Why those with Lyme disease get so ill.

I am writing this to show why people get so ill with Lyme disease. Lyme infection rarely occurs on it’s own. Most insects that transmit Lyme carry other infectious diseases. Lyme disables the immune system making it difficult to clear out any type of infection. Lyme also has many ways of evading the immune system. It can take a variety of forms such as cyst or biofilm to protect itself from the immune system and antibiotics. Lyme disease has developed strategies to avoid almost all the things used by our immune system to fight infection including hydrogen peroxide. Lyme even infects the lymph’s and disables their ability to detect infection. Lyme has more methods of evading the immune system then the virus that causes HIV. Most who have Lyme disease experience Bell’s Palsy. This is where one side of the face become paralyzed and drops. It sometimes takes months to heal.

This is a good article that gives a small summary of just some of the things Lyme can do.

BORRELIA BACTERIA

Something to take note of the test for Lyme disease has a very high failure rate at detecting it. Not only that there are a variety of species of Borrelia and as far as I know the test only test for one so if a person has any of the other species of Lyme disease the test will not detect it. Also those infected with Lyme are rarely test for the coinfections which are almost always present when the infection occurs.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963229/

Lyme causes systemic inflammation. Systemic inflammation also inhibits the immune system and can cause the body to turn on itself. Lyme can cause a variety of symptoms such as joint swelling, neurological issues, brain damage, myocarditis, thrombosis, organ failures and many other health issues. The systemic inflammation caused by Lyme disease damages the heart in many ways which reduces it’s ability to supply blood to the body. This is why often times those with Lyme will experience numbness in hands and feet. When left untreated death can occur. This is so common with Lyme disease that if a person experiences Bell’s Palsy then they should find a medical professional to treat them that is very knowledgeable about Lyme disease and the coinfections that occur with it. Sudden temperature changes often times can set Bell’s Palsy off or make it worse.

Lyme can damage the joints in a variety of ways. Lyme can cause high ammonia levels which lead to metabolic issues which causes soft tissue to break down in the body. Lyme can cause synovial fluid to build up in the joints and could cause them to eventually start leaking. Lyme can also break down the soft tissue in the joints and body causing fluids to leak into surrounding areas which causes joint swelling and arthritis. Lyme cause high urease levels which can lead to gout. Some suffer from more then one of those. Lyme also causes bone loss in some.

Lyme disease can cause autoimmunity . A person with Lyme can experience autoimmune issues that cause them to develop many food intolerances, they could develop things such as Lupus, Psoriasis or interstitial cystitis among many other autoimmune related illnesses.

Lyme damages the heart and cardiovascular system in a variety of ways. Many Lyme sufferers are learning from experience that many medical professionals and cardiologist do not know how to identify the cardiac issues caused by Lyme. Sad when those who have become ill learn to read test better then those who are supposed to know how to interpret the results of test but experience has taught many of us that they rarely know how to interpret the results of test accurately. Lyme can cause damage to the blood vessels and cause excess blood clotting. The excess blood clotting if not addressed can lead to stroke, heart failure and death. Many push themselves too hard when they start feeling better and will set themselves back in their healing for weak. I myself made this mistake many times before I learn to only do a certain amount and to slowly increase the stressors in life whether physical or emotional because emotional stress can often times take more of a toll on the heart then physical stress.

Lyme can cause brain damage and other neurological damage. My experience has shown my that people are very resilient. I have seen many maintain their composure even though the Lyme was effecting their brains especially their memory they still seem to maintain their composure and not react to the variety of emotions that occur while they are very ill. Not only that but Lyme causes pain beyond anything a person can imagine. I have learned this from personal experience and that takes it toll on the body by draining all our energy and it often times takes a lot of mental resources to deal with the pain a person with Lyme is experiencing.

Most have Lyme disease and do not know it. A large number of those suffering from interstitial cystitis go many years having Lyme disease and never get diagnosed because of the high failure rate of the test at detecting Lyme. Because Lyme takes so many forms and has many ways to stealth itself from the immune system the body may not have an immune response to the spirochete so a person can go for years with Lyme disease and the test will not detect it. Many who have lyme disease develop liver , kidney , bladder , gall bladder and many other health issues. Most I know who had Lyme disease found urinating was very painful.

Lyme disease also alters B cells status which effects the gut and can cause gut dysbiosis leading to leaky gut, inflammatory bowel disease, diarrhea or constipation. This article summarizes what can happen to the gut when you have Lyme the things that can occur are complex and would take a whole separate article to discuss. The second article has links to research showing how Lyme effects the gut.

Gastrointestinal Symptoms of Lyme Disease

https://www.publichealthalert.org/palsy-of-the-gut-and-other-gi-manifestations-of-lyme-and-associated-diseases.html

Lyme causes autoimmunity through molecular mimicry. It mimics proteins in the body. If the body detects that the protein is actually an infection then it will start attacking it. Because it is similar to proteins that are in the body it causes many types of autoimmunity from mast cell activation syndrome, to diabetes and cardiovascular disease. Many infections can cause autoimmunity if systemic inflammation from a toxin or a drug has already occurred. Once this occurs it creates a positive feed back loop that is very difficult to break. These are the symptoms and illnesses that Lyme autoimmunity can cause. Myocarditis, thrombosis, erythema migrans, lyphocytoma, plexis nueritis, cranial nueritis, Bell’s Palsy, endotoxemia, hyperammonemia, proteinuria, gut dysbiosis, leaky gut, inflammatory bowel disease, interstitial cystitis and other renal diseases, Bannswoarth’s syndrome, muscular dystrophy, ALS, fibromyalgia, arthritis, dissassociative disorder, chronic fatigue syndrome, disease that are caused by lesions in the body including Parkinson’s , cancer, myositis, acrodermatitis and many other skin disorders including Lupus, loss of fluids from the joints causing them to leak into the surrounding areas, depression, irritability, mental confusion, memory loss, polyneuropathy encephlomyelitis, memory deficit disorder, somnolence (excessive sleeping), adrenal fatigue, some will go the other way and will have difficulty sleeping, I alternated between somnolence and insomnia, anorexia, flu like symptoms that will not go away, night blindness, sensitivity to light which causes a person to be easily blinded by light, and nerve palsy. These are the symptoms and health issues I have seen occur the most though Lyme causes many other health issues.

The severe headaches caused by Lyme can be caused by many things. Lyme can enter the brain and cause meningitis, Lyme causes high ammonia levels which damages the blood brain barrier leaving excess glutamate enter the brain which can effect the NMDA and leaving toxins enter the brain that would not normally enter the brain. The endotoxins from Lyme itself can cause the blood brain barrier to become porous leaving it enter the brain causing brain inflammation and effecting many receptors.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409434/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320932/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963551/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489802/

https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1381-4

https://www.nejm.org/doi/full/10.1056/NEJM199401273300401

https://www.jrheum.org/content/46/8/871

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278181/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679706/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336510/

https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1381-4

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206025/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165408/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151210/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477530/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963229/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054245/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851570/

Chronic heart failure.

https://academic.oup.com/eurheartj/article-abstract/12/suppl_D/73/398738?redirectedFrom=fulltext

http://www.ajtmh.org/content/journals/10.4269/ajtmh.1992.47.249

https://link.springer.com/article/10.1007%2Fs00508-014-0622-5

https://www.bioscience.org/2003/v8/s/1065/fulltext.htm

https://sites.google.com/site/virginialyme/treatment/lyme-babesia–hypercoagulation

https://idsa.confex.com/idsa/2003/webprogram/Paper18421.html

Hypercoagulation in Lyme Disease

Lyme and the renal system and IC.

https://pubmed.ncbi.nlm.nih.gov/8417211/

https://pubmed.ncbi.nlm.nih.gov/26664404/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797892/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076487/

Lyme and digestion

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496901/

Lyme autoimmunity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548028/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800627/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800627/

https://www.sciencedirect.com/science/article/pii/S1198743X14628871

Those Not helping the ones effected by chronic illness will not be helped on God’s great day of judgment.

Written by Lee Stevenson. Sorry I did not edit it but I am very busy trying to figure out how to find a source of income, I have been trying to find a way to make money with my limited resources so I do not have much time for editing.

Vaccine injury, Lyme disease and chronic illness from the BT Toxins and glyophosate used in GMOs are the most common forms of chronic illness now days but Lyme sufferers are the most looked down on and most discriminated against. As they judge us they also will be judged on Gods great day.

(Matthew 7:1-5) 7 “Stop judging that you may not be judged; 2 for with the judgment you are judging, you will be judged, and with the measure that you are measuring out, they will measure out to you. 3 Why, then, do you look at the straw in your brother’s eye but do not notice the rafter in your own eye? 4 Or how can you say to your brother, ‘Allow me to remove the straw from your eye,’ when look! a rafter is in your own eye? 5 Hypocrite! First remove the rafter from your own eye, and then you will see clearly how to remove the straw from your brother’s eye.

Lyme needs systematic inflammation to take out the immune system. Our environment and food is so toxic that it is causing systematic inflammation in people. The OspA is a funfal antigen that is used in bioweapons, vaccinations and many pathogens have somehow developed the ability to produce a variety of outer surface proteins that are similar to the OspA fungal antigen. My question is how did they suddenly develop this ability? Now add this with the well known fact vaccinations also cause systematic inflammation and you can see why so many are developing chronic illness from tick born disease. Ask yourself what has changed to cause so much chronic illness now days? Now I am going to describe what I experienced.

Fortunately we have Carl Tuttle on our side and his pursuit of justice and fairness is relentless. He does not let up. I am glad he is on our side and not theirs. I would not want to be on the opposing side of him. He is thorough with his research and knows what he is talking about. He has been amazing. Those suffering from mysterious illness that they cannot explain should read this. This is a medical professional describing her experience in getting diagnosed and treated for Lyme disease.

https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf/u/23804038?cs_tk=Aa50gapTNyDGCxZmN1wA-1Zm1fmnEl69rt_9r7wtrA%3D%3D&utm_campaign=9fe2604cf8a245db9d0c28c6047d9430&utm_medium=email&utm_source=petition_update&utm_term=cs

If you do not have Lyme you are one insaect bite, or one sexual partner away from your life being destroy. There are many methods Lyme can be transmitted. You can carry it for decades then one vaccination, too many GMOs or too many toxins and you will experience what this medical professional did. They first try to prescribe Psych meds. Then they ignore you and tell you not to come back to their office you have to jump from one doctor to another and all of them will do the same exact things. This woman had a lacerated meniscus and swollen knee. This was my first symptoms and happened exactly like it happened to her only when they went in to repair my meniscus they discovered weird calcium deposits on my muscles and ligaments. they removed them and my muscle spasms went away for a while and I could use my leg. Then slowly this started happening throughout my body.

Then over the years different joints including my fingers would swell and get very sore. They told me I had gout or arthritis. All doctors had the same reactions when the test come back negative for both. So their next reaction was because I believe something was wrong with my body I was imagining things and it was causing my body to react this way. So again they tried to prescribe me psych meds. Then just before I become bedridden many of my joints started developing cyst around them including my fingers and toes. The pain was beyond anything I could describe. I finally found a doctor who know immediately what it was but said I was so ill that giving me antibiotics my kill me. I thought she forgot about me because I laid for four months. My Facebook friends were teaching me how to heal and I was slowly getting better. Then my new doctor called said she finally found someone who knew how to treat someone who was as ill as I was.

It took me so long to get treated that it destroyed my health, I lost my job and you will be denied disability if you get Lyme. I have watched Lyme sufferers starve to death and become homeless because most peoples family will not research things but will believe the false narratives surrounding Lyme so they offer no help and actually do things to try and force use into doing things we are not capable of doing. I lost everything I had even my tools. To eat and to get medical treatment I had to sell everything I had. There are many Lyme suffers Laying bedridden right now with family that will not help them and treat them horrible because of the false narratives out there.

God does not accept ignorance as an excuse when the truth is easily available so all those involved, even those who choose to remain ignorant neglect those suffering will be held accountable on Jehovah’s great day.

I have covered why many die before getting diagnosed with Lyme in another blog post.

https://iamajuicer.wordpress.com/2018/12/15/why-most-die-before-getting-a-diagnosis-of-lyme-disease/

This is why there cannot be a real Lyme test.

https://badlymeattitude.com/2018/08/08/why-there-cant-be-a-real-lyme-test/

Ticks are not the only methods of Lyme transmission other biting insects can transmit it. It can be transmitted from mother to child, It can also be transmitted sexually. Many who have gotten Lyme do not remember getting bitten by a tick because most likely they were not bitten by a tick but became infected through other means.

https://iamajuicer.wordpress.com/2018/07/21/things-they-would-rather-you-did-not-know-about-lyme/

https://iamajuicer.wordpress.com/2018/06/20/why-many-do-not-know-how-they-got-lyme/

God sees what they are doing and will hold them accountable.

Jeremiah 8:“How can you say, ‘We are wise, and the law of the Lord is with us’? But behold, the lying pen of the scribes has made it into a lie.
9 The wise men shall be put to shame;they shall be dismayed and taken; behold, they have rejected the word of the Lord,
so what wisdom is in them?
10 Therefore I will give their wives to others
and their fields to conquerors,because from the least to the greatest everyone is greedy for unjust gain; from prophet to priest,everyone deals falsely.
11 They have healed the wound of my people lightly,
saying, ‘Peace, peace,’when there is no peace.
12 Were they ashamed when they committed abomination?
No, they were not at all ashamed;they did not know how to blush.
Therefore they shall fall among the fallen;
when I punish them, they shall be overthrown,says the Lord.

2Peter 2:7 and if He delivered righteous Lot, vexed with the filthy conduct of the wicked

8 (for that righteous man, having dwelt among them seeing and hearing, was vexed in his righteous soul day after day with their unlawful deeds)—

9 then the Lord knoweth how to deliver the godly out of temptations and to reserve the unjust unto the Day of Judgment to be punished,

10 but chiefly those who walk after the flesh in the lust of uncleanness, and despise governance. Presumptuous are they and selfwilled; they are not afraid to speak evil of dignities,

11 whereas angels, which are greater in power and might, bring not railing accusation against them before the Lord.

12 But these, as natural brute beasts, made to be taken and destroyed, speak evil of the things that they understand not, and shall utterly perish in their own corruption,

13 and shall receive the reward of unrighteousness, as those who count it pleasure to revel in the daytime. Spots they are and blemishes, sporting themselves with their own deceptions while they feast with you,

14 having eyes full of adultery and who cannot cease from sin, beguiling unstable souls; their hearts they have exercised with covetous practices; accursed children!

15 They have forsaken the right way and have gone astray, following the way of Balaam the son of Beor, who loved the wages ofunrighteousness,

16 but was rebuked for his iniquity: the dumb ass speaking with a man’s voice forbad the madness of the prophet.

17 These are wells without water, clouds that are carried by a tempest, for whom the mist of darkness is reserved for ever.

18 For when they speak great swelling words of vanity, they allure through the lusts of the flesh and through much wantonness those who had clean escaped from those who live in error.

19 While they promise them liberty, they themselves are the servants of corruption; for by whom a man is overcome, by the same is he brought into bondage.

Proverbs 21:He who shuts his ear to the cry of the poor Will also cry himself and not be answered.

Micah 3:4 Then they will cry out to the LORD, But He will not answer them Instead, He will hide His face from them at that time Because they have practiced evil deeds.

(Psalm 12:5)  5 “Because the afflicted are oppressed, Because of the sighing of the poor, I will rise up to act,” says Jehovah. “I will save them from those who treat them with contempt. . .

(Proverbs 28:24-27) 24 Whoever robs his father and mother and says, “It is not wrong,” Is a partner of the man who causes ruin. 25 The greedy person stirs up dissension, But whoever relies on Jehovah will prosper. 26 Whoever trusts in his own heart is stupid, But the one who walks in wisdom will escape. 27 Whoever gives to the poor will lack nothing, But the one who closes his eyes to them will receive many curses.

Why many die before getting a diagnosis of Lyme disease.

 

Lyme disease destroys ones life. Because of the corruption and lies surrounding Lyme most do not get diagnosed until it is too late and their health has already been destroyed. They get no help from the government, medical community or family. I have seen many become homeless and die from being refused medical treatment and not having money to buy food.

https://peerj.com/articles/322/

There is a myth that a person will get a rash and this rarely occured in most I know who had gotten Lyme.

LYMEPOLICYWONK: How many of those with Lyme disease have the rash? Estimates range from 27-80%.

A myth that many governments around the world propagate is that a tick has to be attached for 24 hours for a person to become infected with Lyme. They can be infected immediately especially if they smash the tick while removing it because it can cause some of the fluids from the tick to enter the bite area. The quicker a tick is safely removed the less chance a person has of getting Lyme but the 24 hour time period is a myth. There is evidence showing Lyme disease can be rapidly transmitted. The worst part of it is There are many types of bacteria that cause Lyme but the test only test for a few of them. The test has a very high failure rate and because of the nature of borrelia and it’s ability to morph in order to evade detection by the immune system and to protect itself from the body the longer it goes without being treated the more likely a person is to develop chronic Lyme.

http://campother.blogspot.com/2013/10/24-hours-of-attachment-is-estimate-not.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278789/

http://www.ncbi.nlm.nih.gov/pubmed/22104184

http://lymedisease.org/news/hardscienceonlyme/hard-science-on-lyme-ticks-can-transmit-infection-the-first- day.html

Controversies and Challenges

Study finds nymphal ticks can transmit Lyme within 12 hours

Why the Lyme test fails.

Why There Can’t be a Real Lyme Test

Lyme destroys the heart.

https://www.sciencedirect.com/science/article/pii/S1054880715000253

https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6249a1.htm?s_cid=mm6249a1_w

https://ajp.amjpathol.org/article/S0002-9440(16)00099-7/abstract

https://www.bayarealyme.org/blog/story/neil-spector/

https://www.lymedisease.org/touchedbylyme-deceased-lyme/

Some are having to sue.

https://www.dropbox.com/s/9qdt78jnq5i6lne/PA%20Lawsuit%20MS%20Misdiagnosis.pdf?dl=0

There is a lot of fraud and flaws with Lyme testing and it has been 30 years since the fraud was exposed and our government will do nothing about it. Lyme test do not work and the guidelines set out by the CDC and IDSA are based on fraudulent research. It is why people have to die first before they are properly diagnosed with Lyme. The test for Lyme was meant to be used to track Lyme disease cases it was not meant to be used for clinical diagnoses so why are they requiring it to be used before a person can be treated?

https://dariningelsnd.com/lyme-disease-testing-continues-fail-properly-identify-lyme-disease/

https://www.lymedisease.org/lyme-basics/lyme-disease/diagnosis/

They will probably never be able to create a test for Lyme because of the complexity of Lyme iteslf.

https://badlymeattitude.com/2018/08/08/why-there-cant-be-a-real-lyme-test/

https://rawlsmd.com/health-articles/testing-chronic-lyme-disease-really-worth

Though the test may offer some hope if they get diagnosed chances are if they have Lyme even the most reliable test can be negative but it increases your chances of being able to be treated if you get tested and it shows you have Lyme.

http://www.betterhealthguy.com/lyme/testing

http://lyme-basics.com/lyme-disease-basics/co-infection-bartonella/

There are many strains of Lyme but the test only test for two that I know of. So what happens of a person has one of the many other types of Lyme infections? It will go undetected.

https://www.tiredoflyme.com/4-reasons-a-lyme-test-will-come-back-negative-even-if-a-person-truly-has-lyme-disease.html

https://jamanetwork.com/journals/jamadermatology/fullarticle/478082

https://wwwnc.cdc.gov/eid/article/10/9/04-0236_article

Sadly they are still running on the Lyme testing hamster wheel and it is going no where and is why it should be a clinical diagnoses. Or they should have the blood put directly under the microscope to looke for live spirochetes. Sadly even that fails. I have seen people told they do not have Lyme after getting their blood put under a microscope when you could clearly see Lyme spirochetes in the persons blood. Why all the lying?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441761/

The true number of those dying from Lyme will never be known because unlike HIV, or other illnesses that they list on the death certificate complications of HIV or diabetes or things of that nature with Lyme they will list it as renal failure or heart failure. Also because Lyme damages the brain and causes depression suicide rates are very high with Lyme sufferers so there again though Lyme indirectly was the cause of death it is not what the death certificate would say.

https://owndoc.com/lyme/dying-of-lyme-disease-case-fatality-rate-nearly-100/

http://laedwardswriter.com/lyme-disease-news-lets-get-right

Here is a site with a lot of informative links. You have to copy and paste the links in to your address bar.

http://www.mohawkvalleylymesupportgroup.com/resourc/myth-vs-fact-lyme-disease

Autoimmunity what causes it and things that may correct it.

This is not medical advice, I am posting this for informational and educational purposes.

Mitochondria regulate our immune response and oxidative stress. Many things can cause mitochondria dysfunction. This can lead to metabolic issues, excess oxidative stress and autoimmunity which can lead to cancer and other chronic illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052888/

 

There are many symptoms of autoimmune disorder.

https://www.powerofpositivity.com/20-signs-may-autoimmune-disorder-reverse

OspA is a major cause of autoimmunity. It is why many with Lyme do not recover.

Why We Hate OspA: Shortest Explainer Ever

http://www.jimmunol.org/content/166/8/5286.long

I have seen many get diagnosed with pancreatic cancer to learn later they actually had an infection.

http://www.mdedge.new-evidence-of-synergy-between-vitamins-a-and-d-protection-against-autoimmune-diseases

TH17 imbalance is common in those with psoriasis and interstitial cystitis.

https://drknews.com/nitric-oxide-modulation-for-autoimmune-disease/#

When dealing with automine disorders there are naturals that help but can have side effects like inducing temporary menopause.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737660

Inflammation is one of the main contributors to atuimmune disorders. Little things help, such as standing on the ground in our bare feet.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378297

Anti phospholipid syndrome is an autoimmune disorder that is commonly results from vaccine injury.

http://www.scielo.br/scielo.php?pid=S0365-05962005000300002&script=sci_arttext&tlng=en

http://journals.sagepub.com/doi/full/10.1177/0961203312438115

Hapten response can cause autoimmune disorders. It can be caused by many things from vaccinations, Lyme disease and environmental toxins like glyphosate. Poison ivy causes a hapten response. The body starts attacking itself to try to rid itself of a problem it cannot identify. That is why many with tick born illness get a rash similar to poison ivy.

https://www.hindawi.com/journals/jir/2014/175265

One of the major causes of autoimmune disease is vaccinations. Sometimes the symptoms are so subtle that most do not realize they have an autoimmune disorder. Allergies are an autoimmune disorder.

https://vaccinechoicecanada.com/science-supporting-vaccine-risk/autoimmune-disease

Pyrrole disorder is common but gets over looked. It can be corrected with the proper nutrients. Omega 3s usually reduce inflammation. In those with pyrrole disorder Omega 6 can cause inflammation. They are needed so we cannot avoid them but should be careful how much we get until we address the problem.

https://www.samanthagilbert.com/pyroluria-pyrrole-disorder

https://growyouthful.com/ailment/pyroluria.php

https://mthfrsupport.com/2016/02/impacts-to-our-snps-via-foodtoxins-and-the-resulting-domino-effect-on-their-genetic-expression

Not sure if mad cow disease would be an autoimmune disorder but vaccinations can cause it.

http://www.vaccineriskawareness.com/Vaccines-BSE-and-vCJD

Vaccinations cause a B cell imbalance. This results in higher zonulin levels which causes leaky gut, interstitial cystitis, and even leaky brain.

https://www.sciencedaily.com/releases/2017/05/170510174845.htm

Vaccinations cause Mast Cell Activation Syndrome which can result in pulmonary disease.

http://jvi.asm.org/content/77/18/9831.full

Drugs are another thing that can cause autoimmune disorders especially statins.

https://www.ncbi.nlm.nih.gov/pubmed/17207162

Drugs cause Lupus which affect things at a chromosome level. This makes it very difficult to correct.

https://arthritis-research.biomedcentral.com/articles/10.1186/ar3281

If you must get vaccinations make sure your vitamin A and vitamin D levels are not low. This will reduce your risk of autoimmune disease.

https://www.westonaprice.org/new-evidence-of-synergy-between-vitamins-a-and-d-protection-against-autoimmune-diseases

Toxins like glyphosate and antibiotics is why autoimmune disease is so rampant now. Our gut bacteria modulate our immune system. Those destroy our gut bacteria.

http://www.sciencedirect.com/science/article/pii/S1074761312002373

Most now know vaccinations cause autoimmune disorders. The aluminum in vaccinations is very toxic.

https://www.ncbi.nlm.nih.gov/m/pubmedAutoimmune

https://www.ncbi.nlm.nih.gov/pubmed/20708902

Our food is toxic now days. Glyphosate and vaccinations have been found to cause leaky gut. Leaky gut can cause autoimmune disorders.

http://www.healingisfreedom.com/science/top-5-ai-triggers-part-5-leaky-gut-dysbiosis

http://neurosciencenews.com/autoimmune-disorders-microbiome-7789

Allergies are an autoimmune disease. Vaccinations are known to cause many types of allergies.

https://www.researchgate.net/publication/310021910_Significant_protein_sequence_alignment_between_peanut_allergen_epitopes_and_vaccine_antigens

http://www.discoverymedicine.com/Hedi-Orbach/2010/02/04/vaccines-and-autoimmune-diseases-of-the-adult

http://www.gulflink.osd.mil/medsearch/HealthResearchOfAlliedFo/DoD106.shtml

I would not have thought of narcolepsy as an autoimmune disorder. But We can add it to the list.

http://stm.sciencemag.org/content/7/294/294ra105

Hydrangea root helps with TH17 imbalance which is common in those with interstitial cystitis and psoriasis.

https://www.medicalnewstoday.com/articles/152822.php

Some herbs will make autoimmune disorders worse and some help.

https://www.cloverleaffarmblog.com/autoimmune-diseases-herbs-avoid-better-health/2015/02

TH17 imbalance is common in inflammatory bowel disease.

http://www.annualreviews.org/doi/abs/10.1146/annurev-pathol-011110-130318

Tick born illness can also cause a TH17 imbalance.

http://www.sciencedirect.com/science/article/pii/S0022202X15336733

Restoring Treg cell homeostasis helps correct autoimmune disorders.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276397

Cannabinoids can help reduce TH17 dominance.

https://www.ncbi.nlm.nih.gov/pubmed/23892791

Balancing TH1 and TH2.

http://thyroidnation.com/th1-th2-connection-immune-system

A good article on supplements that stimulate TH1 or TH2.

http://autoimmunewellness.com/how-do-you-balance-th1-and-th2-in-autoimmune-disease

A good article on TH1 and TH2.

http://autoimmunewellness.com/what-is-the-role-of-th1-and-th2-in-autoimmune-disease

Mineral deficiencies can cause a T cell imbalance.

https://www.ncbi.nlm.nih.gov/m/pubmed/10944485

The effect of high or low histamines.

 

This is not medical advice I am posting this for educational and informational reason only.

 

There are two sources of histamines endogenous and exogenous. Endogenous means from within or internally so is produced inside the body. Exogenous is introduced to or produced from outside the body. There are health issues with high or low histamines. Narcolepsy is in it’s own class it alternates between high and low histamine.

Histamine has many functions in the body , it is involved in the immune response, regulating physiological function in the gut. It acts as a neurotransmitter in the brain , spinal cord and uterus. It is involved in inflammation and the itching we feel. Histamine is produced by basophils and mast cells types of white blood cells. Histamines increases the permeability of blood vessels to allow white blood cells and some proteins to pass through so they can to engage pathogens in infected tissues.

Histamines generated in granules in mast cells and basophils. Most cells are more numerous in sites of the body that is more prone to injury like the mouth , nose, internal body surfaces and blood vessels. Non mast cell histamine in found in areas such as the brain. Another site of histamine storage and release is in enterochomaffin-like cell (ecl). This is an area in the gastric mucosa. Because of histamines properties it is versatile and able to interact and bind more easily.

The most important role of histamine is immunologic. When the mast cells or basophils have been sensitized to a pathogen by IgE antibodies that attach to their membranes will degranulate when exposed to the appropriate antigen. Certain amines, alkaloids found in plants can displace histamine in granules and cause their release. The break down of amino acids releases amines which are higher in aged meats. Lowering IgE can reduce histamine release.

Histamine is involved in anaphylaxis. Anaphylas is a rapid onset allergic reaction. It can involve itchy rashes, throat and tongue swelling, shortness of breath, lightheadedness, vomiting and low blood pressure. Sometimes they develop over hours. Vaccinations and toxins in our environment and food are known causes of a person developing allergies.

Histamine gated chloride channel is said to be expressed in the hypothalamus, thalamus, and intestines. It has synaptic inhibitory effects. It inhibits the GABA receptors making us more awake. It is also involved in diarrhea.

Histamines are the cause of runny noses. Increased vascular permeability caused by histamines causes fluid to leak from the capillaries into the tissue which leads to runny nose and watery eyes. Allergens can bind to IgE-loaded mast cells in the mucous membrane. This is what causes the sneezing, hyper secretion from glandular tissue, and congested nose from the vasodilation increasing the size of the blood vessels.

Histamine is a neural transmitter that is released from histamine neurons in the hypothalamus (hypothalamus links the nervous system to the endocrine system via the pituitary gland.) . These cells are located in a part of the hypothalamus known as tuberomammilian nucleus. The tuberomammilian nucleus consist largely of histamine neurons and is involved in sexual arousal, learning, memory, sleep and energy balance. The nuerons in this area comprise the brain’s histamine system. It contains nerve fibers that connect it to other areas of the brain.

Enterochromaffin-like cells located within the gastic glands of the stomach that stimulates a certain type of epithelials cell by binding to the end of the H2 receptor. Stimulation of the pariental cells (stomach epithelial cells that secret hydrochloric acid) induces the uptake of carbon dioxide and water from the blood, which is then converted to carbonic acid by the enzyme carbonic anhydrase. Inside the cytoplasm of the pariental cell the carbonic acid readily disassociates into hydrogen and bicarbonate ions. The bicarbonate ions diffuse back through the basilar membrane and into the blood stream while the hydrogen ions are pumped into the lumen of the stomach via specialized pumps. Histamine release is halted when the ph of the stomach starts to decrease. Certain drugs contain antagonist molecules that block the H2 receptor and prevent histamine from binding causing decreased hydrogen ion secretion. Antagonist is a type of receptor ligand that blocks or dampens biological response by binding to and blocking a receptor.

Though histamines have stimulatory effects on neurons it also has suppressive effects against the susceptibility to convulsions, and lesions in the brain.

Those with schizophrenia have increased histamine metabolites in their cerebrospinal fluid and the efficiency of the H1 receptor binding sites is decreased. This can be caused by the toxins in vaccinations, farm chemicals found in our food, heavy metals or inflammation.

Seeing all that histamines do demonstrates the importance of histamine homeostasis. To much can cause many health problems and if inhibited it can cause many health problems. Now knowing the types of histamine receptors will help identify where a specific problem may be. This helps identify the most probably cause of the health problems. For example vaccinations damage certain areas in the brain that that could effect the histamine receptors in our brain that effect our sleep and wake cycle. BT Toxins and the farm chemicals used on them cause leaky gut which can effect histamines throughout the body. Identifying the areas effected by histamines helps narrow the cause down. If you read studies on those who take frequent antihistamines they eventually develop autoimmune disorders which shows the importance of achieving homeostasis so once you have reach homeostasis you should work on maintaining it. Many over do things by continuing the same protocols even those the problem has been corrected which ends up creating other problems.

There are four types of histamine receptors H1-H4.

H1 is expressed in the central nervous system (brain and spinal cord). It is involved in the sleep wake cycle. It promotes wakefulness. It is involved in body temperature regulation, hormone regulation, it can simulate appetite, it constricts the airways, it can increase the sensation of pain, especially in the pelvis and stomach. It can also cause uticaria and itch perception.

H2 is expressed in the central nervous system, stomach, mast cells, vascular smooth muscle cells, cells in the heart and uterus. It has very few effects on the brain, most H2 receptor ligands cannot cross the blood brain barrier. Primarily involved in vasodilation and stimulation of gastric acid and appetite.

H3 Located primarily on basophils in the bone marrow, thymus, spleen and intestines. Plays a role in mast cell chemotaxis (movement cells in response to a chemical stimulant), sensation of itching, cytokine production and secretion, heightened pain in inner organs, involved in inflammation and allergies.

Some H1 agonist can cause drowsiness while H3 agonist can cause wakefulness.

In some illnesses T Cells attack the bodies own cells. H1 and H4 make the symptoms worse will H2 and H3 decrease the symptoms. They believe it is because H2 and H3 help with T Cell differentiation in the immune system. So this would help differentiate between our own cells and a pathogens, preventing the immune system from attacking it’s own cells.

Since histamine are an important part of the immunes system disorders involving histamines can have effects on our immune system. Things like mastocytosis and mast cell activation syndrome. They have some differences but the remedies for them are pretty much the same so I will probably just say mast cell disorders. They are caused by excess mast cell degranulation. Many of these illnesses they claim are genetic but they are finding it is the gut bacteria that modulate those genes that are inherited or that a person may be lacking. Also gene mutations usually do not present themselves unless many other things have went wrong. To reach homeostasis you have to address any other health issues especially leaky gut. When you have high histamines and your nose runs it will be clear or white colored. When it is from and infection it will be different it will be darker colored, I have seen green, brown when the infection is in the tissues, I have even seen yellow.

https://www.healthcoach7.com/2015/04/16/mast-cells-histamine-friend-or-foe/

https://www.nature.com/articles/s41598-017-16019-8

Anaphylaxis is caused by mast cell degranulating.

Histaminosis is a disorder that is caused by a shortage of the enzymes that break down histamine. Diamine Oxidase and Histamine N-methyltransferase.

Diamine Oxidase (DAO) known as histiminase is an enzyme involved in the metabolism, oxidation and inactivation of histamine and other polyamines. Poly amines are found in aged meats and fermented foods. The highest levels of DAO are found in the digestive tract and placenta.

Histamine N-methyltransferase also reduces histamines. The Cytochrome P450 enzymes are involved. Glyphosate inhibits CytP450 Ezymes which raises histamine levels. This is also why it is very important to address inflammation because that can inhibit detoxing.

http://alisonvickery.com.au/what-if-this-was-about-the-liver/

https://www.marioninstitute.org/histamine-intolerance-syndrome/

A deficiency in these enzymes can lead to asthma.

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2222.2007.02769.x

Our gut bacteria can add to the histamines causing asthma , we need to increase our histamine digesting microbiome.

https://www.jacionline.org/article/S0091-6749(16)30709-6/abstract

When levels are low it effects our sleep and we become aggressive.

https://www.nature.com/articles/s41598-017-16019-8

Also our gut bacteria reduce histamines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709439/

https://kresserinstitute.com/gut-flora-food-allergies-connection/

https://wholenewmom.com/health-concerns/low-histamine-probiotics/

https://factvsfitness.com/probiotics-histamine-intolerance/

We must heal our guts

https://bodyecology.com/articles/histamine-hack-how-to-safely-eat-fermented-foods

https://blog.bulletproof.com/how-to-own-your-gut-bacteria-and-fix-leaky-gut-syndrome/

The above mentioned conditions can be set off by toxins like heavy metals and farm chemicals which are found in our food especially glyphosate. It can be set off by pathogens especially Lyme disease. Excess inflammation can increase the risk of these happening along with oxidative stress.

https://www.selfhacked.com/blog/histamine/

DAO deficiencies and high histamines.

http://www.deficitdao.org/en/dao-deficiency/what-is/#.Vtdu0urUV6c.facebook

Symptoms of mastocytosis are anaphylaxis, low blood pressure, hives and swelling, itching, nausea or vomiting, diarrhea, fainting, headache, uterine cramps, bleeding, flushing, and muscoskeletal pain.

https://www.aaaai.org/conditions-and-treatments/related-conditions/systemic-mastocytosis

https://www.mayoclinic.org/diseases-conditions/systemic-mastocytosis/symptoms-causes/syc-20352859

https://arupconsult.com/content/mast-cell-disorders

https://my.clevelandclinic.org/health/articles/5908-mastocytosis

http://mastocytosisawareness.blogspot.com/p/up.html

Pediatric mastocytosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869446/

Test for mastocytosis.

https://tmsforacure.org/tests/

Symptoms of Mast Cell Activation Syndrome are flushing, hives and swelling, nasal itching and congestion, wheezing and shortness of breath, throat itching and swelling, headache, brain fog, cognitive dysfunction, mental issues like anxiety or depression, diarrhea, abdominal pain, bloating, GERD, bone and muscle pain, lightheadedness, rapid heart rate, low blood pressure, uterine cramps or bleeding.

https://tmsforacure.org/symptoms/symptoms-and-triggers-of-mast-cell-activation/

https://www.healthline.com/health/mast-cell-activation-syndrome#causes

https://www.sott.net/article/332968-Could-mast-cell-activation-disorder-be-the-root-cause-of-your-histamine-intolerance

https://link.springer.com/article/10.1007%2Fs11882-012-0322-z

POTS caused by myocarditits can be caused by mast cell activation.

http://www.dysautonomiainternational.org/blog/wordpress/a-tale-of-two-syndromes-pots-and-mcas/

http://hyper.ahajournals.org/content/45/3/385

Symptoms histaminosis most commonly known as histamine intolerance can manifest as intolerance to sulfur, food sensitivities especially gluten, gliaden, and milk products., sensitivity to amines found in aged meats and fermented foods. Gastrointestinal issue, excessive gas, diarrhea, cramps, fatigue, insomnia, noise sensitivity, hives, hypertension, and depression.

https://www.dietvsdisease.org/histamine-intolerance/

http://davidjernigan.blogspot.com/2015/07/histamine-intolerance-not-allergies-may.html

https://www.mindbodygreen.com/0-11175/everything-you-need-to-know-about-histamine-intolerance.html

https://www.marioninstitute.org/histamine-intolerance-syndrome/

https://itchylittleworld.com/are-you-suffering-from-histamine-intolerance/

https://www.marksdailyapple.com/histamine-intolerance/

Diagnosing Guidlines.

https://www.croh-online.com/article/S1040-8428(14)00149-8/fulltext

Fluroquinolone causes mast cell activation.

Can Fluoroquinolones Activate Mast Cells?

The whole body is effected by mast cell activation.

https://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-4-10

High estrogen and low progesterone can cause high histamines. Many toxins like glyphosate and BPA can cause this.

https://www.larabriden.com/the-curious-link-between-estrogen-and-histamine-intolerance/

When you have problems with histamines it is very important to adjust your diet to reduce histamines and amines. Once you reach homeostasis you can slowly reintroduce them back into your diet. Because most of the solutions for addressing the various disorders overlap I won’t mention which disorder it helps because for the most part all will be helped by the things mentioned. Do your research to be better able to develop a protocol unique for you. We are all different and can not do a one size fits all protocol. Most of these symptoms can be caused by gut bacteria imbalance or leaky gut.

https://healinghistamine.com/leaky-gut-the-mast-cell-histamine-crohns-disease-connection/

https://blog.bulletproof.com/why-yogurt-and-probiotics-make-you-fat-and-foggy/

http://alisonvickery.com.au/anti-histamine-foods/

http://www.mastcellmaster.com/publications.php

Lectins, leaky gut and histamines.

http://www.histamine-intolerance.info/low-histamine-diet/#undefined.gbpl

Specific diets like the paleo diet should only be used until the problem has been corrected.

http://alisonvickery.com.au/why-olive-oil-and-a-paleo-diet-increases-dao/

https://www.selfhacked.com/blog/deal-histamine/

https://healinghistamine.com/reacting-to-everything-this-could-be-why/

Melatonin reduces histamines.

https://healinghistamine.com/melatonin-mast-cells-and-histamine/

Vaccinations cause allergies and getting the measles protects against allergies.

http://pediatrics.aappublications.org/content/123/3/771?sso=1&sso_redirect_count=1&nfstatus=401&nftoken=00000000-0000-0000-0000-000000000000&nfstatusdescription=ERROR%3a+No+local+token

https://www.ncbi.nlm.nih.gov/pubmed/10714532

https://www.karger.com/Article/Abstract/254898

https://www.karger.com/Article/Abstract/24196

https://www.medical-hypotheses.com/article/S0306-9877(04)00044-1/fulltext

Genetically modified foods increase amines similar to those caused by food poisoning. This would cause gut issues and a rise in histamines.

https://www.ncbi.nlm.nih.gov/pubmed/27991589

Luteolin prevents mast cell degranulation.

https://www.naturalhealthnews.uk/herbal-remedies/2015/01/black-ginger-extract-could-help-control-psoriasis-flares/

https://www.jacionline.org/article/S0091-6749(14)01574-7/abstract

Tick born illness can induce mast cell activation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC96436/

Caffeic Acid reduces histamines. Caffeic acid is high in beer, whole wheat, rye, plums, dates, berries, peaches, apples, olive oil, sage, thyme, oregano,nut , vinegar and corn. They must be organic because the BT Toxin in GMOs will make the body produce histamines.

https://www.sciencedirect.com/science/article/pii/S0014299915300716?via%3Dihub

https://www.medicalnewstoday.com/articles/319510.php

I find it interesting that GMOs kill the gut bacteria that help with Serotonin production and many with mastocytosis have low serotonin levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795418/

This is MTHFR and histamines. Genes that cause issues usually don’t present unless there are other health problems. Addressing them will usually correct the problems then take action to support the offending genes. If you read my post on “It is not your genes it is your gut microbiome” you will see many things that are supposedly gene mutation are actually a lack of gut bacteria that modulate those genes.

https://www.drbenlynch.com/resource/dr-lynch-interview-mthfr-overmethylation-histamine-asthma/

https://www.samanthagilbert.com/histamine-mast-cell-disorder-or-methylation-imbalance/

https://www.mthfrsupport.com.au/hnmt-cofactors-and-inhibitors/

http://alisonvickery.com.au/a-list-of-bio-individual-histamine-inhibitors/

https://metabolichealing.com/lifting-methylation-cycle-blocks-using-individual-nutrient-therapies/

https://www.geneticlifehacks.com/notes-about-histamine-and-mast-cells/

http://mthfrliving.com/health-conditions/mast-cell-activation-disorder-histamine-intolerance/

Histamine degrading enzymes and their cofactors.

https://www.mthfrsupport.com.au/histadelia-vs-histapenia/

Histone inhibitors may stop gene expression that may be causing mast cell activation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210916/

Falcarinol a cannabioid found in carrots, celery and other plants that are related reduces allergies.

http://geneticgenie.org/blog/2013/01/31/mast-cell-activation-disorder-mcad-chronic-illness-and-its-role-in-methylation/

https://www.ncbi.nlm.nih.gov/pubmed/20206138

Strategies to reduce run away mast cells.

http://goodbyelyme.com/stopping_mast_cell_inflammation

https://www.prohealth.com/library/study-shows-that-mast-cell-activation-a-disorder-common-in-lyme-disease-causes-depression-5478

Quercetin reduces mast cell activation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576204/

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033805

Because our food has been found to contain glyphosate we should avoid GMO and foods that contain it. Try our best to eat organic.

https://www.researchgate.net/publication/305318376_Glyphosate_pathways_to_modern_diseases_V_Amino_acid_analogue_of_glycine_in_diverse_proteins

When H Pylori is commensal it protects us from allergies.

https://m.jci.org/articles/view/45041

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548235/

Rehmannia reduces mast cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331951/

If we do not address histamines and inflammation it can lead to autism.

https://karmayogadaily.com/2017/04/15/groundbreaking-research-autism-histamine-inflammation-mast-cell-activation/

https://sites.google.com/site/fansofdrtheo/finding-dr-theo

When we have an infection histamine levels go up so getting the pathogen load down is very important.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938197/

High homocysteine can increase inflammation which can raise histamines.

https://www.nature.com/articles/ajg2005155

Raised histamines leads to arthritis.

http://www.jimmunol.org/content/174/12/7665.long

Raised histamines can cause adrenal fatigue.

https://www.drlam.com/blog/histamine-levels/5906/

purslane reduces histamines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316266/

Things that increase DAO to decrease histamines. Some are high sulfur foods and if you have high sulfite levels , CBS, or BH4 and have not addressed it you will make yourself worse.

https://healinghistamine.com/how-to-naturally-boost-production-of-the-histamine-degrading-dao-enzyme/

Naturals for reducing histamines.

https://www.healthline.com/health/allergies/best-natural-antihistamines#3

https://www.secondopinionphysician.com/treat-elevated-histamine/

Food additives increase inflammation and histamines.

https://www.peertechz.com/articles/immunomodulatory-effects-of-food-additives.pdf

High histamines contribute to Chronic Fatigue and fibromyalgia

https://www.ncbi.nlm.nih.gov/pubmed/29223146

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767394/

Vaccinations and GMOs cause leaky gut which causes high histamines.

https://healinghistamine.com/leaky-gut-the-mast-cell-histamine-crohns-disease-connection/

We cannot reduce oxalate entirely but would should reduce them. Most oxalates are formed inside the body so it is best to correct the problem causing them. Also leaky gut will leave oxalates enter the body.

https://healinghistamine.com/low-oxalate-low-histamine-diet-the-missing-link/

Reducing mast cells helps with diabetes and obesity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318912/

There is a lung list of illnesses caused by mast cell activation from fibromyalgia to interstitial cystitis. Mast cells release trypase and it has been found to be high in interstitial cystitis indicating that mast cell activation is and issue in interstitial cystitis.

http://www.mastcellaware.com/mast-cells/related-conditions.html

http://erj.ersjournals.com/content/29/5/861

https://www.jurology.com/article/S0022-5347(01)61915-3/fulltext

Those with mast cell activation do not always develop skin problems which is often used to diagnose it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715414/

https://tmsforacure.org/tests/

Drugs for mast cell activation. Drugs treat the symptoms so I would work on the cause while you hold the symptoms at bay.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903110/

Mast Cell Activation increases our risk of cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710302/

High IgE levels and high mast cell activation do not always coincide with each other.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782795/

I put three drops of tea tree oil in 8 ounces of jojoba oil it helped me skin inflammation and rashes a lot.

https://www.ncbi.nlm.nih.gov/pubmed/?term=12452873

Hydroxyurea helps with mast cell activation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851743/

Food sensitivities and mast cells.

https://naturalnutmeg.com/when-food-sensitivities-take-over-the-mast-cell-connection/

Mast cells can protect the nerves or damage them. That is why homeostasis is important.

https://aacijournal.biomedcentral.com/articles/10.1186/1710-1492-1-2-65

Vitamin E which is high in olive oil and fish oil stabilizes mast cells.

https://www.wellnessresources.com/news/tocotrienols-stabilize-mast-cells

Vitamin D3 helps reduce mast cell activation but in doses higher then 4000 IU it can cause oxalates to form. That is why life guards have the highest incidence of kidney stones because our bodies make vitamin D when sun light hits our skin.

http://www.sciencedomain.org/abstract/687

Honeysuckle has many benefits including reducing allergies.

https://www.hindawi.com/journals/ecam/2015/905063/

Mast cell activation can cause high IL 17 levels which can cause Lupus and COPD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353957/

Mast cells can be an indicator of toxins.

http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-37092015000100006

Mercury and mast cells cause brain deterioration.

https://link.springer.com/article/10.1007/s11064-015-1790-z

A disruption in the endocanabinoid system can cause allergies. But there is a big scam people believe that cannibus is the only source of cannabinoids and that is not true many plants have them and each has it’s own unique benefits. Big corporations own the cannabinoid crops though so you will not hear about the other cannabinoids that often times have more healing benefits.

https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(09)00107-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0165614709001072%3Fshowall%3Dtrue

Histamine Deficiency

We have to cover both side of the coin. Histamine deficiency can also cause health problems. It is why once we achieve homeostasis we should work towards maintaining it and not continue with the protocols that may inhibit it. We could cause other health problems by pushing things in the opposite direction.

This site give the symptoms of histapenia, it mentions to take folic acid. Do not take it, it is man made and damages the body. Folate is natural and does not harm the body, I do not know why but many medical professionals do not know the difference between folate and folic acid.

Any ways the symptoms of low histamine levels are inhibited immune system, elevated serotonin, elevated dopamine, elevated norepinehrine, and low histamine. Low basophil levels, food senstivities which is not the same as food allergies, difficulty digesting food, anxiety, low libido, becoming obssesed with things, paranoia, auditory hallucination, hyperactivity, delusions of grandeur, excessive sleepiness. It can be caused by overmethylation. With low histamines the nose can be dry and you may get nose bleeds.

http://www.digitalnaturopath.com/cond/C376401.html

https://custommedicine.com.au/health-articles/histapenia-over-methylation/

http://info.healthrecovery.com/hrc-blog/a-closer-look-at-a-low-histamine-histapenia-biochemistry

https://www.everywomanover29.com/blog/methylation-and-anxiety-histadelia-and-histapenia/

https://www.aafp.org/afp/2009/0301/p391.html

Histamines help prevent cancer, inhibiting histamines can make us more prone to cancer.

https://www.nature.com/articles/nm.2278

https://www.nature.com/articles/cddis2015378

https://www.tandfonline.com/doi/full/10.1080/2162402X.2015.1047581

Autophagy is how the body recycles chromosomes. When we are deficient in histamine it can damage the heart by inhibiting autophagy.

https://www.nature.com/articles/s41419-018-0723-6

https://www.ncbi.nlm.nih.gov/pubmed/26278136

H2 inhibitors cause vitamin B12 deficiency.

https://jamanetwork.com/journals/jama/fullarticle/1788456

This is an article on decreasing histamines but talks about things that raise histamines so could be used to figure out how to raise histamine levels.

https://www.secondopinionphysician.com/treat-elevated-histamine/

https://blog.bulletproof.com/why-yogurt-and-probiotics-make-you-fat-and-foggy/

http://healthyeating.sfgate.com/foods-histamines-tyramines-1208.html

Narcolepsy

Narcolepsy is in it’s own class it alternates between high and low histamine. Narcolepsy has low orexin levels which cause this.

https://healinghistamine.com/histamine-wakefulness-sleep/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1279673/

https://www.jci.org/articles/view/71017

Increasing orexin helps with narcolepsy.

https://www.selfhacked.com/blog/how-to-increase-orexin-and-decrease-fatigue-naturally/

https://www.narcolepsysupport.org/forums/topic/how-to-increase-orexin/

https://www.wikihow.com/Increase-Orexin

High sulfite levels can cause mast cell degranulation which results in high histamines. Gut dysbiosis, candida, endotoxins, mercury, glyphosate or anything else that inhibits sulfation can cause high sulfite levels.

https://www.annallergy.org/article/S1081-1206(10)63549-1/pdf

You can see histamines could be a sign of autoimmune disorder. These link explains some basics on histamines.

https://healinghistamine.com/reacting-to-everything-this-could-be-why

https://articles.mercola.com/sites/articles/archive/2017/01/25/is-histamine-to-blame-for-headache-hives-heartburn.aspx

Autism shows the same markers as an autoimmune disorder. Vaccinations cause autoimmune disorders and many people are compensated for it from the vaccine injury compensation fund.

https://openheartedrebel.com/2017/04/15/groundbreaking-research-autism-histamine-inflammation-mast-cell-activation

Tick born illness, fungul infections and mycoplasma which most vaccinations have been found to be contaminated with can cause high histamines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938197

Metabolic issues can cause induce asthma by raising histamines.

https://seekinghealth.org/resource/exercise-induced-asthtm

Porphyria is the illness, pyrroluria and kryptopyrolluria are symptoms of the illness.

This is not medical advice and should not be taken as such. I am posting this for informational and educational purposes.

Porphyria

If you have problems with consuming fats, like gall bladder pain, indigestion or feeling ill after eating them you most likely have Porphyria. You may be told you have Pyrolluria but it is a symptom of Porphyria. Meat and foods high in phenylalanine will increase porphyrins and ammonia levels in the body which will lead to Candida and H Pylori going from commensal to pathogenic. When it becomes more advanced the porphyrins will come out of the eyes and nose and are very caustic and will burn your skin. If you urinate and defecate them out the urinary tract and bladder will become irritated and when you defecate it will burn. 

Many know this as Pyrolluria or Kryptopyrolluria. You do not see updated research on those disorders because they discovered the high pyrroles was caused by a deficiency in various enzymes needed to break down uric acid. It causes high porphyrin levels. If you have Pyrroluria then look at the links and you will see the symptoms are the same. Pyrolluria is a symptom but not the problem. There are many things that can cause Porphyria , infection, drugs, chemicals, excess iron, stress, and to much sun. Fasting too much can also cause it. This can cause high ammonia levels because phenylalanine cannot be recycled.

https://www.medicinenet.com/porphyria/article.htm#what_causes_porphyria

https://www.mayoclinic.org/diseases-conditions/porphyria/symptoms-causes/syc-20356066

Infection

http://msphere.asm.org/content/1/1/e00023-15

http://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-39-4-262;jsessionid=Nxep_9-RQ5BILTpRdyrNY-OW.x-sgm-live-02

http://europepmc.org/abstract/med/2564227

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647859/

Clinical management.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562648/

https://draxe.com/porphyria/

I had this coming out of my eyes, nose and I was urinating it. I never got diagnosed but I thought it was blood. I now think it was my body detoxing.

http://www.porphyriafoundation.com/testing-and-treatment/testing-for-porphyria/tests-for-porphyria-diagnosis

https://neuromuscular.wustl.edu/nother/porph.htm

http://www.townsendletter.com/July2017/krypto0717_2.html

Baking soda normalizes bladder ph and reduces uric acid levels.

https://www.ncbi.nlm.nih.gov/pubmed/29498467