This is not medical advice I am posting this for informational and educational purposes.
If you truly want to heal it takes time and persistence. You have to develop your own protocol there is no one size fits all your protocol must be unique to you and your health problems. There is no magic bullet, pharmaceuticals treat the symptoms not the cause. So you may feel better but will slowly get worse until you will start needing other medications to hide the new symptoms that arise from the declining health which pharmaceuticals contribute to.
It takes a lot of research and patients. Take notes of what works and what does not and keep readjusting your protocol. As you heal your protocols will need to change. Homeostasis is the goal once you start feeling better try cutting supplements out. If it goes well then take a maintenance dose of the supplement once in a while.
Mucilage every few hours helps a lot with leaky gut. When you have leaky gut it causes high oxalate levels. This causes a cycle that is hard to break because oxalates prevent the gut from healing. Mucilage can help heal the gut breaking the cycle. Mucilage helped me the most with healing my gut.
Things that are high in mucilage are Okra, organic Oatmeal, Aloe Vera I found the liquid gel worked the best dried aloe vera seemed ineffective. Besella Alba known as Malabar Spinach, Irish moss but you have to watch consuming it, it has a cannabinoid that reduces pain but has side effects if you consume too much. Most plants in the mallow family are very high in mucilage and have very good healing properties. Most plants in the dioscera family are high in mucilage especially the chinese wild yam. Fenugreek is high in mucilage. Flax seeds are high mucilage but if you have leaky gut they should be ground up to prevent other heath issues. Most seaweeds are high in mucilage. Licorice root is high mucilage but you have to make sure it is deglycyrrhizinated if not it can cause many health problems. Mullein is high mucilage and helps with lung infections. Most edible plants in the daisy and sunflower family are high in mucilage. Wild Daisy helped me a lot. Pysillium seed husk are high in mucilage they are seeds from the plantain herb. Plantain herb itself is very high in mucilage. Wild violet is very high in mucilage. Chia seed is high in mucilage most seed is. Slippery Elm is high in mucilage but some claim it is high oxalate , I have never tried it. Most roots herbs are high in mucilage. Arrow root is very high in mucilage.
Various gut microbiome and what they do.
Oregano oil kills just about all pathongens in the gut.
Sage also is effective against bad gut bacteria.
Verbana fights Citrobacter. I don’t know much about it but it has sedative effects and helps with seizures.
Beta Glucuronidase is low it can effect hormones. If it is high it can cause toxins reabsorption.
High beta glucuronidase causes high estrogen.
Herbs that strengthen the immune system.
We also need to reduce oxidative stress and nitrositive stress.
Streptoccocus bacteria produce an exotoxins streptolysin and NAG -glycohydrolase which help it evade the immune system.
Inhibiting NLRP3 helps resolve the issues Streptolysin causes. It uses a tactic similar to Lyme disease it stimulates inflammation to evade the immune system.
Rabdosia contains oridonin which inhibits NLRP3.
There are a number of ways being used to inhibit NLRP3 inflammasome.
Resveratrol, quercetin and curcumin are NLRP3 inhibitors.
Paeonia is a CBR2 activator which inhibits NLRP3.
CB2R receptor activation protects and heals the nerves.
Hypoxia reduces NLRP3 and induces autophagy.
bacillus subtillus kills most bad gut bacteria.
We need butyrate producing bacteria to protect from inflammation. Also it protect the brain.
Fodmap diet helps with IBS.
Increasing Treg through FOXP3 cells helps.
Our gut bacteria regualate T Reg cells.
Mycobacteria can inhibit NOD2 which can cause gut issues.
Infection can lead to NOD2 deficiency this causes a reduction in V-ATPase which is needed to produce stomach acid.
Over stimulation of NOD2 can also make us prone to infections and chronic illness. Homeostasis should be the goal.
HSP70 Restores NOD2 function. I have posted on HSP70
Our diet and many probiotic strains can induce HSP70 which will restore NOD2 function which would restore dendric cell funtion.
Trypterygium Wilfordii may help restore NOD2 function though this is a single case report.
Our diet and our gut interactions.
Sulfation is involved in hormone production and use. Gut dysbiosis, glyphosate, mercury and other toxins can inhibit sulfation. This can result in hormone dysregulations. This can also result in high DHEA levels.
To much hydrogen sulfide producing bacteria lead to chronic illness.
Too many methane producing bacteria can lead to constipation there are some probiotics that will help with that.
The craziest part of all of this is I seen supposed pathogens that could correct many of these issues but did not include them in this but they turn certain genes of which could restore the function of non-functioning genes.
Diets effect on gut bacteria.
Tributyrin found in butter helps with dysbiosis
Sulfur regulation in the body is very improtant.
Dysbiosis often leads to impaired renal function.
Those who have gut issues will be deficient in short chain fatty acids and they are very important in maintaining our health.
Many will have high oxalate levels which are produced endogenously. I have posted on oxalates. This can prevent the gut from healing.
Autophagy corrects lipid metablolism which is needed to produce bile and digestive enzymes. Bile homeostasis is very important for the health of the whole body.
Hydrogen peroxide is needed for lipogenesis.
SOD increases H2O2. The only bioavialable source in food is the chaga mushroom.
Curcumin increase SOD but should not be taken too long it chelates iron and can cause anemia.
Sidt2 deficiency can inhibit autophagy. Unfortunately I have not research this Gene much.
Though I do not believe in taking enzymes the body can produce if all else fails what else are we to do. Often times taking enzymes the body can produce can disable the bodies ability to produce them.
Increasing brush oder enzymes helps with malabsorption.
You must heal the endothelium to correct malabsorption. Saccharomeyces Boulardii is needed for that. This also improve lipid abosorption.
Dietary nucleotide supplementation helps heal the digestive tract.
Mucins and tight junctions regulate what passes in and out of the intestines.
High zonulin levels causes the gut to become more permeable.
High zonulin levels has been linked to many diseases.
Probiotics to reduce zonulin.
colostrum reduces zonulin.
Brush border enzymes are needed to break down and absorb food.
Black Seed Oil improves carbohydrate digestion.
Thyme improves brush border enzymes.
How bile is secreted.
Foods that contain natural digestive enzymes.
They mention Kiwi in this one. It is high oxalate so would not be good for someone who has leaky gut.
I am sorry these are things I forgot to post with this post. It is concerning restoring the ability to produce short chain fatty acids.
Diasccharidase in involved in our digestion and absorption of carbohydrates and sugars. If we are not producing enough then our food will sit and ferment in our upper intestine possibly feeling like a brick is sitting in our stomaches. This will cause excess gas and can lead to the production of hydroxl sulfide which inhibits sulfation and can cause issues with the CBS and BH4 pathways. This can lead to high ammonia levels, proteinuria, phenyketonuria and even porphria. Infection can cause this, an imbalance in our gut bacteria brought on by farm chemicals especially glyphosate, antibiotics, and even chemicals found in processed food. If you have diarrhea and you are not absorbing then you may be producing too much disaccaride which is an indication of high insulin levels. High oxalates will prevent the gut from healing. I have posted on oxalates and the gut. If we produce too much diasaccaride then we will experience similar symptoms only instead of being constipated we would have diarrhea.
Vinegar seemed to help me but this studies shows it actually reduces Disaccharidase. Not sure what to think about this one.
We know those with IBD usually have high insulin levels showing they have lost their sensitivity to insulin. This leads to high leptin levels.
I know those with IBD connot do some of these things. You have to learn to figure out what in the information that is out there you can apply and what you cannot.
Though being insulin resistant is usually found in obesity it is common in many inflammatory bowel disorders.
Increasing insulin sensitivity will help with leptin levels.
Increased insulin levels inhibits disaccharidase levels.
Decreased insulin levels increases disaccharide levels.
Now if you look at MAPK it is involved in IBD. So now we can see the connections. We need to increase insulin sensitivity . I read many research articles and decreasing insulin levels seem to make IBD worse but improving insulin sensitivity improved IBD. Inhibiting TNF-a improves insulin sensitivity.
There are naturals that inhibit TNF-a but nothing that inhibits it directly. Also inhibiting it for too long makes us more prone to infection.
Resvertrol inhibits TNF-a it is found in grape seed extract.
Reducing insulin levels reduces P38 MAPK which reduces symptoms of IBD.
Those who have IBD have been found to be deficient in bacteria in the up digestive track especially Oscillospira and Akkermansia.
Lactobacillus Fermentan increases Akkermansia.
Host microbe prebiotic and fiber interactions. Interesting lets you know how each type of saccharide effects the gut bacteria.
Studies confuse me, some says stay away from carbohydrates will others show that those carbs increase the very bacteria those who have IBD are deficient in.
Beta Glucan found in Oats and mushrooms increases Oscillospira.
Meditarrian diet can increase Oscillospira.
L-arginine has been found in many studies to help normalize the gut bacteria even in chickens.
Nanosilver can kill specific gut bacteria depending on the size and shape. In theory this could be used to reduce specific gut bacteria that may be too numerous.
The shape of the silver determines which bacteria it is effective against.
Glutamine reduces Oscillospira which would be detrimental to IBS.
Black Raspberries increase Oscillospira.
Most with IBD are difficient in Oscillopira. This is found in the upper digestive tract. I believe it is the cause of the low disaccharidase production but I cannot find studies to prove it.
A deficiency in Oscillopira causes food allergies.
Food additives have a negative impact on the gut.
This is a good list of bacteria and what they do. Bifidobacteria Bifidum and Breve increase short chain fatty acid production.
Our gut bacteria regulate cell that produce antibiotics.
More on Oscillopora.
Bile acid also increases Oscillopora.
Gut homeostasis is controlled by the endocannbinoid system. Those with inflammatory bowel issues have been found to have low endocannbinoids. This raises diaglycerols which can prevent the proper production of digestive enzymes leading to the inability to digest and absorb saccharides and produce short chain fatty acids (carbohydrates and sugar). This is caused by the upregulation of the protein kinase pathway.
Black pepper increases endocannbinoids which would help with IBD.
HSP70 is a transport for anamide and other endocannabinoids. I have posted on HSP70.
FAAH inibitors increase endocannabinoids.
Biochanin A found in read clover, the red covering on peanuts, and in chick peas is an FAAH inhibitor.
Here is information on other cannabinoids and their effects on the body.
Kaempferol found in pine tree bark extract and magnolia is an FAAH inhibitor.
Bilirubin is inhibited with IBD and other inflammatory bile diseases. This is cause by the inflammation which can lead to scarring and obstruction of biliary ducts. Serrapeptase helps remove scar tissue and so doe HSP70. Also using anti-inflammatory herbs helps.
This is the oddest part about IBD and other inflammatory diseases. TMAO is low in those who have an intestinal inflammatory disease. Most have too much of the bacteria that produces TMAO but those with IBD have too few.
This is a list of gut bacteria that increase TMAO consuming choline will increase these bacteria.
Faecalibacterium Prausnitzii has been found to be low in those with inflammatory bowel disease. This causes a dificiency in nicotinic acid which leads to an increase in phenylalamine. This lead to a conditions called phenyketonuria which causes high ammonia levels in the body and can effect many metabolic pathways and cause us to become ill when we eat meat, potatoes or anything else that has phenylalanine in it. A deficiency in Faicalibacterium Prausnitzii also results in high cadaverine and putrescine levels which causes inflammation.
Our gut bacteria need iron tho thrive but the iron they fortify food with is the wrong type. Iron found in curly dock and burdock root will supply you with iron without causing toxicity unless you have certain liver diseases. If you have iron toxicity lactoferrin will restore iron homeostasis. Curcumine will reduce iron levels in the blood also but do not take it too long or you can become anemic.
Ghrelin stimulates our appetite and increase stomach acid.
Fatty acid and vagus nerve stimulate ghrelin.
I had to alternate types of diets until I got things straightened out. I had to do a FODMAP diet first then as I healed I had to switch to a Paleo diet. Then when I had healed enough I was able to fast it took me a while to build up to being able to fast for a day. Some can go longer and it is dangerous for others like those with lysosomal storage issues.
Hydrogen Sulfide produced by gut bacteria can cause sulfation issues.
When we have too much hydrogen sulfide being produce by our gut microbiome it will cause us to become constipated.
now you have reached a state that has caused a cycle that is hard to break and results in ulcerative coalititis and even IBS.
Excess H2S causes low blood pressure and a reduced body temperature. It will slow our metabolism causing us to feel drowsy.
The inhibited phosphorylation causes a deficiency in the redox ions needed by many metabloic pathways. Mainly Mg2+, Mn2+, Zn2+ and indirectly Ca2+. So it pretty much shuts cellular function down.
Not all will get drowsy with the inhibited phosphorylation it may cause NMDA issues which is what happened to me. When this happens and your glutamate levels sky rocket it will fell like your head is going to spit open, you will not be able to sleep and you will experience anxiety.
This thread is long enough but the can effect the CBS and BH4 pathways which can lead to sulfur intolerance and meat intolerance. Even after correcting this problem you have to heal the gut and get the oxalates down to restore the function of the metabolic pathways.
Having to many H2S producing bacteria has been shown to raise blood levels of H2S. I could not find studies on the prolonged effects but I have found information on prolonged exposure. It causes sulfhemoglobin which cannot be broken down by the body.
Thiamine and B6 deficiency can cause high oxalates.
the gut and cholestokinin
Trypsin inhibitors increase cholecystokinin.
Things that raise GABA like , mugwort, wormwood and rooibos reduces cholecystokinin levels. High estrogen levels cause high cholecystokinin levels. High dopamine levels increases cholecystokinin. High levels of cholecystokinin causes glutamate toxicity and NMDA toxicity.
Potatoes increase cholecystokinin
If not addressed it leads to autism.
Proprionate is high in Ibs. This strikes me as odd because acetate and butyrate are low in IBS. How can one short chain fatty acid be high and the test dificient?
High proprionate can cause loss of appetite and weight loss.
it is from having to high of bacteroides.
This article partially explains the high bacteroides levels.
Meat increases bacteriodes.
meat alkalizes the gut so it makes sense that those with IBD may consume more meat which will make them have raised bacteroides levels. This can lead to many health problems.
Betaine reduces bacteriodes by increasing stomach acid.
Snail1 involvement in inflammatory bowel diseases indicates macrophagy issues.
Macrophagy issue also cause lipogenesis issues.
Glycolysis issues are also an indication of inhibited macrophagy and sure enough those with inflammatory bowel disorders have glycolysis issues.
Macrophagy genes have been impicated in inflammatory bowel disease.
Good information from my friend David Anderson.
For people with digestive issues
Hydrophilic colloidal diet
1. Hydrophilic colloids bring about conditions in the stomach during digestion which approach those resulting from the consumption of foods in their natural state.
2.Hydrophilic colloids lessen gastric irritation by absorbing the digestive secretions of the stomach so that digestion takes place within a mass of food.
3. Gelatin, because of its availability, relatively low cost, non-toxicity, adaptability as an item of dietary and its thorough digestibility becomes an admirable hydrophilic colloid for dietary usage.
4. The amount of gelatin to be used in a given case depends on the patient’s needs, but it must be of good quality and sufficient in amount.
5. It has a wide range of usefulness in gastrointestinal ailments ranging from the atonic conditions met in the chronic invalid to the irritating condition presented in gastric ulcer.
In some instances, gelatinized arrowroot powder has been used to achieve similar results.. Arrowroot/pectin, etc… Could possibly be used if oxalates are an issue.
Medium chain triglycerides improve bile flow and decrease bile reabsorption.
MCTs help heal leaky gut and inflammatory bowel disorders.
Organic acids help heal the gut mucosa.
They recommend glutamate in this. That is not correct because those with inflammatory bowel issues have high bacteriodes and glutamate feeds them which can make things worse. But there is useful information in this.
There is an error in this. Those with inflammatory bowel have high bacteroides which causes a lot of problems. They claim glutamate helps but it feeds bacteroides so would make things worse but I found useful information in this.
Interesting information on inflammatory bowel disease.
Those with inflammatory bowel issues are low in biotin which is probably caused by the inflammation inhibiting absorption.
A biotin deficiency causes the inability to break down proteins, fats and other nutrients.
Those with inflammatory bowel usually have low biotin which can cause many metabolic issues. Biotin needs Adenosylcobalamin which is a form of B12 in the body. Some may have to supplement if the body is not converting it.
Adenosylcobalamin helps with biotin absorption and use.
Biotin and pantothenic acid compete for absorption and pantothenic acid can inhibit biotin absorption.
Alkaline Phosphotase is low in those with inflammatory bowel disorders. Lactobacillus Casei increases it and will help with nutrient absorption.
Before increasing it make sure you know the dangers of too much.
How to increase ALP.
If you take curcumin once the gut bacteria start getting established stop taking it. It can cause anemia because it chelates iron.
Cissus stimulates ALP.
High estrogen levels effect bile production. Bile protects the intestines from inflamation.
Hormones involved with bile flow.
Inhibited bile flow can cause estrogen dominance.
This causes a cycle that is hard to break and results in high cck levels.
Activation of the CCK1 receptor by estrogen can lead to gall stones.
Dim3 (diinoylmethane) inhibits the estrogen receptor which should lower cholestokinin levels.
Things that inhibit Era.
They mentioned soy isoflavons in the previous study but it could make things worse.
ursolid acid that was mentioned is found in the wax on skins of apples , in rosemary and thyme.
These are enzymes and hormones that are usually dis-regulated in inflammatory bowel.
Cholesterols function in bile secretion. Issues with the liver X receptor can cause issues with cholesterol metabolism.
Olive Oil help resolve liver X receptor issues. But inhibits glucuronidation.
Butyrate found in butter and ghee also help.
High estrogen inhibits sulfation. Increasing UDP-glucuronosyltransferases will reduce estrogen levels.
DHA, oleic acid, and linoleic acid inhibit those enzymes.
Foods that increase UDP-glucuronosyltransferase.
Luteiolin is good at increasing UDP-glucuronosyltransferase.
Diosmetin is found in the white parts of citris fruit and dates.