Reducing uric acid/gout.

Written by Lee Stevenson, sorry I am not the best editor.

This is not medical advice I am writing this for educational purposes. Supplements should be taken with the guidance of a qualified and experienced naturopath.

If uric acid levels are high a person will react to things that contain purines like peanut butter and aged or fermented foods. Often time high uric acid levels can cause high ammonia levels. Uric acid increases TH17 levels so this can cause joint pain and deterioration and muscle wasting , fatigue because oxidative phosphorylation can become inhibited causing low ATP levels. A person well start developing food sensitivities. It may be necessary to avoid foods high in purines until a person has gotten their uric acid levels down. Uric acid can also cause kidney stones, it can damage the renals system and can cause interstitial cystitis, vaginosis and vulvadynia. Uric acid is needed by the body and in normal levels the body uses it as an antioxidant. Inflammation , oxidative stress, toxins, glyphosate and eating GMOs cause high uric acid levels. Vaccine injury can cause high uric acid levels. The covid injections are damaging the body in a way it is causing high uric acid levels. Uric acid increases renin-angiotensin expression when over expressed it causes cardiovascular disease. Mushrooms can increase uric acid levels. Processed sugar and fructose should be avoided. Excess alcohol consumption can cause high uric acid levels. If a diet is deficient in glycine or tryptophan it will increase uric acid levels. Proper sulfation is need to prevent high uric acid levels. Uric acid is needed to scavenge nitric oxide. Low hippurate levels can cause high uric acid levels. It is produced from consuming foods that contain phenylalanine and polyphenols and converted by our microbiota. High uric acid levels can cause obesity and diabetes. It can cause autoimmunity. Excess uric acid can cause gout and autoimmune diseases like lupus.

Excess stress or trauma can increase uric acid levels. Taking excess niacin can cause high uric acid levels. Meditation and simplifying life reduces levels of uric acid.

If the immune system has been damaged it can cause high uric acid levels.

High uric acid levels could be a sign that there is something causing excess cell death. The underlying cause of the high uric acid levels need to be addressed or taking supplements to reduce uric acid will not help.

Uric acid increases NADPH oxidase expression which can cause excess oxidative stress. High uric acid levels can be a sign insulin levels are too high.

Exercise reduces uric acid levels. Reducing intake of animal protein reduces uric acid levels.

Nitric oxide is low in those with high uric acid levels. This could be cause by metabolic issues or a diet deficient in nitrate or nitrites. Nitrates can be found in dark leafy greens and beet juice.

Foods that help reduce uric acid levels are pomegranate, artichoke, cherries, lemon juice, sprouts, celery, hibiscus tea, birch bark tea, berries, Brazil nuts, parsely, beans and legumes, celery, pumpkin, oatmeal, water mellon, coffee, milk, goat milk, walnuts, pecans, sugar cane extract, tomatoes, brewers yeast, broccoli, organ meats, and walnuts. Rooibos tea reduces uric acid levels. Foods high in potassium like bananas and citrus fruit reduces uric acid levels. Brown or black rice can help to reduce uric acid levels.

Vitamin C helps speed up the removal of uric acid from the body but high dose can actually cause the body to retain uric acid. Apple cider vinegar also reduces uric acid levels.

Consuming Omega 3 oils help to reduce uric acid levels.

Zinc low levels can impair the the urea cycle this can also cause high ammonia levels.

Alternate between magnesium citrate and magnesium chloride.

Wild yam, most species reduce uric acid including smilax.

Burdock root

Grape seed extract

Harpago phytum

Devil’s claw

Lemon grass

Baking soda a tablespoon in a cup of water. This should not be done too often or it can over alkalize the bladder.

Tumeric

jerusalem artichoke root or chicory root

Bergamot

Biacalein found in skullcap and plantain herb reduces uric acid.

Wild yam

B vitamins help to reduce uric acid levels except niacin in excess it can cause gout.

Low dose molybdenum

Betaine (trymethylglycine, TMG)

Pyridoxal 5-phosphate (P5P)

Alfalfa

Microbes that reduce uric acid:

Lactobacillus fermentum

Lactobacillus reuteri

Lactobacillus casei shiroto

Lactobacillus rhamnosus

Lactobacillus deulbrueckii

Lactobacillus deulbrueckii

Lactobacillus brevis

Lactobacillus gasseri

Most Bacillus species

Streptococcus thermophilus

Roseburia species

Rumminococcus species

Blautia species

Oscillospira species

Lautropia mirabilis

These species of microbes increase uric acid when overgrown:

Lactobacillus iners

Candida species

Pathogenic Clostridium

Escherica species

Desulfovibrio species

Klebsiella species

Pepotstreptococcus species

Corynebacterium species

Cryptococcus species

Poryphyromonas species

Morganell morganii

Parabacteroides species

Ralstonia species

Mirococcus species

Saccharomyces cerevisiae

Flavobacterium myroides

Vagococcus species

Turicibacter species

Bdellovibrio bacteriovorous

Mica vibrio

Parvimonas species

Teasel for joint health.

Written by Lee Stevenson,. Sorry I am a lousy editor.

This is not medical advice, I am writing this for educational purposes. If you are ill please seek the assistance of a qualified and experienced functional medicine practitioner.

Teasel (dipsacus spp)

Dipsacus fullonum is the species most are used to seeing but there are other species and because the phytochemicals are very similar I am going to speak about depsacus spp as a whole. Teasel contains a chemical that has been found to prevent soft tissue degeneration and reduce soft tissue inflammation. Most of the experiments with Dipsacus species have been on animals but my experience I have seen first hand many of those experiments to translate over to humans which is rare in animal experiments.

Teasel contains a chemical that helps prevent neurological and brain damage. Many species of teasel were shown to be effective against a variety of borellia species which causes Lyme disease.

Teasel is effective against many types of gut bacteria that causes inflammation and may be why it improves joint health and prevents joint inflammation. It also is effective against many types of fungus infections. Lyme can cause bone deteriation. Teasel has been shown to reduce bone deterioration.

Teasel has potent antioxidant and anti-inflammatory properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807821/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273713/

https://pubmed.ncbi.nlm.nih.gov/31936189/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020454/

https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/dipsacus

https://www.frontiersin.org/articles/10.3389/fphar.2021.615157/full

https://www.spandidos-publications.com/10.3892/etm.2017.5072

Dangers of high uric acid levels.

Written by Lee Stevenson sorry I am a lousy editor.

This is not medical advice and should not be taken as such. I am writing this for educational purposes if you are ill find a reputable naturopath who is knowledgeable and has a good reputation I do not recommend anyone treating themselves.

This is going to discuss how cells in our bodies respond to excess uric acid. Many do not see how serious the damage to the body uric acid does. It can lead to life threatening health issues. Gout is the least of the worries when it comes to uric acid.

When cells come in contact with uric acid they leak serotonin , ATP, ADP and there is a loss of lactic acid dehdrogenase, or beta-glucuronidase. When this occurs excess cellular lysis occurs. IgG is also released and immune complexes to be released. Now we will discuss what the consequences of each of these things occurring is.

The loss of cellular ATP and ADP will cause the body to have to switch to another source of energy. It is a very inefficient way for the body to produce energy so a person will experience fatigue and most likely experience weight gain. Those who are more chronic may experience sever weight loss. This also shuts down the citric acid cycle. Oxidative phosphorylation needed for many mitochondrial process gets shut down. This reduces the ability for the body to heal. This will also effect many hormones in the body and a person most likely will develop high estrogen levels. They may show symptoms of high estrogen but estrogen levels may be normal but progesterone levels will be reduce causing the same symptoms as estrogen dominance.

There is a loss of lactate dehydrogenase or beta-glucuronidase caused by the release of aggregated IgG or immune complexes. The loss of lactate dehydrogenase cause a loss of the ability to convert lactic acid to pyruvate resulting in acidosis. The body can no longer convert NAD to NADH and back. Lactate dehydrogenase is released during cellular injury, it prevents muscle failure and fatigue. It helps maintain proper ATP levels. Which farther adds to the fatigue a person will experience. Vitamin C taken in excess can also cause a loss of lactate dehydrogenase. Beta-glucuronidase is needed for the break down of complex carbohydrates for energy. Beta-glucuronidase converts bilirubin to unconjugated so it can be reabsorbed from the intestines so this can result in liver and kidney damage. There is a loss of glycosaminglycans (GAG) which is needed to maintain the health of the bladder, gut, membrane, blood brain barrier, cartilage, joint, bones, eyes and soft tissue in the joints. Loss of beta-glucuronidase causes the blood brain barrier to leak leading to brain inflammation and possible damage, interstitial cystitis, arthritis, connective tissue loss, damage to tendons and joints. It can also lead to leaky gut or gut inflammation.

Excess IgG in the blood stream causes the bodies immune system to turn on the body. This results in autoimmunity. This can lead to hepatitis, cirrhosis of the liver, connective tissue destruction, joint damage, systemic inflammation.

The excess serotonin in the blood stream causes irritability, agitation, restlessness, and anxiety. This can also cause muscle tremors, muscle rigidity, and muscle spasms, rapid heart beat, high blood pressure, excess sweating. A person may experience confusion, dizziness, or become disoriented.

This can be complicated even farther if someone take nicotinamide for the fatigue because it increases serotonin in the body.

The increased lysis caused by the uric acid causes the intracellular contents to leak into the blood stream, these are potassium, phosphate, and nucleic acids to leak into the blood stream. This results in hypercalcemia, hyperphosphatemia, hyperuricemia because this also increases uric acid levels, and acut kidney injury. Uric acid crystals and calcium phosphate crystals occur which are damaging to the body especially the renal system. This can lead to vaginosis and vulvadynia and cause interstitial cystitis.

Hypercalcemia (excess calcium in the blood) blocks sodium channels and inhibits depolarization, this can cause slower reflexes and muscle weakness, cardiac arythmias, fatigue, nausea, vomiting, kidney impairment, increased urination especially at night and increased thirst.

Hyperphosphatemia (excess phosphorous in the blood) can cause calcium depositsin the soft tissue, brain, lungs, eyes, arteries, muscles, and organs. This can result in organ failure. When it occurs in the muscles they become tender and lose flexibility. This can also result in damage to the heart valves.

Hyperuricemia can be caused by infection, gut inflammation , high glyphosate levels, eating processed foods which cause systemic inflammation, eating to many foods high in biogenic amines, issues in removing uric acid from the body, leaky gut which most do not realize they have. This can also result from gut dysbiosis especially if a person has to many microbes involved in protein proteolysis. Because the damage uric acid causes to the cells also increases uric acid levels it is a very difficult positive feedback loop to break. Uric acid is excreted in both the urine and intestinal tract. If we have inflammation in the gut or leaky gut the body cannot reduce the uric acid quickly enough. Insulin overload, iron toxicity can also increase uric acid levels. This is why it is very important to do our best to get uric acid levels down because things can rapidly decline and the higher levels get the harder the cycle is to break. Lithium helps break down the uric acid. Alkalizing the urine also helps to reduce uric acid levels. If there is an infection it must be addressed. There are many metabolic issues that can also cause high uric acid levels.

Smilax

Smilax

This is not medical advice and should not be taken as such. I am posting this for informational and educational purposes only. If in doubt don’t get to know a plant and it’s safety before using it.

There are many plants in the Smilax family in my area which is the eastern part of the United States. The ones I am familiar with are S. Ecirrhata, and S. Tamnoides. S. Tamnoides has briars on them that really hurt when jagged by them. We also have S. Glauca, S. Herbaceous, S. Rotundifolia, S. Pulverulenta, and S. Pseudochina in my area. I have eaten the leaves and like the taste. Many say the young shoots taste like asparagus. I have never eaten the roots but they are edible.

http://floridahillbilly.com/smilax-a-backyard-wild-edible/

http://www.eattheweeds.com/smilax-a-brier-and-thats-no-bull/

Most of them have the same phytochemicals that I am familiar with so they will be the ones I list studies on.

Has anti allergy properties.

https://www.ncbi.nlm.nih.gov/pubmed/26387391

fights cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351248/

http://cancerpreventionresearch.aacrjournals.org/content/8/5/464.long

http://www.mdpi.com/1420-3049/20/12/19890

https://www.ncbi.nlm.nih.gov/pubmed/26607178

http://cancerpreventionresearch.aacrjournals.org/content/8/5/464.long

Reduces inflammation

https://www.ncbi.nlm.nih.gov/pubmed/25817687

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363603/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585559/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244943/

Helps with pelvic inflammatory disease.

https://www.ncbi.nlm.nih.gov/pubmed/23353177

Protects against myocardial hypertrophy.

https://www.ncbi.nlm.nih.gov/pubmed/25926285

https://www.ncbi.nlm.nih.gov/pubmed/23954280

Cardioprotective

https://www.ncbi.nlm.nih.gov/pubmed/24953033

Has antimicrobial properties.

http://www.mdpi.com/1420-3049/18/5/5265

May have hepaprotective effects.

https://www.ncbi.nlm.nih.gov/pubmed/23681353

Contain Astilbin which is renal protective.

https://www.ncbi.nlm.nih.gov/pubmed/19644810

Contains steroidal saponins. Which has antifungal, and anti inflammatory.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507813/

Protects from lead poisoning.

https://www.ncbi.nlm.nih.gov/pubmed/20580805

Reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244943/

Contains taxifolin which has many health benefits. It is also known as dihydroquerciten. Too many benefits to list here.

https://www.ncbi.nlm.nih.gov/pubmed/12016952

Fights herpes and other viruses

https://pubs.acs.org/doi/abs/10.1021/jf030837o

https://www.worldscientific.com/doi/abs/10.1142/S0192415X08005692?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

https://www.ncbi.nlm.nih.gov/pubmed/16375860

Helps with gout

https://www.ncbi.nlm.nih.gov/pubmed/24140588