High ammonia levels, brain fog, fatigue.

This is not medical advice, I am posting this for imformational and educational purposes.

stomache

 

Hyperammonemia

Homeostasis should always be the goal. If you over do things you can push yourself too far in the other direction and have a whole lot of new problems to deal with.

High levels of ammonia in the body can damage the liver and kidneys. It can irritate the bladder and damage the brain. I person will develop brain fog, they will develop brain swelling because ammonia makes the blood brain barrier more porous. A person will also develop muscle weakness, blurred vision, confusion and possibly demensia. When ammonia levels get very high a person will start developing high glutamate levels. This will cause a head ache that will make your head feel like it is going to split in half. Dysbiosis, high glyphosate or glufonisate levels in the body can cause high ammonia levels. Infections can also increase ammonia levels, especially tick born illness. High aluminum levels causes a disruption in the cycle needed to convert glutamate to GABA. This causes low GABA levels and high glutamate levels. I have posted on the pineal gland which covers detoxing aluminum. Most species of bifido bacteria will produce GABA if they are provided with fiber or Galacto-oligosaccharide. A bacteria found I swiss chees Propionibacterium Freudenreichii produces substances that enhances the growth and health of bifidobacteria.

Most lactobacillus species of probiotic produce lactate which helps reduce ammonia levels. Glacto-oligosaccharide help increase lactobacillus.

Drugs like fluoroquinolones can cause metabolic issues that can cause high ammonia levels.

High ammonia levels also effect our bladder and our digestive system. It changes the ph increasing it. This causes commensal like Candida and H Pylori to go from commensal to pathogenic forms. In order to restore our health we must work on reducing the ammonia levels in our bodies. Metabolic issues can also cause increased ammonia levels. Porphyria, pronteinuria, BH4 deficiency, and upregulated CBS pathway can cause high ammonia levels. Another why that high ammonia can develop is if the bodies ability to metabolize phenylalanine is blocked or inhibited. Low zinc levels can impair the uric acid cycle which can cause ammonia levels to become raised. I found zinc pocalinate helped me a lot.

When a person is suffering from any of those issues high sulfur foods and meat will make things worse. Also consumption of fats will make someone ill if they have high ammonia levels. Medium chain fatty acids are the best to consume when we have those issues. P5P a bioavailable for of B6, magnesium chloride and getting micro nutrients helps reduce ammonia levels. Molybdenum also becomes depleted but should only be taken a few times a week it can become toxic if we over do it. We need selenium I prefer natural sources to prevent getting too much and messing our thyroids up. I eat about 4 Brazil nuts a day. If you have thyroid issues selenium can cause you to react in a way that resembles a food allergy.

High ammonia levels cause neurological damage throughout the body. It will also cause excessive blood clotting and damage to our blood vessels. Bacopa, grape seed extract and hawthorne help prevent that damage.

High ammonia levels can cause high histamines from leaky gut that high ammonia levels cause which can lead to mast cell degranulation which can result in mast cell activation syndrome or mastocytosis. To reduce histamines probiotics that reduce histamines may help. Avoid high histamine foods and fermented foods including most cheese. I have posted on healing the gut. It is very important to address that or you will not get your ammonia levels down. Also take probiotics that reduce zonulin levels, break down ammonia , decrease inflammation and increase T regulatory cells.

Detoxing any chemicals especially glyphosate and mercury is very important and I have posted on that also.

Determining the cause of your high ammonia levels is very important that helps pinpoint what is needed to help correct it.

Things that help the brain heal are mugwort or wormwood they are very similar chemically, sunflower seed lecithin, coconut oil, butyrate found in butter or ghee. Whey protein has glycoprotein that helps the brain heal, fights infection, and improves cell to cell communication. Mushrooms and oatmeal contain beta glucan which fights infection and helps the brain heal.

Reducing the bad gut bacteria and increasing the good is very important in order to reduce high ammonia levels. High ammonia levels can also be a result of gut dysbiosis especially if a person has too many sulfur digesting gut bacteria.

If we do not address high ammonia levels it can increase our estrogen levels and cause high T4 levels causing thyroid problems.

When we have high ammonia levels it causes our breathing to become slow and deep. This is to increase oxygen in the body because high ammonia levels cause a decrease in oxygen in the blood.

If the water we consume has too many nitrates or we get too many nitrite in our bodies it will increase ammonia levels and make a person suffer from oxygen deprivation from the effects on the read blood cells.

Consuming meat can increase the ammonia levels in the body. If too much meat is consumed it does not digest all the way and will ferment in the lower intestinal tract which causes ammonia to be produced.

Lactulose helps reduce ammonia levels in the intestines. It is fermented to lactate which binds to ammonia prevent it from entering the body. Betaine helps reduce ammonia by helping to recycle the enzymes in the body used to break down and convert proteins. Those with PEMT issues should be cautious with betaine (trimethylglycine). Onithine, arginine, yucca root, butyric acid, vitamin C which should be acquired from natural sources also help reduce ammonia. Manganese ad molybdenum help reduce ammonia in the body but should not be taken in high doses and should not be taken for more then a few times a week they are toxic in high levels in the body. Oligosaccharides and inulin help reduce ammonia in the body. Supporting the pathways that are involved with sulfation will help reduce ammonia levels. Magnesium chloride and P5P (pyidoxal 5 Phosphate).

High ammonia levels can cause other metabolic problems which can lead to high ketone levels which can inhibit many metabolic pathways.

Gingko Biloba helps repair the damage in the brain from high ammonia levels but should not be used for more then a couple of months. Many studies I have read show it starts damaging the liver after about two months. The first three days I took it, all heck broke loose because with the improve blood flow to my brain it started to heal. When it started to heal I got pain in my eyes and a bad ache in the front of my head. I continued taking it and after the third day I could feel my mental clarity coming back and I could focus better. Things with biacelin like skuletaria, plantaine herb and fleabane help repair the damage high ammonia causes. Mugwort, coconut oil and other medium chain fatty acids also help the brain to repair. Creatine levels can also become low but I did not have the money to supplement it so I do not know if it would have benefited me or not. Mugwort helps increase GABA. Rooibos tea also helps increase GABA and helps improve brain function.

A person with high ammonia levels may have problems oxidizing fats. Medium chain fatty acids can be readily used by the body which can help promote healing.

Because protein can cause ammonia levels to become low I added glycoproteins to my diet which helped me a lot. I got those from mushrooms and whey protein. We still need to consume some meat. When I had to consume meat I would take protease enzymes like papain, bromelain and beataine with my meal to help increase the break down of the protein thus preventing the build up of ammonia in the gut. I still had to address the metabolic issues.

Though I am not big on drugs rifaximin and neomycin taken together has been shown to help with gut dysbiosis. You will have to take probiotics to replace the good gut microbes. I have posting on taking those. You must do it with caution. Taking too much of one type or taking them too often can lead to gut dysbiosis putting you back to where you started.

High ammonia levels can inhibit autophagy which will contribute to lysosomal issues. This will increase ammonia levels even more. Nobiline and fulvic acid stimulate autophagy but should be used in moderation.

Another problem that can develop is high insulin levels and low glucose levels. I found snacking often helped keep the proteins in my body from being broken down. Most with high ammonia levels have protein deficiencies from the many metabolic issues. I have posted a summary of my notes on metabolic issues and information on things that may help. I would make small shakes with whey protein. You have to make sure they did not add phenylalanine in the whey protein or it will make you worse. Many whey protein shake mixes and proteins and phenylalanine will increase ammonia levels in the body. I also bought bee pollen because it is high in protein and micro nutrients. I added it to my shake. I grow purslaine which has almost all the nutrients the body needs and I added that to my shakes. If I did not have any of those things I would eat carrot sticks or a couple of nuts. I found walnuts helped me the most. Hazlenuts and and pecans helped me a lot but if I ate too many they gave me an upset stomach. Pecans helped me but I could only eat about five of them, anymore then that and I would become nauseated. Brazil nuts helped me a lot but they are high in selenium so I would not recommend more then four or so a day. By preventing our sugar levels from dropping it helps preserve our proteins in our bodies. Once your ammonia levels come down your insulin levels and glucose levels will normalize.

Addressing inflammation is very important because the high ammonia levels causes systematic inflammation. This leads to metabolic issues and can cause and imbalance in the immune system.

I posted on the vitamin D receptor. It becomes inhibited when we have high ammonia levels. Taking Vitamin D is useless unless you address the other receptors that work with the vitamin D receptor this is why vitamin K, vitamin E, Vitamin A and other oil soluble vitamins are important. They must be taken with an oil for the body to absorb them. I used cod liver oil that had lemon juice to prevent it from oxidizing. Cod liver oil contains many of those nutrients. Studies have found that synthetic vitamin C does more harm then good so use natural vitamin D if you take it. Also studies have shown doses of vitamin D over 5000 IU can have a negative impact on our health. Most studies show that taking vitamin D had benefits at first but as it build up in the body it would start negatively impacting our health. I pulsed the vitamin D I took to just maintain levels in my body. I did not take it until I had the other oil soluble vitamins needed.

Antioxidants help reduce the oxidative stress from the high ammonia levels but should be used in moderation once the oxidative stress has been reduced because we need oxidative stress for healing and nutrient absorption. If we reduce reactive oxygen species too low we start losing the ability to heal and to absorb nutrients. Those who have hepatitis need to avoid things that contain resveratrol like grape seed extract because resveratrol activates hepatitis virus. L-lysien, and helicase inhibitors found in the skin or red apples, self heal and lemon balm help with hepatitis and herpes type viruses.

Branched Chain Ammino Acids help restore metabolic pathways and stimulate healing. Whey protein in high in branched chain ammino acids. Though whey protein has to be digested and broken down taking the supplements will help the body more readily absorb them. Eggs are high in BCAAs but many with sulfation issues have problems with consuming high choline foods and may feel ill after eating them. Isoleucine, valine and leucine are the three branched chain ammino acids that could be taken in supplement form.

Calcium-D-Glucarate helps with the brain fog from high ammonia levels. It can be found in the area for urinary tract infections at most pharmacies. Calcium-D-Glucarate also reduces ammonia in the body produced from breaking down protein. Calcium-D-Glucarate also reduces estrogen levels in the body which is often times high in those with high ammonia levels. It also helps the body to reduce toxins.

Bicarbonate rich mineral water can help restore insulin levels and improve blood glucose levels. I could not afford it so I used a tablespoon of baking soda in a glass of water about three times a week and it helped me a lot.

Citrulline helps reduce ammonia in the body but should only be taken a few times a week. If citrulline is taken daily it should be low dose. The liver recycles it and it can build up in the body. If levels get too high it can start causing liver damage and damage to the red blood cells. Citrulline also helps those who have lysinuric protein intolarnce. Those with Lysinuric Protein intolerance may benefit from taking the bioavailable forms of proteins L-lysine, L-argine, L-carnitine and L-ornithine because they are deficient in them. Malabsorption issues can also cause a deficiency in these. If a person is experiencing this their bones may become brittle and they may experience hair loss.

The reason I do not recommend glutamine for those with high ammonia levels is because the liver is usually stressed and it can add to the liver stress.

This is a link to another blog post I did on high ammonia levels just in case I missed something here. https://iamajuicer.wordpress.com/2018/07/13/high-ammonia-levels-in-chronic-illness/

 

https://www.holistichelp.net/blog/candida-sibo-or-h-pylori/

https://drjockers.com/cbs-mutation-low-sulfur-diet/

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0155620

https://www.dovepress.com/hepatic-encephalopathy-current-challenges-and-future-prospects-peer-reviewed-article-HMER

https://www.ncbi.nlm.nih.gov/pubmed/2415874

https://www.ncbi.nlm.nih.gov/pubmed/17006913

http://www.ucl.ac.uk/~ucbcdab/urea/amtox.htm

https://www.ncbi.nlm.nih.gov/pubmed/1505922

https://www.bodybuilding.com/content/bcaas-the-many-benefits-of-amino-acids.html

https://www.ncbi.nlm.nih.gov/pubmed/27582881

https://blog.bulletproof.com/calcium-d-glucarate/

https://drjockers.com/cbs-mutation-low-sulfur-diet/

https://www.hindawi.com/journals/ecam/2015/824395/

http://www.neuroradiologycases.com/2012/02/hyperammonemic-encephalopathy-mri.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101780/#

Advertisements

High Ammonia/Alkalosis Levels in chronic illness.

Ammonia is very toxic to the body and can be formed when there are too many toxins, endotoxins can cause it, vitamin deficiencies, infections, farm chemicals in our food, vitamin deficiencies can cause it and oxidative stress can cause high ammonia levels. When we have high ammonia levels it alkalize our digestive system and our bladder. They are normally acidic. Most pathogens thrive in an alkaline environment. Candida goes from commensal to pathogenic in an alkaline environment and then it will start to alkalize even more. This kills our good bacteria that regulates our gut and bladder PH. I rarely ever fart now I have reach gut homeostasis.

If not addressed it can cause brain swelling.

http://www.neuroradiologycases.com/2012/02/hyperammonemic-encephalopathy-mri.html

Toxins can cause Lysinuric protein intolerance which causes high ammonia levels when protein is consumed. I did a post on proteinuria it should help with this. If not addressed this can lead to copd or NAFLD.

https://ghr.nlm.nih.gov/condition/lysinuric-protein-intolerance

One of the differences between acidosis and alkalosis is that nerves become hyper sensitive in alkalosis and we become excitable. In acidosis nerves are depressed and we become drowsy. Alkalosis is usually caused by fungal infections acidosis by infections that produce endotoxins like Lyme or a viral infection.

http://drbenkim.com/ph-body-blood-foods-acid-alkaline.htm

Symptoms include brain fog, depression, delusions, neurological problems, swelling in the throat, gut dysbiosis, interstitial cystitis or frequent bladder infections, gall stones the list goes on and on.

http://mbio.asm.org/content/2/3/e00055-11.full

https://www.thecandidadiet.com/ph-levels-candida/

https://www.candidaplan.com/10-candida-myths-2/

One of the differences between acidosis and alkalosis is that nerves become hyper sensitive in alkalosis and we become excitable. In acidosis nerves are depressed and we become drowsy.

http://drbenkim.com/ph-body-blood-foods-acid-alkaline.htm

High ammonia levels will cause high glutamate levels which will cause anxiety and many other mental issues.

http://www.ucl.ac.uk/~ucbcdab/urea/amtox.htm

http://onibasu.com/wiki/Elevated_ammonia.html

https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.21357

In acidosis a person will have high plasma potassium levels and in alkalosis they will have low potassium levels.

https://acutecaretesting.org/en/journal-scans/on-the-relationship-between-potassium-and-acid-base-balance

Glyphosate which is found in most of our food causes a mineral imbalance which can cause high ammonia levels.

https://www.frontiersin.org/articles/10.3389/fphys.2017.01083/full

https://www.frontiersin.org/articles/10.3389/fnbeh.2017.00146/full

It can also lead to neuropathy.

https://www.jstage.jst.go.jp/article/internalmedicine/56/11/56_56.8064/_article

http://surgicalneurologyint.com/surgicalint-articles/glyphosate-pathways-to-modern-diseases-iii-manganese-neurological-diseases-and-associated-pathologies/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312745/

Infections especially Lyme can cause high ammonia levels. Ammonia alkalizes and we are supposed to be acidic.

http://planetthrive.com/2010/12/the-alkaline-brain/

Our bladders are supposed to be acidic. Infection can make them alkaline which kills our good bacteria.

https://www.jstage.jst.go.jp/article/jjaam/23/9/23_398/_article

CBS issues can cause high ammonia levels.

https://drjockers.com/cbs-mutation-low-sulfur-diet/

High ammonia levels causes brain swelling.

http://www.neuroradiologycases.com/2012/02/hyperammonemic-encephalopathy-mri.html

Pathogens thrive in an alkaline environment and will cause ammonia to be produced to protect themselves that is why it is important to get ammonia levels down.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677674/

https://www.jstage.jst.go.jp/article/jjaam/23/9/23_398/_article

http://mbio.asm.org/content/2/3/e00055-11

Protein intolerance can cause this. I addressed that in my post on porphyria. Protein intolerance is one symptom of porphyria. It is referred to as phenylketonuria when you eat protein or foods high in phenylalanine you will get sicker.

https://ghr.nlm.nih.gov/condition/lysinuric-protein-intolerance

https://www.mgmjournal.com/article/S1096-7192(05)00238-6/fulltext

Supporting the BH4 pathway to correct phenylketonuria is very important. It is one of the causes of autism.

http://journals.sagepub.com/doi/full/10.1177/2326409816685734

https://autismmasterycourse.com/wp-content/uploads/2016/08/Neurochemical-Imbalances-and-Autism-Tetrahydrobiopterin-Metabolism-and-Quinolinic-Acid-Toxicity.pdf-8-15-16.pdf

If you have a blocked or upregualted CBS pathway , or an upregulated BH4 pathway and don’t address it this could make you ill. Most with those issues would benefit from taking P5P, selenium, and magnesium citrate. Also three times a week molybdenum and manganese. Do not use magnesium citrate more then twice a week. The body recycles it and it can build up in the body and start causing liver and kidney damage and destroy red blood cells. Citrate also reduces oxalates. 

https://www.uofmhealth.org/health-library/hn-1247002

http://www.detoxpuzzle.com/bh4.php

If not addressed you can have seizures,depression, difficulty swallowing and many other problems.

https://www.medicinenet.com/tetrahydrobiopterin_deficiency/article.htm#what_are_the_symptoms_of_tetrahydrobiopterin_deficiency

https://www.selfhacked.com/blog/tetrahydrobiopterin-bh4-role-body-buy/

http://www.beyondmthfr.com/mthfr-depression-folate-bh4-connection/

It is very important to address the things that cause nitrosative and oxidative stress. Things like inflamation, nutrient deficiencies, infection, metabolic issues. They both can cause high levels of ammonia.

https://www.sciencedirect.com/science/article/pii/S0197018612003506?via%3Dihub

https://www.sciencedirect.com/science/article/pii/S0003986113000982?via%3Dihub

The liver and kidneys are important for detoxing ammonia. These herbs really help. Remember homeostasis is he goal. Do things in moderation.

https://www.cancertutor.com/faq_liver_damage/

https://www.selfhacked.com/blog/liver-health-foods-supplements-good-bad-liver/

https://www.drweil.com/health-wellness/body-mind-spirit/liver-kidney/boosting-kidney-function/

https://www.globalhealingcenter.com/natural-health/10-best-herbs-kidney-cleansing/

We need glucose found in fruits and vegetables and even honey, maple syrup and organic unsulfured blackstrap molasses to keep ammonia levels down.

https://www.physiology.org/doi/10.1152/ajpgi.00437.2002

http://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-13-2-177

http://www.pnas.org/content/108/27/11121

Issues with our CBS pathway could also cause high ammonia levels. Anything that causes high sulfite levels can cause high ammonia levels. Gene mutations only present when there are many things wrong, once I got my ammonia levels and sulfite levels down I could start consuming high sulfur foods again. I still take the nutrients once in a while to support those pathways so it does not become a problem again. Glyphosate also effects the pathways negatively so we should try our best to eat organic. Also if we have gut dysbiosis then we need to address that because that raises our sulfite and hydroxy radical levels which also causes high ammonia levels.

https://www.drlam.com/blog/a-cbs-mutation-could-be-causing-your-health-problems/34861/

https://drjockers.com/cbs-mutation-low-sulfur-diet/

https://metabolichealing.com/metabolic-gateways-cbs-gene-mutations-glutathione/

https://hubpages.com/health/How-to-lower-ammonia-for-those-dealing-with-A1298-NOS-SUOX-and-CBS-mutations

If we have an infections the endotoxins effect these pathways which will raise ammonia levels so we need to detox endotoxins which I covered in my post on how to recover from endotoxemia.

http://www.tiredoflyme.com/ammonia-a-lyme-disease-exotoxin.html

Gut dysbiosis causes high ammonia levels, from the high sulfite levels. This effects the brain.

http://drstephaniedavis.com/gut-dysbiosis-making-sick/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259177/

This adds to the problem because high sulfite levels keeps the good gut bacteria from reestablishing.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646858/

http://altmedrev.com/archive/publications/9/2/180.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508456/

https://www.badgut.org/information-centre/a-z-digestive-topics/the-role-of-sulphur-in-uc/

Bismuth which is what Pepto Bismo is , reduces sulfide levels.

https://www.ncbi.nlm.nih.gov/pubmed/9558280

https://www.thesibodoctor.com/2017/12/20/sibo-and-hydrogen-sulfide/?v=7516fd43adaa

Not getting enough cholesterol, high sulfite level, and oxidative stress can inhibit bile production. This make H Pylori go from commensal to a pathogenic form. Bile helps detox ammonia from the body. If it feels like a brick is in your stomach after you eat and you get gassy then you have low bile production which will lead to low stomach acid production. Your food is fermenting instead of being digested which will also cause high sulfite levels and high ammonia levels.

https://link.springer.com/article/10.1023/A:1010678210019

https://metabolichealing.com/l-glycine-brain-gut-tissues/

Low bile will inhibit our ability to break down fats which are needed by the body.

http://askanaturopath.com/faqs/low-bile-salts/p/712

https://www.liverdoctor.com/gallbladder-and-digestive-problems/

Things that increase bile.

http://healthyeating.sfgate.com/foods-increase-bile-flow-8649.html

https://metabolichealing.com/unclogging-the-liver-advice-ideas-for-one-of-the-most-vital-and-massive-organs/

https://drjockers.com/25-ways-improve-gallbladder-health/

Taurine helps increase bile productions.

http://www.jlr.org/content/28/9/1021.long

Butyrate produced by our gut bacteria protect the gut and the gut bacteria. When we are low in butyrate our gut becomes inflamed. I ate butter or ghee which is high in butyrate. Our butyrate producing bacteria even regulate our metabolism.

https://www.sciencedirect.com/science/article/pii/S2405654517301397

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517538/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099420/

Zinc helps reduce ammonia levels.

https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.1840160326

Calcium D-Glucurate helps reduce excess ammonia.

https://blog.bulletproof.com/calcium-d-glucarate/

Bicarbonate rich mineral water will reduce ammonia.

https://www.hindawi.com/journals/ecam/2015/824395/