This is not medical advice I am posting this for educational and informational purposes.
There are many things that can cause pain. It is usually a synergistic effect of things that have built up and caused high inflammatory cytokines, mast cell activation syndrome, high substance P levels, even metabolic issues can cause pain. I have posted on those things and to reduce pain and start healing they must be addressed. I have much more detailed notes on reducing pain but figure this would be a good start.
Many pain killers have been linked to chronic illness , for example tylenol has been linked to liver disease along with many pharmaceuticals for pain. Opoiods have been shown to increase inflammation and add to pain. Even steroid injections have been found to make things worse.
This is a list of things that can cause inflammation which leads to chronic pain. I have posted information on most of these.
http://www.biology-pages.info/I/Inflammation.html
Coffee acts as an opioid. Those with carditits or tachycardia are supposed to avoid caffeine.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546775/
Vitex acts on the opioid receptors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993511/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081944/
CBD and PEA help with gut pain and inflammation.
http://www.clinsci.org/content/131/21/2611.long
https://www.sciencedirect.com/science/article/pii/S0028384317303249?via%3Dihub
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531370/
https://www.sciencedirect.com/science/article/pii/S0028384317303249?via%3Dihub
PEA has also been found to help with bladder pain. But if a person has pyrrole issues which is usually a symptom of porphyria they should address those issues before taking any type of fats. If they do not it can irritate their bladder. It will also cause a type of acid reflux.
Interstitial Cystitis (IC), bladder pain syndrome (BPS), its cause and treatment
How endothelin contributes to pain and inflammation. Endothelin is usually increased under nitrosative stress. I have posted on it. Increased endothelin levels can lead to high blood pressure. So when high we should try and reduce them. High Indothelin levels can cause asthma, diabetes and cardiovascular disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630124/
https://www.selfhacked.com/blog/endothelins/
mTOR inhibitors reduce endothelin. I have mentioned mTOR in other post if you do a search in my profile.
https://www.jhltonline.org/article/S1053-2498(16)00574-X/fulltext
http://diabetes.diabetesjournals.org/content/60/8/2061
Endothelin is high in cirrhosis of the liver and COPD.
http://www.clinsci.org/content/105/2/227
https://www.resmedjournal.com/article/S0954-6111(03)00129-X/fulltext
High substance P levels can cause mast cell activation syndrome, inflammation and pain. I have posted on substance P. Magnesium helps reduce endothelin.
http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1933737
https://www.wellnessresources.com/news/magnesium-is-essential-for-preventing-substance-p-overload
http://www.drwardbond.com/dr-bs-blog/trichodynia-pain-and-substance-p
http://mcr.aacrjournals.org/content/11/3/294
Chamomille reduces substance P.
Cox increased pain and inflammation. Natural Cox inhibitors reduce pain and inflammation.
http://www.chiro.org/nutrition/FULL/Natural_COX-2_Inhibitors.shtml
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873812/
Nutmeg is a Cox inhibitor and reduces pain. It has a potent canidbinoid that can cause hallucinations, seizures and even death if taken in to high amounts.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848392/
Opium Lettuce also known as wild lettuce has a natural pain killer in it that is non addictive. It is similar to opium and has been used to break opium addiction and has been shown to reduce withdrawal. It also reduces inflammation. The only toxicity I have seen is when people have purified the sap and smoked it. Also a few who consumed much too much. There were no fatalities that I could find documented.
https://www.herbs2000.com/herbs/herbs_lettuce_opium.htm
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031874/
https://returntonow.net/2017/10/11/opium-lettuce-natures-best-painkiller-growing-backyard/
Aloe Vera is neuroprotective and reduces inflammation.
http://www.em-consulte.com/article/1043973/alertePM
This one actually surprised me. I set out to prove that using magnets for pain and inflammation was crazy. I found none that showed no effects and most studies showed magnets improved blood flow , promoted healing and reduced inflammation.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818436/
Additives in food, drugs like fluoroquinolone, farm toxins which have been found to be high in our food supply can cause high glutamate levels. This cause headaches, anxiety, difficulty sleeping, inflammation and systematic pain.
https://healthyeating.sfgate.com/glutamate-pain-8891.html
Vitamin C can alleviate pain but in high doses it can cause oxalates and break down read blood cells.
https://www.ncbi.nlm.nih.gov/pubmed/28902622
Many things can set off a cytokine storm. This causes systematic inflammation and pain. Vaccine injury is a major contributors along with farm chemicals found in our food. Food additives and processed sugar also causes inflammation. I have posted a list of naturals that reduce inflammatory cytokines.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785020/
https://www.hindawi.com/journals/cripe/2017/9461315/
This woman listed things that helped her friend with interstitial cystitis pain. All the things she mentions also helped me.
https://hubpages.com/health/Interstitial-Cystitis-Life-Without-Pain
If you have certain metabolic issues like protenuria, porphyria or sulfation issues which they claim is genetic but I have seen many recover from it when they have detoxed fluoroquinolones or glyphosate. Some may have to avoid meat for a while until they correct the metabolic issues.
https://www.youtube.com/watch?v=SaQpaJ-azKk
Toning the vagus nerve can reduce pain.
https://upliftconnect.com/toning-vagus-nerve-heals-pain/
Oxalates cause a lot of pain and inflammation. They can be produced endogenously. The problem with endogenous oxalates they block metabolic pathways causing even more oxalates to be produced. It becomes a cycle that is difficult to break. Oxalates cause leaky gut which adds to the oxalate burden by permitting oxalates that are consumed to enter our blood streams. Another thing that contributes to high oxalates is a loss of the oxalate digesting bacteria from our guts. The loss of oxalate digesting bacteria is caused by antibiotics and farm chemicals in our foods. Also heavy metals found in food grown in contaminated soil can kill our oxalate digesting bacteria. Oxalates prevent the gut from healing making the cycle even more difficult to break. I have posted on how to overcome this.
https://www.alwayswellwithin.com/2010/04/27/high-oxalate-foods-can-trigger-pain-and-inflammation/
https://myersdetox.com/oxalates-their-influence-on-chronic-disease/
https://functionaldiagnosticnutrition.com/top-signs-you-may-have-oxalate-sensitivity/
Lacking certain gut bacteria and having to many of others can cause pain.
http://atm.amegroups.com/article/view/13313/13673
https://www.healio.com/gastroenterology/irritable-bowel-syndrome/news/online/{bb454dd3-01bf-4720-a01e-912c62d09062}/probiotic-yeast-improves-abdominal-pain-bloating-in-ibs-c-patients
https://www.nature.com/articles/srep26083
https://www.nature.com/articles/nm1521
Even in sickle cell the gut has been linked to pain.
Mugwort is an amazing plant. It has been shown to heal the liver, brain, and reduce inflammation. It increases GABA which reduces pain. It kills many pathogens and has been shown to be very effective against cancer.
There are many different cannabinoids found in a variety of plants. The most well known is found in cannibis. Not all benefit from the cannibinoids in cannabis. But many do and it has been shown to be extremely effective against cancer.
https://www.naturalhealth365.com/chronic-illness-cbd-2276.html
Cannabinoid in carrots and parsley, reduces inflammation and pain.
https://www.ncbi.nlm.nih.gov/pubmed/20206138
Magnolia contains a cannabinoid that reduces pain and inflammtion.
A-Pinene is a cannibinoid found in pine and it reduces pain and inflammation.
https://www.ncbi.nlm.nih.gov/pubmed/26119957
https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-135
Lemon grass contains myrcene which is cannabiniod like.
https://www.ncbi.nlm.nih.gov/pubmed/1753786
Exercise helps release endogenous cannabinoids.
http://jeb.biologists.org/content/215/8/1331
Many things they claim are genetic can be corrected and I have posted on that. Things that may be genetic usually do not present themselves unless a number of issues have built up and cause a synergistic effect. Correcting those problems usually will stop any the supposed flawed gene from presenting itself.
http://www.beyondmthfr.com/a-genetic-cause-of-pain-and-anxiety-comt-mao-and-mthfr/
Drugs are one of the major causes of damage leading to pain in the body. Statins and fluoroquinolones are two of the major culprits.
https://www.healthline.com/health/what-is-statin-induced-myopathy-or-muscle-pain
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/766834
I have covered mTOR in other post. High mTOR levels can be a cause of pain and inflammation and has been found to be high in many inflammatory diseases.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084610/
Interstitial Cystitis is like all forms of chronic illnesses rolled into one. Studies have found that it is best to listen to the patient on what works and what does not. Also they have shown naturals work better.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783700/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772357/
I was never one to leave them inject me with steroids. All those I knew who got steroid injections I would see a dramatic decline in their health shortly after so I have no confidence in their safety or effectiveness.
High adrenal levels can be the result of toxins, vaccine injury, excess stress or infection. It has been found to be common in those with inflammatory diseases.
https://onlinelibrary.wiley.com/doi/abs/10.1002/nau.22542
Mindfull meditation has been shown to reduce pain.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067184/
It is very important to try and get over trauma because it can lead to chronic pain and health issues.
https://www.ncbi.nlm.nih.gov/pubmed/28107899
Increased BH4 levels can raise pain levels. They inhibit it in this study which can have many negative health effects. I have posted on correcting BH4 by taking the nutrients needed to support it. Upregulated BH4 also upregulates the CBS pathway. This can effect the Pentose Phosphate Pathway which can lead to diabetes, heart disease and arteriosclerosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288148/
TMJ a disorder where there is pain in the jaws can be caused by infection especially tick born illness. Lyme disease and some tick born illness that can be even worse can cause systematic illness.
http://www.tmj.org/site/page?pageId=193
https://canlyme.com/lyme-basics/symptoms/
Mold
https://www.merckmanuals.com/home/infections/fungal-infections/mucormycosis
Tylenol is very hard on the liver. There are safe natural alternatives to tylenol.
https://jennifermargulis.net/tylenol-alternatives-better-safer-remedies/
Botox has been found to help those with severe bladder pain.
https://health.clevelandclinic.org/botox-can-offer-women-help-painful-sex/
Acetyl-L-Carnatine has been shown to help with neurological pain.
Lyme and other tick born illness effects the whole body. That is why many with Lyme have interstitial cystitis.
https://lymemd.blogspot.com/2009/06/interstital-cystitis-and-lyme.html?m=1
Lyme treatment often times fails that is why many of us turn to alternatives.
http://danielcameronmd.com/5548-2/
When getting treated for infection it can set off sepsis which I covered under my endotoxemia post. Sepsis can set off mast cell activation syndrome which causes high histamine. It can also cause high substance P levels, high mTOR levels and set off an inflammatory cytokine storm. Vaccine injury can also do this. When getting treated for infection it is safer to start at low doses and slowly work up to higher doses. This also includes when taking naturals for infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111180/
NSAIDs can damage the gut if taken for too long which can lead to many forms of chronic illness.
https://jeffreydachmd.com/2014/06/nsaids-small-bowel-leaky-gut/
Cissus has been shown to reduce pain.
https://www.organicfacts.net/health-benefits/other/cissus-quadrangularis.html
This article discusses the immune system and how it can lead to chronic pain. I have posted on the immune system with links on how to balance it.
https://phoenixrising.me/archives/13083
Pau D Arco helped me a lot. Fights inflammation and many pathogens including mycoplasma.
https://draxe.com/pau-darco-tea/
Most plants in the Mallow family reduce pain and inflammation.
Rooibos is an amazing herb it kills infections especially in the lungs and reduces inflammation and histamines.
Bacopa is another amazing herb that reduces inflammation , heals blood vessels and has many other benefits.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319078/
I do not like supplementing things the body can produce but in some instances supplementing may be necessary. Melatonin has many healing properties. There are ways to stimulate melatonin production.
http://www.fupress.net/index.php/ijae/article/view/21483
Feverfew reduces pain, fights the flu and common cold. It can be addicitive and cause withdrawal called toxic withdrawal syndrome if taken for too long.
https://www.drweil.com/vitamins-supplements-herbs/herbs/feverfew/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309307/
A variety of plants and their effects on pain. I seen lemon balm mentioned many of my friends said it has helped them.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597072/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111180/
https://nourishholisticnutrition.com/herbs-to-reduce-insomnia-and-chronic-pain/
https://www.health.harvard.edu/staying-healthy/foods-that-fight-inflammation
Japanese honeysuckle reduces inflammation and histamines.
https://www.hindawi.com/journals/ecam/2015/905063/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923575/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765429/
With some types of illness we can develop high glutamate levels. This can make it feel like our head is going to split open. Burdock root can reduce the symptoms of high glutamate levels.
https://www.ncbi.nlm.nih.gov/pubmed/24956398
Purslane is a super food. It has almost all nutrients needed by the body. It reduces inflammation and is very high in mucilage which heals the gut.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321094/?report=classic
Wild Violet has neuroprotective properties.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967839/
https://www.sciencedirect.com/science/article/pii/S0378874112007362
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613244/
Passion Flower has been shown to reduce pain and have neuroprotective effects but I have seen studies that have shown it can damage the liver though it was not clear if it was reversible or the amount of passion flower that was used. I know many who have used it and said it really helped them but once they healed they discontinued use. I would not recommend frequent or high dose usage.
https://www.ncbi.nlm.nih.gov/pubmed/27693740
Yarrow has pain killing properties and reduces inflammation. Should not be used before bed because it has stimulant effects.
http://www.medicalmedium.com/blog/yarrow
https://wellnessmama.com/7106/yarrow-herb-profile/
Our gut bacteria reduce pain by modulating the opioid and cannabinoid receptors.
Even some of our gut bacteria modulate the opioid and cannabinoid receptors.
https://www.ncbi.nlm.nih.gov/pubmed/17159985
https://www.ncbi.nlm.nih.gov/pubmed/17159985
Symptoms of gall bladder problems.
Symptoms of gallbladder problems.
Acute pain, possibly very severe, that occurs very suddenly. It may last a few minutes, or many hours
Pain is usually located behind your breastbone, but may occur in the upper right abdominal area
Pain between your shoulder-blades
Chills and fever
Jaundice
Nausea and vomiting
Many of the things in this list help reduce my pain.
http://naturalsociety.com/16-natures-best-natural-pain-killers/
Sunlight reduces pain.
https://www.ncbi.nlm.nih.gov/pubmed/27717401
Problems with the vagus nerve which can result from toxins, infection, stress and bad diet can cause chronic pain.
https://upliftconnect.com/toning-vagus-nerve-heals-pain/
This one do your research on. Some things mentioned can have ill effects for some for example SAM-e causes me many problems.
https://www.prohealth.com/library/13-supplements-to-control-lyme-pain-6637
Bad fats cause inflammation.
https://www.drgangemi.com/health-articles/diet-nutrition/nsaids-and-inflammation/
Wild Daisy helps with anxiety but it helped me with pain.
http://www.academicjournals.org/journal/AJPP/article-abstract/176846033725
resveratrol found in grape seed extract reduces bradykinins which can cause inflammation.
https://www.tandfonline.com/doi/abs/10.1517/14728222.11.1.21?journalCode=iett20
Brown seaweed helps with neuropathic pain.
https://www.sciencedirect.com/science/article/pii/S0304394014003413?via%3Dihub
Many sources of pain can be identified by a chiropractor who knows the human body better then most doctors.
https://draxe.com/piriformis-syndrome/
https://www.spine-health.com/conditions/neck-pain/neck-pain-lyme-disease
How our genes can be the cause of our pain.
http://www.beyondmthfr.com/a-genetic-cause-of-pain-and-anxiety-comt-mao-and-mthfr/
Tryptophan decreases pain.
http://healthiculture.com/fibromyalgia-pain-relief-tip-tryptophan/
I have never tried arnica but many of my friend said it has helped them.
Some have found relief using pectin , it helped me.
http://healthiculture.com/fibromyalgia/painrelief/15pectin/1.php
Nutrient deficiencies can cause pain.
http://www.encognitive.com/node/12179
St. Johnswort reduces pain inflammation and has antioxidant properties. I seen studies that claimed it was toxic to the liver. Those studies where vague as to methodology and lacking data. Most studies I have read on St Johnswort showed it to be non toxic and does the opposite it actually reduce inflammation in the liver.
https://www.ncbi.nlm.nih.gov/pubmed/25851311
https://www.karger.com/Article/Pdf/21265
https://draxe.com/st-johns-wort-uses/
I have never tried Kratom but many of my friends have and they have really benefited from it. They claim it is addictive but none of them became addicted. I do know something in the kratom that is green irritates IC sufferers bladder and my friends said the red kratom did not irritate their bladders.
Thunder God vine has been used by some but I am skeptic because it takes someone knowledgeable to prepare it and there have been incidences of people being poisoned by herbs being prepared wrong.
https://www.drweil.com/vitamins-supplements-herbs/herbs/thunder-god-vine-for-pain/
Rhodiola helps with endurance and many said it reduced their pain.
Galinsoga Parviflora
Lee's Stuff 
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