Why correcting inhibited bile or constipation is not always so simple.

I am asked pretty often how to correct inhibited bile flow. This is not and easy question to answer and there are many things that can cause it. I will show you how complex of a question that is. There are a huge number of things that can effect bile production. It is probably one of the most difficult things to correct because there is a lot of questions that need answered to know what is causing to occur and it is different in each individual. If bile is inhibited then gall bladder issues will pretty much be a given. A person with issues in bile flow will have trouble digesting food it will sit like a brick in their stomach and ferment. If they have motility issues the bile they do produce will enter the stomach so they would still appear to be deficient in bile. The way to break the cycle is to correct what is causing it but it is not simple figuring out why. So here is the list of things that can cause inhibited bile flow or inhibited motility (constipation). This is by no means a complete list. This is also why there are many question that need answered when constipation is chronic.

High estrogen levels.

High copper levels

Low serotonin levels.

High noadrenaline levels or high adrenal hormone levels also connected to copper.

Low substance P levels.

Inflammation

candida overgrowth or gut dysbiosis

low cholesterol or issues with cholesterol metabolism

inhibited vitamin D receptor or low vitamin D levels.

Inhibited retinoid x receptor

lactase deficiency which cause lactose intolerance and is a sigh of a deficiency in saccharmyces boulardii.

Low amylase

Poor mucous membrane health

lipase deficiency

excess pancreatic polypeptide

pancreatic elastase deficiency

hypothalamus injury or issues.

High insulin levels

Nutrient deficiency or issues with protein metabolism especially taurine

electrolyte deficiencies

Low cysteine levels

low vasoactive peptide levels

high glucagon levels

high secretin levels

high somatastatin levels

Gastin hormone from low histamines

low bombesin levels

high cholecystolinin levels

infection

leaky gut

issues with sulfation or high sulfite levels

bile duct obstruction

T cell imbalance

high oxalate levels

High Lysolecithin found in processed foods.

High COX-2 levels

Not getting enough medium chain fatty acids.

High sulfur digesting or methane producing bacteria levels , dysbiosis

Decreased COMT activity

High folic acid levels which is not the same as folate

Low betaine homocysteine S-mthyltransferase levels which leads to hypothyroidism

choline deficiency or issues with choline metabolism

Deficiency in Akkermansia Muciniphila

Issues with lipid metabolism

Issues with the Kreb’s cycle also known as the citric acid cycle.

Low HNF4a levels

High B-hydroxybutyrate levels caused by low oxaloacetate levels.

Hydrolase synthase deficiency

alkaline phosphatase deficiency which inhibits bile and decreases good gut bacteria levels in the gut increasing the bacteria that inhibit bile.

Inhibited FXR receptor

decreased motilin

Inhibited ABCB4

Inhibited CYP7a1 enzymes

pyruvate carboxylase deficiency

Digestion probably more then you wanted to know. Enzymes and bile and stuff.

This is not medical advice I am posting this for informational and educational purposes.

This is not done I have a lot to add to it but I am kind of burned out. I will finis it later after I take a break.

Gastrointestinal motility and digestive enzymes.

This is mostly on bile but I wanted to cover the other areas of digestion before I covered bile.

Inhibited bile causes constipation. Frequent constipation increases Bilophila Wadsworthia which causes appendicitis. Trans-fats and saturated fats should be avoided when bile is inhibited or when constipated because they increase the growth of Bilophila Wadsworthia. Trans-fats should be avoided anyways they are very bad for our health.

Most know how digestion works but we need a refresher. When we chew our food it is mixed with saliva which has some digestive enzymes in it. When we swallow it is propelled down the esophogus where it is mixed with enzymes and gastric acid. The end result is called chyme. The chyme is pushed into the small intestine (duodenum). Many will ask me how to increase bile production but doing so could cause more harm then good. The problem causing the inhibited bile flow needs to be addressed. For example a dam can only hold so much water. If there is more water then the dam can hold it will flood over the top. Adding more water to the dam adds to the problems and could break the dam. When there is a blockage causing bile flow to be inhibited then increasing bile would be like adding water to a dam that is already overflowing. Most health issues mentioned in this article I have discussed elsewhere on my blog.

Peristalsis is the movement of food through the digestive system. It is the cause of the gurgling sound you hear when you are hungry or digesting food. Usually you cannot hear it. I do not know why but I and my friends experienced this. As we healed our digestive system you could feel the food moving and the sounds of digestions were very loud. As we healed they became quieter and quieter.

In the small intestine the food is combined with bile and pancreatic enzymes to break it down further and for nutrient absorption. The smooth muscle in the intestines are ring shaped and alternate between contracting and relaxing. This causes the food to move slow enough through the digestive tract for it to be broke down and for the nutrients to be absorbed. The neurons are stimulated by acetylcholine, and substance P to get them to contract. Nitric oxide, vasoactive peptide and ATP relax the muscles. This causes a motion that moves the food through the digestive tract and occurs the most in the small intestine. There are health issues that can cause a high acetylcholine and high substance P levels. High noradrenaline reduces substance P which can interfere with intestinal motility and can lead to constipation. High estrogen levels can inhibit substance P. High substance P levels can cause inflammation and lead to inflammatory bowel disease. There are health issues that can cause low acetylcholine and low serotonin levels. This also will cause a loss of motility leading to constipation. An imbalance in our immune system can cause bile flow to be inhibited. Estrogen inhibits bile flow and progesterone pormotes bile flow. This causes the liver and thyroids to become sluggish. This can also lead to interstitial cystitis. All the above mentioned things can inhibit receptors and throw hormones out of balance. If not addressed it will become chronic and start a cycle that is difficult to break and can take months to years to heal from.

https://www.selfhacked.com/blog/substance-p-roles/

If the gurgling in the gut is excessive and there is cramping, abdominal pain, and possibly nausea and vomiting it could indicate slow gut motility or a blockage. This can be caused by intestinal damage, hormone imbalance, inflammation in the intestines, dysbiosis, candida overgrowth, a deficiency in certain gut microbiota, slow or inhibited bile. This causes gas, bloating, and distention (inflammation in the gut). If we have a T cell imbalance or high B cell levels this can also cause it. If not addressed it can result in a decline of intestinal health our the health of the body. High histamines can cause inflammation that can cause blockage. We do not want to inhibit them because histamines are needed to stimulate gastric acid. It is best to work on reducing them.

If the digestive system is injured and we do not give it the things needed for it to heal then it loses the ability to sense nutrients and food that has entered it so it cannot respond to them. The longer it goes like this the worse it gets and the longer it will take to heal.

Bile acid is needed for the healthy brown fat to be produced. Bile acid is synthesized form cholesterol. Excess oxidative stress or inflammation in the liver can cause low cholesterol levels or can inhibit it’s production which would prevent the bodies ability to produce bile properly. This can also cause bile to become inhibited. When this happens bile production is reduced and it becomes thick. Phosphatydylcholine is needed to store bile in the gallbladder. I have found most who have problems with choline metabolism have benefited from sunflower seed oil. Excess oxidative stress can cause methionine and choline to become depleted. This inhibits the bodies ability to produce bile.

Enzymes.

If you are deficient in certain enzymes often times there are plants you can consume that will helps digest foods that require those enzymes.

Lactase- (B-Galactosidase)- deficiency causes lactose intolerance. It breaks down Lactose down to glucose and galactose. Damage in the gut can cause it to not be reabsorbed. If this happens the gut microbiome will break it down causing gas and bloating. Those who are lactose intolerance will usually also be intolerant of FODMAPS until they get their gut healed enough to correct the malabsorption issues. Those who have malabsorption issues may benefit from taking Lactase when consuming dairy products. Saccharmyces Boulardii has been found to increase enzyme function in those with Lactose and FODMAP intolerance. If a person is lactose intolerant if they avoid dairy products while supplementing galactooligosaccaride for about a month, it has been found to increase Lactose metabolizing bacteria which prevents the bloating and ill effects of lactose. Also slowly introducing dairy into the diet a little at a time can increase the gut microbes that produce lactase. That would prevent a reaction to lactose also.

Alpha-galactosidase- helps break down digested fats and saccharides a deficiency causes lysosomal storage diseases. If defficient in Alpha-Galactosidase when eating fiber and high sulfur foods a person will develop gas and bloating. Those who have a deficiency in Alpha-galcatosidase will be intolerant to complex carbohydrates and may be intolerant to gluten. Beans will be a problem for a person lacking this. Infection can cause A-gal to be inhibited from the LPS produced. Inducing autophagy can testore A-gal. Tick born illness can cause autoimmune disease that can cause the body to make antibodies against a-gal. Balancing the immune system is very important. If not addressed it can lead to a sensitivity to meat.

Things that help with lysosomal storage disease should help with this. https://iamajuicer.wordpress.com/2018/08/21/things-that-may-help-with-lysosomals-storage-disease/

Sucrase- secreted in the small intestine. Catalyzes sucrose , fructose, and maltose. A deficiency will cause lactose intolerance, gas , bloating and diarrhea when things containing sucrose are consumed. Inflammation can cause it’s excretion into the small intestine to be inhibited. Sucrase is also known as invertase. Thyroid hormones and corticosterone stimulate sucrase and maltase. Inflammation and intestinal damage will decrease it’s secretion. High CD8 T cell levels inhibit Sucrase. I have posted on balancing T cells.

Amylases-work with other enzymes to break down polysaccharides. It is the major form of amylase found in humans and breaks down starch to maltose and dextran. It prevents bacteria from producing biofilms by breaking them down. It is secreted in saliva and from the pancreas.

endopeptidase (enterokinase) that breaks down proteins into smaller peptides (it is a protease) It is produced in the stomach and is one of the main digestive enzymes. It transforms trypsinogn into trypsin. procarboxypeptidase into the active enzyme carboxypeptidase which is involved in the maturation of proteins produced. Carboxypeptidase is also involved in enzyme and hormone production throughtout the body. It is produced in the mucus membrane showing the importance of restoring the health of the mucous membrane. This can result in protein and enzyme deficiencies in the body.

Trypsinogen- is the precursor form of trypsin it is found in pancreatic juice that is released in the small intestine. Trypsinogen is activated by the protease enteropeptidase which is produce by the mucus of the duodenum. Trypsin breaks down proteins to ammino acids.

Chymotrypsinogen- precursor for chymotrypsin. It is activated by trypsin.

Pancreatic Lipase- It is secreted into the small intestine in it’s completed form. But it only becomes effective in the presence of colipase which is a co-enzyme.

Phospholipase-converts lipids(fats) to phospholipids.

Lipase-breaks down triglycerides to fatty acids and glycerol. Deficiency causes a lack of fats needed by the body and fats in stools. Lipase also protect the body from parasites and pathogens. If deficienct a person will suffer from malabsorption. There are microbe derived lipases that have been shown to be effective for Lipase deficiency.

Na+ Taurocholate Cotransporting Polypeptide (NTCP) is used by the liver to extract BA returning to the lever through the portal vein. Should not be stimulated in those with cholestasis it can damage the liver. A deficiency causes muscle weakness. If it is inhbited bile salts can build up in the liver resulting in liver damage. This also results in an increase in blood levels of bile acids.

Pancreatic Polypeptide self-regulates pancreatic secretion activities. It’s secretion is increased from protein consumption, fasting, exercise, and is decreased by glucose and somatostatin. It can inhibit gallblader contractions and pancreatic exocrine secretion.

Pancreatic Elastase – help finish breaking down foods. If there is excess oxidative stress , inflammation or immune imbalance that effects the pancreas it can inhibit pancreatic enzyme secretion. They usually test for this enzyme in stool to see if the pancreas is functioning properly.

Digestive hormones.

Most of these hormones are effected by our brain especially the hypothalamus. If we have endotonins, heavy metals , glyphosate or other toxins that effect the brain then our digestion will be effected which further effects our brains. The hormone imbalance causes mental issues. They can be corrected if you address what is causing the imbalance. Many will take medications, which only treat the symptoms. Most medications for those types of things effect digestive hormones adding to the problem. Then when a person starts correcting the problem their mental issues become worse because of the drugs they are taking and the body starting to function correctly will swing hormones in the other direction. When the digestive system is damaged our cells that produce hormones become less numerous. We must try and protect the so healing can begin. Also nerve cells become less numerous which makes our bodies digestive responses to be much lower. Regular and electric acupuncture have been shown to help restore normal hormone levels. Bile acid also regulates lipid and glucose homeostasis. If bile acid become inhibited Thyroxine (T4) levels increase and Tiiodothyronine (T3). Low T3 levels inhibits oxidation which is needed to use lipids and cholesterol in the body. This will cause low LDL levels and high HDL level. Low T3 levels inhibits the bodies ability to synthesize proteins. Insulin loses it’s ability to inhibit glucogenesis. This cause glycolysis to be inhibited. This also effects the heart and can cause heart palpitations. High T4 levels can cause a decrease in serotonin.

Ampulla of Vater blocakge– inflammation, oxalates, toxins, infection or damage in the body can lead to pancreatic enzymes building up causing the pancreas to digest itself.

If you have blockage inhibiting enzyme secretion I would not advice stimulating the secretion until the health problems causing the blockage have been addressed.

When we have metabolic issues, inflammation or any other of the health issues I have describe these enzymes can be effected. Especially if we have damage to our digestive system.

Serotonin – (5-HT) regulates gut motility. It is produced in the mucosa of the gut. It increases peristalsis (movement of food through digestive tract). It has been found to be low in those with inflammatory bowel diseases. A deficiency can cause gastroparisis and bile reflux. It also stimulates adenylyl cyclase which is involved in cell signaling throughout the body. Most drug agonist of the 5-HT receptors damage the liver and heart. Acupunture stimulates serotonin. There are some disorders which inhibits 5-HT from exiting the cells. This causes a build up in the cells and a person will be senstitive to 5-HT but would still have symptoms of 5-HT deficiency.

Motilin – triggered by fasting, and fatty foods. Controls peristalsis by stimulating smooth muscle contraction and relaxation to coordinate the movement of food through the digestive tract. The antibiotic erthromycin stimulates motilin. Motilin had been found to be low in those with inflammatory bowel diseases. Acupuncture increases motilin. Motilins effects are influenced by PH. Low PH motilin inhibits gastric motility at higher PH it stimulates gastrointestinal motility. Food intake slows the production of motilin. Insulin also inhibits the secretion of motilin.

Reflux can be cause by bile issues in two ways. If there is a blockage a person could experience bile acid reflux. If there is insufficient bile production the the acid from the chyme does not get neutralized by the bile and will cause acid reflux. L-taurine and betaine also known as TMG helps with bile production. Cysteine is also needed and taking NAC (N-acetylcysteine) about three times a week has been found to help. If it is taken more then that the benefits are lost.

Gastric Inhibitory Peptide – triggered by glucose and fatty foods. Decreases gastric emptying and stimulates the release of insulin. It promotes fat storage.

Vasoactive Peptide – increases blood flow to the gut, supplies eleyctrolytes to pancreatic enzymes and bile.

Guanylin – causes secretion of chloride , decreases absorption of water from the gut. It prevents the sodium levels from the body from getting too high by inhibiting salt absorption and by stimulating the secretion of bicarbonate and chloride.

Glucagon – glucagon supresses CYP7A1 which reduces bile production. This can lead to insulin resistance and glucose intolerance. Glucagon prevents blood sugar levels from getting too low. It is involved in gluconeogenesis which produces glucose form proteins.Glucagon also breaks down fat stores in the blood stream. Excess glucagon leads to diabetes and thrombosis.

Glucagon Like Protein-1 (GLP-1) Whey protein increases GLP-1, glucose also stimulates GLP-1. Slows down digestion. It increases the size and health of pancreatic B cells. Stimulates brain repair. It’s release is stimulated by TGR-5. GLP-1 is involved in appetite suppression and glucose homeostasis. Low levels causes glucose deficiency. Carbohydrates and elevated blood levels of proteins helps stimulate glucagon . If we are deficient in glucagon glycogen can build up in the livers. It brings down glycogen in the liver by breaking it down to produce glucose. Somatostatin inhibits glucagon production. Excess glucagon cause weight loss and deficiency causes weight gain. Fasting stimulates glucagon production.

Secretin- helps regulate water homeostasis in the body, helps regulate the PH of the small intestine by gastric acid. Secretin inhibits gastic acid production and stimulates the production of bicarbonate. Secretin also stimulates bile production. It is produced mainly in the mucosa of the small intestine and jejunum. It is release from the low ph caused by chyme entering the small intestine.

Secretin deficiency causes a loss of neural progenitor cells. Progenitor cells are similar to stem cells. Since secretin increases neural progenitor cells it helps with autism, motor coordination and improves memory. Secretin helps with asthma by acting as a bronchorelaxer. Secretin reduces symptoms of pancreatitits.

In order to function properly levels of cholecystokinin and insulin need to be normal. If they are dis-regulated it effects secretin levels. It also stimulates polyamines in the pancrease which is needed for cell growth. Polyamines also regulate ion channels including the NMDA recemptors, AMPA receptors and potassium channels. Excess polyamines can cause the blood brain barrier to become more porous. Showing the importance of secretin homeostasis. When H Pylori in in it’s pathogenic form it will cause a secretin deficiency. Secretin promotes the production of mucus. A decrease in secretin decreases the function of angiotensin 2. Secretin increases thirst. Secretin increases the feel good hormone oxytocin.

Now the bad if a person has bile blockage like cholestasis it can cause liver damage. I discuss things that can help with that at the end of this blog post. Secretin causes Zollinger-Ellison syndrome to worsen.

High levels of somatostatin inhibits secretin.

Cholecystokinin- stimulates the release of digestive enzymes and bile from the pancrease and bladder. Whey protein stimulates CCK. Fat intake also stimulates CCK. A deficiency in CCK causes malabsorption and can lead to Type 1 diabetes. Damage to the mucus membrane can cause a deficiency. This can also be caused by autoimmunity. This is where a dilemma occurs. High levels of bacteroidetes or high levels of methane producing bacteria can inhibit CCK. Protein stimulates CCK. I believe working on bile blockage and then once that is corrected increasing bile flow first to reduce the bacteroidetes levels and methane producing bacteria then adding protein into the diet once they are reduced would most likely correct the problem along with restoring the health of the mucus membrane.

Intrinsic Factor-important in the absorption of vitamin B12. Often times B12 deficiency is caused by a lack of the microbiota that produce B12 but is mistakenly attributed to and intrinsic factor deficiency.

Haptocorin-binds to B12 in our food protecting it from our gastric acid so it can survive the stomach. It is found in our saliva. This shows the importance of making sure we chew our food very well.

Gastrin- hormone that stimulates gastric acid secretion. It is released from the pariental cells in the stomach. It also aids in gastric motility. Elevated gastrin can cause hypergastrinaemia. Low levels can cause hypergstrinaemia. Infection can effect gastrin levels and so can histamines. Histamines are needed for Gastrin stimulation if histamine levels are too low the we will not produce enough stomach acid. If they are too high then we can get acid reflux. If someone is not producing enough acid then they most likely have low histamines and would benefit from fermented foods and aged meats which are high histamine.

Gastric inhibitory polypeptide- an inhibiting hormone of the secretin family. It stimulates insulin secretions based on how much glucose is present. It stimulates glucagon secretion and fat accumulation. It is found in intestinal mucus, small intestine, and jejunum of the gastrointestinal tract. Has many other functions throughout the body including bone growth.

Vasoactive intestinal peptide- serves functions throughout the body but relaxes smooth muscles in the trachea, gall bladder and stomach.

Bombesin- stimulates gastrin release from the pancrease. It also stimulates adrenal and pituitary hormones. It increases the thickness of the mucus membrane. It modulates the neural firing rate in the intestines so is involved with gastrointestinal motility.

Somatostatin reduces histamines which will reduce the gastric acid stimulating effects of histamine. In those with inflammatory bowel issues somatostatin in usually very high. Acupuncture has been shown to reduce somatostatin. Most lactobacillus bacteria will reduce somatostatin. Somatostatin prevents the over production of certain hormones in the body. If there is excess somatistatin it will inhibit hormones especially insulin. Somatostatin inhibits glucose and fat absorption. It inhibits insulin and glucagon in the liver. It stimulates muscle contractions in the intestines speedingup transit times. Protein stimulates somatostatin.

Cholecystokinin, glucagon-like-peptide, gastrin-releasing peptide stimulate somatostatin.

Substance P, insulin, pancreatic polypeptide, and opioids inhibit somatostatin.

Excess somatostatin inhibits bone growth, disrupts sleep, and increases dopamine, norepinephrin and epinephrine.

High levels somatostatin will cause high thyroid hormone levels because it inhibits thyroid stimulating hormone which senses hormone levels and shuts them down if they get too high. This causes weight loss no matter how much a person consumes , flushing or hot flashes, and heart palpitations.

Insulin- breaks down blood glucose. Excess insulin can lead to cancer and many other health problems. Glycoproteins increase insulin. Whey protein increases insulin and reduces blood glucose levels. This is one that confuses me and makes me believe those with inflammatory bile have blockages. Many with inflammatory bowel have high insulin levels which stimulates CYP7A1 which should increase bile production and still they have low bile flow and often times CYP7A1 levels are low. It may be that inflammation is inhibiting the receptor.

Ghrelin-triggered during hunger or calorie restriction. Stimulates appetite. Whey proteins increases Ghrelin. Ghrelin is involved with gastric emptying.

Deacyl-ghrelin – DAG decreases gastric emptying, induces postprandial fullness and improves insulin sensitivity.

Peptide YY- secreted after eating it cancels out the effects of ghrelin.

Pheonixin – expressed in the hypothalamus, it stimulates appetite.

Peptide YY- produced in the gut where short chain fatty acids are produced. Proprionate and butyrate increase expression of Peptide YY. It reduces appetite. It is stimulated from the consumption of fiber from fruits and vegetagles. It also reduces pancreatic secretion.

Leptin – regulates body fat.

http://www.jnmjournal.org/journal/view.html?uid=1395&vmd=Full&

Bile Acids

Bile stimulates the secretion of electrolytes and water into the intestines which stimulates digestion. Biles acid stimulates the release of 5-HT. Those with inflammatory bowel diseases have been found to have high levels of bile acids Taurocholic Lithocholic Acid, Taurocholic acid and Taurocholic Deoxycholate.

Bile acid promotes liver regeneration by activiating BA recperors Farnesoid X receptor and G-Protein-coupled BA receptor1 (GPBAR1 or TGR5) . This shows the importance of bile acid homeostasis. Proper bile acid production is very important for maintaining a balanced gut microbiome.

Inhibited bile can cause gall stones and lead to liver and kidney disease.

There are many things that can inhibit bile production. Inflammation, toxins, metabolic issues, especially inhibited receptors involved with bile production. Infections can cause bile to become inhibited and so can the endotoxins they produce. If we develop leaky gut the LPS (lipopolysaccharide) which is produced by pathogens and our commensals can enter the blood stream. Our microbiome uses LPS to communicate with our bodies but when it gets into the blood stream it causes the same problems a pathogen would. We also have commensal microbes that break down LPS antibiotics and farm chemicals especially glyphosate and glufonisate can kill our gut microbiome. They modulate most organs in our bodies including our brains. They even modulate some of our genes. Without them we will not have an immune system and we cannot restore the body to homeostasis. Metabolic issues can cause acidosis or alkalosis which will also interfere with the propper function of our organs and causes a lot of damage which progresses and becomes more severe if the problems causing them are not addressed. Infection can also change the PH of the body. There is a myth that alkalizing the body will make us healthier. This is not true but it promotes things that are usually commensal like Candida and H Pylori to turn pathogenic. If a person has candida and H Pylori problems they most likely have high ammonia levels. This causes BH4 to become depleted increasing the ammonia levels even more. If not addressed they will start having problems eating high protein foods and high sulfur foods. Another thing that can cause blockage that effects bile flow is oxalates. They can be produced endogenously or we can get them exogenously. If we have leaky gut oxalates that are usually excreted in our feces can easily enter our blood stream. Also many will consume a lot of raw greens. Spinach and Kale are very high oxalate and can increase oxalates in the body. We have oxalate degrading microbiota and if antibiotics or farm chemicals in our food kills them our oxalate levels can indrease. I have posted on my blog on how to deal with those issues.

Bile, an aqueous solution produced and secreted by the liver, consists mainly of bile salts, phospholipids, cholesterol, conjugated bilirubin, electrolytes, and water.The liver cells are mostly hepatocytes. Bile travels through the liver in a series of ducts, eventually exiting through the common hepatic duct. Bile flows through this duct into the gallbladder where it is concentrated and stored. When stimulated by the hormone cholecystokinin (CCK), the gallbladder contracts, pushing bile through the cystic duct and into the common bile duct. CCK is usually deficient in those with inflammatory bowel disease. Cholecystokinin is released after a meal is consumed. It is stimulated by the production of stomach acid. It is secreted along with secretin. Secretin stimulates bicarbonate in response to the acid from the chyme that enters the small intestin, and It stimulates pancreatic enzymes and forces bile into the small intestine. If we do not produce enough stomach acid then Cholecystokinin is not released and our food will sit in our stomach and ferment. This causes and increase of either methane producing bacteria or sulfur digesting bacteria. Methane and sulfur digesting bacteria cause lower motility in the intestines slowly digestion even more. Bile is needed to stimulate the Vitamin D Receptor.

Simultaneously, the sphincter of Oddi relaxes, permitting bile to enter the duodenal lumen. Lumen is the space in a tubular shape. The hormone secretin also plays an important role in the flow of bile into the small intestine. By stimulating biliary and pancreatic ductular cells to secrete bicarbonate and water in response to the presence of acid in the duodenum, secretin effectively expands the volume of bile entering the duodenum. In the small intestine, bile acids facilitates lipid digestion and absorption. Bile is needed to absorb many nutrients especially lipid (fat) soluble vitamins like Vitamin D, Vitamin E, , Vitamin A and Vitamin K. Only approximately 5% of these bile acids are eventually excreted. The majority of bile acids are efficiently reabsorbed from the ileum, secreted into the portal venous system, and returned to the liver in a process known as enterohepatic recirculation. Ileum is the final section of the small intestine.

If bile becomes inhibited it inhibits the vitamin D receptor further inhibiting bile production and adding to the problem because cholesterol production and conversion becomes inhibited. This will make bile become sludgy leading to low bile flow which will increase estrogen levels and cause high unbound copper levels in the blood. Bitter herbs increase bile flow but the vitamin D receptor has to be addressed along with balancing the microbiome in the gut and healing the intestinal tract. Inflammation needs to be reduced , and prevent thrombosis. There are many things that can block the portal vein. The above mentioned things and also thrombosis can cause it. Thrombosis is blood clotting.

This is why I often times recommend grape seed extract and bacopa to people. It prevents thrombosis. Inflammation because endotoxins can cause thrombosis. Grape seed extract and bacopa reduce inflammation and prevent thrombosis. If thrombosis occurs in the portal vein it will effect the liver, pancrease, and digestive system. This causes pain in the stomach, bloating, inflammation, pancreatic pain, pain in the gallbladder. This can lead to death. Bile flow will become inhibited speeding up the progression of portal vein thrombosis. Those with hepatitis need to use hawthorne or something else. Resveratrol activates hepatitis.

portal vein thrombosis

gastrointestinal symptoms (ex: abdominal pain, nausea, vomiting, and diarrhea), fever and constitutional symptoms (ex: fatigue, malaise, and anorexia/weight loss) [3]. We can also find hepatomegaly with elevated liver enzymes and jaundice [3], when associated with liver abscess or cholangitis [2]. Laboratory tests usually demonstrate elevated markers of inflammation [2]

https://www.journalmc.org/index.php/JMC/article/view/3050/2378

If not addressed in time it can lead to portal hypertension. This results in brain swelling, abdominal swelling . Confusion, anemia and low white blood cell count.

https://my.clevelandclinic.org/health/diseases/4912-portal-hypertension

How Bile is Formed.

Bile is produced by hepatocytes, which is then modified by the cholangiocytes lining the bile ducts. The production and secretion of bile require active transport systems within hepatocytes and cholangiocytes in addition to a structurally and functionally intact biliary tree. If this becomes blocked by stones from poor bile production, oxalates or infection a person can develop choledocholithiasis. This will cause problems with the gall bladder, liver, kidneys and digestion. This can also lead pancreatic problems. The symptoms are upper abdominal pain, nausea and vomiting.

Initially, hepatocytes produce bile by secreting conjugated bilirubin, bile salts, cholesterol, phospholipids, proteins, ions, and water into their canaliculi (thin tubules between adjacent hepatocytes that eventually join to form bile ducts). Unconjugated bile is when heme is released during red blood cell break down, the remainder is converted to unconjugated hemoglobin. This form of bilirubin travels from the blood stream to the liver. If the liver cannot convert unconjugated to conjugated it will build up in the blood and a person will develop a yellow like glow. It is normally excreted through the intestines. If there is a rapid destruction of blood cells this can also happen. Infections, toxins, excess vitmin C and excess iron can cause the red blood cells to break down. Conjugated bilirubin is water soluble and if there is a blockage it will be excreted in the urine. Testing for high bilirubin in the urine can help identify blockage.

The canalicular membrane of the hepatocyte is the main bile secretory apparatus which contains the intracellular organelles, the cytoskeleton of the hepatocyte and carrier proteins. Fluctuations in cytosolic and organelle Ca2+ following glucagon or epinephrine stimulation play a major role in hepatic control of glucose production, bile fluid movement and excretion, fatty acid, amino acid and xenobiotic metabolism, protein synthesis and secretion, cell cycle and cell proliferation, among other functions. I discussed in some of my other post about autophagy. It can help issues like this.

The carrier proteins in the canalicular membrane transport bile acid and ions. Transporter proteins found within the canalicular membrane use energy to secrete molecules into bile against concentration gradients. The citric acid cycle is involved in providing the energy for this to occur. Mitochondrial disfunction and a loss of ATP can also interfere with this process. If this occurs cholestasis can occur causing a backup of bile and it can enter the blood stream. If the problem causing the obstruction is not addressed it can lead to fibrosis and vanishing bile duct syndrome. Symptoms are frequent itchy skin, elevated triglycerides, fat growths that appear under the skin. Drugs are often times the cause especially fluorquinolones.

Through this active transport, osmotic and electrochemical gradients are formed. When conjugated bile salts enter the canaliculus, water follows by osmosis. The electrochemical gradient allows for the passive diffusion of inorganic ions such as sodium. The most significant promoter of bile formation is the passage of conjugated bile salts into the biliary canaliculus. The total bile flow in a day is approximately 600 ml, of which 75% is derived from the hepatocyte, and 25% is from the cholangiocytes. Approximately half of the hepatocyte component of bile flow (about 225 ml per day) is bile salt-dependent and the remaining half bile salt independent. Bile Salts are formed in the body by combining bile acids and alcohol sulfates. Bile acid is combined with glycine or taurine to form bile salts. This is a good article explaining how to increase bile salts and the benefits of doing so. Taurine has been found to increase sulfur digesting bacteria which would increase H2S which can inhibit bile production. The is most likely why the western diet causes health problems it is high in taurine.

https://draxe.com/bile-salts/

Osmotically active solutes such as glutathione and bicarbonate promote bile salt independent bile flow. Canaliculi empty bile into ductules or cholangioles or canals of Hering. The ductules connect with interlobular bile ducts, which are accompanied by branches of the portal vein and hepatic artery forming portal triads. Bile is subsequently modified by ductular epithelial cells as it passes through the biliary tree. These cells, known as cholangiocytes, dilute and alkalinize the bile through hormone-regulated absorptive and secretory processes. The hormones are scecretin, acetycholine, ATP, and bombesin. So you can see the importance of making sure we address any issues we have that can inhibit acetylcholine production or cause ATP to become depleted. Issues with glycolysis can cause a loss of ATP. I do not know much about increasing ATP except that creatine helps increase ATP production.

The cholangiocytes have receptors which modulate the bicarbonate-rich ductular bile flow, which is regulated by hormones. These receptors include receptors for secretin which regulates water homeostasis, somatostatin decreases stomach acid production, cystic fibrosis transmembrane conductance Regulator (CFTR) not sure how to describe this one. It is kind of an ion channel/ABC transporter and chloride-bicarbonate exchanger this is where electrolytes are important. These are listed in order of importance sodium, calcium, magnesium and postassium .

For example, when secretin stimulates receptors in the cholangiocyte, a cascade is initiated which activates the CFTR chloride channel and allows the exchange of bicarbonate for chloride. In contrast, somatostatin inhibits the cAMP synthesis within the cholangiocytes causing the opposite effect. While bombesin, vasoactive intestinal polypeptide, acetylcholine, and secretin enhances bile flow, somatostatin, gastrin, insulin, and endothelin (endothelin are involved in electrolyte homeostasis) inhibit the flow. I do not have enough experience with reducing insulin levels and had to have a friend help me with that on facebook. Some metabolic disorders can cause low glucose levels and high insulin levels. It can be corrected but takes someone who is knowledgeable.

Bile Acids Cholesterol catabolism by hepatocytes results in the synthesis of the 2 major primary bile acids, cholic acid, and chenodeoxycholic acid. This process involves multiple steps, with cholesterol 7alpha-hydroxylase (CYP7A1) acting as the rate-limiting enzyme. It is effected by steroid hormones, inflammatory cytokines, insulin and growth factors.

Primary bile acids undergo dehydroxylation by bacteria in the small intestine, forming the secondary bile acids deoxycholic acid and lithocholic acid, respectively. Deoxycholic acid breaks down fats. High protein diet increases deoxycholic acid. Excess lithocholic acid speeds up aging and is carcinogenic. Eating lost of fiber reduces lithocholic acid. Artichoke reduces lithocholic acid and stimulates bile production. If the vitamin D receptor is inhibited then lithocholic acid cannot be detoxed by the body.

Both primary and secondary bile acids are conjugated by the liver with an amino acid, either glycine or taurine. Conjugated bile acids are known as bile salts. Bile salts inhibit cholesterol 7alpha-hydroxylase (CYP7A1) , decreasing the synthesis of bile acids. Despite the increased water solubility of bile salts, they are amphipathic molecules overall (has both hydrophobic and hydropholic molecules). This critical property allows them to effectively emulsify lipids and form micelles with the products of lipid digestion. The bile acid pool is maintained via mainly the enterohepatic circulation and to a small extent (about 5%) by hepatic synthesis of bile acids, as long as the daily fecal loss of bile acids do not exceed 20% of the pool. Micelles help with fat absorption.

Venous blood from the ileum goes straight into the portal vein, and hence through the sinusoids of the liver. Hepatocytes extract bile acids very efficiently from sinusoidal blood, and little escapes the healthy liver into systemic circulation. Bile acids are then transported across the hepatocytes to be resecreted into canaliculi. The net effect of this enterohepatic recirculation is that each bile salt molecule is reused about 20 times, often two or three times during a single digestive phase. When the digestive system is healthy bile gets easily reabsorbed.

Chenodeoxy cholic Acid and Cholic Acid are the primary bile acids produced. From Chenodeoxy cholic Acid many other bile acids are produced.

Bile acid gets reabsorbed and returned to the liver to be recycled. There are secondary bile acids produced in our digestive tract by our gut bacteria. Our microbiome deconjugates bile. Deoxcycholic Acid is a secondary bile acid produced by our microbiome. It is recycled by the body and is conjugated with glycine or taurine and circulated with primary bile acids. It constitutes about 20% of biles acids.

Lithocholic Acid is a secondary bile acid. It is conjugated with glycine or taurine and sulfated producing sulfolithocholylglycine or sulfolithocholyltaurine. Lithocholic Acid is toxic and can destroy the liver. Sulfation is an important part of detoxing deconjugated bile acids. Sulfation of bile acids decreases their absorption rate which prevent them from reentering the liver so when sulfation is functioning properly then the body can easily detox the toxic bile. Sulfation can become inhibited by metabolic issues, high sulfur digesting bacteria raising hydrogen sulfide and sulfide levels in the body. If there are problems with the CBS or BH4 pathways sulfation can be effected. The SULT genes are effected by our hormones. A change in our gut bacteria, toxins, glyphosate, vaccine injury, infections, leaky gut and many other things can change our hormone levels. This can inhibit the ability for the liver to sulfate bile acids. The pregnane X receptor also know as the xenobiotic sensing nuclear receptor has been found to be inhibited in those with bile blockage disorders. Inhibited PXR can inhibit SULT genes. Those with upregulated PXR have been found to be protected from the negative effects of LCA. Constitutive Androstane Receptor (CAR) is involved in sensing and removing endobiotic, and xenobiotic substances. It detoxes foreign substances and drugs. It has be found to protect form LCA when upregulated by inducing SULT genes. CAR is also involved in energy homeostasis. Fasting can induce CAR. Vitamin D receptor, Liver X receptor, and Farnesoid X receptor are also involved in sulfation and upregulation hve been found to protect from LCA. Most of those receptors have been found to be inhibited in those with bile blockage. Showing the importance of supporting their proper function.

When there is an obstruction biles acid can spill over into the blood stream through OST a and b transporters and also can enter the blood through Multidrug Resistance-associated proteins M1M3,M4 and M6. When there is an obstruction urinary excretion of bile is the primary route of bile removal. If this continues for an extended period of time it can lead to bladder irritation from the caustic effects of the bile acid to the bladder. Constipation form inhibited bile flow is common in interstitial cystitis. This can also take place through the organic acisd transporter.

This is an interesting article on bile acid blockage. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1105662

When Lithocholic Acid cannot be sulfated it remains toxic. Lithocholic Acid is highly carcinogenic and causes cancer. High Lithocholic Acid levels inhibits cortisone production this can cause many health issues including chronic fatigue.

Cellulose has been found to increase the mucus membrane which improves bile flow.

Not sure where to go with this information but took note of it. High nitrogen levels increases bile acid oxidation, high hydrogen levels inhibits bile acid oxidation.

https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13064

Medium Chain Fatty Acids stimulate bile production which decreases bacteroides and actinobacteria which has been found to be high in those with dysbiosis and inflammatory bowel disease. Low bile acid production increases levels of microbes that produce potent LPS. Tempo a product made from fermented soy has been shown to reduce bacteriodes and inhibit our microbes ability to produce bile salt hydroxolase which inhibits FXR receptor. By decreasing our microbes bile salt hydrolase bile production is restore which reduces the bacteria that inhibit bile flow. If you try this route you would want to use organic because the BT-Toxin and glyphosate found in soy products destroy the gut and alter our gut microbiome causing an increase in microbiota that have a negative impact on our health. The FXR receptor is responsible for homeostasis throughout the body. If the FXR receptor is inhibited a person will develop diabetes, dislipademia, cancer, metabolic disorders, atherosclerosis and renal diseases.

If a person has cholestasis stimulating bile will damage the liver and cause excess bile to enter the blood causing many other health problems. If a person has cholestasis they should not stimulate bile production. Elevated bile production is a sign and symptom of sepsis which indicates cholestasis.

Things that can cause cholestasis is drugs, infection, metabolic issues, gene issues, gut dysbiosis,inflammatory bowel diseases,hormone imblance, T cell imbalcance, excessive inflammation, toxins and many other things. If a person has cholestasis they will have dark colored urine and light colored stools. Pain in the abdomine, excessive itching, fatigue and nausea. In more severe cases the skin and eyes my get a yellow color.

You have to address the cause of cholestasis if it is drug induced then you may have to discontinue the use of the drug, address infection and inflammation, correct metabolic issues and gene issues. Work on reducing gall stones and oxalate stones.

Some things found to help with bile blockage. Gaur Gum, milk thistle, dandelion, vitamin K, Vit D, Calcium but we must make sure we get the right type, sunflower seed lecithen, antioxidants but do not over use homeostasis is the goal. We need some oxidative stress if we completely disable ROS we will defeat the purpose. Radishes have been shown to help with bile blockage. Cod liver oil helps with bile blockage, medium chain fatty acids help with bile blockage, curcumin helps with bile blockage but after a while it should be pulsed because it chelates iron from the body and can cause anemia. Activated charcoal helps with cholestasis but should not be taken close to meals or we will lose nutrients. Soaking in epsom salt and then getting far infrared, sunlight or halogen light gives us magnesium sulfate which helps with cholestasis. If it is caused by gall stones apple juice and apple cider vinegar has been found to reduce gall stones. Lemon juice has been found to reduce gall stones. I had to put lemon juice in water because straight lemon juice was to strong for me and made my stomach hurt. Artichoke has been found to reduce gall stones. We need a variety in our diets, eating poorly can cause bile stones. The more processed foods we eat the better our chances of getting them are. Losing weight too quickly can also cause gall stones. Low HDL levels can cause gall stones that can be caused by hormone imbalances especially high estrogen levels. Citrus fruits reduce gall stones especially the white part of the fruit. Rosemary has been shown to reduce gall stones. Pear juice has also been found to dissolve gall stones. Beet root, carrots and cucumber has been found to reduce gall stones. Drinking excess amounts of soda pop and consuming excess amount of processed sugar can cause gall stones and oxalate stones.

Excess vitamin C can cause oxalates but normal levels help dissolve oxalates. High meat consumption increases oxalates, excessive salt consumption can cause high oxalates, soda pop contains phosphoric acid which increases oxalates and causes kidney stones. Excess vitamin D intake can cause oxlates most do not recommend get more then 5000 IU of vitamin D and many say 60 IU is enough. High meat consumption can decrease citrate in the body, citrate prevents oxalates. If a person take magnesium citrate it should not be taken often because the body recycles citrate and it can build up in the body causing liver and kidney damage. If a person has metabolic issues that cause acidosis it can lead to oxalates, I post on addressing acidosis. DNA damage from oxidative stress or health issues can cause high uric acid levels which can increase oxalates. Omega 3 oils help reduce oxalates. Celery, carrots, pomegranate, watermelon, pumpkin seed oil. Helps reduce oxalates. Horsetail herb helped me a lot but has an alkaloid that can build up in the body so should not be taken more then three times a week. Citric acid not to be confused with vitamin C reduces oxalates this is why lemon is very good for reducing oxalates. Bear berry and uva ursa contain berberine which reduces oxalates and uric acid. Stinging nettles reduces oxalates and toxins that can cause oxalates. Stay hydrated but avoid water that has been chlorinated or fluorinated it is toxic an increases oxalates.

High Trymethylamines produced from our microbiome breaking down choline and carnetine is converted by Flavon Mono-Oxygenase 3 to Trymethylamine-N-Oxide. TMAO inhibits bile production. Olive oil has been found to prevent our gut microbiome from producing Trymethylamines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215539/

Crushed flax seed and oat haul increases bile flow.

If we do not correct the health issues causing our bile receptors to be inhbited it can lead to Non Alcohol Fatty Liver Disease.

https://gut.bmj.com/content/67/10/1881.long

Balancing the immune system

https://iamajuicer.wordpress.com/2018/07/15/autoimmunity-what-causes-it-and-things-that-may-correct-it/

Reducing oxalates.

https://iamajuicer.wordpress.com/2018/07/13/high-oxalates-also-know-as-oxalosis-or-hyperoxaluria/

Healing the gut is very important.

https://iamajuicer.wordpress.com/2018/12/01/things-that-can-go-wrong-in-the-gut-and-how-you-may-be-able-to-correct-them/

information on our gut microbiome.

https://iamajuicer.wordpress.com/2018/11/19/true-cause-of-illness-and-things-that-may-help/

Things that may help with infections.

https://iamajuicer.wordpress.com/2018/08/12/herbs-that-help-with-infection/

Things that can break down scare tissue in the body is autophagy which I have posted on and HSP70 which is another thing I have posted on. Serrapeptase has been shown to break down calcium deposits and aggregates in the body. It must be used with caution. High dosage can start breaking down tissue in the body but low dose will reduce inflammation and help the body heal.

https://iamajuicer.wordpress.com/2018/07/22/heat-shock-proteins-and-their-effects-our-our-health/

Inflammation and toxins is why so many are ill now days.

https://iamajuicer.wordpress.com/2018/11/19/true-cause-of-illness-and-things-that-may-help/

Things that can go wrong in the gut and how you may be able to correct them.

This is not medical advice I am posting this for educational and informational purposes.

 

Always remember homeostasis is the goal.

This is not finished but I need to work on other things and I figure this will give people a good foundation to research and build on.

Lipopolysaccharide (LPS) is usually used when referring to pathogens. Our commensal microbes produce LPS which our body uses to identify them. Normally they are not harmful to the body and some of the other commensal consume LPS keeping levels down. But a loss of those commensal or leaky gut can cause LPS to enter our blood streams which can lead to sepsis so it is very important to protect and maintain the health of our guts.

If we develop leaky gut and do not correct it toxins like mercury that can be in our food and usually will get excreted can now easily enter the blood stream and a person may develop high levels of mercury, cadmium or other toxins in the body.

If you have leaky gut oxalates that usually get excreted can enter the body. It is very important to heal the gut because oxalates are very damaging to the body. Calcium will bond with oxalates preventing them from being absorb and is why if a person is lactose intolerant they need to work on correcting it because milk with meals would help prevent that. Some calcium supplements are not good for you so if you decide to take that route make sure you do your research. Once oxalates build up in your body it prevents the gut from healing so it is very important to reduce oxalate levels. I have posted on reducing oxalates.

There are 2 components to the intestinal barrier. Intrinsic barrier and extrinsic barrier.

Intrinsic barrier is composed of the epithelial cells lining the digestive tube and tight junctions that tie them together.

Our gut bacteria maintain the health of our gut but damage to our gut can inhibit FUT2 production. Our gut microbiome cannot get established if we are deficient in FUT2. Lactobacillus Casei increases FUT2 production by inducing ERK/JNK. Inducing ERK/JNK stimulates FUT2. Nitric Oxide induces ERK/JNK, arginine rasises NO levels. Hypoxia induces ERK/JNK. Interleukin 10 inhibits FUT2 so a person may want to be cautious when taking probiotics that stimulate IL-10. Lactobacillus species of microbiotia stimulate IL-22 especially L Johnsii. IL-22 stimulates FUT2 secretion.

Extrinsic barrier consist of secretions and other other influences like microbes that influences the epithelial layer but are not physically part of the epithelium cells and maintain their barrier function.

Intrinsic Intestinal Barrier.

The gut is lined by sheets of epithelial cells that define the structure of the mucosa they are tied together by tight junctions, which paracellular spaces and thereby establishing the basic gastrointestinal barrier. Paracellular spaces are were nutrients are transported into the blood stream and toxins can be transported to the intestines for removal. Toxins and microbes that are able to breach this barrier have unimpeded access to the circulatory system. The tight junction layer and the mucus membrane for the most part prevents this from happening when healthy. Some cells in the epithelial are not effected by acid but others do not have the protection so count on the mucus membrane to protect them.

Extrinsic Barrier

Mucus that coats the entire epithelium. Hormones and cytokines that regulate the function of our digestive system and maintain digestive health. Our gut microbiome are a part of the extrinsic barrier. They reside in the mucus membrane.

Tight junctions encircle the epithelial cells and are an important part of the intrinsic layer. Their permeability is regulated by zonulin.

Tight junction controls the equilibrium between tolerance and immunity to non-self antigens. It is involved in macromolecular transport and tolerance and immune balance. If the tight junction layer becomes too porous a person may develop autoimmunity and their bodies immune system will turn on the body and start causing autoimmune disorders. A person will develop food allergies and food intolerances. The longer this goes without being addressed the more a persons health will decline. They will develop many metabolic, genetic and immune dysfunctions. Many things can damage this vaccines have been shown to raise B cell levels which causes the tight junction layer to become more porous. BT Toxins in GMOs have been shown to cause the body to react in a way that the tight junction layer becomes more porous. Many farm chemical cause it to become more porous especially glyphosate and glufonisate cause it to become more porous. Stress and trauma can also cause the tight junction layer to become more porous.

Zonulin is the only intercellular modulator of the tight junctions. If zonulin becomes over expressed the gut becomes more porous leading to leaky gut. It is involved in the transport of macromolecules and in balance between tolerance and immune response balance. If zonulin becomes deregulated it can cause inflammatory bowel, anemia, systematic inflammation, red sore areas on the skin known as Sweet’s syndrome that can eventually develop into blisters that eventually turn ulcerative which is known as Pyoderma Gangrenosum. They can develop swelling and sores in the mouth. The eyes can become red sore and inflamed. This condition is called sceritis it can lead to uveitis which effects the iris and can lead to blindness. Bones may thin and become brittle. Oxalates will develop causing stone formation this can also effect the liver. Not only can it cause endogenous oxalates to be produced but now oxalates consumed in our foods that are normally excreted can readily enter the body. Gall stones may form because bile production and pancreatic enzymes become inhibited and a person can develop chronic diarrhea, constipation or alternate between the two.

When the bile is inhibited it is called Primary Schlerosing Cholangitis. From food particles and toxins entering the blood stream a person could start having excessive blood clotting. A person will start developing nutrient deficiencies from being unable to absorb and break down nutrients properly. A person will eventually develop high histamines if this continues they may develop asthma, they can start developing sarcoidosis throughout the body. Mast Cells can start to degranulate leading to mastocytosis or mast cell activation syndrome. This effects our immune system as you will see below. It can lead to diabetes, heart disease and many other chronic illnesses. It can also lead to obesity or anorexia depending on how the person has been effected.

In order to restore zonulin levels to normal the genetic, metabolic, oxidative stress, changes in ph for example if you have developed acidosis or alkalosis it will have to be addressed along with infections that come along with our immune system being disabled. I have posted on most of those issues and correcting them. There are three isoforms of zonulin. ZO- 1 , ZO-2 and ZO-3.

When we get an infection it is a sign we are lacking a nutrient or gut microbe that protects us. The infection produces lipopolysaccharide (LPS) which stimulates zonulin making our guts more porous. Also antibiotics can kill the butyrate producing gut bacteria which makes our gut more porous. Butyrate keeps many things at homeostasis. We cannot restore normal zonulin levels if we do not replace the butyrate producing bacteria and feed them with fiber, oligosaccharides, galactosaccharides, and fructooligosaccharides. The lower the diversity of our gut microbes the higher our zonulin levels will be showing that our digestive system needs feedback from a variety of microbes to function properly.

The fun part of all of this is they will tell you all this in in your head until you are so ill it will take months or years to heal. In the mean time they will still continue to treat the symptoms instead of the cause. It is a common theme with allopathic medicine. I have seen this with naturopathic also but for the most part naturopaths treat the cause and not the symptoms.

Things that can reduce zonulin is meditating, if you have experienced trauma work very heard to move forward. It is difficult not to look back but constantly looking back causes stress and can increase zonulin. Anger increases zonulin so try to learn to deal with frustration and bad situations in a calm way , the calmer we are the lower our zonulin levels will be.

Replace the butyric acid producing bacteria I listed many microbes that produce it if you search my blog.

Inflammation and immune dis-regulation and can increase zonulin so the microbes that increase T regulatory cells and inflammation will reduce zonulin. If your immune system has been disabled then microbiome that stimulates IL-10 will help restore immune function.

High LPS levels will increase zonulin so we need the gut microbes that reduce LPS. Studies have shown the higher our guts diversity the less ZO-1 is express which prevents leaky gut and inflammation.

Under normal conditions things with gliadin , glutin and lactose will not effect a healthy gut but increase zonulin when the mucus membrane is damaged.

There are many molecules that interact with each other to maintain the Zonulin layer and the tight junction layer.

Occludin plays a role in tight junction maintainence and assembly which is regulated by phosporylation of serine, threonine, and tyrosine risidues. It is important for maintaining TJ stability and function. Loss of occludin can lead to leaky gut, inflammatory bowel, and hyperplasia most likely from the inflammation. Occludin also regulates cell survival or death through the intrinsic system. It is important in receiving and transmitting cell survival signals. Occludin has a strong inhibitory effect on cancer. Loss of Occludin leads to cell death.

If Phosphorylation of tyrosine, threonine and serine residues is inhibited it reduces occludins interaction with zonulin. Dephosphorylation of ser/thr residues and poor phosphorylation of tyr residues causes a reduction in occludins interaction with ZO-1 leading to it’s seperation from the junctional complex and TJ disruption. It also leads to excess ROS production which increases gut permeability. Inflammation reduces occludin levels. Endotoxins also reduce occludin. Another function of occludin is in modulating the TJ response to cytokines to protect and heal the tight junction. Occludin plays an active role in cellular location of caveolin-1. Caveolin-1 is required for cytokine induced TJ barrier changes, where it is required for TJ remodeling. So addressing endotoxins, high B cell or T cell levels and reducing inflammation is very important for preserving occludin. Many of our commensals that increase T regulatory cells balance our immune system which would restore proper T and B cell levels. Many of our commensal microbes reduce inflammation and reduce LPS (endotoxins). I have posted on my blog which of those accomplish these things. TNF-a is involved in caveiolinn-1 mediated internalization of occludin which increases occludin, alleviating cytokine induced gut permeability. This can be induced by TNF-a which is an inflammatory cytokine.

Mucous Membrane

The mucus membrane is thin in most inflammatory bowel diseases but is thick in Chron’s disease which I have not researched much on. Inflammtion usually causes the globin which are the mucin secreting cells to become depleted but for some reason this does not happen in Chron’s disease.

All these genes listed below are negatively effected by leaky gut. It is very important to reduce inflammation and work on getting the gut healed to restore the mucous membrane. Damage to the digestive system and mucus membrane causes many genes to become dis-regulated. MUC2 gene is the major gene responsible for the secretion of gel-forming mucin in the intestinal tract. It coats the endothelial surface protecting it from inflammation,chemicals, damage and infection. There are 20 MUC genes. There are many mucin categories that are enriched with proline, serine, and threonine. They are modified by o-glycosylation that creates oligosaccharides that confer on mucins their individual functions. Mucin is made mostly of fat. Those with inflammatory bowel and ulcerative colitis have low B-oxidation which is needed for the break down and use of fats. Since the mucous membrane is mostly fat this causes it to become dysfunctional. This makes people sensitive to fats and is why it is best if they consume medium chain fatty acids because the body can readily use them. Eggs yolks are a good source of phosphatidylcholine which is what the mucus membrane is mostly made of. Most with inflammatory bowel or colitis are sensitive to lecithin. I used sun flower seed lecithin and I did not react to it and it helped me a lot with my healing. Most other sources of lecithin I had to avoid. There are many studies showing that using sun flower seed as a source of lecithin has been shown to heal the gut. As for Chron’s disease I have a theory I have not had a chance to research but I believe they may be deficient in commensal microbes that digest sialic acid. Many of our commensals need it to thrive. Bacteroides Fragilis, Bacteroides Thetaiotaomicron, Bifidobacterium Bifido, Bifidobacterium Longhum, Bifidobacterium Infantis, Akkermansia Muciniphila all need sialic acid to thrive. Another theory I have about Chron’s that I have not gotten to research is they may have an overgrowth of those and that inflammation or LPS is stimulating the production of excessive sialic acid causing and overgrowth of those microbes.

Phospholipase A2 activity is higher in those with inflammatory bowel and colitis.

If a person is having trouble with methyl donors they will not produce enough phosphatidylcholine because methyl groups are used in the process of producing phosphatidylcholine for the mucous membrane. So combine that with the low B-oxidation and you see why it can be so difficult to heal. Disulfide bridges are also a component of phosphatidylcholine showing the importance of addressing things that can impair sulfation.

Phospholipase A2 is high in those with inflammatory bowel and colitis. Phospholipase is stimulated by inflammation. It is a mixture between inflammation and substance P and is why those with leaky gut have high substance P levels. When substance P levels get high the skin will have a burning sensation especially in the scalp and it may go down the spine. Substance P levels increase at night so the symptoms will worsen at night.

Annexin also known as lipocortin keeps PLA2 in check. Adrenal hormones increase Annexin but in many people with inflammatory bowel the adrenals become depleted from being over activated and they develop Addison’s disease which is a deficiency of adrenal hormones. Adaptogens help alleviate this which would help restore annexin levels. Annexin also helps repair our immune system. If annexin gets low the blood brain barrier becomes porous because it helps maintain the blood brain barrier. Annexin is also involved in protecting the brain from infection. It is very important to support the adrenals with the proper nutrients and to reduce inflammation so the adrenals can recover. Oddly Okadaic Acid a toxin found in shell fish increases annexin. This is something a person would definitely need an experienced medical professional to do. IL-6 increases annexin expression. To restore normal cortisol levels stress management is very important. Increased stress depletes cortisol. Getting rest is important, even if you cannot sleep just laying and resting can help increase cortisol. Avoid, caffeine, alcohol and smoking. Our mucosal layer will take up fats and integrate them to strengthen itself. Omega 3 oils, cod liver oil, nuts, and avocados help increase cortisol. Avoid processed sugar it depletes cortisol levels. Citrus fruits especially grape fruit increases cortisol but grape fruit inhibits certain cytochrome P450 enzymes so should not be eaten too often. Eat foods high in melatonin or take melatonin supplements at night which will increase cortisol. Non processed carbohydrates help increase melatonin. Magnesium is important for maintaining proper cortisol levels. Reducing inflammation can help normalize cortisol levels. Earth grounding and getting sunlight help to normalize cortisol levels. I still laugh when I mention earth grounding because I thought how could something so simple have so many health benefits. So I was determined to find research to show those earth grounders were crazy instead it was I who was crazy and the earth grounders are correct. I could find no research to prove them wrong but plenty of research showing the many health benefits of earth grounding.

We have to keep in mind goblet cells build our mucus membrane and when inhibited by inflammation, toxins or even damage to our digestive system our ability to produce mucin is reduced or inhibited. Bismuth even though it is a metal, is for the most part none toxic it takes very high doses for a very long time to reach toxic levels. It helps the gut heal. It kills many pathogens and can cause commensals that have turned pathogenic to go back to commensal. Mucilage helps protect the gut so it can heal. I have posted on reducing inflammation if you search my blog. Oatmeal is high in mucilage but you must get organic because they use glyphosate and glufonisate on grains and beans to dry them and those destroy our gut and kill our gut microbes. Three very good sources of mucilage is okra, arrow root and oatmeal. Make sure the oatmeal is organic. Most non organic oatmeal has farm chemicals that destroy the gut.

Here is an in depth article on mucus membranes.

https://www.readkong.com/page/the-interaction-of-the-gut-microbiota-with-the-mucus-1350713?p=1

Sialylation has been found to be increased in those with inflammatory bowel dieseases. Excessive sialylation increases inflammation. IL-10 inhibits Sialylation. Their are probiotics that increase IL-10 but IL-10 inhibits FUT2. So an oligosaccharide,galactosaccharride and fructosaccharide would probably have to be supplemented with it. I suspect the body is trying to increase the commensals that rely on the nutrients produced by sialylation and they have been depleted by antibiotics. Some commensals rely on FUT2 but others rely on sialylatin. Some do not produce the enzymes to break down sialic acid and rely on other commensals to produce it. A deficiency in either of them is probably what is causing the high sialylation. The body is trying to feed them. It is not getting the feedback from those commensals.

The bacteria this would help thrive are B Fragilis, B Theaiotaomicron, B Bifidum, B Longhum, B Infantis and A Muciniphila. I believe those with inflammatory bowel especially those with Chron’s will be deficient in those because those with Chron’s have a thicker mucous membrane.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747158/

The increased inflammation and infection caused by the above mentioned things results in an accumulation of ROS which can lead to further damage and it disturbs mitochondria function and autophagy. Once the mucus membrane has been damaged all the things mentioned below lose their protection and become dysfunctional. It may be necessary to take mucilage and bismuth to help protect them and restore their function. Once the mucus membrane breaks down it creates a cycle that has to be broken because the mucus membrane needs the things mentioned below to function properly and they need the mucus membrane to protect them and to function properly. Dysfunction in either of them from infection or toxins can start a cycle that has to be broken to heal. Our gut microbiome cannot become established without the mucus membrane because it also protects them. Our mucus membrane is a mediator between host and microbiota interactions. Decreased mucus membrane thickness causes a change in our gut microbiome and makes us more prone to infections.

This is where addressing sulfation issues, methyl group issues and issues with thiols comes in because the production of mucin requires all of those to be functioning. I have posted previously on how to deal with those issues. For the production of the oligosaccharides the endoplasmic reticulum and stem cell are required.

L-cysteine, L-arganine, L-threonine, L-serine, and L-cysteine increase mucin production in the digestive system and have been shown to promote gut microbiome homeostasis. Citrus fiber increases mucin especially the white part of the fruit. Pectin stimulates Goblet cell formation which secretes mucin. The microbiome that help restore gut health are Bifidobacterium Bifido, Bifidobacterium Breve, Bifidobacterium Lactis, Enterococcus Faecium, Lactobacillus Acidophilus, Lactococcus Lactis

For those who do not have glutamate issues bone broth heals the gut very quickly. Those who have high levels of sulfur digesting bacteria will have problems with the consumption of bone broth also.

The small intestine is the portal for the absorption of most nutrients in the body. The chyme which is the digested food that has exited the stomach enters the small intestine pancreatic enzymes and bile is secreted. This breaks the food down and if functioning properly it will be almost liquid when it enters the lower intestinal tract. Bicarbonate is also added by the body to reduce the acidity before it enters the large intestine. The enteric nervous system and gastrointestinal hormones regulate this process and the intestinal motility. Intestinal dysbiosis can cause incorrect communication or inhibited communication which leads to inflammation, intestinal damage and it could lead to a loss of the ability to produce bile and digestive enzymes. To restore proper function we must reduce the microbe causing the problem. Those who have high sulfur digesting bacteria will develop high hydrogen sulfide levels which interferes with sulfation and can interfere with the proper function of the CBS and BH4 pathways. This can lead to high sulfide levels in the body. BH4 levels will become low causing ammonia to build up when protein is consumed. The high ammonia levels will cause some commensals to go into protection mode and they will become pathogenic. Candida and H Pylori are two examples. To make matters worse they also start producing ammonia to protect themselves from the acidic environment. The digestive tract is supposed to be acidic. Ammonia alkalizes it this also makes us more prone to infections because the commensal microbes that protect us cannot survive in an alkaline environment. When we lose our commensal bacteria we lose proper immune function and our zonulin levels increase and our gut becomes more porous leaving things enter the blood stream that could not normally enter. Inflammation and oxalates can inhibit bile flow causing it to back up, when this happens the gallbladder is effected. Instead of addressing the problem modern medicine gets rid of the symptom by removing the gallbladder thus the illness continues to worsen and taking the gallbadder out can contribute to it’s progression.

If bile becomes inhibited it inhibits the vitamin D receptor further inhibiting bile production and adding to the problem because cholesterol production and conversion becomes inhibited. This will make bile become sludgy leading to low bile flow which will increase estrogen levels and cause high unbound copper levels in the blood. Bitter herbs increase bile flow but the vitamin D receptor has to be addressed along with balancing the microbiome in the gut and healing the intestinal tract.

This is why I often times recommend grape seed extract and bacopa to people. It prevents thrombosis. Inflammation because endotoxins can cause thrombosis. Grape seed extract and bacopa reduce inflammation and prevent thrombosis. If thrombosis occurs in the portal vein it will effect the liver, pancrease, and digestive system. This causes pain in the stomach, bloating, inflammation, pancreatic pain, pain in the gallbladder. This can lead to death. Bile flow will become inhibited speeding up the progression of portal vein thrombosis. Those with hepatitis need to use hawthorne or something else. Resveratrol activates hepatitis.

portal vein thrombosis

gastrointestinal symptoms (ex: abdominal pain, nausea, vomiting, and diarrhea), fever and constitutional symptoms (ex: fatigue, malaise, and anorexia/weight loss) [3]. We can also find hepatomegaly with elevated liver enzymes and jaundice [3], when associated with liver abscess or cholangitis [2]. Laboratory tests usually demonstrate elevated markers of inflammation [2]

https://www.journalmc.org/index.php/JMC/article/view/3050/2378

If not addressed in time it can lead to portal hypertension. This results in brain swelling, abdominal swelling . Confusion, anemia and low white blood cell count.

https://my.clevelandclinic.org/health/diseases/4912-portal-hypertension

Autophagy is very important in maintaining health and we need a proper balance. It can be disrupted if we have intestinal damage. If autophagy is inhibited we become prone to infection and mitochondrial dysfunction. Autophagy is the housekeeper of our cells. One common theme you will see is inflammation and shows the importance of reducing inflammation. Which could involve diet changes, addressing metabolic issues, reducing toxins and infections. Addressing detox issues and detoxing in an appropriate manor for the individual. Addressing gene issues which could be caused by any number of things including a lack of the microbe in the gut that may modulate that genes function.

The mucus membrane in our digestive system protects us from infection, physical and chemical harm. Our commensal bacteria cannot exist without it. It is very important to restore our mucus membrane when damaged in order to restore intestinal homeostasis. Many genes mentioned below are effected when it is damaged because it causes a dysfunction in them. Autophagy is very important for the maintenance or proper gene function.

Paneth cells are located within our mucus membranes and provide immunity, prevent damage to the digestive system and is involved with nutrient absorption. Loss of our mucus membrane from loss of microbiotia, drugs or farm chemicals found in our food can destroy our mucus membrane. This causes damage to the digestive system which can further inhibit the bodies ability to produce mucin. This makes us more susceptible to infection. Paneth cells stimulate the production of AMPs which fight infection and modulate commensal microbiome and innate immunity. A list of AMPs are defensin-like human lyzosome, defensin (HD)-5 and 6, lyzosome, regenerating islet derived gamma(Reg3y), and phospholipase A2 group 2A(sPLA2) as well as inflammatory cytokines such as Transforming Tumor Necrosis Factor A (TNF-a), Growth Factor B1 (TGF-B1), and Postaglandin E2. AMPs are sensitive to ER stress which I discuss below.

Autophagy protects against infection by producing Antimicrobial Peptides and degrading organelles that break down misfolded proteins and AMPs break down pathogens. This can ease the over activated inflammatory response and over active immune response. Some AMPs are defensin and cathelicidens which protect against microbes.

Intestinal Epithelial Cells. (IECs) – form a physical and chemical barrier involved in inflammatory response and immune reaction. IECs work as an interface between the quantitive microbial ecosystem in the intestinal lumen. Lumen is inside space or opening in a tubular structure.

There are 6 types of IECs

Goblet Cells which secrete mucin to build up the mucin barrier.

Enteroendocrine cells which produce gastrointestinal hormones that communicate with the nervous system, the brain and organs throughout the body. They respond to nutrients within the intestines. Helps restore intestinal tissue.

Absorptive Enterocytes – epithelial cells in small intestine. They are involved in nutrient absorption, absorption of conjugated bile acid, lipid uptake, Issues with Absorptive Enerocytes can inhibit glucose absorption and can result in lactose intolerance and many other food intolerances. It can also result in an electrolyte imbalance. Enterocytes secrete a series of chemokines and cytokines which regulate immune responses of subjugant mucosal. (Mucosal control)

Tuft Cells – brush cells which are chemosensory cells in the intestinal epithelial lining. Tuft refers to microvilli projecting from the cells. They increase during parasite infection. They are the sole source of Interleuken 25 which induces NF-kB activation which helps protect from infection. High levels of IL-25 raises eosinophils which causes inflammation and is suspected of causing inflammatory bowel diseases. Eosinophils have been shown to kill many types of cancer cells. Infection also stimulates Tuft Cell to produce IL-25. They are increased through a T cell response through a type of lymphatic tissue. Tuft cell also secret endogenous opioids. Eosinophils cause asthma, cardiovascular disease and can even cause headaches, mood swings and brain fog.

Microfold Villous Cells – are found in the Gut-associated Lymphoid Tissue (GALT) of the Peyers Patches in the small intestine and the Mucus-associated Lymphoid Tissue (MALT). M Cells initiates mucosal immunity. They allow the transport of microbes and across the epithelial cell layer. From the gut lumen to the lamina propria. M cells contain Epidermal growth factor which acts as a sensor to stimulate repair through the intestines including the mucus membrane , tight junction protein layer and it stimulates goblet cell differentiation and many other things in the colon.

Endoplasmic Reticulum are organelles within our cells and plays a major role in the production of proteins and lipids. So this is where our enzymes , hormones and even our detox enzymes are produced.

Endoplasmic Reticulum Stress Unfolded Protein Response (UPR) is activated in response to unfolded or misfolded proteins in the endoplasmic reticulum. It stops the production of unfolded or misfolded proteins it is the quality control mechanism. It will stop production and start cleaning the bad proteins out. If it continues for too long then it will induce apoptosis which is cell death. If overactivated which vaccines and many farm chemicals can cause to happen it can lead to prion disease. It plays a valuable role in intestinal endoplasmic reticulum survival and function. Dysfunction of endoplasmic reticulum can result from genes that have been effected from infection, toxins, or even stress can result in abnormal UPR function. This is referred to as Endoplasmic reticulum stress.

ER stress activates three kinds of proteins which reside in the ER membrane to detect UPR in ER Lumen and resolve them. Autophagy reduces ER stress.

inositol-rquiring membrane kinase endonuclease1 (IRE1) via a really long pathway that I am certain you do not want me to type out. Issues with the genes involved in these mediators in intestinal endothelial cells will change the histological structure of the intestinal epithelium.

XBP1- inhibition will exhibit impaired Paneth Cells, which leads to dysbiosis and spontaneous intestinal inflammation which may induce activation of NF-kB pathway which can lead to inflammation, anxiety, chronic depression, insulin and leptin resistance, it increases risk of cardiovascular disease and high TH17 levels which can lead to psoriasis or lupus, Many who have intersitial cystitis have high TH17 levels. It can cause bone lose and Alzheimers. On the other end of the scale not enough NF-kB can produce many health problems. Like lower cognitive function, inhibited ability to heal, inhibited nerve growth and brain plasticity. This is a good article covering it in more detail. https://www.selfhacked.com/blog/nuclear-factor-kappa-b/

The second gene that can increase risk of inflammatory bowel disease is oromucoid-like3 (ORMDL3). Over expression can lead to immune/inflammatory diseases. It has been linked to childhood asthma. Over expression causes inhibited calcium buffering capacity of the mitochondria. This can disrupt endocytosis, enzyme control , cell growth and proliferation and cell apoptosis. ORMDL3 takes part in protein folding and in regulating UPR. It is believed ERs induced inflammation in paneth cells may disturb ORMDL3 levels leading to inflammation.

TREM1 (Triggering Receptor Expressed On Myeloid Cells-1) inhibits autophagy and increases ERs stress levels. This has been shown to increase the severity of inflammatory bowel diseases. Defective autophagy in the endoplasmic reticulum can predispose someone to inflammatory bowel diseases form a decreased clearance of IRE1 during ERs. High IRE1 levels impairs insulin signaling this can lead to many metabolic diseases. TREM1 can either increase inflammation or decrease it. During infection TREM1 increases inflammation. TREM1 also interacts with other inflammatory pathways which can also result in TREM1 increasing inflammation. TREM1 is high during septic shock. Sustained increased levels of TREM1 can lead to inflammatory bowel disease, cardiovascular disease and atherosclerosis. TREM1 is needed to help clear infection. Unfortunately when an infection that contains OspA protein that are difficult for the body to clear like HIV and Borellia (Lyme Disease) it can cause TREM1 levels to remain high. This is why it is very important to work on reducing inflammation and address infection. Most infectious diseases there are no test for and the test they do have has a high failure rate at detecting the microbe responsible for the illness. But the body and what genes are effected and cytokines present can indicate when there is an infectious agent present. The more difficult infections can be killed but it takes a multilevel approach because most that carry the OspA take multiple forms and have to be addressed differently for each form it has taken.

Inflammatory bowel disease have been shown to have a dis-regulation of T Cell which can be induced by toxins, drugs, vaccine injury, farm chemical or processed foods.

Autophagy is a conserved lysosome-dependent catabolic process involved in degrading and recycling aggregates as well as damaged organelles. Enhancement of autophagy promotes the survival of various cells including intestinal endothelial cells, and nuetrophils by protecting them from microbial toxins. A disturbance in autophagy could disturb the function of intestinal endothelial cells and influence inflammatory response, immune response, ROS levels and endoplasmic reticulum stress. This can lead to inflammatory bowel diseases. Autophagy plays a vital role in alleviating of intestinal inflammtion, degredation of damage associated molecular patterns (DAMPS), which can help prevent inflammatory bowel diseases. PAMPs refer to various kinds of endogenous materials produced by stress, impaired or dying cells covering DNA, RNA, ATP, histones, hyaluronan, uric acid, heparin sulfate, the S100A calgranulins, IL-1, HSP, and chromatin-associated high motility box1(HMGB1).

Basal autopaghy occurs in nearly every cell to maintain homeostasis of the ammino acid pools. There are three types of autophagy.

Macropahy – targets material such as cytoplasmic components or invasive bactria which are surrounded by a double-membrane bound autophagosome.

Autophagosome when combined with lysosomechanges into a single-layer membrane autolysome with a strong degradative and digestive ability.

Microautophagy – during the process of microautophagy lysosomal/vacuolar membranes invaginate (fold in on itself) to engulf intracellular components via a non-selective degradative mechanism.

Chaperone-mediated autophagy transports organelles and proteins into lysosomes only with the assistance of chaperones which are located in lysosomal lumen. Chaperons are proteins that assist in convalent folding or unfolding and the assembly or disassembly of other macromolecular structures. They assist in the assembly of nucleosomes which are basic units of DNA.

Two steps of Autophagy.

The first step of autophagy cup-shaped double membrane phagophores are shaped in the cytoplasma of the cell, and then misfolded proteins, damaged organelles or bacteria are engulfed to become sperical double membraned autophagosomes. Autophagosomes are usually considered to be produced from the nucleation and membrane expansion of phagophores.

During the second step autophgosomes fuse with lysosomes and endosomes to form a single-lipid layer autolysome, which is regard as basal units for degradation and digestion. Autophagy process is induced by the detection of various specific cues such as starvation or invasion by pathogens.

Two proteins are known to participate in autophagy which include Mammaian Target of Rapamycin (mTOR) as an inhibitor and adenosine monophosphate activated protein kinase as an indicator. mTOR is often activated by lower levels of Adenosine Triphosphate (ATP) caused by nutrient sufficiency or several growth factor stimulations. mTORC1 inhibits autophagy in the presence of nutrients. mTORC1 regulates glycolysis, lipid biosynthesis, and the pentose phosphate pathway has been found to be under the control of mTORC1. mTORC1 mediates upregulation of SREBP-1 activity which is necessary for lipid biogenesis. mTORC1 increases mitochondrial DNA copy number and as well as encoding many genes involved in oxidative metablolism. It has been found that mTORC1 promotes transcriptional activity of PPARy coactivator (PCG-1a) which is usually low in those who have inflammatory bowel diseases. This leads to the inability to break down fats and cholesterol causing many health problems because lipids are needed by almost all cells of the body especially the digestive system to maintain proper function and health. Ironically mTORC1 inhibition leads to longer lifespan. mTORC1 inhibits autophagy. mTORC1 increases NRF2 activity the master regulator of the antioxidant system.

Excess mTORC1 activation can cause endoplasmic reticulum stress and excess ROS production.

Low ATP levels inhibits mTORC1. Inhibiting mTORC1 increases glucose uptake. Hypoxia (oxygen deprivation) inhibit mTORC1. Amino Acid deprivation can inhibit the citric acid cycle (TCA cycle) this also inhibits mTORC1. The body inhibits mTORC1 when it senses DNA damage. Autophagy reactivates mTORC1 whose activity then promotes the replacement of lysosomes consumed during autophagy.

Symptoms of excess mTORC1 . Since there is no information on what excess mTORC1 does I will have list the symptoms of inhibited autophagy and high ROS levels since those are issues caused by high mTORC1 levels.

Symptoms of inhibited autophagy. Nuerological problem , inhibited autophagy can lead to inflammation in the brain, mental illness. Mitochondrial dysfunction, decreased antioxidant function which can lead to high levels of ROS. Pancreatic inflammation. Fat accumulation throughout the body and can lead to fatty liver disease. Issues with lysosomal storage, diabetes and sickle cell anemia. Frequent illness from infectious agents.

Symptoms of high ROS. ROS is needed for redox signaling but becomes damaging if levels get too high. High levels of ROS cause inflammation. Leaky gut and can cause a leaky blood brain barrier. This also can lead to nuerological damage and brain inflammation causing mental illness. Can cause liver damage resulting in a hepatic liver. Fatigue from reduced energy levels. Mitochondrial dysfunction which can lead to MS. Here is a link to a good article on oxidative stress.

https://www.selfhacked.com/blog/oxidative-stress-101/

Things that stimulate mTORC1. Resistance training, amino acid L-Luecine, Beta Hydroxy Beta-methylbutyric acid which is a precursor of butyric acid. High intake of Iron stimulates mTORC1.

Inhibitors of mTORC1 are green tea, resveratrol, curcumin, caffeine and alcohol. Iron deficiency inhibits mTORC1. Green tea can damage the liver if taken for too long and curcumin chelates iron so can make a person anemic if consumed too long.

VDR

Vitamin D receptor (VDR) mediates the activities of vitamin D3 which is the activated form of vitamin D. A deficiency can effect our digestive system in many ways. The VDR is involved in regulating 33% of the genes in the body so problems with it can effect many things. VDR and Retinoid X receptor interact to with each other and can activate each other so issues with either one can effect vitamin D homeostasis. Inhibited VDR effects calcium homeostasis, electrolyte balance, and blood pressure.

Vitamin D3 acts as a hormone a hormone and helps regulate innate and adaptive immune responses. Those with low vitamin D levels or inhibited VDR receptor are prone to infection with Mycoplasma Tuberculosis. VDR is involved in producing the antimicrobial peptide/IL-37, defensin beta B, CLDN2 encoding claudin 2 and ATG16L1 related autophagy which protects us from inefection.

The VDR receptor is involved in gut microbiome balance and autophagy. Autophagy is the house keeper of our cells it helps clean them out, protect them from infection and helps to prevent misfolded proteins. Inhibited vitamin D receptor can cause inhibited bile flow and a decrease in LDL and increase in HDL. The reduced LDL causes bile to become sludgy which leads to biliary issues and gallbladder problems and can result in gall stones and biliary blockage.

When the VDR receptor is inhibited or there is a vitamin D deficiency we can develop inflammatory bowel diseases. IKBa is an inhibitor of pro-inflammatory NF-kB.

VDR inhibition or vitamin D deficiency alters the composition of intestinal microbiome. Butyrate producing bacteria become less numerous. Butyrate increases expression of VDR so a deficiency in Butyrate would further add to the inhibition of the VDR receptor. Butyrate also suppresses intestinal inflammation and enhances AMPs. AMPs help protect us from infection.

Toxins, mold toxins, infection and a lack of nutrients can inhibit the vitamin D receptor. High levels of vitamin D3 indicates the body has recognized an infection and is trying to fight it.

Farm chemicals especially glyphosate and glufonisate inhibit the vitamin D receptor. Many toxins found in processed food can also inhibit the vitamin D receptor.

Symptoms of inhibited VDR.

If the VDR is inhibited a person may experience problems with methyl donors and low dopamine levels. They may experience frequent infections and be low in GcMAF. Inhibited VDR can cause bone loss, hair loss, brain fog, increased TH17 levels resulting in lupus, psoriasis and/or skin rashes, tooth decay and poor oral health, inflammation throughout the body, can lead to high blood pressure. Low LDL which inhibits bile production resulting in biliary and gall bladder problems and can lead to stone formation. Electrolyte imbalance and iron deficiency. Low dopamine and GABA levels is a result of VDR inhibition. Prolactin level become low when VDR is inhibited. Gut dysbiosis and inflammation in the digestive system. Increased creatine and albumin levels and decreased alkaline phosphatase are symptoms of low vitamin D or inhibited vitamin D receptor. VDR inhibition or vitamin D deficiency can result in mast sell activation syndrome. CYP3a4 an enzyme needed for detoxing xenobiotics and drugs becomes inhibited. Hormonal imbalance is also a result of VDR inhibition. Hashimoto’s syndrome can result from VDR inhibition. Heart disease can be a result of VDR receptor inhibition or vitamin D deficiency. In more severe cases VDR inhibition can lead to liver and kidney disease.

Symptoms of Vitamin D deficiency.

Joint stiffness or pain, back aches, tooth decay, bleeding gums or gum disease, muscle cramps, hair loss, bone loss, weakening of bones, increases risk for cancer, sleep apnea, brain fog, fatigue, depression, leaky gut, excess sweating especially in the head area.

Excess vitamin D can lead to many health problems and can result in loss of bone from a disruption in the mechanisms that control calcium homeostasis. Though it is needed for calcium absorption high doses can have the opposite effects. High levels of vitamin D can lead to oxalate formation. Many studies show anything over 5000 IU a day can lead to oxalate formation and many health problems.The recommended daily allowance of vitamin D is 600 IU. It is best to get vitamin D from food sources. Exposure to sunlight, far infrared, halogen lights can increase the bodies production of vitamin D. Short term raised levels have been found to be beneficial but long term raised vitamin D levels have been found to be harmful to our health. High levels of vitamin D can contribute to the inhibition of the VDR. Excess vitamin D can result in high levels of calcium in the blood resulting in calcium deposits forming in the organs including the lungs.

Sources of vitamin D. Sunlight, halogen lights, far infrared light increases the bodies production of vitamin D. Excess sunlight has been shown to cause high levels of vitamin D and is why life guards have some of the highest rates of kidney stones. Fish oil contains vitamin D. Sardine , salmon and cod liver oil are good sources. I try to make sure the fish is not from contaminated areas. Most sea food is high in vitamin D. Mushrooms and eggs are a good source of vitamin D. Animal liver is another good source of vitamin D. Cestrum Diurnum, Waxy leaf nightshade (solanum glaucophyllum), yellow oat grass (trisetum flavescens) are plant sources of vitamin D. Those plants are so high in vitamin C that they cause calcinosis in grazing animals. Brown and read seaweed are also sources of vitamin D and cholesterol. Mercury found in fish is for the most part only a problem if we have leaky gut. When the gut is intact only about 5% of the toxins like mercury get absorbed that have been consumed and when healthy the body can easily detox that amount unless it is shot directly into the blood stream. I mention this because even though they claim vaccines do not contain mercury some still do.

Things needed for the body to be able to use vitamin D. Vitamin K2, Vitamin A, zinc, sulfur is needed to sulfate vitamin D so sulfation issues need to be addressed. Magnesium increases the bodies response to vitamin D. Boron increases vitamin D in the blood stream. Water is needed, dehydration inhibits many receptors in the body. Silica helps improve the function of many receptors in the body. Sunlight helps to sulfate nutrients. DAO and lysine are also needed to sulfate vitamin D. Boron is touchy, low levels reduce estrogen high levels increases estrogen.

Things that enhance vitamin D receptor activity. Parathyroid hormone, Sirt 1, Dopamine, Omega 3 , Omega 6, Phytoestrogens, Testosterone, Postaglandulins and bile activates VDR. Bitter herbs stimulate bile production. Even if you do not swallow bitter herbs just tasting them stimulates bile production. Resveratrol activates the vitamin D receptor. Querciten enhances vitamin D receptor activity. Curcumin stimulates the vitamin D receptor but if taken for too long it can lead to anemia because it chelates iron from the body. So one may use it at first to help stimulate the VDR receptor but probably should just take maintenance doses to make sure it continues to function. Human Growth Hormone stimulates the vitamin D receptor. Sleep, fasting, and strength training increase HGH.

Things that can inhibit VDR are cortisol/glucocorticoids, high prolactin levels, imbalance in thyroid hormones, TGF-Beta, phosphatonins which regulate phosphate homeostasis, and ubiquitin can inhibit VDR. Many of these things are inhbited by autophagy which would prevent them from inhibiting the VDR receptor. Caffeine can also inhibit the VDR. High TGF-B levels can be an indication of T cell imbalance and/or B cell imblance. Probiotics that reduce inflammatin and increase T regulatory cells should reduce TGF-B. High phosphatonins is a sign of low klotho levels. Exercise increases klotho, Most Acidophilus bacteria and Lactobacillus Lactis increases klotho. Cordyceps mushrooms increase kltoho. PPAR Gamma activators stimulate klothos, Some PPAR gamma activators are berberine, magnolia, and Omega 3s. Those who are obese should not stimulate PPAR gamma because they are usually PPAR gamma dominant. Adaptogenic herbs like suma root and maca root can help normalize adrenal levels. Ubiquitin levels are reduced by autophagy. High prolactin levels can result from toxins in plastic containers used to store food and some farm chemicals found in our food supply. There are also chemicals in processed foods that can cause high prolactin levels. Those who are taking drugs should not use berberine or things that contain it because it inhibits the cytochrome P450 enzymes needed to detox medications.

Fulvic acid and nobiline induce autophagy. We do not want to overstimulate autophagy. Fasting also stimulates autophagy but those who are Type1 diabetics have to be careful fasting can induce ketoacidosis in them. Branch Chain fatty acids can inhibit autophagy. Tumeric, ginger, berberine, gensing, mushrooms and elderberries can stimulate autophagy.

NOD2 – Nucleotidebinding Oligomerization Domaincontaining Protein 2 whew that was a lot. A member of the NLP family which is a group of immune regulating proteins. It is a sensor of muramyl dipeptide which is a constituent of both gram negative and gram positive bacteria. It is found in macropages and paneth cells. When inhibited a-defensin numbers are decreased, lower sensitivity to bacteria infection, and altered immune function from Toll Like Receptors becoming suppressed. This results in the inability to clear bacteria infections from the intestines. Inate and adaptive immunity is impaired. Nod2 induces autophagy through the NOD2 pathway. NOD2 is induced by NLP or bacteria infection, this promotes the delivery of NOD2 which enhances inflammation. Showing that if You have high NOD2 levels you would not want to induce autophagy. NOD2 prevents infection in cells which is mediated by ROS and MAPK pathways. NOD2 altered expression can lead to inflammatory bowel disease. Many cellular proteins interact with NOD2 directly and regulate it’s function positively or negatively. Among these proteins is Erbin. Erbin regulates Erbb2 if Erbin is inhibited Erbb2 levels can go up resulting in cancer growth. Centaurin B1 which I have no idea what it’s function is. Angio-associated migratory protein which is involved in endothelial tube formation and endothelial cell migration. It is involved in angiogenesis. Carbamoyl-phosphate synthase 2 is involved in the production of nucelotides in cells. Mitogen-activated protein 1 which helps down regulate NOD2. Heat shock protein 90 interacts with NOD2. HSP90 is involved in folding , intracellular transport and the degradation and maintenance of proteins. I have post on heat shock proteins like HSP90 and HSP70.

NOD deficiency. NOD2 is involved in maintaining balance between the microbiome and immune response. NOD2 deficiency results in loss of epithelium integrity, and increased susceptibility to intestinal inflammation. NOD2 deficiency can cause dysfunction in intestinal paneth and goblet cells. Deficiency increases IFN-y, and decrease ROS production which protects from infection so we need a balance because excess ROS can damage tissues in the body.

NOD2 upregulation. Vitamin D supplementation has been shown to increase NOD2 which helps to fight infection. Excess NOD2 can lead to rheumatoid arthritis, and systematic inflammation. Excess NOD2 has been linked to cardiovascular disease and pulmonary disease. NOD2 prevents inflammation in the eyes.

NOD2 deficiency causes low TH17 levels, inhibited immunity, and will be more prone to cancer. NOD2 is also involved in the detection and eradication of viruses.

Excess NOD2 causes systematic inflammation and sarcoidosis. Often times it is mistaken for cancer or copd. High NOD2 levels is a sign of infection.

Damage to the mucus membrane and intestinal tissue can cause it’s dis-regulation. This shows the importance of restoring mucus membrane and work on healing the gut.

Atg16L1

Autophagy-Related Protein 16-like Protein 1 – Deficiency in Atg16L1 impairs recruitment of Atg12-Atg-5 complex which impairs the engulfment of pathogens and cellular organelles during the process of autophagic catabolism. Atg16L1 defeciency cause Paneth cell dysfunction and increases inflammation. Atg16L1 causes high leptin and adiponectin levels. A deficiency in Atg16L1 leads to intestinal lesions. Leptin tells the brain we do not need to eat. Leptin increases inflammation in the body. High leptin levels lead to chronic fatigue. Leptin can cause Th1 dominance. Those with high IL-10 levels would want to avoid probiotics that increase IL-10 because leptin increases IL-10. Leptin causes mast cells to become more inflammatory. Leptin causes lower T regulatory cells which keep our immune system at homeostasis. Leptin can cause excess blood clotting (throbosis). Leptin can cause high blood pressure. Leptin increases estrogen levels. Adiponectin is a protein hormone involved in glucose levels and fatty acid breakdown. High adiponectin levels causes a loss of appetite it causes weight loss and works synergistically with leptin. Adiponecton decreases gluconeogenesis. It increases B-oxidation of fats. It protects against endothelial dysfunction. It increases insulin sensitivity. So you can see the importance of Atg16L1 homeostasis.

Mir223 restores autophagy and Atg16L1 homeostasis. Mir233 downregulates inflammation. Mir233 is reduced in sepsis. Mir233 increase HDL cholesterol levels. But Mir233 is upregulated in inflammatory bowel diseases. Increasing Claudin-8 inhibits Mir233 inflammatory effects.

ROS (Reactive Oxygen Species)

ROS or Reactive Oxygen Species modulates cellular function under normal conditions. ROS is produced during the process of oxidative phosphorylation and can be handled by instracellular antioxidants. Injury, toxins , vaccine injury, infection, and stress can cause an over production of ROS which can exceed the generation of antioxidants leading to oxidative stress which can cause a lot of damage throughout the body. It causes inflammation, cell damage and even cell death. When the mitochondria become dysfunctional this can cause a rearrangement of the cytoskeleton which is framework of the plasma membrane and effects the balance between kinases, and phosphatases which promotes the ability of microorganisms to enter the cell and contributes to many inflammatory diseases. Excess ROS increases the permeability of intestinal epithelial. When levels of ROS are normal it will induce autophagy and microphagy which reduces inflammation. Reducing ROS levels too low can have the opposite effect because it would prevent it from inducing autophagy and we would lose the protection it gives us from infection.

Antioxidants can reduce oxidative stress but when homeostasis is achieved a person should only take maintenance doses. Over use of antioxidants can promote cancer by protecting it from apoptosis it also increases our risk of infection by reducing ROS levels too low.

Xenophagy

Xenophagy is the clearance of pathogens regulated by autophagy. Reduces Xenophagy leads to alterations of intestinal microbiota. This leads to a higher rate of infection. The microbiotia induce xenophagy in basal paneth cells which is induced by INF-y to maintain intestinal integrity. This impairs sensing of intracellular micro organisms in the intestinal endothelial cells and contributes to the progression of inflammatory bowel disease. Showing the importance on healing the intestinal tract so that the mucus membrane can be restored. Prebiotic fiber and the tryptophan metabolizing gut microbiota increases IFN-y. The commensal strains of E Coli increases IFN-y. Lactobacillus Gasseri increases IFN-y. Bacteroides Fragilis increases IFN-y and has been found to protect from many types of infections. Butyric Acid must be present to maintain IFN-y homeostasis. So it would also be a good idea to make sure the butyrate producing microbes are established.

IRGM (Immunity Related GTPase Family M protein) – is involved in killing of bacteria, vacuolar trafficking and acidification, it is also involved in autophagy. It is involved in fighting mycoplasmas. Damage to the digestive tract can impair it’s function which wold make you susceptible to mycoplasma infection. Inflammation inhibits IRGM. Our digestive tract needs to be acidic. If it becomes to alkaline then it creates an environment that promotes infection and dysbiosis and we lose our commensal microbiota.

True cause of illness and things that may help.

This is not medical advice I am posting this for educational and informational purposes.

 

 

I have a lot more to add to this but need a break and then I will finish it. I am going to add the things that negatively impact health and how it happens. Some of it I have covered but I have not covered the how part of it I only covered things that may help correct it.

Because probiotics can cause sepsis if you have ulcers or your gut is too porous I consumed a lot of mucilage and took bismuth in order to make sure my gut healed enough that would not happen.

To fully grasp the information here and to grasp the information in the links you will need to understand that Germ Theory and Terrain Theory have been proven wrong and that is why our Facebook group Synergistic Health decided we need a new theory “Enviroment and Biome Theory of Health”

https://iamajuicer.wordpress.com/2018/08/18/germ-theory-and-terrain-theory-are-wrong/

 

This article discusses how our microbiome effect the whole body even the blood brain barrier.

In this post I am going to try and show how our environment, biome of our environment and our won biome effect our health. This shows that our Facebook group Synergistic Health is correct with our theory “Environment and Biome Theory of Health” is correct and that germ theory and terrain theory are incorrect. Learning this will help people understand why their genes have very little impact on their health compared to the above mentioned things. I also list the things that may be able to correct them.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102499/

In all the research I have read gut diversity increases health and longevity and is found to be a commonality in centurions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051225/

There is a myth we should alkaize our digestive system must be acidic and alkalinity cause pathogenic and hydrogen sulfide producing bacteria to increase. This causes sulfation issues and increased ammonia getting the body stuck in a cycle. Bile and digestive enzymes become inhibited which cause high estrogen levels and copper will become biounavailable. You must break this cycle by getting ammonia levels down. BH4 levels get low when this happens eating protein increases ammonia levels. Short chain fatty acids balance our T cells so it is important to increase SCFA producing bacteria. I did a blog post on reducing ammonia levels (alkalosis). I did a post on reducing akalosis. I also did a summary of my notes which covers many of these things. If you search for akalosis and summary you should be able to find the information.

Fiber especially inulin increases the good gut bacteria. Exercise also increases our good gut bacteria. Reducing stress or learning to deal with stress increases our good gut bacteria. Ghee is high in butyrate which increases our good gut bacteria.

Egg and milk allergies indicate high Staphylococcus Aureus levels. This is caused by low microbiota that breaks up biofilms and produces natural antibiotics. This can also be caused by low lactobacillus paracasei, lactobacillus adolenscentis and lactobacillus rhamnosis levels.

I do not mention the strains that produce histamines because they are usually not a problem unless something is wrong in the body and they are needed for gut and body health. Avoiding the foods that cause them to produce histamines is more effective. Fermented foods, and aged meats and many cheeses will cause them to produce histamines. Some cheeses like Gouda and Parmesion have species of microbes that reduce histamines. This is why overconsumption of them can cause constipation because histamine stimulates stomache acid production. Those with low stomach acid production may benefit from eating foods that increase histamines.

An imbalance in our gut bacteria can lead to the production of high substance P levels which leads to systematic inflammation. If levels get high enough a person will start to lose their hair, they will get burning in their skin especially at night. The burning mostly occurs in the scalp and down the spine. I posted on how to reduce substance P.

When replacing a microbe you may be lacking it is normal to experience cramps and bloating until they get established. Taking the same probiotic daily can cause gut dysbiosis which is as bad as when candida goes pathogenic and can cause candida and H Pylori to switch from commensal to pathogenic. Probiotics should be alternated and one should take a break from them to let the microbial community balance out.

Most Bifidobacterium and Lactobacillus have some oxalate degrading abilities. The microbiota that produce vitamin B12 need chromium to be present to produce it.

Exercise increases our good gut bacteria. Stress and trauma increase our bad bacteria so it is very important to learn to meditate , pray and not to dwell on things you can do nothing about and do your best to get over trauma and do not hold grudges or be resentful or hateful. When we have a lot of negative emotions it increases the gut bacteria that increases adrenaline and it can tax our adrenals.

Diets rich on complex carbohydrates have been shown to prevent infection from food born pathogens. Processed sugar has been found to dramatically increase risk of infection from ford born pathogens.

Often times a persons microbiome is influenced by their sexual partners. Their sexual partner may have different metabolic factors so could appear to be unaffected. Usually a person sexual partner should be treated for dysbiosis or infection also to prevent constant reinfection or constant microbiome disruption.

Galacto-oligosaccharides increase absorption of nutrients, and increase the beneficial bacteria that are important in health mental health and cognition. It prevents constipation and helps protect from food born pathogens. It increases the microbiome that reduces anxiety and pain. It is derived from raw milk and is destroyed during pasteurizing. It also decreases the risk of pulmonary infections. It reduces almost all inflammatory markers in the body. It reduces intestinal inflammation. Galacto-oligosaccharid and fructo-oligosaccharid helps to prevent diabetes.

Our bodies secrete FUT2 to modulate our immune system and to keep our good microbiome health. Many things can make us deficient in FUT2 enzymes which causes a loss of our good gut microbiome and can lead to inflammatory bowel diseases and gut dysbiosis. Fructooligosaccharide and oligosaccharides can replace FUT2 until it is corrected. This is can also result from a deficiency in the microbiota that stimulate IL-22

A loss of our gut microbiome can cause raised zonulin levels which results in many food intolerances, metabolic issues , increase susceptibility to infection and if not corrected can lead to acidosis or alkalosis. Zonulin regulates gut permeability if levels get too low we can develop malabsorption issues. If zonulin levels get to high we can develop many health problems. It can also lead to interstitial cystitis and damage the blood brain barrier which results in the loss of protection of the brain and can lead to infection , encephalopathy and even chira which is a life threatening condition. Increased zonulin levels causes depression, anxiety and can even cause paranoid delusions and psychosis. Mold toxins can increase zonulin levels. BT Toxin found in GMO increase zonulin levels. Farm chemicals which are found to be heavy in our food increases zonulin levels especially glyphosate and glufosinate. It is very important to eat organic when possible. A diet high in fiber and resistant starches increases the microbes that reduce zonulin. Oddly our sterile lifestyles have caused a loss of the microbes that keep zonulin levels balanced. They have found those who are in nature and work with the soil a lot get the good microbes that keep zonulin levels balanced. Unfortunately glyphosate and glufosinate are killing those microbes in the soil which is making it more and more difficult for a person to get those microbes. Endotoxins and mycotoxins increase zonulin levels making us more prone to leaky gut. Leaky gut causes systematic inflammation which can lead to autoimmunity. Butyrate producing gut bacteria reduce zonulin levels helping to prevent leaky gut. Butter and raw milk is high in butyrate. Inflammation causes increased zonulin levels so microbes that reduce inflammation will decrease zonulin. When zonulin levels are how toxins the body would not absorb but would get excreted are easily absorbed which causes high heavy metal and other toxins levels in the body. High zonulin levels also result in food particles entering the blood stream which causes a lot of food sensitivities. This can be corrected by addressing the leaky gut. When zonulin levels are high it increases mast cell degranulation which can lead to mast cell activation syndrome or mastocytosis. This increases histamines leading to autoimmunity and allergies. This also will correct itself once zonulin levels are reduce. Those with high zonulin levels should avoid gluten and gliaden until it is corrected because they raise zonulin levels. High zonulin and high inflammation levels has been linked to just about all types of chronic illness. Inflammation can cause high zonulin levels, high zonulin levels can lead to inflammation creating a cycle that is difficult to break. Inflammation disables the immune system and is why so many illnesses like tick born illness, candida and many other infections are becoming epidemic. Almost all illness can be link to zonulin.

https://www.sciencedirect.com/science/article/pii/S2352551717300288

https://www.physiology.org/doi/full/10.1152/physrev.00003.2008

https://www.frontiersin.org/articles/10.3389/fmicb.2017.01936/full

https://www.tandfonline.com/doi/pdf/10.1080/21688370.2016.1251384

Our gut microbiome regulate our zonulin levels which regulates the tight junction layer. When zonulin is high then we develop leaky gut which causes chronic illness and even effects our brains. Our gut bacteria even regulate our HPA axis. Microbes that increase IL-10, T regulatory cells and reduce inflammation will reduce zonulin levels which will restore the tight junction protein layer. Also stress increases zonulin so microbes that reduce stress will also decrease zonulin levels.

https://www.tandfonline.com/doi/pdf/10.1080/21688370.2016.1251384

https://link.springer.com/article/10.1007/s00394-018-1784-0

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288588/

Our sterile lives have added to the increase in zonulin levels. Also nutrient deficiencies cause by over farming land and chemicals like glyphosate and glufosinate that chelate nutrients are causing nutrient deficiencies which increases zonulin. This indicates the the biome of our environment is also important for our health. It also indicates that our environment itself can influence our health.

http://www.pnas.org/content/106/39/16799.long

Nutrient deficiencies also stimulate zonulin and so do bad fats and excessive meat consumption. Excess vitamin B12 increases zonulin levels. I do not supplement with it, I nurture my gut microbiota that produce it and I make sure I get cobalt which they need to produce B12. On the other end of the scale zonulin deficiency can result in the inability to absorb nutrients. This shows the importance of learning to achieve homeostasis. I cannot find studies showing that inhibited zonulin causes malabsorption but I have noticed those who have high levels of the bacteria that inhibit zonulin and low levels of the ones that stimulate zonulin have malabsorption issues.

https://www.sciencedirect.com/science/article/pii/S0041134514008045

High zonulin levels can lead to decreased intestinal motility which causes the food to sit in the digestive tract and ferment instead of digesting. This increases the ammonia, hydrogen, sulfide and methane producing microbes which raises zonulin levels even higher. If I ever get a chance to write a book I will cover it in more detail. Once this cycle starts it is very hard to break and a person will not be able to absorb nutrients because their food is not getting broken down properly.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111132#s4

So all this being said the bigger the variety of gut microbes we have the more balanced our zonulin becomes.

Butyrate producing microbiota increase TGF-B which is needed to prevent some commensals from becoming harmful. A deficiency in TGF-B can lead to inflammatory bowel disease which can cause bile to be inhibited. The most important of these are F Prausnitzii, Clostridium Leptum, Eubacterium Rectale and Roseburia. If deficient in IL-10 or TGF-B the microbiota that stimulates bile will become pathogenic in nature IL-10 and TGF-B work together to keep them in check so they continue to function properly. I discuss bile in more detail at the end of this article.

https://link.springer.com/article/10.1007/s00535-017-1350-1

https://www.tandfonline.com/doi/full/10.3109/0284186X.2015.1054949

Raw potatoes, inulin, chickpeas and other legumes feed the gut bacteria that prevent gliaden and gluten intolerance. Too much of these can increase the glucose levels in the blood. That may be good for those with malabsorption but high glucose levels can lead to cancer and other health problems.

Increased CB1 receptor activation causes leaky gut which can lead to food intolerances from our gut becoming too porous. This can lead to increased LPS levels which can lead to endotoxemia and sepsis. Increased zonulin also does this. Stress increases zonulin.

The PH of the gut and bladder should be between 4 to 5. The lower the number the more acidic the high the number the more alkaline. We do not want alkaline it causes infection and gut dysbiosis. Candida and H Pylori will go from commensal to pathogenic.

Bloating can be from taking too much of a certain probiotic which can lead to dysbiosis , inflammation, ulcerations, or high histamines. High histamines will cause acid reflux. Low histamine inhibits bile and will cause bile reflux constipation and low stomach acid production. If you have low histamines fermented foods will increase the histamine producing bacteria but be cautious do not increase them too far. We can also become bloated if candid or H Pylori go from commensal to pathogenic.

Increased gut permeability (leaky gut) can lead to bone loss, autoimmunity, and many metabolic issues.

Our gut bacteria need carbohydrates but many avoid them. There are good carbs and bad carbs.

A microbiotia accessable carbohydrate diet increases beneficial bacteria that produce short chain fatty acid. This consist of fiber and carbohydrates. This increases the bacteria that produce short chain fatty acids. If we do not produce enough SCFA we will become constipated and bile production will become inhibited. This will also happen if we develop malabsorption from having high bacteroidetes, methane producing and sulfur digesting bacteria. They contribute to malabsorption, constipation and inhibited bile production from a lack of SCFA in the body. Our blood glucose levels will also become very low and we may develop high insulin levels. Clostridium infection is also a major cause of this and indicates we are lacking the microbiota that protect us from it. This can cause a cycle that is hard to break because bile is needed to prevent clostridium infection.

High histamines usually indicates low bifidobacterium levels. Bifidobacterium degrade histamines. Low Bifidobacterium can cause weight gain in some people and can lead to anxiety, difficulty sleeping and difficulty concentrating. Our histamine degrading bacteria need vitamins A,C, E and Zinc. Bifidobacterium which there are many species produce folate. Most Bifidobacterium increases IgA which prevents food intolerances and allergies. Bifidobacterium also break down gliaden. Excess gliaden can raise zonulin levels leading to the tight junction layer becoming more permeable resulting in leaky gut.

Lactobacillus needs vitamin A and consuming it has been shown to restore lactobacillus. Most lactobacillus prevent candida and fungus infections. Most Lactobacillus prevent lung infection. Most Lactobacillus increase IL-10. IL-10 is needed for commensalism. Those deficient in Lactobacillus will be extremely underweight.

https://pdfs.semanticscholar.org/b2c3/c191fc3c8efbd745d5583d6be940a4dcae06.pdf

Most probiotics should be taken with an oligosaccharide. They help feed them and get them established. Pectin also protects the good bacteria helping it to thrive. Olive oil has been found to prevent them from making TMAO. If TMAO levels get too high we can develop a fish like smell, diabetes and/or cardiovascular disease.

Lactobacillus Reuteri increases oxytocin which helps keep us calm and helps prevent depression. It also helps prevent diarrhea. It increases intestinal absorption of nutrients. It prevents cavities and promotes dental health. It protects against pathogens and parasites. It has been shown to help with autism. L Reuteri produces food need by most of the other commensal bacteria. It requires sugar to produce the food the commensal microbes need. L reuteri also help prevent asthma. Helps restore normal vaginal and bladder microbiome. If you are sensitive to sugars and starches it could be an indication you are deficient in L Reuteri. L Reuteri breaks down sugars and starches. A deficiency in Lactobacillus Reuteri can also contribute to milk allergy and a lower resistance to pain. It prevents gingivitis and periodontal disease. It helps keep H Pylori commensal. L Reuteri improves the production of bile.

Clostrium Leptum has been found to be low in those with inflammatory bowel disease and Chohn’s disease. It breaks down carbohydrates and produces butyrate. It reduces inflammation.

I believe L Reuteri and L Fermentum are the same species. Often times research papers state that they are the same species.

Lactobacillus Fermentum found in raw goats milk protects from urinary tract infection and food born pathogens. It has been shown to increase other lactobacillus bacteria. This would help those who have difficulty gaining weight. It is resistant to most antibiotics and has been found to transfer that ability to the other but microbes. This also would help with lactos intolerance. L Fermentum prevents skin rashes and eczema By increasing TH1. It prevents IgA related allergic disease. L fermentum helps prevent urinary infection. Low I IgA levels are common in inflammatory bowel disease and those who have malabsorption disorders. Reduces endotoxins. Helps protect from cavities and gingivitis.

Bacteroides Vulgatus increases bile production, if levels are low a person is susceptible to inflammatory bowel disease. If levels get too high a person will develop celiac disease. This occurs if a person is lacking the microbiotia that stimulate IL-10, SMAD3 and TGFB.

Pediococcus pentosaceus prevents clostridium infection of the digestive system by reducing zonulin. This would improve bile production. It also reduces inflammation. It produces natural antibiotics that fight bacteria.

Bacillus Coagulins prevents lactose intolerance. Helps break down food better increasing nutrient absorption. Helps prevent diarrhea. Prevents gas, bloating and intestinal inflammation. Helps prevent constipation. Reduces endotoxins. Improves bladder and vaginal health. Helps keep H Pylori commensal.

Bacillus Subtilis produces food needed by the other commensal microbes has been shown to balance the gut microbiome. It prevents gastrointestinal and urinary tract infection. It is found in soil. It stimulates IgM, and IgG which important part of immune function. Protects the DNA and has antioxidant properties. Helps prevent diabetes and cardiovascular disease. If it is supplied with lactulose which is found in raw milk but destroyed during pasteurization it will prevent constipation. It reduces inflammation and has been shown to reverse irritable bowel disease. It Balances our T cells which would prevent allergies and autoimmunity. It prevents H Pylori and Candida from becoming pathogenic. Reduces endotoxins and heals the liver and kidneys. It prevents skin rashes and lesions. It increases our ability to tolerate heat. Helps break down phytic acid preventing it from being and antinutrient. B Subtilis has been shown to reduce blood pressure and prevent atherosclerosis. B Subtilis communicates with the body to let is know what is going on. It kind of acts like a soldier and a nurse. It stimulates IFN-y in spleens of mammals which is an important part of the bodies ability to fight infections. Seems more important for fighting infection then dendric cells and natural killer cells. IFN-y prevent viruses from being able to adhere to cells. Increasing IFN-y increases CD8 molecules. Those who are TH1 dominant should avoid this strain it increases TH1.

https://iai.asm.org/content/75/3/1167

Lactobacillus sanfranciscensis helps degrade phytate preventing them from being and antinutrient. Decreases gut permeability and prevents obesity. Reduces symptoms of inflammatory bowel disease. It is found in raw sour bread dough.

Lactobacillus pentosus found in fermented olive products. It helps prevent food born pathogens. It helps break down carbohydrates. Helps reduce symptoms of lactose intolerance. It can break down a wide variety of sugars and carbohydrates.

Lactobacillus Salivarius reduces histamines. Protects the throat, mouth and nasal cavities from infection. It helps prevent cavities. They help keep the ph of the intestines balanced. It helps with nutrient absorption especially folate. It reduces nausea, bloating, cramping and inflammation in the digestive system. It protects us from food born pathogens. It protects us from getting strept throat and halitosis. It lowers cortisol levels and reduces stress and anxiety. L Slivarius increases endurance. Helps prevent lactose intolerance. It prevents flatulence. Has been shown to protect the pancreas. Has been shown to reverse dermatitis.

Oxabacter Formigenes reduces oxalates and reduces pain. It is the primary oxalate degrading bacteria in the gut.

Lactobacillus Paracasei inhibits infection and helps reduce ammonia producing bacteria. It is a subspecies of Lactobacillus Casei which has many of the same benefits. It also prevents anxiety but not depression. L paracasei especiall ssp Casei prevents obesity. L Casei reduces the duration of infections. L Paracasei helps prevent allergies. L paracasei and ssp L Casei should not be taken by those with high histamines. It prevents halitosis and cavities. It has been shown to protect the nasal cavities, mouth and throat from infection.

L Casei protects us from pathogens that cause diarrhea and antibiotic induced diarrhea. It improves colon health and inceases the commensal bacteria that help prevent depression and anxiety. Helps protect the gums from infection. Has been shown to protect the health of the pancreas. Increases IL-10 and TGF-B.

Lactobacillus Casei ssp shirota prevents constipation. Increases serotonin. It improves mood and prevents depression. It has the best long term effects at improving mood.

Lactobacillus Brevis prevents urinary and intestinal infection by regulating the PH of the digestive system and renal system. It helps keep it from getting too akaline. Lactobacillus Brevis improves cellular immunity it protects the gut from excess bile acids and keeps H Pylori commensal. It produces natural antibiotics that protect the gut from pathogens.

Streptococcus Thermophilus is needed by most of the gut bacteria to get established especially lactobacillus debrueckii. S Thermophilus helps with lactose intolerance. It prevents cavities and infection in the nose, throat and mouth. Helps prevent inflammatory bowel diseases. It accelerates healing in the gut.

Lactobacillus Debrueckii is needed to establish the commensal microbiome and to prevent C Diff infection. It also prevents inflammation. It is found in butter milk. It also helps keep H Pylori commensal. It helps degrade milk proteins. It also helps prevent liver disease. L Debrueckii also prevents fungus infection. It also prevents obesity.

lactobacillus Plantarum is needed to balance our gut bacteria which helps prevent dysbiosis. It also helps prevent diabetes. Helps prevent candida and fungus infections. Helps prevent inflammatory bowel diseases. It reduces HIV, enhances memory and reduces brain inflammation. Reduces abdominal pain.

Saccharomyces Boulardii helps prevent autoimmunity, protects from diarrhea caused by pathogens. Helps keep H Pylori commensal. Helps prevent inflammatory bowel. Saccharomyces Boulardii helps with gluten intolerance and reduces symptoms of SIBO.

Bifidobacterium bifidum helps in the production of many B vitamins. Prevents celiac diseas, milk allergies and many other food sensitivities. Reduces histamines. Improves immune function. Prevents ulcers and diarrhea. It is important for vaginal homeostasis. Has been shown to reduce symptoms of inflammatory bowel diseases. Prevents constipation and lung infection. Prevents pouchitis and infections in the lining of the intestines. Has been found to improve immune function. Prevents eczema. It also produces the B vitamins common to Bifidobacterium but also produces vitamin K2. It helps those who do not produce enough lactase because it breaks down lactose. Increases red blood cell production helping to prevent anemia. Has been shown to reduce the severity of the flu and common colds.

Bacillus Coagulans found in the soil , it improves bowel movements, helps with inflammatory bowel diseases, reduces bloating and pain in the digestive system. It also decrease the inflammatory C-reactive protein which is high during infection. It reduces intestinal gas. Reduces the risk of infection especially by influenza. Has been shown to reduce arthritis symptoms. It has been shown to help with gluten intolerance and allergies. It has been shown to reduce symptoms of SIBO. It has been shown to prevent food born pathogens. Is effective at fighting a broad range of pathogens. It reduces symptoms of arthritis if it has an adequate supply of inulin.

Saccharomyces Cerevisiae reduces oxidative stress and free radicals including hydroxy radicals and prevents excess nitric oxide production. Helps prevent iron toxicity. It stimulates the good inflammatory cytokines while inhibiting the bad ones. It helps in developing humoral immunity. Can reduce candida infection but if taken in excess will cause symptoms that are exactly the same as candida infection and is often times more common in those who are believed to have candida infections in the bladder. It helps those who have phenylketonuria or proteinuria it breaks down proteins like phenylalanine. Saccharomyces Cerevisiae prevents acne.

Lactobacillus gallinarum prevents urinary tract infection and reduces oxalates. It reduces symptoms of allergy. It helps break down phytic acid preventing it from being an antinutrient.

Bacillus Subtilis found in soil protects and heals intestinal epithial cells. It is improtant in the proper absorption of nutrients. If deficient in B Subtilis you will suffer from Malabsorption syndrome. It helps keep our T cells balanced. It is needed for digestion of carbohydrates. Has been shown to keep H Pylori commensal and fight food born illness. Has a broad range of antimicrobial properties.

Lactobacillus Helveticus is found in cheeses like parmesian, cheddar, swiss cheeses, buttermilk and cheddar cheese. Protects the gut health and is a butyrate producing bacteria. It reduces neurological inflammation and restores cognitive function. It helps prevent anxiety and depression. It improves sleep and prevents lung infection. It reduces parathyroid hormone and improves calcium metabolism. It improves learning and cognition. It fights candida and prevents dermatitis. It fights cancer and reduces inflammation. L Helviticus also prevents lung infections. It is and ACE inhibitor so prevents high blood pressure. It is important for whole body health and protects the liver and kidneys. It helps prevent lactose intolerance. It reduces anxiety and promotes the feeling of well being. It prevents mood swings and aggressive behavior. It helps prevent depression.

Bifidobacterium Longhum helps prevent anxiety and depression, and improves cognitive function, it helps prevent viral infections and symptoms of ulcerative colitis. B Infantis is a subspecies which has been shown to protect against polio. B Longhum protects the lungs from infection. It prevents food born illness and prevents candida from becoming pathogenic. It reduces symptoms of gout and prevents inflammation. It prevents allergies and celiac disease. It reduces endotoxins and prevents fatty liver disease. It increases biotin levels. It reduces bloating in the gut especially ssp Infantis. B Longhum improves sleep and prevents anxiety. Reduces depression caused by stress by reducing cortisol. It prevents liver disease and produces B12 and Folate.c It improves bone health and fights cancer. It decreases TH1 and TH17 cytokines. B Longhum also reduces aggressive behavior. B Longhum improves nutrient absorption. Reduces histamines. B longhum stimulates the vagal nerve.

B Infanis increases tryptophan. Decreases bloating. Bifidobacterium Longhum also helps prevent lactose intolerance. It detoxes serotonin metabolites. It decreases adrenalin levels and restores the HPA axis. It reduces inflammation and increases lifespan. It prevents ulcers. It helps prevent lactose intolerance. Increases IL-10 and IL-1B which seems contridicting but IL-1B is needed to increase intestinal motility. IL-10 keeps IL-1B from causing inflammation and immune issues.

Bifidobacterium Infantis increases tryptophan, serrotonin and GABA precursors. Helps prevent inflammatory bowel diseases. B Infantis increases T regulatory cells which helps keep the immune system balanced. B Infantis promotes the production of IgA which is usually low in those with malabsorption and inflammatory bowel disease.

B Infantis reduces histamines. B infantis decreases intestinal bloating, pain and gut distention (enlarged or inflammed). B Infantis increases tolerance to pain. B Infantis has been shown to protect the health of the pancreas.

Bifidobacterium Breve helps protect from food born pathogens and diarrhea. It also helps prevent allergies. Has been shown to improve intestinal health. Reduces anxiety and improves cognition. Reduces histamines. It helps the body absorb nutrients. It reduces bloating and inflammation. Prevents obesity.

Bacteroides Thetaiotaomicron secrete natural antibiotics which keep the gut balanced. It is also responsible for innate immunity in the intestines. It reinforces the mucous membrane. It reduces inflammation. It also helps break down carbohydrates. Prevents constipation and improves bile production. But high levels can promote Clostridium infection.

Bacteroides Ovatus helps break down carbohydrates and feeds other commensal bacteria. It breaks down the most difficult fiber that none of the other microbiota can.

Lactobacillus Rhamnosus helps prevent anxiety and depression by upregulating GABA. L Rhamnosus also prevents lactose intolerance, asthma and allergies. It also prevents skin rashes and eczema. L Rhamnosus also prevents urinary infection. Helps restore normal vaginal and bladder microbiome. Helps prevent candida and fungul infections. Helps prevent inflammatory bowel diseases. Reduces oxalates. Prevents food sensitivities. Breaks down histamines. Reduces endotoxins and inhibits biofilm formation. It simulates phagocytosis which helps fight infection. Phagocytosis is inhibited in those with immune deficiency. Reduces histamines. Rhamnosus improve bowel movements by increasing intestinal motility. Has been shown to prevent chronic fatigue.

Lactobacillus Acidophilus prevents excessive weightloss and reduces inflammation. Has been shown to reduce symptoms of arthritis. L Acidophilus increase CB2 receptor expression. Prevents urinary and bladder infection and helps keep the ph of the bladder and intestines balanced. Helps prevent candida and fungul infections. Helps prevent inflammatory bowel diseases. Prevents celiac disease, milk allergies and food sensitivities. L acidophilus helps with FODMAP intolerance and has been shown to reduce SIBO. It reduces pain by stimulating the opioid receptor. Helps prevent acne. Helps prevent allergies and food intolerances. Helps prevent infection in the bladder and intestines by balancing the ph. If we become too alkaline it promotes pathogen growth. It also prevent vaginal infections. Has been shown to protect the health of the pancreas. Increases IL-10.

Mycobacterium Vaccae helps prevent brain inflammation, anxiety and depression. It also improves cognitive function. It is found in healthy soil in forest among decaying folage. Supposedly eating leaves from a plant can give you this. It induces a strong T cell response when first establishing in the body and then slowly declines as it gets established. Once established it increases T regulatory cells. It helps fight tuberculosis.

Almost all bifidobacterium prevent depression and anxiety but can cause weight loss so those who are under weight my want to be cautious in taking these in excess. Red Wine increases Bifidobacterium. The bifidobacterium also decreases adrenalin levels.

Sophora has been found to increase most of the bacteria that prevent anxiety and depression.

Lactobacillus Iners promotes vaginal dysbiosis so should be avoided , high levels can cause miscarriage. It increases risk of contracting sexually transmitted diseases. One good thing about it is it prevents HPV infection.

Lactobacillus Jensii reduces the risk of contracting sexually transmitted diseases and renal infection. It helps with the break down of milk. It reduces the population of other Lactobacillus which can help with obesity. Lactobacillus Jensii produces chemicals that inhibit HIV. Helps restore normal bladder and digestive microbiome. Helps protect from HPV infection. It helps maintain the proper PH of the intestines and the bladder.

Lactobacillus Crispatus causes weight loss in those who are obese and protects from infections in the renal system, bladder and prevents sexually transmitted diseases. It helps keep the ph of the bladder and digestive system balanced. Helps restore normal gut and bladder microbiome. Helps protect from HPV, HIV and many other types of infection. It prevents vaginal odor.

Lactobacillus Johnsii requires purines to survive so needs purine producing commensals or purines consumed in the diet. It produces natural antibiotics that protect the gut from infection and prevent H Pylori and Candida from becoming pathogenic. It has been shown to thicken the mucous membrane in the gut and helps heal peptic ulcers. It restores the proper number of IgA, IgG and CD8+ cells which are low in tick born illness and inflammatory bowel and malabsorption disorders. It helps prevent skin lesions. It has been shown to reduce diabetes and even reverse it in some. L Johnsii prevents insulin resistance and allergies. It also prevents vaginosis. Those with interstitial cystitis or high TH17 levels would want to avoid this one because it increases TH17 levels along with COX2 which is high in interstitial cystitis, psoriasis, and lupus. It would help restore nutrient absorption in those with malabsorption.

Lactobacillus Kefiranofacians is found in kefir and fermented milk. It prevents cavities and biofilm formation. It does not survive in the gut long so you would have to gargle with it. It also helps with constipation. It stimulates the intestines to produce more mucin increasing the mucous membrane in the gut which helps with colitis. Those with high TH1 levels would want to avoid it because it increases TH1 levels.

Lactobacillus Kimchii increases phagocytosis which would not be good in those with a hyper immune system but would help those who have an inhibited immune system. It is found in kimchi. Kimchi also contains Lactobacillus Sakei which inhibits biofilm formation.

Lactobacillus Plantarum has potent antioxidant abilities. It helps maintain proper intestinal permeability and helps with malabsorption disorders. It produces antimicrobials that fight gram positive and gram negative bacteria. It accelerates gut repair. It helps with chron’s and inflammatory bowel disease. It reduces skin rashes and eczema. It has been shown to help with diabetes. It prevents diabetes and high blood pressure. L Plantarum also prevents biofilm formation. L Planatarum increases muscle mass, muscle strength and endurance. Helps prevent candida and fungul infection. Helps prevent inflammatory bowel diseases. Reduces oxalates. Breaks down histamines. L Plantarum improves intestinal epithial health. It produces L-Lysine which improves our bodies ability to use calcium. It has been shown to improve mental health. It is improves the absorption of nutrients into the body. It helps remove toxins from the body.

Lactobacillus Pontis increases NOD2 which fights viruses but is not good for those with inflammatory diseases or inflammatory bowel disease.

Bifidobacterium Adolenscentis helps break down milk proteins, promotes normal bowel movements, produce many of the same vitamins that most Bifidobacterium produce which includes B1, folate, B12, biotin and riboflavin. It also produces vitamin C but not in high enough amounts to provide the body with adequate levels of vitamin C. It like most Bifidobacterium dephosphoralizes phytic acid. Which prevents the antinutrient effect of Phytic Acid. If a person is low in Bifidobacterium then phytic acid will deplete their bodies of nutrients. It helps fight Coxsackievirus and other viruses. If a person is deficient in Bifidobacterium they are more prone to Norovirus infection. It along with most bifidobacterium prevents obesity, cardiovascular disease and diabetes.

Streptococcus Salvarius prevents infection in the throat nose and mouth. It also produces natural antibiotics that kill harmful bacteria. Prevents food allergies. It also prevents lung infection.

Streptococcus Mitis prevents infection in the throat nose and mouth.

E Coli Nissle prevent E Coli infection, prevents halitosis, helps prevent infection in the mouth , throat and nose. Helps with inflammatory bowel diseases. E Coli Nissle protects us from it’s pathogenic cousins. It also protects from other food born illness.

Lactobacillus Salvarius prevents cavities and prevents biofilm formation and prevents dental plaque. Helps prevent fungul infection and candida.

Lactobacillus Coagulans (Lactobacillus sporogenes ) helps prevent inflammatory bowel diseases. Has been shown to prevent diabetes. It enhances protein absorption and increase muscle healing, improves muscle recovery time and increases endurance. It inhibits fibrosis which would help with fatty liver disease and COPD. It increases butyrate producing bacteria. It decreases abdominal pain. It requires oligosaccharides. It improves bowel motility which prevents constipation. It reduces symptoms of inflammatory bowel diseases. It helps improve feeding tolerance. In other words it helps restore your appetite.It prevents parasite infections and has been shown to protect against the flu and adenovirus. It has been shown to reduce vaginosis. It also protects from many pathogens that cause diarrhea.

Lactobacillus Gasseri prevents halitosis. Helps restore normal bladder and gut microbiome. Reduces oxalates and histamines. Helps protect from HPV infection. It reduces menstrual pain. Reduces allergies and asthma. Helps break down phytic acid preventing it from being and antinutrient.

Bifidobacterium Animalis prevents food allergies and reduces oxalates. Prevents constipation speeds up food transit time. It prevents bloating, nuero inflammation, oxidative stress, and increases serrotonin, dopamine and norepineprhine by inhibiting MAO activity. Prevents obesity and anemia. It protects from polio and rotavirus. It reduces the length of the flu and prevents lung infection. I reduces allergies but increases TH1 levels. It reduces inflammation and increases T regulatory cells. It increases good gut microbes and decreases the bad. Improves digestive health. Prevents diarrhea and constipation. Helps with colitis and inflammatory bowel disease. It enhances immunity. It helps prevent celiac disease. It degrades oxalates. It improves nutrient absorption. It reduces stress hormones helping to reduce anxiety.

Bifidobacterium Adolescentis prevents food allergies and reduces oxalates. It prevents diarrhea from pathogens and prevents constipation. It helps protect from the rotavirus. Prevents asthma. Inulin increases B Adolescentis. It is fed by F Prausnitzii. It helps reduce fatty liver disease.

Akkermansia Muciniphila helps prevent obesity and helps to produce short chain fatty acids and is usually low in those will malabsorption issues. Deficiency in Akkermansia Muciniphila can lead to diabetes. Akkermansia Muciniphila also protect us from inflammation. It is important in homeostasis in the gut. It also produces oligosaccharides which feed our good gut microbes. It helps produce SCFA which are needed by the body and our microbiome. It helps maintain the shape and health of the mucous membrane in the gut. Low levels of Akkermansia Muciniphila results in a thinner mucous membrane making us more prone to infection and inflammatory bowel diseases. A deficiency in Akkermansia can result in appendicitis. Arabinoxylin, Inulin , fructoligosaccharide, oligofructose increases Akkermansia. Polyphenols in pomegranate, grapes, grape seed extract , and navy beans increase Akkermansia. Cod liver oil also increases Akkermansia. When there is a wound in the gut Akkermansia will go to the site of the wound and signal the body it needs to repair that area. This is one of the most important microbes for gut health. If we are deficient in it bacteroidetes leves get to high, bile production becomes inhibited and our bodies do not secrete pancreatic enzymes. I discuss the consequences of high bacteroidetes levels at the end of this post. Increased CB1 receptor activation reduces Akkermansia, inhibiting CB1 receptor increases Akkermansia but inhibiting CB1 increases depression and anxiety. Akkermansia needs Faecalibacterium Prausnitzii and vice versa. There is research showing if Akkermansia levels get too high it can increase zonulin levels so though it is a key mcirobiota in the regulation of our health homeostasis should always be the goal.

Clostridium Butyricum help prevent many food born pathogens, helps produce short chain fatty acids, it prevents diabetes and helps keep the sulfur digesting and ammonia producing bacteria like Bacteroidetes and Firmicutes from getting too high. If those are high a person can develop diabetes, malabsorption from inhibited bile production and inflammation. It prevents insulin resistance. Clostridium Bytyricum also protect from bartonella.

Faecalibacterium Prausnitzii Faecalibacterium a deficiency can lead to irritable bowel syndrome. Produces butyrate from fiber. A deficiency in F Prausnitzii can lead to asthma, obesity, depression ,Chohn’s disease and inflammatory bowel diseases. A deficiency in this can lead to high TH17 levels resulting in psoriasis. Those with cardiovascular disease and Type 2 diabetes are usually low in F Prausnitzii. Akkermanis Municiphila needs it and vice versa. Prevents inflammation.

It also helps balance the immune system. It needs Akkermansia to thrive. Oligosaccharides increase F. Prausnitzii. It prevents celiac disease. It induces IL-10. It is necessary for fatty acid oxidation. It produces butyrate. It produces Salicyclic acid which is what they make aspirin from. It produces raffinose a type of oligosaccharide that decreases gut permeability which prevents leaky gut. It along with other commensals form biofilms that help protect and heal the gut. Decreases zonulin which preserves the integrity of the tight protein layer. If zonulin levels get too high a person will develop lactose, gluten and gliadin intolerance.

Enterococcus faecium prevents listeria infection and prevents infection from it’s pathogenic cousins. There is a human species which is non pathogenic and an animal species and the animal species is pathogenic to humans. I view this one as a dangerous pathogen even though it is used in probiotics when the body is weak it can make a person very very ill.

Weissella Cibaria also prevents halitosis, cavities, and this one also reduces skin lesions. It also reduces Hydrogen Sulfide and inhibits biofilms. Weisella Cibaria is found in kimchi and fermented milk. It prevents inflammation caused by endotoxins. It also prevent Nirtic oxide induced by endotoxins and promotes the healing of intestinal epithelial cells. It inhibits biofilm formation of pathogenic microbes.

Preovotella Histicola reduces arthritis, increases T regulatory cells and IL-10 which help keep the immune system balanced and reduces TH17. These are often a problem in those with tick born illness or mycoplasma infection. Reduces allergies.

Collinsela Aerofaciens increases intestinal PH which prevents pathogens and keeps candida and H Pylori in their commensal forms. It has been shown to prevent irritable bowel syndrome. It requires maltose, lactose or glucose. Whole grains increase C Aerofaiens. It prevents arthritis by inhibiting IL17.

Lactobacillus Bulgaris increases life span. Helps maintain the proper PH of the bladder and intestines which prevents infection and dysbiosis. Prevents the bladder and intestines from becoming alkaline. If they become alkaline candida and H pylori will go from commensal to pathogenic. It balances the microbiome in the digestive system. It also helps prevent lactose intolerance. It helps prevent liver disease and has been shown to reduce the risk of getting the common cold. It prevents dermatitis and eczema. It has been shown to help with inflammatory bowel disease. It prevents tooth decay and also prevents infection in the intestines and prevents pouchitis. It prevents constipation. It helps neutralize many toxins.

Odoribacter Splanchnicus a loss of Odoribacter causes a loss of SCFA availibility which leads to inflammation and low glucose levels. Deficiency in O Splanchnicus can lead to hypertension and diabetes. Low levels of O Splanchnicus can also lead to interstitial cystitis. It is important for absorption of nutrients and in maintaining a healthy gut. Has been shown to prevent atherosclerosis. Requires glucose, galactose, salicin, trehalose, arabinose, fructose or mannose. Inhibits many of the sulfur digesting bacteria that can cause high sulfite levels and high hydrogen sulfide levels. O Splanchnicus also breaks down phytoestrogens found in many plants.

Lactinifactor Longoviformis breaks down phytoestrogens found in many plants.

Arthrobacter Agilis it produces carotenoids which the body can convert to vitamin A. It reduces the risk of Parkinson’s disease. They degrade many pesticides. It prevents fungus infection but I am not comfortable with Arthobacter species because some of them produce antifreeze and I cannot find any research to show with this one did or not. I do not feel this is a safe probiotic and I have not spoken to anyone who had used it.

Eubacterium Halli it produces butyurate from acetate, glucose and lactate. It produces vitamin B12. It is important for homeostasis in the body and produces SCFA. It improves insulin sensitivity and normalizes blood glucose levels. It cannot process complex carbohydrate and needs bifidobacterium to exist. It makes some carcinogens harmless.

Arthrobacter Globiformis uses sugar as it’s main source of food. It uses sugar and ammonia. It’s byproducts are nitrogen and hydralimine. I do not know the health effects of these but it can break down many toxins in the enviroment but I do not feel comfortable using these as a probiotic I have not seen enough research on the use of this. Their are many of the Arthrobacter species that are used for probiotics and almost all of them break down some form of toxin but I cannot find research on their safety or effectiveness.

Pediococcus acidilactici it has been shown to reduce gastrointestinal distress. It prevents infections by food born pathogens and has been shown to stop bloody diarrhea. It also prevents constipation. Has been show to stop excessive vomiting. It has been shown to fight pathogenic parasites. It increases IL-10 and T regulatory cells which would balance the immune system. It has also been shown to fight fungal infections.

Most Bacillus species convert genotoxic substances to non toxic substances. Bacillus species are found in the soil and in humans. Some can be pathogenic. Man soil based bacteria improve nutrient absorption. There are other strains of Bacillus species but I did not list them because they have the ability to produce endotoxins. Bacillus species help break down food better which improves nutrient absorption. They should be taken with food or they do not get established well. Many of the Bacillus species secrete amylase and lipase. Amylase helps break down carbohydrates and lipase breaks down fats. Bacillus species may help those with malabsorption issues. Bacillus species detox a lot of toxins including mycotoxins found in fungus and molds. Mycotoxins can cause birth defects, sterility, it can increase estrogen levels. Most bacillus species can detox mycotoxins zearalenone, and aflatoxin but other mycotoxins that get broke down are species specific. Most Bacillus species train the immune system on how to fight pathogens. Most bacillus species reduce the risk of diabetes and cardiovascular disease. Most bacillus species help prevent leaky gut and promote healing of the gut.

Bacillus Lacterosporous is found in soil and humans. It fights fungus. Helps prevent leaky gut. It also fights mycoplasma infection. I have not seen studies on the effectiveness or safety of this microbe.

Bacillus Firmis promotes the differentiation of B lymphocytes to Ig producing and secreting cells. It stimulates the repair of blood vessels.

Bacillus Clausii stimulates the production of IgA but requires GALT. Prevents lung infections has been used successfully to treat those who get recurrent respiratory infections. Has also been used successfully to treat acute diarrhea. Studies show it is safe for human consumption. It protects the body from endotoxins.

Bacillus Licheniformis prevents biofilm formation of pathogens. Prevents the build up of amyloid plaque which contributes to amyloidosis and Alzheimer’s. Amyloid can also destroy beta cells leading to diabetes.

Bacteroides Fragilis promotes the production of GALT.

Phages P. Aerugonosa protect against E Faicalis and many food born pathogens.

Bacteroidetes- there are many species. Meat consumption increases their numbers. If bacteroidetes get too high it can result in weight gain or weight loss from malabsorption. It can cause the inability to absorb fats preventing bile production. It can cause the pancreatic enzymes to become inhibitited and cause phenylketonuria which results in high ammonia levels. It can cause BH4 enzyme deficiency, which can lead to CBS upregulation which can lead to high sulfite levels. This can cause the citric acid cycle to shut down leading to high estrogen levels, high unbound copper levels which farther inhibit the bodies ability to produce bile. This farther increases estrogen levels and levels of unbound copper. This lead to inflammatory bowel disease and malabsorption issues. A person with high Bacteroidetes levels will be high in butyrate and proprianic acid, acetate levels may be high also. They will be low in malanic acid. This also leads to high ammonia levels which causes many other health issues and causes Candida and H pylori to go from commensal to pathogenic. Many with this problem will develop bile acid gird. This also makes someone prone to clostridium infection along with many other pathogens.

If this persist long enough a person can develop interstitial cystitis. This is a common problem in those born by C section and who are formula feed. This also leads to a lot of food intolerances especially milk and glutin along with gliaden. This also can result in thiamine deficiency.

Consuming high amounts of meat can result in high bacteroidetes, methane producing bacteria and increased sulfur digesting bacteria. This can result in high levels of sulfite which will interfere with sulfation and cause many health issues. It can also cause high levels of hydrogen sulfide which will lower blood pressure at first then if levels get high enough it will increase blood pressure and cause severe inflammation. Bile production and production of pancreatic enzyme will become inhibited. High sulfite levels makes a person more susceptable to Salmonella infection. This also inhibits bile production. Butyrate ;producing bacteria help restore bile production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023267/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953422/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282957/

Another thing that inhibits bile production is extended use of antibiotics. It reduces our good gut microbiome. Muscrarlis Macrophages detect our good gut microbiomes LPS. With the decrease in our good gut microbiome and loss of their LPS to signal muscarlis macrophages dysbiosis occurs which leads to inhibited intestinal motility which causes a loss of bile production and pancreatic enzyme production. Supplementing with commensal LPS has been shown to reduce the symptoms and increase bile flow.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149228/

https://www.cell.com/abstract/S0092-8674(14)00735-1

https://www.cell.com/cell/pdf/S0092-8674(14)00867-8.pdf

A loss of bile production prevents nutrient absorption, the pancreas will not receive the feedback from our intestines and will quit producing enzymes. This result in malabsorption especially of oil soluble nutrients because bile is need to break down fats. This will also cause LDL levels to get low and HDL levels to because high. This imbalance causes HDL to become inflammatory.

A loss of serrotonin producing gut bacteria negatively impact gut health. Tryptophan helps restore gut health. Strange thing is the first three or four days I took tryptophan I had a herx type reaction. It must have been from die off of the bad gut microbes as the good increased. This can lead to damage to the central nervous system.

http://www.pnas.org/content/115/25/6458

https://www.gastrojournal.org/article/S0016-5085(16)34896-X/abstract

Grape seed extract helps restore bile flow.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817264/

If normal bile function is not restored it effects the whole body and can lead to diabetes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073382/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319718/

https://www.frontiersin.org/articles/10.3389/fmed.2017.00163/full

Good articles on reducing candida when it turns pathogenic.

http://www.gestaltreality.com/2013/09/16/how-to-eliminate-candida-biofilms/

https://www.yeastinfectionadvisor.com/candidadiet.html

https://www.theguthealthprotocol.com/wp/the-alkalizing-myth

https://www.selfhacked.com/blog/treat-cure-candida/

https://www.thecandidadiet.com/candida-fighting-foods/

Sometimes people confuse candida with gut dysbiosis.

http://www.ei-resource.org/illness-information/environmental-illnesses/candida-and-gut-dysbiosis/

http://www.holistichelp.net/blog/candida-sibo-or-h-pylori/

If our ammonia levels get high then H Pylori will turn pathogenic to protect itself. When in commensal form it prevents allergies. When H pylori is in pathogenic form it inhibit ghrelin which inhibits digestion and can cause food to sit in the gut and ferment leading to bloating, dybiosis and can inhibit digestive enzymes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888205/

I am not going to cover histamines in this post I will address it in a post on over and under methylators because high and low histamines can cause over or under methylation. Leaky gut, inflammation and status of our immune system can effect methylation.

Now connect this with my other post and you will see that there is no doubt that germ theory and terrain theory are not correct and that our Facebook groups theory “Enveroment and Biome Theory of Health is correct.

Here is a list of my articles on health that will support my case.

Improtance of human photosynthesis in health.

https://iamajuicer.wordpress.com/2018/11/13/importance-of-human-photosynthesis-in-health/

Why so many are experiencing gender identity crisis.

https://iamajuicer.wordpress.com/2018/11/12/why-so-many-are-experiencing-changes-in-gender-identity-why-so-many-children-have-gender-identity-issues/

We can expect diabetes to rise because of all these things.

https://iamajuicer.wordpress.com/2018/07/21/diabetes-type-1-type-2-and-type-3c/

You can use the above mentioned information to help with hypertension.

https://iamajuicer.wordpress.com/2018/10/28/causes-of-hypertension-and-things-that-may-help/

https://iamajuicer.wordpress.com/2018/10/24/the-truth-about-heart-disease-cholesterol-lowering-drugsand-their-effects-on-mental-health-and-health-of-the-body/

https://iamajuicer.wordpress.com/2018/07/25/carditis-hypertension-tachycardia-and-many-other-cardiovascular-disease-all-have-a-common-tie-and-common-solution/

Compare the above mentioned things and the things that occur within the body and you can make the connection to the gut. This list the many things that can go wrong and how to use nutrients to help heal.

https://iamajuicer.wordpress.com/2018/10/12/my-summarized-notes/

Even allopathic medicine is contributing to the chronic illness and the poor health of modern day society so they are the bad environmental part.

https://iamajuicer.wordpress.com/2018/10/08/cause-of-flaccid-myelitis/

Even our brain gets effected.

https://iamajuicer.wordpress.com/2018/10/02/cant-sleep-feel-disassociated-could-be-your-pineal-gland/

https://iamajuicer.wordpress.com/2018/09/21/things-linked-to-alzheimers-and-chronic-illness/

https://iamajuicer.wordpress.com/2018/07/11/hyper-excitement-of-nmda-autism-also-known-as-encephalitis/

We are taught that things like genetics are inherited but it is our eating habits and microbiome that gets inherited and they are things that can be changed. Even asthma we are taught is inherited but I have seen many in my life correct it and live a normal life and never suffer from it again.

https://iamajuicer.wordpress.com/2018/09/22/causes-of-obesity-and-things-that-may-help/

https://iamajuicer.wordpress.com/2018/09/20/why-asthma-is-rampant-now/

We are told that our genes are written and cannot be changed but science is finding that is not true.

https://iamajuicer.wordpress.com/2018/09/02/1303/

Stomach problems they claim runs in families but it is actually the gut microbiome they inherited and can be corrected.

https://iamajuicer.wordpress.com/2018/09/02/the-microbes-that-help-heal-the-gut/

https://iamajuicer.wordpress.com/2018/08/21/things-that-may-help-those-who-have-the-more-difficult-digestive-problems/

Many have problems with lipid metabolism now days. They claim it is inherited genetics but when I ask people if anyone else in there family suffered from it they say no. So how can it can they inherit something no one else ever experienced in their families?

https://iamajuicer.wordpress.com/2018/08/21/things-that-may-help-with-lysosomals-storage-disease/

The above mentioned things should help with liver disease also.

https://iamajuicer.wordpress.com/2018/08/14/fatty-liver-cirrohsis-thrombosis-and-other-diseases-caused-by-fibrosis/

Many things like COPD are set off by infection or toxins. By now you should know that most supposed pathogens actually help the body unless we have too many toxins or we are lacking a nutrient.

https://iamajuicer.wordpress.com/2018/07/20/things-that-may-help-with-copd/

This is why cancer is so rampant. Cancer is pretty much caused by man and the environment men have created.

https://iamajuicer.wordpress.com/2018/07/29/cancer-what-causes-it-what-may-help-with-it/

https://iamajuicer.wordpress.com/2018/07/22/what-they-dont-want-you-to-know-about-cancer-and-why-so-many-children-are-getting-it/

Our enviroment and biome can effect our health by causing excess oxidative stress.

https://iamajuicer.wordpress.com/2018/08/02/oxidative-stress-the-antioxidant-systems-and-how-they-effect-our-health/

Now you can see why tick born illness is rampant. Thing that usually would not usually effect man is now causing illness. Infection indicates there is a nutrient deficiency or enviromental toxin or enviromental biome issue. Something is out of balance. Man is viewing symptoms like cancer, diabetes, and mental illness as the cause and they are symptoms of underlying problem.

https://iamajuicer.wordpress.com/2018/06/17/vaccinations-spread-and-cause-disease/

https://iamajuicer.wordpress.com/2018/10/08/cause-of-flaccid-myelitis/

https://iamajuicer.wordpress.com/2018/07/21/things-they-would-rather-you-did-not-know-about-lyme/

Vaccination are one of the biggest contributors of modern illness.

https://iamajuicer.wordpress.com/2018/07/13/identifying-vaccine-injury-and-its-cost-to-society/

This is why detoxing is so important now days. Even our food has become toxic. Organic helps reduce the impact of mans destruction of our environment and the human and planetary biome.

https://iamajuicer.wordpress.com/2018/07/14/detoxing-we-need-it-now-days/

https://iamajuicer.wordpress.com/2018/07/23/how-toxic-is-your-food/

https://iamajuicer.wordpress.com/2018/06/17/genetically-modified-foods-destroy-our-health-glyphaste-and-glufonisate-add-to-the-toxicity/

They know their science is fake so they use every tactic they can to hide that fact.

https://iamajuicer.wordpress.com/2018/08/11/tactics-used-by-corporate-science-to-deceive-people-into-no-asking-questions/

If you have read this then by now it have figured out it is not your genes but your enviroment, inner and outer biome and not your genes that effect your health.

https://iamajuicer.wordpress.com/2018/06/27/its-not-your-genes-it-is-your-gut-microbiome/

Histamine homeostasis is very important in fighting chronic illness.

https://iamajuicer.wordpress.com/2018/07/12/the-effect-of-high-or-low-histamines/

Since modern day illness is causing chronic illness by destroying our gut we need to work on restoring it to heal. Leaky gut causes endotoxemia. I listed in the microbe list above which ones reduce endotoxins. It also causes high oxalates so you will have to work on reducing them.

https://iamajuicer.wordpress.com/2018/06/28/leaky-gut-oxalates-and-more-supplement-information/

https://iamajuicer.wordpress.com/2018/07/08/dealing-with-endotoxemia-or-sepsis/

All these things are types of autoimmunity and we need to restore our immune system back to homeostasis.

https://iamajuicer.wordpress.com/2018/07/15/autoimmunity-what-causes-it-and-things-that-may-correct-it/

Interstitial cystitis and vaginitis are some of the worst autoimmune disorders to deal with because our modern day environment makes it difficult to acheive homeostasis in the areas effected.

https://iamajuicer.wordpress.com/2018/07/15/causes-of-vaginitis-thinning-or-atrophy-of-the-vaginal-walls-and-things-that-may-help/

https://iamajuicer.wordpress.com/2018/06/18/healing-interstitial-cystitis/

 

Constipation can lead to inflammatory bowel disease and inhibited bile productin and  is caused by an imbalance in our gut microbiome. It can lead to chronic illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951383/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872693/

I noticed that those with dysbiosis had issues when the consumed or took tryptophan. This study suggest that SERT might be upregulated in dysbiosis which wold explain why tryptophan made them worse. Sert is the serotonin transporter.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583244/

https://www.nature.com/articles/s41598-017-10835-8

There are those who say but things like H Pylori cause illness. So how could that prove what your are saying. H Pylori just like many of our beneficial bacteria only cause problems when something has changed to cause it to occur. They say yeah but there is strains that are pathogenic and strains that are not. Well the biggest part of the population is believe to have the supposed pathogenic strain of H Pylori. So you have to ask why doesn’t everyone get gastric ulcers?

https://www.frontiersin.org/…/10…/fmicb.2018.00609/full

Even our good gut bacteria can cause illness if we have digestive problems.

https://www.sciencedirect.com/science/article/pii/S1198743X14618838

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490230/

Our food and water is so toxic now it has a negative impact on our guts. The crazy thing is some of these toxins are found in vaccines so imagine what they are doing when they are being directly shot into peoples blood streams.

https://www.mdpi.com/2076-2607/6/2/53/htm

Desulfibrio species digest sulfur which produces H2S. If H2S levels get too high it can cause many health issues. B Thetamiomicron free sulfur which feeds Desulfibrio species. They cannot free it themselves. Mercury and lead increase Desulfibrio species. Excess H2S can lead to constipation. This is why high levels of Akkermansia and Desulfibrio results in inflammatory bowel diseases, gall stones and many other diesease. Not getting enough fermentable carbohydrates increases sulfur digesting microbes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1233901/

https://www.ncbi.nlm.nih.gov/pubmed/26491870

https://www.ncbi.nlm.nih.gov/pubmed/19709217

https://www.tandfonline.com/doi/abs/10.3109/00016357.2013.770163

https://www.frontiersin.org/articles/10.3389/fmed.2017.00163/full

It is listed among the bacteria that increases the risk of heart disease and diabetes.

https://www.ncbi.nlm.nih.gov/pubmed/29800124

Glycomacropeptide found in whey protein and fermentable fiber reduces sulfur digesting bacteria. Fermentable fibers are pectin, Beta-glucan found in mushrooms and oatmeal, guar gum, inulin and oligosaccharides. If a person is not used to getting them they will have to ease into them. Until the body is used to getting them they will cause bloating and gas. As the body gets used to them the symptoms will slowly decrease. Psyllium should be avoided it has been found to make the symptoms worse.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593820/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190755/

Those with inflammatory bowel and gut dysbiosis usually have high levels of H2S being produced by their gut microbes. Fructooligosaccharide and Resistant starch decreases H2S but psyllium increases it so psyllium should be avoided.

https://www.ncbi.nlm.nih.gov/pubmed/29561196?fbclid=IwAR3wOZijtOeO0NF_4liAPIZwHwiK-bAqMn4IsPFQNQ1PbkuJU0cydwzuFs0

Strange lactulose is in raw milk increases Hydrogen production but it helped me.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201941/

Now we do not want to completely rid ourselves of the H2S producing microbes because they are needed to keep us health. We want to try and restore homeostasis. For those with high sulfur digesting bacteria a glass of non sulfur wine may help.

https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.855.3

High H2S levels can effect sulfation by inhibiting sulfur detoxification. It can even effect the antioxidant system. High H2S levels also inhibits nNOS. It can be countered by increasing NADPH and BH4.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040266/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210431/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599001/

Methane producing bacteria can also cause constipation leading to inflammatory bowel diseases. Those with high methane levels usually suffer from nausea, will feel full and bloated, may experiencing vomiting. They will have milk intolerance because the sugars in milk feed methane producing bacteria. They will experience bouts of severe depression. Constipation causes bile to become inhibited resulting in similar health problems as those who have high sulfur digesting bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987281/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544731/

For those with dysbiosis from high methane producing bacteria should not drink alcohol it can make it worse.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544731/

Those with methane producing dysbiosis need to avoid fermentable carbohydrates and lactulose found in milk products. I know those feed the good gut bacteria but they also feed the gut bacteria that produce hydrogen which feeds the methane producing bacteria.

https://bellalindemann.com/treat-constipation-causing-methane-sibo/

Methane producing bacteria out compete Sulfur digesting bacteria for H2 unless sulfate is present.

https://gut.bmj.com/content/32/12/1498

This surprised me the same microbes that feed the sulfur digesting bacteria also feed the methane producing bacteria. Firmicutes and bacteroides is high in both types of dysbiois.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC442992/

This is another commonality that I have found with those who have inflammatory bowel from too many sulfur digesting and too many methane producing is they both had low bacteroides fragilis levels. I am cautious recommending this because if level get too high it can cause health problems.

https://www.hindawi.com/journals/bmri/2016/5828959/

Bacteroides vulgatis and Bacteroides Dorei are usually low in both types of inflammatory bowel and can lead to cardiovascular disease. Seems there is an easy fix for this. Eating walnuts. This should help Both types of inflammatory bowel issues.

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.033714

https://www.fasebj.org/doi/abs/10.1096/fasebj.29.1_supplement.1006.1

Excessive methane production or excessive hydrogen production can cause malabsorption. So both should be measured in those with malabsorption issues.

http://iopscience.iop.org/article/10.1088/1752-7155/7/2/024001/meta

Alcohol consumption should be avoided with methane producers because it increases methane.

https://www.nature.com/articles/s41598-017-07637-3

The gut microbes are dramatically different in those with NAFLD.

When you look at studies on cirrhosis of the liver. The things that help NAFLD seem to be things that improve oxidation which leads me to believe they are low oxidizers. But alcohol liver disease seems more inflammatory. But they both have links to the gut. Very interesting report.

https://www.mdpi.com/2072-6643/10/10/1457

If a person craves sugar it may mean their lactobacillus acidophilus levels are too high.

Microbes interact with our mitochondria including our gut microbes.

https://academic.oup.com/femspd/article-pdf/74/1/ftv096/10749982/ftv096.pdf

Chemicals in our environment and those pushed by the pharmaceutical industry change our external environment which is killing the commencile pathogens that keep the pathogenic ones in check. This is a common theme now days. When someone gets and infection they either have high toxin levels, were taking allopathic medications or had a nutrient deficiency. All those effect our commensals that protect us from their pathogenic cousins.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510460/

Some functional food that help straighten the gut out.

https://www.frontiersin.org/articles/10.3389/fmicb.2017.02146/full

https://www.frontiersin.org/articles/10.3389/fvets.2018.00166/full

 

Probiotics and their effects on autoimmune disease.

https://www.mdpi.com/2072-6643/10/10/1537/htm

And yes autoimmunity can lead to mental illness that is why vaccine damage the brain.

https://onlinelibrary.wiley.com/doi/full/10.1111/imm.12943

Using the information on probiotics above you can see the connection between the gut and arthritis.

https://www.mdpi.com/1422-0067/19/9/2508

Those with Trimethylaminuria may be deficient in sulfur digesting bacteria. This would reduce TMAO in the plasma. Could Trimethylaminuria be from a deficiency in methane producing and enterobacteriaceae?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239492/

https://www.nature.com/articles/ismej201772

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0461-0

How microbes effect neurological stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736941/

This report shows why it is important to address leaky gut and gut dysbiosis. It can damage the kidneys.

https://www.mdpi.com/2072-6651/10/7/300

Methylation issues must be addressed before you can get your gut to heal.

Overmethylators

http://www.mensahmedical.com/common-symptoms-of-overmethylation/

Undermethylators.

http://www.mensahmedical.com/common-symptoms-of-undermethylation/

IL-22 is needed to protect us from pathogens and to stimulate FUT2. If we are deficient in certain gut microbiota that stimulate FUT2. We will have immune issues and gut dysbiosis because FUT2 keeps our good gut microbes health.

http://www.traceyreed.ca/blog/2016/4/12/fut2s-role-in-gut-healths-role-in-gut-health

https://www.sciencedirect.com/science/article/pii/S0022283615006051

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774895/

ILC3 is needed for our gut microbiome to communicate with the body to increase FUT2. ILC3 is secreted by our gut microbiome.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774895/

http://science.sciencemag.org/content/345/6202/1254009.long

https://www.researchgate.net/publication/260808789_Microbiota-Dependent_Crosstalk_Between_Macrophages_and_ILC3_Promotes_Intestinal_Homeostasis/download

Oligosaccharide helps if someone is deficient in FUT2

https://nutritionfacts.org/2013/01/10/boosting-gut-flora-without-probiotics/

https://www.newhope.com/ingredients/oligosaccharides-revealing-more-health-benefits

If the immune system is out of balance IL-22 can be upregulated causing illness. This is why the microbiome that increase T regulatory cell and decrease inflammation are important and reducing endotoxins is also important.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710696/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117408/

https://www.dovepress.com/profile-of-interleukin-22-in-gut-mucosal-health-and-disease-peer-reviewed-fulltext-article-IJICMR

https://www.sciencedirect.com/science/article/pii/S0925443914001513

IBS with constipations is IBS-C, IBS with diarrhea is IBS-D, IBS that is mixed is IBS-M. Most I have met have IBS-C and it is why I post on constipation a lot.

5-HT(serotonin) helps regulate gut motility.

https://www.ncbi.nlm.nih.gov/pubmed/25954931

Lactobacillus Rhamnosus GG increases 5-HT uptake .This would help those who have diarrhea but will decrease motility adding to the problem for those who have constipation type inflammatory bowel. 5-HT plasma levels in those who have diarrhea is low and in those who have consipation it is high. E Coli Nissle 1917 increases 5-HT bioavailibility. F Prausnitzi A2-165 down regualates 5-HT which may help those with constipation type inflammatory bowel. Some of the studies were done poorly but there is useful information in them. They also list some microbiota that can improve motility.

https://www.wjgnet.com/1007-9327/full/v24/i3/338.htm

https://www.wjgnet.com/1007-9327/full/v22/i36/8137.htm

https://www.ncbi.nlm.nih.gov/pubmed/28871143

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583244/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951383/

There are three forms of IBS. IBS-D involves diarrhea, IBD-C involves constipation and IBD-M is a mix of both. Serotonin regulates gut motility and enzyme secretion. Damage to the digestive system and leaky Gut effects GLP-1’s ability to sense nutrients. 5-HT is involved in the regulation of gut motility and enzymes. It depends on GLP-1 and serotonin. Gut our gut bacteria regulate serotonin and GLP-1. The type of microbes involved in the dysbiosis determines which type of IBS a person will suffer from.

https://www.sciencedirect.com/science/article/pii/S2212877818301406

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263172/

Healing the brain and addressing high zonulin levels and restoring the gut bacteria and addressing neurological issues are necessary to restore proper gut brain communication. Inflammation must also be addressed.

https://www.frontiersin.org/articles/10.3389/fnins.2018.00049/full

http://www.mdpi.com/1424-8247/11/3/63/pdf

How metabolic issues disrupt the communication with our gut.

http://jem.rupress.org/content/213/10/2129

Our genes communicate with our gut bacteria.

http://jem.rupress.org/content/215/8/1965.long

http://cancerres.aacrjournals.org/content/77/8/1783

Our genes can be altered by our environment and what we put in them.

https://iamajuicer.wordpress.com/2018/09/02/1303/

A good article on the immune system and our gut.

https://www.karger.com/Article/FullText/484687

 

 

Things that may help those who have the more difficult digestive problems.

Mundinus,_Anatomia_Mundini..._Wellcome_L0027530

This is not medical advice I am posting this for informational and educational purposes.

If you truly want to heal it takes time and persistence. You have to develop your own protocol there is no one size fits all your protocol must be unique to you and your health problems. There is no magic bullet, pharmaceuticals treat the symptoms not the cause. So you may feel better but will slowly get worse until you will start needing other medications to hide the new symptoms that arise from the declining health which pharmaceuticals contribute to.

It takes a lot of research and patients. Take notes of what works and what does not and keep readjusting your protocol. As you heal your protocols will need to change.  Homeostasis is the goal once you start feeling better try cutting supplements out. If it goes well then take a maintenance dose of the supplement once in a while.

Mucilage every few hours helps a lot with leaky gut. When you have leaky gut it causes high oxalate levels. This causes a cycle that is hard to break because oxalates prevent the gut from healing. Mucilage can help heal the gut breaking the cycle. Mucilage helped me the most with healing my gut.

Things that are high in mucilage are Okra, organic Oatmeal, Aloe Vera I found the liquid gel worked the best dried aloe vera seemed ineffective. Besella Alba known as Malabar Spinach, Irish moss but you have to watch consuming it, it has a cannabinoid that reduces pain but has side effects if you consume too much. Most plants in the mallow family are very high in mucilage and have very good healing properties. Most plants in the dioscera family are high in mucilage especially the chinese wild yam. Fenugreek is high in mucilage. Flax seeds are high mucilage but if you have leaky gut they should be ground up to prevent other heath issues. Most seaweeds are high in mucilage. Licorice root is high mucilage but you have to make sure it is deglycyrrhizinated if not it can cause many health problems. Mullein is high mucilage and helps with lung infections. Most edible plants in the daisy and sunflower family are high in mucilage. Wild Daisy helped me a lot. Pysillium seed husk are high in mucilage they are seeds from the plantain herb. Plantain herb itself is very high in mucilage. Wild violet is very high in mucilage. Chia seed is high in mucilage most seed is. Slippery Elm is high in mucilage but some claim it is high oxalate , I have never tried it. Most roots herbs are high in mucilage. Arrow root is very high in mucilage.

https://mavcure.com/mucilaginous-herbs/

https://www.invitehealth.com/article-demulcents-and-mucilages-true-healers.html

Various gut microbiome and what they do.

https://www.vitamodularis.org/articles/how_to_interpret_your_microbiome_data.shtml

https://biofoundations.org/increasing-and-maintaining-akkermansia-muciniphila-for-a-healthy-gut-microbiome/

Oregano oil kills just about all pathongens in the gut.

https://www.bmj.com/content/352/bmj.i939/rr-1

Sage also is effective against bad gut bacteria.

http://www.scielo.br/scielo.php?pid=S0034-89102004000200025&script=sci_arttext&tlng=en

Verbana fights Citrobacter. I don’t know much about it but it has sedative effects and helps with seizures.

https://www.cogentoa.com/article/10.1080/23312009.2017.1363342.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5174135/

Beta Glucuronidase is low it can effect hormones. If it is high it can cause toxins reabsorption.

https://biofoundations.org/maintaining-a-proper-balance-of-beta-glucuronidase-for-disease-and-cancer-prevention/

High beta glucuronidase causes high estrogen.

https://www.planetnaturopath.com/hormones/high-beta-glucuronidase-and-how-it-affects-estrogen-and-detoxification/

Herbs that strengthen the immune system.

http://www.chiro.org/nutrition/FULL/Bacteria_That_Strengthen.shtml

We also need to reduce oxidative stress and nitrositive stress.

https://iamajuicer.wordpress.com/2018/08/02/oxidative-stress-the-antioxidant-systems-and-how-they-effect-our-health/

https://iamajuicer.wordpress.com/2018/07/11/nitrosative-stress/

Streptoccocus bacteria produce an exotoxins streptolysin and NAG -glycohydrolase which help it evade the immune system.

Inhibiting NLRP3 helps resolve the issues Streptolysin causes. It uses a tactic similar to Lyme disease it stimulates inflammation to evade the immune system.

https://www.frontiersin.org/articles/10.3389/fcimb.2018.00211/full

Rabdosia contains oridonin which inhibits NLRP3.

https://www.nature.com/articles/s41467-018-04947-6

There are a number of ways being used to inhibit NLRP3 inflammasome.

https://www.frontiersin.org/articles/10.3389/fphar.2015.00262/full

Resveratrol, quercetin and curcumin are NLRP3 inhibitors.

https://www.hindawi.com/journals/mi/2016/5460302/

Paeonia is a CBR2 activator which inhibits NLRP3.

https://www.ncbi.nlm.nih.gov/pubmed/25854559

CB2R receptor activation protects and heals the nerves.

https://www.nature.com/articles/cddis2014364

Hypoxia reduces NLRP3 and induces autophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524634/

https://www.tandfonline.com/doi/full/10.4161/auto.22783

bacillus subtillus kills most bad gut bacteria.

https://aac.asm.org/content/59/11/6844.full

https://www.tandfonline.com/doi/full/10.4161/viru.29514

https://www.sciencedirect.com/science/article/pii/S0168160511007136?via%3Dihub

We need butyrate producing bacteria to protect from inflammation. Also it protect the brain.

https://gut.bmj.com/content/63/8/1275.long

Fodmap diet helps with IBS.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555627/

Increasing Treg through FOXP3 cells helps.

https://www.hindawi.com/journals/jdr/2013/621693/

https://www.ndcn.ox.ac.uk/publications/692350

Our gut bacteria regualate T Reg cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276397/

https://ctajournal.biomedcentral.com/articles/10.1186/s13601-016-0108-9

Mycobacteria can inhibit NOD2 which can cause gut issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316803/

Infection can lead to NOD2 deficiency this causes a reduction in V-ATPase which is needed to produce stomach acid.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316803/

https://www.ncbi.nlm.nih.gov/pubmed/25335775

https://www.frontiersin.org/articles/10.3389/fimmu.2016.00367/full

Over stimulation of NOD2 can also make us prone to infections and chronic illness. Homeostasis should be the goal.

https://www.nature.com/articles/srep08383

https://www.spandidos-publications.com/10.3892/etm.2017.4288

https://www.kidney-international.org/article/S0085-2538(15)55943-7/pdf

HSP70 Restores NOD2 function. I have posted on HSP70

https://pubs.acs.org/doi/abs/10.1021/acs.biochem.7b00470?src=recsys&journalCode=bichaw

http://www.jbc.org/content/289/27/18987.long

Our diet and many probiotic strains can induce HSP70 which will restore NOD2 function which would restore dendric cell funtion.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892289/

Trypterygium Wilfordii may help restore NOD2 function though this is a single case report.

https://journals.lww.com/md-journal/fulltext/2017/11270/Case_report___remarkable_remission_of_SAPHO.114.aspx

Our diet and our gut interactions.

https://www.frontiersin.org/articles/10.3389/fimmu.2016.00290/full

Sulfation is involved in hormone production and use. Gut dysbiosis, glyphosate, mercury and other toxins can inhibit sulfation. This can result in hormone dysregulations. This can also result in high DHEA levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016456/

https://www.ncbi.nlm.nih.gov/pubmed/28153960

https://www.ncbi.nlm.nih.gov/pubmed/30087535

To much hydrogen sulfide producing bacteria lead to chronic illness.

https://www.physiology.org/doi/pdf/10.1152/physrev.00017.2011

https://pdfs.semanticscholar.org/1fda/f6c18c0b184ae8e41c8a777b2979bedd2494.pdf

Too many methane producing bacteria can lead to constipation there are some probiotics that will help with that.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609747/

http://www.talkingaboutthescience.com/studies/Donohue-Sulfoxidation.pdf

The craziest part of all of this is I seen supposed pathogens that could correct many of these issues but did not include them in this but they turn certain genes of which could restore the function of non-functioning genes.

Diets effect on gut bacteria.

https://www.aivpa.it/files/upload/rivista_articolo/00152_microbioma-dieta-disturbi-gastroenterici-e-disbiosi.pdf

https://watermark.silverchair.com/fux022.pdf?

http://www.drwallyschmitt.com/Newsletters/issue-43-molybdenum/

http://www.drmyhill.co.uk/wiki/Fermentation_in_the_gut_and_CFS

Tributyrin found in butter helps with dysbiosis

https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.994.9

https://biofoundations.org/multiple-health-benefits-tributyrin-triglyceride-form-butyrate/

Sulfur regulation in the body is very improtant.

https://www.mthfrsupport.com.au/wp-content/uploads/2017/04/PPT-CBS-Pathway-Final-full-page-slides.pdf

Dysbiosis often leads to impaired renal function.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431124/

Those who have gut issues will be deficient in short chain fatty acids and they are very important in maintaining our health.

https://biofoundations.org/multiple-health-benefits-tributyrin-triglyceride-form-butyrate/

Many will have high oxalate levels which are produced endogenously. I have posted on oxalates. This can prevent the gut from healing.

https://mthfrsupport.com/2018/03/understanding-sulfation-and-oxalate/

http://www.lowoxalate.info/research.html

https://people.csail.mit.edu/seneff/DC2016/CynthiaSmith_DC2016.pptx

Autophagy corrects lipid metablolism which is needed to produce bile and digestive enzymes. Bile homeostasis is very important for the health of the whole body.

http://jem.rupress.org/content/early/2018/01/12/jem.20171965.long

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930069/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247383/

Hydrogen peroxide is needed for lipogenesis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369955/

https://www.sciencedirect.com/science/article/pii/S0014579300021979

SOD increases H2O2. The only bioavialable source in food is the chaga mushroom.

https://jonbarron.org/herbal-library/nutraceuticals/superoxide-dismutase

http://www.worthington-biochem.com/sodbe/default.html

Curcumin increase SOD but should not be taken too long it chelates iron and can cause anemia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705117/

http://www.raysahelian.com/superoxidedismutase.html

http://www.foodtrients.com/inside/sod-do-you-know-about-this-powerful-antioxidant/

Sidt2 deficiency can inhibit autophagy. Unfortunately I have not research this Gene much.

https://www.ncbi.nlm.nih.gov/pubmed/29363559

Though I do not believe in taking enzymes the body can produce if all else fails what else are we to do. Often times taking enzymes the body can produce can disable the bodies ability to produce them.

https://empoweredsustenance.com/fat-malabsorption/

Increasing brush oder enzymes helps with malabsorption.

https://www.ncbi.nlm.nih.gov/pubmed/11346204

You must heal the endothelium to correct malabsorption. Saccharomeyces Boulardii is needed for that. This also improve lipid abosorption.

https://www.ncbi.nlm.nih.gov/pubmed/29762474

https://metabolichealing.com/villous-atrophy-leaky-gut-intestinal-dysbiosis/

Dietary nucleotide supplementation helps heal the digestive tract.

https://www.sciencedaily.com/releases/2014/04/140416143313.htm

https://www.selfhacked.com/blog/dietary-nucleotides-health-benefits-of-nucleotides/

https://www.researchgate.net/publication/275771517_Nucleotides_supplementation_improves_various_function_of_the_body

https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1440-1754.2002.00056.x

Mucins and tight junctions regulate what passes in and out of the intestines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548832/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095905/

High zonulin levels causes the gut to become more permeable.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458511/

High zonulin levels has been linked to many diseases.

https://www.mygenefood.com/zonulin-leaky-gut/

https://www.jillcarnahan.com/2013/07/14/zonulin-leaky-gut/

Probiotics to reduce zonulin.

https://www.realnatural.org/probiotics-help-reduce-intestinal-permeability-also-called-leaky-gut-syndrome/

colostrum reduces zonulin.

https://www.researchgate.net/publication/316676047_Oral_Supplementation_with_Bovine_Colostrum_Decreases_Intestinal_Permeability_and_Stool_Concentrations_of_Zonulin_in_Athletes

https://www.naturalnewsblogs.com/healing-leaky-gut/

Brush border enzymes are needed to break down and absorb food.

http://www.vivo.colostate.edu/hbooks/pathphys/digestion/smallgut/bbenzymes.html

https://www.core3training.com/can-improve-gut-overall-health/

Black Seed Oil improves carbohydrate digestion.

https://www.ncbi.nlm.nih.gov/pubmed/28959553

Thyme improves brush border enzymes.

https://www.ncbi.nlm.nih.gov/pubmed/29223554

How bile is secreted.

https://www.ncbi.nlm.nih.gov/pubmed/29262229

http://www.sophiahi.com/how-to-increase-your-digestive-fire-by-jeannie-oliver-chc-cpt/

Foods that contain natural digestive enzymes.

https://www.healthline.com/nutrition/natural-digestive-enzymes#section2

They mention Kiwi in this one. It is high oxalate so would not be good for someone who has leaky gut.

https://starmystuff.com/top-7-foods-contain-natural-digestive-enzymes

 

I am sorry these are things I forgot to post with this post. It is concerning restoring the ability to produce short chain fatty acids.

Diasccharidase in involved in our digestion and absorption of carbohydrates and sugars. If we are not producing enough then our food will sit and ferment in our upper intestine possibly feeling like a brick is sitting in our stomaches. This will cause excess gas and can lead to the production of hydroxl sulfide which inhibits sulfation and can cause issues with the CBS and BH4 pathways. This can lead to high ammonia levels, proteinuria, phenyketonuria and even porphria. Infection can cause this, an imbalance in our gut bacteria brought on by farm chemicals especially glyphosate, antibiotics, and even chemicals found in processed food. If you have diarrhea and you are not absorbing then you may be producing too much disaccaride which is an indication of high insulin levels. High oxalates will prevent the gut from healing. I have posted on oxalates and the gut. If we produce too much diasaccaride then we will experience similar symptoms only instead of being constipated we would have diarrhea.

https://drhoustonanderson.com/disaccharidase-deficiency-causes-and-treatment/

Vinegar seemed to help me but this studies shows it actually reduces Disaccharidase. Not sure what to think about this one.

https://academic.oup.com/jn/article/130/3/507/4686196

We know those with IBD usually have high insulin levels showing they have lost their sensitivity to insulin. This leads to high leptin levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159716/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959465/

I know those with IBD connot do some of these things. You have to learn to figure out what in the information that is out there you can apply and what you cannot.

https://www.healthline.com/nutrition/improve-insulin-sensitivity#section8

Though being insulin resistant is usually found in obesity it is common in many inflammatory bowel disorders.

Increasing insulin sensitivity will help with leptin levels.

https://www.marksdailyapple.com/25-ways-to-improve-your-insulin-sensitivity/

https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/

Increased insulin levels inhibits disaccharidase levels.

https://www.ncbi.nlm.nih.gov/pubmed/21946084

Decreased insulin levels increases disaccharide levels.

http://www2.ufpel.edu.br/biotecnologia/gbiotec/site/content/paginadoprofessor/uploadsprofessor/8aff603648377229ebdb3b655ecdf854.pdf

Now if you look at MAPK it is involved in IBD. So now we can see the connections. We need to increase insulin sensitivity . I read many research articles and decreasing insulin levels seem to make IBD worse but improving insulin sensitivity improved IBD. Inhibiting TNF-a improves insulin sensitivity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792822/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859792/

There are naturals that inhibit TNF-a but nothing that inhibits it directly. Also inhibiting it for too long makes us more prone to infection.

https://www.researchgate.net/profile/Solomon_Habtemariam/publication/12454244_Natural_Inhibitors_of_Tumour_Necrosis_Factor-a_Production_Secretion_and_Function/links/09e4150bb180eefd74000000/Natural-Inhibitors-of-Tumour-Necrosis-Factor-a-Production-Secretion-and-Function.pdf?origin=publication_detail

Resvertrol inhibits TNF-a it is found in grape seed extract.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091406

Reducing insulin levels reduces P38 MAPK which reduces symptoms of IBD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218950/

Those who have IBD have been found to be deficient in bacteria in the up digestive track especially Oscillospira and Akkermansia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573342/

https://helda.helsinki.fi/bitstream/handle/10138/236401/Akkermansia_muciniphila.pdf?sequence=1

Lactobacillus Fermentan increases Akkermansia.

https://www.ncbi.nlm.nih.gov/pubmed/28935567

Host microbe prebiotic and fiber interactions. Interesting lets you know how each type of saccharide effects the gut bacteria.

https://www.tandfonline.com/doi/full/10.1080/19490976.2017.1290756?src=recsys

Studies confuse me, some says stay away from carbohydrates will others show that those carbs increase the very bacteria those who have IBD are deficient in.

https://academic.oup.com/jcem/article/101/1/233/2806797

Beta Glucan found in Oats and mushrooms increases Oscillospira.

https://www.frontiersin.org/articles/10.3389/fmicb.2017.00966/full

Meditarrian diet can increase Oscillospira.

https://www.ncbi.nlm.nih.gov/pubmed/26505825

L-arginine has been found in many studies to help normalize the gut bacteria even in chickens.

https://www.ncbi.nlm.nih.gov/pubmed/28901890

Nanosilver can kill specific gut bacteria depending on the size and shape. In theory this could be used to reduce specific gut bacteria that may be too numerous.

https://www.researchgate.net/publication/241100111_Comparison_of_the_anti-bacterial_activity_on_the_nanosilver_shapes_Nanoparticles_nanorods_and_nanoplates

The shape of the silver determines which bacteria it is effective against.

https://www.ncbi.nlm.nih.gov/pubmed/28588204

Glutamine reduces Oscillospira which would be detrimental to IBS.

https://cfsremission.com/2017/10/15/decreasing-oscillospira-genus/

Black Raspberries increase Oscillospira.

https://www.ncbi.nlm.nih.gov/pubmed/29502392

Most with IBD are difficient in Oscillopira. This is found in the upper digestive tract. I believe it is the cause of the low disaccharidase production but I cannot find studies to prove it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437018/

A deficiency in Oscillopira causes food allergies.

Food additives have a negative impact on the gut.

https://www.ncbi.nlm.nih.gov/pubmed/29914144

This is a good list of bacteria and what they do. Bifidobacteria Bifidum and Breve increase short chain fatty acid production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964481/

Our gut bacteria regulate cell that produce antibiotics.

https://www.frontiersin.org/articles/10.3389/fmicb.2018.00736/full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801817/

More on Oscillopora.

https://www.datapunk.net/substrata/display.pl?119852+S

Bile acid also increases Oscillopora.

https://onlinelibrary.wiley.com/doi/abs/10.1111/1758-2229.12319

https://drjockers.com/25-ways-improve-gallbladder-health/

Gut homeostasis is controlled by the endocannbinoid system. Those with inflammatory bowel issues have been found to have low endocannbinoids. This raises diaglycerols which can prevent the proper production of digestive enzymes leading to the inability to digest and absorb saccharides and produce short chain fatty acids (carbohydrates and sugar). This is caused by the upregulation of the protein kinase pathway.

https://www.ncbi.nlm.nih.gov/pubmed/22917662

Black pepper increases endocannbinoids which would help with IBD.

https://www.ncbi.nlm.nih.gov/pubmed/24412246

HSP70 is a transport for anamide and other endocannabinoids. I have posted on HSP70.

FAAH inibitors increase endocannabinoids.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882713/

Biochanin A found in read clover, the red covering on peanuts, and in chick peas is an FAAH inhibitor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931556/

Here is information on other cannabinoids and their effects on the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429335/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538700/

Kaempferol found in pine tree bark extract and magnolia is an FAAH inhibitor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538700/

Bilirubin is inhibited with IBD and other inflammatory bile diseases. This is cause by the inflammation which can lead to scarring and obstruction of biliary ducts. Serrapeptase helps remove scar tissue and so doe HSP70. Also using anti-inflammatory herbs helps.

http://www.crohnscolitisfoundation.org/resources/liver-disease-and-ibd.html

https://inflammatoryboweldisease.net/symptoms/complications/gallstones/

https://kresserinstitute.com/little-known-connection-leaky-gut-gluten-intolerance-gallbladder-problems/

This is the oddest part about IBD and other inflammatory diseases. TMAO is low in those who have an intestinal inflammatory disease. Most have too much of the bacteria that produces TMAO but those with IBD have too few.

https://www.ncbi.nlm.nih.gov/pubmed/26160437

This is a list of gut bacteria that increase TMAO consuming choline will increase these bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453578/

https://lpi.oregonstate.edu/mic/other-nutrients/choline

https://draxe.com/what-is-choline/

Faecalibacterium Prausnitzii has been found to be low in those with inflammatory bowel disease. This causes a dificiency in nicotinic acid which leads to an increase in phenylalamine. This lead to a conditions called phenyketonuria which causes high ammonia levels in the body and can effect many metabolic pathways and cause us to become ill when we eat meat, potatoes or anything else that has phenylalanine in it. A deficiency in Faicalibacterium Prausnitzii also results in high cadaverine and putrescine levels which causes inflammation.

https://emedicine.medscape.com/article/945180-overview?pa=70SvUf61EZjJeh01GcM07cjK0CdaeXT%2FVguJkgES6Vuf4MsXKJuI2VMwKp69ZMinm%2BKlpX80V6KaHMrB8SW%2FFlaycSibeA0Q%2FJsWK%2BpGHzs%3D

https://www.healthline.com/health/phenylketonuria

Our gut bacteria need iron tho thrive but the iron they fortify food with is the wrong type. Iron found in curly dock and burdock root will supply you with iron without causing toxicity unless you have certain liver diseases. If you have iron toxicity lactoferrin will restore iron homeostasis. Curcumine will reduce iron levels in the blood also but do not take it too long or you can become anemic.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491036/

Ghrelin stimulates our appetite and increase stomach acid.

https://www.theunion.com/news/twi/glyphosate-roundup-and-its-link-to-celiac-disease-gluten-intolerance/

Fatty acid and vagus nerve stimulate ghrelin.

https://academic.oup.com/abbs/article/41/3/188/655

https://www.ncbi.nlm.nih.gov/pubmed/29632576

https://www.selfhacked.com/blog/32-ways-to-stimulate-your-vagus-nerve-and-all-you-need-to-know-about-it/

https://thelivingproofinstitute.com/19-ways-to-stimulate-your-vagus-nerve/

https://www.psychologytoday.com/us/blog/the-athletes-way/201607/vagus-nerve-stimulation-dramatically-reduces-inflammation

I had to alternate types of diets until I got things straightened out. I had to do a FODMAP diet first then as I healed I had to switch to a Paleo diet. Then when I had healed enough I was able to fast it took me a while to build up to being able to fast for a day. Some can go longer and it is dangerous for others like those with lysosomal storage issues.

https://paleoleap.com/butyrate-anti-inflammatory-fat/

Hydrogen Sulfide produced by gut bacteria can cause sulfation issues.

https://sibosurvivor.com/hydrogen-sulfide-sibo/

When we have too much hydrogen sulfide being produce by our gut microbiome it will cause us to become constipated.

 https://www.ncbi.nlm.nih.gov/pubmed/28971603

https://www.sciencedirect.com/science/article/pii/S2213007117300485

now you have reached a state that has caused a cycle that is hard to break and results in ulcerative coalititis and even IBS.

 https://link.springer.com/article/10.1023/A:1018867516575

Excess H2S causes low blood pressure and a reduced body temperature. It will slow our metabolism causing us to feel drowsy.

http://www.ei-resource.org/…/gut-bacteria-the-hydrogen…/

The inhibited phosphorylation causes a deficiency in the redox ions needed by many metabloic pathways. Mainly Mg2+, Mn2+, Zn2+ and indirectly Ca2+. So it pretty much shuts cellular function down.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010430/

Not all will get drowsy with the inhibited phosphorylation it may cause NMDA issues which is what happened to me. When this happens and your glutamate levels sky rocket it will fell like your head is going to spit open, you will not be able to sleep and you will experience anxiety.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966912/

This thread is long enough but the can effect the CBS and BH4 pathways which can lead to sulfur intolerance and meat intolerance. Even after correcting this problem you have to heal the gut and get the oxalates down to restore the function of the metabolic pathways.

http://www.talkingaboutthescience.com/studies/Donohue-Sulfoxidation.pdf

Having to many H2S producing bacteria has been shown to raise blood levels of H2S. I could not find studies on the prolonged effects but I have found information on prolonged exposure. It causes sulfhemoglobin which cannot be broken down by the body.

http://www.theijoem.com/ijoem/index.php/ijoem/article/view/482

https://www.ncbi.nlm.nih.gov/pubmed/25237136

https://www.frontiersin.org/articles/10.3389/fped.2018.00098/full

Thiamine and B6 deficiency can cause high oxalates.

https://www.ncbi.nlm.nih.gov/pubmed/3947375

https://draxe.com/thiamine-foods/

the gut and cholestokinin

http://www.yourhormones.info/hormones/cholecystokinin/

https://www.selfhacked.com/blog/good-bad-effects-cck/

Trypsin inhibitors increase cholecystokinin.

https://naldc.nal.usda.gov/download/26115/PDF

Things that raise GABA like , mugwort, wormwood and rooibos reduces cholecystokinin levels. High estrogen levels cause high cholecystokinin levels. High dopamine levels increases cholecystokinin. High levels of cholecystokinin causes glutamate toxicity and NMDA toxicity.

https://www.acnp.org/g4/GN401000056/CH056.html

Potatoes increase cholecystokinin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033477/

If not addressed it leads to autism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628252/

Proprionate is high in Ibs. This strikes me as odd because acetate and butyrate are low in IBS. How can one short chain fatty acid be high and the test dificient?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847229/

https://www.healthline.com/nutrition/short-chain-fatty-acids-101#section1

High proprionate can cause loss of appetite and weight loss.

https://gut.bmj.com/content/64/11/1744

it is from having to high of bacteroides.

https://jb.asm.org/content/jb/134/1/84.full.pdf

This article partially explains the high bacteroides levels.

http://humanfoodproject.com/going-feral-one-year-journey-acquire-healthiest-gut-microbiome-world-heard/

Meat increases bacteriodes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820228/

meat alkalizes the gut so it makes sense that those with IBD may consume more meat which will make them have raised bacteroides levels. This can lead to many health problems.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949257/

Betaine reduces bacteriodes by increasing stomach acid.

https://www.selfhacked.com/blog/tmg-health-benefits/

http://drlwilson.com/articles/TRIMTHYLGLYCINE.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176045/

Snail1 involvement in inflammatory bowel diseases indicates macrophagy issues.

https://www.ncbi.nlm.nih.gov/pubmed/21830269

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0450-z

Macrophagy issue also cause lipogenesis issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108423/

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0450-z

Glycolysis issues are also an indication of inhibited macrophagy and sure enough those with inflammatory bowel disorders have glycolysis issues.

https://onlinelibrary.wiley.com/doi/abs/10.1002/ibd.21388

Macrophagy genes have been impicated in inflammatory bowel disease.

http://www.els.net/WileyCDA/ElsArticle/refId-a0025006.html

Good information from my friend David Anderson.

For people with digestive issues

Hydrophilic colloidal diet

1. Hydrophilic colloids bring about conditions in the stomach during digestion which approach those resulting from the consumption of foods in their natural state.

2.Hydrophilic colloids lessen gastric irritation by absorbing the digestive secretions of the stomach so that digestion takes place within a mass of food.

3. Gelatin, because of its availability, relatively low cost, non-toxicity, adaptability as an item of dietary and its thorough digestibility becomes an admirable hydrophilic colloid for dietary usage.

4. The amount of gelatin to be used in a given case depends on the patient’s needs, but it must be of good quality and sufficient in amount.

5. It has a wide range of usefulness in gastrointestinal ailments ranging from the atonic conditions met in the chronic invalid to the irritating condition presented in gastric ulcer.

In some instances, gelatinized arrowroot powder has been used to achieve similar results.. Arrowroot/pectin, etc… Could possibly be used if oxalates are an issue.

 

https://link.springer.com/article/10.1007%2FBF03010602

 

Medium chain triglycerides improve bile flow and decrease bile reabsorption.

https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2014/06/Parrish-February-17.pdf

https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-018-0267-x

MCTs help heal leaky gut and inflammatory bowel disorders.

https://www.ncbi.nlm.nih.gov/pubmed/27187452

https://www.frontiersin.org/articles/10.3389/fimmu.2016.00290/full

Organic acids help heal the gut mucosa.

https://www.researchgate.net/profile/Ulker_Eren2/publication/282700134_Effects_of_dietary_organic_acid_supplementation_on_the_intestinal_mucosa_in_broilers/links/5649b1d908ae451880af661a/Effects-of-dietary-organic-acid-supplementation-on-the-intestinal-mucosa-in-broilers.pdf?origin=publication_detail

http://www.mdpi.com/2072-6643/9/9/920/pdf

file:///home/homuser/Downloads/nutrients-09-00920.pdf

They recommend glutamate in this. That is not correct because those with inflammatory bowel issues have high bacteriodes and glutamate feeds them which can make things worse. But there is useful information in this.

There is an error in this. Those with inflammatory bowel have high bacteroides which causes a lot of problems. They claim glutamate helps but it feeds bacteroides so would make things worse but I found useful information in this.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622680/

Interesting information on inflammatory bowel disease.

https://www.hindawi.com/journals/mi/2017/6869259/

Those with inflammatory bowel issues are low in biotin which is probably caused by the inflammation inhibiting absorption.

https://europepmc.org/abstract/med/19056639

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129763/

A biotin deficiency causes the inability to break down proteins, fats and other nutrients.

https://www.physiology.org/doi/abs/10.1152/ajpcell.00141.2016

Those with inflammatory bowel usually have low biotin which can cause many metabolic issues. Biotin needs Adenosylcobalamin which is a form of B12 in the body. Some may have to supplement if the body is not converting it.

Adenosylcobalamin helps with biotin absorption and use.

https://www.globalhealingcenter.com/natural-health/adenosylcobalamin-4-facts-know/

Biotin and pantothenic acid compete for absorption and pantothenic acid can inhibit biotin absorption.

https://www.ncbi.nlm.nih.gov/pubmed/9814986

Alkaline Phosphotase is low in those with inflammatory bowel disorders. Lactobacillus Casei increases it and will help with nutrient absorption.

https://www.ncbi.nlm.nih.gov/pubmed/22783049

Before increasing it make sure you know the dangers of too much.

https://www.selfhacked.com/blog/alkaline-phosphatase/

How to increase ALP.

https://health.onehowto.com/article/how-to-increase-alkaline-phosphatase-11707.html

http://www.newhealthguide.org/Low-Alkaline-Phosphatase.html

If you take curcumin once the gut bacteria start getting established stop taking it. It can cause anemia because it chelates iron.

https://www.ncbi.nlm.nih.gov/pubmed/25474287

Cissus stimulates ALP.

https://www.ncbi.nlm.nih.gov/pubmed/25449449

https://examine.com/supplements/cissus-quadrangularis/

High estrogen levels effect bile production. Bile protects the intestines from inflamation.

https://hormonesbalance.com/articles/gallbladder-hormone-balance-connection-mean-dont-gallbladder/

Hormones involved with bile flow.

https://hormonesbalance.com/articles/gallbladder-hormone-balance-connection-mean-dont-gallbladder/

Inhibited bile flow can cause estrogen dominance.

http://www.jbc.org/content/early/2018/06/21/jbc.RA118.001789.full.pdf

This causes a cycle that is hard to break and results in high cck levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756670/

Activation of the CCK1 receptor by estrogen can lead to gall stones.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037422/

Dim3 (diinoylmethane) inhibits the estrogen receptor which should lower cholestokinin levels.

https://www.ncbi.nlm.nih.gov/pubmed/25486199

http://joe.endocrinology-journals.org/content/195/3/393.full.pdf

Things that inhibit Era.

https://www.hindawi.com/journals/omcl/2018/6040149/

They mentioned soy isoflavons in the previous study but it could make things worse.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633874/

ursolid acid that was mentioned is found in the wax on skins of apples , in rosemary and thyme.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379974/

 

These are enzymes and hormones that are usually dis-regulated in inflammatory bowel.

Cholesterols function in bile secretion. Issues with the liver X receptor can cause issues with cholesterol metabolism.

http://www.jbc.org/content/278/18/15565.long

https://www.ncbi.nlm.nih.gov/pubmed/29523554

Olive Oil help resolve liver X receptor issues. But inhibits glucuronidation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521785/

Butyrate found in butter and ghee also help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111843/

High estrogen inhibits sulfation. Increasing UDP-glucuronosyltransferases will reduce estrogen levels.

http://www.jbc.org/content/275/46/36164.full.pdf

http://dmd.aspetjournals.org/content/30/5/564

DHA, oleic acid, and linoleic acid inhibit those enzymes.

https://www.nature.com/articles/srep02903

Foods that increase UDP-glucuronosyltransferase.

http://dmd.aspetjournals.org/content/30/5/564

https://www.heart-health-guide.com/apigenin.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874462/

https://www.selfhacked.com/blog/apigenin-top-11-science-based-health-benefits-apigenin/

Luteiolin is good at increasing UDP-glucuronosyltransferase.

http://secretsofnaturalhealing.blogspot.com/2010/12/luteolin-rich-foods-shown-to-reduce.html

https://www.selfhacked.com/blog/top-11-science-based-health-benefits-luteolin/

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166239

Diosmetin is found in the white parts of citris fruit and dates.

https://pubs.acs.org/doi/abs/10.1021/jf502359x?src=recsys&journalCode=jafcau

https://www.researchgate.net/publication/228115816_Bioactivity_of_Diosmetin_Glycosides_Isolated_from_the_Epicarp_of_Date_Fruits_Phoenix_dactylifera_on_the_Biochemical_Profile_of_Alloxan_Diabetic_Male_Rats

 

 

 

 

 

Leaky Gut, Oxalates and more supplement information.

This is not medical advice and should not be taken as such. I am posting this for educational and informational purposes.

Avoid GMOs they cause leaky gut and gut dysbiosis. If you do not know about them read my post on them. They and the chemicals used on them cause oxalates which I mention later in this article. They kill our good gut microbes. This is a list of gut microbiota and what conditions they help with.

Mucilage every few hours helps a lot with leaky gut. When you have leaky gut it causes high oxalate levels. This causes a cycle that is hard to break because oxalates prevent the gut from healing. Mucilage can help heal the gut breaking the cycle. Mucilage helped me the most with healing my gut.

Things that are high in mucilage are Okra, organic Oatmeal, Aloe Vera I found the liquid gel worked the best dried aloe vera seemed ineffective. Besella Alba known as Malabar Spinach, Irish moss but you have to watch consuming it, it has a cannabinoid that reduces pain but has side effects if you consume too much. Most plants in the mallow family are very high in mucilage and have very good healing properties. Most plants in the dioscera family are high in mucilage especially the chinese wild yam. Fenugreek is high in mucilage. Flax seeds are high mucilage but if you have leaky gut they should be ground up to prevent other heath issues. Most seaweeds are high in mucilage. Licorice root is high mucilage but you have to make sure it is deglycyrrhizinated if not it can cause many health problems. Mullein is high mucilage and helps with lung infections. Most edible plants in the daisy and sunflower family are high in mucilage. Wild Daisy helped me a lot. Pysillium seed husk are high in mucilage they are seeds from the plantain herb. Plantain herb itself is very high in mucilage. Wild violet is very high in mucilage. Chia seed is high in mucilage most seed is. Slippery Elm is high in mucilage but some claim it is high oxalate , I have never tried it. Most roots herbs are high in mucilage. Arrow root is very high in mucilage.

https://mavcure.com/mucilaginous-herbs/

https://www.invitehealth.com/article-demulcents-and-mucilages-true-healers.html

Probiotic Guide.

Do not get discouraged your gut can heal but it may take time.

https://www.prevention.com/health/a20469183/leaky-gut-syndrome/

If we do not correct it , it can lead to many health problems.

http://www.beyondmthfr.com/category/home-slider/

Leaky gut can lead to food allergies and chronic illness.

https://draxe.com/leaky-gut-test/

If you have been damaged by GMOs or antibiotics and have gut dysbiois and it feels like you have a brick in your gut after you eat, you may not be producing enough intrinsic factor which is needed in order for your body to absorb vitamin B12.  A deficiency in B12 causes many serious health problems. These are some things that may increase intrinsic factor.

http://www.sophiahi.com/how-to-increase-your-digestive-fire-by-jeannie-oliver-chc-cpt/

We need to avoid Omega 6 oils. Most of that comes from corn oil,soy bean oil, vegetable oil, and lard. Most of those are from GMOs also. They will cause inflammation in the body if we get too much.

Probiotics are one of the keys to healing the gut. They should be geared to what health issues we are dealing with.

http://www.myleakygutsyndrome.com/probiotics-for-leaky-gut-how-probiotics-can-heal-your-leaky-gut/

NSAIDs can damage the gut if taken for too long which can lead to many forms of chronic illness.

https://jeffreydachmd.com/2014/06/nsaids-small-bowel-leaky-gut/

Healing Leaky Gut

It is very important to

If you have Lyme there is very little knowledge in the medical community to assist with healing and fighting the disease it and other infections can raise zonulin levels causing leaky gut.. There are a few elite doctors who cared enough to do their own research. This is not medical advice. I am posting this to enable people to find the things they need to research to aid in their own healing. Always let your doctor know if you have any diet changes or you take any supplements. Always listen to your body, because it will tell you what is good for it and what is not. When you make any diet changes, whether it is supplements or food, only make one or two changes at a time so that if you have a reaction you will be able to identify what the cause of the problem is.

When you have leaky gut food particles can get into your blood stream which will raise your histamine levels. Signs of raised histamine levels are burning skin , headaches, confusion, fatigue, muscle spasms, blocked urinary track. The list goes on and on so it is very important to get the gut healed or you cannot fight infection or heal.

Healing the Gut

If you have any digestive problems you must take care of those first. Everything is tied to the digestive tract, even the brain. Problems with digestion can lead to a domino effect leading to trouble with hormones, bladder, liver the cardiovascular system, autoimmune system, and even mental health. If you do not get digestive problems taken care of you are fighting a losing battle whatever else you do.

Primary to getting the gut to heal is avoiding foods containing GMOs. They have been shown to damage the digestive system, among other issues.

If you are fighting an infection or dysbiosis the die off can cause bloating. I had to ease into things so I did not bloat too bad. Many probiotics can cause die off of pathogens and some of the bad gut bacteria which will also cause bloating.

Liquid Aloe Vera — this coats the stomach and helps it heal. It has also been shown to fight Candida and H-Pylori when they have switched from commensal to pathogenic forms. Has been shown to reduce oxalates.

Mucilage helps heal the gut. Some wild plants are high in mucilage like Wild Violets and Dandelion, the roots of Evening Primrose are high in mucilage. Plants in the mallow family are high in mucilage. Marshmallow root has many healing properties. The plants with the highest mucilage content are Spinach Vine, Irish Moss, Wild Yam, Fenugreek, Crushed Flax seed, Kelp, Marshmallow Root, Mullein, Okra, Psylium husk which is from the seeds of plantain herb, chia seeds and Broad Leaf Plantain herb. Some may have oxalates but we cannot avoid oxalates we need to address the issues causing high oxalates. Almost all foods have oxalates, cooking breaks down oxalates. But avoiding oxalates entirely will cause you more health problems then it would cure.

Mastic Gum — coats the stomach and has also been shown to fight many pathogens. This is

dried sap from the mastic tree and can be found in health food stores. Coating the stomachache is very important. I know mucilage can inhibit nutrient absorption but you cannot heal if you do not coat your stomach.

Biofilms

This is a list of things that break biofilms or aid the gut in healing. When the biofilms break up you will defecate mucous for about a month sometimes it will appear as if it is a piece of your intestine. I found that very scary and had to ask people who have went through it what it was. There is no information I could find to explain it. Breaking Biofilms is very important in healing our gut if our gut issues are from an infection..

Propolis — a resin produced by bees, so anyone with allergies to bees should not use this one. It has been shown to bust biofilms, kill many pathogens, and to promote gut healing.

Pepto-Bismol — I kept this on hand for when the aloe vera didn’t seem to help. You have to be careful you can herx from this because bismuth kills many pathogens. Bismuth has been shown to also break up biofilms.

phospholipids (good fats) – omega 3s are the best to use. Oils like grape seed oil, sesame seed oil , olive oil contain omaega 3s. Try avoiding Omega 6 it is needed by the body but if we get too much it can cause inflammation.

Garlic- garlic has many healing properties along with breaking up biofilms a killing pathogens. If you have high sulfite levels from having too many sulfur digesting bacteria this will make you ill because it is high sulfur and will raise your sulfite levels. I had this problem but one of the most potent chemicals in garlic is allicin and it does not cause issues with sulfites. I used it and it worked very well for me.

Stevia- it has to be Stevia extract because it needs the cofactors to work. Make sure you get organic because there is GMO Stevia. It also kills many pathogens including Lyme.

Xylitol-has very potent antibiotic properties. Many get cramps when they use it. I got cramps but I had an infected tooth and it worked very well for taking the infection out.

Cinnamon – breaks biofilms, high in mucilage coats the stomachache and helps with nausea. It has been shown to inhibit pain.

Cholesterol breaks biofilms is needed by almost all cells in the body. The brain and heart cannot function without it. Oxidative stress from leaky gut can cause high oxLDL. If you avoid cholesterol because of that you will be inhibiting your bodies ability to heal. When you reduce the source of the oxidative stress your oxLDL will return to normal. Cholesterol is an antioxidant and is used by the body to protect cells from pathogens. Cholesterol is needed to maintain the integrity of the digestive system and bladder.

Chlorophyll – fights Candida, helps remove toxins such as heavy metals from the body, and improves the health of our blood, as well as to protect the good bacteria. Sources of chlorophyll include green leafy vegetables and seaweed, but make sure the seaweed has come from a non-contaminated source. You can purchase liquid chlorophyll. I only used it for about a week and then I backed off to three times a week. There are many health benefits to liquid chlorophyll. It raises oxygen levels in the blood and restores the ph of our bladder and digestive system. It fights many pathogens. It feeds the good gut bacteria while reducing the bad. Those with SIBO will bloat when using this and herx from the die off of the sulfur digesting and methane producing bacteria. If you have SIBO and are going to use chlorophyll I would ease into using it. Liquid chlorophyll also raises oxygen levels in the body and helps restore the health of our blood cells.

Apple cider vinegar – helps fight Candida, breaks up biofilms and kills pain better then aspiron.

Mushrooms — bust biofilms, kill Candida, and fight many other diseases. Most mushrooms will do this. Mushrooms also contain glycoproteins which improve the bodies cell to cell communication so you can heal quicker. Glycoproteins also kill many pathogens so you could herx from them. Mushrooms also contain Beta Glucan which helps restore the good gut bacteria and fights pathogens.

Coconut oil — breaks biofilms and kills pathogens. It can even cross the blood brain barrier and improves brain health. The body converts coconut oil’s lauric acid to monolauren, which has been shown to fight many pathogens, reduce the number of Lyme spyrochetes in Lyme sufferers, and also crosses the blood brain barrier to contribute to improved brain health. Coconut oil contains many of the electrolytes needed by the body. When ill you need more electrolytes then usual.

Bromelain – breaks up biofilms helps fight pathogens , helps with digestion and reduces ammonia in the body.

Flax seed oil — breaks biofilms and fights pathogens. It has Omega-3 fatty acids which help protect the digestive system. Do not use too much flax seed and alternate the days you take it. Taking too much seems to cancel out its health benefits. Also has a canibinoid similar to thc so it reduces pain.

Inulin — promotes healthy bacteria in the digestive system, aiding in the break down and absorption of nutrients. Some sources of inulin are onions, garlic, bananas, dandelion root, chicory root, Jerusalem artichoke, asparagus, barley.

Oxalates.

Symptoms of high oxalates is joint pain, mental fog, anxiety , depression, kidney and liver pain, muscle fatigue, digestive pain, bladder pain, vulvodynia, indigestion when foods containing oxalates are consumed, and skin rashes. Many things can cause oxalates. Metabolic issues, leaky gut, high histamines, gut dysbiosis which cause there to be too many sulfur digesting and methane producing bacteria, which cause high sulfite level and high hydroxy radical levels which result in oxidative stress which also causes oxalates. Toxins such as glyphosate, glufosinate and many other farm chemicals. Also heavy metals, endotoxins, and alfoxins can cause oxalates to form. 

https://www.greatplainslaboratory.com/articles-1/2015/11/13/oxalates-control-is-a-major-new-factor-in-autism-therapy

http://www.lowoxalate.info/research.html

http://bioindividualnutrition.com/oxalates-their-influence-on-chronic-disease/

Oxalates break down when cooked so foods that are high in oxalates like spinach make sure you cook before eating. We cannot avoid oxalates they are in most food.

Oxalates prevent the body from healing and also hinder the gut from healing. That becomes a viscous cycle because when you have leaky gut you will develop high histamines and toxins can easily enter the blood stream, those also cause oxalates. Endotoxins and Afloxin can also cause oxalates. So it is very important to detox. Also metablolic issues and high sulfite levels can cause high oxalates so those should be addressed before detoxing. High sulfite levels can be caused from having too many sulfur digesting bacteria (gut dysbiosis). That in itself will cause many health issues like high ammonia levels. You can heal the gut with high oxalate levels but you must consume a lot of high mucilage foods to coat and protect the gut.

Here is a list of some things that reduce oxalates. I will post some links to some information also. 

https://chriskresser.com/how-to-prevent-kidney-stones-naturally/

http://www.beyondmthfr.com/oxalates-and-mthfr-understanding-the-gut-kidney-axis/

Oxalates cause inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807999/

We have gut bacteria that breaks down oxalates. If we are deficient in them it will raise our oxalate levels. They need the other friendly gut microbiome to establish. If we are lacking in the other gut bacteria they will not establish when we take them. They require an oligosaccharide to get established and remain in the gut. The also need sugar the type found in fruit , honey, or maple syrup will help them establish.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235702/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300851/

Oxalobacter Formingene

Bififobacterium Adolescentis

Bifidobacteriium Anamalis

Lactobacillus Acidophilus

Lactobacillus Gasseri

Lactobacillus Rhamnosus

Lactobacillus Planatarum

Enterococcus Faecalis reduces oxalates but consuming to much salt inhibits it’s ability to degrade oxalates.

Make sure you drink plenty of water. It needs to be free of chlorine or flouride because they cause oxalates and are very toxic to the body.

Avoid artificial sweeteners and processed sugar they can cause oxalates.

Sodium bicarbonate- be careful do not use more then a tablespoon in a glass of water it is a very strong base which means in high amounts it can cause burns. I only took it about 3 times a week.

Citric Acid which is not vitamin C helps reduce oxalates. Lemon juice is a good source of citric acid. It irritated my gut if I used it straight so I put it in my water with a little honey.

Do not take calcium get it from natural sources , calcium reduces oxalates but the calcium found in many supplements is the wrong type and can cause oxalates. Stinging nettles is one of the best sources of calcium. Most foods contain adequate amounts of calcium. If someone has bone loss it is usually from a magnesium or silica deficiency.

Excess salt causes oxalates. I use sea salt. Studies have found using sea salt cuts the craving for salt because of the trace minerals it contains.

Magnesium Citrate reduces oxalates. Also there are many metabolic pathways that need magnesium. When they do not have the nutrients they need oxalates can be produced.

Phytic acid found in grains can cause oxalates. We need phytic acid but should limit our intake of grains.

Foods that raise histamines like fermented foods, aged meats and some cheeses, also yogurt. High histamine levels can cause oxalates.

Vitamin B6 reduces oxalates, I had to use P5P because I wasn’t converting B6/

Vitamin E reduces oxalates. Most seeds contain vitamin E. If you eat flax seeds they have to be crushed or you will not digest them. Avocados are high in vitamin E. Also Olive oil is high in vitamin E. Mango and hazel nuts .

NAC N-Acetyl Cysteine reduces oxalates.

https://www.tandfonline.com/doi/abs/10.1080/10715762.2016.1221507?journalCode=ifra20

Aloe Vera has been shown to reduce oxalates.

Thiamine deficiency can cause high oxalates.

https://alobar.livejournal.com/2510679.html

Do not take more then 4000 IU of vitamin D it can cause oxaltes in very high doses.

https://www.ncbi.nlm.nih.gov/pubmed/8382134

Vitamin D in the correct amounts actually reduces oxalalates. There is a saying the poison is in the dose. I often find that to be true.

https://www.ncbi.nlm.nih.gov/pubmed/19734276

The flavonoids found in the white part of citrus fruits will reduce oxalates.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616898/

Eating too much meat can cause oxalates to form. mainly in those with metabolic issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1455427/

Spirulina reduces oxalates but some with high sulfite levels may have trouble with it. I can take it now but it did make me worse because it is high in sulfur.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972226/

http://redmountainclinic.com/the-down-side-to-high-oxalates-problems-with-sulfate-b6-gut-and-methylation/

We need vitamin C to heal. Ester-C has been shown to actually reduce oxalates and can usually be taken by those with interstitial cystitis.

If you have excess oxidative stress it can cause oxalates to form so it must be addressed.

Molybdenum helps reduce ammonia which can cause oxidative stress. Do not take too much it can be toxic if it get to high in our bodies. Many metabolic pathways need it but we do not want to overload on it.

Oxidative stress and oxalates.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788594/

Diet changes

https://www.rebootwithjoe.com/oxalates-kidney-stones-what-you-should-know/

Sulfation and oxalates.

http://www.beyondmthfr.com/side-high-oxalates-problems-sulfate-b6-gut-methylation/

Herbs for Healing

salsify, and burdock root. Some people are allergic to foods that contain inulin. Most foods that contain fiber that is hard to digest will help balance and protect the good gut bacteria. The allergic reaction is most likely a herx reaction and not an allergic reaction.

Acanthus Ilicifolius – increases production of osteoblast which are necessary for bone growth and health. Has been shown to help gastric ulcers heal. Has strong antibacterial and antifungal properties.

Embilia Ribes (False Black Pepper) — helps with flatulence, kills parasites, decreases homocysteine levels, and reduces symptoms of brain disorders. Lowering homocysteine levels would help with allergies and mast cell activation syndrome.

Pectin — breaks biofilms and lowers bad cholesterol. Pectin is a type of fiber. Food sources include apricots, peaches, apples, bananas, oranges, grapes, carrots, tomatoes and white potatoes.

Phospholipids — protect the digestive system, promote healing, and protect against cancer and infections. Some sources of phospholipids are butter, ghee, and mercury-free fish oil.

Butyric acid — protects our digestive system from infection, protects the body from cancer, aids in breaking food down into smaller particles that are easier for our bodies to absorb and make use of the nutrients. Butyric acid is produced when we consume hard to digest fiber, such as that in celery. It can also be found in ghee and butter.Also some of our microbiome produce this from fiber we consume.

Clove oil — has been shown to fight many pathogens and settles your stomach. This one really helped me because I was having trouble eating due to the nausea from my leaky gut.

Restoring Gut bacteria.

Probiotics — help restore the good bacteria to our digestive system, fight pathogens, and break down our foods. Choose a probiotic supplement with Bifidus and active Acidophilus cultures – the higher the number of cultures the better. The important gut bacteria to get is B Lactis , L Acidophilus, L Rhamnosus , L Salivarius, L Plantarum , B Animalis, B Longus, B Brevi, B Infantis.

Avoid things that contain Lactobaccilus Casei, L Lactis, L Reuteri, L Fermentum/Fermenti, L Paracaei, L Faecum , L Bulgaricus, Streptococcus Thermophilus.

If you start feeling bloated you may be getting to many good gut bacteria which can cause harm also. Get lots of prebiotics it feeds and protects the good gut bacteria and balances it out. Happy gut bacteria will help protect your immune system and help rebuild it.

Fireweed – Helps normalize gut flora, supports the good gut bacteria. Reduces inflammation and symptoms of irritable bowel syndrome. High in mucilage which heals the gut.

Bone broth — helps leaky gut and has the added benefit of containing many nutrients. If you have high sulfite levels or sufation issues you will need to address them before using this. It is high in glutamate and those issues can cause high glutamate levels which will cause very bad headaches and brain fog.

L-Glutamine — helps heal the soft tissue in the gut and is involved in many metabolic processes, fueling white blood cells and many other cells. Unfortunately, animal flesh is the best source of L-glutamine. I say unfortunately because if you have methylation problems digesting meat may be difficult for you. Whey protein and other dairy products are high in L-glutamine, as are eggs, nuts, seeds, lentils and other legumes, but all contain phenylalanine, which can also create problems if you are not methylating right.

I take betaine (trimethylglycine), derived from beets, to aid with the methylation. It has helped me I now rarely get ill when eating things that contain phenylalanine. Bromelain and papaya enzymes are also supposed to help with methylation. Cabbage is a good source of L-glutamine. If you have a blocked or upregualted CBS pathway , or an upregulated BH4 pathway and don’t address it this could make you ill. Most with those issues would benefit from taking P5P, selenium, and magnesium citrate. Also three times a week molybdenum and manganese.

If the pathways for using phenylalanine is blocked then foods high in phenylalanine will raise your ammonia levels and histamine levels which in turn can give you phenylaturia or homocysteinuria. Phenylaturia causes high ammonia levels which alkalize the digestive system and bladder making us prone to infection and dysbiosis. Protease enzymes may help with that. Meat is high in phenylalanine if you get ill after eating meat then you may have a problem.

If you eat foods that raise your glutathione levels like cruciferous vegetables then you may have a CBS pathway blocked which can make you feel ill. What helped me with that was P5P, Methylcolobamine and Molybdenum which I only take a few times a week.

— Avoid things high in tannic acid, such as coffee.

— Do not drink alcohol.

— Many things in processed foods can cause leaky gut, so try to eat foods made from whole, fresh ingredients.

Processed Sugar causes inflammation so try your best to avoid it in all its forms. Other sugars like those found in fruits, honey, organic black strap molasses have been found to fight pathogens and actually promote healing.

Lowering Histamine levels. Leaky gut causes high histamine levels which causes a loop that prevents us from healing because histamines cause inflammation.

Avoid foods high in histamines especially fermented foods, cheese and yogurt. Also avoid aged meats. Everyone is different, some can eat one high histamine food and not another and vice versa.

Things that help lower histamine levels. There are many protease enzyme that help with that I used Bromelain and Betaine along with serrapeptase because it helps dissolve scar tissue caused by chronic disease and also lowers histamine levels. Be careful even those protease enzymes are good for lowering histamine and homocysteine levels if taken to often it can lower your homocysteine levels too low.

Other protease enzyme that are supposed to work well like Papain and Nattokinase I have never tried them. Nattokinase is supposed to help with renal and lymph blockages. Nattokinase is supposed to help reduce carcinogenic estrogen levels.

American Skullcap Tea – not to be confused with chinese which has different health benefits. American Skullcap promotes relaxation, reduces seizures, inhibits food allergies. Has amazing healing abilities. I did experience problems with this at first because it improve the health of blood vessels and helps repair nerves. When I started to heal my nerves and muscles woke up and all heck broke loose. I had bad charlie horuses and burning in my nerves for three days but once my body got used to them working again it was like a big weight was lifted off and I could feel myself healing.

Wasabi – reduces risk of cancer and heart disease, has anti-inflammatory properties. Helps fight bacterial infections. It also reduces allergy symptoms and detoxes the body. Wasabi is packed full of nutrients.

Detoxing

Luffa Gourd – Strengthens the immune system, reduces fevers, detoxifies the body and aids the body with hydration. Has been shown to reduce heart palpitations and hair loss.

Oregano Oil – contains Carvacrol which protects the liver, has been shown to inhibit cancer growth. Works as a good nontoxic disinfectant. Has been shown to be as affective as chlorine. It kills Candida and helps protect the cardiovascular system from LDL and reduces inflammation.

Kills many pathogens.

Carnosine – detoxes the bodies cells of heavy metals has been shown to reduce some aging. Good sources are avocados, beans, bran, brewers yeast, brown rice, nuts, seeds, watercress, and spirulina.

L-ornithine and arginine is needed in the urea cycle to remove ammonia and other toxins from the body. Good sources of these are legumes,vegetables,nuts, seafood and seeds.

Indian Paintbrush (Castilleja) Only the flowers are eaten, the rest of the plant is too high in selenium. Has similar health benefits as garlic. It enhances the immune system. Helps the body to detox, the rest of the plant is too high in selenium to consume.

Garlic , Dandelion Tea, Red Rooibos Tea, Chlorophyll and Rattan tea are all good at detoxing the body. The protease enzymes also help with detoxing.

Lemmongrass – Lowers LDL, helps get toxins out of the body and lowers uric acid levels. Has been shown to be affective against cancer.

The essential oil has antimicrobial properties and has been shown to be affective against H-Pylori. Has also been shown to aid colitis. Calms muscles and nerves Helps relive pain including headaches. Has been shown to reduce the occurrence of convulsions and helps repair the immune system.!!Be careful some have had an allergic reaction to this.!!

White Peony Root – reduces diabetes induced oxidative stress. Decreases urinary albumin. Protects the liver from oxidative stress. RDA is 100 to 200 mg per kilogram of weight.

These are things that helped me heal.

Research them to see if they would help you.

Silymarin- milk thistle, heals cell damage helps repair methylation pathways. Helps repair nerve damage. I have heard complaints of this making people ill this is because certain liver disease can cause high iron levels and milk thistle is high in iron.

Kelp – has iodine which is needed by the body to keep the thyroids unblocked and to detox the body. Also has mucilage which helps heal the gut.

Aegle Marmelos – leaves are used. Inhibits lipid peroxidation, protects cells from damage, has antibacterial properties. Has been shown to fight cancer and is an adaptogen. Used to reduce chronic fatigue symptoms.

Vitamin D3 protects the cardiovascular system and nerves. Helps keep the immune system healthy. Us natural man made has been shown to have side effects. You should not take more then 4,000 IU, high doses can cause oxalates.

Ubuquinol- unoxidized form of CoQ10, use to provide the chromosomes with energy.

Quercetin- Helps heal leaky gut and nerve damage. The highest sources are elderberry juice, capers, Lovage, radish leaves, dill, Juniper berries, onions, red leaf lettuce, watercress and hawthorne leaves.

Honeysuckle- helps with cardiovascular issues and heals smooth muscle. Helps detox the body. Has mucilage which helps heal the gut.

Myricetin- helps reduce the symptoms of diabetes. Also shown to protect the nerves. Good sources are parsley, currants, yellow dock, cranberries, seeds, and blueberries. Has been shown to fight viral infections.

Kudzu- reduces histamines, and eases gastrointestinal problems. Lowers sugar levels. Helps fight cancer and is affective at aiding in suppressing alcohol cravings. Has been used to treat angina. Is an adaptogen so will help with adrenal fatigue.

Bacopa – heals brain and nerves, improves memory. Reduces ammonia levels in the body. Helps heal blood vessels throughout the body. Amazing herb.

Barberry – reduces swelling in spleen, antibacterial and anti-inflammatory. Has been shown affective against protozoa infections.

Tart Cherry capsules – helps fight heart disease , cancer, neuro-degenerative disease. Protects against muscle damage.

Maca Root helps replenish nutrients especially electrolytes. Is an adoptogen helps to balance the bodies hormones.

Ellagic Acid – inhibits binding of carcinogens to DNA. Reduces oxidative stress.

Sources are Black Berries, Cranberries, Raspberries, Strawberries, Walnuts, Grapes and Peaches. Must be coated to survive the stomache acid.

Tyrosine – if you are not methylating properly your body cannot produce it. It is used by your body to build neuro transmitters and various proteins.

Good sources are nuts, avocados, bananas, dairy products, beans and seeds.

Lotus Root – Improves digestion, reduces LDL, reduces stress hormones, strengthens the immune system and is loaded with many nutrients. Helps heal the gut.

Moringa Oleifera reduces oxidative stress and the illnesses cause by it. Helps heal leaky gut and reduce the risk of kidney stones. Also fights many infections.

Black Currant Seed Oil (Ribes Nigrum) Good source of Gamma-Linolenic Acid. Reduces arthritis symptoms, gastritis, stimulates production of anti-inflammatory hormones, helps suppress Postglandulin E2 boosting the immune system. Has been shown to be very affective at protecting the body from the flu.

Gotu Kola – has many minerals needed by the body. Has been used to treat syphilis, hepatitiis and other infections. Improves blood flow and reduces swelling in the legs.

Wild Bergamot (Monarda Didyma) – also known as horse mint. reduces fevers and nausea. Helps prevent cell damage. Has very strong antimicrobial properties. Has been shown to reduce gastric pain.

Biacalein (Thihydroxyflavone) – From the roots of Scutelleria Baicalense , Scutelleria Lateriflorg, and Oroxylum Indicum, also found in plantain herb and fleabane. Anti-inflammatory, helps heal smooth muscle also has antidepressant properties.

Glycoproteins – molecules that contain a sugar and a protein. They permit healthy cell to cell communication. They have been shown to fight bacteria, viruses, and cancer. They prevent carcinogens from attacking cells and making changes. They have been shown to strengthen the immune system.

Some have allergic reactions to them. I suspect it may be a herx reaction to a pathogen they may have that is dying off.

Foods high in Glycoproteins are mushrooms like the Reishi, Maitake, Cordyceps, Shitake and Oyster Mushrooms. Many dark colored fruits and vegetables contain them. Another source is whey protein. If you buy whey protein be careful if you have methylation problems because many companies add phenylalanine.

Choline – Needed to break down fats so our bodies can use them. Choline also helps with nerve repair. It also helps provide the body with more energy. Sources of Choline are eggs and milk products. The white parts of melons and the seeds of melons. If you get ill or indigestion when eating high choline foods it could indicate you are dealing with porphyria. I have posted on it.

Sulfur – has antimicrobial properties, has been shown to kill Candida. Sulfur is used in most processes in the body. Helps protect the lymphatic system and keep it healthy which important in the proper function of the immune system. If we do not get enough sulfur our Lymphatic System can become blocked.

Good sources of Sulfur are cruciferous vegetables, onions, garlic, kale, egg yolks from free range chickens. Cooking helps release sulfur from foods. Those with methylations issues and high sulfite levels need to address that before eating high sulfur foods.

Butchers Broom lowers ammonia levels, helps with hemorrhoids, reduces oxidative stress, has been shown to reduce the symptoms of POTS and Cardidtis. Has strong anti-inflammatory properties. Those with type 1 diabetes should not use this they could develop ketoacidosis.

Savory – has Oleanolic Acid and antioxidants. Aids in the repair of DNA. Is also an antispasmodic. Helps unblock Nrf2 pathway.

Mullein (verbascum thapsus) Has antibacterial and expectorant properties. Has also been shown to fight mycobacteria, Is a natural anti-inflamatory. Helps ease menstrual and stomach cramps. Helps normalize estrogen.

Zinc is necessary for the synthesis of proteins. Zinc is important for the proper function of the immune system, keeping eyes healthy, for healthy skin, protecting memory, repair and function of DNA and strengthening of bones.

Good sources of zinc are ginger root, fish, oats, whole wheat, !!Too much zinc inhibits the bodies ability to absorb copper!!

Chirata – reduces fever, fights things like malaria, Candida and parasites, also reduces nausea. Used in tincture form.

Cinnamon relieves gas, nausea, kills bacteria,H pylori, and Candida has been listed as a very affective pain killer.

Bee Pollen has many of the nutrients the body needs, it is a super food. High in protein.

Grape Seed Extract – thins the blood, reduces bradykinin which causes inflammation and damages nerves and smooth muscle. Also has many healing properties be careful it thins the blood. Helps with carditis. High in reveratrol.

Narigenin – found in grape fruit. Reduces histamines and inflammation. Has been shown to repair DNA. Reduces Hepatitis C. Has antidepressant affects. Cannot be taken with most medications. This inhibits cytochrome P450 enzymes needed to detox medication from the body. It should not be taken often but has been found to be very effective against gut dysbiosis. I only took it twice a week and it really reduced my bloating.

Fisetin- reduces inflammatory cytokines. Can up-regulate gluthione production. Good sources are most berries, fruits and vegetables. It also has nueroprotective properties.

Catuaba Bark – Opens blood vessels so blood can flow more easily, has anti-inflammatory properties, protects the skin from damage, has been shown to reduce symptoms of Parkinsons disease, has antidepressant affects, has been shown to be affective against HIV and other viruses.

Baai (Puerariathunergiana) – antiviral,antispasmotic, lowers blood pressure, shown to help with alcoholism. Scavenges free readicals and reduces alleric reactions. Makes HIV drugs more affective.

Caesalpinia Sappan – antibacterial, anti-inflammatory, reduces aging, protects liver and reduces acne. Helps prevent Peroxide formation, and lowers blood pressure.

Fulvic Acid – Helps the bodies cells to release heavy metals. Helps protect the brain from cognitive impairment. Promotes electro chemical balance throughout the body. Makes minerals more biochemically available. Has been shown to revitalize dying cells. !!Research has not been done on large dose intake of Fulvic Acid so do not overuse or take in large quantities.!!

Lower Cortisone

Lowering stress hormones can reduce histamines.

Eucommia Bark – encourages collagen development, lowers blood pressure. It does not lower blood pressure in those with low blood pressure. Strengthens the immune system and lowers stress hormones.

Purines and Pyrimidines – essential for building molecules that carry our genetic code and produce the proteins necessary for a healthy body.

Foods that support their production are foods high in glutamine, glycine and aspartate like greens , cabbage, oats, eggs, lentils, peanuts, almonds, legumes, all increases our production. !!If you have gout or inflammation high purine foods can make it worse, you may want to decrease your intake of animal flesh, asparagus, beans, legumes, mushrooms, scallops, sardines,coffee, tea and cocoa.

Lionsmane – high in protein, has neuro-protective properties. Lionsmane has been shown to improve memory and reduce plaque in the brain, it has also been shown to reduce depression.

Uridine – -Helps DNA repair. Foods that increase uridine are beer, wine, tomatoes, brewers yeast, broccoli, fish, nuts, molasses and Non GMO beets.

Suma Root – (Pfaffia Paniculata) an adaptogen, reduces fatigue, normalizes estrogen and testosterone. High in electrolytes and other nutrients.

Useful Info On Food And Herbs.

These are a list of things I have found in my research to try to heal from Lyme. This is not medical advice if you are not well see a doctor. If you take any supplements or herbs let your doctor know. Only take one new item at a time so if you have a reaction you will be able to figure out what caused the reaction. A good site for drug interactions is http://www.webmd.com .

Try your best to stay away from GMOs and vaccinations,processed foods with their saturated fats. By now you should know the harm they do to your body. I put this list together to give others an idea on some things they could research.

CoQ10 – Ubiquinol which is the unoxidized form of CoQ10 is the most bio-available form. It protects the mitochondria, cardiovascular system. It helps with the bodies energy production at the cellular level. It helps regulate blood sugar levels and improves the health of the immune system. It is fat soluble so must be taken with a healthy fat. Recommended Daily (RDA) allowance is 90 to 100 micrograms (mcg)

Lipoic Acid – First line of defence for disease. Regenerates antioxidants. Bio-active form is R-Alpha-Lipoic-Acid.

L-Carnitine – required to transport fatty acids to mitochondria, protects and heals nerves. Protects and heals nerves. Found in meat and milk products, also found in asparagus. Also helps remove toxic compounds generated in cells.

L-Glutamine – heals soft tissue.

Some sources are chicory root, Jerusalem artichoke, dandelion root, burdock, salsify, onions, and garlic.

Probiotic With Active Acidophilus and Bifidus – helps restore good gut bacteria. The good gut bacteria helps protect from cancer and infection, it also helps break our food down. Do not over do them or they will do the opposite.

Fermented Foods – Helps restore the bodies good bacteria, protects from infections and helps break our food down.They are high in histamines so if you are having high cytokine levels avoid fermented foods. Those with allergies or mast cell activation syndrome should avoid fermented foods.

Vitamin E (Tocopherols, Tocotrienols) With vitamin E always make sure it does not start with the letters DL, if it does then it is man made and our bodies does not use it very well.

Vitamin E Helps with energy production in the cells, protects the cardiovascular system, it is also and antioxidant. Sources of Vitamin E are nuts, seeds, greens, dark colored fruits and vegetables most organic cooking oils.

Vitamin C most bio-available form is Liposomal Vitamin C. The body needs Vitamin C to detox and repair the body. It has also been shown to fight many pathogens. Helps the body absorb Iron more readily. !! If you take too much Vitamin C you can flush important minerals from the body. It can also destroy red blood cells , also too much vitamin C can raise oxalate levels.!!

Virginia Pepperweed – contains isothioyanates which have antibacterial, antifungal, anticarcinogenic and anti-parasitic properties.

Allspice – anethetic, antioxidant, relaxant, stimulates blood circulation, stimulates cell growth and repair. !! In high doses causes many side affects. !!

Cat’s Claw – helps the body detox, also works as an adaptogen on the immune system.

Avena (Oat Straw) Helps balance our electrolytes. Has many nutrients needed for healing and proper functioning of the lymphatic system, helps improve cardiovascular health. Also has relaxant qualities and kills pain. Most say it doesn’t affect them but it knocks me out. Kills pain.

Boron helps remove toxins like chlorine.

Molybdenum – reduces oxidative stress, helps remove toxins produced by the body. It is needed to metabolize fats and carbohydrates. Also helps remove many other toxins from the body. Most do not need to supplement this. Good sources are greens, vegetables, seeds, melons, unfiltered water. Make sure you do not get too much. I sign of not having enough molybdenum is high ammonia levels.

Oleanolic Acid – Found in Olive Oil and Savory. It has been shown to unblock the Nrf2 pathways. If the Nrf2 pathways are blocked DNA and RNA cannot repair.

Vitamin D3 – helps regulate gene expressions, it also helps regulate epigenetic DNA methylation processes. Vitamin D3 has been shown to protect the cardiovascular system, it also aids in the absorption of calcium.

Zinc – Helps with DNA repair and synthesis of Protein. It is important for the proper function of the immune system. It helps keep the eyes, skin and memory healthy. It helps strengthen our bones. !! Too much Zinc can inhibit the bodies ability to absorb copper.!!

Good sources are shellfish, Oats, Whole Wheat, Ginger Root

Iodine – helps detox the body. It controls the function of the thyroid glands which affect metabolic processes in the whole body. It helps optimize the use of our bodies calories. The RDA is 75 to 150 mcg. Good sources of Iodine are seafood and seaweed. Unfortunately most sources of those are contaminated. Most table salt is enriched with iodine. Too much iodine can cause problems with the thyroids.

Magnesium – important in all the bodies functions, supports the immune system, prevents inflammation, reduces the risk of heart attacks.

Intake of Magnesium and Calcium should be balanced as closely as possible. The recommended RDA is 400 mg. Sources of Magnesium are leafy greens, bananas, most fruits and vegetables, oatmeal and chocolate. Most foods contain adequate amounts of calcium.

Calcium – Important for healthy bones and cardiovascular system. It is important for the regulation of the sodium pumps that control our muscles. Good sources of Calcium are found in greens, veggies, oranges and shellfish. Most foods contain adequate amounts of calcium and it is rare to need to supplement calcium. Most bone loss is from silica or magnesium deficiency.

Cholesterol – the body can produce Cholesterol. It is necessary for all body functions especially the brain. It helps the body break down and absorb fats. It is also important in the manufacture of hormones and balancing of the hormones. It is an antioxidant that protects our bodies from cancer. It is critical in the repair of damaged cells. A deficiency in Cholesterol can cause Leaky Gut Syndrome.

Sources of good Cholesterol are meat from grass fed animals, eggs, avocados, legumes and beans.

LDL is the oxidized form of Cholesterol which is bad for our bodies. It is found in grain feed meat, and processed foods.

Protease Ezymes – Supports good gut bacteria. Have been shown to aid with digesting cell walls of pathogens. Helps with methylation and lower homocystein levels which will lower ammonia levels. Some protease Enzymes are bromelain from pineapple, betaine from beets, and Papaya. Be careful of your source because there are GMO Papaya and Beets now. Nattokinase is a protease enzyme that has been shown to help with fatty liver disease. Serrapeptase reduces inflammation, reduces scar tissue in the body and improves blood flow.

Hops Tea inhibits cancer, known to remove many toxins from the body. Protects the renal system. Promotes proper functioning of the thyroid and has been shown to protect the cardiovascular system. Has been shown to fight many infections, even reduces aids symptoms. Has a cannabinoid that reduces pain. !! Overuse can cause seizures!!

Vitamin K2 – Prevents Osteoporosis, protects us from cardiovascular disease. Reduces cancer and Alzheimer conditions. It controls were calcium goes and does not go. Helps with the function of the muscles.

Good sources of Vitamin K2 are milk from grass fed cows for some reason grain fed cows do not produce very much K2 !! Do not confuse with K3 which is man made and toxic to the body.!!

Biotin – regulates gene expressions. Reduces CO2 levels in the body.

Some food sources are egg yolk, whole grains and cheese.

Lycopene – Helps protect the heart and reverse damage to the heart. Sources of Lycopene are cooked Tomatoes, grapefruit, pretty much all colored fruits and vegetables. Cooked tomatoes are the best source though.

Hyaluronic Acid – helps heal connective tissue throughout the body and skin.

Tumeric – contains Curcumin which has been shown to reduce MS sysmptoms and fight cancer. Has antimicrobial properties. It has also been shown to protect the renal system. Fresh ground pepper makes it more bio-available to the body. Should not be taken too often or for too long. Curcumin chelates iron so if taken for too long you can become anemic. It good for those suffering from iron overload.

Ginger – has many micronutrients and antioxidants. Has been shown to reduce inflammation. Improves blood flow. It improves the absorption of nutrients into the body. It stimulates the pancreas and is a natural pain killer. Has been shown to induce cell death in cancer cells. Promotes bone health and reduce menstrual cramps. Helps fight nausea and fight infections. Has been shown to heal the gut. I reacted to this the first few times I used it but after that I was fine.

Horsetail Herb – contains silica which the bones need for healing and to remain healthy, silicon is also needed by the body for detxoing. !!Some studies claim to much silica can cause kidney stones and others claim it does not. I would not over use. Do not take often, horsetail does contain a chemical that can be toxic if taken in excess!! Horsetail herb also has an alkaloid that can build up in the body so I would not use this often.

Panax Ginseng – Impedes cancer growth and promotes cancer cell destruction. Improves circulation which improves healing.

Rehman – helps with detoxing, has been shown to reduce fibromyalgia symptoms. Also helps regulate the immune system. !! Can cause bloating!!

Honeysuckle – many antioxidants, has been shown to kill bacterial infections. Heals smooth muscle and cardiovascular system. This one helped with my myocarditis.

Policasamol – prevents blood clots helps regulate blood pressure, also balances cholesterol. It is extracted from sugar cane. It reduces inflammation.

Butchers Broom – Has been shown to reverse osteoporosis. Lowers ammonia levels in the body.

Evening Primrose (Oenothera Biennis) Has Gamma Linolenic Acid (GLA) which has been shown to heal many areas of the body even smooth muscle. Very good for skin health.

Citruline – helps remove ammonia from the liver. Helps strengthen the immune system. Also helps to maintain nitrogen balance in the body. Studies have shown it reduces atherosclerosis. Helps reduce fatigue and increase energy in the body.

Sources of Citruline are melons, sguash, legumes, and protein rich foods.

Clary Sage – benefits eyes, nervous system, also aids in digestion. Helps regulate blood pressure and normalize it. Has antispasmodic properties.

Eupatorium Perfoliatum – also known as Boneset and Feverwort. It has been shown to be affective against the common cold and the flu. Aslo affective at treating cytokine dysregulation. Has been shown to be very affective against the plasmodian parasite.

White Peony Root – reduces diabetes induced oxidative stress. Decreases urinary albumin. Protects the liver from oxidative stress. RDA is 100 to 200 mg per kilogram of weight.

Bupleurum – promotes new vein growth and strengthens capillaries. !!Stimulates the immune system and causes flatulence!!

Coltsfoot – anti-inflamatory and eases coughs.

Fireweed – Helps normalize gut flora, supports the good gut bacteria. Reduces inflammation and symptoms of irritable bowel syndrome.

Silver Weed (Potentilla Anserina) The leaves have antiviral properties, and contains more flavonoids then green tea. Has been shown to be hepatoprotective.

Manganese – Necessary for proper brain function and pituitary function. Manganese is also necessary for healthy bones and works as a coenzyme to assist in metabolic activity.

Good sources of manganese are berries, pineapple, garlic, greens, Non GMO beets, fruits, vegetables, molasses, and coconuts.

L-Dopa (Levodopa) The body uses it to make Dopamine. Our bodies will produce it but many who are ill do not produce enough.

Good sources of L-Dopa are Fava Beans, Mucuna Pruriens, and Broad Beans. Those who are G6PD deficient should not eat Fava Beans.

Good carbohydrates – Good carbohydrates stabilize things throughout our bodies. Good sources are sweet potatoes, oats, brown rice, legumes, beans, quinoa, fruits and vegetables.

Jaiogulan – (Gynostemma pentaphyllum) Helps the body achieve homeostasis by lowering oxidative stress. Has many of the same phytochemicals as gensing. Reduces oxidative stress and inflammation.

Uridine – -Helps DNA repair. Foods that increase uridine are beer, wine, tomatoes, brewers yeast, broccoli, fish, nuts, molasses and Non GMO beets. I would not supplement , high levels of uridine can stimulate cancer growth. That being said uridine stimulates growth of brain and nerve cells. It reduces pain and inflammation. It increases cognitive abilities. It works best if consumed with fish oil.

Wasabi – reduces risk of cancer and heart disease, has anti-inflammatory properties. Helps fight bacterial infections. It also reduces allergy symptoms and detoxes the body. Wasabi is packed full of nutrients.

Oregano Oil – contains Carvacrol which protects the liver, has been shown to inhibit cancer growth. Works as a good nontoxic disinfectant. Has been shown to be as affective as chlorine. It kills Candida and helps protect the cardiovascular system from LDL and reduces inflammation.

Lionsmane – high in protein, has neuro-protective properties. Lionsmane has been shown to improve memory and reduce plaque in the brain, it has also been shown to reduce depression.

Luffa Gourd – Strengthens the immune system, reduces fevers, detoxifies the body and aids the body with hydration. Has been shown to reduce heart palpitations and hair loss.

Nobiletin – prevents metabolic syndrome. Protects from obesity, prevents artheriosclerosis. This is extracted from the peels of citrus fruits. Stimulates cellular macrophagy. Should not be used more then a couple times a week.

Fulvic Acid – Helps the bodies cells to release heavy metals. Helps protect the brain from cognitive imparement. Promotes electro chemical balance throughout the body. Makes minerals more biochemically available. Has been shown to revitalize dying cells. !!Research has not been done on large dose intake of Fulvic Acid so do not overuse or take in large quantities.!!

Aerva Lanata – has diuretic, anti-inflammatory, antispasmodic, antiparasitic, antimicrobial, hepa-protective and anti-asthmotic properties.

Agrimony – reduces inflammation, improves digestion, improves bladder control, detoxes the body and improves hair and nail health.!!Taking too much can cause constipation!!

Cissus Quadrangularis – reduces inflammation, improves bone health, improves respiratory health, eases pain and stimulates the production of osteoblast which are needed for bone growth and healing.

Camu Camu – high in vitaminb C, helps block build up of plaque in the brain, reduces symptoms of depression, improves muscle tone.

Black Radish – used to treat nutritional deficiencies. Helps remove toxins from the blood. Has antimicrobial and antibacterial properties.

Eucommia Bark – encourages collagen development, lowers blood pressure. It does not lower blood pressure in those with low blood pressure. Strengthens the immune system and lowers stress hormones.

Moringa Oleifera – has antibacterial properties. Has been shown to stabilize blood pressure. Helps reverse some liver damage. Contains Quercetin. The seeds have been shown to improve asthma symptoms. Also reduces histamine levels.

Graviola (Annona Muricata) – soursop has been shown to kill cancer cells, suppresses the herpes simplex virus. Has been shown to reduce swelling and pain. !!Taking to long or too much can damage nerves. !!

Celery Seed Extract – reduces risk of stroke. Improves blood flow and has been shown to protect the brain. Also lowers histamines and inflammation. Has been shown to help heal leaky gut.

Periwinkle – helps bleeding gums, reduces Alzheimer symptoms, reduces headaches and vertigo.

Black Currant Seed Oil (Ribes Nigrum) Good source of Gamma-Linolenic Acid. Reduces arthritis symptoms, gastritis, stimulates production of anti-inflammatory hormones, helps suppress Postglandulin E2 boosting the immune system. Has been shown to be very affective at protecting the body from the flu.

Olive Leaf Extract – has antibacterial , and anti-inflammatory properties. Lowers blood pressure and LDL levels. Olive Leaf Extract has been shown to protect the cardiovascular system. It is a broad spectrum antiviral and antimicrobial agent. !!Be careful it can drop your blood sugar levels.!!

Aegle Marmelos – leaves are used. Inhibits lipid peroxidation, protects cells from damage, has antibacterial properties. Has been shown to fight cancer and is an adaptogen. Used to reduce chronic fatigue symptoms.

Hydrangea Macophylla Root – helps with autoimmune disorders while allowing the immune system to function normally.

Bethroot (Trillium Erectum) Stimulates menstration, is an expectorant, can stimulate labor during pregnancy.

Acanthus Ilicifolius – increases production of osteoblast which are necessary for bone growth and health. Has been shown to help gastric ulcers heal. Has strong antibacterial and antifungal properties.

Boabab – high in vitamin C, much more then oranges. Has very good hepaprotective properties. Loaded with minerals. Can be purchased as a powder.

Bakula (Mimusops Elengi) diuretic, gastroprotective, antibacterial, antifungal, anticancinogenic, scavenges free radicals, has been shown to hinder HIV.

Cynanchum Stauntonii – improves endothelial function, inhibits the formation of atherosclerosis.

Ajuga Decumbens improves liver and kidney function, helps correct hypoglycemia.

Caesalpinia Sappan – antibacterial, anti-inflammatory, reduces aging, protects liver and reduces acne. Helps prevent Peroxide formation, and lowers blood pressure.

Sea Bean (Salicornia) – High in protein,calcium and iodine. Has many micronutrients.

Bitter Ash (Picrasma Excelsa) Reduces colitis symptoms, and has antiviral and antibacterial properties.

Cancer Bush (Sutherlandia Frutescens) Fights cancer has been shown to reduce HIV symptoms.

Maytemus Heterophylla – has antibacterial and antimicrobial properties. Reduces inflammation.

Baai (Puerariathunergiana) – antiviral,antispasmotic, lowers blood pressure, shown to help with alcoholism. Scavenges free radicals and reduces allergic reactions. Makes HIV drugs more affective.

Catuaba Bark – Opens blood vessels so blood can flow more easily, has anti-inflammatory properties, protects the skin from damage, has been shown to reduce symptoms of Parkinsons disease, has antidepressant affects, has been shown to be affective against HIV and other viruses.

Spatholobus Suberectus – strong antiviral, improves the health of blood, reduces arthritis symptoms, anti-inflammatory, affective against cancer, thins blood and has sedative affects.

Quaking Aspen (Populus Tremuliodes) High in salicylates which is converted to aspirin in the body. Reduces pain, fever, inflammation, thins blood, detoxes the body and has antibacterial properties.

Club Moss, Devils Claw (Lycopodium Clavatum) anti-inflammatory improves memory.

Bee Pollen – High in protein, contains almost all nutrients required by humans. There is a substance in be pollen that inhibits the development of bacteria. It strengthens our blood. Normalizes cholesterol and has been shown to help fight cancer.

Geranium Pelargonium – this is the only Geranium species that can be consumed. It is an adaptogen, reduces stress hormones, reduces pain and inflammation, reduces headaches, helps the body to detox by stimulating the kidneys. Has antifungal and antibacterial properties. Has been affective at reducing cold and flu symptoms.

Wild Bergamot, Horse Mint ( Monarda Didyma) Settle stomach, reduces fevers, helps prevents cell damage, helps with urinary tract infections.

Indian Paintbrush (Castilleja) Only the flowers are eaten, the rest of the plant is too high in selenium. Has similar health benefits as garlic. It enhances the immune system. Helps the body to detox, the rest of the plant is too high in selenium to consume.

Apple Leaf helps heal the gut.

https://link.springer.com/article/10.1007%2Fs13765-015-0021-2

Lemon Verbana (Glycyrrhiza Glabra) reduces muscle damage, improves joint mobility and reduces joint pain. Improves the health of the immune system.

Red Rooibos Tea (Aspalathus Lenearis) Has antiviral, anti-inflammatory,antimutagenic qualities. Scavenges free radicals. It is a relaxant with many minerals needed for bone health. Protect the cardiovascular and pulmonary system. Helps with colic in babies. Also helps detox the body and is very good for fighting lung infections.

Star Grass (Hyposis Hemerocallidea) Has antibacterial and anti-inflammatory properties. Has been shown to be affective against breast cancer. Has been shown affective against HIV.

Lithospermum Erthrohizon – inhibits HIV virus, prevents ovalation in women with no side affects. Also hinders hardening of the arteries.

Sweetflag (Acorus Calamus) reduce epilepsy symptoms. Kills Candida and fungal infections. Hinders inflammatory cytokines. Has been shown to be affective against cancer.

Bixa Orellena (Annatto) – Used to treat gonorrhea and many other bacterial infections. Helps prevent DNA damage. Reduces oxidative stress and protects the renal system.

Bearberry (Uva Ursi) helps with urinary tract infections. I have seen websites saying it can damage the liver but when I looked at toxicity studies it showed it to be safe. It reduces oxidative stress and kills infections in the renal system.

Pau D Areo Tea (Tabebuia Allanedae) – Fights cancer, kills bacterial infections, and is affective at killing parasites. !! Do not concentrate it contains Quinone which can damage the liver in high doses.

Use no more then two 8 ounce cups a day.!!

Mustard – anti-inflammatory. Has been shown to help with chest congestion. Very high in antioxidants and lowers LDL.

Sage reduces muscular pain, improves memory and reduces oxidative stress.

Sarsparilla (Smilax) Has been used to treat gonorrhea, leprosy, bacterial and viral infections. Has anti-inflammatory affects. Has been shown to limit the amount of toxins that can enter the blood stream. It protects the renal system and reduces oxidative stress.

Vitex (Chasteberry) Supports the endocrine system. Works as and adaptogen for women.

Thyme (Thymus Vulgaris) Shown to increase white blood cell production. Has a relaxing affect on the muscles. Has been shown to reduce oral infections. Has many minerals like copper, iron, and manganese. It boost the feeling of well being. !! If taken in large doses has many side affects!! Also will work as an insect repellent.

Andrographis – fights many pathogens. It has many antimicrobial properties. Boost the bodies immune system. Can prevent and dissolve blood clots. Relaxes smooth muscle which lowers blood pressure.

!!Has many side affects!!

Galangal Root (Alpinia Officicaram) Relieves nausea, has antifungal and anti tumor properties.

Golden Rod (Solidago) a diuretic, has been shown to fight bacterial and urinary tract infections. Eases muscle spasms and reduces high blood pressure. Helps with reducing ammonia and other toxins in the body.

Juniper Berries – has been shown to inhibit bacteria growth. !!Long term use can cause liver damage!!

Schisandra – has antioxidants and anti-inflammatory properties. It is also an adaptogen. It has been shown to reduce stress hormones and improve concentration. Has been used to treat hepatitus. !!only use a few berries at a time and not for extended periods of time.!!

Tribulus Extract (Puncture Vine) Boost endurance and helps increase muscle mass. Similar chemically to anabolic steriods. Boost testosterone production. Strengthens the immune system. Reduces oxalates in the body.

Mullein (Verbascum Thapsus) has antibacterial and expectorant properties. Has also been shown to fight mycobacteria. Is a natural anti-inflammatory. Helps ease menstrual and stomach cramps.

Siberian Ginseng – each type of ginseng has it’s own properties. You must research which ones are best for you. Siberian Ginseng is an adaptogen. It has been shown to lower stress hormones. Studies suggest that it may strengthen the immune system. It has been shown to reduce the number of outbreaks of herpes. It has also been shown to improve mental health. !!Do not give to a child, if you have high blood pressure do not take.!!

Ladies Thumb (Polygonum Persicarla) Has antiherpetic properties. High in saponins which aren’t toxic but if consumed in high quantitites they can inhibit nutrient absorption.

Smartweed (Polygonum Pennsylvnicum) Has the same properties as Ladies Thumb, looks similar also.

Myricetin is a heliacase inhibitor. Helps fight viral infections. Also has anti-inflammatory properties. Has many antioxidants. Most dark colored produce contains Myricetin.

Croton Lechleri the sap is latex and is used as a liquid bandage. It has been shown to heal gastric ulcers.

Borage – Contains choline which is needed for methylation. Shown to reduce stress hormones. Do not use in hight doses or it will do the opposite. It contains an alkaloid that can damage the liver and kidneys if it builds up in the body.

Noni Extract has antioxidants and immune boosting properties. Helps lower blood sugar and is high in pottassium.

Hovenia Dulcis – protects the renal system, reduces oxidative stress. Helps to protect the brain. RDA 1400 to 2500 mg.

Polygala Tenifolia – reduces stress hormones improves memory.

Bacopa – heals brain and nerves, improves memory.

Bromelain extracted from pineapple. Reduces pain and inflammation. Has anti parasitic and antimicrobial properties. Kills Candida. Promotes muscle and connective tissue repair.

Aloe Vera contains Latex which helps heal leaky gut. Has been shown to kill Candida and help regulate the immune system. I get the liquid capsules, I do not like the textures of the juice. The dried capsules didn’t seem to work. Has been shown to reduce histamine levels.

Chamomile – reduce muscle spasms, reduces pain and menstrual cramps. Also reduces histamines.

Wild Daisies -related to Chamomille does the same things only taste better.

– reduce muscle spasms, reduces pain and menstrual cramps. Also reduces histamines. Also reduces pain and has mild sedative effects.

Tongkat (Eurycoma Longifiolia) enhances bodies adaptive response to exercise, also increases testosterone levels.

Muira Puma – aprodisiac in men and women. Helps the body produce healing hormones.

Maca Root gives the body energy. High in minerals and vitamins. Stimulates and nourishes the hypothalamus and pituitary glands which control all other glands. Helps the body achieve homeostasis.

Dandelion – high in vitamin K, has been shown to protect the renal system and to aid in the removal of toxins from the body. Has many antioxidants and micronutrients that help fight cancer. Reduces histamines.

Ellagic Acid – inhibits binding of carcinogens to DNA. Reduces oxidative stress.

Sources are Black Berries, Cranberries, Raspberries, Strawberries, Walnuts, Grapes and Peaches.

Potassium -helps keep the heart healthy, aids in blood flow, helps keep muscles healthy, helps protect nerves also helps the liver filter blood. Helps balance our water levels. !! Too much can cause major heart issues.!!

Sources are Tomatoes, Avocados, Bananas, Oranges, Strawberries, Grapes, Prunes, Beans and Legumes.

Astralagus – protects the chromosomes from degredation. Boost immune system and reduces oxidative stress.

Hawthorne – Improves circulation protects blood vessels. Helps with osteoporosis. Reduces oxidative stress.

Vitamin A -allows for proper gene activation within the lymph glands which helps the body develop proper immunity.

Sources are orange colored fruits and vegetables, Kale and fish.

Red Clover Tea – improves bone health, increases estrogen production.

American Skullcap Tea – not to be confused with chinese which has different health benefits. American Skullcap promotes relaxation, reduces seizures, inhibits food allergies.

Prickley Lettuce – contains opiad like Lacturearium, but is not addictive.

Vitex also know as Chasteberry. Supports the endocrine system. Aslo works as an adaptogen for women.

Tribulais Extract (puncture vine) Boost endurance and helps increase muscle mass. Similar chemically to anabolic steroids. Boost testosterone production and strengthens the immune system.

Mullein (verbascum thapsus) Has antibacterial and expectorant properties. Has also been shown to fight mycobacteria, Is a natural anti-inflamatory. Helps ease menstrual and stomach cramps.

Chinese Knotweed (Fo-Ti) Strengthens bone and prevents hair loss. Supports healthy adrenal function.High in oxalates should not be taken if you are not sulfating right or have issues with vitamin C should not take this.

Zinc is necessary for the synthesis of proteins. Zinc is important for the proper function of the immune system, keeping eyes healthy, for healthy skin, protecting memory, reapair and function of DNA and strengthening of bones.

Good sources of zinc are ginger root, fish, oats, whole wheat, !!Too much zinc inhibits the bodies ability to absorb copper!!

Ginger Root improves blood flow, reduces nausea, improves absorption of nutrients into the body, ginger root also stimulates the pancreas, and is a natural pain killer. Ginger Root has been shown to induce cell death in cancer cells. Ginger Root promotes bone health, has been shown to fight infections and reduce menstrual cramps. Reduces histamines.

Horse Gram (Dilichos Biflorus) Help dissolve kidney stones, also kills many pathogens. The seeds are used to make tincture.

Cambogia (Cortexmoutan Radycus) Helps asthma. shown to upregulate Il-4. Cambogia also thins the blood.

Figwort – Good for the lymph glands and improves blood circulation improves the function of the cardiovascular system.!!Do not use if you are a diabetic.

Coptis (Berberine) The root is used. Coptis aids digestion and the pancreas, kills many pathogens and parasites. Usually comes in tincture or powder form.

Vervian – antispasmotic, helps recover nerve function. Relieves menstrual symptoms. Used in tincture or tea form.

Phellodendrum Amurense – Alleviates arthritis pain, improves bone health, helps preserve nerve function, increases glutathione levels, is also antimicrobial.

Woad – (Isatis Tinctoria) Antibacterial, antiviral and has been shown to inhibit cancer. Root used to make tincture. !!Do not use if you are allergic to aspirin.

Chirata – reduces fever, fights things like malaria, Candida and parasites, also reduces nausea. Used in tincture form.

Forsynthia Suspensa – fights lung infections, tonsillitis, and gonorrhea. Forsynthia also thins the blood.

Verbena – antispasmodic and and reduces fever. Flowers used for tea.

Yarrow (Achillea Millefolium) Has antimicrobial properties, lowers blood pressures. Has been used to clot blood in wounds. The essential oil kills mosquitoes.

Eclipta (Eclipta Prostracta) Reduces oxidative stress, protects the liver, has been shown to reduce pain better then aspirin and stimulates hair growth.

Yellow Dock also known as Curly Dock. Has laxative properties, high in iron, also has antibacterial properties. Has Glycosides that aid with detoxing and mineral absorbtion. !! The leaves are High in oxalates which can cause gout and kidney stones do not eat the leaves without cooking.!!

Red Clover – flowers are used to make tea. Has estrogen like affects. Helps with symptoms of menopause. Can reduce estrogen levels if they are high. Works as an expectorant and antispasmodic.

Varuma – Bark, root and leaves are used. Good at breaking up kidney stones, also hinders their formation. Has anti-inflammatory affects. The root is a laxative. Varuma also helps with flatulence and gas pains. !!May cause blistering if used on the skin!!

Tansy (Tanacetum Vulgare) – Leaves and flowers are used. Gets rid of parasites. Also a good insect repellent.

Passion Flower – Aids with opiate withdrawal, has sedative affects. Has been used to treat ADHD. Has been shown to ease symptoms of drug withdrawal. !!Do not drive or operate machinery when using.!! Long term use can damage the liver.

Bitter Mellon also know as Bitter Gourd – Has many vitamins and minerals. Helps with diabetes. Has antiviral and antibacterial properties. !!Overuse can cause digestive problems and headaches.!!

Nutmeg – Strong antibacterial properties. Has been shown to reduce the occurrence of seizures. Good for diarrhea. !!Over use of this can do the opposite, it can cause seizures and could even cause death.!!

Serrapeptase -derived from a type of silk worm bacteria.It aids the moth in digesting the cocoon so it can exit the cocoon. Serrapeptase has been shown to remove scar tissue from fibrosis, break up blood clots, reduce scar tissue in the lungs, break up cyst and even plaque in the blood vessels. It is PH sensitive so it must be coated. Do not take high doses, it can negative impact the body in high doses.

Papain – aids digestion of proteins. Has been own to reduce symptoms of many herpes viruses !!Do not take if you are allergice to papaya, also be careful I think there is GMO Papaya.!!

Spirulina Provides protein, many vitamins and is a good source of chlorophyll. Very high in Gamma-Linolenic Acid. Has the same minerals as milk. Improves blood vessel elasticity, which improves neuro-protective affects. !!Make sure the source is from uncontaminated waters.!!

Opium Lettuce helps with spastic colon.

http://europepmc.org/articles/PMC3638630

Those who have issues with their digestion that causes the food to sit and ferment instead of digesting properly my not want to use apple cider vinegar. It delays digestion even more.

https://www.ncbi.nlm.nih.gov/pubmed/18093343

Yarrow helps heal the gut.

https://www.sciencedirect.com/science/article/pii/S0378874106001565?via%3Dihub

Also read my post on Beta Glucan because it helps heal the gut.