This is not medical advice I am posting this for educational and informational reason only.
There are two sources of histamines endogenous and exogenous. Endogenous means from within or internally so is produced inside the body. Exogenous is introduced to or produced from outside the body. There are health issues with high or low histamines. Narcolepsy is in it’s own class it alternates between high and low histamine.
Histamine has many functions in the body , it is involved in the immune response, regulating physiological function in the gut. It acts as a neurotransmitter in the brain , spinal cord and uterus. It is involved in inflammation and the itching we feel. Histamine is produced by basophils and mast cells types of white blood cells. Histamines increases the permeability of blood vessels to allow white blood cells and some proteins to pass through so they can to engage pathogens in infected tissues.
Histamines generated in granules in mast cells and basophils. Most cells are more numerous in sites of the body that is more prone to injury like the mouth , nose, internal body surfaces and blood vessels. Non mast cell histamine in found in areas such as the brain. Another site of histamine storage and release is in enterochomaffin-like cell (ecl). This is an area in the gastric mucosa. Because of histamines properties it is versatile and able to interact and bind more easily.
The most important role of histamine is immunologic. When the mast cells or basophils have been sensitized to a pathogen by IgE antibodies that attach to their membranes will degranulate when exposed to the appropriate antigen. Certain amines, alkaloids found in plants can displace histamine in granules and cause their release. The break down of amino acids releases amines which are higher in aged meats. Lowering IgE can reduce histamine release.
Histamine is involved in anaphylaxis. Anaphylas is a rapid onset allergic reaction. It can involve itchy rashes, throat and tongue swelling, shortness of breath, lightheadedness, vomiting and low blood pressure. Sometimes they develop over hours. Vaccinations and toxins in our environment and food are known causes of a person developing allergies.
Histamine gated chloride channel is said to be expressed in the hypothalamus, thalamus, and intestines. It has synaptic inhibitory effects. It inhibits the GABA receptors making us more awake. It is also involved in diarrhea.
Histamines are the cause of runny noses. Increased vascular permeability caused by histamines causes fluid to leak from the capillaries into the tissue which leads to runny nose and watery eyes. Allergens can bind to IgE-loaded mast cells in the mucous membrane. This is what causes the sneezing, hyper secretion from glandular tissue, and congested nose from the vasodilation increasing the size of the blood vessels.
Histamine is a neural transmitter that is released from histamine neurons in the hypothalamus (hypothalamus links the nervous system to the endocrine system via the pituitary gland.) . These cells are located in a part of the hypothalamus known as tuberomammilian nucleus. The tuberomammilian nucleus consist largely of histamine neurons and is involved in sexual arousal, learning, memory, sleep and energy balance. The nuerons in this area comprise the brain’s histamine system. It contains nerve fibers that connect it to other areas of the brain.
Enterochromaffin-like cells located within the gastic glands of the stomach that stimulates a certain type of epithelials cell by binding to the end of the H2 receptor. Stimulation of the pariental cells (stomach epithelial cells that secret hydrochloric acid) induces the uptake of carbon dioxide and water from the blood, which is then converted to carbonic acid by the enzyme carbonic anhydrase. Inside the cytoplasm of the pariental cell the carbonic acid readily disassociates into hydrogen and bicarbonate ions. The bicarbonate ions diffuse back through the basilar membrane and into the blood stream while the hydrogen ions are pumped into the lumen of the stomach via specialized pumps. Histamine release is halted when the ph of the stomach starts to decrease. Certain drugs contain antagonist molecules that block the H2 receptor and prevent histamine from binding causing decreased hydrogen ion secretion. Antagonist is a type of receptor ligand that blocks or dampens biological response by binding to and blocking a receptor.
Though histamines have stimulatory effects on neurons it also has suppressive effects against the susceptibility to convulsions, and lesions in the brain.
Those with schizophrenia have increased histamine metabolites in their cerebrospinal fluid and the efficiency of the H1 receptor binding sites is decreased. This can be caused by the toxins in vaccinations, farm chemicals found in our food, heavy metals or inflammation.
Seeing all that histamines do demonstrates the importance of histamine homeostasis. To much can cause many health problems and if inhibited it can cause many health problems. Now knowing the types of histamine receptors will help identify where a specific problem may be. This helps identify the most probably cause of the health problems. For example vaccinations damage certain areas in the brain that that could effect the histamine receptors in our brain that effect our sleep and wake cycle. BT Toxins and the farm chemicals used on them cause leaky gut which can effect histamines throughout the body. Identifying the areas effected by histamines helps narrow the cause down. If you read studies on those who take frequent antihistamines they eventually develop autoimmune disorders which shows the importance of achieving homeostasis so once you have reach homeostasis you should work on maintaining it. Many over do things by continuing the same protocols even those the problem has been corrected which ends up creating other problems.
There are four types of histamine receptors H1-H4.
H1 is expressed in the central nervous system (brain and spinal cord). It is involved in the sleep wake cycle. It promotes wakefulness. It is involved in body temperature regulation, hormone regulation, it can simulate appetite, it constricts the airways, it can increase the sensation of pain, especially in the pelvis and stomach. It can also cause uticaria and itch perception.
H2 is expressed in the central nervous system, stomach, mast cells, vascular smooth muscle cells, cells in the heart and uterus. It has very few effects on the brain, most H2 receptor ligands cannot cross the blood brain barrier. Primarily involved in vasodilation and stimulation of gastric acid and appetite.
H3 Located primarily on basophils in the bone marrow, thymus, spleen and intestines. Plays a role in mast cell chemotaxis (movement cells in response to a chemical stimulant), sensation of itching, cytokine production and secretion, heightened pain in inner organs, involved in inflammation and allergies.
Some H1 agonist can cause drowsiness while H3 agonist can cause wakefulness.
In some illnesses T Cells attack the bodies own cells. H1 and H4 make the symptoms worse will H2 and H3 decrease the symptoms. They believe it is because H2 and H3 help with T Cell differentiation in the immune system. So this would help differentiate between our own cells and a pathogens, preventing the immune system from attacking it’s own cells.
Since histamine are an important part of the immunes system disorders involving histamines can have effects on our immune system. Things like mastocytosis and mast cell activation syndrome. They have some differences but the remedies for them are pretty much the same so I will probably just say mast cell disorders. They are caused by excess mast cell degranulation. Many of these illnesses they claim are genetic but they are finding it is the gut bacteria that modulate those genes that are inherited or that a person may be lacking. Also gene mutations usually do not present themselves unless many other things have went wrong. To reach homeostasis you have to address any other health issues especially leaky gut. When you have high histamines and your nose runs it will be clear or white colored. When it is from and infection it will be different it will be darker colored, I have seen green, brown when the infection is in the tissues, I have even seen yellow.
Anaphylaxis is caused by mast cell degranulating.
Histaminosis is a disorder that is caused by a shortage of the enzymes that break down histamine. Diamine Oxidase and Histamine N-methyltransferase.
Diamine Oxidase (DAO) known as histiminase is an enzyme involved in the metabolism, oxidation and inactivation of histamine and other polyamines. Poly amines are found in aged meats and fermented foods. The highest levels of DAO are found in the digestive tract and placenta.
Histamine N-methyltransferase also reduces histamines. The Cytochrome P450 enzymes are involved. Glyphosate inhibits CytP450 Ezymes which raises histamine levels. This is also why it is very important to address inflammation because that can inhibit detoxing.
A deficiency in these enzymes can lead to asthma.
Our gut bacteria can add to the histamines causing asthma , we need to increase our histamine digesting microbiome.
When levels are low it effects our sleep and we become aggressive.
Also our gut bacteria reduce histamines.
We must heal our guts
The above mentioned conditions can be set off by toxins like heavy metals and farm chemicals which are found in our food especially glyphosate. It can be set off by pathogens especially Lyme disease. Excess inflammation can increase the risk of these happening along with oxidative stress.
DAO deficiencies and high histamines.
Symptoms of mastocytosis are anaphylaxis, low blood pressure, hives and swelling, itching, nausea or vomiting, diarrhea, fainting, headache, uterine cramps, bleeding, flushing, and muscoskeletal pain.
Test for mastocytosis.
Symptoms of Mast Cell Activation Syndrome are flushing, hives and swelling, nasal itching and congestion, wheezing and shortness of breath, throat itching and swelling, headache, brain fog, cognitive dysfunction, mental issues like anxiety or depression, diarrhea, abdominal pain, bloating, GERD, bone and muscle pain, lightheadedness, rapid heart rate, low blood pressure, uterine cramps or bleeding.
POTS caused by myocarditits can be caused by mast cell activation.
Symptoms histaminosis most commonly known as histamine intolerance can manifest as intolerance to sulfur, food sensitivities especially gluten, gliaden, and milk products., sensitivity to amines found in aged meats and fermented foods. Gastrointestinal issue, excessive gas, diarrhea, cramps, fatigue, insomnia, noise sensitivity, hives, hypertension, and depression.
Fluroquinolone causes mast cell activation.
Can Fluoroquinolones Activate Mast Cells?
The whole body is effected by mast cell activation.
High estrogen and low progesterone can cause high histamines. Many toxins like glyphosate and BPA can cause this.
When you have problems with histamines it is very important to adjust your diet to reduce histamines and amines. Once you reach homeostasis you can slowly reintroduce them back into your diet. Because most of the solutions for addressing the various disorders overlap I won’t mention which disorder it helps because for the most part all will be helped by the things mentioned. Do your research to be better able to develop a protocol unique for you. We are all different and can not do a one size fits all protocol. Most of these symptoms can be caused by gut bacteria imbalance or leaky gut.
Lectins, leaky gut and histamines.
Specific diets like the paleo diet should only be used until the problem has been corrected.
Melatonin reduces histamines.
Vaccinations cause allergies and getting the measles protects against allergies.
Genetically modified foods increase amines similar to those caused by food poisoning. This would cause gut issues and a rise in histamines.
Luteolin prevents mast cell degranulation.
Tick born illness can induce mast cell activation.
Caffeic Acid reduces histamines. Caffeic acid is high in beer, whole wheat, rye, plums, dates, berries, peaches, apples, olive oil, sage, thyme, oregano,nut , vinegar and corn. They must be organic because the BT Toxin in GMOs will make the body produce histamines.
I find it interesting that GMOs kill the gut bacteria that help with Serotonin production and many with mastocytosis have low serotonin levels.
This is MTHFR and histamines. Genes that cause issues usually don’t present unless there are other health problems. Addressing them will usually correct the problems then take action to support the offending genes. If you read my post on “It is not your genes it is your gut microbiome” you will see many things that are supposedly gene mutation are actually a lack of gut bacteria that modulate those genes.
Histamine degrading enzymes and their cofactors.
Histone inhibitors may stop gene expression that may be causing mast cell activation.
Falcarinol a cannabioid found in carrots, celery and other plants that are related reduces allergies.
Strategies to reduce run away mast cells.
Quercetin reduces mast cell activation.
Because our food has been found to contain glyphosate we should avoid GMO and foods that contain it. Try our best to eat organic.
When H Pylori is commensal it protects us from allergies.
Rehmannia reduces mast cells.
If we do not address histamines and inflammation it can lead to autism.
When we have an infection histamine levels go up so getting the pathogen load down is very important.
High homocysteine can increase inflammation which can raise histamines.
Raised histamines leads to arthritis.
Raised histamines can cause adrenal fatigue.
purslane reduces histamines.
Things that increase DAO to decrease histamines. Some are high sulfur foods and if you have high sulfite levels , CBS, or BH4 and have not addressed it you will make yourself worse.
Naturals for reducing histamines.
Food additives increase inflammation and histamines.
High histamines contribute to Chronic Fatigue and fibromyalgia
Vaccinations and GMOs cause leaky gut which causes high histamines.
We cannot reduce oxalate entirely but would should reduce them. Most oxalates are formed inside the body so it is best to correct the problem causing them. Also leaky gut will leave oxalates enter the body.
Reducing mast cells helps with diabetes and obesity.
There is a lung list of illnesses caused by mast cell activation from fibromyalgia to interstitial cystitis. Mast cells release trypase and it has been found to be high in interstitial cystitis indicating that mast cell activation is and issue in interstitial cystitis.
Those with mast cell activation do not always develop skin problems which is often used to diagnose it.
Drugs for mast cell activation. Drugs treat the symptoms so I would work on the cause while you hold the symptoms at bay.
Mast Cell Activation increases our risk of cancer.
High IgE levels and high mast cell activation do not always coincide with each other.
I put three drops of tea tree oil in 8 ounces of jojoba oil it helped me skin inflammation and rashes a lot.
Hydroxyurea helps with mast cell activation.
Food sensitivities and mast cells.
Mast cells can protect the nerves or damage them. That is why homeostasis is important.
Vitamin E which is high in olive oil and fish oil stabilizes mast cells.
Vitamin D3 helps reduce mast cell activation but in doses higher then 4000 IU it can cause oxalates to form. That is why life guards have the highest incidence of kidney stones because our bodies make vitamin D when sun light hits our skin.
Honeysuckle has many benefits including reducing allergies.
Mast cell activation can cause high IL 17 levels which can cause Lupus and COPD.
Mast cells can be an indicator of toxins.
Mercury and mast cells cause brain deterioration.
A disruption in the endocanabinoid system can cause allergies. But there is a big scam people believe that cannibus is the only source of cannabinoids and that is not true many plants have them and each has it’s own unique benefits. Big corporations own the cannabinoid crops though so you will not hear about the other cannabinoids that often times have more healing benefits.
We have to cover both side of the coin. Histamine deficiency can also cause health problems. It is why once we achieve homeostasis we should work towards maintaining it and not continue with the protocols that may inhibit it. We could cause other health problems by pushing things in the opposite direction.
This site give the symptoms of histapenia, it mentions to take folic acid. Do not take it, it is man made and damages the body. Folate is natural and does not harm the body, I do not know why but many medical professionals do not know the difference between folate and folic acid.
Any ways the symptoms of low histamine levels are inhibited immune system, elevated serotonin, elevated dopamine, elevated norepinehrine, and low histamine. Low basophil levels, food senstivities which is not the same as food allergies, difficulty digesting food, anxiety, low libido, becoming obssesed with things, paranoia, auditory hallucination, hyperactivity, delusions of grandeur, excessive sleepiness. It can be caused by overmethylation. With low histamines the nose can be dry and you may get nose bleeds.
Histamines help prevent cancer, inhibiting histamines can make us more prone to cancer.
Autophagy is how the body recycles chromosomes. When we are deficient in histamine it can damage the heart by inhibiting autophagy.
H2 inhibitors cause vitamin B12 deficiency.
This is an article on decreasing histamines but talks about things that raise histamines so could be used to figure out how to raise histamine levels.
Narcolepsy is in it’s own class it alternates between high and low histamine. Narcolepsy has low orexin levels which cause this.
Increasing orexin helps with narcolepsy.
High sulfite levels can cause mast cell degranulation which results in high histamines. Gut dysbiosis, candida, endotoxins, mercury, glyphosate or anything else that inhibits sulfation can cause high sulfite levels.
You can see histamines could be a sign of autoimmune disorder. These link explains some basics on histamines.
Autism shows the same markers as an autoimmune disorder. Vaccinations cause autoimmune disorders and many people are compensated for it from the vaccine injury compensation fund.
Tick born illness, fungul infections and mycoplasma which most vaccinations have been found to be contaminated with can cause high histamines.
Metabolic issues can cause induce asthma by raising histamines.