nlm.nih.gov/pubmed/16892458

https://www.ncbi.nlm.nih.gov/pubmed/16799920

https://www.ncbi.nlm.nih.gov/pubmed/16003294

https://www.ncbi.nlm.nih.gov/pubmed/22205938

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487843/

Statins cause cholesterol escape phenomena and they do not know the consequences.

https://www.wjgnet.com/2220-315X/full/v7/i1/25.htm

Statins cause antiphospholipid syndrome which can lead to endothelial damage. Farm chemicals and vaccine injury can also cause it.

https://www.ncbi.nlm.nih.gov/pubmed/22389514

https://www.ncbi.nlm.nih.gov/pubmed/20383667

Vaccine inujury, mycoplasma infection, heavy metals , and farm chemicals can cause autoimmunity. This can lead to antiphospholipid syndrome which leads to many forms of chronic illness..

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389016/

If you show sign of antiphopholipid syndrome it is very important to prevent thrombosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389011/

Statins contribute to heart disease.

https://www.ncbi.nlm.nih.gov/pubmed/15871849

https://www.ajconline.org/article/S0002-9149(04)01235-4/fulltext

https://www.ncbi.nlm.nih.gov/pubmed/24410834

https://www.ncbi.nlm.nih.gov/pubmed/21840000

https://onlinelibrary.wiley.com/doi/abs/10.1002/clc.20644

Statins cause hardening of the arteries.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476911/

https://www.ncbi.nlm.nih.gov/pubmed/28036114

https://www.ncbi.nlm.nih.gov/pubmed/22981406

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031639

https://www.ncbi.nlm.nih.gov/pubmed/26718960

https://www.tandfonline.com/doi/abs/10.1586/17512433.2015.1011125?journalCode=ierj20

A drug that needs mentioned is fluoroquinolones. They damage the whole body especially the heart. The proceeding links will explain POTS. It is when you get dizzy when standing or taking a hot shower. It is life threatening but most cardiologist and doctors brush it off.

https://www.bmj.com/content/349/bmj.g6196

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2451282

Infections can cause heart disease.

http://www.dysautonomiainternational.org/blog/wordpress/a-tale-of-two-syndromes-pots-and-mcas/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597284/?fbclid=IwAR3MIMR3h-Z-eVyZb1yzwFFnPHE182gKmVaKwsuMXTkAbagXt5Jd4eyGsXs

https://www.ahajournals.org/doi/abs/10.1161/01.atv.20.6.1536?fbclid=IwAR2nQmEgSihuAmsusrzHtbsK9AajnTwS1PlwQbxe2kuhemyZpspCCHuKuZc

Tick born illness can cause heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435605/

https://thelymewire.blogspot.com/2016/03/lyme-disease-broke-my-heart-what-is.html?m=1

https://myheart.net/pots-syndrome/lyme-disease/

https://academic.oup.com/cid/article/59/7/996/2895341

Dental infections can cause heart disease.

https://onlinelibrary.wiley.com/doi/abs/10.1902/jop.2005.76.11-S.2085?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&fbclid=IwAR2BTDetQbNH9M2sRG_84aAwN6gI4yH3uKiMPpSolC52u_HzstsF9i8U6Pg

https://www.clin-lab-publications.com/article/2558?fbclid=IwAR0DKiYGyeP5oX479-lAqgWGYDbxTlDji315rU0uBAH6zY5INBEegdnfNzY

Mast Cell Activation Syndrome can cause POTS. Vaccine injury , farm chemicals which contaminate our food can cause it. Toxins especially heavy metals can cause it and nutrient deficiencies can cause MCAS,

http://www.mastcellaware.com/mast-cells/related-conditions.html

https://www.ncbi.nlm.nih.gov/pubmed/15710782/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906415/

https://www.atherosclerosis-journal.com/article/S0021-9150(17)31415-6/fulltext

Farm chemicals especially glyphosate causes heart disease. Glyphosate is found to be in most of our food supply.

https://link.springer.com/article/10.1007/s12012-014-9299-2

https://www.tandfonline.com/doi/abs/10.3109/15563650.2010.496730?journalCode=ictx20#.WGRzWK-mm5s.facebook

https://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-6/The-syndromes-of-Orthostatic-Intolerance-Title-The-syndromes-of-Orthostatic-I

Vaccine induced heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368609/

http://journals.sagepub.com/doi/abs/10.1177/021849230601400627?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3Dpubmed

https://www.ncbi.nlm.nih.gov/pubmed/21781156

https://www.ncbi.nlm.nih.gov/pubmed/20964738

https://www.sciencedirect.com/science/article/pii/S0264410X15004375?via%3Dihub

We know oxidative stress causes heart disease.

https://febs.onlinelibrary.wiley.com/doi/full/10.1016/S0014-5793(97)00609-1

Sleep deprivation causes heart disease. Statins cause sleep deprivation.

https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1038/clpt.1991.213

High TMAO levels cause heart disease. This is usually the result of gut dysbiosis caused by antibiotics and other pharmaceuticals, artificial sweeteners can cause it, also farm chemicals especially glyphosate can cause it.

https://www.selfhacked.com/blog/tmao/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127123/

https://link.springer.com/article/10.1007/s10157-015-1207-y

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682319/

Leaky gut and our gut bacteria effect the health of our whole body. It raises histamines which cause hypertension or carditis.

https://bodyecology.com/articles/do-you-have-histamine-intolerance-4-steps-to-rebuild-tolerance

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705355/

https://health.clevelandclinic.org/how-gut-bacteria-may-help-curb-heart-disease/

http://www.allergynutrition.com/wp-content/uploads/2014/05/Histamine-DAO-and-Probiotics-Revised.pdf

http://www.jimmunol.org/content/198/2/572

How Glyphosate effects the gut and health of the body.

https://detoxproject.org/glyphosate/glyphosate-and-roundup-negatively-affect-gut-bacteria/

http://www.mdpi.com/1099-4300/15/4/1416

https://www.ncbi.nlm.nih.gov/pubmed/25245870

https://people.csail.mit.edu/seneff/SamselSeneffGlyphosateIV.pdf

https://www.researchgate.net/publication/305318376_Glyphosate_pathways_to_modern_diseases_V_Amino_acid_analogue_of_glycine_in_diverse_proteins

http://www.amsi.ge/jbpc/11717/25SA16A.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008745/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596485/

Vitamin B12 status can effect our heart. I do not say deficiency because in some they could have high B12 levels but if they have high levels of farm chemicals from eating foods that contain them it will inhibit their bodies ability to convert it to a usable for. Those who are not converting will get headaches when they take B12 and my feel ill. Often times because they know low B12 can cause irregular heart beats they will give IV B12 which can make someone who is not converting very ill.

https://www.sciencedirect.com/science/article/pii/S0165183898000587
There are many things that can effect bile acid production. If it is inhibited we can develop diabetes because it can effect the whole body including the heart. It also effects the pancreas and when it is inhibited the pancreas will produce less digestive enzymes which will make our food sit in our digestive tract and ferment. This will make us bloated and will make it feel like we have a heavy weight sitting in our guts. This can cause H Pylori and Candida to go from commensal to pathogenic form. I have posted on how to balance our gut bacteria. It can also cause us to develop either acidosis or alkalosis. If you have candida you will have alkalosis and will experience anxiety and difficulty sleeping. If you have acidosis you will be very drowsy and experience episodes of severe depression. I have posted on all the above mentioned.

https://www.karger.com/Article/Abstract/282091

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413465/

http://www.phytochemicals.info/plants/olive.php

Metabolic and autoimmune issues can cause heart diesease.

https://academic.oup.com/ajcn

 

I have posted on sulfites and sulfation. If we have high sulfite levels or we have sulfation issues it can cause heart disease. Sulfur is very important for regulating many things throughout the body including hormones and blood pressure. Glyphosate, glufosinate and mercury inhibit sulfation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725894/

This can effect BH4 levels. Green Tea raises BH4 levels but must be used in moderation because over use can raise histamine levels.

http://www.j-circ.or.jp/english/sessions/reports/71st/sym10.htm

http://www.life-enhancement.com/magazine/article/3721-green-tea-re-establishes-tetrahydrobiopterin-levels-in-human-diabetics

https://www.fasebj.org/doi/abs/10.1096/fasebj.30.1_supplement.737.6

Proteinuria can be brought on by many things. It can be corrected but could be a sign there are high sulfite levels or sulfation issues. If not addressed it can lead to diabetes, heart disease and even death.

http://m.cjasn.asnjournals.org/content/2/1/58.full

How our lifestyle can effect our heart and our sex life.

https://www.pritikin.com/your-health/health-benefits/reverse-heart-disease/331-sex-nitric-oxide-and-your-heart.html

Stress cannot be avoided that is why it is necessary to work on learning to handle stress and not let it overwhelm us. It has a very bad impact on on our health especially the cardiovascular system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144755/

 

This is talking about genetic issues and autoimmune disorders that can cause heart disease. We know many of these negative epigenetic changes are caused by man and can be corrected. Most autoimmunity is induced by man with toxins like glyphosate, heavy metals and vaccines. We must address those to correct the cardiovascular issues.

https://www.ncbi.nlm.nih.gov/pubmed/28982122

Trans Fats found in fast food and processed food causes cardiovascular disease.

https://www.nature.com/articles/1602973

Discussion of nutrients and their effects on blood pressure and what deficiencies do to the cardiovascular system.

https://www.ncbi.nlm.nih.gov/books/NBK92767/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963918/

Those with cardiovascular disease have been found to be low in certain nutrients which causes high homocysteine levels.

https://www.sciencedirect.com/science/article/pii/S0009898105002378

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541701/

Issues with Lipocalin 2 can cause heart disease. It modulates iron hemiostasis. Gut dysbiosis, infection, farm chemicals, heavy metals and antibiotics can disrupt Lipocalin 2 function.

 

https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-015-0129-z

 

 

 

Things that may help with heart disease.

Fiber from plantain reduces risk of heart disease.

https://www.ncbi.nlm.nih.gov/pubmed/30078477

Cholesfytol reduces heart disease.

https://www.ncbi.nlm.nih.gov/pubmed/29154060

Green Tea reduces LDL.

https://www.ncbi.nlm.nih.gov/pubmed/27806972

Beta Glucan found in oatmeal reduce oxLDL. It is also found in mushrooms.

https://academic.oup.com/nutritionreviews/article-abstract/69/6/299/1815168?redirectedFrom=fulltext

Fiber reduces oxLDL.

https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(03)00299-7/fulltext

Reducing oxidative stress reduces hypertension. Cholesterol reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543092/

https://www.lifeextension.com/Magazine/2011/5/Natural-Ways-to-Thwart-a-Stealth-Killer/Page-01

Fasting reduces oxLDL and repairs the heart.

https://idmprogram.com/fasting-lowers-cholesterol-fasting-16/

https://www.thieme-connect.com/DOI/DOI?10.1055/s-0042-110856

I did a blog post on things that reduce oxLDL.

https://iamajuicer.wordpress.com/2018/06/16/reducing-cholesterol-ldl-is-a-symptom-not-a-cause/

These are things that help with POTS.

https://www.leaf.tv/articles/holistic-cure-for-neurocardiogenic-syncope/

http://www.raysahelian.com/arrhythmia.html

 

Things that help lower TMAO. Some nutrients do and so do some probiotics.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904929/

https://link.springer.com/article/10.1007%2Fs13167-017-0117-3

https://www.cell.com/cell/fulltext/S0092-8674(15)01574-3

This is a list of nutrients that help with heart disease and it discussed why they work. It helps to put into perspective some of the causes of heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277260/

https://openheart.bmj.com/content/5/1/e000668

The Mediterranean diet reduces heart disease because it reduces oxidative stress and inflammation. They mention curcumin in here. It has amazing healing abilities but chelates iron from the body so it is something that should be used in moderation so a person does not make themselves anemic. It should not be a problem in the U.S. because GMOs and glyphosate cause nutrient deficiencies so they fortify the foods with iron. Because of that many have very high levels of iron which can cause heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228762/

This paper reviewed the research on fats and their effects on the body. Omega 3s help reduce heart disease including myocarditis. But there is times only fats can cause problems. If a person has pyrrole issues which can be a symptom of porphyria they will have problems with fats. It is a very serious health problem that can be corrected with the correct nutrients and lifestyle changes. I have posted in it. There are a number of types of Omega fatty acids. The American diet is high in Omega 6 which has been shown to cause inflammation. Omega 3 Fatty acids should be at a higher level then Omega 6 in the body. Because they are involved in the regulation of many metabolic pathways, consuming too much Omega 6 can cause many health problems. Metabolic syndrome is a cause of diabetes and heart disease.

http://care.diabetesjournals.org/content/26/11/3153

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067287/

https://www.omicsonline.org/open-access/omega-omega-and-omega-fatty-acids-implications-for-cardiovascular-and-other-diseases-2153-0637.1000123.php?aid=35367

Histidine helps protect the heart. This may seem confusing but if you read my post on high and low histamines it will explain. Histidine deficiency can cause many negative health effects. Aromatase enzyme are important for it’s proper function. Glyphosate, glufosinate and some foods can inhibit aromatase which can raise ammonia levels in the body resulting in alkalosis. Histidine is important in our response to stress.

https://www.sciencedirect.com/science/article/pii/S0928425799801533?via%3Dihub

http://deficiencynetwork.com/histidine-deficiency/

https://aminoacidstudies.org/l-histidine/

Now the bad and it shows the importance of nutrients and homeostasis. A folate deficiency (not folic acid it is toxic) can raise histidine levels which can cause histamine levels to go too high resulting in chronic illness. So the most important thing is to focus on balancing nutrient and histidine levels.

http://nancymullanmd.com/dr-amy-yasko-allergic-reactions-mast-cell-activation-syndrome/

This is a good article explaining histamines in depth.

http://www.iainfoctr.com/articles/histamine.php

Heart attack occur more in the winter because of vitamin D deficiency. Guess where Eskimos got their vitamin D. From the animal fat they consumed.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662093/

The way we breath can effect our blood pressure. Breathing deeply can lower blood pressure. If we have acidosis we will breath quickly and shallow to reduce CO2 levels which will reduce the acid levels. If we have alkalosis we may breath deeply and very slowly almost to the point were take very few breaths per minute. We must address the issues that are causing the alkalosis or acidosis before breathing will be effective.

https://healthhearty.com/deep-breathing-exercises-to-lower-blood-pressure

https://www.normalbreathing.com/learn-8-diaphragmatic-breathing.php

The ketogenic diet has been shown to help with oxLDL but I do not believe in staying on one specific diet. The body was made to consume a variety of foods and once homeostasis is achieved I feel it is better to start adding other types of foods to the diet.

https://www.ruled.me/the-ketogenic-diet-and-cholesterol/

Now on the other side of the coin too much potassium can cause problems that is why we should always focus on homeostasis.

 

https://healthyeating.sfgate.com/dangers-much-potassium-body-4817.html

Endothelins role in cardiovascular disease and how to decrease them.

https://www.selfhacked.com/blog/endothelins/?utm_source=ActiveCampaign&utm_medium=email&utm_content=The+Latest+From+SelfHacked&utm_campaign=Jan282018+Newsletter

Aldosterone though not an herb regulates water and electrolyte balance in the body which can have dramatic effects on our blood pressure and the heart. Sodium Bicarbonate in the mineral water helps with hypertension also.

https://www.selfhacked.com/blog/need-know-aldosterone-health-effects/

https://www.jems.com/articles/print/volume-35/issue-12/patient-care/sodium-bicarbonate.html

https://www.ncbi.nlm.nih.gov/pubmed/16490643

Black Sativa is a super food. It could be listed in just about any healing remedies from diabetes to mental illness. It also helps with high blood pressure and carditis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387232/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387229/

Butyric Acid also known as butyrate is great for healing throughout the body. It is produced by our gut bacteria when we eat fiber, consume milk products and certain carbohydrates. It is needed by the brain and helps fight inflammation and oxidative stress. When deficient in it we can develop leaky gut which can lead to heart disease.

https://wholehealthsource.blogspot.com/2009/12/butyric-acid-ancient-controller-of.html?spref=fb

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070119/

PQQ is another nutrient that has amazing healing properties. It even helps heal neurological damage.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140972/

Okra is another plant with amazing healing properties. It is in the mallow family, most plants in the mallow family have amazing health benefits.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371438/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178946/

Cissus has too many benefits to list.

https://www.organicfacts.net/health-benefits/other/cissus-quadrangularis.html

Peas are ACE inhibitors but you have to make sure they are organic. The farm chemicals on non organic cause heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163438/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409655/

Rice bran is an antioxidant and is an ACE inhibitor.

https://www.sciencedirect.com/science/article/pii/S0023643816305333

Sunflower seeds reduce the chances of heart disease. You have to make sure they are from a source that is grown in soil that is not contaminated. They are very good at pulling radiation from the soil. If you sprout them they are more nutritious.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622016/

Nattokinase thins the blood , it helps with thrombosis by preventing blog clots.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479826/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654648/

https://www.sciencedirect.com/science/article/pii/S0271531709000220?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372539/

Gingko inhibits bradykinin which contributes to tachycardia. But I have seen a study that showed that renal damage starts to occur if taken for an extended amount of time. It really helped me with my brain fog but I had a strange reaction to it. The first couple of days I got a really bad headache when I took it. But I continued to take it and on about the fourth day I could feel my brain fog starting to lift. I still take it once in a while to help keep the brain fog from coming back but until I am certain of the toxicity I will not take it often. I have only seen one study on the toxicity and there was a lot of data missing leaving me uncertain if it was the gingko that caused the renal damage. Sophora root helps with just about any type of heart disease. It really helped my carditis.

https://www.worldscientific.com/doi/abs/10.1142/S0192415X16500907?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

Be pollen is a supper food. It has many proteins that the body can easily use without having to work hard to use. It also has many minerals the body needs. Hence it reduces inflammation which causes arteriosclerosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748819/

Burdock reduces inflammation and oxidative stress. Diabetes and heart disease can be caused by oxidative stress and inflammation which leads to metabolic disorders. Burdock also helps with metabolic disorders.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355822/

Mugwort raises GABA which causes relaxation and is a calcium channel blocker. They claim thujone is toxic but it takes a very high amount to become toxic. They often do things like that , and I believe it is to deter people from healing so they can keep them on the allopathic hamster wheel. Yeah they tell people to take high levels of iron which is toxic and most in the U.S. have been found to have levels of iron that are too high which causes oxidative stress. Mugwort which has the same phytochemicals as wormwood reduces hypertension.

https://ecommons.aku.edu/cgi/viewcontent.cgi?referer=https://swisscows.com/&httpsredir=1&article=1032&context=pakistan_fhs_mc_bbs

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512891/

https://www.ncbi.nlm.nih.gov/pubmed/11321437

Rooibos is another amazing herb. It reduces inflammation and prevents thrombosis. It also kills many pathogens especially in the lungs. It also improves breathing.

https://link.springer.com/article/10.1007%2Fs12272-014-0501-7

Bacopa helped me a lot it is great for healing the blood vessels and for reducing inflammation and oxidative stress. This also reduces symptoms of carditis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319078/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843280/

Berberine reduces inflammation, heals the liver and fights many pathogens. It helps lower blood pressure because of it’s healing properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341350/

Virgin olive oil has many healing abilities and inhibits our gut bacterias ability to produce TMAO so it reduces blood pressure and risk of heart disease.

https://www.sciencedirect.com/science/article/pii/S0009912004001201?via%3Dihub

Honeyberry a type of honesuckle is great for healing and preventing cardiovascular disease.

http://biomed.papers.upol.cz/artkey/bio-200702-0001_BERRY_FRUITS_AS_A_SOURCE_OF_BIOLOGICALLY_ACTIVE_COMPOUNDS_THE_CASE_OF_LONICERA_CAERULEA.php

This is a type of fleabane. I have looked at the phytochemicals of the various species of fleabane it they are very similar . Most in the fleabane family have the same health benefits which are numerous. They help reduce the risk of cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969545/

Plant polyphenols reduce cardiovascular disease by preventing thrombosis and preventing blot clotting. They thin the blood.

http://www.jbc.org/content/285/11/7892.full

Soursop prevents thrombosis.

https://www.nature.com/articles/srep36462

Kudzu has many benefits and has been shown to help reduce blood pressure. When I was very ill it helped me a lot.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784920/

Many spices help with heart disease and other chronic illness because they reduce inflammation.

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1381-2

There are many natural sources of ACE inhibitors that usually do not cause the side effects or dangers involved with pharmaceuticals.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896793/

Some cheeses will raise histamines but others actually work as ACE inhibitors.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976624/

The flavoniods in the white part of citrus fruits helps with cardiovascular disease.

https://academic.oup.com/advances/article/5/4/404/4568623

Taxifolin also known as isoquerciten has amazing healing abilities. It is found in milk thistle and has been shown to reduce carditits and high blood pressure.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825014/

Galinsoga is another plant with amazing healing abilities throughout the body.

http://www.juliasedibleweeds.com/edible-weeds-flowers/galinsoga/

Heat Shock Protein 70 can effect our blood pressure and this discusses how to raise and lower it.

https://www.selfhacked.com/blog/heat-shock-proteins-hsp70-increase-decrease/

Butchers Broom heals the blood vessels. This one helped me a lot it has many healing properties.

http://www.womens-health-club.com/herbs/butchers-broom.htm#.WJ7YZ-SzYpU.facebook

This is a type of Golden Rod. Most of the golden rod has similar photchemicals. They are very high in quercitren so are very good for healing.

https://www.ncbi.nlm.nih.gov/pubmed/25898223

Low oxygen levels can be caused by acidosis, infection, oxidative stress , COPD and many other health issues. This causes high blood pressure.

http://jcs.biologists.org/content/125/24/6117

PEA helps fight the common cold and flu because it reduces inflammation so would also help hypertension since inflammation causes hypertension.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771453/

https://www.sciencedirect.com/science/article/abs/pii/S1043661814000656

Maca root seems to inhibit N-acyletholamine acid which would increase PEA levels.

https://www.jeffreydachmd.com/wp-content/uploads/2016/06/Fatty-Acid-Amide-Hydrolase-FAAH-Inhibitors-Lepidium-meyenii-Maca-Vu-Huyen-NCUR-2012.pdf

Oxazolidone inhibits NAAA increasing PEA levels.

https://www.sciencedirect.com/science/article/pii/S0223523417306074

Antibiotics derived from penicillin inhibit NAAA unfortunately I am allergic to penicillin.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117721/

Metabolic syndrome causes an number of illnesses and hypertension and cardiac disease is a few of them. This is a list of plants and their effects are metabolic syndrome.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755736/

Pomegranate has been shown to be an ACE inhibitor. I have found more benefits from eating the seeds then drinking the juice.

https://www.atherosclerosis-journal.com/article/S0021-9150(01)00412-9/fulltext

Astaxantan helps reduce oxidative stress and inflammation. It is high in krill oil.

https://link.springer.com/article/10.1007%2Fs11130-011-0258-9

Prickly Lettuce also known as Opium Lettuce helps protect the heart but must be used in moderation because it has a chemical in it similar to opium but is not addictive.

https://www.ncbi.nlm.nih.gov/pubmed/27476284

Saffron is another one of those herbs that has amazing healing abilities. It helps with carditis and hypertension.

https://www.tandfonline.com/doi/full/10.3109/13880209.2013.767362

Self heal helps fight viruses, inflammation and oxidative stress. It is an Nrf2 activator so it would help with Nrf2 issues which would help with many forms of chronic illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269750/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133916/

Purslane is a super food, it contains almost all the nutrients needed by the body. It has been found to help with heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137030/

Garlic helps with cardiovascular disease. You have to make sure you do not have high sulfite levels or sulfation issues. If you do it will make you worse.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753981/

Wild violet is one of my favorite to eat. It has great anti-inflammatory and antioxidant properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286389/

Flaxseed has many healing properties because it has Omega 3 in it. It must be crushed because we cannot digest it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989356/

Grape seed extract is another that has many amazing healing abilities and protects the cardiovascular system. The only draw back with grape seed extract is that it is high in resveratrol which give it many healing abilities but resveratrol can activate the hepatitis virus so those with hepatitis my want to avoid it and use other herbs that will prevent inflammation and thrombosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370781/

There are many plant sources of things that help with cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405360/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677329/

Paeonia root helps prevent thrombosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878539/

Corn silk is another thing that has many health benefits including preventing heart disease.

https://www.sciencedirect.com/science/article/pii/S2214750015000487

Camu Camu has many healing abilities so helps with cardiovascular disease. It raises GABA levels which helps with sleep and relaxation.

https://www.sciencedirect.com/science/article/pii/S0914508708001500

Grass fed but is one of the best things for any type of illness.

https://www.healthline.com/nutrition/grass-fed-butter-superfood-for-the-heart

Lycopene is great for healing one of the best sources of it are cooked tomatoe skins.

https://www.spandidos-publications.com/mmr/11/1/374

Thiamine deficiency can lead to hypertension and chronic illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754670/

Those who are G6PD deficient or have certain metabolic issues would get ill from the foods that contain thiamine so they may have to supplement thiamine until they have corrected those issues.

https://draxe.com/thiamine-foods/

Hawthorne leaves and fruit have many health benefits. They help with hypertension and carditis. They have also been found to fight many forms of cancer.

https://darujps.biomedcentral.com/articles/10.1186/s40199-015-0137-2

https://link.springer.com/article/10.1007%2Fs10753-014-9863-8

https://onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.5671

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD005312.pub2/full

https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0030-1270849

https://www.aafp.org/afp/2010/0215/p465.html

White malberry helps with hypertension.

https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201600233

Nattokinase helps prevent thrombosis. Thrombosis can be a result of infection especially tick born illness and vaccine injury which causes antiphospholipid syndrome. This can result in cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479826/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654648/

http://www.scielo.br/scielo.php?pid=S0365-05962005000300002&script=sci_arttext&tlng=en

https://www.hindawi.com/journals/jir/2014/621270/

This is how nattokinase prevents heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372539/

Rooibos also helps prevent thrombosis.

https://link.springer.com/article/10.1007%2Fs12272-014-0501-7

Arjuna inhibits thrombosis which helps with cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220499/

There are many other naturals that help inhibit thrombosis.

http://www.jbc.org/content/285/11/7892.full

I have posted on HSP70 it prevents thrombosis without causing excessive bleeding.

https://academic.oup.com/cardiovascres/article/110/3/309/1744740?searchresult=1

Tenascan-C is needed for heart repair. But if it is too high it can cause health problems. Homeostasis should be the goal.

https://www.nature.com/articles/srep04051

https://www.frontiersin.org/articles/10.3389/fphys.2014.00283/full

Tenascan-C is high in COPD

https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-12-48

High tenascan-c levels increases risk of cancer.

http://jcb.rupress.org/content/160/2/171

Vitamin B6 deficiency can lead to heart disease.

https://www.sciencedirect.com/science/article/pii/S0899900706003224

https://academic.oup.com/ajcn/article/81/3/725/4649116

https://paulaowens.com/vitamin-b6-deficiency/

Flavonolignans help prevent thrombosis.

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-017-1897-7

Ghrelin anti-aging mechanism.

http://www.mdpi.com/1422-0067/18/7/1511

Beta glucan reduces risk of heart disease and has many other beneficial properties.

http://www.mdpi.com/1422-0067/18/9/1906/htm

Reduces blood pressure.

https://academic.oup.com/ajcn/article/104/6/1534/4564684

https://link.springer.com/article/10.1007%2Fs00125-014-3305-x

Rooibos protects the heart by reducing oxidative stress and by reducing inflammation. Rooibos is also an ACE inhibitor.

https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-017-0200-8

https://www.ncbi.nlm.nih.gov/pubmed/22095883

Tenascan-C is needed for heart repair. High Tenascan-C levels can cause heart problems so the goal should be homeostasis.

https://www.nature.com/articles/srep04051

https://www.frontiersin.org/articles/10.3389/fphys.2014.00283/full

Tenascan-C is high in COPD

https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-12-48

High tenascan-c levels increases risk of cancer.

http://jcb.rupress.org/content/160/2/171

http://cancerres.aacrjournals.org/content/66/24/11771

High fat diet decreases cholesterol.

http://m.ajcn.nutrition.org/content/70/6/1009.full

https://www.healthline.com/nutrition/grass-fed-butter-superfood-for-the-heart

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989356/

https://www.omicsonline.org/open-access/omega-omega-and-omega-fatty-acids-implications-for-cardiovascular-and-other-diseases-2153-0637.1000123.php?aid=35367

Cod Liver oil

https://www.ncbi.nlm.nih.gov/pubmed/12415563

https://www.ncbi.nlm.nih.gov/pubmed/2718528

Omega 3s help.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0061109

Fulvic Acid reduces LDL

http://www.sciencedirect.com/science/article/pii/S1063458408001702

Astanxathin reduces cholesterol by reducing oxidative stress.

https://www.ncbi.nlm.nih.gov/pubmed/21964877

Bacopa reduces inflammation and heals blood vessels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319078/

Grape Seed extract reduces inflammation and blood pressure.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370781/

Flavoniods in fruits and vegetables help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277260/

https://www.ncbi.nlm.nih.gov/books/NBK92767/

Japanese Honeysuckle helped me. All other honeysuckle is poisonous.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823622/

High oxalates increase oxidative stress. N-acetycysteine decreases oxalates thus helping with cholesterol homeostasis.

https://www.ncbi.nlm.nih.gov/pubmed/19734276

All these things work because inflammation causes heart disease and they reduce inflammation.

http://www.nejm.org/doi/full/10.1056/NEJMoa1707914

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)32247-X/fulltext

 

 

 

 

My summarized notes.

This is not medical advice I am posting this for educational and informational reason.

I am summarizing my notes. I will update them as I go and make spelling corrections late. Just posting them now to give people an idea what to research.

 

For inflammatory bowel issues and malabsorption issues.

Many with inflammatory bowel have low Catechol-O-Methyltranserase activity. (COMT). Increasing COMT activity must be done with caution if you increase it too much you can swing things too far the other way. Decreased COMPT activity can cause high estrogen levels which effects cholesterol synthesis and can inhibit bile production. If COMT activity is low adrenal hormones will become high and so will more nuero transmitting hormones. Low COMT activity can lead to inflammatory bowel.

SAMe increases COMT activity along with 5-MTHF and folinic acid. Do not take folic acid it will make it worse. Magnesium , lithium and niacin are also needed . Methyl donors are needed for COMT but if a person has sulfation issues they should address it before taking methyl donors.

Those with low COMT need to avoid Quercetin, Rutin, Luteolin, Green Tea, Catechins, Epicatechins, Fisetin, Ferrulic Acid and hydroxytyrosol until they have address the dirty COMT gene. Also L-Dopa compete for COMT so should be avoided.

For a temporary fix reducing tryptophan, phenylalanine, and serotonin reduces high catecholamine levels from low COMT.

These flavonoids can be used by those with COMT down regulation apigenin, genistein, chrysin, myricetin, tangeretin, biacelin, scutellarein and wogonin.

MAO increasing MAO can increase COMT activity. Sirt 1 can activate MAO but is usually high in inflammatory bowel. MAO is not a good route to go because it can cause many other issues.

To address the high adrenal and neurotransmitter levels adaptogenic herbs like eleuthero, ashwanga, passion flower, Lemon balm and valerian will help normalize them.

Increasing progesterone and taking magnesium malate should help also.It will also decrease estrogen levels. Low progesterone can cause problems with sleep causing insomnia or disrupted sleep cycles. It can cause fluid retention and brain fog. It causes estrogen dominance which inhibits T4 from being converted to T3 resulting in low T3 and high T4 levels. Low progesterone can cause night sweats and hot flashes. High adrenaline levels from low COMT activity can cause low progesterone levels.

Cholesterol is needed to produce Progesterone. Stress decreases progesterone. Vitamin C, Magnesium, Zinc, B6, are needed for progesterone. Fiber helps increase it by decreasing bad hormone levels. L-arganine can help increase progesterone.

MTHFR enzyme regulates the methyl cycle issues with it can impair the bodies ability to process folate. It metabolizes folate to 5-methyltetrahydrofolate (5-MTHF). 5-MTHF coverts the ammino acid homocysteine down into methionine and glutathione. Methionine is used to make proteins utilize antioxidants, and assist the liver in processing fats. It also prevents depression and inflammation. Methionine helps convert estradiol into estriol which has weaker estrogen effects. Methionine is farther converted to SAMe which is a methyl donor and reduces inflammation. SAMe supports immune function. SAMe also helps produce certain neurotransmitters such as serotonin, dopamine, and melatonin. SAMe is involved in growth, repair and maintenance of cells.

Methylation has been found to be inhibited in those with inflammatory bowel. Methylation is sometimes referred to as transmethylation. Methylation is when a methyl group is transferred from one compound to another. One example is the recovery of methionine from homocysteine. In order to sustain sufficient reaction rates during metabolic stress this reaction requires B vitamins, B12 and foliate . Mehtyltetrahydrofolate delivers the methyl groups to form the active methyl form of B12. Methycolobalamin is required for themylation of homocysteine.

B12 or folate deficiency causes increased levels of circulating homocysteine. Elevated homocysteine is a risk factor for cardiovascular disease, metabolic syndrome and autism.

Major players in methylation are S-adenosylmethionine (SAMe), and methyltransferase (MT) which include DNA methyltransferase (DNMT), and Protein arginine methyltransferase (PRMT).

Methyltransferases remove methyl group from SAM, thereby converting it to S-adenosyl-L-homocysteine (SAH). This acts as a potent feedback inhibitor of upstream methylation reactions by blocking MT activity. The reactions are reversible.

The ratio of SAM to SAH influences whether SAH is coverted back to SAM or more likely hydrolyzed by S-adenosyl-L-homocysteine hydrolase (SAHase) into andenosine and homocysteine. Blackade of SAHase activity raises intracellular SAH levels and reduces MT activity and indirectly inhibits methylation reactions. Decreased SAHase activity causes raised creatine kinase, SAH, and raised SAM levels. Symptoms are reduced by dietary calorie restriction of methionine and supplementation of creatine and phosphatidylcholine.

Arginine methylation can increase steric hindrance and hydrophobicity but in contrast to phophorylation it does not affect protein charge.

Arginine methylation occurs in histones, trascription factors, cytoskeletal proteins, cytoplasmic signaling proteins and apoptosis proteins.

PRMT substrates are ERA receptor, others are splicing and elongating factors SAP49, UIC, CA150 and FGF-2 and Ewing Sarcoma Oncoprotein.

Problems with the vitamin D receptor can reduce tolerance to methyl donors. Impaired VDR can cause a person to be senstive to methyl donors. SAMe rescues it.

Things that can hinder or block methylation are low electrolytes, and low glutathione. High sulfite levels can cause methyl donor sensitivity. High sulfites can be cause by CBS issues, BH4 causing CBS upregulation or gut dysbiosis. Low superoxide dismutase can also cause methyl donor intolerance or sensitivity. Low methionine can cause methyl donor intolerance. If B12 is not being converted to methylcolobamin it can cause a methyl trap and methyl groups will build up making a person ill.

Homocystein in methylation. In the homocysteine cycle , homocysteine needs to be converted to SAMe and glutathione. SAMe becomes a methyl donor to support healthy methylation and glutathione goes on to act as a powerful antioxidant that slows aging.

Causes of under methylation are leaky gut, nutrient deficiencies especially B12 , low methionine, betaine, choline, and homocysteine levels. The co-factors needed are B12, folate, zinc, B2, B3 and B6.

Mast cell activation syndrome can cause high histamines. Histamines can deplete methyl groups. High basophil levels can cause under methylation. High folate levels can mask B12 deficiency.

Pathways that can lead to undermethylation are CBS, COMT, VDR, MTR, MTRR.

Supporting under methylation SAMe, 5HTP, Evening primrose oil, P5P, inositol, Vitamin A, Vitamin C, Zinc, magnesium, Trymethylglycine (TMG) also known as betaine or DMG. Also using methyl forms of vitamins may help. Folate, methionine, glutathione, natural sources of calcium like stinging nettles. Do not take copper, DMAE or choline. Some say not to take manganese but many are deficient now days and I have not seen reliable sources to show it would be bad to take when an under methylator.

Under methylation can cause many health problems. This is a list of symptoms of under methylation. CBS issues need to be addressed before addressing methylation issues or the methyl donors will have no effect.

Addictive behavior

allergic reactions

anorexia

alzheimers

anxiety

asthma

autism

autoimmunity

bulimia

cancer

chronic degenerative diseases

depression

poor detoxification

fibromyalgia

insomnia

muscle pain

low nuerotransmitters

obesity though lean people can be under methylators also.

Obsessive compulsive disorders

Phobias or fears

PCOS

mental illness

Thyroid dysfunction

Low white blood cell count

Extremely large red blood cells

andrenal fatigue

copper overload

Symptoms of over methylation

headache or migraines

rashes

irritability

increased anxiety

joint pain

muscle pain

insomnia

depression

nausea

seizures

schizophrenia

vomiting

stomach pain

sweating

rashes

hypokalemia low plasma potassium levels.

Heart palpitations

Things that support over methylation are B12, folate, niacinamide, DMAE, choline, manganese, zinc, Omega 3s, DHA and EPA. Vitamin C and E. Avoid SAMe, inositol, TMG or DMG.

Oxidative phosphorylation needs restored in inflammatory bowel. OXPHOS is the final step in cellular respiration. Increasing OXPHOS increases glycolysis. The reduced OXPHOS is a result of inhibition of the citric acid cycle. Oxidative stress can also inhibit OXPHOS. Salicylate (aspirin) causes inhibition of OXPHOS. OXPHOS is used by some cancers for growth. Salicylate inhibits the Krebbs cycle and a-ketoglutarate dehydrogenase. This is dependent on ATP and ADP just as the Krebbs cycle is.

Piperine inhibits OXPHOS so should be avoided if you have issues with it or the Krebbs cycle.

OXPHOS provides the ATP used in the brain for most synaptic events including transmitter release.

In cancer that uses the Warburg effect inducing OXPHOS kills the cancer cell but it can feed other types of cancer. Complex 1 inhibitors induce OXPHOS. This causes a back up of ROS in the cells causing cell destruction so this also shows the importance of homeostasis of OXPHOS. So we should work towards restoring what may be inhibiting it for example low NADPH levels or inhibited function of the citric acid cycle or low ATP.

Need to increase Malic Acid, tamarand, apples, pears grapes, black haw and horsetail herb. Malic acid is needed for the Krebbs cycle, reduces pain, improves fibromyalgia, it prevents kidney stones and kidney disease. It also increase the guts production of GABA.

If they cannot tolerate cold this indicates low SIRT3 levels, this will cause problems with the break down of fats, cause low ATP levels, and low glucose levels. SIRT3 increases Acetyl-CoA which fuels the Krebbs cycle. It also stimulates the Krebbs cycle to produce energy by increasing IDH2 activity which which increases conversion of isocitrate to a-ketoglucarate. This is involved in metabolism of hydroxy proline. SIRT3 is involved in ketogenesis. Low SIRT3 will cause inhibited ketogenesis. Those with inflammatory bowel issues are usually low in SIRT3 . SIRT3 increased NADPH which is usually low in inflammatory bowel and malabsorption. Excess SIRT3 will inhibit protein synthesis in the mitochondria and inhibit oxidative phosphorylation. This is one you would have to be careful in manipulating because many with malabsorption have inhibited OXPHOS. Low SIRT3 levels can lead to NAFLD and COPD it increases fibrosis. SIRT3 increases pyruvate dehydrogenase activity which is usually low in malabsorption disorders but high in some cancers. SIRT3 function is PH dependent so if we have acidosis or alkalosis those must be addressed in order for SIRT3 to function properly. Excess SIRT3 will inhibit bone growth. As with anything homeostasis should be the goal.

Things that increase SIRT3 stimulating HSP70 cold will do that. Exercise, nicotinamide riboside, PQQ, Lipoic Acid, Resveratrol, berberine, bitter melon, green tea, chinese skullcap, Leucine, hydrogen peroxide, carnitine, Kaempferol, caffeic acid, chlorogenic acid.

Ketones and a Ketogenic diet inhibit SIRT3.

NPC1 is inhibited in inflammatory bowel. Which is the cholesterol transporter. A deficiency in NPC1 causes an accumulation of cholesterol in lysosomes. This can also cause a deficiency in enzymes needed to break down fats. This is evident by high fat content in stools. Lecithin increases NPC1 but most have issues that need addressed before they can take lecithin. NPC1 deficiency causes lysosomal acid lipase deficiency this causes a disruption in vitamin A homeostasis because the vitamin A receptor becomes inhibited. SP1 transcription factor and adipocyte protein 2 interact to regulate NPC1. A deficiency in either one will decrease NPC1 activity. AP2 is high in hyperglycemia and diabetes. It is also high in obesity. I suspect that may have to do with lectin issues that can be addressed. Also AP2 has been found to be overexpressed in fibrotic types diseases like COPD and NAFLD. AP2 is increased by cAMP protein kinase. Issues with phosphorylation and dephosphorylation effect the function of AP2. AP2 is also high in diabetes and obesity leading me to believe it is an issue involved with lectin sensitivy or insulin. Studies have shown a possible connection with it and insulin resistance. I also suspect there may be issues with the LXR receptors.

ATOX1 and KPNI issues causes high unbound copper levels. ATOX1 is found in cytoplasma. It binds free metals protecting cells from ROS. It also shuttles copper from cytosol to ATPase transporters. This is vital for the subsequent insertion of copper into ceruloplasmin. It is also involved in cell cycle. When it is inhibited lipogenesis becomes inhibited resulting in cell death from increased oxidative stress. Inhibited bile flow causes a decrease in ATOX1. High C-reactive levels which is common in many tick born illnesses and mycoplasma infections cause these enzymes to become inhibited preventing copper from entering ceruloplasma causing high plasma unbound copper levels.

Low Quinone oxidorecutase levels is very common in inflammatory bowel I suspect the opposite is also true in some people. It is also known as NADH dehydrogenase. It acts on NADH and NADPH. It is involved in the first step of the electron transport chain of OXPHOS. NADH is used to create H2 in order to make ATP. NADH is then oxidized resulting in NAD+. AMP is a quinone oxidoreductase inhibitor. Certain sulfur based herbicides also inhibit Quinone oxidoreductase. Low levels of AMP makes you more susceptible to viral infection. So inhibiting AMP is not a good idea but addressing what may be causing high levels of AMP should be the goal. High levels of adenosine induces sleep and as you sleep adenosine deanimase is produced which degrades adenosine this causes us to awaken. Infection causes raised adenosine levels and they believe the body does this so it can heal. Adenosine increases insulin sensitivity. Adenosine makes the blood brain barrier more porous. Low adenosine causes an increase in dopamine and glutamate. So you can see inhibiting AMP could cause some problems. It is best to increase adenosine deanimase. Adenosine deanimase deficiency has been linked to decreased IL-2 which modeulates the immunes system to help it recognize the difference between something foreign and self. Adenosine deanimase defficiency has also been linked to thymus cell death, lung inflammation and defective T cell receptor signaling.

Zinc deficiency can cause a deficiency in Adenosine deanimase. Estrogen also induces adenosine deanimase so high can most likely cause a depletion of adenosine causing the inability to sleep. Insulin Like Growth Factor 1 also increases Adenosine deanimase. Protein, casein in milk products , calcium, blue berries, resveratrol, vitmain C, cinnamon, prolactin, leucin, magnesium, selenium, astragulus, eleuthero, ursolic acid and carnitine increase adenosine deanimase.

Things that inhibit adenosine deanimase are IL-13 which is high in those with allergies. Berberine and curcumine also inhibit adenosine deaminase. Nitric Oxide also inhibits it. So if you have trouble sleeping using these may help.

ACMSD, SIRT1 and AMPK are high in inflammatory bowel and need decreased.

ACMSD is involved in the metabolism of tryptophan into NAD+. ACMSD is part of the Kynurenine pathway. Amino-B-Carboxymuconate-semiadehyde-decarboxylase limits quinolilinic acid formation by competitive production of picolinic acid. A deficiency in ACMSD can lead to depression and even suicidal behavior.

ACMSD is stimulated by iron (Fe2). Toxins and infections can cause oxidative stress which causes the iron in the body to be converted to Fe3 making it unavailable to the body for use. This can cause iron to build up in the body and become toxic. Lactoferrin and curcumin can restore iron homeostasis. Curcumine if taken too long can cause anemia because it chelates iron so should not be used long term. Lipocalin 2 also restores iron homeostasis. Knotgrass stimulates lipocalin 2.

ACMSD is also stimulated by carbondioxide. (CO2+). There are methods of increasing CO2 levels safely like holding ones breath or breathing into a bag. This should be done with caution because CO2 can cause the body to become more acidic.

A diet high in phytic acid can increase phytol in the body. This can activate PPARa which inhibits ACMSD which causes a rise in blood plasma levels of NAD. But it also increases quinolinic acid which can damage the NMDA receptor and other areas of the brain.

SIRT1 activates and silences many genes that promote health and longevity.

SIRT1 used to be called the anti-aging because it slows aging. In some cancers SIRT1 is elevated. If SIRT1 is activated for too long it will cause oxidative stress. So you can see the importance of SIRT1 homeostasis. Now those who have high SIRT1 levels should not worry about what increases it but should focus on decreasing it because just about everything increases SIRT1. Those with high SIRT1 levels tend to be under weight while those with low levels tend to be overweight. SIRT1 increases as NAD+ levels increase because it requires NAD+ to function. SIRT1 removes acetyl groups off proteins. SIRT1 turns inflammatory genes off. SIRT1 turns the genes off for fat storage and synthesis and the genes for managing blood sugar levels. Acetyl groups are added to groups in response to changes made by inflammation and oxidative stress. SIRT1 can reverse Leptin resistance which is common in obesity. SIRT1 can cause you to be sensitive to T3 which can cause high T4 levels and low T3 levels. This can cause a person to be sensitive to cold. SIRT1 can increase estrogen levels by increasing estrogen receptor signaling. SIRT1 and resveratrol makes you more sensitive to vitamin D. SIRT1 inhibits IGF-1 which is used to build muscle and is crucial for healing. But high levels of IGF-1 can promote cancer. SIRT1 inhibits mTOR which is involved in inflammation and aging. SIRT1 protects us from nitric oxide. Nitric oxide stimulates DNA repair via deacetylation of FOXO1. Without SIRT1 NO would cause cells to self destruct. SIRT1 increases adipopectin which stimulates TH17. High adipopectin has been linked to autoimmunity. High TH17 levels causes inflammatory skin diseases such as Lupus. High TH17 levels causes arthritis which is why high adipopectin levels have been linked to arthritis. Adipopectin stimulates weight loss. SIRT1 decreases NRF2 which is the master regulator of the antioxidant system. Acetylation allows NRF2 to bind to DNA better and as mentioned earlier SIRT1 removes acetyl groups which would inhibit NRF2 binding. SIRT1 decreases pancreatic B-Cell proliferation (growth or production) which can lead to diabetes. GLP-1 which is usually low in inflammatory bowel blocks the effects of SIRT1. Low nicotinamide inceases SIRT1 high doses inhibit it. High SIRT1 levels can impair liver repair.

As stated earlier do not worry about the things that increase SIRT1 because they are numerous but worry about the things that disrupt SIRT1 homeostasis like low GLP-1 levels. This is a list of things that increase SIRT1, NAD+, DHA, Cold, Forskolin, adrenaline by increasing cAMP which increases SIRT1, exersize increases SIRT1, Sunlight increases SIRT1, Fructose , olive oil, zinc, green tea, PQQ, curcumin, pterostilbene, cacitrol, lipoic acid, fisetin, berberine, Pau D Arco which contains Beta Lapachone, Gotu Kola, grape seed extract, Salicylic acid, kelp, quercetin, bitter melon, pyruvate, lycopene, and butein all stimualte SIRT1. Other things that increase SIRT1 are hydrogen peroxide usuall formed from toxins in the body or infections, fasting causes high ketone levels which increases SIRT1, Hydrogen sulfide increases SIRT1 which is produced in gut bacteria when we have gut dysbiosis and by the body. Saunas, malic acid, oxaloacetate, apagenin, Lithium, succinic acid, tryptophan, and aspartic acid which are fuels for NAD+. Those things are raised when we have metabolic issues that need addressed.

Things that increase NAD+ also increase SIRT1

Some things that inhibit SIRT1 are PPAR gamma, melatonin, IGF-1, genistein, and an antibiotic trichostatin. PPAR gamma regualates fatty acid metabolism and glucose homeostasis and has been found to be low in those with inflammatory bowel. Low levels of PPAR causes muscle fatigue. Stimulating the retinoic acid receptors increases PPAR, Honokiol found in magnolia stimulates PPAR gamma . High vitamin D levels prevents PPAR from binding to DNA which would inhibit it’s effects. We do not want to increase PPAR gamma to much because it can lead to acne, fluid and sodium retention. AMPK which is usually high in inflammatory bowel inhibits PPAR gamma. Low PPAR gamma levels makes it difficult to gain weight. Those with low PPAR gamma need more carbohydrates. Cold and nitric oxide can increase PPAR gamma.

Insulin-Like growth factor 1 (IGF-1) also known as Somatomedins and sulfation factor. It is involved in the incorporation of sulfur into cartilage for proper cartilage health. IGF-1 has been found to be low in inflammatory bowel and those with high TH17 levels like lupus. IGF-1 increases antioxidants and decreases inflammation. IGF-1 protects us from autoimmunity. IGF-1 improves memory, acts as an antidepressant and reduces anxiety. IFG-1 restores bone density. IGF-1 improves gut health and nutrient absorption. IGF-1 helps maintain electrolyte balance. High levels of IGF-1 causes acne. Excess IGF-1 causes enlargement of internal organs and excessive bone growth. High levels can lead to diabetes, headaches and blurred vision. It can also cause low sex drive and swelling in limbs.

Things that increase IGF-1 are high calorie intake, protein consumption, casein in milk products, vitamin C, blue berries, growth hormone, cortisol, dhea, parathyroid hormone, prolactin, cinnamon, magnesium, eleuthero, ursolic acid, carnitine, dried plums.

Things that reduce IGF-1 are fasting, protein restriction, royal jelly, glucosamine, berberine, luteolin, curcumin, resveratrol, apagenin, lycopene, green tea, boron, inflammation, and histamines.

AMPK- 5, andenosine monophosphate-activated protein kinase. It plays a role in cellular glucose homeostasis, it is the bodies energy sensor. It activates glucose and fat uptake oxidation in cells when energy is low. It is stimulates fatty acid oxidation and ketogenisis. It inhibits cholesterol synthesis and lipogenesis and trygliceride synthesis , and inhibits adipocyte lipogenesis and inhibits activation of lipolysis. This results in low cholesterol levels with HDL being lower then LDL. This inhibits the breakdown of food into energy. It also inibits protein synthesis leading to many issues especially pheylketonuria. Lypolysis is how our bodies store energy and when inhibited we will have severe weight loss. This takes place in the CBS pathway. High levels of AMPK is common in inflammatory bowel and malabsorption. AMPK is activated by AMP and inhibited by ATP. Hypoglycemia and hypoxia stimulate AMPK. So if we have low glucose levels AMPK will be high causing the CBS pathway to become upregulated which causes high sulfide levels resulting in many health problems and we will start developing a sensitivity to meat and sulfur containing drugs and foods. AMPK levels are low in those with type 2 diabetes and those who are obese. Upregulation of the CBS pathway also causes high hydrogen sulfide levels which can cause low blood pressure and the production of excess free radicals. It also increases nitrosative stress. Excessive weight gain could indicate low AMPK levels excessive weight loss could indicate high AMPK levels. High AMPK levels can result in a lower body temperature. High AMPK levels inhibit PPAR which I discussed earlier. High AMPK levels can make us more prone to viral infections.

Panex Ginseng , green tea, black tea , snow lotus , salicylate and Curcumine should be avoided by those with upregulated CBS or high AMPK levels because these increase AMPK levels. This may help those with type 2 diabetes or obesity because they would increase fat oxidation. S-adenosyl-L-methionine (SAM) inhibits AMPL decreasing the upregulation of the CBS pathway. Nitrosative stress and oxidative stress activate AMPK. Low AMPK levels can cause glycogen storage disease.

Things that increase AMPK are exercise, fasting or calorie restriction, cold exposure increases AMPK. Resverotrol, quercetin, genistein, berberine, curcumin, anthycyanines found in purple fruits, bitter melon, fish oil, carnitine, astragalus, olive oil, creatine, biacalin found in sculletaria, fleabane and plantain herb, fucoiden all stimulate AMPK.

Things that inhibit AMPK are consumption of proteins especially branch chained proteins, high glucose consumption, saturated fat and insulin. For those who have high levels of AMPK it is important to address the cause because the foods that upregulate it are numerous and we cannot avoid them, also they are needed to remain healthy so avoiding them would only add to the problem and prolong our illness. Glucose consumption and increasing ATP will reduce AMPK.

The Krebbs cycle is needed to produce ATP so issues with the Krebbs cycle need addressed. If COMT is low it will lead to issues with the Krebbs cycle and so can low glucose levels. High hydrogen sulfide levels from gut dysbiosis can cause issues with the Krebbs cycle and the CBS pathway. CoQ10 can increase ATP levels. Medium chain fatty acids can increase ATP levels. Glutathion, Vitamin C and vitamin E indirectly increase ATP levels. Cordyceps mushrooms increase ATP levels. Raising ATP levels also improves cognitive function. Pyruvate, cratine and L-carnitine also increase ATP levels. Ribose helps increase ATP production. The B vitamins are needed for ATP production. Magnesium is also needed for ATP production. Strength training improves the bodies ability to produce ATP. Adrenal fatigue can cause low ATP levels. Adaptogenic herbs help restore normal adrenal levels.

Hypoxia, chemicals especially glyphosate and heavy metals can decrease ATP. Dehydration inhibits ATP production so we must stay hydrated with fluoride free water.

Thiol persulfuration is high causing an increase in H2S which can cause inflammation and low blood pressure. This can be caused by frataxin overexpression. This can result in iron accumulation in the cells and increased oxidative stress. P5P, and ubiquinol help.

If you are deficient in flaxatin iron can build up in the cells reducing excess iron in the body and vitamin C help. Curcumine, and lactoferrin can help by reducing iron levels. Curcumin should be used with causion. Taking it for too long can cause anemia. Lipocalin 2 helps restore iron homeostais. Knotgrass stimulates lipocalin 2. It is needed to generate heme groups so we do not want to inhibit frataxin production. We need to focus on reducing oxidative stress and inflammation. HDAC inhibitors increase frataxin. Iron regulatory protein 1 and 2 regulate flaxatin levels. Increased Irp1 and Irp2 expression increases flaxatin. Hepciden regulates Irp1 and Irp2. During infection and inflammation hepcidin increases inhibiting the ability of iron to be absorbed. This causes hypoferremia a type of anemia. It does this to decrease inflammation and to inhibit the pathogens ability to use iron. A hepcidin deficiency can cause iron overload. Though there are no studies on it, it is clear that hepcidin levels can effect thiol persulfuration. So low hepcidin levels would most likely increase persulfuration and high levels would decrease persulfuration. Low levels of iron increase hepcidin and high levels increase hepcicin. High hepciden levels are linked to inflammatory bowel diseases which leads me to believe there is a link to infection that is being overlooked. High hepcidin levels can lead to atheriosclerosis. High hepcidin levels can cause sleep apnea. Hepcidin is high in psoriasis. Low hepcidin levels can increase iron absorption into the body causing iron toxicity.

Things that decrease hepcidin. Vitamin D , STAT3 inhibitors, salicytic acid, Reducing IL-6, alcohol, smoking, testosterone and estrogen.

So if we need to increase heocidin increasing STAT3, IL-6 and other things that cause inflammation should increase hepcidin.

increasing intrinsic factor to improves nutrient absorption especially B12. Gentian root increases intinsic factor. A sign if malabsorption is swelling of the tongue. It is one of the first nutrients to become deficient in malabsorption. Avoid acid blocking drugs. Stomach acid is needed to absorb B12. Increasing stomach acid helps to absorb B12. Apple cider and bitter herbs help increase intrinsic factor. Thyme increases stomach acid. Dandelion and sea salt also promote stomach acid production.

Damage to the gut which is common now because of the BT Toxin and glyphosate in our food causes a loss in intrinci factor production because the pareital cells that generate intrisic factor becomes damaged. Once B12 levels drop it can start a cycle that is hard to break. Sublingual B12 can help , putting it under the tongue can help the body to absorb it. In some the nutrient deficiencies caused may cause issues with converting B12, P5P may be needed also to help with the conversion of B12 to a form the body can use. The B12 deficiency causes inflammation in the gut which farther inhibits nutrient absorption.

We must work on protecting and restoring the mucous membrane for parietal cells to regenerate. Bismuth can help protect the gut permitting it to repair.

Histamine, acetylcholine and gastrin regulate intrinsic factor production. Many are deficient in choline which would inhibit the production of intrinsic factor. Also H2 inhibitors will inhibit histamines which will inhibit production of intrinsic factor.

BHMT (Betaine homocysteine S-methyltransferase is usually low in those with inflammatory bowel but if they have PEMT issues it can cause problems. Betaine taken with pepsin help break down food better and increase gastric acid which should reduce GERD caused by inhibited bile. Hypothyroidism, high estrogen levels, low COMT disrupts hormone levels which can cause low stomach acid levels. Betaine is also know as trymethylglycine or TMG. Betaine increase BHMT levels. Betaine also increases methionine. Vitamin B6 , magnesium and zinc deficiencies can cause low stomach acid levels. Also if you are low in choline needed for neurotransmitters it could slow stomach acid production down. to increase BHMT lysine, choline, creatine, ursodeoxycholic acid, thiamine, mirocholic acid, methylfolate, and methionine are needed. The supplement trymethylglycine also known as TMG is betaine that was extracted from plant sources. Pineapple , beets and golden rod are high in betaine. Betaine, along with glutathione. TMG lowers the burden on the CBS pathway and also helps reduce ammonia levels. It helps the body to recycle phenylalanine preventing it from being converted to ammonia.

PCYT2 inhibition causes weight gain and overexpression can cause weight loss. Low PCYT2 Expression can cause diabetes type 2 and obesity. Phosphate Cytidylyltransferase 2 deficiency causes increased lipid absorption. PCYT2 is found to be common in polycystic fibrosis. PCYT2 deficiency causes a rise in PUFA which causes inflammation. PCYT2 is inhibited by Liver X Receptor activation, vitamin D3 activates the LXR. Oxeysterols also inhibit PCYT2. Oxysterols are cholesterol derivatives.

Leptin causes problems in inflammatory bowel and improving leptin sensitivity is important. Being sensitive to leptins can cause weight loss. Leptin resistance is different it causes obesity. It is important to decrease leptins until the issue is resolved. When you eat leptin it signals that you are full, it lets the brain know to stop eating. High leptin levels will cause the brains letpin receptor to become desensitized to leptin. Processed sugar can desensitize the leptin receptors. When that happens we will keep binge eating. High testosterone and high estrogen levels can cause leptin resistance. High insulin levels can cause leptin resistance. Leptin resistance can cause carbohydrate cravings. Leptin resistance can cause high C-reactive proteins in the body. That causes inflammation and can cause high unbound copper levels in the blood.

High leptin levels can cause osteoperosis and joint damage. Leptin increase metalloproteinase enzymes which cause cell death of the chondrocytes the cells that produce cartilage. High Leptin levels can cause autoimmunity. Leptin resistance also causes elevated free fatty acids.

When functioning properly as we eat and fat levels rise leptin goes up signaling that we have enough calories. When fat levels drop leptin levels go down signaling we need calories. When a person becomes leptin resistant they will feel sluggish because the body tells them to rest to preserve calories because the brain thinks they are starving. Losing weight causes a drop in leptin which will increase hunger. Inflammation, infection, high free fatty acid levels and high leptin levels can cause leptin resistance. This can lead to type 2 diabetes, hypertension, atherosclerosis and insulin resistance. Low melatonin levels can cause this. Studies have shown those who have leptin resistance improve when they get more sunlight. Being deficient in certain gut bacteria can also cause leptin resistance. The gut bacteria that keep us from developing leaky gut and the ones that produce short chain fatty acids prevent leptin resistance. Also health conditions like acidosis and alkalosis can cause changes in FFA levels. Acidosis can reduce FFA levels in the blood. Alkalosis can increase FFA levels. Those with acidosis should not drink alcohol because it increase acidosis. Alcohol consumption causes an increase in acetate which causes the PH of the blood to become more acidic over consumption can cause lacticacidosis.

Things that help with leptin resistance are avoiding processed foods, avoiding consumption of processed sugars including fructose and even processed honey can contribute to it. High T4 levels can cause leptin resistance which could indicate COMT deficiency and high estrogen levels. Honey that is raw does not seem to have these effects. Increasing protein consumption improves leptin sensitivity.

Leptin sensitivity is different, it is caused by leaky gut and causes fatigue, mental illness, skin rashes, allergies, nausea, muscle weakness, numbness and you become more prone to illness. You will also develop gas, bloating, headache, indigestion , diarrhea/constipation and may develop autoimmune or generative disease. Lectins should not be mistaken for Leptin which is different.

This will make you sensitive to nuts, grains, eggs, milk products, legumes, seeds, potatoes, melons, squash and other high lectin foods. Those with lectin sensitivity will usually be underweight but not always. High ketone levels can cause leptin resistance.

Herbs that reduce inflammation and also Omega 3s which help reduce inflammation increases leptin sensitivity. Correcting things that can cause disrupted sleep patterns increases leptin sensitivity. Also addressing infections will improve leptin sensitivity.

Leptin is produced in fats cells in the body. When a person loses weight the fat cells release leptin which makes the body think it is starving. High leptin levels makes us more sensitive to pain. It can also makes us more susceptible to allergies. High leptin levels can cause inflammation.

Phospholipase A needs reduced it is high in inflammatory disease especially inflammatory bowel. High Phospholipase can be caused by infection, toxins like mercury and fluorquinolone injury. Farm chemicals found in our food especially glyphosate can also cause high PLA levels. This leads to leaky gut, gut inflammation, it can eventually lead to many metabolic issues, it can cause arthritis, heart disease, it can damage the liver and pancrease. It can also damage cells and cause cell death.

Those with high PLA levels should avoid Omega 6 fatty acid. PLA increases the fatty acids in the body that causes inflammation and it also increases inflammatory cytokines. It can also increase substance P levels which increase inflammation. It also causes lipids to be oxidized which can prevent the body from being able to properly use fats which are very important for our health. Our brains need fat so it can lead to mental illness. It also causes oxLDL levels to become high.

Some things that inhibit PLA are bitter melon, Omega 3 fatty acids, butyrate found in butter, magnesium, P5P, curcumin, indole, Ginkgo Biloba, Gotu Kola, Ashwangha, Tamarind and natural COX inhibitors reduce PLA.

HSP70 Stimulation helps resolve many issues with inflammatory bowel.

Most with imflammatory bowel need to increase CO2 levels.

Natural calcium channel blockers like hawthorn and magnesium help with inflammatory bowel.

Increasing Ghrelin and motilin improves digestion and gut motilility.

Almost all with inflammatory bowel have high benzoic acid levels and need to reduce it.

Most with inflammatory bowel have high estrogen levels. Inhibiting Sulfatse helps reduce estrogen.

SULTE1 is inhibited and needs increased.

NRF2 activation will increase estrogen sulfotransferase which will decrease estrogen. Selenium is needed.

Chaste berry reduces estrogen and increases progesterone.

Passion Flower is high in chrysin which reduces estrongen but long term use can damage the liver. It also reduces pain and anxiety.

Ellagic Acid reduces estrogen

Maca root restores hormone homeostasis and so does suma root. Kudzu does but should not be used by those with high acetaldehyde levels.

MOGAT3 is disregulated in inflammatory bowel. High levels cause weight gain and low levels cause weight loss.

Heme is usually low in inflammatory bowel but Fe3 levels are usually high. Lactoferrin and curcumin help with this. They restore iron homeostasis but if you take curcumin for to long it can chelate iron from the body causing anemia. Stimulating lipocalin 2 with knotgrass can also restore iron homeostais in the digestive system.

UDP-Glucose is usually low in inflammatory bowel and needs increased.

Many have problems with vitamin D mushrooms have a type of vitamin D the body can easily convert and use and usually will help those who have vitamin D issues.

Oxesterol is usually high in inflammatory bowel.

Cholecystokinin is usually high in inflammatory bowel. Things that reduce CCK are trypsin, capsaicin, amylase, stimulation from cold, calcium channel blockers like magnesium and hawthorn, or calcium chelators.

PKC,Pka, CamK2, cAMP and Calmodulin are low in inflammatory bowel.

T4 is high in inflammatory bowel. Reducing IL1, IL-b, IL-6, TNF-a, and interferon B will reduce T4. Increasing iodotyrosine, deiodinases help recycle thyroid hormones restoring homeostasis. Iodine, selenium and tyrosine are needed. This can cause high B-OHB levels, high ketone levels and can eventually lead to ketoacidosis. This also causes increase in glucokinase. This can cause high Glucose-6-Phosphate levels which will disrupt lipid homeostasis. N-acetylcysteine decreases G6P activity.

High Aspirin and high heperin can cause high T4 and may need reduced.

High T4 levels is usually and indication of high porphyrin levels which can be caused by metabolic issues or high acetaldehyde levels.

Reduce arginine vasopressin if plasma glucose and sodium levels are high increase it if they are low.

Quinolinic acid is high in inflammatory bowel this is caused by tryptophan issues. Tryptophan is needed so we cannot avoid it 5-htp supplement will usually prevent this.

Glycyl-Alanyl-Histidine is usually low and needs increaseased.

Many with inflammatory bowel have high oxalates. Sodium Benzoate used in pickles will increase hippuric acid which reduces oxalates. Also phenolic compound will decrease oxalates these are high in fresh fruit juices.

SLC2bA1 is low in inflammatory bowel. It needs B1, B2, B3, B6, calcium, colbalt,and alpha lipoic acid. Inhibited SLC2bA1 caused poor B6 activity. B1 needs magnesium and manganese. B2 needs ATP and magnesium. B6 needs zinc, lysine, magnesium, thiamine, and niacin.

Most with inflammatory bowel have low methionine synthase levels. This will cause D3 to not be converted and the body will change it and store it instead of using it. This can lead to parathyroid issues.

Most with inflammatory bowel are low in vitamin K2 levels.

Inflammatory bowel causes Alanine glyoxalate and glyoxalate reductase deficiency. These need increased.

P5P stabilizes AGT

Need to get your gut bacteria straightened out it is causing high H2S levels which binds to cytochrome oxidase which slows the metabolism down.

You need to avoid all oils as much as possible and only get medium chain fatty acids like coconut oil and palm oil. Cod liver oil would help also but make sure it contains lemon juice, it usually oxidizes quickly if it doesn’t.

Fulvic acid and humaric acid are the same but the body can more readily use fulvic acid. Continue to use it.

I believe if you supplemented Oxaloacetate it would help your citric acid cycle and bile flow.

Acryl-CoA:cholesterol acetyltranseferase is reduce in inflammatory bowel which effect bile production. It also inhibits function of the Krebbs cycle. Malic acid and B12 are needed to restore ACAT.

Many with inflammatory bowel have SOUX upregulation which upregulates the CBS pathway which leads to high sulfide levels which can inhibit sulfation. Reducing high sulfur goods and getting sulfate a form of sulfur the body can readily use will help. Water from volcanic sources and hot springs are high in sulfates. This can cause low NADH , low ATP levels and low vitamine E levels. It can also deplete malic acid. P5P, molybdenum, manganese, selenium, and magnesium usually help with this. Also soaking in epsom salt and getting 20 minutes of sunlight will help more if you are dark complected.

Inflammatory bowel causes Serine Dehydratase deficiency so it needs increased.

Diglycinate incereases stomach acid levels, it is a type of glycine. Those who have glyoxalate issues may not be able to take this one.

Hexokinase is low in inflammatory bowel. Increasing it helps .

MT-Kinase is low in inflammatory bowel.

GLP-1 is high and GLP-2 is low in inflammatory bowel.

Increasing GIP helps with inflammatory bowel.

DPP4 regulates dipeptidyl peptidase. Upregulating helps with inflammatory bowel. IL-1a increases DDP4 activity. It is also known as fibroblast growth factor.

Protectin 1 is low in inflammatory bowel.

Gycogen synthase is high in inflammatory bowel. Bioavailable copper is needed to reduce it, lithium, zinc, melatonin, curcumin, quercetin, cinnamon, and angelica reduce it.

Stimulating PGC1 helps restore glucose homeostasis. It also stimulates HNF4a. PQQ, curcumin, green tea, vegetables and fresh fruit juice stimulates PGC1.

HNF4 gene regulates TCF7L2. Increasing TCF7L2 improves blood glucose levels, and strengthens intestinal barriers. Most fats inhibit TCF7L2 medium chain fatty acids are required to prevent inhibiting TCF7L2.

Arginine methyltransferases (PRMT) enhances HNF4a. P38 is needed to phophorylate HNF4a.

High Tyrosine Kinase levels inhibit HNF4a.

Inceased cAMP/PKA activity inhibits HNF4a activity.

AMPK inhibits HNF4a.

PGC1a activates HNF4a.

SRC1-3 are steroid receptors. Enhance activity increase HNF4a activity.

Hes6 is a transcriptional factor in HNF4a displaces cofactors of PG1a and CBP from HNF4a. Ketones causes it to become down regulated.

Deficinecy in HNF4a dcreases bilea dn raises T4 levels. Stimulating PXR helps resolve this.

Increasing phosphorylatiohn of FOXO1 by insulin P13K pathway reverses repression of HNF4a via SREBP+FOXO1.

Inflammation and metabolic issues decreases HNF4a.

Increasing SHBG reduces estrogen.

Increasing prohormone convertase 2 enzyme helps restore glucose homeostasis.

Reducing glycetin helps restore gut motility and reduce excess insulin.

High AMPK levels inhibits protein producion and is high in inflammatory bowel.

Oxaloacetate is low in inflammatory bowel witch cause high B-hydroxylbutyrate, it also causes Acetyl-Coa to be shunted towards ketone body production which inhibits histone deacetylase. This also leads to inhibited gluconiogenesis, inhibited urea cycle, inhibited glyoxalate cycle, inhibited bile acid production, inhibited amino acid synthesis and inhibited citric acid cycle.

Increasing NADHP and decreasing NADH increases citrate cynthase and can help restore proper citric acid cycle function.

AGT function is usually inhibited in inflammatory bowel causing high oxalates and inhibited mitochondrial function.

Increasing P5C reductase and Proline oxidase helps with inflammatory bile. They require ornithine.

After the citric acid cycle is functioning increasing Hydroxy Proline Oxidase to help with inflammatory bowel.

KIM1 levels are high in inflammatory bowel which can damage the liver.

All these need increased to help with the many health issues caused by inflammatory bowel. L-Propyl-L-Proline, N-acetyl putrescine proline, taurine, uric acid, L-Pipecolic Acid, L-methionine, N-Acetyl-L-Methionine, 3-Methoxytyrosine, 7-methylguanine, unsaturated fatty acids like decatrienic acid and sebacic acid. Phenylacetic acid and phenylacetyl-glycine need increased.

Nicotinate and nocotinamide are low and need increased.

Need to increase B vitamins using bioavailable forms works best and should be taken with food to prevent a sugar crash and flushing.

Cindoxyl,3-hydroxyquinoline, 3-methyl oxyindole, indoleacryilic acid, indolxylsulfuric acid and xanthurenic acid need increased.

Taurocholic acid needs increased.

Kynurenine needs increased to prevent high quinolone levels.

Taurine needs increased to prevent high ammonia levels, reduce oxidative stress, increase bile flow. Glycine helps for those who do not have glycine issues.

Chondroiton sulfate helps reduce oxalates. I had sulfation issues but it did not seem to raise my sulfide levels.

Need to increase Taurocholic acid and taurodeoxycholic acid.

Need to increase carnitine to improve B-oxidation of fatty acids. This should increase Propionyl-L-carnitine which reduces NOX4 mediated oxidative stress and restore endothelial function.

Need to increase protein metabolism, betaine, bromelain, P5P, magnesium, molybdenum, manganese, cobalt , selenium usually help with that.

Vitamin C needs increased to help with metabolic processes but should be used in moderation in those with inflammatory bowel because to much vitamin C in those with inflammatory bowel can cause excess to convert to oxalates. That is the result of ascorbate 2-sulfate deficiency.

Inhibiting HAO1 prevents excess D-ammino acid activity. It prevents glycolate from being converted to glyoxylate.

Increasing Lactate dehydrogenase reduces oxalate in the renal system.

AGXT (serine-pyruvate aminotransferase) is needed to detox glyoxalate. Marshmallow root increases AGXT.

Increasing Etholamine pretects cells from ROS, restores cellular membrane function and signaling and improves bile flow.

Increasing D-bifunctional protein prevents muscle weakness, seizures, fatty acid accumulation, decreases palmitoyl CoA oxidase, peroxisome thiolase and branch chain acyl-CoA.

Increased phytanic acid oxidase prevents fatty accumulation in the liver. Excess branced chain fatty acids inhibit phytanic acid and cause it to accumulate in the liver which leads to hyperkerotosis. Increasing urea can help with this. This can also lead to adrenoleukodystrophy which causes the enzymes for fatty acid to not to function properly causing very long chain fatty acid build up. This is caused by ABCD1 issues and can result in cerotic build up.

Lorenzo’s oil can correct this conditon. It is 4 parts glyceral trioleate and 1 part glycerol. These are forms of oleic and euric acid made from olive oil and oil from olive seed. If not corrected ti can lead to the accumulation of VLCFA which causes A-Methylacyl-CoA Racemase deficiency. This can cause an accumulation of bile acids. Reducing phytanic and pristanis helps.

Dequaliniun Chloride helps resolve AGT deficiency and AGT misdirection.

By correcting issues causing excess ketone it will reduce acetoacetate, beta-hydroxybutyrate and acetone.

Increasing Pyridine nucleotides improves redox status.

Increasing NADPH oxidase increases SOD. This also blocks inflammatory causing enzymes, reduces cyclogenases and prevents thrombosis.

Increasign Lipoxin A4 decreases inflammation

Increase NADK to improve NAD binding and improve phosphorylation. Magnesium, zinc and CO2 are required.

Reduce PKC to reduce inflammation and gene overexpression.

NADPH oxidase over activation depletes NADPH. Inhibiting it can raise NADPH levels. Tripterygium wolfordii and magnolia inhibit NADPH oxidase. Nitric Oxide also inhibits NADPH oxidase. Gingko biloba inhibits NADPH oxidase but there are studies showing using it for three months or more may damage the liver.

Iron overload decreases NADPH. Lactoferrin, curcumin, and lipocalin 2 help restore iron homeostasis. Taking curcumin for to long can make you anemic because it chelates iron .

Reducing hemolysin prevents thrombosis and fibrosis and reduces H2S. When H2S levels are high it can lead to inflammation and low blood pressure.

Gut bacterias effects on inflammatory bowel.

Those who have inflammatory bowel are defecient in Short chain fatty acids. Akkerinmania municiphila, roseburia intestinalis hominis, inulinivorans faecis ceciola regulates metabolism, produce butyrate and SCFA. They also help restore our beneficial gut bacteria.

Lactobacillus Casei and L Longhum have to be taken together one cannot exist without the other. They keep the antioxidant system at homeostasis and also regulate autophagy.

Lactobacillus reuteri produces folate.

Bacillus infintas reduces inflammatory bowel

Bacillus subtilis produces antibiotics and protects the gut from infection.

Bacillus Clausii prenents diarrhea and reduces inflammatory bowel.

Most with inflammatory bowel have high copper these are some things that may help. This also improves bile flow.

4 ounces of fresh orange juice

¼ teaspoon of sea salt

8 ounces of coconut water

60 mg whole food vitamin C

3 teaspoons of cream of tartar.

For the adrenal fatigue caused by high copper adaptogens like maca root and suma root help. Magnesium, boron, sodium bicarbonate and B vitamins from mushrooms or bee pollen, kelp for iodine and eggs for biotin. Taurine for the liver, molybdenum chelates excess copper. Do not take high doses of vitamin D it inhibits cerruloplasmin raising unbound copper levels. Fluoroquinolones, fluoride, glyphosate can cause high unbound copper levels and will need to be detoxed. Silica helps reduce unbound copper levels.

SULTE1 upregulation improves bile flow and reduces estrogen and reduces high levels of biounavailable copper. Increasing Adenylcyclase also helps.

Increase vitamin K2 to prevent oxalates.

BH4 is needed for proper eNOS function. BH4 inhibits excess gluconeogenisis. AMPK suppresses effects of BH4. High AMPK levels lead to high ketone levels.

GTP (quanosine trisphosphate) is the rate limiting enzyme for BH4 enzyme. Increasing GTP reduces excess succinate in the TCA cycle. Restoring NO bioavailablility and increasing DHFR with folinic acid restores BH4 levels. 5-HTP will also help restore BH4 levels.

A deficiency in BH4 can cause a B12 deficiency.

AMPK Kinase inhibits cholesterol production which negatively impacts bile production, Excess Nitric Oxide activates AMPK Kinase

Fumarate increases oxidative phosphorylation in the Krebbs cycle to reduce ketones, and lactic acid. This will increase adenosine monophosphate.

Cholestasis needs resolved . Increasing bile salts and medium chain fatty acids help and improves bile flow.

Cyclohexancaroxaloic acid, propanoic acid, buranoic acid, decanoic acid and hexanoic acid. Cicetic and Petane. Reduce inflammatory bowel.

NAC and threonine can help.

Allicin reduces acetic acid producing bacteria.

Pantothenic acid cannot function if biotin is low.

If Lipoate is deficient the antioxidant system cannot function.

Biotin requires butyrate and acetate to be absorbed. Low biotin levels causes high B12 levels because your body will be unable to convert it. Brewers yeast and eggs are high in biotin.

Hydroxylase syntase deficiency cause a loss in the ability to metabolize proteins, fats, and carbohydrates. It is dependent on biotin.

When you have inflammatory bowel you have to take nutrients in this order. First biotin, adenosylcobalamin then choline. Then sunflower seeds, mushrooms, small amounts of whole grains, bioavailable forms of B vitamins, and methyl groups.

N-methyl transferase needs increased in those with inflammatory bowel.

N-methylglycine needs increased to prevent psychosis and depression.

Increasing Alkaline Phosphatase increases the guts good bacteria. Cissus Quadrangularis increases it and so does curcumin, cod liver oil, zinc also increase ALP.

ALP stimulates bone growth.

FXR needs stimulated it is inhibited in inflammatory bowel. This corrects cholesterol production, bile production and reduces inflammation.

Motilin needs increased to improve bowel motility and prevent GERD.

Metlatonin needs increased to correct many issues.

Things that may decrease estrogen.

Inhibiting ERa receptor decreases estrogen. Genistien, diadzein, ursolic acid, green tea, kaempferol and narigenin, and phloretin found in apple leaves inhibit ERa. These also reduce Cholecystokinin.

Other things that reduce CCK are ursolic acid found in apple skins and leaves which also contain phloretin which inhibits CCK. Grapes, tomatoes, squash, thyme,rosemary , lettuce, St Johnswort, aloe vera, moringa, elderberries and endive reduce CCK.

Stimulating complement protein C2 reduces estrogen. Cod liver oil, phytoestrogens found in plants, DIM, B12, P5P, Magnesium, and increasing SAMe will increase C2 . It is found a part of the immune system so you do not want to overstimulate it.

To repair cells fructooligosaccarides and glycerophopholipids are needed. Also fructans, pectin, Beta glucans and resistant starches are needed. Many of these can be found in raw milk, clostridium, and whey protein, along with mushrooms and seaweed.

SHBG-sex hormone binding globulin is a protein when found in high levels will cause obesity , type 2 diabetes. Low levels cause hyperthyroidism and autoimmunity. To much SHBG binds up testosterone. SHBG is the master regulator of testosterone and estrogen. High SHBG levels raises estrogen. Low levels will cause hardening of the arteries and inflammation. Low LDL levels and high tryglicerides. High insulin and high prolaction levels. Can raise estrogen and thyroid hormones. High estrogen and high Thyroid hormones increase SHBG.

ABCB4 if inhibited will inhibit bile. ABC proteins transport molecules across membranes. Phosphatidylcholine is it’s substrate. T3 activates ABCB4,

Cyp7a1 inhibition will inhibit key liver bile enzmes. LXR activators increase Cyp7a1. Taurine enhances Cyp7a1 activity.

IBAT inhibition helps with inflammatory bowel. It improves cholestatic pruritus, helps with biliary cholangitis. It also increases ursodeoxycholic acid which increases bile production.

Increased FGF19 increased bile.

Most with inflammatory bowel have a pyruvate carboxylase deficiency. To increase it phosphatydil choline, biotin, chloroacetic acid which is found in asparagus, red algae and seaweed are needed. Also medium chain fatty acids are needed. Thiamine, phosphate, and magnesium are needed. Read apples and cheese also increase it. Triheptanoin also known as C7 will increase it. This helps restore the citric acid cycle function.

Most with inflammatory bowel have disregulated insulin and glucose levels. Bitter melon taken with sinocrassula indica restore insulin levels and glucose homeostasis.

To break down carbohydrates amylase, brush border enzymes, lactase, maltase, isomaltase, and sucrose activity are required.

SGLT1 deficiency with inhibit glucose absorption causing low glucose levels. This can lead to high ketone levels.

Need to correct issues causing SCFA deficiency and need to reduce branch chain amino acids in obesity but increase them in those who are under weight.

It is very important to reduce estrogen because it increases biounavailable copper. Low oxidizers also have high biounavailable copper. Low oxidizers are usually too alkaline.

Things that help with adrenal fatigue caused by high biounavailable copper is meditation, reduce stress, reduce fear, molybdenum, manganese, selenium, B Vitamins, Vitamin C and vitamin E.

Gut dysbiosis and candida can cause high acetaldehde levels. This can cause you to become intoxicated.

Nad-linked aldehyde removes excess acetaldehyde. ALDH2 gene regulates ALDH.

Other enzymes that remove excess acetaldehyde are adehyde oxidase, xanthine oxidase, glyceraldehyde-3-phosphate dehydrogenase oxidises acetaldhyde. Those who have high acetaldehyde should not use Kudzu it raises acetaldehyde levels. Vitamin B1 is also needed to reduce acetaldehyde. Xylitol inhibits bacteria production of acetaldehyde.

Things that can inhibit enzymes that break down acetaldehyde are biogenic amines, noneal, dopamine, noradrenaline, serotonin, and long chain lipid aldehydes.

Cause of flaccid myelitis.

This is not medical advice I am posting this for educational and informational purposes.

addiction-aid-bottle-356054

 

Flaccid myelitits is vaccine injury and should be reported there is a time limit. Vaccine injury of this type takes time to manifest and will start out as allergies or food intolerance. Most medical professionals have no training with vaccines so do not recognize vaccine injury. When it does occur most go to the emergency room and they do not look at a patients vaccine history so they will not make the connection.

It has been a recognized vaccine injury that is awarded in vaccine court.

https://www.mctlawyers.com/vaccine-injury/acute-disseminated-encephalomyelitis-adem/

https://ccandh.com/vaccine-injury/transverse-myelitis-tm-after-vaccination/

There are many documented cases of it.

https://jamanetwork.com/journals/jamaneurology/fullarticle/800879

https://www.ncbi.nlm.nih.gov/pubmed/19880568

https://www.ncbi.nlm.nih.gov/pubmed/22591873

https://www.ncbi.nlm.nih.gov/pubmed/30111741

https://www.ncbi.nlm.nih.gov/pubmed/1554844

https://www.ncbi.nlm.nih.gov/pubmed/19880568

https://www.ncbi.nlm.nih.gov/pubmed/29563955

https://www.ncbi.nlm.nih.gov/pubmed/27847660

https://jamanetwork.com/journals/jamaneurology/fullarticle/800879

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071664/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110068/

www.ncbi.nlm.nih.gov/pubmed/24514081

https://www.jstage.jst.go.jp/article/internalmedicine1992/42/2/42_2_191/_article

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(14)61251-4/fulltext

https://www.ncbi.nlm.nih.gov/pubmed/10210810

www.ncbi.nlm.nih.gov/pmc/articles/PMC3889594/

https://jamanetwork.com/journals/jama/article-abstract/302316

Some vaccine inserts even state flaccid paralysis as a side effect.

http://www.ijcep.com/files/IJCEP1103001.pdf

There is a lot of corruption at the CDC and they contribute to hiding the truth about vaccinations. You have to take it on yourself to be aware of the harm they do.

http://www.robertscottbell.com/producers-corner/some-facts-about-polio-that-the-cdc-wishes-you-didnt-know/

https://thevaccinereaction.org/2016/11/acute-flaccid-myelitis-and-routine-childhood-vaccinations-this-is-nothing-new/#.W7tgXYV_9Sg.facebook

http://lizditz.typepad.com/i_speak_of_dreams/2018/05/18-assertions-about-vaccines-15-diseases-have-been-renamed-after-the-introduction-of-a-vaccine.html

The CDC admitted that vaccines were spreading polio and making it more virulent. Their response was lets declare victory and move on.

https://www.bmj.com/content/344/bmj.e2398/rr/578260

http://ijme.in/articles/polio-programme-let-us-declare-victory-and-move-on/?galley=html

https://www.bmj.com/content/344/bmj.e2398/rr/578260

Vaccinations are harming more then they are helping.

http://medscienceresearch.com/polio/

http://jeffreydachmd.com/wp-content/uploads/2014/12/Suzanne_humphries_dissolving_illusions_disappearance_polio.pdf

Polio vaccine is causing it to become more virulent.

https://jvi.asm.org/content/76/13/6791.short

https://www.alabasterliving.com/blog/what-about-polio

Polio used to be rare until they introduced vaccines for it.

https://academic.oup.com/jid/article/199/3/391/823479

http://healthimpactnews.com/2011/did-vaccines-really-eradicate-polio/

Certain infections like Lyme disease can also cause it but the test has a failure rate of up to 80% so if a person has Lyme their chances of getting properly diagnosed is very slim.

https://academic.oup.com/epirev/article-pdf/22/2/298/6727728/22-2-298.pdf

I did a blog post on identifying vaccine injury.

https://iamajuicer.wordpress.com/2018/07/13/identifying-vaccine-injury-and-its-cost-to-society/

Many drugs can also cause flaccid myelitis especially fluoroquinolones.

https://now.aapmr.org/peripheral-neuropathies-associated-with-drugs-and-toxins/

 

Very good DIY insect repellant.

 

I have read the research on this and it has been shown to work 10 times better then DEET.  When I spray it on no insects bother me. With biting insects carrying so many diseases and the CDC corruption causing Lyme to become epidemic it is a good idea to prevent illness by doing your best to avoid getting bit by any insects.

Make tea with catnip. About a table spoon per cup of water and a pinch of rose mary and cloves . To extent the amount of time it is effective add vanilla.

To make it for plants in the garden which I have used it for that also and it is very effective. Do the above mentioned things and then add the things below.

Smash a few cloves of garlic per gallon of water. Add a pinch of clove per cup of water. It doubles the time it is affective. Add ceyanne pepper. If you use the spray on your person you may want to leave the cayenne pepper out. If you have mold problems I found chelated copper works great. About 1 cap per 2 gallons of water worked great. Works great on people or in the garden. Mugwort also helps prevent mold on plants so you could add some tea made from mugwort to it.

What about those mouth breathers?

David Anderson ran this thread in our Facebook group “Synergistic Illness”. I found it interesting and very informative so I am sharing the links.

We have all seen mouth breathers. When I have seen them I always knew right off the bat they had health problems but there are consequences for breathing through your mouth. This link speaks about the theories surrounding mouth breathing.

https://news.stanford.edu/2018/04/10/paul-ehrlich-problems-modern-jaw/

How it effects our health.

https://www.healthline.com/health/mouth-breathing#symptoms

It can effect your mouth and teeth.

http://kathywinslow.com/myofunctional-therapy

https://www.youtube.com/watch?v=1-U5O7HCt0A&feature=youtu.be

https://www.sciencedaily.com/releases/2010/04/100406125714.htm

Nutrition and mouth breathing.

https://nourishedkitchen.com/the-teeth-tell-the-tale/

http://journeytoforever.org/farm_library/price/price18.html

This can effect you mentally.

https://www.westonaprice.org/health-topics/dentistry/is-it-mental-or-is-it-dental/

https://www.ncbi.nlm.nih.gov/pubmed/18271770

Allergies which can be caused by vaccine injury, toxins, farm chemicals found in our foods and many other things can lead to mouth breathing.

https://www.medicinenet.com/script/main/art.asp?articlekey=115686

https://healthfully.com/350758-symptoms-mouth-breathing.html

https://www.medicalnewstoday.com/articles/319487.php

Some other causes of mouth breathing.

https://www.drstevenlin.com/is-mouth-breathing-bad/

Can’t sleep? Feel disassociated? could be your pineal gland.

 

stock-photo-concept-of-human-intelligence-with-human-brain-on-blue-background-294471983

This is not medical advice, I am posting this for educational and informational purposes.

The pineal gland is involved with many functions in the body including reproduction.

https://www.endocrineweb.com/endocrinology/overview-pineal-gland

http://www.yourhormones.info/glands/pineal-gland/

Problems with the pineal gland can impair our sleep, effect our cognitive abilities, our reaction time, it can effect our judgment and perception of reality. This is why it is very important to detoxify the pineal gland. Problems with the pineal gland can eve effect our hormones.

https://www.healthline.com/health/pineal-gland-function#outlook

https://www.anoasisofhealing.com/pineal-gland-function/

Vitamin A is important for the function of the pineal gland.

https://www.ncbi.nlm.nih.gov/pubmed/24266881

Sunlight stimulates the pineal gland.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679003/

https://www.deepdyve.com/lp/oxford-university-press/how-does-red-light-affect-layer-production-fear-and-stress-SjTQbQVfbh?articleList=%2Fsearch%3Fquery%3Deffect%2Bof%2Blithium%2Bon%2Bthe%2Bmelatonin%2Bproduction%2Bin%2Bthe%2Bpineal%2Bgland%2Bof%26docNotFound%3Dtrue

Lithium can negatively impact the pineal gland.

https://www.tandfonline.com/doi/abs/10.1080/09291010701292086

http://jpet.aspetjournals.org/content/226/3/733

When the pineal gland becomes calcified it detaches us from our enviroment.

https://www.ncbi.nlm.nih.gov/pubmed/1351408

There are things that will help decalcify the pineal gland.

https://www.1800remedies.com/how-to-clean-up-the-pineal-gland/

https://scottjeffrey.com/pineal-gland-detox-supplements/

http://www.stop-being-tired.com/the-dangers-of-pineal-calcification-and-what-you-should-do-about-it

https://myersdetox.com/transcript-166-glyphosate-and-how-to-detox-it-with-dr-stephanie-seneff/

https://www.nature.com/articles/1601287

https://www.myhealthdosage.com/how-to-tell-if-your-pineal-gland-is-calcified/

Melatonin is important for the proper function of the pineal gland.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645767/

Vaccines cause brain damage so you know they are damaging the pineal gland.

https://www.ncbi.nlm.nih.gov/pubmed/23579772

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318414/

There are things that help detox the aluninum from vaccinations.

http://www.greenmedinfo.com/blog/eating-aluminum-it-safe-our-regulators-say

Aluminum and glyphosate work synergistically to damage the pineal gland which can lead to autism.

https://www.scirp.org/journal/PaperInformation.aspx?PaperID=53106

https://janeshealthykitchen.com/avoid-these-foods-with-monsantos-glyphosate/

http://thegoodlylawfulsociety.org/pineal-gland-disrupted-heavy-metals-glyphosate/

EMFs damage the pineal.

https://www.ncbi.nlm.nih.gov/pubmed/23051584

Fluoride damages the pineal gland, it is food in most public water supplies and many bottled waters.

http://www.icnr.com/articles/fluoride-deposition.html

http://www.greenmedinfo.com/blog/fluoride-calcifier-soul

Over consumption of coffee can damage the pineal gland.

https://www.ncbi.nlm.nih.gov/pubmed/30011049

Biology of the pineal gland.

https://www.ncbi.nlm.nih.gov/books/NBK525955/

Working night shift negatively effects the pineal gland.

https://www.ncbi.nlm.nih.gov/pubmed/30230913

DMT a hallucinogen has been shown to protect the brain and pineal gland,. It prevents the degradation of MAO.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088236/

Causes of Obesity and Things That May Help.

This is not medical advice I am posting this for educational and informational purposes.

They blame genetics for obesity. Many things caused by modern medicine and toxins they blame on genetics. Also it is our life styles and eating habits that we inherit from our families that influence our health. If you read some of my post you would see that most things are not genetic as they falsely claim.

They constantly blame genetics but if you do your research you would see that our gut microbiome modulate our genes and if you are lacking a certain microbiota the genes it modulates will be effected. I have posted on it is not your genes but it is your gut and gut microbiome. A change in our microbiome from farm chemicals in our food, BT Toxins from GMOs, antibiotics and other pharmaceuticals and heavy metals can change our gut bacteria. This can result in obesity.

https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-016-0294-z

https://chriskresser.com/9-steps-to-perfect-health-1-dont-eat-toxins/

https://molecularautism.biomedcentral.com/articles/10.1186/s13229-017-0121-4

https://www.aap.org/en-us/about-the-aap/aap-press-room/Pages/AAP-Says-Some-Common-Food-Additives-May-Pose-Health-Risks-to-Children.aspx

To prevent children having a life full of illness it is important to make sure they develop a balanced gut microbiome while young.

https://thevaccinereaction.org/2016/09/role-of-the-microbiome-in-infant-development/

http://www.greenmedinfo.com/article/vaccinated-obese-adults-are-twice-likely-develop-influenza-and-influenza-illne

https://www.omicsonline.org/open-access/vaccine-induced-immune-overload-and-the-resulting-epidemics-of-type-diabetes-and-metabolic-syndrome-1747-0862.S1-025.php?aid=24058

Our environment effects our jeans. Also a childs health is determined by the bacteria they get will still and infant.

https://www.the-scientist.com/news-opinion/environment-not-genetics-primarily-shapes-microbiome-composition-30062

https://www.frontiersin.org/articles/10.3389/fimmu.2014.00427/full

We need to ask ourselves why has obesity , chronic illness and heart disease increased so dramatically? If modern medicine, TV and the government is right then our health should be improving not declining. Studies have shown that we eat far less fat and cholesterol in the U.S. then we did in the past and we eat more fruits and vegetables. So why are these conditions increasing?

http://www.diabetesforecast.org/2012/nov/more-kids-than-ever-have-type-2-diabetes.html?

https://www.selfhacked.com/blog/gut-bacteria-microbiome/?utm_source=ActiveCampaign&utm_medium=email&utm_content=ICES%2FPEMF%2C+Ceylon+Tea%2C+Gut+Microbiome+Affects+%2B+Management%2C+Purple+Sweet+Potato%2C+Myostatin%2C+Hyperbaric+Oxygen+Therapy&utm_campaign=Mar42018+Newsletter

https://www.sciencedaily.com/releases/2015/09/150903131728.htm

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144042

https://onlinelibrary.wiley.com/doi/full/10.1002/oby.20466

https://www.ncbi.nlm.nih.gov/pubmed/21419479

Increasing Leptin sensitivity can reduce body weight.

https://wellnessmama.com/5356/leptin-resistance/

https://medlicker.com/1038-foods-that-increase-leptin-sensitivity

https://universityhealthnews.com/daily/nutrition/how-to-increase-leptin-sensitivity-5-strategies-for-easier-fat-loss/

https://blog.bulletproof.com/how-to-reset-your-leptin-sensitivity-and-master-your-metabolism/

https://www.healthline.com/nutrition/leptin-101

Increasing insulin sensitivity will help with leptin levels.

https://www.marksdailyapple.com/25-ways-to-improve-your-insulin-sensitivity/

https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265866/

Ghrelin can also effect our weight and those who are obese seem to have lower levels of ghrelin but are more sensitive to it. They believe this is because many obese people have been shown to have high cortisol levels. This makes us more sensitive to ghrelin. Rooibos, suma and maca are adaptogenic herbs. Ghrelin, insulin and leptin communicate with each other so issues with those will effect our ghrelin levels.

https://www.healthline.com/nutrition/9-fixes-for-weight-hormones#section4

https://www.selfhacked.com/blog/ghrelin-role-cognitive-gut-function-weight-inflammation-autoimmunity/

https://draxe.com/ghrelin/

Things that effect ghrelin.

https://academic.oup.com/abbs/article/41/3/188/655

https://www.ncbi.nlm.nih.gov/pubmed/29632576

https://www.psychologytoday.com/us/blog/the-athletes-way/201607/vagus-nerve-stimulation-dramatically-reduces-inflammation

Ghrelin regulates our glucose levels in the body and many other things.

https://www.sciencedirect.com/science/article/pii/S2212877815000605

https://www.sciencedirect.com/science/article/pii/S0196978117303844

Often times weight loss can cause a rise in appetite because of the raised Leptin levels. Once leptin levels come down this resolves itself.

https://www.precisionnutrition.com/leptin-ghrelin-weight-loss

Also what contributes to obesity is the low nutrient food and they manipulate advertising to influence what we eat.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743554/

Inflammation and high histamines can cause issues with our cannabinoid receptors and this can lead to diabetes and obesity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839256/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087185/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082307/

https://www.ncbi.nlm.nih.gov/pubmed/26374449

How stress impacts the body and contributes to obesity.

https://robbwolf.com/2012/04/26/diet-stress-biochemistry/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843770/

Diet effects gut bacteria and can cause obesity and diabetes. Food additives are one of the biggest culprits contributing to obesity.

https://www.naturalnews.com/053257_gene_activation_human_development_food_influences.html

https://www.nature.com/articles/nature14232

https://academic.oup.com/jcem/article/101/1/233/2806797

https://www.prnewswire.com/news-releases/mango-and-the-microbiota-new-research-reveals-potential-role-of-this-superfruit-in-maintaining-gut-health-300323541.html

https://www.sciencedaily.com/releases/2015/02/150225132105.htm

https://www.cell.com/cell-reports/fulltext/S2211-1247(17)30751-9

https://drhyman.com/blog/2016/02/18/how-to-fix-your-gut-bacteria-and-lose-weight/#

https://biofoundations.org/increasing-and-maintaining-akkermansia-muciniphila-for-a-healthy-gut-microbiome/

Information about gut microbiome and what they do.

https://www.vitamodularis.org/articles/how_to_interpret_your_microbiome_data.shtml

Microbiota that cause weight loss and weight gain.

https://link.springer.com/article/10.1007%2Fs13167-017-0117-3

How to boost the good gut bacteria.

https://nutritionfacts.org/2013/01/10/boosting-gut-flora-without-probiotics/

Our gut bacteria determines our body type. Remember our gut bacteria modulate our genes and will determine if we are thin or obese based on what the composition of our microbiome is.

http://jlpm.amegroups.com/article/view/3715/4419

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856456/

Vaccines and antibiotics contribute to obesity. Just like anything else obesity is actually an illness. Most who are obese are not obese because they are lazy. I know many obese people who were very hard workers.

https://www.bmj.com/content/345/bmj.e4824/rr/598722

http://www.najms.org/article.asp?issn=1947-2714;year=2016;volume=8;issue=7;spage=297;epage=306;aulast=Geier

https://www.hormonesmatter.com/obesity-childhood-vaccines-blame/

https://sharylattkisson.com/2014/05/14/research-immunologist-sees-vaccine-link-to-autism-obesity-diabetes-in-children/

So we have established obesity can be an autoimmune disorder but it can also be a metablolic disorder.

https://www.wageningenacademic.com/doi/abs/10.3920/BM2016.0184?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239493/

Our diet can contribute to this.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034518/

Antibiotics can cause many health problems including obesity and diabetes.

http://diabetes.diabetesjournals.org/content/57/6/1470

Our gut bacteria modulate our metabolism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925525/

https://www.scientificamerican.com/article/how-gut-bacteria-help-make-us-fat-and-thin/

The sad part is the drugs to counter act the health effects of the first drug causes even more severe health problems.

https://pubs.acs.org/doi/abs/10.1021/pr401230s

Good carbs and bad carbs. Many avoid carbs but our gut bacteria need them to keep us healthy.

https://www.healthline.com/nutrition/good-carbs-bad-carbs#section2

Camu Camu can help with that though. Camu Camu helps reduce stress and inflammation.

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100355

Rose hips helps with obesity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139088/

Eating GMOs causes weight gain by changing our gut bacteria and our metabolism.

https://www.naturalnews.com/045247_GMOs_weight_gain_obesity.html

https://janeshealthykitchen.com/avoid-these-foods-with-monsantos-glyphosate/

http://www.organic-systems.org/journal/92/abstracts/Swanson-et-al.html

https://www.semanticscholar.org/paper/Survey-Reports-Improved-Health-After-Avoiding-Foods-Smith/49b291e5fcfbf0efbfc1eea34a74e99c8cf6fb6e

GMOs, farm chemicals and drugs can effect bile flow which can lead to obesity.

https://www.hindawi.com/journals/jl/2012/754067/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370400/

https://www.researchgate.net/publication/305318376_Glyphosate_pathways_to_modern_diseases_V_Amino_acid_analogue_of_glycine_in_diverse_proteins

http://jem.rupress.org/content/early/2018/01/12/jem.20171965.long

http://www.mdpi.com/1099-4300/15/4/1416

https://www.theunion.com/news/twi/glyphosate-roundup-and-its-link-to-celiac-disease-gluten-intolerance/

All the above mentioned kill our butyrate producing bacteria which keep us from gaining weight.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0117851

Most allergies are caused by farm chemicals in our foods, processed foods, BT Toxin in GMOs cause the body to react the same would your body would if it had food poisoning. This can lead to allergies. Antibiotics kill our good gut bacteria which can lead to allergies. This can result in obesity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318912/

Exposure to heavy metals can lead to obesity by causing inflammation and metabolic issues.

https://www.sciencedaily.com/releases/2016/03/160310155052.htm

Stress, chemicals especially chemicals like glyphosate and glufosinate found in our food can raise zonulin levels. Many medications can raise zonulin levels setting things into motion that can lead to many health problems and obesity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363162/

Lipocalin and obesity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320254/

Lipocalin oxidizes fat causing weight loss.

https://onlinelibrary.wiley.com/doi/full/10.1002/oby.20507

Our gut bacteria need iron tho thrive but the iron they fortify food with is the wrong type. Iron found in curly dock and burdock root will supply you with iron without causing toxicity unless you have certain liver diseases. If you have iron toxicity lactoferrin will restore iron homeostasis. Curcumine will reduce iron levels in the blood also but do not take it too long or you can become anemic.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491036/

Luteolin helps with obesity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490655/

Good vagus nerve health protects from obesity.

https://www.ncbi.nlm.nih.gov/pubmed/25433161

Many of the food manufacturers know processed sugar , processed fructose is even worse and causes inflammation which leads to obesity but they blame the people and hide the fact they new that it has ill effects on our health. I have not included the research in this blog post but processed honey acts pretty much like processed sugar but raw honey does not. Sugars in fruits help fight illness and have health benefits showing that we need the cofactors along with the sugars.

https://well.blogs.nytimes.com/2015/08/09/coca-cola-funds-scientists-who-shift-blame-for-obesity-away-from-bad-diets/

https://academic.oup.com/ajcn/article/84/2/274/4881805

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490579/

I have posted on oxidative stress. It can lead to many health problems including obesity.

https://academic.oup.com/biomedgerontology/advance-article-abstract/doi/10.1093/gerona/glx177/4371617?redirectedFrom=fulltext

Resveratrol found in grape seed extract helps reduce inflammation which is a cause of obesity.

https://www.hindawi.com/journals/omcl/2013/793525/

Sage helps with diabetes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003706/

Vitamin A helps with diabetes and obesity but it and Vitamin D have to be balanced.

https://mcb.asm.org/content/29/12/3286.full

Vitamin D deficiency causes obesity, those with darker complexion are more prone to vitamin D deficiency.

https://www.nature.com/articles/srep10411

Even gut bacteria can positively impact our health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852723/

A list of diet advice by Dr Axe.

https://draxe.com/category/diets-recipes/diets-nutrition-plans/

Diet effects our health by changing our gut bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600934/

https://www.cell.com/cell/fulltext/S0092-8674(15)01481-6

https://www.scientificamerican.com/article/fiber-famished-gut-microbes-linked-to-poor-health1/

Smoking can cause weight gain.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186708

Sulfur is needed by almost every cell in the body. A deficiency or issue with sulfation can cause obesity. I have posted on sulfation.

https://www.westonaprice.org/health-topics/abcs-of-nutrition/sulfur-deficiency/

BH4 is involved in energy metabolism. It is effected by high sulfite levels, inflammation , oxidative stress and nutrient deficiencies. This can lead to obesity. A person with BH4 or CBS issues will be sensitive to sulfur containing foods and drugs.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414566/

Toxins found in our food can cause issues with G6PD especially glyphosate and glufonisate which can lead to obesity.

http://diabetes.diabetesjournals.org/content/55/11/2939

Houttyynia can help with obesity.

https://globalfoodbook.com/benefits-houttuynia-cordata-chameleon-plant

Dandelion helps with diabetes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635758/

The flavonoids found in the white part of citrus fruit helps with obesity.

https://academic.oup.com/advances/article/5/4/404/4568623

Part of the problem is we do not get enough saturated fat now days.

https://www.healthline.com/nutrition/grass-fed-butter-superfood-for-the-heart#section1

https://paleoleap.com/butyrate-anti-inflammatory-fat/

Beta Glucan found in oats, barley and mushrooms help with obesity.

https://www.jfda-online.com/article/S1021-9498(16)30122-3/fulltext

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618555/

We know inflammation can cause diabetes. Endothelins can cause inflammation.

https://www.selfhacked.com/blog/endothelins/?utm_source=ActiveCampaign&utm_medium=email&utm_content=The+Latest+From+SelfHacked&utm_campaign=Jan282018+Newsletter

There are many herbals that will reduce obesity by reducing the things that cause obesity like inflammation, histamines and autoimmune issues or addressing the nutrient deficiencies that can lead to those things.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755736/

Nrf2 activators help with diabetes.

https://www.ncbi.nlm.nih.gov/pubmed/26165427

https://www.ncbi.nlm.nih.gov/pubmed/25672622

Lactoferrin helps with obesity by reducing the gut bacteria that cause obesity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648868/

Spirulina helps with obesity but is high in sulfur for those dealing with sulfur issue they may not be able to use this one.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5274660/

Many spices have healing properties.

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1381-2

Things linked to Alzheimer’s and Chronic Illness.

Amyloid which can be cause by toxins, oxidative stress or inflammation has been linked to both.

https://stanfordhealthcare.org/medical-conditions/blood-heart-circulation/amyloidosis/types/aa-secondary-amyloidosis.html

https://www.nia.nih.gov/health/what-happens-brain-alzheimers-disease

Aluminum found in vaccines and many products like under arm deoderant has been linked to alzheimer’s and chronic illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651828/

https://www.drmcdougall.com/2017/06/30/alzheimers-disease-is-caused-by-chronic-aluminum-poisoning/

https://www.cmsri.org/chronic-illness/

Mercury still used in some vaccines and found in dental fillings can cause both.

http://www.toothbythelake.net/wellness-center/amalgam-fillings/symptoms-of-chronic-mercury-toxicity/

https://dentalwellness4u.com/layperson/symptoms.html

Glyphosate and other farm chemicals found in high levels in our food has been linked to alzheimer’s and chronic illness.

https://www.wellnessresources.com/studies/glyphosate-pathways-to-modern-diseases-iii-manganese-neurological-diseases

Inflammation has been linked to chronic illness and alzheimer’s

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253025/

http://cihr-irsc.gc.ca/e/43625.html

https://www.omicsonline.org/open-access/chronic-diseases-caused-by-chronic-inflammation-require-chronic-treatment-2155-9899.1000238.php?aid=28021

Oxidative stress has been linked to alzheimer’s and chronic illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614697/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840676/

Tick born illness which we know causes chronic illness has been linked to Alzheimer’s along with other infections.

https://www.ncbi.nlm.nih.gov/pubmed/16675154

https://www.ncbi.nlm.nih.gov/pubmed/28294067

So imagine the synergistic effects of all these things.

Things that can cause breast cyst.

Causes of breast cyst.

Infection can cause breast cyst. Many with tick born illness experience this. Even many toxins can cause breast cyst.

https://www.livingnetwork.co.za/drclarknetwork/common-ailments/breast-lumps-pain-sensitivity/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682794/

Infection

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410108/

https://www.ncbi.nlm.nih.gov/pubmed/28866113

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092150/

When we have underlying health issues fibrosis can develop. This is a symptom of a health issue that needs addressed. Excess oxidative stress, metabolic issues and nutrient deficiencies can cause fibrosis among many other things.

https://www.ncbi.nlm.nih.gov/pubmed/28866113

Aluminum found in vaccines and products used on the body can cause cyst.

https://onlinelibrary.wiley.com/doi/abs/10.1002/jat.1384

https://www.ncbi.nlm.nih.gov/pubmed/18785682

https://www.globalhealingcenter.com/natural-health/aluminum-and-breast-cancer/

Clothes that fit too tight.

https://www.ncbi.nlm.nih.gov/pubmed/11938611

Farm chemicals especially glyphosate which has been found to be in most of our food supple can cause breast cyst and even cancer.

https://www.ncbi.nlm.nih.gov/pubmed/23756170

Breast Cyst from an underlying cause.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282604/

Excess oxidative stress from a toxin or illness which can lead to cancer.

https://academic.oup.com/carcin/article/36/10/1121/316266

BPAs and other xenoestrogens we can come in contact with can cause breast cyst.

https://www.ncbi.nlm.nih.gov/pubmed/19933552

Why asthma is rampant now.

 

Many get asthma because of medications changing our gut microbiome, toxins like glyphosate in our foods disrupting out gut microbiome. One the the biggest causes is vaccine injury. We have been taught that many things that keep us healthy are a bad pathogen. When we have all the nutrients we need the supposed pathogens actually help maintain our health. I could not cover anything or this answer would get too long but studies have found receiving immunization naturally protects us from allergies and autoimmunity and receiving it through vaccinations makes us more prone to allergies and autoimmunity. Add all the toxins in our environment and we are asking for trouble.

For example H Pylori reduced our risk of getting asthma.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888205/

Some infection protects us from cancer. Vaccinations have been shown to cause cancer.

http://www.ener-chi.com/articles/how-infection-can-prevent-and-cure-cancer/

Getting chicken pox as a child has been shown to protect from allergies while vaccinations increase the risk for allergies which can lead to asthma.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1399-3038.2011.01224.x

http://erj.ersjournals.com/content/41/2/474.long

Vaccinations increase the risk of asthma and allergies.

https://www.ncbi.nlm.nih.gov/m/pubmed/11513549/

https://ajph.aphapublications.org/doi/full/10.2105/AJPH.2008.138776

Aluminum is toxic to the brain and body. It can cause asthma and is found in many vaccines.

https://www.jacionline.org/article/S0091-6749(15)02364-7/pdf

https://www.tandfonline.com/doi/full/10.3109/1547691X.2012.708366

Vaccinations are also why autoimmune diseases have risen. Vaccine injury is subtle at first and progresses over the years so most do not realize they have been vaccine injured and by the time they have it is too late to be compensated.

http://www.vaccines.net/lupus.htm

https://www.nejm.org/doi/full/10.1056/NEJM195204032461403

http://vaccinechoicecanada.com/in-the-news/evidence-that-food-proteins-in-vaccines-cause-the-development-of-food-allergies/

https://www.ncbi.nlm.nih.gov/pubmed/6335351

Because vaccines cause more harm then good many health professionals are speaking out.

https://www.organiclifestylemagazine.com/doctors-against-vaccines-hear-from-those-who-have-done-the-research

Whether a mother took antibiotics while pregnant or if the baby was born naturaly or through C section can influence their susceptibility of developing asthma.

https://www.naturalnews.com/2017-12-22-c-section-or-antibiotics-while-pregnant-give-babies-probiotics.html

Even over the counter medication increase the risk of asthma. Tylenol has been known to cause liver damage and increase the risk for asthma.

https://www.ncbi.nlm.nih.gov/pubmed/15878691

The CDC has failed at controlling the Lyme epidemic and it makes a person more prone to lung disease. Seems this is a common theme for them and it takes an outside body to figure things out. I honestly do not know what purpose they serve. Usually they are busy covering their mistakes up with someone else figures out how to fix it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898701/

Our gut microbiome protect us from illness. Many toxins in our food disrupt out gut microbiome.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626249/

Breast fed babies have a more diverse gut microbiome which protects them. Many children are formula fed.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674690/

Because antibiotics disrupt our gut bacteria the younger a child is when they receive antibiotics the more prone they are to getting asthma.

https://www.ncbi.nlm.nih.gov/pubmed/28423467

Most know about GMOs and glyphosate and how they contribute to inflammatory bowel disease. This can lead to many illnesses including asthma.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016372/

https://www.naturalnews.com/045247_GMOs_weight_gain_obesity.html

Many have reactions to GMOs while just handling them imagine what they are doing to the body.

https://responsibletechnology.org/genetically-engineered-foods-may-cause-rising-food-allergies-part-two/

https://link.springer.com/chapter/10.1007/978-1-4020-8560-4_16

http://www.i-sis.org.uk/MILTBT.php

Glyphosate causes a list of illnesses that is to long to include here but it has been linked to asthma. Glyphosate has been found to be in most of our food supply.

https://globaljusticeecology.org/glyphosate-causes-changes-to-dna-function-resulting-in-chronic-disease-according-to-study/

Our gut bacteria even influence our brains.

https://www.selfhacked.com/blog/gut-bacteria-microbiome/?utm_source=ActiveCampaign&utm_medium=email&utm_content=ICES%2FPEMF%2C+Ceylon+Tea%2C+Gut+Microbiome+Affects+%2B+Management%2C+Purple+Sweet+Potato%2C+Myostatin%2C+Hyperbaric+Oxygen+Therapy&utm_campaign=Mar42018+Newsletter

Studies have shown that those with low cholesterol live shorter lives and it has a negative impact on their health. Many do not get enough cholesterol.

https://www.sciencedaily.com/releases/2017/06/170601095333.htm

GMOs have been found to contain less nutrients, also glyphosate has been found to be a chelator of minerals and is used on most of the crops grown for our food. Now add this to nutrient depletion from over farming. Nutrient deficiencies contribute to asthma.

https://www.nutraingredients.com/Article/2003/07/11/Mineral-deficiency-could-be-causing-increase-in-asthma

http://www.brainhub.com.au/nutrient-deficiencies-can-play-a-part-in-asthma-and-migraine/

Choline deficiency is very common.

 

This is not medical advice I am posting this for educational and informational purposes.

Many are deficient in choline , it has a dramatic impact on our health.  A deficiency effects everything from digestion to our brain.

Signs of choline deficiencies and sources. Once you read this you will see how choline and betaine deficiency can effect every part of the body even the citric acid cycle.

https://draxe.com/what-is-choline/

When we lose our butyrate producing bacteria it can cause glycogen storage issues. This can effect our ATP levels. We know we can experience dysfunction with choline if ATP levels get low.

https://bmcphysiol.biomedcentral.com/articles/10.1186/1472-6793-8-19

Choline helps with insulin resistance.

http://www.nrcresearchpress.com/doi/abs/10.1139/bcb-2016-0105?journalCode=bcb#.W5MIIR6YXMo

Choline serves so many functions a deficiency in choline has a dramatic whole body especially the liver and the brain.

https://lpi.oregonstate.edu/mic/other-nutrients/choline

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782876/

https://veganhealth.org/choline/

A deficiency in choline also causes high hydrogen peroxide levels. Also oxidative stress can deplete choline.

https://www.ncbi.nlm.nih.gov/pubmed/10783322

https://www.ncbi.nlm.nih.gov/pubmed/19897276

https://mybiohack.com/blog/postural-orthostatic-tachycardia-syndrome-pots-intolerance

The body raises creatine levels to try and protect itself during choline deficiencies.

https://academic.oup.com/ajcn/article/80/1/163/4690274

Bile is important for the digestion of food and nutrient absorption. Choline is needed to produce bile. Our body uses bile to remove many toxins.

https://www.ncbi.nlm.nih.gov/pubmed/9748591

Choline is important for lipid metabolism,the production of VLDL and mitochondrial function.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113756/

https://www.drweil.com/vitamins-supplements-herbs/supplements-remedies/choline/

https://www.physiology.org/doi/full/10.1152/ajpendo.00331.2010

Choline is involved in homocystiene metabolism and issues with methyl-groups can cause homocystenuria.

https://www.sciencedirect.com/science/article/pii/S0014579309001860

https://mostlymeatiswhatieat.blogspot.com/2012/12/homocysteine-and-glutathione-nutrients.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798916/

Bradykinin causes a rise in acetylcholine receptor which is a sign of inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/2842493

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658795/

Transmethylation inhibition raises homocysteine levels and leads to brain damage from inhibiting the bodies ability to metablolize choline. Farm chemicals can inhibit transmethylation especially glyphosate and glufosinate. This can also effect sulfation and the CBS pathways.

https://www.ncbi.nlm.nih.gov/pubmed/18591504

https://chrismasterjohnphd.com/2017/08/12/living-with-mthfr/

https://www.mthfrsupport.com.au/wp-content/uploads/2017/04/PPT-CBS-Pathway-6-slides-per-page.pdf

When this happens bioavialable forms of vitamins will help return things to normal levels.

https://health-boundaries.com/what-is-a-healthy-b12-level/methylcobalamin/

It is important to get the supporting nutrients to properly metabolize and use choline.

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2011.07616.x?

Choline metabolism is just as important as magnesium for our health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601486/

http://geneticgenie.org/blog/2013/10/21/acetylcholine-deficiency-in-chronic-illness-the-hunt-for-the-missing-egg/

https://lpi.oregonstate.edu/mic/other-nutrients/choline

The vagus nerve effects PEMT expression.

https://www.ncbi.nlm.nih.gov/pubmed/25433161

TMAO has been linked to heart disease and is produced mostly by our gut microbiome. It also effects the availability of choline.

https://www.ncbi.nlm.nih.gov/pubmed/21475195

https://mbio.asm.org/content/6/2/e02481-14.full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127123/

DMB found in balsamic vinegar and Wine inhibit TMAO production in our gut microbiome.

https://www.cell.com/cell/fulltext/S0092-8674(15)01574-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867415015743%3Fshowall%3Dtrue

Excessive meat consumption leads to high bacteroides levels. This causes IBD and can lead to cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pubmed/26160437

This can also lead to impaired renal function.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431124/

This can lead to fatty liver disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813164/

Food sources that raise TMAO.

https://www.ncbi.nlm.nih.gov/pubmed/27377678

https://www.selfhacked.com/blog/tmao/

TMAO levels can be reduced with a combination of B vitamins and vitamin D.

https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201600358?

Methyl-group metablolism issues and methy-group donor deficiencies can effect DNA methylation, and gene expression. Remember Choline is a methyl donor and needs the other methyl donors.

https://academic.oup.com/jn/article/132/8/2333S/4687556

Estrogen regulates PEMT expression aberrant estrogen levels can cause liver dysfunction in a situation like this. There are many toxins that can cause this and even vaccine injury can cause this to happen.

https://www.ncbi.nlm.nih.gov/pubmed/21059658

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020773/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430895/

Inflammation, oxidative stress, metabolic issues can cause phospholipase A activity which can cause problems with the gall bladder.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365627/

Aluminum negatively impacts the effects of choline on the brain.

https://www.ncbi.nlm.nih.gov/pubmed/10437134

Folic Acid which is man made has been shown to be linked to cancer, mental illness and even metabolic issues. Folate is natural , but they fortify much of our food with folic acid which is man made. Folic Acid should be avoided it can cause psuedo MTHFR issues.

https://www.ncbi.nlm.nih.gov/pubmed/25733650

Japanese Honeysuckle protects from fatty liver.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632443/

Reduce Basal Ganglia function has been found to be common in those with chronic fatigue syndrome. This can be caused by inflammation, stress, toxins, and autoimmune issues. It is not mentioned in the first study but this is a result of a change in choline levels in the brain. Choline levels become elevated in the brain. This is why it is important to reduce inflammation , learn to deal with stress better and to treat infection. Farm chemicals found in high amounts in our food can also cause this and when possible try to eat organic. Glufosinate a chemical with very similar properties as glyphosate has many of the same ill health effects. Heavy metals can also cause this to happen which are often times found in vaccines.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098156#s5

https://www.nature.com/articles/npp201739

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098156

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/

https://www.e-jnc.org/journal/view.php?number=135

http://amalgam.org/381-2/

https://vaccinepapers.org/wp-content/uploads/ganrot-aluminum-health-effects1986.pdf

All the above mentioned things can effect BCHE and ACHE levels which are known to be high in multiple sclerosis. Farm chemicals have been shown to reduce BCHE which is important for ACHE homeostasis. High BCHE levels can cause myocardial infarction. BCHE levels is found to be high in obestiy, uremia, hyperthyroidism, and hypertension. Those are all inflammatory dieses. BCHE is elevated during inflammation. This shows the importance of addressing things that cause inflammation.

BCHE levels is low in liver disease and cancer. Low BCHE levels are a sign of malnutrition. Low BCHE levels can cause higher ACHE levels. High ACHE levels can cause mental illness.

https://www.nature.com/articles/s41598-018-19701-7

https://www.ncbi.nlm.nih.gov/pubmed/10794391

BCHE levels decline in malnutrition.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581611/

Ghrelin is involved in glucose and insulin homeostasis. BCHE regulates Ghrelin levels I have posted on Ghrelin and it’s involvement in glucose and insulin homeostasis. BCHE reduces Ghrelin.

https://www.nature.com/articles/ijo2017123

Information how various things effect ACHE and BCHE.

http://turkjbiochem.com/2003/054_061.pdf

Autoimmunity can effect choline status and lead to chronic illness. I have posted about autoimmunity and how to correct it. Myasthemia Gravis is caused by autoantibodies detroying, altering or inhibiting the acetylcholine receptors. Most of the things I have mentioned in my post on autoimmunity that can cause these issues.

https://www.drweil.com/health-wellness/body-mind-spirit/autoimmune-disorders/myasthenia-gravis/

http://www.lifeextension.com/Protocols/Neurological/Myasthenia-Gravis/Page-01

Choline is important in the production of VLDL which has been found to be low in those with inflammatory bowel disorders. Inflammation and autoimmune issues can cause low VLDL levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241147/

https://www.hindawi.com/journals/mi/2016/1363818/

https://www.selfhacked.com/blog/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections/

This is why phosphatidylcholine (Lecithin). Helps with inflammatory bowel disorders. Most of my friends said that sun flower seed oil is the most effective.

https://www.ncbi.nlm.nih.gov/pubmed/20926877

Antiphospholipid syndrome which leads to excessive blood clotting can is tied to choline metabolism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112255/

Metabolic issues can effect choline status which can lead to POTS.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415014/

https://mcb.asm.org/content/30/7/1746

Activation of a7 nicotinic acetycholine receptors in the presence of choline helps with Alzheimers and mental illness by enhancing glutamate release.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112255/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600449/

Our gut bacteria effect the status of our choline levels.

https://genomemedicine.biomedcentral.com/track/pdf/10.1186/gm228

High Leptin levels can cause cardiovascular disease and low leptin levels can lead to obesity. I have covered leptin in previous post.

http://www.yourhormones.info/hormones/leptin/

https://www.selfhacked.com/blog/the-root-causes-of-leptin-resistance-and-12-ways-to-reverse-it/

An increase in Dgat1 causes fatty liver disease. Betaine and choline prevents fatty liver by inhibiting Dagat1.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097135/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647077/

https://www.frontiersin.org/articles/10.3389/fnut.2018.00061/full

https://atrium.lib.uoguelph.ca/xmlui/bitstream/handle/10214/4975/Sivanesan_Sugashan_201212_Msc.pdf;sequence=3

Betaine and choline help restore many of the metabolic pathways involved in the metabolism of choline.

https://www.frontiersin.org/articles/10.3389/fnut.2018.00061/full

http://www.nrcresearchpress.com/doi/full/10.1139/bcb-2016-0105

Betaine helps maintain the citric acid enzymes.

http://jhs.pharm.or.jp/data/53(6)/53_671.pdf

Phosphatidylcholine which is responsible for cell membrane integrity is regulated by cytidylyltranssfrerase.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5936825/

How I Started healing and correcting my methylation issues and my BH4 enzyme deficiency.

 

 

 

 

This is not medical advice I am posting this for informational and educational purposes.

These are the things I did that got me headed in the right direction to healing. Many things like autoimmune issues, sulfation, detoxing from GMOs and even herb information I have covered in other post. This is to show people the things I did that got me started on the path to healing. Homeostasis is the goal once you start feeling better and can eat the foods that contain certain nutrients I stopped taking the nutrient and only took maintenance doses to make sure levels did not get low. If you continue to take things after you have corrected certain health issues you can push things to far the other way for example I had high ammonia levels. I pushed things too far the other way and developed acidosis.

I am trying to put a list together of things that helped me the most. For example I had so many metabolic issues that choline was causing me a lot of problems. I would get indigestion if I ate anything with choline in it. It is very important to address issues causing us to not be able to break down proteins because the body needs choline for many metabolic pathways. The choline issues is because of the high phenylalanine levels and I was not recycling it properly so ammonia was getting produced that caused me to have high ammonia levels especially if I consumed things that had animal flesh because it is high in phenylalanine. Potatoes are another thing that was high in Phenylalanine. This can indicate MTHFR enzyme issues which can lead to BH4 issues. This can lead to endogenous oxalates being produced from the other downstream metabolic pathways that are effected. It usually leads to high insulin levels which causes low glucose levels. It also leads to the mitochondria pretty much shutting down so no nutrients are being exchanged and your cells cannot detox. Folic Acid is man made and added to our food. It causes a lot of health issues because it build up in our blood and can negative impact the NMDA receptor in the brain and it inhibits MTHFR enzymes and BH4 enzymes. So I would avoid processed foods because once those enzymes shut down you will become deficient in nutrients because you will be unable to absorb them. You will lose your ability to produce short chain fatty acids from the loss of gut bacteria and enzymes needed to produce them. You also will lose the ability of your body to produce the fats it needs. BH4 helps in the creation of our feel good hormones and the hormone we need for restful sleep. When we are deficient in it we will experience anxiety, indecisiveness and we may display high risk behavior and difficulty sleeping. We become deficient in tryptophan. Many had good results with 5-HTP which is a type of tryptophan that does not need to be metabolized for the body to use it. Once things get working right we need tryptophan for our good gut microbes to get established. BH4 is needed to produce and use the ammino acids throughout the body. Oxalates can be produced in a few different ways if we are deficient in BH4 enzymes and we may develop phylketonuria it can also lead to issues with pyrroles.

Many of my friends would take methotrexate and they would feel good at first and then get worse because it inhibits MTHFR and BH4 enzymes.

Fluoride , chlorinated water and fluoroquinolones can also inhibit these enzymes.

I was so ill I would even throw water up and I have very good quality well water. I struggled to get the nutrients I needed in my body. To prevent nausea I had to put parsley, nutmeg, ginger or clove in my teas to settle my stomach.

Each person is different but these are the basics of things that helped the most people. Please do your research and make sure it is safe for you to use the things I mention. The only animal protein I was able to consume was white fleshed fish except blue fish. I reacted very bad to blue fish.

My gut was a wreck from not knowing how toxic GMOs were, I have posted them and how the effect the body especially the gut. Now add all that to having tick born illness and things good bad very quickly. No matter how ill you are if you plan your protocol and take notes on your health, on how various foods effect you, on how you are effected by your environment it can help you develop a protocol unique to you that is more directed at your healing because each of us are unique.

Because we need protein and I could not eat many proteins I used bee pollen, why protein which you have to watch many of them and proteins to them and you especially have to watch that they did not add phenylalanine. The other proteins it is best to make sure they have and L in front of them for example L-Tyrosine that means it is bioavailable to the body. When you have BH4 or MTHFR enzyme issues you will usually need L-tyrosine, L-valine, L-leucine, L-threonine, L-Serine and L-arganine. If you are under a lot of oxidative stress then you may want to hold off on L-arginine until you get it under control. I posted on oxidative stress and the antioxidant system.

Beta Glucan found in organic oatmeal and mushrooms helps also. Some have had good results with taurine especially those of my friends who were vegetarians.

Other minerals needed downstream that can effect these enzymes are manganese and molybdenum. I took them until I started to feel better then I cut back to three times a week because if levels get too high they can become toxic.

To help my gut bacteria get established I used grape fruit seed extract 2 days then waited a week because it inhibits Cytochrome P450 enzymes needed detox drugs and other chemicals. It should never be used when taking medications. I also took Pepto Bismo because it helps fight the bad bacteria in the gut and it helps fight many pathogens. It takes a very high level of Bismuth to be toxic.

I do know often times when a metabolic or detox pathway opened up and started working correctly all heck would break lose for a few days and I even felt pain. Especially when I started detoxing oxalates , I dumped so many so fast that my bladder took a bad hit and hurt for a while and the pain of urinating them out was almost beyond what I could bare because it is like peeing little pieces of glass out.

Then as the bad bacteria died off and my good started getting established my intestines detoxed. I was excreting some pretty scary things. Slime that was shaped like my intestine, dead intestinal tissues and the fiber that had not moved through my body but was sitting in my digestive tract. I t looked like worms and I thought I had parasites. I thought I was defecating part of my intestines out because often times the slime would come out shaped like my intestine. Also our body uses bile to detox some things like copper so diatomateous and psyllium husk helps with that, also inulin helps because the body will attach the toxins to fiber to be excreted. I was so full of toxins that this took a month to resolve. I found grape seed extract, bacopa, butchers broom and many claim hawthorne help prevent hemorrhoids. I learned that after the fact but the really helped reduce my hemorroids. I would only take the psyllium a few times a week because it can over feed the good gut bacteria and cause dysbiosis.

I have posted on the various gut bacteria and what they do. The gut bacteria that produce our feel good hormones need butyrate to thrive. They also produce it themselves and it helps establish the other good bacteria. Good sources of butyrate is raw milk, butter and ghee.

I had to slowly reintroduce fruit back into my diet. It would take me a week to eat and apple. But I would slowly increase the amount of the fruit I would eat and my good gut bacteria slowly started to reestablish.

I still limit my meat intake because it causes high bacteroides levels which is the cause of most types of inflammatory bowel diseases. Those who get constipated often should avoid meat because it alkalizes the digestive system which causes bacteroides to get into the upper part of the digestive tract and will cause the muscles of the bowels to become paralyzed. The cycle they cause can be broken but takes a lot of work and planning and constant protocol adjustments.

I tried my best to get my nutrients from natural sources once I got my digestive tract working.

The vitamins that we are usually deficient is are:

B12 I found methylcolbalamin seem to work the best for most.

B12 needs vitamin B6 to convert to a form the body can use. Most had the best results with Pyridoxine Phosphate (P5P).

MTHFR and BH4 enzymes need folate not to be mistaken for toxic folic acid. It cannot function without B6 and B2 (riboflavin) .

Most with these health issues are deficient in vitamins D, E, A and K2 which are mostly oil soluble so should be taken when you take an oil. Sun Flower lecithen also helps with the enzymes we need and would be an oil we could take them with along with something that contains butyrate because butyrate increases nutrient absorption. You do not want to take too much K2 or any of the other vitamins. Homeostasis is the goal once things start working again you want to back of and let things balance out. High doses of vitamin D can cause oxalates so I only took about 4000 IU about three or four times a week. Coconut oil is another oil that is good to use. It has monolauren which heals the brain and kills many pathogens. Olive oil is good to use because it is an Nrf2 activator which helps with oxidative stress.

N-Acetylcysteine (NAC) helped me a lot, I only took it about three times a week. I found that most studies I read the most benefits were in limiting the number of times it is taken a week. If consumed too much you seem to lose the benefits and make yourself prone to illness.

Betaine (trimethylglycine, or TMG) helped with my digestive issues and helps reduce ammonia levels from the metabolic issues. They also help reduce bad gut bacteria and increase the good.

The proteins we need should be in the form that has an L in front of them which indicates they are bioavailable so the body doesn’t have to convert them. The proteins that most have benefited form are L-tyrosine, L-Valine, L-Lysine, L-threonine and L-Arginine. L-arginine is used by BH4 to produce Nitric Oxide to regulate our blood pressure.

Many appear to be low in iron but actually are high in a type of iron the body cannot use and it inhibits absorption of the good iron. Lactoferrin or colostrum will hell reduce the bad iron and restore iron homeostasis. Curcumin chelates iron from the body but if take too long it can make you anemic.

Many of use develop sulfation issues which I have posted on. So for a short period of time will as we address the causes like gut dysbiosis , heavy metal toxicity or high farm chemical levels like glyphosate it helps to avoid high sulfur foods like cruciferous vegetables, onions and garlic. If our sulfide levels get too high they will interfere with many metabolic pathways. With the nutrient deficiencies they do not get recycled and converted to the good sulfates which we need. Also if we have gut bacteria imbalance high sulfide levels will occurs. Once our metabolic pathways are working our sulfide levels will come down. This will help reduce our hormone levels.

For detoxing I alternated between dandelion, curly dock, rooibos, sumac , curly dock, burdock, and chamomille so I would use different liver enzymes and would not end of depleting certain ones. Most spices are great for detoxing but you have to watch thyme and rosemary they raise white blood cell count and have been know to raise them too high if taken for too long or in to high a dose. I also used raw honey in lemon juice in the morning to help with glucose levels and to provide zinc to my body. Lemon helps detox the body including the toxins produced by regular body function. Honey also contains pectin which helps the good gut bacteria to get established.

Biotin, selenium and Boron are great for detoxing heavy metals. Selenium can help with sleep. Iodine helps with detoxing heavy metals but if taken in excessive amounts it can damage the thyroids so I got mine from seaweed , also I could eat shrimp and lobster without getting ill.

The fruits and vegetables that seem to help me the most was pistachios, walnuts, hickory nuts and pecans. Green peppers really helped , carrot leaves, celery leaves or celery, bananas. I noticed the very ripe bananas and the under ripe ones I reacted to. I could only eat the bananas that were just ripe to were they had just turned yellow with no green but were still a little firm. Pineapple helped me a lot but the only one I could eat was the ones that had turned dark yellow and were close to turning red and fermenting. I had to ease into fruits and vegetables and slowly work into eating them and slowly add new ones until my gut bacteria got established. I also had to do the same thing with dairy products. I found once I got my mast cell activation syndrome under control fermented dairy like butter milk, kefir, and cheeses help me get over my dairy intolerance. Once I got my leaky gut healed I was no longer sensitive to gluten and gliadin. If you have issues with it, it is a sign of a deficiency in gut bacteria or leaky gut.

We are usually deficient in magnesium. I alternated between magnesium chloride and magnesium citrate. I took the magnesium citrate about three times a week at first then I backed of to twice a week. Citrated is recycled by the body. If levels get too high it can cause liver problems and start to damage the red blood cells. Once I got my oxalate levels down I stopped taking the magnesium citrate. I took magnesium later in the day because it helps you sleep.

Herbs that helped me relax and sleep better were rooibos, camu camu (amla fruit), angelica, mugwort or wormwood they are chemically similar. I also used yarrow in the morning it energizes you and reduces pain. Most of what I just mentioned raise GABA levels. Pau D Arco also raises GABA levels. Gingko Biloba raises GABA levels but gave me a headache the first few times I took it. After that I actually could feel my mind thinking clearer. It should not be taken too long studies have shown after about three months it starts to damage the liver.

Exercise even yoga increases BH4 enzyme levels. Vitamin C increases BH4 levels but man made ascorbic acid has been shown to cause oxalates. If you take vitamin C in high doses it can break down red blood cells. The only sources of vitamin C that did not bother me when my oxalates where high was green peppers, camu camu (amla fruit) and sumac.

We need sunlight to produce vitamin D but getting sun burned can inhibit BH4 enzymes.

We may develop high copper levels because our bodies get rid of excessive copper through our bile. If our digestive tract is not working right and we are having difficulty getting enough fiber then we will absorb the reabsorb the bile back into our system with the toxins still in it because fiber and our gut bacteria detox the bile for us. If this happens we should avoid colloidal silver because it can inhibit our bodies ability to use the copper.

Baking soda (sodium bicarbonate) helps detox many things from the body. It provide the bicarbonate the body needs to regulate PH balance and provide molecules needed to produce stomach acid. I would drink a cup with a tablespoon of baking soda in it three times a week. I would sip on it throughout the day. Increased iron can help reduce copper. Too much vitamin D stop production of cerruloplasm needed for the regulation of copper. Usually I do not suggest taking too much molybdenum but it will reduce copper levels. If copper is not high I only take it three times a week. Silica also helps get our copper levels down and is needed for bone growth and repair.

Pyrroloquinoline Quinone helps feed the good gut bacteria and restore balance, heals nerves and has many other healy qualities.

CoQ10 helped with my energy levels. I got the kind you dissolve under your tongue because I did not seem to notice any benefits to the once you consumed.

Nicacin is needed to produce NAD. Tryptophan is also needed.

To help with my adrenal fatigue I used maca root, suma root and kudzu.

To help heal my gut I used plantain herb, liquid aloe vera gel and oatmeal for the beta glucan. Then when I addressed my metabolic issues I added bone broth. Those who do not consume animal products may be able to use arrow root it helped me. Black seed oil is amazing and heals just about everything. Toxifolin also known as isoquerciten is great for all around healing. It is found in milk thistle.

When I was in pain I used opium lettuce and california poppy.

Avoid Folic Acid it is man made and toxic to the body especially the NMDA receptor and it can cause a deficiency in MTHFR and BH4 enzymes.

folate deficiency cause a loss of MTHFR enzyme which will deplete BH4 enzyme.

https://www.ncbi.nlm.nih.gov/pubmed/9462523

This study says Folic Acid helps recycle BH2. I think they meant Folate because folic acid depletes MTHFR which causes a decrease in BH4.

https://www.ncbi.nlm.nih.gov/pubmed/26414244

Genes are they permanently written?

Bdna_cropped

 

This is not medical advice I am posting this for informational and educational purposes.

If you have read my post on your gut and gut microbiome you know by now it is the microbes in your gut that influence your genes more then inherited genetics. You can turn genes off and on to correct problem genes. This is known as epigenetics. There are many things that can cause negative epigenetic changes. Stress, toxins, glyphosate breaks the glycine cleavage system in the body causing many negative epigenetic changes. Heavy metals and even the lifestyles we choose like drug abuse, alcohol abuse or smoking. These epigenetic changes can be passed to children. But many of these things can be corrected. I have discussed many things surround this like addressing acidosis, oxidative stress, and correcting metabolic issues which helps our bodies to correct gene issues we may be having. Since our gut microbiome regulate gene expression it is very important to learn the microbiota that modulate or regulate those genes.

https://leviquackenboss.wordpress.com/2016/06/13/you-dont-have-bad-genes/

http://reset.me/story/epigenetics-how-you-can-change-your-genes-and-change-your-life/

https://www.telegraph.co.uk/news/science/10369861/Epigenetics-How-to-alter-your-genes.html

The microbes in our gut modulates our genes. That is why pharmaceuticals , farm chemicals found in our food and toxins in our environment have such an impact on our genes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583657/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572264/

Stress can cause epigenetic changes that get passed to children.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021821/

https://www.nature.com/articles/mp201735

Meaningful meditation can cause positive epigenetic changes.

https://www.psychologytoday.com/us/blog/the-athletes-way/201312/meditation-has-the-power-influence-your-genes

https://www.whatisepigenetics.com/3-epigenetic-reasons-to-meditate-your-stress-away/

https://eocinstitute.org/meditation/epigenetics-how-meditation-upgrades-gene-expression-slows-cancer/

Many things can effect autophagy which helps to maintain gene integrity. It is very important to correct any metabolic issues because they have negative effects autophagy.

https://www.sciencedirect.com/science/article/pii/S109727651630870X

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103355/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811684/

Even exercise causes positive epigenetic changes.

https://www.ncbi.nlm.nih.gov/pubmed/28624982

Even yoga promotes positive epigenetic changes.

https://www.ncbi.nlm.nih.gov/pubmed/27898068

Hacking our environment hacks our genes.

https://medium.com/thrive-global/we-are-not-our-genes-and-the-power-of-epigenetics-b8eedb09a5e7

https://www.sciencedaily.com/releases/2005/10/051026090636.htm

Vaccinations are known to cause negative epigenetic changes that is why the vaccine manufacturers are protected from the liability of vaccine injuries and death. Most medical professionals are not trains to identify and report vaccine injury that is why the government stated only about 10% of vaccine injuries are reported.

https://www.vaccineinjury.info/vaccinations-in-general/vaccines-and-immune-system.html

then you get people like this who believe genetics are hard wired and will blame vaccine injury on genetics even though the toxins found in vaccines have been shown to cause negative epigenetic changes.

https://metabolichealing.com/genetic-variants-that-may-cause-vaccine-injury/

Dr. Ben Lynch states it best when he says we cause our genes to become dirty. Once that happens it is a long road back but we can fix them.

https://www.drbenlynch.com/vaccinesdirtygene/

Once our genes get dirty we develop excess oxidative stress which increase the rate of the negative epigenetic changes. I have posted on oxidative stress.

https://www.hindawi.com/journals/omcl/2017/9175806/

Glyphosate which has been found to be high in our food supply and water supplies has been shown to dirty our genes up. So it is very important to detox it and other toxins.

https://www.ncbi.nlm.nih.gov/pubmed/28351773

If your genes get dirty it is a long road back to recovery because you will have to become your own researcher because how to reprogram the genes is just now being researched and the information on doing it safely is scarce. Your best bet is to hope you meet some people who have been there and figured things out and are willing to share what helped them.

https://academic.oup.com/hmg/article/14/suppl_1/R47/560895

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359361/

The microbes that help heal the gut.

 

This is not medical advice I am posting this for informational and educational purposes.

Most with inflammatory bowel disease have too many bacteriodes which is caused by excess meat consumption, antibiotics, glyphosate, glufosinate and other farm chemicals. This results in nutrient deficiencies which lead to metabolic and gene problems. Before you can get your gut bacteria reestablished you have to address those health issues because our gut microbes communicate with and modulate our genes. These are the bacteria that was found to help restore intestinal health in those with inflammatory bowel disease or leaky gut. They also help those with autoimmune issues and chronic illness.

Studies have shown that by alternating probiotics and taking lower doses of them and taking a break from them to leave them balance out is more effective at establishing a balance of our gut bacteria.

Each of our triggers are different so it is important to keep a food diary on how various food effects you.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021001/

Our gut bacteria modulate our genes. So an imbalance in them or a deficiency has effects on our genes,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915727/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892391/

We need a diversity in our gut bacteria for them to stay established.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107516/

A loss of short chain fatty acid and butyrate producing bacteria cause inflammatory bowel disease and constipation.

https://jcm.asm.org/content/52/2/398

Our diets influence out gut bacteria for example meat alkalizes the gut producing an environment that will permit the rise of certain bacteria that can lead to health problems. If we consume too much meat it can lead to inflammatory bowel diseases because it raises bacteroides levels and kills the bacteria that produce the good fats we need and the short chain fatty acids the body needs. High bacteroides levels can also lead to heart disease, diabetes, and even autoimmunity. Also a diet high in meat can increase the bacteria in our guts that cause inflammation.

Transfats and oils like vegetable oil and canola oil were found to raise bacteroides levels and decrease our good short chain fatty acid producing bacteria. Oils like olive oil, coconut oil and fish oil have been found to promote good gut bacteria.

Whey protein and the glycoproteins found in mushrooms have been found to reduce bacteroides and increase the good gut bacteria.

Lactose has been found to increase the good bacteria that helps produce butyrate and short chain fatty acids. This is why it is important to address lactose intolerance, it can be corrected.

Sugar increases Bifidobacterium, this could be bad for those who are over weight but good for those who are under weight and need to gain weight.

Prebiotics like resistant starch, oligosaccharides, fructosaccharides increase our short chain fatty acid producing bacteria. Short chain fatty acids are very important keeping us healthy. They have also been found to increase the microbes that protect and strengthen the health of our digestive system.

Polyphenols found in fruit especially berries, promote good bacteria while reducing the bad.

Artificial sweeteners especially aspartame has been shown to increase bacteroides to the point it could lead to irritable bowel syndrome.

https://www.hyperbiotics.com/blogs/recent-articles/89735302-your-diet-changes-your-microbiome-fast

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1175-y

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417592/

A list of foods that increase our good gut bacteria.

https://cfsremission.com/2017/08/24/food-to-increase-bifidobacteria-and-lactobacillus/

In order to establish our good bacteria we need FOMAPs I found introducing them very slowly worked best for me as my gut bacteria received the food they needed and increased I could increase my FODMAP intake. If we stay on a FODMAP diet too long it will make it difficult to reestablish our good bacteria. Adjust the diet to your body do not stick strictly to diet but base it on how your body responds. I used a paleo diet after the FODMAP but did not stick to either diet strictly but based them on how my body responded.

https://gut.bmj.com/content/gutjnl/64/1/93.full.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830546/

paleo diet.

http://paleozonenutrition.com/2018/02/21/autoimmune-paleo-protocol-in-inflammatory-bowel-disease-clinical-study-shows-remission-in-73/

Akkermana Muciniphila It is found in the upper part of the intestines and helps regulate bile acid production. Bile acids help regulate our pancreatic enzymes so indirectly it also regulates our digestive enzymes. It is believe to restore the mucous membrane in the digestive system. Polyphenols from berries helps to feed it and increase it’s numbers. Oligosaccharides also increase A Muciniphila. It has been found to be low in those with obesity. A deficiency in A Muciniphila will cause a deficiency in short chain fatty acids and inhibited lipogenesis. A person deficient in A Muciniphila will develop insulin resistance and low glucose levels.

https://ubiome.com/blog/post/akkermansiamuciniphila/

http://www.mdpi.com/2076-2607/6/3/75

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614963/

Oligosaccharides and inulan have been shown to increase A. Muciniphila. This is why green algae and seaweed have so many health benefits they are high in oligosaccharides.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983298/

https://www.sciencedirect.com/science/article/pii/S1756464617301627

https://gut.bmj.com/content/67/2/271.long

Roseburia species help produce butyric acid, short chain fatty acid and protects us from diabetes and obesity. They help prevent inflammatory bowel disease. Beta Glucan in mushrooms and oats , chitan and inulin help raise Roseburia levels. Butyric acid protects the gut and our brains. It also protects our nerves and is important in the absorption of nutrient. If we are deficient in butyrate we will not absorb nutrients. Butter and ghee are good sources of butyrate until the gut bacteria are restored.

https://www.futuremedicine.com/doi/abs/10.2217/fmb-2016-0130?src=recsys&journalCode=fmb

https://gut.bmj.com/content/63/8/1275.long

https://academic.oup.com/femsec/article/87/1/30/508741

Faecalibacterium Prautsnitzii increases IL-10, this is important because Lyme and other illnesses that carry the OspA protein inhibit IL-10 to stealth themselves from the bodies immune defense. There isn’t much known about it except that it is low in many types of digestive disorders. We get it from being around others who have it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705805/

https://www.nature.com/articles/ismej2016176

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492426/

Clostridium Butyricum is a butyrate producing bacteria . Clostridum butyricum kills it’s cousin that cause negative health effects. It also increases IL-10 . It also decreases inflammatory cytokines. There are studies that have shown if the other healthy gut bacteria are not present this one like many of the bacteria species used in probiotics could start causing health problems.

https://www.ncbi.nlm.nih.gov/pubmed/30159141

https://www.ncbi.nlm.nih.gov/pubmed/30141701

https://www.ncbi.nlm.nih.gov/pubmed/29851202

It promotes better bowel movements.

https://www.ncbi.nlm.nih.gov/pubmed/30058712

https://academic.oup.com/cid/article/61/7/1107/289593

E Coli Nissle 1977 doesn’t only protect us from it’s cousins that cause ill health effects it also protects against other types of infections. It has been shown to put inflammatory bowel disorders into remission. It has too many benefits to mention. The only way I know of getting this one is through a probiotic called Multaflor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987069/

https://www.tandfonline.com/doi/full/10.3109/08910600903444267

E Coli Nissle 1977’s cousin can cause many health problems if not kept in check.

https://www.physiology.org/doi/10.1152/ajpgi.00091.2016

Lactobacillus Casei and L. Longum have been find to be deficient in many types of digestive disorders. They do not establish well of one or the other is missing it is best if they are taken together if you use a probiotic. The improve the bodies antioxidant capacity. We need SOD to produce H2O2 which the body uses to detox cells and transport nutrients and enzyme into and out of the cells. When deficient in these cellular macrophagy is inhibited. This help protect against cancer and other illnesses.

If we are deficient in them we can develop liver disease, lysosomal storage disorders and glycogen storage issues, insulin resistance and lose the ability to absorb nutrients. Our blood sugar levels will become low because insulin levels will increase. Bifidobacterium Bifidum has many of the same benefits and probably would benefit from taking it along with these. Also we cannot absorb proteins without the Lactobacillus strains.

https://www.hindawi.com/journals/omcl/2016/1340903/

https://www.ncbi.nlm.nih.gov/pubmed/30158369

They also help protect us from mold toxins.

https://www.frontiersin.org/articles/10.3389/fmicb.2018.01503/full

http://pubs.rsc.org/en/Content/ArticleLanding/2018/FO/C8FO00252E#!divAbstract

Lactobacillus Longum also produces folate for us.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654071/

protects our lungs.

https://www.ncbi.nlm.nih.gov/pubmed/30020533

https://www.ncbi.nlm.nih.gov/pubmed/24830455

Insulin and glycogen issues.

http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2016;volume=7;issue=1;spage=102;epage=102;aulast=Sharma;type=3

Protein absorption.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741550/

A species of bacteria called lactobacillus casei shiroto is important in regulating our tryptophan levels. A deficiency in this strain will cause reduce tryptophan levels resulting in anxiety and the inability to sleep. A deficiency in this one can result in phenylketonuria which causes high ammonia levels in the body. A person who has this issues will get ill when they eat meat , potatoes or other things high in phenylalanine. Low levels of tryptophan can cause a loss of the beneficial bacteria in the Roseburia family which can lead to leaky gut and inflammatory bowel disease and sever constipation.

https://aem.asm.org/content/82/12/3649

https://www.researchgate.net/publication/287309677_Lactobacillus_casei_Shirota_modulation_of_ammonia_metabolism_in_physical_exercise

Fermented milk like butter milk and kefir help them get established.

https://www.jstage.jst.go.jp/article/fstr/10/2/10_2_143/_article

Many have been found to be deficient in Streptococcus Salivarius protects us from lung, oral and nasal infections. It also protects us from inflammation. Those who are deficient in S Salivarius will be prone to infection especially from it’s cousins in the streptococcus family that cause negative health effects. The only way I know to safely increase this is with lozenges that contain it because too much can cause health problems so you would want to avoid taking capsules of this.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911234/

https://www.futuremedicine.com/doi/abs/10.2217/fmb.12.113?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=fmb

https://www.nature.com/articles/s41598-017-11446-z

Lactobacillus Rhamnosus helps prevent diarrhea , has been shown to reduce symptoms of inflammatory bowel disease. It helps protect us from infection. Helps protect us from allergies,obesity and diabetes. It also helps protect us from staph infection.

H Pylori is commensal but without Lactobacillus Rhamnosus to keep it in check it can cause gastric ulcers.

https://www.selfhacked.com/blog/l-rhamnosus/

https://aem.asm.org/content/80/18/5773

https://www.frontiersin.org/articles/10.3389/fmicb.2018.01873/full

We also need fungus for example Saccharomyces Cerevisiae know as brewers yeast helps prevent diabetes. They used to think S Boulardii was a separate species but it has been found to be the same. I couldn’t afford the supplement so I bout a package of brewers yeast and consumed it. Wasn’t sure it would make it through my stomach acid but I felt improvement so I believe it does. Now this is one you do not want to increase too much, also you do not want to take this if you have autoimmune issues or leaky gut. It can act as a pathogen if it gets into the blood stream, many of our microbiome can if they get too high in numbers or get into our blood stream.

https://www.ncbi.nlm.nih.gov/pubmed/23967428

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705302/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605952/

S Cerevisaiae helps reduce vaginalis and candida.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037478/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354225/

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1574-6968.2010.02037.x

Lactobacillus Rueteri produces folate those who have folate deficiency have been found to be low in folate and have high inflammation levels. L Rueteri also regulates our oxytocin which can give us a feeling of self worth and well being. A deficiency in L Rueteri can lead to extreme depression.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061717/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431580/

Our gut bacteria produce B vitamins for each other and maintain each other. If the ones who produce the B vitamins are missing then the microbiome will get them from our foods which will prevent us from receiving them. This is why it is important to eat foods high in B vitamins and to protect our gut bacteria from antibiotic, farm chemicals and toxins in our foods like artificial sweeteners.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403557/

Lactobacillus Acidophilus prevents diarrhea, helps protect against clostridium infections. Those with interstitial cystitis are usually deficient in this one. It helps reduce symptoms of inflammatory bowel disorder. Acidophilus regulates our ph of our digestive system and bladder and keeps it at the correct ph. Our bladders and digestive system need to be acidic. An akaline environment can cause a loss of our good gut bacteria and promote the growth of the bad. It can also cause candida to go from commensal to a pathogenic form. Many with interstitial cystitis have found relief using L Acidophilus suppositories. Those who are having difficulty gaining weight usually have excess L acidophilus levels because it speeds up metabolism and those who have problems with weight gain are often deficient in acidophilus. Fermented foods are high in this but those with high histamine must reduce their histamine before eating fermented food I addressed that in my autoimmune post.

https://www.healthline.com/nutrition/lactobacillus-acidophilus#section3

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705118/

Bifidobacterium increased the acid levels of our digestive tract which inhibits bad bacteria from growing and help keep our digestive tract acidic. It has been shown to reduce symptoms of irritable bowel disease.

https://www.nature.com/articles/ajg200925

Bifidobacterium Infantis protects us from autoimmune disorders by regulating our T cells. B infantis also helps protect our digestive tract.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277968/

https://www.ncbi.nlm.nih.gov/pubmed/28230606

This is an in depth discussion of probiotics.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424311/

more information on microbiome and folate production.

http://www.mdpi.com/2072-6643/3/1/118

Bifidobacterium Breve reduces symptoms of celiac disease.

https://www.ncbi.nlm.nih.gov/pubmed/26134988

Frequent constipation is a sign of a deficiency in the bifidobacterium species.

https://www.ncbi.nlm.nih.gov/pubmed/28884754

If we are deficient in the lactobacillus species we are more prone to salmonella infection.

https://www.ncbi.nlm.nih.gov/pubmed/29120368

https://www.ncbi.nlm.nih.gov/pubmed/28975642

Lactobacillus Bulgaris increases T Regulatory cells which prevents on over active immune response.

https://www.thieme-connect.com/DOI/DOI?10.1055/s-0043-117612

Too many Lactobacillus Delbrueckii can cause urinary tract infection.

https://jcm.asm.org/content/47/1/275

Our gut microbiome produce many of our nutrients so a deficiency in a specific strain can cause nutrient deficiencies especially in the B vitamins.

https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-017-0691-z

Quinones like PQQ is needed by our gut bacteria to thrive and balance out. They convert it to vitamin K2.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738691/

Phylloquinone (vitamin K) is also used by our gut bacteria and converted to vitamin K2. Animal products and leafy green vegetables are good sources of vitamin K . Many should be cooked especially spinach and kale because they are very high in oxalates.

http://www.jbc.org/content/283/17/11270.full

https://www.medicalnewstoday.com/articles/219867.php

https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/phylloquinone-vitamin-k1-intakes-and-food-sources-in-1864-year-old-irish-adults/00B5ECF7B563D1A3ADAA94986FC83223

Some food sources of quinones are. Natto, Green Tea, Parsley, Paypaya and green peppers. Some may benefit from supplementing PQQ because many of the foods that contain it are very high oxalate like kiwi.

https://biofoundations.org/dietary-sources-of-pyrroloquinolone-quinone-pqq/

https://optinghealth.com/foods-high-in-pqq/

Soil based probiotics have been shown to improve digestive health.

Bacillus Subtilis produces and antibiotic that protects us but is none toxic to the good bacteria. B Subtilis has antioxidant properties. B Subtilis has been shown to restore normal gut flora. B Subtilis has been shown to relieve constipation and diarrhea. It has reduce symptoms of inflammatory bowel disease. It boost immunity and fights H Pylori. It improves the health of the liver. It promotes the production of digestive enzymes which improves gut health.

https://www.ncbi.nlm.nih.gov/pubmed/21204933

https://www.selfhacked.com/blog/b-subtilis/

https://www.globalhealingcenter.com/natural-health/bacillus-subtilis-probiotic-strain/

Bacillus Coagulans improves insulan sensitivity. High insulin levels are common in inflammatory bowel disease, this would help reduce insulin levels. It helps reduce diabetes symptoms. B Coagulans improves muscle recovery and prevent arthritis. It helps increase the beneficial microbes in the gut. It relieves intestinal pain inflammation and constipation. B coagulans reduces the risk of urinary tract infections.

https://www.selfhacked.com/blog/b-coagulans/

https://www.verywellhealth.com/bacillus-coagulans-for-better-bowel-health-89601

Bacillus Clausii protects us from respiratory infection. It fights the infections that cause diarrhea. It reduces symptoms of inflammatory bowel disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936284/

https://www.omicsonline.org/open-access/bacillus-clausii–the-probiotic-of-choice-in-the-treatment-of-diarrhoea-2157-7595-1000211.php?aid=63792

Two soil based probiotics to watch out for because they can cause major health problems are bacillus Licheniforms and Enteroccocus Faecium.

Those with inflammatory bowel disorders have high bacteroides. They produce high levels of Beta Glucuronidase. This inhibits glucuronidation which is needed to detox mold toxins.

https://blog.healthmatters.io/2018/08/24/what-is-beta-glucuronidase/

http://www.pjm.microbiology.pl/archive/vol6232013319.pdf

Data overload hamster wheel.

This is not medical advice. It is an opinion based on my observations. This should not be taken as medical advice.
I keep seeing people do amazing research but they remain ill because they do not try anything because they develop paranoia from the data overload. So they run on this hamster wheel of ill health. You cannot get off the hamster wheel if you do not try something. Keep notes of your reactions and of what helps and what does not. You have to develop a protocol unique to you. It gives you a foundation to build from. Add one thing at a time so if you have a reaction you will be able to identify what had caused that reaction. It takes time and patients to heal. It takes a lot of research but it also take applying that research. There is a lot of misleading information out there take note of the source of information. If it is from the pharmaceutical industry then be cautious in trusting it they have a history of deception to promote their agendas to fatten their pocket books.
One example of the data overload hamster wheel are the people who are paranoid of oxalates. So much so that they will eat almost nothing and cannot heal because almost all foods has or will produce oxalates. The thing that produce oxalates only do so if there is a problem in the body. Instead of addressing the problems they run on a hamster wheel of fear of oxalates and never heal.
Then I see people with metabolic issues who have read so much misinformation that they do things that are detrimental to their health and just keep doing them remaining on the poor health hamster wheel. I have found many groups on Facebook I call hamster wheel groups. They have become so convinced of certain things they cannot see their way off the hamster wheel.
Another of the hamster wheel groups is the mold groups. They have become convinced the mold is the problem. The mold would not be able to infect the body or to effect it if something was not wrong. They complain about the mold and how they have to get out of it and become so convince it is the problem that they cannot see their way off the hamster wheel. Mold sensitivity is a symptoms and not the problem. People have lived in mold for many years and were never effected. They need to ask themselves what has changed? Why have people all of a sudden started developing problems that did not exist before?
The other hamster wheel groups are the autoimmune groups they go from an allopathic hamster wheel to a naturopathic hamster wheel. They take herbs to treat the symptoms instead of the cause. These groups cannot see out of the box so they view the symptoms as the cause. This is exactly what the pharmaceutical industry and allopathic medicine does. They get off one hamster wheel and jump on another.

My take on transdermal nutrient patches.

 

 

This is not medical advice, I am posting this for educational and information purposes.

I could not eat anything without getting ill. I seen many studies showing toxins absorb through the skin. Since I could not get my nutrients from food especially cholesterol, our body needs a lot of it. So I started using oils and some of them I would infuse with things that had nutrients. For example cucumber is high in choline so to get my choline I infused an oil using cucumber skin. My health improved dramatically. So I do believe transdermal vitamin patches work though the research on them is scarce.

Transdermal vitamins are not very effective unless they add something to cause the skin to absorb them. But the research shows using alcohol on the skin before applying the patch causes more of the nutrient to be absorbed.

https://www.ncbi.nlm.nih.gov/pubmed/25609377

When we have sulfation issues we can absorb magnesium sulphate (epsom salt) through our skin. Even when we have high sulfide levels it will not make a person ill because it is a type of sulfur the body can readily use. If you get sunlight afterwards it will help reduce certain hormone in the body that the sulfation issues have cause.

http://www.drmyhill.co.uk/wiki/Minerals_and_vitamins_delivered_through_the_skin

Vitamin E protects the skin.

https://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-E

Vitamin A can absorb through the skin but can irritate it.

https://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_199.pdf

Our skin does contain enzymes to break down nutrients.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0115359

Many studies have shown that essential oils are absorbed through the skin.

http://ndnr.com/mindbody/dermal-absorption-of-essential-oils/

Things that may help with lysosomal storage disease.

 

 

This is not medical advice. I am posting this for educational and information purposes.

Those who have lysosomals storage issues I notices also have gut issues. The post Things that may help those with the most difficult gut issues may help. It takes time to heal and lots of research and patients. You have to develop your own protocol there is no one size fits all. As you heal you have to adjust your protocol.

Humanin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800795/

Autophagy and immune system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766433/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036178/

https://www.sciencedirect.com/science/article/pii/S0022283618305308?via%3Dihub

Lithium helps with lysomoal protein degreadation by stimulating autophagy.

https://www.hindawi.com/journals/ijcb/2014/135908/

Inhibiting mTOR helps with lysosomal storage disease, by stimulating autophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437338/

https://www.jci.org/articles/view/94130

Autophagy helps correct Lysosomal Storage issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869865/

L-leucine and SPNS1 helps with LSD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698481/

SPNS1 is required for activation of mTOR to induce autophagy.

http://www.pnas.org/content/108/19/7826

https://academic.oup.com/toxsci/article/153/1/198/2223974

https://www.tandfonline.com/doi/full/10.1080/15548627.2016.1256934

Autophagy also corrects issues involved with fatty acid abosorptions.

https://www.ncbi.nlm.nih.gov/pubmed/28697336

Autophagy corrects lipid metablolism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930069/

Hypoxia increases V-ATPase. V-ATPase is needed for stomach acid production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543021/

Many with Lysosomal Storage issues have IBS, this is information on enzymes that may help.

https://www.dietvsdisease.org/digestive-enzyme-supplements/

https://www.sciencedirect.com/science/article/pii/S1590865818302093

Endothelium and LSD.

https://watermark.silverchair.com/cvq386.pdf?

http://journals.sagepub.com/doi/pdf/10.1177/1076029613489595

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579558/

Green Tea may help with LSD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452227/

Nobiletin may help with LSD by inducing autophagy. Autophagy helps clean out the celss.

https://www.sciencedirect.com/science/article/pii/S1388198118300350?via%3Dihub

https://www.ncbi.nlm.nih.gov/pubmed/28116779

https://www.annualreviews.org/doi/abs/10.1146/annurev-nutr-071715-050718?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=nutr

A list of nutrients that my restore autophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135626/

Spermidine found in wheat germ, mangos and mushrooms restore macrophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044119/

Exercise induces autophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463459/

Beta glucan may help with LSD.

https://academic.oup.com/femspd/article/35/1/67/529284

Beta Gucan may help.

https://www.researchgate.net/publication/259474009_Oat_beta-glucan_ameliorates_insulin_resistance_in_mice_fed_on_high-fat_and_high-fructose_diet

Whey protein may help.

https://www.researchgate.net/publication/8112776/download

Increasing TEFB expression may help with LSD.

https://www.ncbi.nlm.nih.gov/pubmed/27556060

Akt inhibition increases TEFB.

https://www.nature.com/articles/ncomms14338

Curcumin activates TEFB.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968239/

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006177

Autophagy corrects lipid metablolism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930069/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247383/

Sidt2 deficiency can inhibit autophagy.

https://www.ncbi.nlm.nih.gov/pubmed/29363559

Autophagy corrects lipid metablolism which is needed to produce bile and digestive enzymes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930069/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247383/

Hydrogen peroxide is needed for lipogenesis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369955/

https://www.sciencedirect.com/science/article/pii/S0014579300021979

SOD increases H2O2. The only bioavialable source in food is the chaga mushroom.

https://jonbarron.org/herbal-library/nutraceuticals/superoxide-dismutase

http://www.worthington-biochem.com/sodbe/default.html

Curcumin increase SOD but should not be taken too long it chelates iron and can cause anemia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705117/

http://www.raysahelian.com/superoxidedismutase.html

I found this study interesting ghrelin effects glycogen storage.

https://www.rug.nl/research/portal/files/14503024/06_c6.pdf

Things that may help those who have the more difficult digestive problems.

Mundinus,_Anatomia_Mundini..._Wellcome_L0027530

This is not medical advice I am posting this for informational and educational purposes.

If you truly want to heal it takes time and persistence. You have to develop your own protocol there is no one size fits all your protocol must be unique to you and your health problems. There is no magic bullet, pharmaceuticals treat the symptoms not the cause. So you may feel better but will slowly get worse until you will start needing other medications to hide the new symptoms that arise from the declining health which pharmaceuticals contribute to.

It takes a lot of research and patients. Take notes of what works and what does not and keep readjusting your protocol. As you heal your protocols will need to change.  Homeostasis is the goal once you start feeling better try cutting supplements out. If it goes well then take a maintenance dose of the supplement once in a while.

Mucilage every few hours helps a lot with leaky gut. When you have leaky gut it causes high oxalate levels. This causes a cycle that is hard to break because oxalates prevent the gut from healing. Mucilage can help heal the gut breaking the cycle. Mucilage helped me the most with healing my gut.

Things that are high in mucilage are Okra, organic Oatmeal, Aloe Vera I found the liquid gel worked the best dried aloe vera seemed ineffective. Besella Alba known as Malabar Spinach, Irish moss but you have to watch consuming it, it has a cannabinoid that reduces pain but has side effects if you consume too much. Most plants in the mallow family are very high in mucilage and have very good healing properties. Most plants in the dioscera family are high in mucilage especially the chinese wild yam. Fenugreek is high in mucilage. Flax seeds are high mucilage but if you have leaky gut they should be ground up to prevent other heath issues. Most seaweeds are high in mucilage. Licorice root is high mucilage but you have to make sure it is deglycyrrhizinated if not it can cause many health problems. Mullein is high mucilage and helps with lung infections. Most edible plants in the daisy and sunflower family are high in mucilage. Wild Daisy helped me a lot. Pysillium seed husk are high in mucilage they are seeds from the plantain herb. Plantain herb itself is very high in mucilage. Wild violet is very high in mucilage. Chia seed is high in mucilage most seed is. Slippery Elm is high in mucilage but some claim it is high oxalate , I have never tried it. Most roots herbs are high in mucilage. Arrow root is very high in mucilage.

https://mavcure.com/mucilaginous-herbs/

https://www.invitehealth.com/article-demulcents-and-mucilages-true-healers.html

Various gut microbiome and what they do.

https://www.vitamodularis.org/articles/how_to_interpret_your_microbiome_data.shtml

https://biofoundations.org/increasing-and-maintaining-akkermansia-muciniphila-for-a-healthy-gut-microbiome/

Oregano oil kills just about all pathongens in the gut.

https://www.bmj.com/content/352/bmj.i939/rr-1

Sage also is effective against bad gut bacteria.

http://www.scielo.br/scielo.php?pid=S0034-89102004000200025&script=sci_arttext&tlng=en

Verbana fights Citrobacter. I don’t know much about it but it has sedative effects and helps with seizures.

https://www.cogentoa.com/article/10.1080/23312009.2017.1363342.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5174135/

Beta Glucuronidase is low it can effect hormones. If it is high it can cause toxins reabsorption.

https://biofoundations.org/maintaining-a-proper-balance-of-beta-glucuronidase-for-disease-and-cancer-prevention/

High beta glucuronidase causes high estrogen.

https://www.planetnaturopath.com/hormones/high-beta-glucuronidase-and-how-it-affects-estrogen-and-detoxification/

Herbs that strengthen the immune system.

http://www.chiro.org/nutrition/FULL/Bacteria_That_Strengthen.shtml

We also need to reduce oxidative stress and nitrositive stress.

https://iamajuicer.wordpress.com/2018/08/02/oxidative-stress-the-antioxidant-systems-and-how-they-effect-our-health/

https://iamajuicer.wordpress.com/2018/07/11/nitrosative-stress/

Streptoccocus bacteria produce an exotoxins streptolysin and NAG -glycohydrolase which help it evade the immune system.

Inhibiting NLRP3 helps resolve the issues Streptolysin causes. It uses a tactic similar to Lyme disease it stimulates inflammation to evade the immune system.

https://www.frontiersin.org/articles/10.3389/fcimb.2018.00211/full

Rabdosia contains oridonin which inhibits NLRP3.

https://www.nature.com/articles/s41467-018-04947-6

There are a number of ways being used to inhibit NLRP3 inflammasome.

https://www.frontiersin.org/articles/10.3389/fphar.2015.00262/full

Resveratrol, quercetin and curcumin are NLRP3 inhibitors.

https://www.hindawi.com/journals/mi/2016/5460302/

Paeonia is a CBR2 activator which inhibits NLRP3.

https://www.ncbi.nlm.nih.gov/pubmed/25854559

CB2R receptor activation protects and heals the nerves.

https://www.nature.com/articles/cddis2014364

Hypoxia reduces NLRP3 and induces autophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524634/

https://www.tandfonline.com/doi/full/10.4161/auto.22783

bacillus subtillus kills most bad gut bacteria.

https://aac.asm.org/content/59/11/6844.full

https://www.tandfonline.com/doi/full/10.4161/viru.29514

https://www.sciencedirect.com/science/article/pii/S0168160511007136?via%3Dihub

We need butyrate producing bacteria to protect from inflammation. Also it protect the brain.

https://gut.bmj.com/content/63/8/1275.long

Fodmap diet helps with IBS.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555627/

Increasing Treg through FOXP3 cells helps.

https://www.hindawi.com/journals/jdr/2013/621693/

https://www.ndcn.ox.ac.uk/publications/692350

Our gut bacteria regualate T Reg cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276397/

https://ctajournal.biomedcentral.com/articles/10.1186/s13601-016-0108-9

Mycobacteria can inhibit NOD2 which can cause gut issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316803/

Infection can lead to NOD2 deficiency this causes a reduction in V-ATPase which is needed to produce stomach acid.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316803/

https://www.ncbi.nlm.nih.gov/pubmed/25335775

https://www.frontiersin.org/articles/10.3389/fimmu.2016.00367/full

Over stimulation of NOD2 can also make us prone to infections and chronic illness. Homeostasis should be the goal.

https://www.nature.com/articles/srep08383

https://www.spandidos-publications.com/10.3892/etm.2017.4288

https://www.kidney-international.org/article/S0085-2538(15)55943-7/pdf

HSP70 Restores NOD2 function. I have posted on HSP70

https://pubs.acs.org/doi/abs/10.1021/acs.biochem.7b00470?src=recsys&journalCode=bichaw

http://www.jbc.org/content/289/27/18987.long

Our diet and many probiotic strains can induce HSP70 which will restore NOD2 function which would restore dendric cell funtion.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892289/

Trypterygium Wilfordii may help restore NOD2 function though this is a single case report.

https://journals.lww.com/md-journal/fulltext/2017/11270/Case_report___remarkable_remission_of_SAPHO.114.aspx

Our diet and our gut interactions.

https://www.frontiersin.org/articles/10.3389/fimmu.2016.00290/full

Sulfation is involved in hormone production and use. Gut dysbiosis, glyphosate, mercury and other toxins can inhibit sulfation. This can result in hormone dysregulations. This can also result in high DHEA levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016456/

https://www.ncbi.nlm.nih.gov/pubmed/28153960

https://www.ncbi.nlm.nih.gov/pubmed/30087535

To much hydrogen sulfide producing bacteria lead to chronic illness.

https://www.physiology.org/doi/pdf/10.1152/physrev.00017.2011

https://pdfs.semanticscholar.org/1fda/f6c18c0b184ae8e41c8a777b2979bedd2494.pdf

Too many methane producing bacteria can lead to constipation there are some probiotics that will help with that.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609747/

http://www.talkingaboutthescience.com/studies/Donohue-Sulfoxidation.pdf

The craziest part of all of this is I seen supposed pathogens that could correct many of these issues but did not include them in this but they turn certain genes of which could restore the function of non-functioning genes.

Diets effect on gut bacteria.

https://www.aivpa.it/files/upload/rivista_articolo/00152_microbioma-dieta-disturbi-gastroenterici-e-disbiosi.pdf

https://watermark.silverchair.com/fux022.pdf?

http://www.drwallyschmitt.com/Newsletters/issue-43-molybdenum/

http://www.drmyhill.co.uk/wiki/Fermentation_in_the_gut_and_CFS

Tributyrin found in butter helps with dysbiosis

https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.994.9

https://biofoundations.org/multiple-health-benefits-tributyrin-triglyceride-form-butyrate/

Sulfur regulation in the body is very improtant.

https://www.mthfrsupport.com.au/wp-content/uploads/2017/04/PPT-CBS-Pathway-Final-full-page-slides.pdf

Dysbiosis often leads to impaired renal function.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431124/

Those who have gut issues will be deficient in short chain fatty acids and they are very important in maintaining our health.

https://biofoundations.org/multiple-health-benefits-tributyrin-triglyceride-form-butyrate/

Many will have high oxalate levels which are produced endogenously. I have posted on oxalates. This can prevent the gut from healing.

https://mthfrsupport.com/2018/03/understanding-sulfation-and-oxalate/

http://www.lowoxalate.info/research.html

https://people.csail.mit.edu/seneff/DC2016/CynthiaSmith_DC2016.pptx

Autophagy corrects lipid metablolism which is needed to produce bile and digestive enzymes. Bile homeostasis is very important for the health of the whole body.

http://jem.rupress.org/content/early/2018/01/12/jem.20171965.long

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930069/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247383/

Hydrogen peroxide is needed for lipogenesis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369955/

https://www.sciencedirect.com/science/article/pii/S0014579300021979

SOD increases H2O2. The only bioavialable source in food is the chaga mushroom.

https://jonbarron.org/herbal-library/nutraceuticals/superoxide-dismutase

http://www.worthington-biochem.com/sodbe/default.html

Curcumin increase SOD but should not be taken too long it chelates iron and can cause anemia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705117/

http://www.raysahelian.com/superoxidedismutase.html

http://www.foodtrients.com/inside/sod-do-you-know-about-this-powerful-antioxidant/

Sidt2 deficiency can inhibit autophagy. Unfortunately I have not research this Gene much.

https://www.ncbi.nlm.nih.gov/pubmed/29363559

Though I do not believe in taking enzymes the body can produce if all else fails what else are we to do. Often times taking enzymes the body can produce can disable the bodies ability to produce them.

https://empoweredsustenance.com/fat-malabsorption/

Increasing brush oder enzymes helps with malabsorption.

https://www.ncbi.nlm.nih.gov/pubmed/11346204

You must heal the endothelium to correct malabsorption. Saccharomeyces Boulardii is needed for that. This also improve lipid abosorption.

https://www.ncbi.nlm.nih.gov/pubmed/29762474

https://metabolichealing.com/villous-atrophy-leaky-gut-intestinal-dysbiosis/

Dietary nucleotide supplementation helps heal the digestive tract.

https://www.sciencedaily.com/releases/2014/04/140416143313.htm

https://www.selfhacked.com/blog/dietary-nucleotides-health-benefits-of-nucleotides/

https://www.researchgate.net/publication/275771517_Nucleotides_supplementation_improves_various_function_of_the_body

https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1440-1754.2002.00056.x

Mucins and tight junctions regulate what passes in and out of the intestines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548832/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095905/

High zonulin levels causes the gut to become more permeable.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458511/

High zonulin levels has been linked to many diseases.

https://www.mygenefood.com/zonulin-leaky-gut/

https://www.jillcarnahan.com/2013/07/14/zonulin-leaky-gut/

Probiotics to reduce zonulin.

https://www.realnatural.org/probiotics-help-reduce-intestinal-permeability-also-called-leaky-gut-syndrome/

colostrum reduces zonulin.

https://www.researchgate.net/publication/316676047_Oral_Supplementation_with_Bovine_Colostrum_Decreases_Intestinal_Permeability_and_Stool_Concentrations_of_Zonulin_in_Athletes

https://www.naturalnewsblogs.com/healing-leaky-gut/

Brush border enzymes are needed to break down and absorb food.

http://www.vivo.colostate.edu/hbooks/pathphys/digestion/smallgut/bbenzymes.html

https://www.core3training.com/can-improve-gut-overall-health/

Black Seed Oil improves carbohydrate digestion.

https://www.ncbi.nlm.nih.gov/pubmed/28959553

Thyme improves brush border enzymes.

https://www.ncbi.nlm.nih.gov/pubmed/29223554

How bile is secreted.

https://www.ncbi.nlm.nih.gov/pubmed/29262229

http://www.sophiahi.com/how-to-increase-your-digestive-fire-by-jeannie-oliver-chc-cpt/

Foods that contain natural digestive enzymes.

https://www.healthline.com/nutrition/natural-digestive-enzymes#section2

They mention Kiwi in this one. It is high oxalate so would not be good for someone who has leaky gut.

https://starmystuff.com/top-7-foods-contain-natural-digestive-enzymes

 

I am sorry these are things I forgot to post with this post. It is concerning restoring the ability to produce short chain fatty acids.

Diasccharidase in involved in our digestion and absorption of carbohydrates and sugars. If we are not producing enough then our food will sit and ferment in our upper intestine possibly feeling like a brick is sitting in our stomaches. This will cause excess gas and can lead to the production of hydroxl sulfide which inhibits sulfation and can cause issues with the CBS and BH4 pathways. This can lead to high ammonia levels, proteinuria, phenyketonuria and even porphria. Infection can cause this, an imbalance in our gut bacteria brought on by farm chemicals especially glyphosate, antibiotics, and even chemicals found in processed food. If you have diarrhea and you are not absorbing then you may be producing too much disaccaride which is an indication of high insulin levels. High oxalates will prevent the gut from healing. I have posted on oxalates and the gut. If we produce too much diasaccaride then we will experience similar symptoms only instead of being constipated we would have diarrhea.

https://drhoustonanderson.com/disaccharidase-deficiency-causes-and-treatment/

Vinegar seemed to help me but this studies shows it actually reduces Disaccharidase. Not sure what to think about this one.

https://academic.oup.com/jn/article/130/3/507/4686196

We know those with IBD usually have high insulin levels showing they have lost their sensitivity to insulin. This leads to high leptin levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159716/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959465/

I know those with IBD connot do some of these things. You have to learn to figure out what in the information that is out there you can apply and what you cannot.

https://www.healthline.com/nutrition/improve-insulin-sensitivity#section8

Though being insulin resistant is usually found in obesity it is common in many inflammatory bowel disorders.

Increasing insulin sensitivity will help with leptin levels.

https://www.marksdailyapple.com/25-ways-to-improve-your-insulin-sensitivity/

https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/

Increased insulin levels inhibits disaccharidase levels.

https://www.ncbi.nlm.nih.gov/pubmed/21946084

Decreased insulin levels increases disaccharide levels.

http://www2.ufpel.edu.br/biotecnologia/gbiotec/site/content/paginadoprofessor/uploadsprofessor/8aff603648377229ebdb3b655ecdf854.pdf

Now if you look at MAPK it is involved in IBD. So now we can see the connections. We need to increase insulin sensitivity . I read many research articles and decreasing insulin levels seem to make IBD worse but improving insulin sensitivity improved IBD. Inhibiting TNF-a improves insulin sensitivity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792822/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859792/

There are naturals that inhibit TNF-a but nothing that inhibits it directly. Also inhibiting it for too long makes us more prone to infection.

https://www.researchgate.net/profile/Solomon_Habtemariam/publication/12454244_Natural_Inhibitors_of_Tumour_Necrosis_Factor-a_Production_Secretion_and_Function/links/09e4150bb180eefd74000000/Natural-Inhibitors-of-Tumour-Necrosis-Factor-a-Production-Secretion-and-Function.pdf?origin=publication_detail

Resvertrol inhibits TNF-a it is found in grape seed extract.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091406

Reducing insulin levels reduces P38 MAPK which reduces symptoms of IBD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218950/

Those who have IBD have been found to be deficient in bacteria in the up digestive track especially Oscillospira and Akkermansia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573342/

https://helda.helsinki.fi/bitstream/handle/10138/236401/Akkermansia_muciniphila.pdf?sequence=1

Lactobacillus Fermentan increases Akkermansia.

https://www.ncbi.nlm.nih.gov/pubmed/28935567

Host microbe prebiotic and fiber interactions. Interesting lets you know how each type of saccharide effects the gut bacteria.

https://www.tandfonline.com/doi/full/10.1080/19490976.2017.1290756?src=recsys

Studies confuse me, some says stay away from carbohydrates will others show that those carbs increase the very bacteria those who have IBD are deficient in.

https://academic.oup.com/jcem/article/101/1/233/2806797

Beta Glucan found in Oats and mushrooms increases Oscillospira.

https://www.frontiersin.org/articles/10.3389/fmicb.2017.00966/full

Meditarrian diet can increase Oscillospira.

https://www.ncbi.nlm.nih.gov/pubmed/26505825

L-arginine has been found in many studies to help normalize the gut bacteria even in chickens.

https://www.ncbi.nlm.nih.gov/pubmed/28901890

Nanosilver can kill specific gut bacteria depending on the size and shape. In theory this could be used to reduce specific gut bacteria that may be too numerous.

https://www.researchgate.net/publication/241100111_Comparison_of_the_anti-bacterial_activity_on_the_nanosilver_shapes_Nanoparticles_nanorods_and_nanoplates

The shape of the silver determines which bacteria it is effective against.

https://www.ncbi.nlm.nih.gov/pubmed/28588204

Glutamine reduces Oscillospira which would be detrimental to IBS.

https://cfsremission.com/2017/10/15/decreasing-oscillospira-genus/

Black Raspberries increase Oscillospira.

https://www.ncbi.nlm.nih.gov/pubmed/29502392

Most with IBD are difficient in Oscillopira. This is found in the upper digestive tract. I believe it is the cause of the low disaccharidase production but I cannot find studies to prove it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437018/

A deficiency in Oscillopira causes food allergies.

Food additives have a negative impact on the gut.

https://www.ncbi.nlm.nih.gov/pubmed/29914144

This is a good list of bacteria and what they do. Bifidobacteria Bifidum and Breve increase short chain fatty acid production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964481/

Our gut bacteria regulate cell that produce antibiotics.

https://www.frontiersin.org/articles/10.3389/fmicb.2018.00736/full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801817/

More on Oscillopora.

https://www.datapunk.net/substrata/display.pl?119852+S

Bile acid also increases Oscillopora.

https://onlinelibrary.wiley.com/doi/abs/10.1111/1758-2229.12319

https://drjockers.com/25-ways-improve-gallbladder-health/

Gut homeostasis is controlled by the endocannbinoid system. Those with inflammatory bowel issues have been found to have low endocannbinoids. This raises diaglycerols which can prevent the proper production of digestive enzymes leading to the inability to digest and absorb saccharides and produce short chain fatty acids (carbohydrates and sugar). This is caused by the upregulation of the protein kinase pathway.

https://www.ncbi.nlm.nih.gov/pubmed/22917662

Black pepper increases endocannbinoids which would help with IBD.

https://www.ncbi.nlm.nih.gov/pubmed/24412246

HSP70 is a transport for anamide and other endocannabinoids. I have posted on HSP70.

FAAH inibitors increase endocannabinoids.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882713/

Biochanin A found in read clover, the red covering on peanuts, and in chick peas is an FAAH inhibitor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931556/

Here is information on other cannabinoids and their effects on the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429335/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538700/

Kaempferol found in pine tree bark extract and magnolia is an FAAH inhibitor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538700/

Bilirubin is inhibited with IBD and other inflammatory bile diseases. This is cause by the inflammation which can lead to scarring and obstruction of biliary ducts. Serrapeptase helps remove scar tissue and so doe HSP70. Also using anti-inflammatory herbs helps.

http://www.crohnscolitisfoundation.org/resources/liver-disease-and-ibd.html

https://inflammatoryboweldisease.net/symptoms/complications/gallstones/

https://kresserinstitute.com/little-known-connection-leaky-gut-gluten-intolerance-gallbladder-problems/

This is the oddest part about IBD and other inflammatory diseases. TMAO is low in those who have an intestinal inflammatory disease. Most have too much of the bacteria that produces TMAO but those with IBD have too few.

https://www.ncbi.nlm.nih.gov/pubmed/26160437

This is a list of gut bacteria that increase TMAO consuming choline will increase these bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453578/

https://lpi.oregonstate.edu/mic/other-nutrients/choline

https://draxe.com/what-is-choline/

Faecalibacterium Prausnitzii has been found to be low in those with inflammatory bowel disease. This causes a dificiency in nicotinic acid which leads to an increase in phenylalamine. This lead to a conditions called phenyketonuria which causes high ammonia levels in the body and can effect many metabolic pathways and cause us to become ill when we eat meat, potatoes or anything else that has phenylalanine in it. A deficiency in Faicalibacterium Prausnitzii also results in high cadaverine and putrescine levels which causes inflammation.

https://emedicine.medscape.com/article/945180-overview?pa=70SvUf61EZjJeh01GcM07cjK0CdaeXT%2FVguJkgES6Vuf4MsXKJuI2VMwKp69ZMinm%2BKlpX80V6KaHMrB8SW%2FFlaycSibeA0Q%2FJsWK%2BpGHzs%3D

https://www.healthline.com/health/phenylketonuria

Our gut bacteria need iron tho thrive but the iron they fortify food with is the wrong type. Iron found in curly dock and burdock root will supply you with iron without causing toxicity unless you have certain liver diseases. If you have iron toxicity lactoferrin will restore iron homeostasis. Curcumine will reduce iron levels in the blood also but do not take it too long or you can become anemic.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491036/

Ghrelin stimulates our appetite and increase stomach acid.

https://www.theunion.com/news/twi/glyphosate-roundup-and-its-link-to-celiac-disease-gluten-intolerance/

Fatty acid and vagus nerve stimulate ghrelin.

https://academic.oup.com/abbs/article/41/3/188/655

https://www.ncbi.nlm.nih.gov/pubmed/29632576

https://www.selfhacked.com/blog/32-ways-to-stimulate-your-vagus-nerve-and-all-you-need-to-know-about-it/

https://thelivingproofinstitute.com/19-ways-to-stimulate-your-vagus-nerve/

https://www.psychologytoday.com/us/blog/the-athletes-way/201607/vagus-nerve-stimulation-dramatically-reduces-inflammation

I had to alternate types of diets until I got things straightened out. I had to do a FODMAP diet first then as I healed I had to switch to a Paleo diet. Then when I had healed enough I was able to fast it took me a while to build up to being able to fast for a day. Some can go longer and it is dangerous for others like those with lysosomal storage issues.

https://paleoleap.com/butyrate-anti-inflammatory-fat/

Hydrogen Sulfide produced by gut bacteria can cause sulfation issues.

https://sibosurvivor.com/hydrogen-sulfide-sibo/

When we have too much hydrogen sulfide being produce by our gut microbiome it will cause us to become constipated.

 https://www.ncbi.nlm.nih.gov/pubmed/28971603

https://www.sciencedirect.com/science/article/pii/S2213007117300485

now you have reached a state that has caused a cycle that is hard to break and results in ulcerative coalititis and even IBS.

 https://link.springer.com/article/10.1023/A:1018867516575

Excess H2S causes low blood pressure and a reduced body temperature. It will slow our metabolism causing us to feel drowsy.

http://www.ei-resource.org/…/gut-bacteria-the-hydrogen…/

The inhibited phosphorylation causes a deficiency in the redox ions needed by many metabloic pathways. Mainly Mg2+, Mn2+, Zn2+ and indirectly Ca2+. So it pretty much shuts cellular function down.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010430/

Not all will get drowsy with the inhibited phosphorylation it may cause NMDA issues which is what happened to me. When this happens and your glutamate levels sky rocket it will fell like your head is going to spit open, you will not be able to sleep and you will experience anxiety.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966912/

This thread is long enough but the can effect the CBS and BH4 pathways which can lead to sulfur intolerance and meat intolerance. Even after correcting this problem you have to heal the gut and get the oxalates down to restore the function of the metabolic pathways.

http://www.talkingaboutthescience.com/studies/Donohue-Sulfoxidation.pdf

Having to many H2S producing bacteria has been shown to raise blood levels of H2S. I could not find studies on the prolonged effects but I have found information on prolonged exposure. It causes sulfhemoglobin which cannot be broken down by the body.

http://www.theijoem.com/ijoem/index.php/ijoem/article/view/482

https://www.ncbi.nlm.nih.gov/pubmed/25237136

https://www.frontiersin.org/articles/10.3389/fped.2018.00098/full

Thiamine and B6 deficiency can cause high oxalates.

https://www.ncbi.nlm.nih.gov/pubmed/3947375

https://draxe.com/thiamine-foods/

the gut and cholestokinin

http://www.yourhormones.info/hormones/cholecystokinin/

https://www.selfhacked.com/blog/good-bad-effects-cck/

Trypsin inhibitors increase cholecystokinin.

https://naldc.nal.usda.gov/download/26115/PDF

Things that raise GABA like , mugwort, wormwood and rooibos reduces cholecystokinin levels. High estrogen levels cause high cholecystokinin levels. High dopamine levels increases cholecystokinin. High levels of cholecystokinin causes glutamate toxicity and NMDA toxicity.

https://www.acnp.org/g4/GN401000056/CH056.html

Potatoes increase cholecystokinin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033477/

If not addressed it leads to autism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628252/

Proprionate is high in Ibs. This strikes me as odd because acetate and butyrate are low in IBS. How can one short chain fatty acid be high and the test dificient?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847229/

https://www.healthline.com/nutrition/short-chain-fatty-acids-101#section1

High proprionate can cause loss of appetite and weight loss.

https://gut.bmj.com/content/64/11/1744

it is from having to high of bacteroides.

https://jb.asm.org/content/jb/134/1/84.full.pdf

This article partially explains the high bacteroides levels.

http://humanfoodproject.com/going-feral-one-year-journey-acquire-healthiest-gut-microbiome-world-heard/

Meat increases bacteriodes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820228/

meat alkalizes the gut so it makes sense that those with IBD may consume more meat which will make them have raised bacteroides levels. This can lead to many health problems.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949257/

Betaine reduces bacteriodes by increasing stomach acid.

https://www.selfhacked.com/blog/tmg-health-benefits/

http://drlwilson.com/articles/TRIMTHYLGLYCINE.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176045/

Snail1 involvement in inflammatory bowel diseases indicates macrophagy issues.

https://www.ncbi.nlm.nih.gov/pubmed/21830269

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0450-z

Macrophagy issue also cause lipogenesis issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108423/

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0450-z

Glycolysis issues are also an indication of inhibited macrophagy and sure enough those with inflammatory bowel disorders have glycolysis issues.

https://onlinelibrary.wiley.com/doi/abs/10.1002/ibd.21388

Macrophagy genes have been impicated in inflammatory bowel disease.

http://www.els.net/WileyCDA/ElsArticle/refId-a0025006.html

Good information from my friend David Anderson.

For people with digestive issues

Hydrophilic colloidal diet

1. Hydrophilic colloids bring about conditions in the stomach during digestion which approach those resulting from the consumption of foods in their natural state.

2.Hydrophilic colloids lessen gastric irritation by absorbing the digestive secretions of the stomach so that digestion takes place within a mass of food.

3. Gelatin, because of its availability, relatively low cost, non-toxicity, adaptability as an item of dietary and its thorough digestibility becomes an admirable hydrophilic colloid for dietary usage.

4. The amount of gelatin to be used in a given case depends on the patient’s needs, but it must be of good quality and sufficient in amount.

5. It has a wide range of usefulness in gastrointestinal ailments ranging from the atonic conditions met in the chronic invalid to the irritating condition presented in gastric ulcer.

In some instances, gelatinized arrowroot powder has been used to achieve similar results.. Arrowroot/pectin, etc… Could possibly be used if oxalates are an issue.

 

https://link.springer.com/article/10.1007%2FBF03010602

 

Medium chain triglycerides improve bile flow and decrease bile reabsorption.

https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2014/06/Parrish-February-17.pdf

https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-018-0267-x

MCTs help heal leaky gut and inflammatory bowel disorders.

https://www.ncbi.nlm.nih.gov/pubmed/27187452

https://www.frontiersin.org/articles/10.3389/fimmu.2016.00290/full

Organic acids help heal the gut mucosa.

https://www.researchgate.net/profile/Ulker_Eren2/publication/282700134_Effects_of_dietary_organic_acid_supplementation_on_the_intestinal_mucosa_in_broilers/links/5649b1d908ae451880af661a/Effects-of-dietary-organic-acid-supplementation-on-the-intestinal-mucosa-in-broilers.pdf?origin=publication_detail

http://www.mdpi.com/2072-6643/9/9/920/pdf

file:///home/homuser/Downloads/nutrients-09-00920.pdf

They recommend glutamate in this. That is not correct because those with inflammatory bowel issues have high bacteriodes and glutamate feeds them which can make things worse. But there is useful information in this.

There is an error in this. Those with inflammatory bowel have high bacteroides which causes a lot of problems. They claim glutamate helps but it feeds bacteroides so would make things worse but I found useful information in this.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622680/

Interesting information on inflammatory bowel disease.

https://www.hindawi.com/journals/mi/2017/6869259/

Those with inflammatory bowel issues are low in biotin which is probably caused by the inflammation inhibiting absorption.

https://europepmc.org/abstract/med/19056639

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129763/

A biotin deficiency causes the inability to break down proteins, fats and other nutrients.

https://www.physiology.org/doi/abs/10.1152/ajpcell.00141.2016

Those with inflammatory bowel usually have low biotin which can cause many metabolic issues. Biotin needs Adenosylcobalamin which is a form of B12 in the body. Some may have to supplement if the body is not converting it.

Adenosylcobalamin helps with biotin absorption and use.

https://www.globalhealingcenter.com/natural-health/adenosylcobalamin-4-facts-know/

Biotin and pantothenic acid compete for absorption and pantothenic acid can inhibit biotin absorption.

https://www.ncbi.nlm.nih.gov/pubmed/9814986

Alkaline Phosphotase is low in those with inflammatory bowel disorders. Lactobacillus Casei increases it and will help with nutrient absorption.

https://www.ncbi.nlm.nih.gov/pubmed/22783049

Before increasing it make sure you know the dangers of too much.

https://www.selfhacked.com/blog/alkaline-phosphatase/

How to increase ALP.

https://health.onehowto.com/article/how-to-increase-alkaline-phosphatase-11707.html

http://www.newhealthguide.org/Low-Alkaline-Phosphatase.html

If you take curcumin once the gut bacteria start getting established stop taking it. It can cause anemia because it chelates iron.

https://www.ncbi.nlm.nih.gov/pubmed/25474287

Cissus stimulates ALP.

https://www.ncbi.nlm.nih.gov/pubmed/25449449

https://examine.com/supplements/cissus-quadrangularis/

High estrogen levels effect bile production. Bile protects the intestines from inflamation.

https://hormonesbalance.com/articles/gallbladder-hormone-balance-connection-mean-dont-gallbladder/

Hormones involved with bile flow.

https://hormonesbalance.com/articles/gallbladder-hormone-balance-connection-mean-dont-gallbladder/

Inhibited bile flow can cause estrogen dominance.

http://www.jbc.org/content/early/2018/06/21/jbc.RA118.001789.full.pdf

This causes a cycle that is hard to break and results in high cck levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756670/

Activation of the CCK1 receptor by estrogen can lead to gall stones.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037422/

Dim3 (diinoylmethane) inhibits the estrogen receptor which should lower cholestokinin levels.

https://www.ncbi.nlm.nih.gov/pubmed/25486199

http://joe.endocrinology-journals.org/content/195/3/393.full.pdf

Things that inhibit Era.

https://www.hindawi.com/journals/omcl/2018/6040149/

They mentioned soy isoflavons in the previous study but it could make things worse.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633874/

ursolid acid that was mentioned is found in the wax on skins of apples , in rosemary and thyme.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379974/

 

These are enzymes and hormones that are usually dis-regulated in inflammatory bowel.

Cholesterols function in bile secretion. Issues with the liver X receptor can cause issues with cholesterol metabolism.

http://www.jbc.org/content/278/18/15565.long

https://www.ncbi.nlm.nih.gov/pubmed/29523554

Olive Oil help resolve liver X receptor issues. But inhibits glucuronidation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521785/

Butyrate found in butter and ghee also help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111843/

High estrogen inhibits sulfation. Increasing UDP-glucuronosyltransferases will reduce estrogen levels.

http://www.jbc.org/content/275/46/36164.full.pdf

http://dmd.aspetjournals.org/content/30/5/564

DHA, oleic acid, and linoleic acid inhibit those enzymes.

https://www.nature.com/articles/srep02903

Foods that increase UDP-glucuronosyltransferase.

http://dmd.aspetjournals.org/content/30/5/564

https://www.heart-health-guide.com/apigenin.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874462/

https://www.selfhacked.com/blog/apigenin-top-11-science-based-health-benefits-apigenin/

Luteiolin is good at increasing UDP-glucuronosyltransferase.

http://secretsofnaturalhealing.blogspot.com/2010/12/luteolin-rich-foods-shown-to-reduce.html

https://www.selfhacked.com/blog/top-11-science-based-health-benefits-luteolin/

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166239

Diosmetin is found in the white parts of citris fruit and dates.

https://pubs.acs.org/doi/abs/10.1021/jf502359x?src=recsys&journalCode=jafcau

https://www.researchgate.net/publication/228115816_Bioactivity_of_Diosmetin_Glycosides_Isolated_from_the_Epicarp_of_Date_Fruits_Phoenix_dactylifera_on_the_Biochemical_Profile_of_Alloxan_Diabetic_Male_Rats

 

 

 

 

 

Germ Theory and Terrain Theory are wrong.

 

 

 

 

Terrain theory is wrong and so is germ theory. I will add more links showing this is true as I find them. Our group on Facebook Synergistic Illness has come up with a theory we call “Enviromental Biome Theory of Health. ” . Our environment as a whole effects our health and if you read my post on here on “It is not your genes it is your gut bacteria” or “Vaccines spread disease they do not prevent them” and many other of my post support this theory. The health of our soil is important because if it is healthy then the plants are healthy providing more nutrients. If there are chemicals and toxins in the soil they effect the body and cause us to be susceptible to things making us ill that would normally be beneficial. I covered that in my post
“Things Science has wrong”.

In this post i am showing how our gut microbiome regulate our gene expressions and our immune system. They also are responsible for all types of immunity in the body. I posted the links to the other blog post that support this at the bottom of this post.

 

Bifidobacterium feed each other.

If we was all like Bifidobacterium the world would be a better place.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623478/

How our bodies feed our bacteria.

https://www.frontiersin.org/articles/10.3389/fmicb.2017.00484/full

Inflammation causes a loss of pattern recognitions sensor which is how HIV and cancer become established.

https://www.frontiersin.org/articles/10.3389/fimmu.2014.00367/full

Inflammation can also lead to NAFLD.

http://stke.sciencemag.org/content/sigtrans/10/491/eaal3336.full.pdf

Ketogenic diet restores gut balance.

https://www.nature.com/articles/s41598-018-25190-5/

Importance of being eubiotic

https://www.omicsonline.org/open-access/the-importance-of-being-eubiotic-2329-8901-1000162.php?aid=88559

how our gut bacteria regulate our gene expressions. Too many of some and not enough of others can lead to cancer, autoimmunity, even COPD.

https://www.nature.com/articles/cmi20187

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1019.4532&rep=rep1&type=pdf

http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005579

https://gutpathogens.biomedcentral.com/articles/10.1186/1757-4749-5-23

Irritable bowel syncrome.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525272/

Our gut microbiome regulate whether we get cancer or not.

https://msystems.asm.org/content/3/3/e00205-17

Our gut bacteria effect whether we are obese and whether we develop heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063892/

Metabolic issues and autoimmune issues need to be addressed or our genes cannot communicate with our gut bacteria this can lead to diabetes.

http://jem.rupress.org/content/early/2016/09/07/jem.20160526

Our genes communicate with our gut microbiome.

http://jem.rupress.org/content/215/8/1965.long

http://cancerres.aacrjournals.org/content/77/8/1783

Our gut microbiome prevent bone loss through the production of SCFA.

https://www.nature.com/articles/s41467-017-02490-4

Our gut bacteria regulate our T cells and B cells.

https://www.tandfonline.com/doi/full/10.1080/19490976.2017.1299311

https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.febslet.2014.04.007

T cells turn genes on and off making us susceptible to illness if there is an imbalance.

https://www.nature.com/articles/ncomms4551

When you read the following studies you will see the connection with this one and how our gut help develop humoral immunity.

https://www.ncbi.nlm.nih.gov/pubmed/27760339

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916850/

Our microbiome regulate our T cells so it is a microbiome cycle of communication.

http://www.pnas.org/content/114/21/5497.long

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080902/

IgA is needed for our gut microbiome to become established.

https://authors.library.caltech.edu/85463/

http://science.sciencemag.org/content/360/6390/795.long

Now if you read this study you will see that our gut microbiome regulate our immune system. It is a cycle so we need diversity. Now there are many things that can disrupt this cycle. T cells are needed to keep this cycle going and there are many things that can cause a T cell imbalance.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451207/

Certain strains of bacteria can restore IgA production.

https://www.nature.com/articles/s41598-018-23404-4

Our diet effects our gut bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787545/

Resveratrol helps restore MyD88 function.

https://www.ncbi.nlm.nih.gov/pubmed/30107238

MyD88 is needed to fight pathogens. It causes an immune response by causing inflammation.

http://www.jbc.org/content/280/32/29242.full

The Nrf2 pathway is needed to prevent excess inflammation from MyD88 activation. Blocked Nrf2 will cause excess inflammation.

https://www.sciencedirect.com/science/article/pii/S0006291X10021108

https://www.cell.com/cell-reports/abstract/S2211-1247(15)00802-5

IL-10 prevents MyD88 from causing exciess inflammation.

http://www.pnas.org/content/106/43/18327.full

Along with our T cells and B cells our gut bacteria also regulate IL-10.

https://www.hindawi.com/journals/jir/2014/586939/

Issue with the retinoic receptor can also inhibit our gut bacterias communication with our cells.

https://www.nature.com/articles/mi2016114

It is important for that communication to keep our body from attacking our good gut bacteria.

https://www.nature.com/articles/nature10434

Those who have an over active immune response would want to avoid TLR2 agonist they increase the immune response and the inflammation. This would help those who have low CD4 counts.

http://www.jimmunol.org/content/jimmunol/186/2/1119.full.pdf

Coriolus mushroom is a TLR2 agonist which would stimulate the immune system.

https://www.ncbi.nlm.nih.gov/pubmed/21068144

Turkey tail mushroom also is a tlr2 agonist.

http://dl.begellhouse.com/journals/708ae68d64b17c52,5c93eb0962bab6ac,34fa1edb20739135.html

Spirulina increases cd4 T cells.

http://www.mdpi.com/2072-6643/6/7/2973

Those with HIV lack the gut bacteria that stimulate CD4 cell production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891875/

These are things that help with HIV.

http://www.greenmedinfo.com/blog/38-natural-alternatives-hiv

Yogurt increases CD4.

https://insights.ovid.com/pubmed?pmid=20463586

Phloretin is a TLR2 inhibitor. This reduces the immune response and would reduce inflammation.

http://www.mdpi.com/2072-6643/10/7/868

Biacalein is a tlr2 inhibitor.

https://www.hindawi.com/journals/bmri/2012/267890/

We need to keep in mind that our immune system protects us from cancer so loss of MyD88 can lead to cancer.

https://www.sciencedirect.com/science/article/pii/S0304383518304440

Inhibiting mTOR restores MyD88 this would help with inflammation and HIV.

http://www.jimmunol.org/content/187/11/6052

MyD88 is needed to fight infection but if it is over stimulated it can cause health problems.

http://www.pnas.org/content/111/10/3799.full

So what could cause these cytokine storms that will not shut down. Well vaccines have been well documented for causing such reactions.

https://www.researchgate.net/publication/7105965_The_TLR4_agonist_monophosphoryl_lipid_A_attenuates_the_cytokine_storm_associated_with_respiratory_syncytial_virus_vaccine-enhanced_disease

Over active MyD88 can lead to cancer, lupus and other autoimmune diseases , in autoimmunity TLR are up-regulated which activates MyD88 causing a cytokine storm. If you look at the studies below then look at documented vaccine injury cases you will see they are connected.

http://jem.rupress.org/content/212/13/2184

http://www.pnas.org/content/110/35/E3311.long

https://link.springer.com/article/10.1007%2Fs12016-013-8402-y

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708030/

http://www.bloodjournal.org/content/101/9/3495?sso-checked=true

The harmfull effects of pesticides and herbicides to the gut have been well documented.

http://www.mdpi.com/1099-4300/15/4/1416

https://www.sciencedirect.com/science/article/pii/S0041008X13000549

this is a good article explaining how toxins effect our gut. I have posted on things that effect the gut bacteria. Now we know that they regulate our immune system and many of our genes anything that effects our gut bacteria including dyregulation in B cells or T cells causes a loss of communication with our gut bacteria leading to chronic illness.

https://iamajuicer.wordpress.com/2018/07/16/modern-medicine-is-not-based-on-science/

https://iamajuicer.wordpress.com/2018/07/19/synergistic-illness/

https://iamajuicer.wordpress.com/2018/06/27/its-not-your-genes-it-is-your-gut-microbiome/

https://iamajuicer.wordpress.com/2018/06/17/vaccinations-spread-and-cause-disease/

https://iamajuicer.wordpress.com/2018/07/23/how-toxic-is-your-food/

Things that may help with fatigue.

Kids_‘n_Fiber_(6120828233)

This is not medical advice if you are ill see a doctor. I am posting these for educational and informational purposes.

Things to help the adrenals. This list needs updated I did this one a few years ago.  I have better notes but needed to post this for now and will update it with links when I get the time.

If you have not detoxed you need to detox first or you will be defeating the purpose. I posted a previously on detoxing.

Stress is a killer to the adrenals studies have shown those who read and apply the bible and pray and have faith and act on it handle things that most could not, they also live longer.

Having high cortisone levels can cause much damage in the body. When you are ill some times the adrenals can get stressed from over producing cortisone.

The next thing is to focus on positive things. Look for good in people as much as possible. Take the time to look at the sky, the stars, nature. Do little things that make you happy.

Studies have shown that those who take an interest in others can deal with stress better and are happier so try to help others or just call to so hello and let them know you care.

Studies have shown that positive social interactions even on social networks reduce stress levels.

Avoid Orexin inhibitors like processed sugar, leptin, opoids, cannaboids, nociceptin and berberine.

De-Glyanized Licorice Root – if Licorice Root is not de-glyanized it is very harmful. It does help normalize the adrenals and ease the symptoms of leaky gut and interstitial cystitis.

Ginkgo Biloba – lowers cortisone levels. Studies have shown long term use can cause liver damage.

Shisandra – reduces stress hormones.

Rhodiala – lowers stress hormones, increases stamina. This herb has many healing properties.

Ornithine – reduces cortisone, helps with fatigue and helps the body excrete ammonia.

Glycine – lowers cortisone, reduces adrenal fatigue, inhibits bacterial overgrowth, helps remove ammonia from the body, usually low in vegetarians.

Taurine – helps to sleep, use at night because it has sedating qualities, most vegetarians are low in taurine. Also reduces cortisone levels.

Threonine – helps in the metabolizing of proteins. Needed for proper functioning of the brain.

Coconut Oil – Contains caprylic acid and monolauren. They protect and heal the brain. They also help fight many pathogens.

Cholesterol – needed for proper function of the brain, used by all parts of the body.

Perriwinkle contains Vinocetine – has nuero protective properties, improves blood circulation in the brain, kills many pathogens, also has anticonvulsant properties, and reduces inflammation.

Lysine – needed to produce serrotonin.

Chlorella – boost energy levels, removes heavy metals including mecury. Make sure you do not have sulfation issues because it is high in sulfur. Also make sure it is not from contaminated sources.

NAC (N-Acetyl-L-Cysteine) has antidepressant properties, prevents aluminum toxicity, helps the body to remove many other toxins. Helps repair DNA and improves blood circulation. This should not be taken everyday. Studies have shown that taking this too often results in it having the opposite effects.

Glycerophosphate – reduces symptoms of depression, helps the body to produce new bone growth.

Methylene Blue – reduces symptoms of depression, reduces Alzheimer symptoms , has been shown to extend lifespans. If you are anemic or G6PD deficient you cannot take this. I can be purchased at most drug stores.

PPQ (Pyrroloquinoline) Enhances mitochondria function, improves memory, protects and heals the nerves, improves sleep and moods, helps to reduce cortisol.

Bacopa – has been shown to help heal brain damage, also lowers ammonia levels. Has been shown to improve blood flow and heal blood vessels.

Maca Root – stimulates and nourishes the hypothalmus and pituatory glands. Helps restore the bodies electrolytes, also high in energy.

Lotus Root – reduces cortisone, strengthens the immune system, Has been shown to improve gut health.

Glycoproteins – help provide the brain with energy, they promote healthy cell to cell communication. They have been shown to fight many pathogens. They prevent carcinogens from attacking the cells. They strengthen the immune system. Can be found in whey protein and mushrooms.

Zinc – protects our memory, necessary for the synthesis of proteins. Zinc is needed for the proper function of the immune system. It also aides in the repair and function of DNA. Do not get to much of it or it will push the copper from your body. I get mine from organic raw honey.

Fisetin – reduces inflammatory cytokines, can up-regulate gluthione production. Protects the brain and nerves.

Catuba Bark – opens blood vessels and improves circulation, has anti inflammatory properties, has antidepressant properties, reduces symptoms of Parkinsons disease. Shown to be affective against HIV and other viruses. Has been shown to heal the gut.

Eucommia Root (siberian gensing)– helps to stabilize blood pressure, strengthens the immune system, helps the adrenals by lowering cortisone. Note that not all Ginseng is the same, each has it’s own benefits. Siberian Ginseng helps lower cortisone, and has been shown to improve mental health. It is an adaptogen, studies have shown that it strengthens the immune system. It has been shown to reduce the outbreak of herpes. !! If you have high blood pressure do not take. !!

Lions Mane Mushroom – reduces plaque in the brain, protects the brain and nervous system.

Hops – lowers cortisone, has been shown to improve brain function, is a relaxant that has been shown to improve the function of the thyroids. Protects the cardiovascular system, heala the adrenal system. !!Too using too much can cause seizures. !! Has a cannabinoid similar to THC.

Thyme – boost the feeling of well being, increases the production of white blood cells. Relaxes the muscles, has been shown to reduce oral infections. Has many minerals needed by the body. !! If taken in large doses it has many side affects. !!

Hovenia Dulcis (japanese raison tree) – has been shown to protect the brain and nerves, has also been shown to protect the renal system.

Polygala Teniofolia – reduces cortisone and improves memory.

Arginine – improves exercise tolerance, improves blood flow, helps regulate creatine levels which if they get low it hinders brain function. Promotes Nitrous Oxide production. If under a lot of oxidative stress or nitrosative stress I would not take this.

Theanine – has calming affect, reduces mental confusion, fights cancer and heart disease. !! Toxic in high doses. !!

Manganese – neccassary for pituatary function.

Ashwanga – lowers cortisone, improves muscle strength, also improves the health of the cardiovascular system. Has benefits throughout the body. !! Has many side affects if taken in large quantities and can cause misscariages. !!

Cellery Seed – protects the brain, reduces histamines, reduces risk of stroke.

Avena (Oat Straw) reduces cortisone, balances electrolytes, improves the health of the lymphatic and cardiovascular systems. Is a relaxant.

Choline – The brain is mostly fat, choline helps the body break down and use fats more effectively which improves the health through the body. Also provides the brain and body with more energy. Some with certain health issues will not be able to convert choline. In those instances sun flower seed lecithin will help. Those with issues involving choline will get indigestion and may not produce the digestive enzymes they need.

Collinsonia Root – reduces cortisone, strengthens and heals the cardiovascular system, heals the gut has been shown to reduce pain.

Inositol – reduces anxiety, makes you feel happy, helps reduce symptoms of depression and OCD. Reduces the occurrence of mood swings.

Cholesterol – necessary throughout the whole body, the brain and heart cannot function it levels get too low. You will also develop leaky gut if cholesterol levels get too low. Progenolone is the type of cholesterol that heals the nerves and brain.

Wormwood and mugwort– reduces swelling in the brain, has been shown to stimulate healing in the brain. Kills many pathogens and has been shown to improve problems with the bladder. They also raise GABA levels which helps give the feeling of well being.

Curcumin – increases brain growth factor, reduces inflammation throughout the body. If taken for too long it can make a person anemic. It chelates iron from the body.

Omega 3 Fatty Acids – inhibits brain cell death, helps reconnect damaged nuerons.

Glycogen – fuels the brain when awake, needed by the body when under oxygen depletion, decreases aggression and irritability. The liver stores some amounts but if they get to low it affects the cognitive functions. Good sources are organic honey and organic black strap molasses.

P5P and Methylcolbamin – they both improve brain function and healing. They need magnesium to work.

Gaba (Gamma-Ammino-Butyric-Acid) – Calms nerves, normalizes brain waves and stimulates human growth hormone, improves production of endorphins.

Astaxanthin – Crosses the blood brain barrier to heal the brain, provides the brain with energy, reduces peroxidation, improves symptoms of many brain disorders.

Nobiline – repairs brain and nerves, repairs DNA and is neuro protective. It stimulates cellular macrophagy so you would not want to use this often.

Lemon Balm – improves sleep, improves memory problems and problem solving. Has calming affect, relieves pain.

Pycogenol – reduces symptoms of Alzheimer, protects nerves and brain, improves memory, reduces symptoms of endometriosis.

Anise – reduces brain fog, reduces lipid peroxidation, protects the gut.

Valine – helps improve sleep, maintains muscle function and growth, heals the nervous system increases exercise endurance. Can be found in kidney beans.

 

Fatty Liver, Cirrohsis, thrombosis and other diseases caused by fibrosis.

 

 

Gray1086-liverThis is not medical advice. I am posting this for educational and informational purposes. It takes time, persistence and research to heal.

Fibrosis can result in excess blood clotting, muscle damage, NAFLD, COPD and many other illness. I have posted on oxidative stress, inflammation and infection. I have also posted on toxins like glyphosate, glufosinate, mercury and detoxing them. All those things can cause fibrosis. Modern medicine looks at the symptoms and not the cause for example when the liver or lungs are failing they view those as the problem but most things like that are from a systemic failure throughout the body caused by many things. If you read my post it is your gut and not your genes you will see many things they blame on genetics can be corrected in the gut. Even thought this post is about NAFLD these things should help with just about any illness caused by fibrosis including thrombosis (blood clotting) because many of them have similar causes.

Ways NAFLD developes

https://www.futuremedicine.com/doi/full/10.2217/pgs-2016-0047

Genes and NAFLD, keep in mind things they thought were genetic and could not be changed they have found can be and people can heal.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0050256

Good list of supplements for NAFLD.

https://www.nationalnutrition.ca/HEALTHCONCERNS_fatty_liver_disease.aspx

https://www.atkins.com/how-it-works/library/articles/to-protect-your-liver-take-five

Foods that may help.

https://naturalon.com/fight-fatty-liver-disease-with-these-12-natural-methods/view-all/

Krill Oil and other fats may help with fatty liver.

https://www.omicsonline.org/open-access/oral-intake-of-krill-oil-has-prophylactic-and-potential-therapeutic-effectson-alcoholic-fatty-liver-in-rats-fed-with-highfat-diet-2167-0501-1000189.php?aid=61584

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268598/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930973/

https://www.ncbi.nlm.nih.gov/pubmed/8979168

Pantethine has been shown to reverse fatty liver disease.

https://www.ncbi.nlm.nih.gov/pubmed/11425046

https://universityhealthnews.com/daily/heart-health/5-powerful-pantethine-benefits/

Benfotiamine may help with fatty liver.

http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2002907

https://www.iasj.net/iasj?func=fulltext&aId=4371

Ubiquinol helps reduce fatty liver.

http://healthandscience.eu/index.php?option=com_content&view=article&id=623:supplements-of-q10-may-help-people-with-liver-disease&Itemid=198&lang=en

https://alsearsmd.com/2016/08/non-alcoholic-fatty-liver-disease/

https://articles.mercola.com/sites/articles/archive/2011/06/29/this-form-of-co-q-10-found-far-superior-to-one-typically-being-sold.aspx

Low P5P can cause fatty liver disease.

https://www.gastrojournal.org/article/S0016-5085(84)80110-9/pdf

https://paulaowens.com/vitamin-b6-deficiency/

PPC may help with fatty liver.

https://academic.oup.com/jn/article/127/9/1800/4728940

SAM helps with fatty liver.

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1530-0277.2008.00803.x

https://academic.oup.com/ajcn/article/76/5/1183S/4824268

Carnitine helps with fatty liver.

http://care.diabetesjournals.org/content/38/7/1245.long

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209366/

Those with fatty liver have been found to be low in magnesium. This can be cause by oxidative stress, inflammation , toxins and metabolic disorders.

https://www.ncbi.nlm.nih.gov/pubmed/29435319

https://www.nature.com/articles/s41598-017-18076-5

Fruit vinegars help with fatty liver.

https://www.tandfonline.com/doi/full/10.3109/13880209.2015.1031910

http://fattyliverdietreview.com/does-apple-cider-vinegar-help-with-a-fatty-liver/#axzz5OBoTWWyi

Alpha R-lipoic Acid helps with fatty liver.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929137/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976966/

Treatment options for NAFLD.

https://www.wjgnet.com/1007-9327/full/v23/i36/6549.htm

Nattokinase also reduces fibrinogen which would help with COPD and NAFLD.

https://www.sciencedirect.com/science/article/pii/S0271531709000220?via%3Dihub

This is a site with a list of things that can cause NAFLD. Most of these issues I have posted on if you search my blog.

https://mybiohack.com/blog/nafld-nash-cld

Renal function can improve at any stage of illness.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081835#s4

In some Tenascan-C becomes activated which can lead to fibrosis throughout the body including the liver and lungs.

http://news.feinberg.northwestern.edu/2016/06/mechanism-behind-chronic-fibrosis-discovered/

Illnesses that cause damage to the body from increased inflammation and oxidative stress can cause raised Tenascan-C levels.

https://pdfs.semanticscholar.org/226c/57aec0c9e736f0253a1f8c4e2c31c63d3c6d.pdf

Tenascin-C is high in tissue injury which is why it is important to address the issues that are causing the injury. Whether it is metabolic issues, nutrient deficiencies, toxins , infection or oxidative stress.

https://www.e-sciencecentral.org/upload/molcell/pdf/molcell-34-1-35-5.pdf

Ace inhibitors may help with fatty liver. I have posted on natural ACE inhibitors in my hypertension post.

https://www.ncbi.nlm.nih.gov/pubmed/18239590

https://fg.bmj.com/content/5/4/277

Vitamin E found in things like Olive Oil and Fish Oil helps with fatty liver.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789322/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712166/

Vitamin D deficiency or a number of metabolic disorders or toxins can prevent the body from converting vitamin D to D3. Low levels of D3 can increase Tenascan-C levels. Supplementing with D3 may reduce Tenascan-C levels.

https://www.sciencedirect.com/science/article/pii/S0014579398003482

Alcoholics get cirrhosis of the liver because it depletes the nutrients (cofactors) needed for sulfation and glucuronidation.

https://www.ncbi.nlm.nih.gov/pubmed/3081005

Cholesterol dysregulation and NAFLD.

http://www.cell.com/cell-metabolism/abstract/S1550-4131(12)00144-1#.V3mMaZ8-dsE.facebook

Homocysteine NAFLD

https://www.sciencedirect.com/science/article/pii/S0014579309001860

Betaine, Homocysteine, NAFLD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642650/

Those who have issues with thiols cannot take betaine. I have posted on thiols.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265525/

Estrogen PEMT

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430895/

Estrogen,PEMT and choline deficiency.

https://www.ncbi.nlm.nih.gov/pubmed/21059658

Choline deficiency can lead to NAFLD, there also also metabolic issues that can interfere with the bodies use of choline.

https://www.ncbi.nlm.nih.gov/pubmed/21059658

A deficiency in PEMT enzymes leads to fatty liver.

https://www.news-medical.net/news/20160307/Absence-of-PEMT-enzyme-leads-to-development-of-fatty-liver-disease-and-tumours-in-thin-patients.aspx

The vagus nerve can effect PEMT levels.

https://www.ncbi.nlm.nih.gov/pubmed/25433161

Misaligned vertebrae and vagus nerve.

https://www.atlantotec.com/en/fundamentals/autonomic-nervous-system

Dysregulation of PEMT will result in liver dysfunction from choline deficiency. It is not mentioned in this study but nutrient deficiencies and metabolic issues like inhibited sulfation and issues with thiols can cause this. I have posted on those. Carcinogenic estrogen can build up in the body effecting these receptors. This can be caused by vaccine injury, heavy metals and glyphosate. Under normal health estrogen induces PEMT. PEMT homeostasis is important for preventing fibrosis throughout the body.

http://www.beyondmthfr.com/estrogen-methylation-and-choline-deficiency/

http://www.beyondmthfr.com/mthfr-digestion-methylation-connection-gallbladder-function/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020773/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430895/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601486/

A deficiency in PEMT leads to fatty liver disease.

https://www.news-medical.net/news/20160307/Absence-of-PEMT-enzyme-leads-to-development-of-fatty-liver-disease-and-tumours-in-thin-patients.aspx

http://roosclues.blogspot.com/2017/02/gallbladder-disease-connection-between.html

This is a more in depth article on PEMT.

http://geneticgenie.org/blog/2013/10/21/acetylcholine-deficiency-in-chronic-illness-the-hunt-for-the-missing-egg/

PEMT issues can result in lung dysfunction.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983399/

High levels of certain gut bacteria , and high endotoxin levels can cause PEMT issues. I have posted on gut bacteria and how to reduce the strains mentioned, I think it was in my gut bacteria post. Leaky gut and infection causes high endotoxin levels and I have posted on how to address those.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049827/

https://www.sciencedirect.com/science/article/pii/S2542568418000041

SNAIL1 inhibition can reverse fatty liver caused by PEMT dysfunction.

https://www.spandidos-publications.com/etm/14/5/4231

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020706/

A natural pesticide form the melia toosendan tree inhibits SNAIL1. It is used to get rid of parasites in the body.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/ptr.6132

https://www.sciencedirect.com/science/article/pii/S0367326X14002561

Eucalyptol is a SNAIL1 inhibitor.

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=22311&path%5B%5D=70602

Insulin resistance caused by inflammation and oxidative stress can lead to NAFLD.

https://www.sciencedirect.com/science/article/pii/S0925443914002579

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265866/

Betaine (TMG) helps with fatty liver.

https://academic.oup.com/ajcn/article/80/3/539/4690529

Antitrypsins defiency can lead to NAFLD. Raw egg whites and Lima beans inhibit trypsin but I do not know if it will help , I could not find research on humans. Though there are studies on mice that show beans that have trypsin inhibitors in them being effective. There are studies showing the trypsin inhibitors in beans fight cancer.

https://www.sciencedirect.com/science/article/pii/S0954611111000515

https://www.sciencedirect.com/science/article/pii/S0271531715002808

https://www.hindawi.com/journals/bmri/2010/219793/

Ursodeoxycholic acid reduces liver fibrosis. Inhibited sulfation can cause a deficiency in ursodeoxycholic acid. It can also cause sulfated ursodeoxycholic acid to build up in the liver causing damage. This can also cause problems in the intestines, resulting in inflammation and even intestinal lesions. There are a number of things that cause liver fibrosis and many of them can be addressed by increasing the gut bacteria that produce ursodeoxycholic acid.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024236/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082879/

http://www.em-consulte.com/en/article/100091

https://www.wisegeek.com/what-is-ursodeoxycholic-acid.htm

I gut bacteria help keep our liver healthy.

https://www.sciencedirect.com/science/article/pii/S2212877816300564

https://www.ncbi.nlm.nih.gov/pubmed/28983453

Our gut bacteria also protect our livers from infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097911/

Parental nutrition effects the health of an infants liver.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622747/

Enterococcus Lactis protects the liver from oxidative stress.

https://www.ncbi.nlm.nih.gov/pubmed/21778036

Oligosaccharrides increase the beneficial bacteria that produce ursodeoxycholic acid, this helps with liver fibrosis which has been found to be common in those with SIBO.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812493/

Obeticholic acid reduces liver fibrosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970222/

Bile acid dysfunction has been connected to many chronic illnesses.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966875/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874546/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535499/

Metabolic issues effect bile acid production which can lead to illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954621/

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157427

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=22803&path%5B%5D=71990

Our gut bacteria regulate our bile acids, bile acid dysfunction can lead to kidney and liver disease.

http://www.mdpi.com/2072-6643/9/10/1124

https://www.nature.com/articles/nrgastro.2018.23

https://www.cell.com/cell-metabolism/pdf/S1550-4131(16)30223-6.pdf

https://www.hindawi.com/journals/grp/2015/398585/

https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-017-0462-7

https://academic.oup.com/ndt/advance-article-abstract/doi/10.1093/ndt/gfy172/5043141#.W1TXZnvKNpQ.facebook

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229528/

Lithium in low doses heals the kidneys in high doses it can damage them.

https://www.physiology.org/doi/abs/10.1152/ajprenal.00145.2016?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

https://nutritionreview.org/2013/04/lithium-orotate/

Dybiosis can cause poor liver health regardless of our body fat levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780381/

Fasting increases HSP70 which helps with NAFLD. I have posted on HSP70

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0110748

Ginseng may help with liver fibrosis.

https://www.jstage.jst.go.jp/article/bpb/41/4/41_b17-00934/_article

https://www.kgcus.com/blog/benefits-of-ginseng-in-treating-liver-function-problems-and-diseases/

Oligosacharride helps normalize our gut bacteria.

https://www.jstage.jst.go.jp/article/jnsv/63/4/63_269/_article

https://www.physiology.org/doi/pdf/10.1152/ajpgi.00324.2015

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157427

https://www.sciencedirect.com/science/article/pii/S0016508517356986

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0117851

This study shows the importance of bile acid homeostasis in the prevention of NAFLD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651899/

Nrf2 regulates bile acid homeostasis. I covered Nrf2 in my antioxidant post.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947974/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420438/

https://www.physiology.org/doi/full/10.1152/ajpgi.00322.2010

Trehalose reduces oxidative stress by regulating Nrf2/keap1 pathway and induces autophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730428/

https://www.ncbi.nlm.nih.gov/pubmed/26905426

Choline metabolism and our gut bacteria are connected to liver disease. A sign of metabolic issues that need addressed is gall bladder trouble and indigestion when eating foods high in choline.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601486/

We need to get the correct fats an adequate amounts of cholesterol for bile production. We also must address issues that may cause a loss of cholesterol and fats by oxidation . I have posted on oxidative stress and inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811459/

I have posted on thiols. Cholesterol dysregulation can cause NAFLD.

https://www.cell.com/cell-metabolism/abstract/S1550-4131(12)00144-1#.V3mMaZ8-dsE.facebook

Hemochromatosis can cause liver fibrosis. They claim it is genetic but I have seen studies showing toxins, infection and excess oxidative stress can cause it. Curcumine also reduces iron overload but taking it for too long can cause anemia. Lactoferrin reduces symptoms of iron overload by normalizing levels of iron in the blood though I have not research the safety of it’s use in liver disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657669/

This is a list of herbs that helps with hemochromatosis.

https://academic.oup.com/jn/article/143/7/1061/4637651

Liver fibrosis is caused by increased collagen production.

https://www.spandidos-publications.com/mmr/13/5/4335

Porphyria can lead to fatty liver. I have posted on it.

http://europepmc.org/articles/PMC3021615

http://www.porphyriafoundation.com/about-porphyria/types-of-porphyria/PCT

Stringy Stonecrop help with liver fibrosis.

https://www.sciencedirect.com/science/article/pii/S0024320514004135?via%3Dihub

NAD+ may help with fatty liver.

https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.13513

Eleuthero reduces fatty liver.

https://link.springer.com/article/10.1007/BF02974078

Diosmetin found in citrus fruit reduces liver fibrosis.

https://www.ncbi.nlm.nih.gov/pubmed/27101925

Inhibiting USAG1 may help with Alport Syndrome. Proteinuria is part of the problem with Alport Syndrome. If I get a chance I will research the effects of protease on Alport Syndrome.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2827946/

Biochanin A which is found in red clover and in the red papery covering of peanuts prevents liver fibrosis.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0069276

Relaxin helps reduce lung fibrosis which would help with COPD.

https://www.frontiersin.org/articles/10.3389/fphar.2017.00318/full

Bacteriodes Fragilis reduces liver injury.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097911/

I found this interesting IDO deficiency causes liver fibrosis. IDO deficiency can be caused by metabolic issues, toxins like mercury, glyphosate and glufosinate. Infection cause high quinolinic acid levels which can cause IDO deficiency. Also toxins from mold can cause IDO deficiency. High IDO levels can cause cancer so this is not something you would want to increase but something you would want to restore homeostasis to.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012673/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415894/

http://chikd.org/journal/view.php?id=10.3339/chikd.2015.19.2.79

https://www.washingtonpost.com/news/to-your-health/wp/2018/03/10/dentists-keep-dying-of-this-deadly-lung-disease-the-cdc-cant-figure-out-why/?utm_term=.c4eac3e7e373

High MMP levels causes fatty liver.

https://www.ncbi.nlm.nih.gov/pubmed/23136827

https://www.ncbi.nlm.nih.gov/pubmed/29856896

This is a list of MMP inhibitors. I find it strange that many of these also fight viruses.

https://www.sciencedirect.com/science/article/pii/B9780444626158000035

http://researchinventy.com/papers/v7i2/B07020410.pdf

Fraxinux Excelsior seed helps reverse fatty liver.

https://www.researchgate.net/publication/276144825_Preventive_Effect_of_a_Fraxinus_Excelsior_L_SeedsFruits_Extract_on_Hepatic_Steatosis_in_Obese_Type_2_Diabetic_Mice

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1398-0

https://www.omicsonline.org/open-access/preventive-effect-of-a-fraxinus-excelsior-l-seedsfruits-extract-onhepatic-steatosis-in-obese-type-2-diabetic-mice-2155-6156-1000527.pdf

Theraputic targets to help with fibrosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326607/

Those with liver fibrosis have been found to be deficient in Vitamin A.

https://academic.oup.com/ajcn/article/102/1/130/4564323

Other vitamin deficiencies connected to liver fibrosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849418/

Zinc deficiency is common in cirrhosis of the liver.

https://www.ncbi.nlm.nih.gov/pubmed/1505922

Berberine helps with NAFLD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947506/

Metabolic issues, oxidative stress, toxins especially mecury and glyphosate can cause the loss of retinoic acid receptor. I have posted on how to address those things.

https://www.sciencedirect.com/science/article/pii/S1386634605003128?via%3Dihub

Rumex Visicarius can help prevent liver disease.

https://www.ncbi.nlm.nih.gov/pubmed/25702903

Burdock root is hepaprtoective.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355822/

Kudzu has many healing properties. It is hepaprotective.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733283/

Though this is the kidneys I am sure this could happen in the liver also. Infection especially tick born illness can cause antiphospholipid syndrome. Vaccine injury can also cause this. Antiphospholipid syndrome can cause fibrosis in the kidneys.

http://www.scielo.mec.pt/scielo.php?script=sci_abstract&pid=S0872-01692017000300009

Paeony helps reduce symptoms of kidney disease.

https://link.springer.com/article/10.1007%2Fs11255-016-1345-5

Low carbohydrate diet reduces kidney disease in diabetes. I have posted on diabetes. This would be a temporary fix. It is better to address the issues causing it.

https://www.sciencedaily.com/releases/2011/04/110420184429.htm

List of herbs that help cleanse the kidneys.

https://www.top10homeremedies.com/kitchen-ingredients/top-10-super-herbs-to-cleanse-your-kidneys.html

Many medications can cause liver fibrosis especially fluoroquinolones.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654244/

http://www.ajhp.org/content/71/1/37?sso-checked=true

https://pubs.acs.org/doi/abs/10.1021/pr401230s

Murcormycosis is a lung infection and if not addressed it can lead to liver disease and COPD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309303/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828593/

Cristifolin found in Joe Pye helps with liver fibrosis but it contains an alkaloid that can build up in the body so I would not recommend over use.

https://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-957558

How isoflavones protect the liver.

https://www.wjgnet.com/1007-9327/full/v21/i4/1099.htm

Sirt1 activators help reduce NAFLD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555103/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440403/

Inhibited Sirt.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710930/

Silymarin found in milk thistle seed inhibits mTOR which has been found to help with NAFLD.

https://www.ncbi.nlm.nih.gov/pubmed/26186142

Stevia Extract has hepaprotective properties.

https://www.sciencedirect.com/science/article/pii/S1056872712002802

Glyphosate causes liver damage resulting in liver fibrosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600513/

http://www.organic-systems.org/journal/92/abstracts/Swanson-et-al.html

https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-015-0109-2

https://www.nature.com/articles/srep39328

Cathepsin B causes NAFLD.

http://www.jbc.org/content/early/2017/12/19/jbc.M117.778365.full.pdf

There are natural Cathepsin inhibitors but have not found studies on their effectiveness.

https://www.sciencedirect.com/science/article/pii/B9780444637499000062

https://www.omicsonline.org/open-access/cathepsin-b-inhibitors-for-targeted-cancer-therapy-1948-5956.1000302.php?aid=32883

Japanese Honeysuckle helps with liver fibrosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632443/

Plantain herb is hepaprotective.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861812/

Artichoke is hepaprotective.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879230/

Yarrow protects the renal system and reduces oxidative stress.

yarrow protects the renal system.

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.1897

reduces oxidative stress.

https://www.hindawi.com/journals/ecam/2013/893050/

https://www.researchgate.net/publication/317632510_Pharmacognosy_Phytochemistry_and_Pharmacological_Properties_of_Achillea_millefolium_L_A_Review

http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_HMPC_assessment_report/2011/09/WC500115468.pdf

Ginger is hepaprotective and reduces oxidative stress.

https://www.sciencedirect.com/science/article/abs/pii/S0753332218316688

https://www.sciencedirect.com/science/article/abs/pii/S0753332218324168

Hibiscus is in the mallow family. Most plants in the mallow family are hepaprotective.

Hibiscus is hepaprotective.

https://www.sciencedirect.com/science/article/pii/S030881461400692X?via%3Dihub

Rose hip is hepaprotective.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877970/

https://www.ncbi.nlm.nih.gov/pubmed/23880806

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485961/

White malberry helps with NAFLD

https://www.sciencedirect.com/science/article/pii/S0009279717311377?via%3Dihub

https://www.jfda-online.com/article/S1021-9498(17)30196-5/fulltext

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981255/

https://foodandnutritionresearch.net/index.php/fnr/article/view/1289

Sages have many healing abilities. Red Sage helps with liver fibrosis.

Red Sage helps reverse liver fibrosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054956/

Sirt activators help with NAFLD. Resveratrol found in grape seed extract is a sirtian activator.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155167/

Beta Glucan found in mushrooms, whey protein and whole grains help with liver fibrosis.

Beta glucan protects from fibrosis which is found in COPD and NAFLD.

https://www.europeanreview.org/article/8816

Rooibos protects the renal system by reducing oxidative stress.

It also protects the renal system the same way.

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-392

Causes of lipid storage disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879869/

Oxidative stress causes renal damage, this is how Tylenol causes liver damage. Corn Silk helps protect the liver from oxidative stress, it is yummy to.

https://www.hindawi.com/journals/ecam/2016/2046298/

miR22 promotes liver fibrosis.

http://www.jbc.org/content/288/51/36202.full

miR22 is modulated by our gut bacteria, our mRNA communicate with our gut microbiome. So if we have undressed health issues then this could be disrupted.

https://ucdavis.pure.elsevier.com/en/publications/butyrate-induces-ros-mediated-apoptosis-by-modulating-mir-22sirt-

https://www.frontiersin.org/articles/10.3389/fmicb.2018.00151/full

Plants that should be avoided because they have alkaloids that can destroy the liver or kidneys.

Plants with poison alkaloids.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983973/

Lipoxin reduces inflammation which should help with NAFLD. I have not had a chance to research how to increase lipoxin.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598198/

I do not like metformin because of the effects of long term use on the body. I am posting this to show that folic acid is toxic to the body and is used to damage the liver of animals in test. It is man made and our bodies make very little of the enzyme needed to break it down. This causes the excess that cannot be broken down to enter the blood stream causing damage throughout the body. Folate which is natrual does not have this effect on the body. They fortify our food with folic acid making it toxic, so those with NAFLD should try to avoid foods containing folic acid.

https://www.ncbi.nlm.nih.gov/pubmed/29380373

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340065/

Glycogen storage disease.

http://themedicalbiochemistrypage.org/vongierkedisease.php

Beta Glucuronidase is bad for NAFLD but helps with lysosomal storage disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC294437/

Those with NAFLD can be deficient in B12

https://www.b12-vitamin.com/blood-levels/

Mitochondrial disfunction is common in NAFLD, PQQ improves mitochondrial function.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140972/

Hibiscus is hepaprotective.

https://www.sciencedirect.com/science/article/pii/S030881461400692X?via%3Dihub

Red Sage helps reverse liver fibrosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054956/

Beta glucan protects from fibrosis which is found in COPD and NAFLD.

https://www.europeanreview.org/article/8816

Reduces blood pressure.

https://academic.oup.com/ajcn/article/104/6/1534/4564684

https://link.springer.com/article/10.1007%2Fs00125-014-3305-x

Rooibos protects the heart by reducing oxidative stress and by reducing inflammation. Rooibos is also an ACE inhibitor.

https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-017-0200-8

https://www.ncbi.nlm.nih.gov/pubmed/22095883

Tenascan-C is needed for heart repair.

https://www.nature.com/articles/srep04051

https://www.frontiersin.org/articles/10.3389/fphys.2014.00283/full

Tenascan-C is high in COPD

https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-12-48

Tenascin-C is high in tissue injury which is why it is important to address the issues that are causing the injury. Whether it is metabolic issues, nutrient deficiencies, toxins , infection or oxidative stress. This also causes high oxLDL levels.

https://www.e-sciencecentral.org/upload/molcell/pdf/molcell-34-1-35-5.pdf

Fructose and NAFLD, fruit fructose is different it is processed fructose that causes the problem. Just as processed honey loses it’s health benefits so does processed fructose.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372893/

Insulin/Snail1 issues are involve in macrophagy which shows that NAFLD is a macrophagy issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048127/

Macrophagy issue also cause lipogenesis issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108423/

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0450-z

Those with NAFLD have glycolysis issues. This indicates macrophagy issues.

https://www.journal-of-hepatology.eu/article/S0168-8278(13)00362-0/pdf?code=jhepat-site

macrophagy issues have been linked to NAFLD.

https://www.hindawi.com/journals/bmri/2014/120179/

Herbs that help with infection.

 

 

This is not medical advice , I am posting this for educational and informational purposes.

This is a list of things that help with infection. I have literally seen hundreds of studies showing vaccines make pathogens more virulent. Knowing pathogens are going to become more deadly we need to learn how to protect ourselves. Almost all we were taught about germs is wrong. If you read my post on things science has wrong you will see that germ theory and terrain theory are wrong and have been proven to be wrong. Yet almost all modern day science is based on a theory that has repeatedly been proven wrong. This makes most modern day research to be flawed from the start. So we need to seek answers ourselves because if we do not we will not find them because modern science has headed the same direction it often times does in history. It has become corrupted by the greedy and power hungry. This results in the promotion of science that is very very flawed. If you also read my post on it is not your genes it is your gut you will also see flaws in other areas of science. I even discuss how the immune system really works.

I find Buhner’s list of herbs to be the most effective and safest of those I have seen listed.

http://buhnerhealinglyme.com/category/basics/

http://www.pnas.org/content/early/2018/01/17/1716561115

https://www.sciencedirect.com/science/article/pii/S0264410X13015946?via%3Dihub

https://www.asm.org/index.php/asm-newsroom2/press-releases/93495-viruses-you-ve-heard-the-bad-here-s-the-good

Up to 80% of vaccines are suspected of being contaminated with mycospasma. If not treated in time it can lead to many forms of chronic illness.

https://www.prohealth.com/library/mycoplasmas-the-missing-link-in-fatiguing-illnesses-19773

Germ theory is wrong and has been proven wrong many times. So to heal we need to get the crazy ideas they endoctrinated everyone with out of our heads.

https://www.naturalnewsblogs.com/germ-vs-terrain-theory-adopt-healthy/

http://www.laleva.org/eng/2004/05/louis_pasteur_vs_antoine_bchamp_and_the_germ_theory_of_disease_causation_1.html

If possible it is good to breast feed infants, it protects them from infection.

https://www.naturalnews.com/053203_human_breast_milk_drug-resistant_superbugs_antibiotics.html

I do not believe in kissing an infant on the lips. There are valid reasons for this and people get angry when I mention it but the babies depend on us to protect them. What if someone who kisses the baby on the lips has been recently vaccinated. There is a good chance they are carrying a mycoplasma because vaccine have been shown to be contaminated with mycoplasma. Also vaccines have been shown to cause more virulent diseases to form. Those could be transmitted to the infant thus endangering their life.

https://www.top10homeremedies.com/news-facts/why-never-let-anyone-kiss-baby-lips.html

Before treating an infection you should read my post on endotoxemia to avoid developing sepsis.

https://chronicillnessrecovery.org/index.php?option=com_content&view=article&id=161

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059412/

Often times infections can be linked to a vitamin deficiency. For example respiratory infection has been shown in many studies to be linked to a vitamin D deficiency. Now days this could also indicate high mercury or high glyphosate levels because they interfere with our bodies ability to convert vitamin D. In those instances vitamin D3 may help. Do not take excessive amounts of vitamin D. Anything over 4000 IU can cause oxalates to form which are very harmful to the body. I have posted on that.

https://www.bmj.com/content/356/bmj.i6583

https://www.ncbi.nlm.nih.gov/pubmed/29569355

Vitamin D deficiency puts us at a higher risk for getting TB.

https://www.e-epih.org/journal/view.php?doi=10.4178/epih.e2018035

Vitamin A deficiency dramatically increase our risk of infection and immune dysfunction. This is one vitamin we want to achieve homeostasis with though because excess amounts can lead to increased risk of cancer. It is best to try and get your vitamins from food sources when possible.

https://www.annualreviews.org/doi/abs/10.1146/annurev.nutr.21.1.167?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=nutr

Vitamin A deficiency makes us more susceptible to measles.

http://pediatrics.aappublications.org/content/91/5/1014

Thiamine may help with HIV infection.

https://www.ijidonline.com/article/S1201-9712(12)01312-4/fulltext

Those with low thiamine levels have more neurological damage during infection and worse mental outcomes.

https://www.psychosomaticsjournal.com/article/S0033-3182(16)30059-7/fulltext

https://www.hindawi.com/journals/crinm/2018/3901619/

Many nutrient deficiencies have been linked to increased infection especially vitamin B6.

http://www.mdpi.com/2072-6643/8/3/124

Low selenium levels may make us more susceptible to viral infection.

http://www.mdpi.com/1999-4915/7/1/333

https://academic.oup.com/advances/article/6/1/73/4558052

Low selenium status of a mother makes a baby more prone to infection the first six months of life, it also causes a lower neurological development rate.

http://www.mdpi.com/2072-6643/9/5/486

There are instances were minerals will feed microbes for example zinc feeds the pathogenicity of Salmonella.

https://www.ncbi.nlm.nih.gov/pubmed/28874447

I have posted on oxidative stress. Redox homeostasis is very important in preventing infection and the damage caused by infection.

https://www.ncbi.nlm.nih.gov/pubmed/25401329

http://www.mdpi.com/1422-0067/18/11/2459

This is why it is important to get the nutrients needed to support the production of metallothionein.

http://www.mdpi.com/1422-0067/18/10/2197

Cholesterol is needed by the immune system. If we are deficient it can result in immune dysfunction. Since cholesterol is and antioxidant and anti-inflammatory it stands to reason we would suffer ill health effects when deficient in cholesterol.

https://academic.oup.com/qjmed/article/96/12/927/1533176

Cholesterol is needed to produce the hormones we need to protect us from viral infections. This is why if we have issues that cause our production of thiols to be inhibited like high mercury, high glyphosate, high glufosinate or high oxalate levels we need to address them so the body can produce what we need to fight infection.

https://www.cell.com/immunity/fulltext/S1074-7613(17)30074-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1074761317300742%3Fshowall%3Dtrue

https://www.westonaprice.org/health-topics/modern-diseases/the-benefits-of-high-cholesterol/

http://www.ravnskov.nu/2015/12/30/the-benefits-of-high-cholesterol/

We need fats to fight infection. Our cells are made up of a lipid layer. If we do not get enough fat our cells become easier targets for infection.

http://iai.asm.org/content/83/2/514.full

https://www.wjgnet.com/1007-9327/full/v18/i7/627.htm

The types of fats are important. For example Omega 9 and Omega 3 help fight infection. Omega 6 does unless levels get too high. Many diets are too high in Omega 6 causing it to have to opposite effect. Omega 9 is found in the milk and fat from grass fed animals. Grain fed animals have much lower levels of Omega 9 fatty acids. This is also why we should address metabolic issues like pyphoria and pyrrole disorders which effect our bodies proper use of fats. I have posted on those. We also need to address sulfation issues which can lead to problems with our bodies proper use of fats.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831806/

Omega 3 is needed to fight infections.

https://www.sciencedirect.com/science/article/pii/S0923250817300621

Whether we take Omega 3 or not is determined by the type of infections. This does not mean we should avoid it but it means we should limit our intake with certain types of infections.

https://www.journalofinfection.com/article/S0163-4453(16)30252-3/fulltext

For example Omega 3s are very effective against viral infections.

https://www.cell.com/fulltext/S0092-8674(13)00216-X

https://www.sciencedirect.com/science/article/pii/S2090730313000455

Pretty good information on fatty acids.

https://www.healthline.com/nutrition/omega-3-6-9-overview#section1

One of the most potent was oregano. It really helped get my candida bact to commensal form. Not sure why but it gave me indigestion the first couple days. After that I was fine. It fights just about every type of pathogen even fungal.

https://www.organicfacts.net/health-benefits/essential-oils/health-benefits-of-oregano-essential-oil.html

Wild oregano works the best.

http://www.consumerhealth.org/articles/display.cfm?ID=20050530142700

Self Heal helps fight the herpes virus. It also is a helicase inhibitor so would probably help with other viruses also.

https://www.sciencedirect.com/science/article/pii/S0378874104001333?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645367/

Black Sativa is an amazing herb. It fights some bacteria and fungus, it also kill worms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642442/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387228/

List of plants that have antiviral and antibacterial properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439294/

Plants that help with MRSA infection.

https://www.ncbi.nlm.nih.gov/pubmed/27585260

Stinging nettles helps fight MRSA

https://www.ncbi.nlm.nih.gov/pubmed/25395702

Stinging nettles also helps fight the dengue virus, mcyoplasm and many other infectious angents.

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-018-2163-3

https://www.ncbi.nlm.nih.gov/pubmed/23608375

https://www.ncbi.nlm.nih.gov/pubmed/23342511

https://www.ncbi.nlm.nih.gov/pubmed/21738755

https://www.ncbi.nlm.nih.gov/pubmed/18505856

Stinging nettles also fights HIV and the HIV like simian virus found in vaccinations.

http://molpharm.aspetjournals.org/content/74/2/330.long

Dandelion also helps fight dengue virus.

https://www.ncbi.nlm.nih.gov/pubmed/29548293

Biacalein which is found in sculletaria, plantain herb, and fleabane also helps fight dengue virus.

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-12-214

Querciten also helps fight the dengue virus and the flu.

https://www.ncbi.nlm.nih.gov/pubmed/22201648

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-018-2246-1

Evening Primrose helped heal my gut. It has antibacterial and antifungal properties.

https://www.e-sciencecentral.org/articles/SC000007033

http://www.scielo.br/pdf/cagro/v32n2/12.pdf

http://ndnr.com/homeopathy/oenothera-biennis-a-modern-remedy-with-traditional-roots/

https://www.herbwisdom.com/herb-evening-primrose.html

Boneset helps fight the cold and flu. I found it to be extremely effective. I only had to take it for three days. It also helps fight malaria. There is an alkaloid in it and I have not had a chance to research the health effects of the alkaloid so I only use it for about three days. I will not use it any longer then that until I have a chance to research the safety of the alkaloid that is in it. I took it at night because it made me feel like I had a fever and it made me sweat. I decided I would rather sleep through that. Has been shown to be very effective against the flu. Has been shown to be very effective against RNA viruses which are usually the super viruses produced by vaccines. It also fight malaria.

https://www.sciencedirect.com/science/article/pii/S0378874116302793?via%3Dihub

http://klemow.wilkes.edu/Eupatorium.html

http://undergroundhealthreporter.com/boneset-herb-health-benefits/

https://www.thieme-connect.com/products/ejournals/abstract/10.1016/j.homp.2006.06.003

http://www.rjwhelan.co.nz/herbs%20A-Z/boneset.html

Apple leaf has been shown to heal the gut. It kill most pathogens that can harm the gut. It also has many healing properties.

https://www.ncbi.nlm.nih.gov/pubmed/28097143

Hawthorne kills many pathogens that cause gut issues and also is high in mucilage so helps heal the gut.

http://www.mdpi.com/2072-6643/7/9/5361/htm

Wild Basil has antibacterial properties.

https://www.academia.edu/2177104/Antibacterial_Activity_of_Naturally_Occurring_Compounds_from_Selected_Plants

Lemon Balm surprised me. It is known for reducing pain but has very good antimicrobial properties even against viruses including herpes.

https://draxe.com/melissa-essential-oil/

http://herbal-medicine.imedpub.com/melissa-officinalis-extract-inhibits-herpessimplex-virusi-glycoprotein-b-interactionwith-heparin-sulfate.php?aid=9161

https://www.sciencedirect.com/science/article/pii/S0944711308001128?via%3Dihub

https://www.sciencedirect.com/science/article/pii/S2221169115000702

White malberry helps with peridontal diseases. It also helps fight other infections by activating TH1 cytokines. So those who are TH1 dominant would want to avoid this.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897991/

https://foodandnutritionresearch.net/index.php/fnr/article/view/1289

http://www.mdpi.com/1420-3049/23/1/4

Cleavers also known as bedstraw is very effective against MRSA

https://www.ncbi.nlm.nih.gov/pubmed/27585260

Black mustard helps fight malaria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608310/

Galinsoga help fight gut infections. Many bacteria produce urease which raises ammonia levels in the body. Galinsoga inhibits urease which would reduce ammonia levels.

https://www.ncbi.nlm.nih.gov/pubmed/24066513

Virginia Pepperweed is effective against malaria.

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.1210

Vitamin D is very effective at fighting infection. Some who have metabolic issues may have to take D3 if they aren’t converting vitamin D. Excess amounts of vitamin D can cause high oxalate levels. Most do not recommend over 4000 IU of vitamin D a day.

http://healthimpactnews.com/2017/study-vitamin-d-is-more-effective-than-flu-vaccine/

Kudzu has amazing healing properties and also helps fight viruses.

https://www.sciencedirect.com/science/article/pii/S1607551X13001629

Fetid Goosefoot is also good at fighting protozoa infection.

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.1192

Paeonia root helps fight viruses.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121629

Wormwood helps with many types of infections including malaria.

http://www.mrcindia.org/journal/issues/514286.pdf

Baking soda helps with murcormycosis infection.

https://www.diabetes.co.uk/news/2016/may/baking-soda-could-treat-rare-fungal-infection-in-diabetic-ketoacidosis-98341555.html

Coconut Oil helps fight infections including candida and Lyme. It contains monolauren.

https://draxe.com/caprylic-acid/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738477/

Uva Ursi contain berberine which has been shown to very effective against many types of pathogens.

https://www.sigmaaldrich.com/life-science/nutrition-research/learning-center/plant-profiler/arctostaphylos-uva-ursi.html?cm_mmc=SocialSharing-_-Facebook-_-Links-_-/content/sigma-aldrich/global-home/global/en/life-science/nutrition-research/learning-center/plant-profiler/arctostaphylos-uva-ursi

Lyme hides in the lymph nodes. Cleavers is good for getting rid of pathogens in the lymphs. Lyme has so many ways to evade the immune system that I will have to do a separate post on it.

https://www.ucdavis.edu/news/lyme-disease-bacteria-take-cover-lymph-nodes-study-finds

Lyme and other infections can cause alkaline brain.

http://planetthrive.com/2010/12/the-alkaline-brain/

Some things that help fight Lyme.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971593/

Lyme can cause mold illness. This is a good article on how to deal with it.

https://www.selfhacked.com/blog/the-root-causes-of-mold-problems-msh-sirt1-socs3-and-hypoxia/

Golden Rod helps fight gut infections.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979189/

Most species of violet are chemically similar. They have some antimicrobial properties and are very tasty.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613244/

Japanese Honeysuckle has antibacterial and antiviral properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497423/

https://www.hindawi.com/journals/ecam/2015/905063/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923575/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765429/

Cat’s Claw has been found to be effective against many types of pathogens.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384175/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496084/

Moringa helps with urinary tract infection it also has potent antiviral properties.

https://www.ncbi.nlm.nih.gov/pubmed/29175786

https://www.hindawi.com/journals/isrn/2014/906843/

Our commensal bacteria protect us from urinary infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684288/

When things are out of balance some bacteria that protect us will become pathogenic. Science mistakenly list them as pathogens but when our bodies microbiome is balanced they are part of our immune system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988121/

This was a pleasant surprise. One of my favorite foods purslane fights infections.

http://www.mdpi.com/1420-3049/20/9/16375

Plantain herb helps with streptococcus and other infections.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341861/

https://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-41113

Mugwort fights many types of pathogens including mycoplasma.

https://scialert.net/fulltext/?doi=rjmp.2015.234.240

Lactosucrose suppresses H1N1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654070/

NAC inhibits the flu virus but I would take this in moderations. I have noticed when taken daily it seems to lose it’s benefits.

https://www.sciencedirect.com/science/article/abs/pii/S000629520900728X

Red Seaweed helps fight infection.

https://www.frontiersin.org/articles/10.3389/fmicb.2016.00421/full

Do it yourself elderberry cough syrupt.

https://www.instructables.com/id/DIY-Elderberry-Cough-Syrup-and-Tincture/

Red Gensing is a helicase inhibitor which prevents viruses from attaching to cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052424/

https://onlinelibrary.wiley.com/doi/abs/10.1111/jphp.12529

Pau D’Arco helped me a lot. It fights everything from parasites to mycospasma.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585948/

http://www.ndhealthfacts.org/wiki/Tabebuia_avellanedae

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400004

https://www.hindawi.com/journals/mi/2018/9079527/

Vitamin C kills tuberculosis through the fenton reactions. Bad part about that the aluminum and mercury can shut down the fenton reaction and they are found in vaccinations. Glyphosate and glufosinate can also shut down the fenton reaction and they are found in most of our food suppley.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698613/

Probiotics.

Our gut bacteria protect us from infection. The worst part of this glyphosate and glufosinate found in our food supply kill many of our beneficial gut bacteria. Antibiotics and heavy metals can also kill our gut bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337124/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351195/

http://mbio.asm.org/content/5/6/e01817-14.short

https://journals.lww.com/shockjournal/fulltext/2011/07000/Commensal_Microflora_Contribute_to_Host_Defense.11.aspx

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083503/

http://www.jimmunol.org/content/184/12/6782

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572226/

https://www.wjgnet.com/2150-5330/full/v8/i3/117.htm

Our microbiome even protect us from venereal disease and infection.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0107758

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662373/

Our gut bacteria protect our liver.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840232/

Our gut bacteria protect us from food poisoning, unfortunately the BT Toxin in GMOs disable our gut bacterias ability to do this.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198571/

Our commensal bacteria protect our lungs from infection.

http://pediatrics.aappublications.org/content/121/Supplement_2/S115.2

We have to remember our gut bacteria train our immune system.

https://blog.bulletproof.com/how-to-own-your-gut-bacteria-and-fix-leaky-gut-syndrome/

http://www.jimmunol.org/content/198/2/572

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0921-4

We have to feed our gut bacteria.

https://www.newhope.com/ingredients/oligosaccharides-revealing-more-health-benefits

For each pathogen there is it’s commensal counter part which protects us from the pathogenic relative.

http://iai.asm.org/content/77/7/2876.full

Commensal H Pylori.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895553/

We also have phages that protect us from illness but heavy metals, antibiotics, glyphosate and glufosinate destroy them. You can have them replaced but it is very expensive.

https://www.frontiersin.org/articles/10.3389/fmicb.2017.00566/full

Brewers yeast helps protect the good gut microbiota and kills many types of pathogens.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354225/

There are many things that help restore autophagy like nobilene and fulvic acid. Autophagy is a very important part of the immune system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079381/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359130/

I rarely don’t like drugs but Ebselem reduces oxidative stress and kills many types of pathogens including Lyme and mycoplasma.

https://www.sciencedirect.com/science/article/pii/S030441651630068X?_rdoc=1&_fmt=high&_origin=gateway&_docanchor=&md5=b8429449ccfc9c30159a5f9aeaa92ffb

Some things that help with biofilms. Many pathogens form biofilms especially those transmitted by ticks. This makes them drug resistant.

https://www.ncbi.nlm.nih.gov/pubmed/24377137

https://thescienceofnutrition.me/2015/03/13/natural-anti-biofilm-agents/

When sick we have a storm of cytokines that cause inflammation which can lead to sepsis so it is very important to reduce imflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606863/

It is very important to get the inflammation caused by infection and toxins under control because it effects iron homeostasis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108097/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863531/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132657/

https://myersdetox.com/transcript-162-rethinking-iron-supplementation-with-morley-robbins/

Coppers involvement in infecton.

http://www.biochemj.org/content/444/1/51

Inflammation can lead to autoimmunity.

http://www.sciwri.club/archives/4885

https://www.invivogen.com/review-type1-ifn-production

positive emotions helps fight infection.

https://journals.lww.com/psychosomaticmedicine/Abstract/2003/07000/Emotional_Style_and_Susceptibility_to_the_Common.25.aspx

Pathogens use our fat to thrive. Inhibiting phospholipase can help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790186/

Vitamin A inhibits the enzyme used by pathogens which should prevent them from being so pathogenic.

https://link.springer.com/article/10.1007/BF00914275

Some other Phospholipase inhibitors.

https://hal.archives-ouvertes.fr/hal-00637158/document

https://www.hindawi.com/journals/ijb/2015/671562/

https://www.greatplainslaboratory.com/articles-1/2015/11/13/great-plains-announces-new-test-for-phospholipase-a2-pla2-1

Chinese holly protects the lungs from injury from infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041076/

we have to address oxidative stress when fighting and infection I have posted on nitrosative and oxidative stress.

https://www.ncbi.nlm.nih.gov/pubmed/22582501

If the infection and inflammation are not addressed it can lead to gall bladder problems and gall stones.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774219/

I posted on things science has wrong. I had noticed most things they call pathogens have beneficial effects in the body. Some help get rid of toxins, while others help modulate and keep the immune system balanced. Some pathogens even fights cancer. So I kept researching and found when an illness exist then it can harm the pathogen so it has to go into survival mode. When it does that is when it can harm the body. So we much correct the problem to get the said pathogen back to commensal form.

http://www.ener-chi.com/virus-myths-exposed-the-true-causes-of-pandemics/

Endothelins can be high during chronic illness. If they are high we should try reducing them.

https://www.selfhacked.com/blog/endothelins/?utm_source=ActiveCampaign&utm_medium=email&utm_content=The+Latest+From+SelfHacked&utm_campaign=Jan282018+Newsletter

Horsetail helped me a lot with my battle against Lyme but it doesn’t seem effective against many types of bacteria. I notice a lot of improvement in my health when I started using it. It helps fight viral and fungal infection. It is also effective against candida.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920040/

http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_HMPC_assessment_report/2016/03/WC500203421.pdf

https://www.tandfonline.com/doi/full/10.1080/14756360802667688

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100455

Plantain Herb fights gangrene and viral infection.

https://www.sciencedirect.com/science/article/pii/S0166354202000074?via%3Dihub

https://www.sciencedirect.com/science/article/abs/pii/S0753332217322746

https://www.hindawi.com/journals/bmri/2015/286817/

Many plants used by native american has antimicrobial properties.

https://www.ncbi.nlm.nih.gov/pubmed/21054887

Antimicrobial plants used in India.

https://www.hindawi.com/journals/bmri/2015/265425/

Antimicrobials used in Pakistan.

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-122

Golden Rod helps with colds and flu. It is high in betaine also known as tmg so can cause indigestion if taken in excess. It is not mentioned in this link but it stimulates bile production and reduces urinary tract infection. It can aid in digestion if you get that feeling like there is a brick in your gut after eating. It reduces inflammation and symptoms of allergies.

https://www.mountsinai.org/health-library/herb/goldenrod

https://www.herbs2000.com/herbs/herbs_goldenrod.htm

Joe Pye is good for renal infections, kidney stones and gall stones. I know many who used it with good results. There are many who claim it has akaloids that can be toxic but I have not seen the research so I would use it in moderation if you choose to use it.

https://healthyfocus.org/gravel-root-benefits/

http://www.healthy.net/Health/Article/Gravel_Root/1907

http://thenatpath.com/williamson/herb-of-the-day-joe-pye-weed/

Herbs that help with Lyme.

https://www.ncbi.nlm.nih.gov/pubmed/27536352

http://www.tiredoflyme.com/teasel-root.html

Blue Berries help fight food born viruses.

http://trace.tennessee.edu/cgi/viewcontent.cgi?article=4766&context=utk_graddiss

Wild cherry and chokecherry bark fight infection, cancer and heal the gut but can be toxic if over consumed.

https://theherbalacademy.com/wild-cherry-bark-monograph/

Opium lettuce is effective against gram positive bacteria and some gram negative.

https://www.iiste.org/Journals/index.php/CMR/article/viewFile/19073/19317

http://www.ijapbc.com/files/10-01-17/01.pdf

Wild Sarsparilla fights mycoplasma.

https://www.ncbi.nlm.nih.gov/pubmed/26669092

https://www.sciencedirect.com/science/article/pii/S0378874111009263?via%3Dihub

I could list hundreds of studies showing curcumine fights a variety of infections from mycoplasma to viruses. I believe the fact it chelates iron might contribute to it’s effectiveness. If taken for too long it can cause a person to develop anemia.

https://www.sciencedirect.com/science/article/pii/S0166354216307483?via%3Dihub

http://www.jfcmonline.com/article.asp?issn=2230-8229;year=2009;volume=16;issue=2;spage=59;epage=65;aulast=Al-Zanbagi

Many spices are very good at fighting infection.

https://www.herbco.com/t-herbs-infection.aspx

http://ejbio.imedpub.com/antibacterial-effect-of-herbs-and-spices-extract-on-escherichia-coli.pdf

http://www.candida-cure-recipes.com/antifungal-herbs.html

http://www.mdpi.com/1422-0067/18/6/1283

Apple Cider vinegar is very good at killing a variety of pathogens including candida. It also has been shown to be as effective as aspirin against pain. Drinking it straight can damage the digestive system because it is very caustic. I mixed mine with water and a little honey.

https://www.nature.com/articles/s41598-017-18618-x

This is a pretty good list of herbs that fight Candida. But they mention tea tree oil which I would not consume. It can be toxic if consumed too much.

https://www.consciouslifestylemag.com/natural-antifungal-supplements-candida/

Yarrow along with it’s pain killing and ability to make a person feel more positive has many antimicrobial and antiparasitic properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232110/

https://www.researchgate.net/publication/317632510_Pharmacognosy_Phytochemistry_and_Pharmacological_Properties_of_Achillea_millefolium_L_A_Review

http://www.ema.europa.eu/docs/en_GB/document_library/Herbal_-_HMPC_assessment_report/2011/09/WC500115468.pdf

Those whith high acetylcholine levels should avoid calendula. It is a cholesterase inhibitor.

https://www.ncbi.nlm.nih.gov/pubmed/28767066

Calendula and thyme protect from afloxin toxins from mold.

https://www.ncbi.nlm.nih.gov/pubmed/24096837

Calendula also helps fight the common cold.

https://www.ncbi.nlm.nih.gov/pubmed/1965654

Ginger has been shown to have a broad range of antimicrobial and antiparacitic properties it is even effective against respiratory infection.

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402015000200105&lng=en&nrm=iso&tlng=en

https://www.sciencedirect.com/science/article/pii/S0378874112007404?via%3Dihub

https://www.ncbi.nlm.nih.gov/pubmed/29114136

https://www.sciencedirect.com/science/article/pii/S0882401017300815?via%3Dihub

Hibiscus has strong antiviral properties.

https://www.jstage.jst.go.jp/article/jvms/78/9/78_16-0124/_article

Most plants in the sage family have antimicrobial and antiparasitic properties. Red Sage seems to be the best.

https://www.worldscientific.com/doi/abs/10.1142/S0192415X07004709

Colloidal silver is effective against many types of pathogens. You must make sure it is true or pure colloidal silver at least 98% colloidal silver. In some countries they are allowed to sell ionic silver as colloidal silver. As far as I know ionic silver is not toxic but it does cause what they call blue man syndrome. It takes very high does to occur but it is proof the body cannot remove ionic silver. It is very effective against MRSA.

https://draxe.com/colloidal-silver-benefits/

http://www.academicjournals.org/journal/SRE/article-full-text-pdf/78F186B13472

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740956/

http://beforeitsnews.com/v3/health/2012/2444096.html

Beta glucans modulate the immune system helping to normalize it. Many pathogens will cause an over active immune response which helps to stealth them from the immune system. This helps to enhance the immune response to a pathogen. I have posted on beta glucan if you want to learn more.

http://www.mdpi.com/1422-0067/18/9/1906/htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322159/

https://www.omicsonline.org/open-access/bakers-yeast-betaglucan-decreases-episodes-of-common-childhood-illness-in-1-to-4-year-old-children-during-cold-season-in-china-2155-9600-1000519.php?aid=74171

Whey protein increases glutathione in those with HIV.

https://www.ncbi.nlm.nih.gov/pubmed/11168457

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5425915/

https://academic.oup.com/tropej/article/52/1/34/1643836

Lactoferrin protects from viral, fungal and bacteria infections. It is even effective against the Vibrio species.

https://www.jiac-j.com/article/S1341-321X(14)00286-4/fulltext

https://www.frontiersin.org/articles/10.3389/fmicb.2017.02633/full

http://aac.asm.org/content/54/10/4335.long

Lactoferrin combined with the right probiotics helps restore normal bladder bacteria.

https://link.springer.com/article/10.1007%2Fs00404-018-4771-z

Egg whites help fight infections in the same way lactoferrin does.

https://www.ncbi.nlm.nih.gov/pubmed

http://aac.asm.org/content/21/5/840.long

The body will hide iron from some pathogens because it feeds them. Many pathogens have overcome this ability. Lactoferrin has been shown to inhibit those pathogens ability to use iron.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676888/

Rooibos has antibacterial qualities. It really helps me if I get a cold or flu transmitted to me from someone who got vaccinated. Yeah I know they are supposed to be dead pathogens. Why does everyone around someone who has been vaccinated get ill including the vaccinated person? Rooibos also is a strong HIV inhibitor.

https://www.ncbi.nlm.nih.gov/pubmed/24036515

https://www.jstage.jst.go.jp/article/bbb1992/61/2/61_2_267/_article

Rooibos is effective against the flu.

http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/37898/1/ISYK998_Rahmasari.pdf

Some herbs that help with liver flukes.

https://www.ncbi.nlm.nih.gov/pubmed/26695200