Detoxing we need it now days.

 

This is not medical advice I am posting this for information and educational purposes.

 

stock-photo-word-detox-is-made-from-chia-seeds-green-smoothies-and-ingredients-concept-of-diet-cleansing-the-646105657.jpg

There are so many toxins in our environment, our food, even in the our furniture that can cause a variety of health issues from hormone imbalance to autoimmune disorders. Now consider the toxins allopathic medicine is putting in us especially from vaccinations. Many of our bodies have been pushed to the tipping point. This can cause negative epigentic changes that can get passed down to children.

If you have acidosis or alkalosis then you must address the health problems causing them or you will be fighting a battle that is like running on a hamster wheel. I have posted on those.

It is very important to make sure phase 2 detox is working first. If you stimulate phase 1 and phase 2 is blocked it is like adding water to a dam that is already filled to capacity. The toxins will divert from the phase 2 detox pathway into the bloodstream. So detox should go Phase 2. Phase 1, then phase three autophagy as the final step.

https://jonbarron.org/detox/barron-report-kidney-blood-cleansing-4#.WKPPAjyX9s4.facebook

How the detox system works.

https://www.greatplainslaboratory.com/gpl-blog-source/2016/6/6/your-bodys-detoxification-pathways

http://www.gilbertssyndrome.com/detoxification.php

Our detox system protects us from cancer.

https://www.nature.com/articles/1209377

If phase 3 detox is blocked it causes Phase 2 to be down regulated.

https://www.fxmedicine.com.au/blog-post/what-phase-iii-detoxification

Various detox pathways and how they work.

http://www.lifeextension.com/protocols/metabolic-health/metabolic-detoxification/Page-01

Autophagy is the detox system at a cellular level. We must make sure phase 1 and 2 detox are working before we stimulate autophagy. You do not want to overstimulate it. Homeostasis is the goal.

https://blog.bulletproof.com/autophagy-for-longevity-detoxification/

Renal function can be restored no matter how severe.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081835#s4

This is a pretty good protocol to reduce vaccine injury. All vaccines injure, so if you are vaccinated you are vaccine injured and it is being blamed on genetics.

https://rense.com/general87/vaccin.htm

https://www.livingwhole.org/a-gentle-vaccine-detox-for-children/

A blog dedicated to detoxing children from modern day toxins.

https://recoveringkids.com/

Many are deficient in magnesium. I remember a doctor telling me it was toxic because it is a form of aluminum. I believed it at the time I was pretty young. I now know better. But I still hear this myth being passed around. It may be why magnesium deficiency is so high now. We cannot detox or heal without it and the body requires quite a bit. It is very hard to overdose on magnesium.

https://drcarolyndean.com/2012/12/magnesium-baths/

Metallothonein helps protect us from cancer by reducing oxidative stress caused by toxins. It also helps remove heavy metals from the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634463/

http://www.cease-therapy.com/treatment/metallothionein

https://www.sciencedirect.com/science/article/pii/S0041008X05800171

https://biofoundations.org/inducing-metallothionein-for-heavy-metal-detoxification-and-reducing-oxidative-stress/

 

We need to work hard now days to avoid toxins.

https://www.cleveland.com/lyndhurst-south-euclid/index.ssf/2017/01/make_2017_the_year_to_avoid_to.html

Phthalate can change a childs sexual preference.

http://www.sailhome.org/Concerns/BodyBurden/Burdens/Phthalate.html

https://www.naturalnews.com/027514_phthalates_feminization.html

https://toxtown.nlm.nih.gov/text_version/chemicals.php?id=24

https://draxe.com/phthalates/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928220/

Pesticides in non organic foods have been found to be high. This effects a childs health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914412/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428475/

Toxins that effect the thyroid.

https://www.mindbodygreen.com/0-12346/11-everyday-toxins-that-are-harming-your-thyroid.html

Toxins that disrupt hormones.

https://www.ewg.org/research/dirty-dozen-list-endocrine-disruptors?gclid=EAIaIQobChMI0dzCzMOP2QIV2A-BCh1eawecEAAYASAAEgKmmPD_BwE#.W0mU_teYXMq

Sunscreen can effect our hormones.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240241/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615097/

Glucuronidation helps balance our hormones, it also is needed to detox the toxins produced by mold and fungal infections. If it is inhibited we lose our resistance to mold and it will make us ill. Many chemicals in our environment inhibit it and it is why so many have mold illness now. This is good information on how to increase glucuronidation.

https://www.selfhacked.com/blog/glucuronidation-detox-estrogen-hormone-balance-prevent-cancer-red-meat/

Cholesterols function in bile secretion. Issues with the liver X receptor can cause issues with cholesterol metabolism.

http://www.jbc.org/content/278/18/15565.long

https://www.ncbi.nlm.nih.gov/pubmed/29523554

Olive Oil help resolve liver X receptor issues. But inhibits glucuronidation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521785/

Butyrate found in butter and ghee also help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111843/

High estrogen inhibits sulfation. Increasing UDP-glucuronosyltransferases will reduce estrogen levels.

http://www.jbc.org/content/275/46/36164.full.pdf

http://dmd.aspetjournals.org/content/30/5/564

DHA, oleic acid, and linoleic acid inhibit those enzymes.

https://www.nature.com/articles/srep02903

Sunscreen can cause endometriosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352028/

Sunscreen have a negative impact on babies in the womb.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820990/

Ways to possibly straighten hormones out.

https://detoxproject.org/glyphosate/hormone-hacking/

Chemical exposures early in life set us up for illness later in life.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370400/

https://www.ncbi.nlm.nih.gov/pubmed/26339156

http://www.chemtrust.org/brain/

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(13)70278-3/abstract

Toxins in vaccines are setting our children up for lower brain function. No wonder the US is falling behind other nations in education. They claim they do not use mercury in vaccine but that is not true some still contain mercury.

https://link.springer.com/article/10.1007%2Fs12311-011-0319-5

https://www.researchgate.net/publication/7503719_Mercury_and_Autism_Accelerating_Evidence

https://www.youtube.com/watch?v=GQYISvsgq6s

Selenium helps to reduce mercury toxicity.

https://www.tandfonline.com/doi/abs/10.1080/15563650.2017.1400555?journalCode=ictx20

Metallothionein is very important for detoxing by helping support the metabolic pathways.

https://metabolichealing.com/metallothionein-forgotten-antioxidant-missing-puzzle-piece-for-alzheimers-leaky-gut/

Bioflavonoids in the white part of citrus fruit helps with the metabolic issues caused by toxins.

https://academic.oup.com/advances/article/5/4/404/4568623

Some foods that help with detoxing.

https://www.curejoy.com/content/natural-foods-that-purify-blood/?utm_medium=IAR-MAR18&utm_source=FBFeed&utm_campaign=FBCJ

Some people use zeolite. We have to watch some zeolite is high in alluminum which can have a negative impact on our health.

https://link.springer.com/article/10.1007%2Fs12011-007-8039-x

Zeolite only detoxes cesium it does not detox heavy metals. Though it has been shown to help heal the gut but inhibits nutrient absorption. I believe using a good source of mucilage would be better and safer then using zeolite.

https://www.naturalnews.com/051805_zeolite_myths_heavy_metals_removal_daily_detox.html

Some waters that help detox aluminum from the brain.

http://realfarmacy.com/mineral-waters-remove-aluminum-from-brain/

Things that detox aluminum

https://thetruthaboutcancer.com/detox-aluminum-toxicity/

Problems of aluminum in the brain. Aluminum is used in vaccinations along with other toxins like formeldahyde.

https://www.askdrsears.com/topics/health-concerns/vaccines/vaccine-faqs

https://www.hindawi.com/journals/jt/2014/491316/

https://link.springer.com/article/10.1007%2Fs11011-017-0077-2

Aluminum causes oxidative stress.

https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-19-51

Aluminum damages the brain.

https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-8-41

Do things in moderation because too much vitamin D can damage the kidneys. Homeostasis is the goal.

https://www.healthline.com/nutrition/vitamin-d-side-effects#section7

If you drink bottled water you are consuming plastic. There are some that do not contain plastic particles.

https://www.nationofchange.org/2018/03/15/93-of-bottle-water-contains-microplastics/

Another source of plastic is pills and supplements.

https://www.peoplespharmacy.com/2014/05/05/is-there-plastic-in-your-pills/

Baking soda is great for detoxing.

https://www.ncbi.nlm.nih.gov/pubmed/27014821

Retinoic Acid reduces toxins from oxidative stress.

http://mcb.asm.org/content/29/12/3286.full

Detoxing helps with autism.

http://healing-arts.org/children/mtpromotion.htm

Your gut is the number one source of toxins entering the body.

https://experiencelife.com/article/autoimmune-disorders-when-your-body-turns-on-you/

Even feminine products have toxins now.

https://www.westonaprice.org/health-topics/health-issues/avoiding-glyphosate-in-feminine-hygiene-products/

Glyphosate residues are in our food.

https://www.omicsonline.org/open-access/survey-of-glyphosate-residues-in-honey-corn-and-soy-products-2161-0525.1000249.php?aid=36354

Because much of our food is high in glyphosate it makes us prone to food poisoning. This is why many feel like they have a brick in their gut after eating.

https://link.springer.com/article/10.1007/s00284-014-0732-3

If we are not producing enough bile we cannot detox.

https://metabolichealing.com/bile-deficiency-heartburn-poor-digestion-toxicity/

http://dmd.aspetjournals.org/content/34/4/513.long

https://febs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1742-4658.2011.08432.x

Lead and mercury lead to cancer. Though they claim vaccinations do not have mercury anymore some still do.

https://www.medicalnewstoday.com/releases/95154.php

https://www.sciencedaily.com/releases/2016/03/160310155052.htm

Luteolin protects from mecury toxicity.

http://journals.sagepub.com/doi/abs/10.1177/039463201002300406?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

BT Toxins in GMOs should be avoided.

http://www.i-sis.org.uk/BTTIGMC.php

http://whoismonsanto.com/gmos/gmo-corn

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209668/

https://enveurope.springeropen.com/articles/10.1186/s12302-016-0099-0

It is very possible for GMOs to effect our genes and the genes of our microbiome. That would make our body or the gut microbiome toxin factories.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1364539/

http://responsibletechnology.org/gmo-education/section5/

Burdock root and curly dock are great for detoxing.

https://draxe.com/burdock-root/

Honeysuckle is great for detoxing it even helps with fatty liver.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788397/

Symptoms of copper toxicity.

https://www.ncbi.nlm.nih.gov/pubmed/26417265

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464477/

Food additives we should avoid.

https://www.traditionaloven.com/articles/122/

We need to avoid fluoride it makes the teeth brittle.

https://link.springer.com/article/10.1007%2Fs10661-016-5219-1

Fluoride lowers IQ and causes many health problems.

https://www.researchgate.net/publication/291795479_Effects_of_endemic_fluoride_poisoning_on_the_intellectual_development_of_children_in_Baotou

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997496/

https://www.ncbi.nlm.nih.gov/pubmed/25556215

http://www.mdpi.com/1660-4601/13/3/259

https://fluoridefreesudbury.wordpress.com/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956646/

Fluoride works synergistically with aluminum.

https://www.ncbi.nlm.nih.gov/pubmed/26339156

Dandelion stimulates Dig1, Dig1 detoxes glyphosate.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987375/

Had to include my post on deep fried dandelion flowers.

http://www.instructables.com/id/Deep-Fried-Dandelion-Flowers/

How to detox glyphosate.

https://myersdetox.com/166-glyphosate-herbicide-and-how-to-detox-it-with-dr-stephanie-seneff/

Glyphosate damages the brain. Imagine what it is doing to babies because it has been found in the placenta.

https://www.sciencedirect.com/science/article/pii/S0300483X14000493

Glyphosate destroys the liver and kidneys from excess oxidative stress.

https://www.sciencedirect.com/science/article/pii/S1382668912001378?via%3Dihub

https://sciforschenonline.org/journals/neurology/JNNB-3-140.php

Glyphosate makes other things that are already toxic like folic acid not to be mistaken with folate more toxic.

http://autismcoach.com/glyphosate-folic-acid-oxalic-acid-vaccines-and-tylenol-wreak-metabolic-havoc-together/

https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-015-0109-2

Glyphosate is one of the main causes of modern day gut disorders.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/

https://realfoodforager.com/glyphosate-an-assault-on-your-microbiome/

https://pubs.acs.org/doi/abs/10.1021/tx015543g

Glyphosate persist in the environment and has been found in the atmosphere and in the rain so there is no way to avoid it and it persist for years.

https://link.springer.com/article/10.1007%2Fs11356-016-7425-3

You can test your glyphosate levels.

https://detoxproject.org/testing/glyphosate-testing-test-yourself/

Most know how toxic glyphosate is now. It is even in the meat we eat now.

https://www.researchgate.net/publication/261250327_Detection_of_glyphosate_residues_in_animals_and_humans

Glyphosate can causes diabetes.

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-1134-6

Our gut bacteria protect us from toxins. Roundup destroys them.

https://detoxproject.org/glyphosate/glyphosate-and-roundup-negatively-affect-gut-bacteria/

https://www.researchgate.net/publication/305318376_Glyphosate_pathways_to_modern_diseases_V_Amino_acid_analogue_of_glycine_in_diverse_proteins

Plants extracts that protect from toxins.

https://occup-med.biomedcentral.com/articles/10.1186/1745-6673-6-3

PON1 is needed for detoxing. Pesticides found in our foods inhibit PON1.

https://onlinelibrary.wiley.com/doi/abs/10.1002/tox.22253

https://www.selfhacked.com/blog/about-pon1-and-natural-ways-to-increase-it/

Things that detox ammonia from the body.

http://onibasu.com/wiki/Elevated_ammonia.html

Zinc detoxes ammonia from the body but too much will inhibit copper absorption and can have many bad side effects. I prefer getting it in my diet, for example honey is high in zinc.

https://aasldpubs.onlinelibrary.wiley.com/doi/abs/10.1002/hep.1840160326

https://www.curejoy.com/content/side-effects-of-taking-too-much-zinc/

Ethylene Glycol (antifreeze) is an ingredient in many vaccinations. Formeldahyde is also found in vaccinations and it’s use in building products was banned.

http://europepmc.org/abstract/MED/26647990

Read this PDF, imagine these things in your drinking water, would you drink it? Yet it is shot directly into our blood streams when vaccinated.

https://medel-la-production.s3.amazonaws.com/uploads/attach_document/document_file/59dd109e69702d7988870100/VAX_WATER.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203331/#!po=8.91892

We are exposed to toxins at work.

https://academic.oup.com/toxsci/article/73/2/423/1674370#.WK-i6VNP_FA.facebook

Fructose not to be confused with good fructose in fruits. Processed fructose causes non alcohol fatty liver diease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372893/

Fruits and vegetables with the most pesticides on them.

https://www.thestreet.com/slideshow/14449414/1/the-fruits-and-vegetables-with-the-most-pesticide-residue.html

Glutathione helps detox heavy metals.

http://www.immunehealthscience.com/glutathione-deficiency.html

https://livewello.com/library/glutathione-s-transferases-gstm1-gstt1-gstp1-genesid=6737166583988224

How to increase glutathione.

https://www.rheumatoid-arthritis-decisions.com/Foods-that-boost-glutathione.html

Muscle tremors can be a sign of low glutathione.

https://www.mcvitamins.com/glutathione.htm

Detoxing heavy metals.

http://www.lifeextension.com/Protocols/Health-Concerns/Heavy-Metal-Detoxification/Page-08

http://www.generationrescue.org/latest-news/metal-chemical-detoxification/

Endotoxins cause chronic illness. We get infections when something is in the body is out of balance. To fight the infection and to detox the endotoxins we need to work towards getting things back to homeostasis so the body can do it’s job.

https://docs.google.com/document/d/19UH1Jfe0qlPrKunC36yZVXZcuRLx_f8MslQdSXkV8pA/mobilebasic

http://www.townsendletter.com/June2012/anderson0612.html

Why it is difficult to detox endotoxin.

http://biotoxinjourney.com/block-detox/

The good and bad of chelating heavy metals.

https://drknews.com/chelation-autoimmunity/

When under a heavy toxin load even from endotoxins Fe3 is produced. The body cannot use this type of iron and it reduces our bloods ability to transport oxygen and causes many health problems. Lactoferrin, curcumin and lipocalin 2 will reduce Fe3 levels. Taking curcumin for too long can make a person anemic because it also chelates good iron. Lipocalin also reduces oxidative stress and helps clear pathogens from the body. Lipocalin also helps the heart heal. But high lipocalin levels can cause insulin resistance so we do not want to increase it but support it’s function with proper nutrients.

Lipcalin

https://link.springer.com/article/10.1007%2Fs10534-016-9925-5

https://www.nature.com/articles/srep35014

http://www.jbc.org/content/287/7/4808.full.html

http://diabetes.diabetesjournals.org/content/59/4/872

If we are insulin resistant it indicate high lipocalin levels. Cold and fasting stimulate lipocalin and phytic acid reduces lipocalin. So if we are insulin resistant we would not want to fast or expose ourselves to cold until we have gotten things back to homeostasis. We would also need to increase our phytic acid intake temporarily until we achieve homeostasis. Pushing things beyond homeostasis cause other health issues. We should always work towards homeostasis. Too much lipocalin promotes obesity, I need more lipcalin because I struggle to keep my bodies fat levels at a healthy level. Mine are way below what is considered healthy.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096997

https://www.nature.com/articles/s41598-017-15825-4

Lactoferrin

Lactoferrin protects us from infection and prevents pathogens from adhering to the gut. It also inhibits parasite infection in the vagina.

http://jfoodprotection.org/doi/pdf/10.4315/0362-028X-60.3.267?code=FOPR-site

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439953/

Lactoferrin helps maintain iron homeostasis.

https://www.sciencedirect.com/science/article/pii/S0300908408001958?via%3Dihub

http://www.mdpi.com/1422-0067/18/9/1985

Lactoferrins ability to chelate iron is the reason it reduces inflammation and helps prevent septic shock.

https://www.researchgate.net/publication/49685167_The_role_of_lactoferrin_in_the_iron_metabolism_Part_II_Antimicrobial_and_antiinflammatory_effect_of_lactoferrin_by_chelation_of_iron

https://publications.edpsciences.org/10.1051/medsci/2009254361

Because lactoferrin chelates Fe3 it reduces iron overload and restores iron homeostasis.

https://link.springer.com/article/10.1007%2Fs10534-014-9798-4

Curcumin chelates iron so can make anemia worse but will reduce symptoms of hypoferremia. If you have iron overload from oxidative stress, toxins or eating foods that have been fortified with Fe3 which is usually what they use then curcumin may help.

http://www.bloodjournal.org/content/113/2/270?sso-checked=true

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615657/

Nrf2 activators help with detoxing. Before using Nrf2 activators high in sulfur make sure your sulfide levels are down and you addressed metabolic issues or it could make you worse.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198074/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736808/

Spore based probiotics help protect us from endotoxins.

https://www.wjgnet.com/2150-5330/full/v8/i3/117.htm

How many pesticides effect the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943818/

Things that help detox pesticides.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470074/

Regulating our phytic acid intake so we reap the most benefits.

https://www.precisionnutrition.com/all-about-phytates-phytic-acid

Coconut oil helps detox cadmium.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787998/

Prussian blue and potassium iodide help protect us from radiation. Prussian blue also helps with heavy metal poisoning.

http://www.healthyfellow.com/808/potassium-iodide-and-prussian-blue/

http://www.townsendletter.com/Jan2016/thallium0116_2.html

Rose hips reduce oxidative stress thus preventing the toxins they produce.

http://www.ijkd.org/index.php/ijkd/article/view/891/556

Saffron helps protect from toxins.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418072/

Sweating helps reduce toxins. If you are not sweating then it indicates metabolic issues that need address.

http://naturalsociety.com/sweating-detoxing-body-heavy-metals-more/

Titanium dioxide causes cancer it is added to many products including our food to prevent it from sticking together.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423755/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408175/

It is very important to detox the lympatic system.

http://www.pureinsideout.com/detox-manual-lymphatic-drainage.html

https://theheartysoul.com/how-to-speed-up-lymph-flow/

Burdock is good for the lymphs.

https://draxe.com/burdock-root/

Acetaldehydes are produce from mold and fungal infections, molybdenum is needed to detox it. Once you reach homeostasis reduce intake and take maintenance doses too much manganese can have negative health effects. You may feel ill at first because as you detox the metabolic pathways for a short time the toxin levels will increase in our blood because it is cleaning out the detox pathways. We need to make sure we stay hydrated while detoxing so the liver and kidneys can better detox our bodies. Once the toxin levels come down in our metabolic pathways we will not get as sick. The body needs to transport the toxins out of our pathways somehow and the blood is how it does it.

http://www.ei-resource.org/articles/candida-and-gut-dysbiosis-articles/the-candida-aldehyde-detox-pathway-and-the-molybdenum-connection/

Deodorants link to cancer.

http://naturalsociety.com/how-to-do-an-armpit-detox-to-prevent-breast-cancer/

Proton pumps are bad for the body. The ironic thing is most indigestion is not caused by excess acid. It can be caused by high histamines, inhibited bile production, pyrrole issues which cause indigestion when someone consumes fats. Most things that cause indigestion cannot be addressed by proton pump inhibitors it only mask the symptoms while the body continues to decline.

http://mthfr.net/mthfr-mutations-and-antacids-are-a-bad-mix/2011/09/22/?utm_campaign=shareaholic&utm_medium=facebook&utm_source=socialnetwork

Bay leaf really reduced my nausea and toxin load, but there are other things sold as bay that can be toxic in high amounts but taste the same so make sure you have true bay leaf and not one of the others.

https://www.organicfacts.net/health-benefits/herbs-and-spices/bay-leaves.html

This is a form of dock, the dock family leaves and stems are high oxalate but the roots are great at detoxing. It only takes a couple little pieces in a cup of water.

https://www.tandfonline.com/doi/full/10.3109/13880209.2014.967782

Golden Rod is great at detoxing but it also kills many types of pathogens so I herx when I first used it and had to ease into it.

https://www.healthbenefitstimes.com/canadian-goldenrod/

Here is a description of a herx reaction. I experienced nausea, drowsines, pain and confusion.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239707/

I usually don’t promote products but Dr. Ben Lynch is the most knowledgeable in my opinion on the genes and correcting issues involved with them. I believe this book is one of the best.

http://go.dirtygenes.com/books

Detoxing the pineal gland.

https://scottjeffrey.com/pineal-gland-detox-supplements/

Calcium D-glucurate helps detox many things including ammonia and biotoxins from mold.

https://blog.bulletproof.com/calcium-d-glucarate/

I have posted on sulfation and oxalates. If we have issues with those we must address them or we cannot detox.

https://mthfrsupport.com/2016/02/impacts-to-our-snps-via-foodtoxins-and-the-resulting-domino-effect-on-their-genetic-expression/

Foods that increase UDP-glucuronosyltransferase.

http://dmd.aspetjournals.org/content/30/5/564

https://www.heart-health-guide.com/apigenin.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874462/

https://www.selfhacked.com/blog/apigenin-top-11-science-based-health-benefits-apigenin/

Luteiolin is good at increasing UDP-glucuronosyltransferase.

http://secretsofnaturalhealing.blogspot.com/2010/12/luteolin-rich-foods-shown-to-reduce.html

https://www.selfhacked.com/blog/top-11-science-based-health-benefits-luteolin/

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166239

Diosmetin is found in the white parts of citris fruit and dates.

https://pubs.acs.org/doi/abs/10.1021/jf502359x?src=recsys&journalCode=jafcau

https://www.researchgate.net/publication/228115816_Bioactivity_of_Diosmetin_Glycosides_Isolated_from_the_Epicarp_of_Date_Fruits_Phoenix_dactylifera_on_the_Biochemical_Profile_of_Alloxan_Diabetic_Male_Rats

How Glyphosate effects the gut and health of the body.

https://detoxproject.org/glyphosate/glyphosate-and-roundup-negatively-affect-gut-bacteria/

http://www.mdpi.com/1099-4300/15/4/1416

https://www.ncbi.nlm.nih.gov/pubmed/25245870

https://people.csail.mit.edu/seneff/SamselSeneffGlyphosateIV.pdf

https://www.researchgate.net/publication/305318376_Glyphosate_pathways_to_modern_diseases_V_Amino_acid_analogue_of_glycine_in_diverse_proteins

http://www.amsi.ge/jbpc/11717/25SA16A.pdf

I have posted on sulfites and sulfation. If we have high sulfite levels or we have sulfation issues it can cause heart disease. Sulfur is very important for regulating many things throughout the body including hormones and blood pressure. Glyphosate, glufosinate and mercury inhibit sulfation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725894/

This can effect BH4 levels. Green Tea raises BH4 levels but must be used in moderation because over use can raise histamine levels.

http://www.j-circ.or.jp/english/sessions/reports/71st/sym10.htm

http://www.life-enhancement.com/magazine/article/3721-green-tea-re-establishes-tetrahydrobiopterin-levels-in-human-diabetics

https://www.fasebj.org/doi/abs/10.1096/fasebj.30.1_supplement.737.6

Detoxing Glyphosate.

 

https://myersdetox.com/transcript-166-glyphosate-and-how-to-detox-it-with-dr-stephanie-seneff/

 

https://drhedberg.com/the-liver-detoxification/

 

Lyme detoxing, I also posted on endotoxemia which covers Lyme.

 

http://lymeology.com/lyme-detox-guide/

 

Detoxing mold.

 

http://www.newhealthoptions.org/?page_id=617

 

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Dealing With Endotoxemia or Sepsis.

This is not medical advice , I am posting this for educational and informational purposes.

These are my notes of things I researched to recover. I have much more to add to it but figured I would post what I have typed up so far. This is not in order and inflammation is very very important to address in order to be able to detox endotoxins.

https://docs.google.com/document/d/19UH1Jfe0qlPrKunC36yZVXZcuRLx_f8MslQdSXkV8pA/mobilebasic

This is not medical advice, I am putting this here for informational and educational purposes. My advice on reading this because it is very long is skip over things that do not seem to concern you and the issues you are dealing with. I had many health problems I had to deal with and these are my notes. It seems I had more then usual so my notes are extensive. From what I am learning most do not experience the number of health issues I had. I need to cover oxidative stress first because it is the main cause of the symptoms of sepsis.

Many take CoQ10 for their fatigue. I would say it is better to avoid but supporting NADPH might be a better option. I noticed I got worse when I took CoQ10 but Ubiquinol seemed to work fine for me.

https://www.hindawi.com/journals/omcl/2011/194586/

Oxidative Stress

Oxidative Stress is caused by an imbalance in our antioxidant system. When there is an imbalance taking antioxidants will increase the damage in the body. We must address what is causing the imbalance before taking antioxidants. Taking antioxidants when there is an imbalance in the antioxidant system also makes us more prone to health issues especially cancer. An imbalance in or inhibited redox cycling and blocked Nrf2 pathways are the most common issues involving excess oxidative stress.

This results in the production of peroxides and free radicals. This damages components of the cells including lipids and DNA , they cause strand breaks in the DNA preventing it from repairing . This is why high LDL levels are a sign of oxidative stress. High cholesterol indicates an imbalance in the antioxidant system. This can be caused by toxins like heavy metals, the many farm chemicals found in our food, toxins in processed food, heavy metals, infections and the endotoxins from dying pathogens, many of the toxins in vaccinations can cause oxidative stress,and stay in the body a very long time, especially the aluminum in vaccinations. To restore balance we need to detox whatever is causing the imbalance, also address any metabolic issues causing the imbalance. The hydrogen peroxide produced from the reactive oxygen species can act as cellular messengers which cause a disruption in normal mechanism in cell signaling. This causes redox cycling to be inhibited and has been linked to many forms of chronic illness. Nrf2 regulates the antioxidant system and toxins, infection and bad diets can inhibit the Nrf2 pathways. Excess oxidative stress causes adenosine triphosphate (ATP) depletion. ATP is important in molecular cellular energy transfer. This causes apoptic cell death to be inhibited so the cell simply falls apart. When the cell is not removed by apoptosis it can cause a build up of cellular debris in the body which has many negative health effects. Inflammation can inhibit the bodies ability to remove toxins and waste which can contribute to oxidative stress. Over production of ROS can lead to stroke, hypertension, hardening of the arteries, heart attacks, and failure of organs. It can result in damage to the brain resulting in impaired thinking and even mental illness.

There are many sources of reactive oxygen species in the body. Xanthine Oxidase is an enzyme that generates reactive oxygens species it is found in the blood and lungs. It’s activity is increased during infection. Levels of xanthine oxidase are increased during liver damage. It has been found to be high in gout. Phytic acid inhibits xanthine oxidase. Remember homeostasis is the goal because the antioxidant system protects us we do not want to keep inhibiting it. Once we get inflammation down and the peroxide, and free radical levels down we want to maintain homeostasis.

Free radical from oxidative stress deplete cofactors involved in electronic transport, DNA repair. Damaged (Fe-S) clusters can cause iron overload. It also causes inhibition of lipoic acid synthase which is involved in amino acid metabolism and glycine degradation. When inhibited it results in encephalitis and lactic acidosis. This also causes a build up of hydroxyl radicals. NADPH oxidase is activated by infections and certain cytokines. Arachidonic acid (omega 6) also stimulates activity of NADPH oxidase Apocynin found in many plants inhibits NADPH oxidase. I do not know which plants but most research papers state apocynin found in many types of plants. Inhibition of NADPH can cause granulomas to form. This is the bodies way of blocking off something it cannot rid from the body. So do not over do it. Nitric Oxide also inhibits NADPH oxidase. Arginine and citrulline can help increase NO.

http://www.mdpi.com/1420-3049/18/3/2821/htm

Superoxide Dismutase

Superoxide Dismutase comes in three forms in the body, SOD1 is located in the cytoplasma inside of cells, SOD2 located in the mitochondria, SOD3 is extracellular. SOD serves as a key antioxidant. Low SOD levels increases the risk of cancer. SOD has anti-inflammatory effects. SOD decreases ROS and oxidative ss, and interstitial cystitis. It also reduces inflammation in the urinary tract. SOD also prevents liver and kidney damage and protects us from radiation damage. The most bioavailable form of of SOD is found in the chaga mushroom but it is also found in phytoplankton, horseradish, and cantaloupe. If you have iron toxicity it will inhibit SOD. Lactoferrin helps restore the bad iron back to good and helps the body get rid of excess iron. Curcumine chelates iron but if taken to often or too much it can cause anemia. Infection can cause the body to store copper in our soft tissue to prevent pathogens from using iron. This also prevents the body from using iron, it kills the pathogen but inhibits SOD production. Natural sources of vitamin C will get the body to release the copper from the soft tissue. High doses of vitamin C can cause red blood cells to break down so don’t get carried away. Also man made vitamin C can cause oxalates. Manganese is needed for SOD production but should not be taken in high doses it can be toxic if we get too much in the body. Zinc is also needed for SOD production , honey is high in zinc.

Low SOD3 can cause acute respiratory distress syndrome which is when fluid leaks into the lungs. It has also been linked to COPD.

Glutathione and SOD are tightly linked so I will cover it next. Resveratrol also activates SOD it is found in grape seed extract.

We need to find balance because high levels of SOD has been show to make us susceptible to certain types of cancer. Homeostasis should be the goal then do things to maintain homeostasis.

http://www.immunehealthscience.com/superoxide-dismutase.html

https://www.selfhacked.com/blog/the-brain-fog-gene-rs4880-or-sod2/

http://jcb.rupress.org/content/early/2018/04/17/jcb.201708007

Glutathione peroxidase

Glutathione peroxidase is a general name for a group of enzymes with peroxidase activity. Gps main biological role is to protect from damage from oxidative stress. GP reduces lipid hydroperoxides to their corresponding alcohols. Lipid hydroperoxides are caused from the oxidative degredation of fats. It mostly effects polyunsaturated fatty acids. There are several documented cases of anemia from GP deficiency, most likely if they measure the Fe3 iron it would be high. The iron in the plasma was probably in a form the body could not us.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159114/

http://omim.org/entry/614164

GPx1 increases reactive nitrogen species ability to cause cell death and can cause insulin resistance. So it is important to make sure reactive nitrogen species are not high.

https://link.springer.com/chapter/10.1007/0-387-33827-6_16

http://www.jbc.org/content/276/46/43004.full

How Nitric Oxide Species are produce.

https://www.sciencedirect.com/science/article/pii/S0005272899000286

This is a link to a more in depth article I did on Nitrosative Stress.

https://iamajuicer.wordpress.com/2018/07/11/nitrosative-stress/

If you have been reading the links in my post you know by now that lipopolysaccharides a component of endotoxins is responsible for the systematic inflammation that endotoxins cause. Lipopolysaccharides are a component of many pathogens.  It is very important to reduce the level of LPS in the body to reduce chances of sepsis which results in chronic illness. LPS can cause a bunch of issues that prevent us from detoxing which causes many other issues. In order to detox LPS we need to address those issues. I am going to place these links here so when you decide the approach you may want to take you can look at nutritional options that may help after you have read the article and get a better understanding of endotoxemia these can be used for a reference.

https://iamajuicer.wordpress.com/2018/06/23/supplement-and-nutrient-information-i-have-accumulated/

https://iamajuicer.wordpress.com/2018/06/26/supplement-and-nutrient-information-i-have-accumulated-part-2/

It is very important to reduce LPS because it has a dramatic effect on our brain. It can cause anxiety, dissociative behavior, emotional dysfunction. It also impairs memory. It can cause fatigue and even disrupt the reproductive cycle. High LPS levels have been linked to things such as diabetes, heart disease, mental illness, cancer, obesity, metabolic disorders, renal disorders, autism, hearing and eye health can be negative impacted. LPS also cause digestive disorders like SIBO, IBD, IBS and dysbiosis. LPS contributes to arthritis and increased allergies. LPS has even been linked to PCOS in women. LPS causes adrenal fatigue. It can cause many skin disorders like lupus or psoriasis. It can contribute to bone loss. It causes neurological damage throughout the body.

Endotoxins also cause hormone imbalances and thyroid problems.

There are gut bacteria that reduce LPS, Bifidobacterium, Lactobacillus GG, Saccharramyces Boulardii Bacillus Infantis, B Longhum, Clostridium Butyricum, E Coli Nissle 1917, Lactobacillus Brevis, L Casei, and many others.

https://www.ncbi.nlm.nih.gov/pubmed/23568206

Fruit pectin reduces LPS. The pectin is the waxy substance found on the skins of many fruits. One of these articles mentions corn flakes. Corn is GMO and causes leaky gut which would make things worse. I do not recommend eating any GMOs they themselves can cause sepsis.

https://www.ncbi.nlm.nih.gov/pubmed/16930561

http://healthyeating.sfgate.com/fruits-high-pectin-9671.html

https://www.dietaryfiberfood.com/dietary-fiber/pectins.php

Exercise reduce LPS.

https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-015-0362-0

Stimulating the vagus nerve decreases LPS and inflammation.

https://www.hindawi.com/journals/ecam/2012/627023/

https://thelivingproofinstitute.com/19-ways-to-stimulate-your-vagus-nerve/

https://theheartysoul.com/ways-to-stimulate-your-vagus-nerve/

Polyphenols reduce LPS. These are usually highest in darker colored fruits and vegetables.

https://academic.oup.com/ajcn/article/79/5/727/4690182

Resistant starch decreases LPS by increasing the good gut bacteria. This should be introduced slowly because when the good gut bacteria increase the bad die off which will cause bloating and herxing. I got very ill when I tried to eat resistant starch. I had to start with small amounts and slowly increase my intake.

http://drhyman.com/blog/2016/03/24/the-starch-that-makes-you-lean-and-healthy/

https://www.karger.com/Article/FullText/477386

LPS and Fats

Diets high in bad fats, like transfats and saturated fats increase the effects of LPS.

These sites suggest ways to reduce LPS. I do not agree with all their methods so always take things with a grain of salt and do your research. Many have metabolic issues that need addressed before taking some of the suggested things in these articles. For example those with high sulfite levels or CBS or BH4 issues would become ill from some of the things suggested because they are high in sulfur. Those with Pyrrole issues will become ill from any types of fats so Omega 3s will cause problems. So before you can even attempt to detox LPS you need to address any metabolic issues or you will be running on a hamster wheel of ill health getting no where because the things needed to heal will make you ill.

https://www.selfhacked.com/blog/lipopolysaccharides/

https://mybiohack.com/blog/lipopolysaccharide-endotoxins-lps-tlr4

LPS Causes Leaky Gut

LPS causes leaky gut, leaky gut causes our bodies to absorb more LPS. Here is another area where the cycle must be broken. Just as with high oxalate levels it is difficult to heal the gut , high LPS levels make it difficult to heal the gut. I have posted articles that will help with information on healing the gut so I will not cover it in detail but if time permits I will post the links to the articles. Healing the gut is very important in order to break the cycle.

https://www.naturalmedicinejournal.com/journal/2010-03/nutritional-protocol-treatment-intestinal-permeability-defects-and-related

https://www.mindbodygreen.com/0-15971/why-a-leaky-gut-will-wreck-your-health-what-to-do-about-it.html

https://www.selfhacked.com/blog/lipopolysaccharides/

These are articles I did that have information that may help with leaky gut.

https://iamajuicer.wordpress.com/2018/06/28/leaky-gut-oxalates-and-more-supplement-information/

https://iamajuicer.wordpress.com/2018/06/27/its-not-your-genes-it-is-your-gut-microbiome/

Activated charcoal helps reduce LPS but should not be taken to soon after eating. It will inhibit nutrient absorption.

https://fixyourgut.com/dysbiosis-causing-illness-try-activated-charcoal/

If the leaky gut is not addressed we develop metabolic endotoxemia.

https://paleoleap.com/metabolic-endotoxemia-one-link-between-gut-problems-and-obesity/

Polyunsaturated fats should be avoided. The body only needs a small amount of them. When the levels get to high in the body they negatively impact our health. These are found in things such as corn oil, canola oil, cotton seed oil, and soybeen oil. They also contain transfats which really need to be avoided. Fats from things like fresh cod liver oil which should be refrigerated. If it smells fishy then it has oxidized and has lost some of it’s benefits, other sources are coconut oil, beef tallow,lard and butter contain the fats that our bodies need. The tallow, lard and butter should be from grass feed beef. We need PUFAs in our diet but in the form of Omega 3s. We have to do our best to prevent the Omega 3s from oxidizing. The previously mentioned oils are high in Omega 6 , our Omega 3 levels should be higher then Omega 3s but processed food is high in Omega 6 and is why many have inflammatory diseases.

http://butterbeliever.com/what-is-pufa/

https://www.medpagetoday.com/primarycare/dietnutrition/50978

It is very important to protect the liver while detoxing endotoxins because it is hit pretty hard and can get damaged. Burdock root and sarsparilla root seemed to help me. Rooibos tea was another herb that really helped me, it is great for oxidative stress and inflammation. Sculletaria is another one that seemed to really help me. Bayberry has also been found to support the kidney and liver.

https://ccforum.biomedcentral.com/articles/10.1186/cc5013

https://www.betternutrition.com/natural-rx/herbaldetox

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-392

https://www.sciencedirect.com/science/article/pii/S2221169115001410

Here is a very good article explaining detoxing.

https://www.selfhacked.com/blog/the-science-of-detoxification/

Oxidative Stress

Endotoxins cause oxidative stress which results in the oxidation of lipids. The can result in damage throughout the body and is why many have high oxLDL levels. High LDL is a symptom not a cause. It is very important to also address the oxidative stress caused by endotoxins. This includes restoring the balance of our gut bacteria which protects us from oxidative stress. If they are out of balance they can actually contribute to oxidative stress. It is why those who take the same probiotic daily usually end up sicker. They get too much of specific strains of gut bacteria and are preventing their gut bacteria from balancing out. Cholesterol is an antioxidant and an anti-inflammatory. Reducing cholesterol would do the opposite of what we want. It would increase inflammation and prevent the body from healing.

https://www.researchgate.net/profile/Guillermo_Tellez/publication/286285603_Mechanisms_involved_in_lipopolysaccharide_derived_ROS_and_RNS_oxidative_stress_and_septic_shock/links/569593d908ae425c68985bfa/Mechanisms-involved-in-lipopolysaccharide-derived-ROS-and-RNS-oxidative-stress-and-septic-shock.pdf?origin=publication_detail

https://www.ncbi.nlm.nih.gov/pubmed/27718209

http://atvb.ahajournals.org/content/23/7/1133

Vitamin E reduces oxidative stress from LPS but the most effective is a-tocopherol. A-tocopherol is found in wheat germ, liver, egg yolk and nuts. Green leafy vegetables are high in it but most are high oxalate especially spinach so must be cooked to break down the oxalates. I have posted on supplements so I will not get into detail but will list the most effective ones here.

http://healthyeating.sfgate.com/foods-high-alphatocopherol-3483.html

https://www.healthline.com/nutrition/foods-high-in-vitamin-e#section1

Nicotinamide reduces oxidative stress from endotoxins.

https://www.ncbi.nlm.nih.gov/pubmed/29803807

Foods that help increase nicotinamide are milk , yeast , mushrooms,fish, green vegetables and beer. Most beer is GMO it must be organic because the harm GMOs do would defeat the purpose.

https://www.superfoodly.com/nicotinamide-riboside-food-sources/

https://greatperformersacademy.com/health/7-foods-that-will-naturally-increase-nad-and-restore-your-youth

Lycopene reduces oxidative stress. Foods high in lycopene are tomatoes, watermelon, guava, papaya, sweet red peppers, purple cabbage, and mango. Some foods like tomatoes when cooked increases the amount of lycopene the body absorbs.

https://www.ncbi.nlm.nih.gov/pubmed/29454265

https://www.myfooddata.com/articles/high-lycopene-foods.php

https://draxe.com/lycopene/

Carbon dioxide reduces LPS damage but increasing it has to be done with caution. You can increase carbon dioxide by breathing into a paper bag for a short period of them. I would not do this for long though. It takes a while for oxygen levels to return to normal. I do not recommend trying this I put it here for others to research farther. Those with COPD, asthma, or lung damage would not fair well doing this.

https://www.ncbi.nlm.nih.gov/pubmed/29907213

https://chronicfatigue.livejournal.com/60641.html

http://smart-breathe.com/carbon-dioxide/

Because LPS increases estrogen because it prevents the body from detoxing it, it is important to decrease estrogen. Some medications increase estrogen, stress increases estrogen, nutrient deficiencies increase estrogen, environmental toxins can increase estrogen, emotional stress can increase estrogen. Many view estrogen as a female hormone, men can have high estrogen levels also. Oxidative stress caused by LPS causes nutrient deficiency which prevents the body from detoxing estrogen. It is very important to get the nutrients we need. Especially minerals and fats. Flouride, fluoroquinolones, farm chemicals especially glyphosate increase estrogen. It is best to eat organic when possible. Sunlight helps detox estrogen when we get it in moderation. Those who avoid getting sun have higher rates of cancer. Those who get too much sun have higher rates of kidney stones. So moderation is the key. There is not much research on reducing estrogen but when the other things are addressed and the detox enzymes are functioning again your body will detox the excess estrogen. Fiber also lowers estrogen. High estrogen levels cause lipid oxidation this can result in high triglyceride levels. High tryglycerides are a symptom and not a cause.

https://butternutrition.com/estrogen-dominance-hormonal-imbalance/

http://www.cheeseslave.com/balancing-hormones-naturally/

https://www.ncbi.nlm.nih.gov/pubmed/8039147

B vitamins are very important in detoxing estrogen. When taking folate do not confuse it with folic acid which is man made and has many negative effects on the body.

http://main.poliquingroup.com/ArticlesMultimedia/Articles/Article/801/10_Ways_To_Lower_Estrogen_Toxic_Load_.aspx

https://hormonesbalance.com/articles/b-vitamins-for-your-hormones/

https://testosteroneresource.com/tboosting-ingredients/vitamin-b6/

Inflammation

It is important to reduce inflammation. Inflammation can inhibit bile, inhibit the bodies ability to detox, it also can cause autoimmune disease. Bile detoxes many things in the body including LPS and it prevents it from entering the body through the digestive tract. If you get constipated or it feels like you have a brick in your stomach after eating then you may have inhibited bile production. This will cause you food to sit in the upper part of the digestive tract and it will ferment instead of digesting which causes many health problems. Cholesterol is needed to produce bile. If we have excess oxidative stress our cholesterol will get oxidize and it is another reason we must address oxidative stress and reduce it. Fats are also needed to produce bile, this also gets oxidized from oxidative stress. Also the metabolic issues like porphyria can cause problems with fat metabolism and is why it is very important to address metabolic issues. I have posted supplements that help with these issues. If you look through the list COX , inhibitors, anti-inflammatory nutrients will help to reduce inflammation. There are many things involved in the production of bile. Even our gut bacteria modulate bile production. Inhibited bile production can also cause problems with the gall bladder. Sulfation is also important factor in bile production so if you have high sulfite levels from gut dysbiosis, candida, CBS or BH4 issues then you need to address those also. Polyunsaturated fatty acids cause a decrease in the livers ability to detox estrogen.

Things that increase bile are lemon water, artichoke, dandelion root, foods high in sulfur. Taurine deficiency which is common in vegetarians can cause inhibited bile production. Taurine has been shown to increase bile flow.

https://www.belmarrahealth.com/bile-function-liver-foods-help-increase-bile-production/

https://www.ncbi.nlm.nih.gov/pubmed/3655556

Our gut bacteria also can cause inflammation if we are deficient in certain strains.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839080/

Bile

Bile aids in the absorption of healthy fat. If we have poor bile production it can have dramatic effects on the whole body. Every cell in the body needs fat, the brain is mostly fat so fat malabsorption effects the whole body.

https://empoweredsustenance.com/fat-malabsorption/

Many think their indigestion is from acid reflux but often times it is from inhibited bile production. Inhibited bile could cause a deficiency in fat soluble vitamins especially vitamin K. Antibiotics also reduce the gut bacteria that produces vitamin K which can add to the problem.

https://metabolichealing.com/bile-deficiency-heartburn-poor-digestion-toxicity/

This is a very in depth article on bile.

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1105662

Adrenal Fatigue

Endotoxins damage betadorphin nerves in the hypothalamus. This results in raised cortisol levels. This is another reason why it is very important to address inflammation. This results in insulin resistance and suppressed progesterone production. LPS causes high histamine levels , progesterone and testosterone are needed to protect us from histamines. There is supplements mentioned in my post on supplements that discusses ways to reduce histamines this is also cover in my post on how our gut bacteria effect our genes. We have histamine reducing bacteria. Adaptogenic herbs help with the adrenal fatigue caused by LPS.

http://www.mdpi.com/1422-0067/18/7/1431

Kupffer Cells

LPS stimulates liver kupffer cells which can cause a rise in reactive oxygen species and inflammatory cytokines. The body can get stuck in a cycle that escalates and the inflammation and oxidative stress will keep increasing. This is why it is very important to address oxidative stress, inflammation and work on detoxing LPS and excitotoxins so the cycle can be broken and healing can begin. If not broken this can result in liver fibrosis. Because kupffer cells are needed to detox LPS we do not want to inhibit them but we need to detox, and address metabolic issues and oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748178/

http://iai.asm.org/content/67/10/5409.full

Bradykinin

Bradykinin – it is a peptide that causes blood vessels to dilate, which decreases blood pressure. Bradykinan stimulates the release of Nitric Oxide, Postacyclin, Endothelium-derived hyperpolarizing factor. This allows the smooth muscle to relax , increasing their diameter which reduces blood pressure. Bradykinin raises internal calcium levels in neocortical astrocytes. Astrocytes fuel neurons with energy during times of stress , physical exertion, and periods of fasting. They are important in the flow of blood to the brain. Astrocytes clear excess postassium in extracellular space. Excess potassium can cause epilepsy. Astrocytes in the hippocampus suppress synaptic transmition by releasing ATP which through a number of processes produces adenosine. Adenosine prevents tachycardia. Astrocytes promote the healing of nerves but if over stimulated can cause nerve damage. Astrocytes can also promote nerve cell and brain cell growth. ACE inhibition raises bradykinin and causes the dry cough people get from taking ACE inhibitors. High bradykinin levels causes asthma, and swelling in legs , face, and abdomin. High bradykinin levels also causes vomiting and airway obstruction. Bromelain, aloe vera, and polyphenols reduce the effects of bardykinin.

HPA axis is important in the homeostasis of bradykinin.

https://www.ncbi.nlm.nih.gov/pubmed/?term=26468906

This is an description of bradykinin and the health effects.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658795/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518251/

bradykinin prevents blood clotting.

https://www.ncbi.nlm.nih.gov/pubmed/?term=26517864

Bradykinin can increase inflammation in our lungs during infections.

https://www.ncbi.nlm.nih.gov/pubmed/22935637

So we can see not enough bradykinin can effect our health as much as too much bradykinin. Homeostasis should be the goal with all our health goals. Once we reach homeostasis then we need to work towards maintaining it to prevent over doing things which can cause just as much harm.

http://www.nwpii.com/ajbms/papers/AJBMS_2011_2_09.pdf

High bradykinin levels can cause low blood pressure, tachycardia, blood vessel leakage, it can cause inflammation especially in the salivary glands. Bradykinin also raises substance P which causes burning in the scalp and down the spine, also can be felt in the skin and increases at night. ACE inhibitors raise bradykinin levels.

https://www.pharmacorama.com/en/Sections/Angiotensin_2.php

https://www.news-medical.net/health/ACE-Inhibitor-Side-Effects.aspx

Glycosides like astilbene and eurcrypin inhibit bradykinin. Also keep in mind histamines and inflammation stimulate bradykinin so we must reduce those also. Most plant polyphenols will reduce bradykinin especially grapes and the white part of citrus fruit. Also if we do not have high sulfite levels , high sulfur foods reduce bradykinin.

http://www.scielo.br/pdf/mioc/v86s2/vol86(fsup2)_182-189.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/

Hormones and their effects.

Adenosine- is involved in the regulation of blood pressure. If deficient a person could develop high blood pressure and tachycardia. It reduces inflammation by suppressing the activity of most immune cells. A deficiency can be caused by excess inflammation and immune responses. This can result in muscle fatigue. D-ribose has been found to help reduce the fatigue. So those with lung disease , cardiovascular disease or low immune function could be effected by adenosine.

Symptoms of adenosine deficiency would be muscle fatigue will exercising and frequent infections in the lungs. A deficiency in adenosine causes a loss of T regulatory cells. Symptoms of this are conditons such as eczema , and also type 1 diabetes. Adenosine deficiency also causes hypoxia. Excess adenosine can result in asthma. When cells are stressed or damaged adenosine increases. This is why I freqently say homeostasis should always be the goal. Those with low adenosine may have trouble sleeping.

https://www.sciencedirect.com/science/article/pii/S0167488916300842

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1276958/

Lactobacillus Reuteri helps reduce the symptoms from adenosine deficiency.

http://3dsbiovia.com/blog/index.php/2017/08/23/exploring-treatment-options-ipex-patients-gut-microbiome-insufficiencies/

http://jem.rupress.org/content/214/1/107

Excess adenosine and the complications from it. This is a caused by a deficiency in adenosine deanamase.

Causes Asthma and other lung inflammatory diseases.

https://www.ncbi.nlm.nih.gov/pubmed/26232643

https://www.ncbi.nlm.nih.gov/pubmed/12559769

Gotu Kola contains asiatic acid which helps with ada deficiencies.

https://www.ncbi.nlm.nih.gov/pubmed/29805609

Excess adenosine can cause prolonged painful penile erections which can result in damage to the penis.

https://www.fasebj.org/doi/abs/10.1096/fj.13-247833

Adenosine signaling is elevated in sickle cell anemia. Increasing Adenosine Deaminase would help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351509/

Hyeprthyroidism causes raised adenosine levels showing that we must protect the health of the thyroids.

https://www.ncbi.nlm.nih.gov/pubmed/7596349

Adenosine Deaminase breaks down adenosine. A deficiency causes many health problems because of raised adenosine levels. It can lead to skeletal issues, mental deficiencies, immune dysfunction, and hearing loss.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916829/

https://link.springer.com/article/10.1007%2Fs10875-018-0496-9

Curcumin inhibits ADA so should be avoided by those who have low ADA levels. There are nutrients that help support ADA production.

https://www.selfhacked.com/blog/about-adenosine-and-the-adenosine-deaminase-gene-rs73598374/

https://www.mygenefood.com/genes/ada/

Hypothyroidism causes reduce adenosine levels.

https://www.ncbi.nlm.nih.gov/pubmed/15811553

AdA levels can effect thyroid health.

http://www.thetrp.net/article.asp?issn=0973-0354;year=2015;volume=12;issue=3;spage=104;epage=106;aulast=Duwal

adenosine restores neutrophil chemotaxis endotoxins inhibit the bodies ability to locate infections. Adenosine restores this ability.

https://link.springer.com/article/10.1007/s00011-016-1021-3

Adiponectin

Adiponectin is a protein hormone involved in regulating glucose levels in the body. It plays a role in the endocrine system, and metabolic and inflammatory signaling. Issues with adiponectin have been tied to ADHD, diabetes, and arthritis. Those who have type 2 diabetes, obesity, hyperlipodemia, and arthritis have been shown to have low adiponectin levels. Those with low adiponectin have a higher risk of cardiovascular disease.

Adiponectin protects us from cardiac injury from endotoxins.

https://www.hindawi.com/journals/bmri/2014/382035/

http://www.jimmunol.org/content/182/10/6444

Adiponectin is produced in fat cells and muscle cells.

http://care.diabetesjournals.org/content/26/8/2442

https://www.ncbi.nlm.nih.gov/pubmed/24417944

EPA and DHA increase adiponectin.

https://www.ncbi.nlm.nih.gov/pubmed/25900100

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085721/

Palmitic acid increases the brown fat needed to produce adiponectin.

https://www.ncbi.nlm.nih.gov/pubmed/29654827

Chrysin found in high levels in flowers and honey increases brown fat.

https://www.ncbi.nlm.nih.gov/pubmed/27133810

Those with low adiponectin have a higher risk of cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pubmed/20096841

https://www.ncbi.nlm.nih.gov/pubmed/2905203

Phytic acid improves adipose differentiation improving the function of brown fat this improves insulin sensitivity. Phytic acid is found in grains and nuts. Eat food high in phytic acid in moderation it is an anti nutrient. Phytic acid also reduces sepsis.

https://www.ncbi.nlm.nih.gov/pubmed/25174657

https://www.ncbi.nlm.nih.gov/pubmed/17412285

The importance of improved cell differentiation in our brown fat is that it regulates the homeostasis of many things within out bodies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864949/

So here is how to increase brown fat.

https://getloss.com/weight-loss/strategies/how-to-increase-adiponectin.html

https://www.wikihow.com/Increase-Adiponectin

Our diet influences our adiponectin levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400715/

Alpha-Melanocyte Stimulating Hormone

Alpha-Melanocyte Stimulating Hormone- it is an endogenous hormone and neuropeptide. It is one of the proteins responsible for hair and skin pigmentation. It plays a role in our feeding behavior, energy homeostasis in the body and even our sexual activity. It protects from injury that results from restricted blood flow, it also protects from the injury that results when the blood flow is restored. When blood flow has been restricted and then is restored it results in oxidative stress and inflammation. It also has antimicrobial properties.

https://www.selfhacked.com/blog/alpha-msh-its-role-in-weight-control-autoimmunity-cirs-and-cfs/

https://www.moldillnessmadesimple.com/cirs-melanocyte-stimulating-hormone-msh/

https://www.hindawi.com/journals/bmri/2014/874610/

https://www.atsjournals.org/doi/full/10.1164/rccm.200303-372OC

It helps prevent sepsis.

https://academic.oup.com/endo/article/144/1/360/2501731

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698338/

Glucose stimulates a-msh production which helps regulate glucose homeostasis.

https://www.sciencedirect.com/science/article/pii/S2212877816301028

Excess oxidative stress depletes a-msh.

http://www.ijbs.com/v13p0391.htm

It also protects us from the Nrf2 inhibiting effects of UVB rays thus protecting us from oxidative stress.

https://academic.oup.com/endo/article/150/7/3197/2456152

Low a-msh results in increased appetite, inflammation, increased pain, difficulty sleeping, and dehydration which results in low blood pressure from the excessive water excretion. Vaccinations, heavy metals, fluoride,fluoroquinolone drugs, glyphosate and other farm chemicals damage the pineal gland which has effects on the levels of a-msh. We also have a higher risk for cancer when it is low.

http://www.yourhormones.info/hormones/melanocyte-stimulating-hormone/

https://www.globalhealingcenter.com/natural-health/everything-you-wanted-to-know-about-the-pineal-gland/

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008958

It improves the bodies ability to heal.

https://www.ncbi.nlm.nih.gov/pubmed/25431356

This is why it is very important to get sun light in moderation. Sun light controls homeostasis of many body functions and is a much needed nutrient. Yes I am calling it a nutrient. It is the best way to describe sun lights effects on the body.

https://www.ncbi.nlm.nih.gov/pubmed/29546369

I am not certain what the effects on those suffering from Addison’s disease would be but they produce it in excess. Excess a-msh can cause a loss of appetite even cause nausea and vomiting, weakness, hypotenion and liver fibrosis.

https://www.ncbi.nlm.nih.gov/pubmed/2855222

Brain Nutriuretic Peptide

Brain Nutriuretic Peptide – is a hormone secreted in heart muscle cells. It reduces blood pressure, it reduces renal sodium reabsorption and increases the break down of fats. It reduces the release of aldosterone in the adrenal cortex. Aldosterone causes a reabsorption of salt and water into the body and a loss of potassium which results in high blood pressure. Those with Addison’s disease and chronic fatigue syndrome were found to have the opposite problem they have too much BNP in their bodies.

http://www.yourhormones.info/hormones/aldosterone/

https://openheart.bmj.com/content/4/2/e000697

BNP is released during strokes to protect the brain from injury.

http://jaha.ahajournals.org/content/6/12/e007329

Oldly enough high BNP levels increases the risk of high blood pressure in men but not women. It is released when the arteries start hardening, most likely to try and protect the body. Most know by now hardening of the arteries is caused by oxidative stress and inflammation. So high BNP levels would indicate a problem that needs addressed. I do need to research this more because I could not find much information on decreasing or increasing BNP safely.

http://hyper.ahajournals.org/content/hypertensionaha/41/4/978.full.pdf

https://academic.oup.com/cardiovascres/article/51/3/489/369493

Those who are deficient in BNP are more succeptable to fibrosis and lung disease.

https://www.ncbi.nlm.nih.gov/pubmed/16415273

https://www.spandidos-publications.com/10.3892/mmr.2016.5400

BNP is also a contributing factor to the myocarditis caused by endotoxins.

https://ccforum.biomedcentral.com/articles/10.1186/cc2890

Studies have shown that issues in the renal system can effect BNP levels. Most issues with the renal system are caused by toxins or infections, sometimes a lack of certain microbiotia in the gut.

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-5299.2007.06478.x

http://jasn.asnjournals.org/content/23/7/1198.full

BNP increases cortisol and catecholamine levels. There are adaptogenic herbs that reduce cortisol but not sure if they would help with this.

https://www.physiology.org/doi/pdf/10.1152/japplphysiol.00360.2016

Things that reduce BNP also reduces cortisol so I would say there is a feedback loop between the two and reducing cortisol would reduce BNP and vice versa.

Things that raise BNP are excessive alcohol consumption, smoking, stress, sleep deprivation, NSAIDs, oxidative stress, inflammation. So reducing oxidative stress, meditate and do other things to reduce stress, get plenty of sleep, stop smoking if you smoke, consume alcohol in moderation, use natural methods of reducing inflammation instead of NSAIDs shoulld reduce BNP and cortisol.

Calcitonin Gene Related Peptide

Calcitonin Gene Related Peptide is another mechanism the body uses to protect itself. It is released during pain or other stimuli that can indicate harm to the body. Is is found in the nerves throughout the body. It is released during inflammation in nerves and from activation of the capsaicin receptors in the gastrointestinal system. It is a vasodilator so can reduce blood pressure and prevent cardiovascular disease. If too high in the body it can cause high systolic blood pressure. It also causes head aches if levels are too high. Raise levels cause the nerves to become sensitive. Serotonin reduces CGRP. Low estrogen causes a rise in CGRP and is why many experience headaches around the time of their menstruations. Things that contain phytoestrogens may help with this.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620010/

https://www.sciencedirect.com/science/article/pii/B9780128010280001719

I do not recommend trying to increase CGRP because substance P is usually high in those with endotoxemia and it increases the potency of substance P.

https://www.sciencedirect.com/science/article/pii/000689939290812N

It inhibits the inflammation caused by endotoxins.

https://www.ncbi.nlm.nih.gov/pubmed/16317392

CGRP helps protect the lungs from injury.

https://www.ncbi.nlm.nih.gov/pubmed/28560441

https://www.ncbi.nlm.nih.gov/pubmed/12749828

https://www.ncbi.nlm.nih.gov/pubmed/28413467

It may be involved in bone repair.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jor.20406

If levels are too high there are natural inhibitors. Proanthocyanidins increases serrotonin which reduces CGRP. Avoid capsaicin it is a CGRP activator.

http://www.simplywellmigrainerelief.com/2017/02/03/cgrp-antagonistic-plants-natural-migraine-relief/

Mast Cells

Mast cells are one of the bodies first responses to an invader even in parasite invasions. They accomplish this through extracellular trap formation. They also release antimicrobial agents. Some pathogens like tuberculosis have developed strategies to avoid destruction by mast cells. Lyme is another infection that has developed more strategies to evade the immune system the HIV.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643406/

https://www.ncbi.nlm.nih.gov/pubmed/25114115

https://www.ncbi.nlm.nih.gov/pubmed/29892297

http://www.pnas.org/content/115/16/E3788.long

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469150/

Under normal conditions mast cells will reduce inflammation

https://www.ncbi.nlm.nih.gov/pubmed/28471519

When endotoxin levels get high then mast cells start to break down which causes high histamine levels. This results in allergies and sensitivities.

https://www.ncbi.nlm.nih.gov/pubmed/22581748

Because some pathogens can evade the effects of mast cells in removing them it can set off mast cell activation syndrome or mastocytosis. Both disorders are very similar and difficult to tell appart.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112577/

Description of mastocytosis. Symptoms can be skin rashes or lesions, difficulty breathing, swelling under the skin or in the mucous membranes, diarrhea, low blood pressure, bloating, Inhibiting inflammation, cox, and reducing histamines helps resolve this. I have mentioned in the links at the beginning of this article things that help reduce histamines and on another post I did no gut microbiome I mention probiotics that will reduce histamines. The symptoms of Mastocytosis and mast cell activation syndrome are similar and how to resolve it are the same.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002427/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122143/

Because LPS causes leaky gut it can result in mast cell activation , which leads to food intolerance and allergies. This in turn can lead to many metabolic issues.

https://healinghistamine.com/leaky-gut-the-mast-cell-histamine-crohns-disease-connection/

https://chriskresser.com/could-your-histamine-intolerance-really-be-mast-cell-activation-disorder/

Proenkephalin and Kyotorphin

proenkephalin an kyotorphin are neuroactive dipeptides that plays a major role in pain regulation in the brain. They release met-enkephalin which has opioid like effects. Low levels of kyotorphin causes persistent pain. It also reduces inflammation similar to how steroids do.

Has effects of endotoxin induced inflammation similar to how steroids would.

https://pubs.acs.org/doi/10.1021/acschemneuro.7b00007

They are neuroprotective

https://www.ncbi.nlm.nih.gov/pubmed/28127286

Kyotorphin levels have been found to be low in those with alzheimers.

https://www.ncbi.nlm.nih.gov/pubmed/24198785

kyotorphin has antimicrobial properties.

https://www.sciencedirect.com/science/article/pii/S0006291X12005128?via%3Dihub

Oxygen deprivation stimulates the release of kyotorphin.

https://www.ncbi.nlm.nih.gov/pubmed/29635654

Met-enkephalin reduces symptoms of chronic inflammatory diseases.

https://www.ncbi.nlm.nih.gov/pubmed/29261263

https://www.ncbi.nlm.nih.gov/pubmed/28647454

hypothalamus-adrenal-axis regulates met-enkephalin so it is important to reduce inflammation, histamines, and toxins because they can have a negative impact on them. Vaccinations, farm chemicals, fluoride and drugs, especially fluoroquinolone have been shown to disrupt the HPA axis. Stress and lack of sleep also disrupt the HPA axis. Thiamin deficiency can have a negative impact on the HPA axis and glyphosate causes many nutrient deficiencies. Many of us are in very stressful situations we cannot get out of, we must learn to remain calm because it will effect the HPA access. I know it can be difficult but if we don’t win that battle we will lose the long term battle.

https://www.ingentaconnect.com/contentone/isez/fb/2017/00000065/00000004/art00004?crawler=true&mimetype=application/pdf

https://bengreenfieldfitness.com/article/brain-articles/how-to-fix-hpa-axis-dysfunction/

http://ndnr.com/anxietydepressionmental-health/optimizing-the-hpa-axis/

Those who are G6PD deficient or have certain metabolic issues would get ill from the foods that contain thiamine so they may have to supplement thiamine until they have corrected those issues.

https://draxe.com/thiamine-foods/

Melatonin

Melatonin – is one of the bodies most powerful antioxidants. It is produced in the pineal gland. It regulates our sleep wake cycles. It is a powerful anti-inflammatory. It also regulates our blood pressure. It can be found in our food. Foods that contain it are bananas, grapes, rice, grains, plums, olive oil, pineapple, and oranges. I do not believe in taking things orally because often times taking things orally can disrupt the bodies ability to produce the substance so I try my best to stimulate the production or find food sources. Inflammation disrupts the production of melatonin.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666183/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754670/

Those who are G6PD deficient or have certain metabolic issues would get ill from the foods that contain thiamine so they may have to supplement thiamine.

https://draxe.com/thiamine-foods/

Melatonin helps prevent endometriosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015458/

Over consumption of alcohol causes leaky gut, we know leaky gut raises endotoxin levels. This leads to a reduction in metatonin.

https://www.physiology.org/doi/abs/10.1152/ajpgi.00002.2015

We know inflammation, toxins , stress, and many other things cause oxidative stress which cause high hydrogen peroxide levels. Melatonin reduces oxidative stress. Hydrogen peroxide causes severe damage throughout the body including the blood brain barrier which makes the brain succeptable to injury and infection.

https://www.sciencedirect.com/science/article/pii/0891584995001013

Unnatural light especially blue light like what is emitted by computer and cell phone screens disrupts our ability to produce melatonin. Sunlight stimulates melatonin production. Many things have cause magnesium deficiency which is needed to produce melatonin. Over farming has depleted nutrients from the soil, glyphosate and glufonisate chelate minerals from the soil, they are chemicals used in modern day farming.

https://www.institutefornaturalhealing.com/2015/05/5-natural-ways-to-boost-melatonin-production/

http://www.naturallivingideas.com/boost-melatonin/

https://www.sepalika.com/living-well/benefits-of-melatonin/

There are many benefits to getting sunlight in moderation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290997/

Norepinephrine, also known as Noradrenaline.

Norepinephrine – it is an amino acid derivative that functions as a hormone and neurol transmitter. It is produced in the adrenal glands and an area of the brain stem that is responsible for our responses to stress and panic. It functions to mobilize the body to action. It rises when we wake and in the presence of danger or stress. It enhances memory retrieval . Too much norepinenphrine causes restlessness and anxiety. It increases heart rate and triggers the release of glucose. It increases blood flow to the muscles. It reduces blood flow to the gastrointestinal system and inhibits bladder voiding. So it can cause inhibited digestion and difficulty voiding the bladder when levels are high. Norepinephrine prevents low blood pressure. Low levels of norepinephrine have been tied to depression and ADHD. So we can see how we need to reach homeostasis with norepinephrine because it has dramatic effects throughout the body. Metabolic issues can prevent it from being produced or prevent it’s break down. So if we have high or low levels we must address metabolic issues especially phenylketonuria.

https://breakingmuscle.com/fitness/understanding-our-adrenal-system-norepinephrine

Norepinephrine helps protect from sepsis.

https://www.ncbi.nlm.nih.gov/pubmed/25277635

Low norepinephrine has been linked to depression, impaired thinking, physical weakness, chronic fatigue syndrome, and fibromaylgia. High norepinephrine has been linked to increased attention, increased awareness, anxiety, restlessness, paranoia, increased heart rate, hypertension, reduced sensitivity to pain, ADHD, depression and difficulty digesting foods and difficulty urinating. There are ways discussed in this article to reduce or raise levels. Though the effects it has is incorrect in this article. Many sites state these things but when I read the research the effects I mentioned above is what the research has shown. So they may be correct on how to lover or raise levels but many sites are incorrect on the effects of norepinephrine.

Tryptophan and tyrosine are used to produce norepinephrine. I used this when my myocarditis was at it’s worse and I had severe POTS.

http://www.a1b2c3.com/Neurotransmitters-Norepinephrine-001.html

https://universityhealthnews.com/daily/depression/surprising-research-challenges-our-understanding-of-norepinephrine-deficiency/

https://healthyliving.azcentral.com/natural-ways-improve-serotonin-norepinephrine-production-4930.html

Low norepinephrine increases risk of dying from sepsis.

https://journals.lww.com/ajnonline/Fulltext/2017/07000/Norepinephrine_Shortage_Led_to_Increased_Deaths.9.aspx

This is where those with interstitial cystitis would not benefit from this because of the effects it has on blocking the ability to void the bladder.

https://www.openanesthesia.org/norepinephrine_cv_effects/

Endotoxins cause BH4 to upregualte to protect the brain. This can result in high sulfite levels in the body which can cause problems.

https://www.sciencedirect.com/science/article/pii/S0006899318300660?via%3Dihub

Hawthorne leaves and fruit have many healing abilities and have been shown to help with endotoxemia.

https://www.nature.com/articles/aps20167

Reducing Cholesterol, LDL is a symptom not a cause.

Cholesterol Dysregulation/High LDL

This is not medical advice I am sharing what I have learned from me fellow suffers. I am posting this to give others some ideas of things they could research. If you are ill you should see a doctor. Make sure if you are using alternative methods of healing you inform your doctor. I believe before getting treated for any pathogen you should always do a detox protocol first because most damage from being ill is from the endotoxins and exotoxins produced by the pathogens especially when they are dying off. If you have high Low Density Lipid cholesterol levels (LDL) then you most likely have an auto immune disease brought on by Vaccine Injury, Lyme Disease, toxins in the environment, many pathogens can cause Cholesterol Dysregulation, GMOs are known to destroy our guts which causes autoimmune disease and cholesterol dysregulation. Also bad eating habits, to much sugar causes inflammation which can cause oxidative stress which will raise oxLDL levels. Processed foods are high in oxLDL. Cooking increases oxLDL levels in food. Eat raw when possible. Eating processed foods. LDL is oxidized Cholesterol. If you have a lot of oxidative stress , like working too much, stress in our environment, toxins. Many things can cause oxidative stress. This causes the cholesterol to be oxidized much quicker. Gut problems can also cause high LDL levels. If we are having problems with our digestive system then our bile production will decline.

Endothelial Cells help in bile production, if they are not healthy then our production of bile declines decreasing our ability to remove LDL from our bodies. There is also a layer called Tight Junction Protein layer if it is damaged particles can get into our blood stream causing a histamine response which can cause inflammation throughout the body which can result in many problems, autoimmune disease, interstitial cystitis the list goes on and on the inflammation can interfere with many metabolic functions which could cause a rise in LDL levels. It isn’t much how much cholesterol we take in but the type and our environment that affects our LDL levels. Liver and Bladder problems brought on by all the above can cause Cholesterol Dysregulation.

If the Nrf2 pathways become blocked it will cause high LDL levels. Especially if the Pentose Phosphate Pathway becomes hindered or blocked. Another thing that can cause Cholesterol Dysregulation and this one surprised me but is also affected by autoimmune disease so it shouldn’t have is the Lymph Nodes. If they are plugged or infected they cannot help keep the blood cleaned out.
Get plenty of good cholesterol from sources such as coconut oil or avocados. Cholesterol is an antioxidant. If oxLDL is high it is a sign of excess oxidative stress or inflammation and the body is trying to protect itself. High oxLDL is a symptom not the cause. Lowering cholesterol will effect the brain and muscles negatively because they cannot function without it and the brain can suffer permanent damage if it does not get enough cholesterol. When I get a chance I will add the supporting links for these statements. .

Now That We Know The Problem Let’s Try To Solve it. The first thing I would do is work on reducing inflammation and lowering histamines. If you do have gut problems that would be the place to start. Next I would work on the methylation pathways. I covered some of that in my note on detoxing. I covered the CBS pathway also in that note. If it is blocked you will have trouble getting the Nrf2 ( nuclear factor-erythroid 2-related factor 2) pathways opened up because anything that raises gluthione production with cause you to feel ill. Another problem is antioxidants will actually cause you cancer if you take them too often or if the Nrf2 pathways are blocked. Don’t over do it with antioxidants and make sure you work on getting your Nrf2 pathways opened. Now some things that help open the Nrf2 pathway can also stimulate it so you do not want to over do it. When you start feeling better back of a bit. It is a good idea to space your supplements out anyways. Some things that will open the Nrf2 pathways are Oleanic Acid found in Savory and Olive Oil. Taxifolin (dihydroquerciten) also helps open them, it is a super antioxidant and one of the few that doesn’t need the Nrf2 to function. It is like Querciten on steroid. Chaga Mushrooms have Super Oxide Dismutase which helps the body in many areas. It is the only source I know of that the SOD is readily absorbed by the body, all the other sources have a low absorption rate. Do not take too much, raising SOD too high can raise reactive oxygen species which would have the opposite effect.

Cruciferous vegetables are high in sulforapanes which help open and stimulate the Nrf2. Make sure you do not have sulfation issue which can be caused by vaccine inujury , toxins like mercury and glyphosate. This will raise your sulfite levels which will cause high ammonia levels and high reactive oxygen species which causes damage from the oxy radicals being produced.

If NADP (Nicotinamide Adenine Dinucleotide Phosphate gets too high then the Pentose Phosphate Pathway could be inhibited. Low doses of Niacin along with Zinc, Vitamin C(too much vitamin C can destroy red blood cells, also man made vitamin C cause oxalates), NAD+, Vitamin D3, Curcumin, Querciten, Resveratol, Another thing that happens is if your methylation pathways aren’t working right or you have and infection your ammonia and hydrogen peroxide levels can go up and it will cause Cholesterol to oxidize. You would think that taking an antioxidant would be the solution but as stated earlier make sure you detox and get your methylation pathways corrected or that can do more harm then good. Now if you worked on your gut and methylation pathways. Then I believe we should work on the liver next. From my research I am lead to believe that oils high in monosatuarated fats produce less LDL when they are subject to heat. Some oil that are supposed to be good for cooking with high heat are. Hazel Nut Oil, Macadamia Nut Oil, Peanut Oil, Safflower Oil, Sesame Seed Oil, and Rice Bran Oil. Sun Flower is supposed to be one of the best but it scares me because Sunflower is used to pull toxins out of the soil. Canola is supposed to be good but most canola is GMO now. We need to be careful getting too many Omega-6, studies have shown if levels get too high we can develop mental issues even become violent, they can cause endothelial dysfunction which can cause high LDL levels, and cause inflammation.

So now if you worked on the above mentioned problems we are ready to move on to other issues we may have. Avoid Trans-Fats, unsaturated and saturated fats are bad fats and cause oxLDLs to go up. Reduce intake of Corn, Wheat, and processed sugar. They cause inflammation which for various reasons can cause oxLDL levels to go up. Termina Chebula – has many nutrients that help with methylation. Has many antioxidants, has also been shown to fight gum disease. Tyrosine – if you are not methylating properly your body cannot produce it. It is used by your body to build neuro transmitters and various proteins. Good sources are nuts, avocados, bananas, dairy products, beans and seeds. Ginkgo Biloba – improves the bodies use of oxygen but use in moderation, if used too long or in high doses it can damage the liver. Ginkgo Biloba with Raynaulds sysndrome and depression. P5P methylcolbamin molybdenum and manganese 3 times a week.  Those should help get the body methylating. When the methylation pathways open the body will start detoxing so you should continue the detox protocols the whole time. This could cause the bladder to become irritated again until the toxin levels are down. Those with certain methylation issues need to research before taking those.

The liver Of course drink good clean Chlorine free water. Chlorine is very toxic to the body and very difficult to remove from the body. Do not use flouride it is pretty much the same thing., If you are having problems with ammonia levels still I would suggest taking bromelain and betaine. Also Bacopa is supposed to helps. Papain is supposed to reduce symptoms of fatty liver. Omega-3 oils also help reduce fatty liver symptoms, I alternate the types of Omega 3s I use because each has it’s own benefits. Inositol Hexaphospate (IP6) is supposed to help clean the renal system out. Rosmarinic Acid, Ginger, Ashwangha, and Boswellia are all supposed to help with lipid peroxidation using these for too long or too much can have side effects. If the Nrf2 pathway is working antioxidants like Pycgenol, Lycopene, Allicin etc help lower lipid peroxidation.

CoQ10 is involved in the processes for producing energy for the cells. I use Ubiuinol it is the unoxidized form of CoQ10. Some things that can improve bile flow are Artichoke , Danshen, Prenylated Chalcone, Yarrow Root, Fennel Seed, Dandelion, Trolox, and Carom Seed have been shown to stimulate bile flow. Hesperetin has been shown to be powerful against lipid peroxidation. Aegle Marmelos is know to inhibit lipid peroxidation. Pinelba has been shown to protect the gut and inhibit lipid peroxidation. Silicon Dioxide, Magnesium, Iron, all help to produce bile, they need glycine and taurine to be bile.

Astanxanthin is another potent antioxidant. It reduces peroxide levels, and can cross the blood brain barrier to reduce swelling and provide the brain with energy. Catalase and Chloine also help to reduce lipid peroxidation. If you are low in choline you may get indigestion after consuming any fats. Golden Rod, Japanese Honeysuckle (most other honeysuckles are toxic) have been known to help clean the renal system out.

Lymph Nodes There are many things that can cause the lymph nodes to become plug. Not enough exercise , bad eating habits, environmental toxins, stress, not enough sleep, pathogens. Mold infections are another culprit. Vaccine and GMO damage the list could go on and on. If you read my not on detoxing then you should be half way to getting the Lymph Nodes cleaned out. There are special exercises and massage techniques that can be used to help clear the lymph nodes out. Also brushing the skin to ex-foliate also helps to clean the lymph glans out. Herbs That May help and Supplements for the Renal System.

Vitamin A -allows for proper gene activation within the lymph glands which helps the body develop proper immunity. Sources are orange colored fruits and vegetables, Kale and fish

L-Carnitine – required to transport fatty acids to mitochondria, protects and heals nerves. Protects and heals nerves. Found in meat and milk products, also found in asparagus. Also helps remove toxic compounds generated in cells.

Threonine – Helps prevent fatty liver, helps maintain proper protein balance in the body. Helps break down fats. Most vegetarians are low in this.

Pectin – shown to break biofilms, lowers bad cholesterol levels. Avena (Oat Straw) Helps balance our electrolytes. Has many nutrients needed for healing and proper functioning of the lymphatic system, helps improve cardiovascular health. Also has relaxant qualities. Most say it doesn’t affect them but it knocks me out.

Joe Pye – has been shown to fight renal infection. Should not be taken for extended periods of time because it is a sodium channel blocker.

Buchu – (Agathosma Betulina) fights urinary tract infections reduces hangover symptoms.

Silver Weed (Potentilla Anserina) The leaves have antiviral properties, and contains more flavonoids then green tea.

Aerva Lanata – has diuretic, anti-inflammatory, antispasmodic, antiparasitic, antimicrobial, hepa-protective and anti-asthmotic properties.

Eupatorium Perfoliatum – also known as Boneset (should not be taken for too long has alkaloids that can build up in the body) and Feverfew has been shown to be affective against the common cold and the flu. Aslo affective at treating cytokine dysregulation. Has been shown to be very affective against the plasmodian parasite.

mullein (Verbascum Thapsus) has antibacterial and expectorant properties. Has also been shown to fight mycobacteria. Is a natural anti-inflammatory. Helps ease menstrual and stomach cramps. Has been shown to help with interstitial cystitis.

Ajuga Decumbens improves liver and kidney function, helps correct hypoglycemia.

Hovenia Dulcis – protects the renal system, reduces oxidative stress. Helps to protect the brain. RDA 1400 to 2500 mg. Cysteamine – helps remove blockages in the renal system.

Acanthus Ilicifolius – increases production of osteoblast which are necessary for bone growth and health. Has been shown to help gastric ulcers heal. Has strong antibacterial and antifungal properties. Chlorophyll – helps restore blood health, lowers our risk of cancer, helps to remove heavy metals from the body and other toxins. Has been shown to fight Candida and protect the good bacteria in the gut. Sources are green produce, spirullina. Many including me had reactions to spirulina so I use liquid chlorophyll (to not use more then 3 times a week it can raise copper levels).

Horse Gram (Dilichos Biflorus) Help dissolve kidney stones, also kills many pathogens. The seeds are used to make tincture.

Varuma – Bark, root and leaves are used. Good at breaking up kidney stones, also hinders their formation. Has anti-inflammatory affects. The root is a laxative. Varuma also helps with flatulence and gas pains. !!May cause blistering if used on the skin!!

Oregano Oil – contains Carvacrol which protects the liver, has been shown to inhibit cancer growth. Works as a good nontoxic disinfectant. Has been shown to be as affective as chlorine. It kills Candida and helps protect the cardiovascular system from LDL and reduces inflammation.

Moringa Oleifera – has antibacterial properties. Has been shown to stabilize blood pressure. Helps reverse some liver damage. Contains Quercetin. The seeds have been shown to improve asthma symptoms.

Ajuga Decumbens improves liver and kidney function, helps correct hypoglycemia.
Cleavers helps clean the lymphatic system out.
Lemmongrass – Lowers oxLDL, helps get toxins out of the body and lowers uric acid levels. Has been shown to be affective against cancer. The essential oil has antimicrobial properties and has been shown to be affective against H-Pylori. Has also been shown to aid colitis. Calms muscles and nerves Helps relive pain including headaches. Has been shown to reduce the occurrence of convulsions and helps repair the immune system.!!Be careful some have had an allergic reaction to this.!!

Butyrate producing gut bacteria help reduce oxidize lipid levels.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0117851

Copper deficiency can cause oxLDL

https://wholehealthsource.blogspot.com/2010/04/copper-and-cardiovascular-disease.html

High Homocysteine can cause high LDL

https://www.sciencedirect.com/science/article/pii/S0014579309001860

Olive oil improves lipid metabolism.

https://www.ncbi.nlm.nih.gov/pubmed/12358487

Lipid peroxidation and HDL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656652/

Pantethine reduce oxLDL.

http://www.ppt-health.com/artery-plaque/pantethine-and-arterial-plaque-removal/

https://universityhealthnews.com/daily/heart-health/5-powerful-pantethine-benefits/

FXR is involved in cholesterol metabolism and it’s function becomes diminished with age.

https://www.journal-of-hepatology.eu/article/S0168-8278(13)00867-2/fulltext

High TMAO levels cause heart disease. I posted on how to reduce TMAO in my gut bacteria post.

Vitamin B6 deficiency can lead to heart disease.

https://www.sciencedirect.com/science/article/pii/S0899900706003224

https://academic.oup.com/ajcn/article/81/3/725/4649116

https://paulaowens.com/vitamin-b6-deficiency/

Causes of B12 issues.

https://www.b12-vitamin.com/blood-levels/

Calcium-D-glucuronidase reduces risk of cancer.

https://www.tandfonline.com/doi/abs/10.3109/09537104.2010.512210?journalCode=iplt20

https://www.hindawi.com/journals/ecam/2015/871832/

Alpha R-lipoic Acid helps with oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976966/

Liver disease and Pemt issues can cause oxLDL. I posted on fatty liver disease.

Hormones and cholesterol.

Cholesterols function in bile secretion. Issues with the liver X receptor can cause issues with cholesterol metabolism.

http://www.jbc.org/content/278/18/15565.long

https://www.ncbi.nlm.nih.gov/pubmed/29523554

Olive Oil help resolve liver X receptor issues. But inhibits glucuronidation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521785/

Butyrate found in butter and ghee also help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111843/

High estrogen inhibits sulfation. Increasing UDP-glucuronosyltransferases will reduce estrogen levels.

http://www.jbc.org/content/275/46/36164.full.pdf

http://dmd.aspetjournals.org/content/30/5/564

DHA, oleic acid, and linoleic acid inhibit those enzymes.

https://www.nature.com/articles/srep02903