Why correcting inhibited bile or constipation is not always so simple.

I am asked pretty often how to correct inhibited bile flow. This is not and easy question to answer and there are many things that can cause it. I will show you how complex of a question that is. There are a huge number of things that can effect bile production. It is probably one of the most difficult things to correct because there is a lot of questions that need answered to know what is causing to occur and it is different in each individual. If bile is inhibited then gall bladder issues will pretty much be a given. A person with issues in bile flow will have trouble digesting food it will sit like a brick in their stomach and ferment. If they have motility issues the bile they do produce will enter the stomach so they would still appear to be deficient in bile. The way to break the cycle is to correct what is causing it but it is not simple figuring out why. So here is the list of things that can cause inhibited bile flow or inhibited motility (constipation). This is by no means a complete list. This is also why there are many question that need answered when constipation is chronic.

High estrogen levels.

High copper levels

Low serotonin levels.

High noadrenaline levels or high adrenal hormone levels also connected to copper.

Low substance P levels.

Inflammation

candida overgrowth or gut dysbiosis

low cholesterol or issues with cholesterol metabolism

inhibited vitamin D receptor or low vitamin D levels.

Inhibited retinoid x receptor

lactase deficiency which cause lactose intolerance and is a sigh of a deficiency in saccharmyces boulardii.

Low amylase

Poor mucous membrane health

lipase deficiency

excess pancreatic polypeptide

pancreatic elastase deficiency

hypothalamus injury or issues.

High insulin levels

Nutrient deficiency or issues with protein metabolism especially taurine

electrolyte deficiencies

Low cysteine levels

low vasoactive peptide levels

high glucagon levels

high secretin levels

high somatastatin levels

Gastin hormone from low histamines

low bombesin levels

high cholecystolinin levels

infection

leaky gut

issues with sulfation or high sulfite levels

bile duct obstruction

T cell imbalance

high oxalate levels

High Lysolecithin found in processed foods.

High COX-2 levels

Not getting enough medium chain fatty acids.

High sulfur digesting or methane producing bacteria levels , dysbiosis

Decreased COMT activity

High folic acid levels which is not the same as folate

Low betaine homocysteine S-mthyltransferase levels which leads to hypothyroidism

choline deficiency or issues with choline metabolism

Deficiency in Akkermansia Muciniphila

Issues with lipid metabolism

Issues with the Kreb’s cycle also known as the citric acid cycle.

Low HNF4a levels

High B-hydroxybutyrate levels caused by low oxaloacetate levels.

Hydrolase synthase deficiency

alkaline phosphatase deficiency which inhibits bile and decreases good gut bacteria levels in the gut increasing the bacteria that inhibit bile.

Inhibited FXR receptor

decreased motilin

Inhibited ABCB4

Inhibited CYP7a1 enzymes

pyruvate carboxylase deficiency

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Porphyria is the illness, pyrroluria and kryptopyrolluria are symptoms of the illness.

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This is not medical advice and should not be taken as such. I am posting this for informational and educational purposes.

Porphyria

If you have problems with consuming fats, like gall bladder pain, indigestion or feeling ill after eating them you most likely have Porphyria. You may be told you have Pyrolluria but it is a symptom of Porphyria.

Many know this as Pyrolluria or Kryptopyrolluria. You do not see updated research on those disorders because they discovered the high pyrroles was caused by a deficiency in various enzymes needed to break down uric acid. It causes high porphyrin levels. If you have Pyrroluria then look at the link and you will see the symptoms are the same. Pyrolluria is a symptom but not the problem. There are many things that can cause Porphyria , infection, drugs, chemicals, excess iron, stress, and to much sun. Fasting too much can also cause it. This can cause high ammonia levels because phenylalanine cannot be recycled.

https://www.medicinenet.com/porphyria/article.htm#what_causes_porphyria

https://www.mayoclinic.org/diseases-conditions/porphyria/symptoms-causes/syc-20356066

Infection

http://msphere.asm.org/content/1/1/e00023-15

http://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-39-4-262;jsessionid=Nxep_9-RQ5BILTpRdyrNY-OW.x-sgm-live-02

http://europepmc.org/abstract/med/2564227

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647859/

Clinical management.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562648/

https://draxe.com/porphyria/

I had this coming out of my eyes, nose and I was urinating it. I never got diagnosed but I thought it was blood. I now think it was my body detoxing.

http://www.porphyriafoundation.com/testing-and-treatment/testing-for-porphyria/tests-for-porphyria-diagnosis

https://neuromuscular.wustl.edu/nother/porph.htm

http://www.townsendletter.com/July2017/krypto0717_2.html

Baking soda normalizes bladder ph and reduces uric acid levels.

https://www.ncbi.nlm.nih.gov/pubmed/29498467