Written by Lee Stevenson, sorry I am not the best editor.
This is not medical advice I am writing this for educational purposes . If you are ill you should seek the aid of a qualified and experienced naturopath.
Types of nucleotides and their beneifts. Just a note. Nucleotides require nitric oxide to form. Many are produced in the body but can be acquired through food.
Adenosine- It is used by the body to produce ATP. Adenosine improves sleep quality. It’s levels increase throughout the day. Exercise and doing mental puzzles or solving problems increases adenosine. It is produced through the bodies production and use of ATP. So increasing ATP will increase adenosine. Those who avoid solving problems or avoid certain types of stress instead of finding solution inhibit their production of adenosine. This can cause them to have low quality sleep.
Adenosine prevents excess blood clotting. It promotes the break down of glycogen to glucose which is the main source of energy for the brain. It increases fat burning and prevents fat retention which prevents obesity. It prevents diabetes and glucose intolerance. It improves muscle function, prevents muscle fatigue and increases muscle growth. Adenosine is one of the building blocks for DNA and RNA. Adenosine prevents heart arrhythmia, prevents cystic fibrosis, Promotes the growth of hair and increases hair thickness. It protects the body from the effects of low oxygen levels. Adenosine prevents sleep apnea, adenosine prevents hypertension by increasing nitric oxide. Adenosine reduces pain in the body. Adenosine counter acts the effects of oxidative stress. Adenosine improves the healing of tissues throughout the body. Adenosine protects the brain from the effects of age related diseases such as Parkinson’s and Alzheimer’s. Adenosine prevents diabetes and glucose intolerance. Adenosine improves the health of the HPA. Adenosine can reverse the effects of aging. Adenosine increases VEGF which is low when someone has experienced trauma, stress, infection, sepsis or have CIRS. This would help to speed up their healing. Adenosine prevents the an over active immune response which would prevent autoimmunity. Excess adenosine can increase the risk of cancer and prolong sepsis. Adenosine is usually high in sepsis. This is from ATP production being inhibited which prevents the body from clearing adenosine. Those with high adenosine have difficulty waking in the morning and will feel tired throughout the day.
Symptoms of low adenosine are fatigue, muscle weakness and atrophy or muscle wasting, skin problems like rashes, inflamed skin or dry skin, depression, anemia, frequent infections, vertigo, allergies.
Inceasing ATP which provides energy for the cells increases adenosine. ATP should be increased in the morning. As ATP is used adenosine is produced. Things that increase ATP are CoQ10, L-carnitine, D-ribose, niacin, folate, P5P in moderation, over consumption of 100 mg can have the opposite effect. Omega 3 oils, copper is needed for adenosine production, SAMe increrases ATP, Increasing anandamide increases adenosine. Anandamide is one of the most potent endogenous cannabinloids it reduces pain and inflammation and give the euphoric feeling. It is increased by consuming Omega 3 oils, eating berries, apples, grapes, lettuce, peaches, cumcumbers, spinach, potatoes, and onions. Black truffles contain high levels of anandamide. DIM (diinolymehtane) found in cruciferous vegetables increases anandamide. Creatine can increase ATP levels. Cordycep mushrooms, panax gensing, also increases ATP levels.
Cytidine also known as citicoline. Citicoline protect the brain from the negative effects of glutamine and improve function of the NMDA receptor which would help with autism. Citicoline has been shown to reduce withdrawal from addictive drugs. Citicoline improves urinary function and health. Citicoline prevents depression and anxiety. It prevents viral infection and E coli infection. It has been shown to help prevent glaucoma and improve overall eye health. It improves brain function by increasing the repair and growth of cells in the brains and nerves. It is a potent anti-inflammatory. It improves mood by increasing acetycholine and dopamine which gives a person more motivation, and a more positive outlook. Citicoline improves muscle strength and endurance. Citicoline improves blood circulation. Citicoline improves memory. Citicoline helps prevent leaky gut and a leaky blood brain barrier. Citicoline prevents excess lipid peroxidation.
Citicoline is found in organ meats, eggs, fish, beans, cauliflower and broccoli. If taken in supplement form no more then 600mg should be taken.
Uridine- supports the production of dopamine, serotonin and norepinephrine which would improve mood and prevent inflammation. It works synergistically with Omega 3 oils and choline so it would be more beneficial if taken with those nutrients. Urindine increases ATP levels which prevents fatigue. Uridine improves exercise endurance. It improves brain function even under low oxygen levels. It prevents the negative effects of toxins such as mercury on the brain. It enhances brain function. It improves mitochondrial function and improves energy production by the mitochondria. It has been shown to prevent depression and bipolarism. Uridine improves sleep quality. It increases neuroplasticity which improves the brains ability to learn and adapt. It increases alertness and mental focus. Promotes the repair and growth of neurons. Reduces symptoms of cystic fibrosis. Helps restore the production of tears in those who have dry eyes. It helps to improve the heart rhythm by increasing ATP. It improves liver health and promotes the regeneration of the liver. Reduces pain and inflammation. It improves the tolerance to milk and milk products.
There are severe side effects so it is best acquired from food. High levels of uridine can cause scarring on the heart and increase the risk for cancer. It can cause insulin resistance. 1 to 2 grams a day is what was used in studies but most claim 500 to 1000 mg is the safest amounts if taken in supplement form.
Food sources of uridine are brewers yeast, nutritional yeast, mushrooms, oats, broccoli, organ meats, fish, beer, goats milk, sugar cane extract, and tomatoes.
Guanosine (guanylic acid) – It is needed for the production of healthy RNA and DNA. It prevents infection by RNA viruses. It prevent uncoupling of OXPHOS. OXPHOS is needed for mitochondrial production of ATP so it would improve mitochondrial ATP production. It improves the function of the citric acid cycle needed to produce energy for the body. It prevents obesity, diabetes and glucose intolerance. It prevents the exitotoxic effects of glutamate in the brain. It increases adenosine which improves sleep quality. It has anticonvulsant effects. It improves the health of the hippocampus so would improve HPA function. Guanosine decreases oxidative stress and inflammation. It has been shown to reduce brain inflammation. It reduces ammonia in the body. It dramatically reduces the symptoms of sepsis. It reduces pain in the body. Guanosine prevents depression and anxiety. It helps to reduce symptoms of schizophrenia. Guaonosine protects the brain from the negative effects of low glucose and low oxygen levels. Guanosine increases expression of APOE which would improve fat soluble vitamin levels, improve fat and cholesterol levels in the body. This also would help to prevent Alzheimer’s. It increases Heme-oxigenase which would reduce oxidative stress and improve mitochondria function. It upregulates klotho which reverses aging and heals the liver and kidney. It reduce uric acid levels in the body which would help with gout. It prevents muscle weakness, and fatigue and increases muscle growth. Guanosine reduces the risk of cancer. It improves mitochondrial fusion which improves mitochondria health and DNA health. Guanosine inhibits PDE5 which can increase arousal in men and women. There is not much information on increasing quanosine except that nitric oxide dramatically increases gaunosine. Low guanidine levels causes cardiovascular disease, and obesity. Guanosine prevents intestinal inflammation. PDE5 inhibitors increases guanosine. Artichoke, horny goat weed, cinnamon, panax gensing, coleus (forskolin), mega tribulis extract, ferula hemonis, and Epimedium brevicornum inhibits PDE5 . Excess guanosine can cause the body to become too acidic. Also high levels of guanosine can cause food allergies. So this one would be best if a person works on balancing guanosine. Consuming fish, mushrooms, foods that contain umami increases guanosine. Tomato increases guanosine. Fish and eating brewers yeast or food grade yeast increases guanosine. Inosine increases guanosine.
Inosine (inosinic acid) – those with gout should not use inosine. It increases uric acid levels. This would increase the risk of kidney stones and make gout worse. Uric acid is a potent antioxidant but high levels can decrease nitric oxide levels. So if your uric acid levels are high or nitric oxide levels are low I would not increase inosine. That being said, inosine reduces oxidative stress which improves athletic performance by improving blood flow, preserving ATP and preventing high lactic acid levels in muscle. It improves the healing and growth of nerves so improves brain health. It has been found to help with Parkinson’s disease. It reduces the symptoms of amylotropic lateral sclerosis and multiple sclerosis. It prevents high glutamate levels in the brain which would prevent anxiety and autism. Inosine protects the brain from the effects of toxins. Inosine helps to prevent fatigue. Inosine has been shown to help prevent type 1 and type 2 diabetes by improving the health of pancreatic B-cells. Inosine improves overall eye health. It is produced by the body and it increases adenosine. It can also be acquired through eating brewers yeast, and organ meats. If taken in supplements not more then 500 to 2000 mg should be taken.
Written by Lee Stevenson. Sorry I am a lousy editor.
This is not medical advice I have written the for educational purposes.
At the end of this I am going to briefly explain how someone can heal and how a person’s friends and family can help with the healing of the individual. Keep in mind if you are getting allopathic treatment then this article will be bleak for you because those getting allopathic treatment the outcome usually is not good. Those who seek the treatment of a functional medicine practitioner the outlook is much much better. Allopathic medicine is limited in the testing they do because they only know how to look at the symptoms and not the cause of illness. Functional medicine looks at the cause of illness so many of the test I mention in this article most will have never heard of them. If your medical practitioner does not know what these test are or what labs they can order them from then I would seek someone else it means they do not know enough to help you heal. It is becoming clearer and clearer most of the time if you chose allopathic you chose death and if you chose functional medicine you choose life.
You can heal from this. The keys are getting inflammation down, reducing oxidative stress and addressing whatever caused the illness and correcting any health issues caused. I have written this to help clarify why certain things happen and at the end I explain that there is a way out and you can heal. Something I do not mention is mold it can cause illness if a person is subjected to high levels and they have other health issues. It can lead to them developing sepsis, post sepsis or CIRS.
I am going to try and make the distinction between sepsis and post sepsis and explain how they contribute to long term illness and even mortality. The harm caused to the body from sepsis can take years to heal if the person who is ill does not have the proper guidance and treatment. Allopathic medicine only treats the symptoms they do not treat the cause so can only throw medications at the condition which eventually causes a person to become sicker while they feel better at first. Functional medicine addresses the causes of the illness. I am also going to discuss the causes of sepsis which there are many and infection is not the only cause. Something to take note of infants are being born with sepsis. If they parent has experienced vaccine injury , come in contact with toxins especially glyphosate, used antibiotics, medication, excess stress it can induce sepsis in the infant and they can be born with sepsis even vaginal dysbiosis can cause an infant to be born with sepsis so many who are now adults have some how managed to survive post sepsis and have dealt with it most of their lives. These ones can heal but it takes much more time and patience. For example glyphosate has been found to be very high in many infants and it has been found to be very harmful especially to a developing child. Functional medical practitioners are aware of sepsis and know how to deal with and prevent it to reduce the harm and speed up recovery.
Sepsis is one of the leading causes of death in the world. Post sepis is what occurs when a person survives sepsis. In sepsis the body is fighting to stay alive. It can result from infection, emotional trauma, depression, physical trauma, drug injury, vaccine injury, eating foods high in toxins such as GMOs, farm chemicals found in most foods and toxins added to foods. Sepsis usually occurs from more then one of those thing occurring . Many infants are in a state of post sepsis from parents who have been vaccine injured or from being vaccine injured as infants. In sepsis the body is fighting to stay alive so it shuts many things down and upregulates many other things. This is keeping the person alive but causes a lot of damage in the body and causes thrombosis which causes excess blood clotting and damage to blood vessels. The mortality rate for Sepsis is very high. In sepsis the adrenals get upregulated , the body starts causing the blood to clot, systemic inflammation and excess oxidative stress occurs. If the sepsis and cause of sepsis is not addressed the person has very little chance of surviving. Sepsis causes a hormone imbalance that is unique from post sepsis. In sepsis the adrenal hormones are very high in post sepsis the adrenals have become worn out and no longer function properly. It takes a very strict protocol to help recover from sepsis and post sepsis. If a person does not address what has caused their sepsis while they are in post sepsis they can slip back onto sepsis only this time it is much more dangerous because of the organ damage and tissue damage that has already occurred throughout the body. Infants born by C-section have a dramatic increased risk of acquiring sepsis because they do not receive the microbes that protect them from the mothers vaginal fluids. Infants who are breast fed have a dramatic decreased risk of sepsis. Studies have shown the sooner a mother starts breast feeding the less the risk is of the infant getting sepsis. The microbes that protect the child can be found if a person know where to look and has an experienced functional medicine practitioner.
Sadly when a child experiences sepsis from a vaccine the medical professionals lie and instead of reporting the adverse reaction to the vaccine they brush the parents concerns off or they will lie and tell them it is proof the vaccine is working. We also cannot rule out other causes of neonatal sepsis though. These are some of the symptoms of neonatal sepsis. These are the main symptoms but not all symptoms. If a child develops sepsis from vaccine injury it is up to the parent to report it. Mot medical professional do not know how to identify vaccine injury and the ones who do will not report it.
Not feeding will or frequent vomiting.
Fever or inability to properly regulate body temperature.
Rapid breathing or long pauses in breathing.
Pale appearance or a whole body rash.
Something else that occurs, sepsis can cause gut dysbiosis and gut dysbiosis can cause sepsis. The systemic inflammation cause our gut microbial makeup to change to an inflammatory one. This leaves things that normally would not enter the body enter the body such as endotoxins, heavy metals and environmental toxins and even food particles. This is why those with sepsis and post sepsis develop, high heavy metal levels and will have oxalate issues, food intolerance and food allergies. This is a cycle that becomes difficult to break because this also contribute to the systemic inflammation, immune dysfunction,and oxidative stress. This is why it is very very important to heal the gut when dealing with sepsis and post sepsis. Gut dysbiosis on it’s own can cause organ damage and failure and has been linked to diabetes, mental disorders and heart disease. When a person develops sepsis they also become more prone to infection increasing their risk of dying from sepsis or post sepsis. It is very important to replace the microbes lost, reduce inflammation and balance the immune system.
You can survive sepsis and post sepsis. It takes someone very knowledgeable in functional medicine. It takes very specific supplements and nutrients unique to each person. There is no one size fits all. If a person has post sepsis and has not addressed what caused their sepsis they could develop sepsis again and each time their risk of mortality increases because many organs are already damaged and struggling to function. When a person has post sepsis things such as the adrenal and many other hormones are low. I will not get into detail because it can get very complex.
When a person experiences Sepsis DAMPs, MAMPs, and PAMPs are released. These are danger signals that stimulate the immune system, systemic inflammation, and oxidative stress all these things contribute to damage in the body but also contribute to keeping a person alive by preventing the toxins, depression, infection or any other causative agents from killing the person. It is the bodies last ditch effort to survive. So to survive sepsis you need to address the causes. Also to try and prevent post sepsis the inflammation, oxidative stress, organ damage, metabolic and gene issues caused need addressed. A person who has survived go into a state of post sepsis. Usually the oxidative stress and systemic inflammation is still there but they have metabolic issues, organ issues, endocrine issues, and immune dis-regulation have to be addressed. If these things are not addressed chronic illness will start to occur and they will develop autoimmune diseases, digestive issues. Brain swelling occurs and needs addressed. The organ damage needs addressed. If the post sepsis is not corrected organ failure will occur and a person will start to develop things such as liver disease and kidney disease, interstitial cystitis and many many more illnesses. When it has reached the stage of causing organ damage it takes much much longer to correct. Notice inflammation is one of the key factors in causing the chronic illness. Reducing inflammation is key to healing.
Most allopathic medical professionals do not know how to identify or deal with sepsis but functional medicine practitioners have been trained to identify and address it. It is very important to distinguish between sepsis and post sepsis. What is good for treating sepsis may home someone with post sepsis. There are those who still have the issues that caused their sepsis so they will alternate between bouts of sepsis and bouts of post sepsis. Those are the most difficult to heal because with those one the little things are very very important. Ones who can still have a tendency to experience sepsis get set back very very easily. Things that would normally be beneficial like social interaction can really take it’s tolls on those who are still going back and forth between experiencing sepsis and post sepsis. When I was very ill it was surprised how even positive social interaction would set me back for days. The brain is so focused on healing the body and dealing with the pain and keeping track of healing and what needs to be done to heal that anything that takes more thought can set us back. I remember if I interacted on Facebook too much when I was very very ill it would really set me back and often times it was positive interactions, my Facebook friends would be encouraging me and teaching me. But combine the chronic illness , with the normal stresses of daily life and it gets overwhelming. This can increase the blood clotting and tax the adrenals which dramatically sets our health back. It also increases brain inflammation. So when in a state of sepsis or post sepsis we have to learn to listen to our bodies and our minds. It can be difficult because sometimes it is necessary to isolate ones self to let their brain and body recover. Little things are very very important like maintaining glucose and insulin levels, making sure we support our adrenals. Even though we may want to be sociable if our minds or our body is telling us not to do it then we need to find a way to listen to our bodies within reason. We do have certain family responsibilities but We also need to try our best to get our family to understand the harm of social interactions and others things may be causing us. These things are usually healing to the body when we are well but when in a state of sepsis or post sepsis the body is in survival mode so nothing is as it should be. Those experiencing sepsis or post sepsis often times look healthy, and will pretend to be healthy which I did often so they are responsible for some of the lack of understanding people have towards those who are chronically ill. These can be prevented and corrected with the correct guidance from someone knowledgeable in how to deal with these things.
Now I will cover the many ways that sepsis and post sepsis kills. They kill by causing damage to the organs, this is why those with sepsis and post sepsis die from organ failure, brain damage, but the most common cause of death during sepsis and post sepsis is heart failure. The inflammation and oxidative stress damages the organs including the heart and brain. It also causes excess blood clotting and excess blood vessel damage which often times leads to heart failure. Another way that sepsis and post sepsis causes heart failure is through the adrenal dysfunction. The limbic system regulates our blood pressure and heart rate. A healthy adrenal system is required for this. This is where the real harm comes in because adrenal dysfunction also causes excess blood clotting and blood vessels can constrict, now add to the fact the inflammation and oxidative stress is interfering with the limbic system and adrenals to interact with each other to properly regulate the cardiovascular system and a person because prone to heart failure or stroke. There are many other ways that sepsis and post sepsis can cause heart failure to numerous to continue but these are the most common causes. I am stating this to let people know the importance of not ignoring these things. They need addressed and corrected.
Because the body experiences oxygen deprivation from the restricted blood flow throughout body causes organ damage, damage to the brain and neurological damage. The neurological damage in itself can cause death. Now ad to the fact that pain has been shown to cause things to occur in the body that can result in death. Mitochondrial function get upregulated during sepsis and down regulated and even inhibited during post sepsis. So if we do things that would increase certain mitochondrial processes during sepsis it could increase the persons mortality. For example when a person is in a state of sepsis increasing ATP levels increases mortality but when in a state of post sepsis increasing ATP can speed up healing. In post sepsis usually mitochondria function is inhibited so increasing it can speed up recovery but in full on sepsis increasing certain mitochondrial function can increase mortality. I will try to cover the best I can how to distinguish between the two though some things do overlap in sepsis and post sepsis for example often times oxidative stress and systemic inflammation levels are still high in both.
Now I will try my best to describe the symptoms of sepsis and test that can be used to detect when someone has sepsis.
Fast heart rate or an irregular heart beat
Temperature dis-regulation some may have a fever some may be hypothermic.
Warm or clammy skin or excessive sweating.
Mental confusion , feeling disoriented, or disassociation
Rapid breathing or shortness of breath and at times it may be difficult to take a breath.
Difficulty waking up.
Skin rash, skin burning or severe itching.
If severe enough seizures.
Some test that can be used to detect if a person has sepsis.
Excessively high or low glucose or insulin levels.
Back pain which is caused by a variety of issues.
Irregular heart beat which can cause dizziness when walking or standing.
Sudden sharp or burning pain in the chest.
Difficulty breathing especially when lying down.
Anciety, fear, flash backs, even paranoia from the increased brain inflammation. This can also cause depression and suicidal thoughts.
Ok test that can be used to determine if someone has sepsis . Now some of these test also overlap with post sepsis.
Vassopressin levels it becomes impaired during sepsis.
Glucose and insulin levels
A complete thyroid test even testing for reverse T3. Usually reverse T3 is low and T4 levels are high. Thyroid hormone levels usually become decreased.
Testing cortisol levels . Cortisol is usually high.
During sepsis Growth hormone levels are usually high.
Often times white blood cell count is high in sepsis.
Low red blood cell count or high red blood cell count which often times gets mistaken for leukemia.
Liver function should be tested because it becomes impaired during sepsis. Bilirubin and creatine should be tested.
Lactic acid levels usually become high during sepsis.
Inflammatory cytokines such as C-reactive, IL-3, IL-6, IL-8, IL-10, MCP-1, MMP-9, IL-13 and TNF-a.
Troponin, natriutetic peptides and myoglobin to check for myocardial dysfunction.
Arterial blood gases to test pulmonary function.
Prothrombin time and partial thromboplastin time, platelet count when low it indicates excess blood clotting. D-dimer can also indicate if blood is clotting excessively.
The type of sepsis is important to determine it is from infection or to rule out infection a test for endotoxins can be done. It is non specific but it will indicate if an infection is present.
If procalcitonin is high it can indicate there is a bacteria infection present.
IGF-1 is low during sepsis.
Catecholamine levels become high during sepsis. (dopamine, norepinephrine, epinephrine)
Glutamine levels become low but increase in the brain because it’s uptake into the cells becomes inhibited. This can cause glutamate toxicity in the brain. Increasing glutamate levels during sepsis increases risk of mortality.
Copeptin is usually high in sepsis which makes it difficult to urinate.
Leptin levels are usually high during sepsis.
Luteinizing hormone releasing hormone is usually high during sepsis which increases B-endorphin and GABA.
Ok now lets cover Post Sepsis . Many of the symptoms of sepsis and post sepsis overlap for example usually the systemic inflammation and oxidative stress levels remain high. So the organ damage, brain inflammation and immune dysfunction remain but the symptoms will change because often times the organ damage causes hormone changes that are different in sepsis. For example the adrenals, liver and kidney function has because lower so those hormones and enzymes will be different then that found in sepsis. Mitochondrial respiration and other mitochondrial functions have become inhibited in post sepsis. In sepsis it usually becomes upregulated so the causes of oxidative stress between sepsis and post sepsis are different.
Some symptoms that may be found in post sepsis.
Difficulty sleeping or difficulty staying asleep.
Sever muscle and joint pain. Poor muscle function, muscles will be tight and difficult to move.
Swelling in limbs
Susceptibility to repeat infections.
skin rashes or burning skin
many of the psychological symptoms carry over to post sepsis such as anxiety attack, memory flash backs, nightmares or strange dreams that make no sense, difficulty concentrating, memory loss
Most medical professionals do not even acknowledge sepsis. They send patients home and either they are not concerned or lack the knowledge to be able to identify when they have caused sepsis or they are trying to hide their error. Studies have shown that most who have had sepsis get sent home and have no farther support or resources which increases their mortality. Now add to this , the fact that those with sepsis appear to be healthy so they get ostracized and criticized by family. They do not get the support they need and often time family adds burdens to them that not only hinder their healing but because of the stress, depression and physical demands it can send them back into sepsis this is why those who have survived sepsis have a 40% mortality rate. They lack the support and resources needed for them to heal. When a person is suffering from sepsis any emotion even positive can put a physical demand on the body because their body and brain are in survival mode. Yet they say that those who have post sepsis have lost their minds and are isolating themselves, or they are neglecting family when they are actually trying to survive. Those with post sepsis are on a teeter totter. They can quickly develop sepsis again and each time it takes longer to recover. Little things add up and can help a person to get over the hill and start to recover but very few have the support they need to focus on those little things. I cannot get into details when I say little things because the list is long but one of them is when a person is showing memory loss or being irritable they are struggling and need help with some of the normal everyday burdens that are usually easy for others to do. They become mountains for someone suffering from post sepsis syndrome.
It would take me a very long time to show what happens and why with post sepsis. The mitochondria is the little factories of the body which are involved in almost everything in the body. In post sepsis the mitochondria shrinks and molecules can not longer be transferred into and out of the mitochondria. It slows the bodies processes down. In order to get the mitochondria functioning again. The inflammation, oxidative stress, metabolic issues and many other things have to be corrected. It takes very specific nutrients for the person and a lot of self discipline. A person can recover from post sepsis but it takes time persistence and a lot of learning. There are many things that occur in sepsis and it takes very specific nutrients to get things functioning correctly again. For example often times the pituitary, adrenals, thyroids and hypothalamus become damaged. It takes time and very specific nutrients and protocols to promote their healing. This causes many hormones to get out of balance like estrogen, progesterone, testosterone, adrenal hormones, many hormones needed for proper brain function. The gut becomes damage and the microbes in the gut become out of balance and need corrected.
If these things are not corrected a person will develop cardiovascular disease, diabetes, cancer, autoimmunity and many other chronic illnesses. There are not test for post sespsis but test for things such as CIRS also known as SIRS can help to determine what needs addressed.
Hormone test, complete thyroid test and adrenal hormone test along with testing for CIRS can help to determine if a person has post sepsis. It can persist for years especially if the health problems that contributed to it are not addressed. A person can recover if they are diligent.
These are test for CIRS
Vassoactive intestinal peptide – this is usually low in post sepsis.
Transforming Growth Factor Beta 1 (TGF-b1) usually increased in post sepsis and CIRS. It is involved in cell division and cell death.
Melanocyte stimulating hormone (MSH) controls the pigment of the skin, regulates how much cytokines can be produced. Usually low in post sepsis and CIRS. If it is low the production of inflammatory cytokines cannot be shut down.
C4a – when levels are high it indicates systemic inflammation.
Adrenocoricotropic hormone (ACTG) regulates cortisol levels. It is usually low in post sepsis and CIRS.
Anti-gliaden antibodies (AGH, IgE, IgA) – triggered in response to mold toxins, inflammation and gluten sensitivity. It can also indicate gut inflammation.
Cortisol usually low in post sepsis and CIRS.
Vascular Endothelial Growth Factor (VEGF) – Stimulates blood vessel formation. Is usually low in post sepsis and CIRS.
Leptin – helps regulate fat storage in the body. Excess inflammation causes leptin resistance which can increase levels of leptin. This can cause excess weight gain and diabetes.
Anti-cardiolipin antibodies (ACLA) , IgA, IgG, IgM – high in autoimmune disease. Indicates high levels of inflammation. If these are high it indicates the body is attacking healthy tissue.
Antidiuretic hormone – it is responsible for regulation of the balance of water in your body, blood pressure, and concentration of urine being produced in the kidney. Reduced levels of ADH couldn indicate dehydration or excess urinating.
Little things really mean a lot when it comes to healing. Reducing stress, or try to deal with stress in a less negative way. Family and friends can help by reducing stress as much as possible. When someone has CIRS or post sepsis it is like being on a teeter totter. It does not take much to set their health back for weeks. What little progress they have made can easily be set back and they have to start climbing the figurative ladder over again.
There are things that can indicate someone with CIRS or post sepsis is starting to back slide with their health or need to take a rest. If they start getting irritable or absent minded, confused or disoriented it means they need to rest. The adrenals and other organs in the body have become damaged and take a very long time to heal. Even positive social interactions take a lot when it comes to adrenals and physical energy. When someone who is interacting socially either in life or online and you see those things start to occur it means they need some alone time and need time to let their adrenals and energy levels recover. If they keep pushing through it they will get set back and be in a very bad way for a while. Much of the progress they made will be lost.
It is very important to reduce inflammation and oxidative stress. The body requires higher amounts of certain nutrients so it is very important to get the proper nutrients the body needs. There are very specific supplements that can help the body to heal. Not all functional medicine practitioners are the same. So find one who has a proven track record of success. Do not skip meals. Fasting can be injuries when a person is dealing with CIRS or post sespsis and it can set the persons health back. Taking the wrong supplements can cause harm also so they need to be will researched and make certain they would be what is best. If in doubt don’t.
A person may recover enough to function but if the health issues are not addressed they will be prone to many types of illnesses, from allergies, food intolerance, interstitial cystitis, inflammatory bowel disease, diabetes, autoimmunity and even cancer. Cardiovascular disease is the number one cause of death in those with post sepsis and CIRS. It is very important to get the hormone levels straightened out, reduce the excess blood clotting, reduce the inflammation and oxidative stress. All these alone contribute to hear damage, strokes , neurological damage that can cause the heart to fail, imbalances in the minerals in the body which can cause the heart to beat irregular. Stress, to much emotional interactions, over doing it physically, and many other things can increase the risk of those things occurring. When you are healing it is very important to realize you have limits even on days you feel good and set those limit and do not pass them even if you feel well. They add up and will catch up with you and can set you back.
It is good to do things like listen to music, color in coloring books, do puzzles, do word games, read some jokes laughing is very healing. Going in nature has been found to promote healing. There are many things a person and their family can do that can promote healing. Little things mean a lot. They add up and can help someone get over the hill so they can fully recover.
Often times because those with CIRS and post sepsis do not look ill and we can put on a good front in pretending we are well they will not realize how ill the person really is. That is why if you see the person tripping a lot, getting disoriented, absent minded or irritable. They may start sitting down a lot . Their breathing may speed up. It means they need rest and most likely need to be alone for a while so their adrenal hormones can also recover. Sometimes those who are chronically ill just want to be normal again. I did it to myself often but I was fortunate and had two friends that were aware of what I was doing to myself and would make me slow down and rest and take time to myself to recover. So the person who is ill may need others to watch out for them. Those who are ill try so hard to be normal again or just to function that they will often times push themselves too much and end up setting themselves back so much it may take days or weeks to recover.
When a person has post sepsis or CIRS their immune system is barely functioning. When I was very ill people would come near me with colds or sore throats. I easily picked these infections up even when I kept my distance. This would set me back for weeks. Sometimes I would even end up bedridden for days. Even when a person who is ill has restored immune function the damage the infection causes to the persons body sets the back physically and makes them lose a lot of the work they have done to heal.
I personally struggled eating properly because most food especially GMOs are very damaging to the body. If I would eat them I would become very very ill and it would set me back. Most people do not understand this. I would have them go shopping and put very specific brands on the list but if they could not find those brands they would replace them with GMOs. I could not eat them. If I went shopping myself I would be too exhausted to cook so often times would not eat for a day which would set me back health wise. Eating three meals a day became a major struggle for me when I was ill. For some who experience type 1 diabetes type symptoms they may have to eat a bunch of small meal a day to keep their energy levels up so they do not back slide.
The main thing is working on getting the mitochondria repaired first. Then work on the immune system. If you repair the immune system before the mitochondria is functioning adequately it can make the person very ill. They need the mitochondria to be functioning to launch a proper immune response. One if the most important things about healing is addressing the excess blood clotting and neurological damage. These cause organ and brain damage that will continue until proper blood flow is restored and neurological function is corrected.
I did a blog post that explains you can heal and at the end of it , I explain how to find someone who can help you learn to heal. Allopathic medicine only treats the symptoms and if you compare the research from those treated with allopathic medicine the outcome is usually not good it usually end in death. If you look at the outcome from those who have been treated with functional medicine they have recovered and lived a productive life. Allopathic medicine only treats the symptoms, functional medicine treats the cause. I explain in much better detail in the article in this link. This link also show there are labs that will let your order test online. https://iamajuicer.wordpress.com/2021/05/28/how-to-get-off-the-medical-hamster-wheel/
Health problems caused by sepsis are long lasting unless an experienced functional practitioner guide the healing.
Medications, GMOs, farm chemcials espeically glyphosate can alter the microbiome causing high MAMPs levels which leads to thrombosis and death if those things are not corrected. Altered gut microbiome can cause high levels of MAMPs.
Sterile trauma induced sepsis is sepsis induced by physical or emotional trauma. There are not specific markers to distinguish which a person is dealing with this is why it is important to talk to the person and get to know a little about their background and consider if they had any surgeries.
Modern medicine only treats the symptoms and not the cause of illness. There is no profit in treating the cause. This keeps people on a medical hamster wheel believing they cannot heal. Often times modern medicine is the very cause of a person’s illness. When you hear things like the illness is genetic, or they do not know the cause of your illness , it is most likely they caused the illness. I am going to explain the options available including some supplements that may help a person heal.
The united states has some of the highest rates of chronic illness, cancer , diabetes and autoimmunity in the world. Studies have shown up to 80% of the population in the U.S. is taking some form of medication. Those medications require other medications to deal with the side effects of the first medication. Medications do not treat the cause of illness they only treat the symptoms. The U.S. has the highest vaccine rates in the world , vaccines have proven to be very harmful to the body. Diseases such as cancer used to be rare now infants are being born with cancer. It is clear modern medicine gets people on medical hamster wheels.
Medical error is the third leading cause of death. Now combine that with the fact that almost no adverse reactions to medication get reported and only 1% of vaccine adverse reactions get reported. So the number of deaths caused by modern medicine is most likely much higher. Vaccines have caused thousands of documented deaths and that is only the ones that have been documented. It has become clear modern medicine is not making society healthy. Fortunately there is a form of medicine that can help a person to heal and not just treat the symptoms.
Functional medicine treats the cause so instead of being on medications all your life you address what is causing the illness and correct it. I did a blog post about it with information on how to find a functional medicine practitioner. Functional medicine practitioners are more aware of the flawed genetics science and has not been blinded by much of the flawed science produced by the medical industry and pharmaceutical industry. I have provided links at the bottom of the page to resources to help one learn more about functional medicine and to also guide their decisions on how they may be able to approach their healing.
This is not medical advice this is for educational purposes. Do not use this information yourself , find an experienced and reputable functional medicine practitioner. I am going to explain some things to demonstrate the many things that we have that can help a person to heal with the proper guidance.
Recently science has learned that it is not our genes that determine if we get ill or not but it is our exposome (internal and external environment) . The toxins we come in contact with externally effect our health, toxins in our foods especially GMO foods and foods with high farm chemical levels. Stress , vaccines, and trauma can effect our health. Because of over farming and chemicals like glyphosate being spray our food has become deficient in nutrient. The farm chemicals being sprayed are killing the microbes in the soil that help plants absorb nutrients, this makes our food even more deficient in nutrients. Many illnesses including infectious disease can be linked to nutrient deficiencies. For example those who where deficient in things such as vitamin D, zinc and selenium were much more likely to become ill from Covid. Most infections can belinked to a nutrient deficiency. Even many types of infection can be linked to chronic illness.
Science has come to discover that our microbiota throughout our body modulate our genes and metabolic pathways more then our own bodies do. This is why with a knowledgeable person who knows how to use nutrients, plants, microbes and other natural resources can help guide someone to heal from many supposed non curable illnesses such as autoimmunity or diabetes.
There are test that can narrow down the cause by showing the symptoms or even lead directly to the cause. I will now list some test that can be used to help narrow down and identify the cause of illness. If your medical practitioner does not know what these test are then I would recommend you find one that does.
OATS test – organic acids test. Organic acids are excreted in the urine and are products of metabolism. OATS test can help to determine toxins in the body, indicate nutrient deficiencies, and can even identify certain types of infection.
GI Map test – Test microbial balance in the body or microbial deficiencies. Microbial imbalance can cause excess inflammation, gout, arthritis, cardiovascular disease, diabetes and could make someone prone to infection and autoimmune disease. GI Map test can also show hormone imblances and pinpoint digestive issues.
Testing for oxidative stress – Excess oxidative stress can cause the same health issues as inflammation and is very damaging to the body. It can lead to organ and brain damage. Testing for oxidative stress test levels of antioxidant enzymes and for reactive oxygen species or free radicals. The biomarkers that are checked is protective enzymes such as glutathione, total antioxidant capacity, cysteine/ cysteine sulfate ratio, glutathione peroxidase, super oxide dismutase. It looks at triglyceride levels.
Dutch test – hormones effect our sleep, metabolism, heart, cognitive abilities, blood sugar levels, mood, for women it can effect their estrous cycle. Dutch test test cortisol, cortisone, estradiol, estrone, progesterone, testosterone, DHEA, melatonin levels. It also test O-OhdG levels which is a marker of oxidative stress.
Comprehensive Blood anyalysis – this checks nutrient levels, c reactive protein levels which is an inflammatory cytokine, homocysteine , full thyroid panel, antibodies test, blood glucose and insulin levels, read blood cells and iron status, urinary tract health, liver and kidney health, parathyroid status.
Testing for CIRS – anyone who is chronically ill, has autoimmunity , diabetes or heart disease most likely has CIRS. CIRS is chronic inflammatory response syndrome. The government calls it Systemic inflammatory response syndrome (SIRS). Because functional medicine diagnoses the whole body they are much better at identifying the cause. Allopathic medicine only identifies the symptoms and can only treat the symptoms of the illness. By identifying the cause and addressing it you can recover instead of being ill all your life.
Some things you may experience that could indicate you have CIRS. Brain fog or confusion, feeling dissociated, difficulty learning and remembering things and many other mental issues. Skin sensitivity , skin burning or tingling. Red eyes , frequent sweats, ice pick like pain, numbness in various areas of the body, coughing, congested nose, frequent tearing, metallic taste in mouth, joint pain or stiffness, muscle pain or stiffness, appetite swings, difficulty regulating body temperature, and vertigo. There are many more symptoms but these are some of the most common.
Next a person would need to be questioned to identify any possible infections or exposures to mold. Then a visual contrast sensitivity test is done. These can usually be done online for about $10 and the results would need to be shared with your practitioner. Then test need to be run.
Human leukocyte Antigen genetic test which I do not agree with because this blames the genes for not being able to detox mold toxins and science has shown most genetics science is severely flawed.
MARCoNS which is a multidrug resistant strain of staphylococcus that is usually acquired in hospitals.
Vasoactive intestinal peptide – it is involved in the regulation of the cardiovascular system, digestion, glygenolysis, pituitary function, and vaginal lubrication.
Melanocyte stimulating hormone – prduced in the pituitary and hypothalamus. It is also produced in the skin when exposed to ultraviolet rays. It reduces inflammation. It also regulates aldosterone.
Transforming Growth Factor Beta 1 (TGF-B1) – Involved in tissue regeneration, immune regulation, involved in the suppression of cancer.
C4a -complement 4a test for autoimmunity and other health problems. High levels usual indicates mold infection or exposure. Some infections will also increase C4a.
Antigliadin (AGA/IgG) – this is used to test for gastrointestinal issues especially celiac.
Adrenocortitropic hormone (ACTH) cortisol – the pituitary regulates the production of cortisol. It measures adrenal and pituitary health. They are involved in the production of steroid hormones.
Vascular endothelial growth factor (VEGF) this plays a role in wound healing, regulating blood pressure, ovulation, menstrual cycle, and pregnancy. Over expression has been link to arthritis, macular degeneration, diabetic retinopathy and many types of cancer.
Antidiuretic hormone (ADH/osmolity) – regulates water levels in the body. A deficiency causes excess thirst and can cause excess urination. Excess causes headache, nausea, and vomiting.
Matrix metallopeptide 9 (MM9) – also known as gelatinase elevated levels have been linked to arthritis, autoimmunity, cardiovascular disease and ischemia.
Since the science is discovering that our microbiome modulate our genes and metabolic pathways more then our bodies do they are developing new test to get better understanding of a persons health status and what microbes they may need to increase or reduce to achieve and maintain health. These test are not available yet but seem to be proving to be very effective.
One test is Microbe (MESA)- set enrichment analysis test. It measures or test host microbiome interactions.
These are just a few things that a functional medicine practitioner may use to help someone heal.
Now I will discuss some of the microbes available and how they effect our bodies:
Lactobacillus DR7 Reduces inflammation, improves cognition and memory. It upregulates tryptophan-serotonin pathways and reduces tryptophan -kyneurine pathway. This increase the hormones in the brain that helps us to deal with stress and helps promote happiness.
Many microbes help to prevent infection , for example Lactobacillus Rhamnosus GG and Bifidobacterium Lactis help prevent Picornavirus infection and the flu.
Most Bifidobacteria reduces risk of nasal infection. Bofidiobacteria help prevent virus infection and some Lactobacillus do especially Lactobacillus acidophilus. Many who got very ill with Covid were found to be deficient in Bifidobacteria.
Lactobacillus Rhamnosus has been found to help prevent the flu.
Lactobacillus Slivarius, Lactobacillus Brevis, and Lactobacillus planatarum help prevent Herpes simplex 2 infections.
Those who had these microbes were found to be more resistant to viral infection including HIV and women who contained these were found to be resistant to vaginal infection.
Some species of microbes reduces the risk of cancer such as some species of Bifidobacteria, butyrate producing bacteria such as Clostridium Spp. Lactobacillus crispatus helps prevent cervical cancer.
Some microbes prevent dermatitus such as Lactobacillus rhamnosus, Lactobacillus casei, and Lactobacillus Fermentum.
Some can help reduce inflammatory bowel pain such as Bifidobacterium breve, and Bifidobacterium longhum.
Abdominal distention is when air or fluid accumulate in the abdomen causing it’s expansion (bloating), it can also cause flatulence. These microbes can help reduce the symptoms. Bifidobacterium breve, Bifidobacterium infantis, Lactobacillus casei, Lactobacillus planatarum.
Short chain fatty acid producing microbes have been found to help reduce this. Lactobacillus acidophilus have been found to reduce high LDL levels.
The list of microbes goes on and on. Some have been found to prevent obesity, diabetes, heart disease, and others have been found to prevent autoimmunity. So far there are around 1500 microbes known to be a part of the microbiota in humans.
Now I will discuss nutrients.
Magnesium helps prevent high blood pressure, prevents depression, improves sleep quality. It is needed for most metabolic processes in the body. Because of the above mentioned things many are deficient in magnesium. Magnesium is needed for proper immune function. It is needed for proper mental health, and metabolic health. If deficient a person can develop restless leg syndrome, sleeplessness, NMDA receptor over activation so has been found to be low in many who have autism. If deficient in magnesium it can damage the cardiovascular system. Magnesium prevents oxalate build up in the body. Magnesium prevents excess blood clotting. Magnesium deficiency can cause glaucoma. Magnesium increases our tolerance for stress. Low magnesium and high aluminum levels can cause Parkinson’s .
Zinc improves function of the immune system, it is needed for many metabolic functions, and it prevents depression.
Polyunsaturated fatty acids such as cod liver oil, coconut oil, flax seed oil, and olive oil help prevent obesity, diabetes, inflammatory diseases and improves immune function.
Vitamin B12 which many are deficient in now days protects the nerves and brain, it prevents homocysteinuria and prevents mental issues.
SAMe has been found to dramatically reduce the symptoms of arthritis.
Nitric oxide is needed for proper immune function, reduces oxidative stress, needed to prevent inflammation in the gut, prevents cavities, helps to prevent cardiovascular disease. Our bacteria in our mouths convert the nitrites and nitrates in our food to nitric oxide. NO also prevents osteoporosis and increases exercise endurance. Many are deficient in nitric oxide because of the over consumption of process foods. Leafy greens and beet root are high in nitrates. Nitric oxide is also needed to maintain proper glucose and insulin levels.
Niacin is needed to fuel oxidation , especially of fatty acids. It is need to produce ATP which is the energy needed by almost all cells in the body. It is also needed for gluconiogenesis, ketogenesis, needed for proper function of the pentose phosphate pathway, it is needed for producing heme, steroid hormones, and detoxing free radicals. Low niacin levels results in DNA damage. Niacin stimulates the longevity genes, prevents heart disease and can reverse some signs of aging. It protects brain cells and helps to prevent glaucoma.
Vitamin B6 has been found to be deficient in many now days. It is needed by almost every process in the body. It prevent amyloid B formation which cause Alzheimers and organ damage. It prevents excess inflammation. It is neuro protective so protects the nerves and brain.
Vitamin D is another nutrient many are deficient in now days. It reduce the risk of cancer, decreases mortality , It is needed in many metabolic processes especially those involved in digestion. It helps prevent viral and bacteria infection. If vitamin D is low a person will experience poor bone health and will develop cavities.
The list of nutrients goes on and on and how the effect the body. Some nutrient deficiencies can cause autoimmune diseases such as lupus , or eczema. Carbohydrate deficiency can cause autoimmunity.
Now let discus supplements that have been shown to help when someone is ill.
Boswellia (frankinsense) reduces inflammation and helps restore proper immune function.
Tumeric reduces inflammation, reduces risk of autoimmunity, heart disease, diabetes and cancer.
Panax gensing has been shown to reduce the symptoms of type 2 diabetes.
N-acetylcysteine (NAC) inflammation and oxidative stress are the main conditions that occur in the body that causes chronic illness. NAC reduces inflammation and oxidative stress. It has been shown to help fight many types of cancer. It prevents excess cell death and neurological damage. I help to prevent mitochondrial dysfunction. Help reduce symptoms of withdrawal from drug addcition. Protects the brain and helps prevent mental disorders. Helps with COPD. It has been shown to help with NAFLD. It reduces insulin resistance and symptoms of PCOS. It reduces colon polyps and increases the beneficial effects of Nitric Oxide.
Ashwangha improves cellular energy levels, it improves resistance to mental and physical stress, very potent antioxidant and anti-inflammatory. It increases bone marrow production. It increases hemoglobin, and increases thyroid hormones.
Lemon Balm reduces pain, has potent antispasmodic effects. Effective at fighting many types of viruses including herpes simplex 2 and Covid. Reduce the severity and bleeding during the estrous cycle. Reduces anxiety and improves sleep quality. Potent anti-inflammatory. It improves blood glucose levels and HbA1c levels. It inhibits HIV.
Aloe Vera helps to reduce inflammation in the gut and reduces ulcerative colitis, It helps to reduce mast cell degranulation preventing high histamines and MCAS, it prevents excess histamine release, helps maintain normal glucose levels, high in minerals and antioxidants. It improves fat and carbohydrate metabolism. It helps reduce the symptoms of IC and has been shown to help prevent cancer. It has antibacterial properties against Staphylococcus Aureus, E Coli, Pseudomonas derugilosa, Salmonella typhi, streptococcus pyrogenes and most other types of Salmonellla.
Melatonin one of the most potent anti-inflammatory and antioxidants. Has been shown to reduce symptoms of some forms of autism. It improves sleep quality and reduces the symptoms of Alzheimers, improves mental health and glycemic control.
Stinging Nettles reduces arthritis pain, it is an aromatase inhibitor which reduces androgen levels. This would reduce the incidence of certain types of cancer especially prostate cancer. It reduces prostate swelling. It improves urinary health. It reduces gut inflammation. Helps to normalize glucose and insulin levels.
Querciten hel;ps fight viral infection. It inhibits tyrosine kinase which prevents many types of cancer. Low dose it is an antioxidant and in high dose it is an oxidant. It helps to prevent estrogen dominance. It stimulates insulin secretion and protects pancreatic B cells. It acctivates NRF2 the master regulator of the antioxidant system. It inhibits the release of histamine. Querciten helps to revers cognitive decline and has been shown to improve symptoms of Alzheimers. It extends lifespan. Querciten increases exercise endurance and speeds up recovery time. It reduces fat build up in the liver. Querciten prevents obesity. It prevents cataract formation. It inhibits glycosylation of hemoglobin proteins. It decreases plasma glucose levels and increases pancreatic islet cells. It improves liver and pancreatic function.
L-citruline reduces symptoms of asthma, and helps prevent cardiovascular disease. It improves muscle endurance and performance.
Japanese honeysuckle found to be one of the most effective things against covid. It reduces fever and protect the body from the effects of endotoxins. It fights many types of infections including mycoplasma. It stimulates cardiovascular healing and improves cardiovascular health. It has been found to protect the liver from injury. It reduces inflammation in the gut and stimulates healing in the gut. Honeysuckle normalizes glucose and insulin levels.
Oxeye daisy speeds up wound healing including the healing of broken bones. Potent anti-inflammatory effects. Has very potent antimicrobial properties. It reduces anxiety, and pain. It prevents many types of cancer. It has potent antioxidant properties. It reduces the symptoms of Alzheimers. \
Grape seed extract prevents insulin resistance. Increases B-oxidation which prevents weight gain and increases cellular energy. Increases expression of FXR which can increase longevity. It helps restore balance to the microbiome. It protects the genes that regulate our internal clock(circadian rhythm). It improves gut and cardiovascular health. It improves endurance and strength. Grape seed extract improves bone health. It helps prevent fibrosis in the body which can damage organs. It prevents oxidative stress. It neuro protective so protects the brain. It reduces the symptoms of menopause.
Not sure of the accuracy of these sites but they have a remedy finder which will list herbs that help with certain symptoms.
Many illnesses are set off by nutrient deficiencies. Most in the industrialized world are deficient in nutrients because of over farming and the farm chemicals used chelate nutrients from the soil and they also kill the microbes that help the plants absorb nutrients. This is driving obesity because in order to get the nutrients needed many have to consume larger proportions of food. The government had to start requiring they fortify food with nutrients because of this. But some of the nutrients are man made and toxic to the body. One of them is folic acid which is toxic to the body and has been linked to dementia and cancer. They add folic acid to everything and it has been found to be in high levels in children who have autism. Folate is natural and does not build up in the body and cause damage.
If you have read article this you have taken the first steps to getting off the medical hamster wheel and learning how to truly heal and break free of the medical hamster wheel of modern medicine and take your health and the health of your family into your own hands. It is never good to entrust something valuable such as your health to the very ones who would profit from a person being ill.
Ordering your own test. Some will leave you order test without a doctor. You can order many test online and some companies use local clinics and labs to collect and test the samples. Some test do not require you go to a clinic or lab but can send the tools for sample collection to your home and they can be mailed in. There may better better and cheaper options the links I provide are to demonstrate you can order test and even have them interpreted without having a doctor do it for you.
This is not medical advice. If you are ill please find an experienced functional medicine practitioner. I am putting this here to give people an idea of what a base protocol to help start their healing will look like
Inflammation and oxidative stress.
P5P (pyridoxal 5-posphate)
Pine bark extract
CoQ10 this one a person has to ease into because it does detox cells and a person can get ill at first when taking it.
Grape seed extract.
Alternate the type of Omega threes you consume I have found alternating them to be more effective. I alternate between flax seed oil, avocado oil, coconut oil, and fish oil. Make sure the fish oil is fresh, contains lemon to preserve freshness and store it in the refrigerator.
Melatonin, if you react to melatonin it means your vitamin D levels are low
Vitamin D3 do not take over 500 IU
Magnesium I usually alternate the types I take. Magnesium citrate and magnesium chloride but if you have depreassion magnesium tuarate may help.
Maganese and molybdenum three times a week.
Zinc picolinate but do not take high dose.
If you have high ammonia
jerusalem artichoke root
TMG plant based do not get trymethylglycine HCL that is man made. Get Trymethylglycine from plants based.
This along with the base protocol
If you have infection
Butyrate producers like Clostridium butyrica
A probiotic with a variety of bifidobacteria.
Now Probiotic 10
Lactobacillus acidophilus, lactobacillus heliviticus, lactobacillus Casei shiroto
If you have IC or excess blood clotting or numbness in hands or feet.
Grape seed extract
If you are gaining weight it indicates inhibite B oxidation. You need to increase Type 1 muscle and work on restoring mitochondrial respiration. Or if you are experiencing tight or fatigued muscles.
Eat foods high in B vitamins like mushrooms.
Increase nitrate by eating foods such as leafy greens and beets.
Increase vitamin C
If you have malabsorption you may have to use sublingual supplements until your gut heals or take megatribulus extract which increase absorption of nutrients it is consumed with.
Mucilage like kudzu root, marshmallow root or maca root
Devron bismuth but do not take too long or too often. High levels of bismuth can inhibit mitochondrial respiration.
If possible drink bone broth once in a while it give the gut the nutrients it needs to heal.
Also take a complete plant based digestive enzyme complex when you eat.
This is not medical advice I am posting this for educational and informational purposes.
There are many things that can cause pain. It is usually a synergistic effect of things that have built up and caused high inflammatory cytokines, mast cell activation syndrome, high substance P levels, even metabolic issues can cause pain. I have posted on those things and to reduce pain and start healing they must be addressed. I have much more detailed notes on reducing pain but figure this would be a good start.
Many pain killers have been linked to chronic illness , for example tylenol has been linked to liver disease along with many pharmaceuticals for pain. Opoiods have been shown to increase inflammation and add to pain. Even steroid injections have been found to make things worse.
PEA has also been found to help with bladder pain. But if a person has pyrrole issues which is usually a symptom of porphyria they should address those issues before taking any type of fats. If they do not it can irritate their bladder. It will also cause a type of acid reflux.
How endothelin contributes to pain and inflammation. Endothelin is usually increased under nitrosative stress. I have posted on it. Increased endothelin levels can lead to high blood pressure. So when high we should try and reduce them. High Indothelin levels can cause asthma, diabetes and cardiovascular disease.
Opium Lettuce also known as wild lettuce has a natural pain killer in it that is non addictive. It is similar to opium and has been used to break opium addiction and has been shown to reduce withdrawal. It also reduces inflammation. The only toxicity I have seen is when people have purified the sap and smoked it. Also a few who consumed much too much. There were no fatalities that I could find documented.
This one actually surprised me. I set out to prove that using magnets for pain and inflammation was crazy. I found none that showed no effects and most studies showed magnets improved blood flow , promoted healing and reduced inflammation.
Additives in food, drugs like fluoroquinolone, farm toxins which have been found to be high in our food supply can cause high glutamate levels. This cause headaches, anxiety, difficulty sleeping, inflammation and systematic pain.
Many things can set off a cytokine storm. This causes systematic inflammation and pain. Vaccine injury is a major contributors along with farm chemicals found in our food. Food additives and processed sugar also causes inflammation. I have posted a list of naturals that reduce inflammatory cytokines.
If you have certain metabolic issues like protenuria, porphyria or sulfation issues which they claim is genetic but I have seen many recover from it when they have detoxed fluoroquinolones or glyphosate. Some may have to avoid meat for a while until they correct the metabolic issues.
Oxalates cause a lot of pain and inflammation. They can be produced endogenously. The problem with endogenous oxalates they block metabolic pathways causing even more oxalates to be produced. It becomes a cycle that is difficult to break. Oxalates cause leaky gut which adds to the oxalate burden by permitting oxalates that are consumed to enter our blood streams. Another thing that contributes to high oxalates is a loss of the oxalate digesting bacteria from our guts. The loss of oxalate digesting bacteria is caused by antibiotics and farm chemicals in our foods. Also heavy metals found in food grown in contaminated soil can kill our oxalate digesting bacteria. Oxalates prevent the gut from healing making the cycle even more difficult to break. I have posted on how to overcome this.
Mugwort is an amazing plant. It has been shown to heal the liver, brain, and reduce inflammation. It increases GABA which reduces pain. It kills many pathogens and has been shown to be very effective against cancer.
There are many different cannabinoids found in a variety of plants. The most well known is found in cannibis. Not all benefit from the cannibinoids in cannabis. But many do and it has been shown to be extremely effective against cancer.
Many things they claim are genetic can be corrected and I have posted on that. Things that may be genetic usually do not present themselves unless a number of issues have built up and cause a synergistic effect. Correcting those problems usually will stop any the supposed flawed gene from presenting itself.
Interstitial Cystitis is like all forms of chronic illnesses rolled into one. Studies have found that it is best to listen to the patient on what works and what does not. Also they have shown naturals work better.
I was never one to leave them inject me with steroids. All those I knew who got steroid injections I would see a dramatic decline in their health shortly after so I have no confidence in their safety or effectiveness.
Increased BH4 levels can raise pain levels. They inhibit it in this study which can have many negative health effects. I have posted on correcting BH4 by taking the nutrients needed to support it. Upregulated BH4 also upregulates the CBS pathway. This can effect the Pentose Phosphate Pathway which can lead to diabetes, heart disease and arteriosclerosis.
When getting treated for infection it can set off sepsis which I covered under my endotoxemia post. Sepsis can set off mast cell activation syndrome which causes high histamine. It can also cause high substance P levels, high mTOR levels and set off an inflammatory cytokine storm. Vaccine injury can also do this. When getting treated for infection it is safer to start at low doses and slowly work up to higher doses. This also includes when taking naturals for infection.
Passion Flower has been shown to reduce pain and have neuroprotective effects but I have seen studies that have shown it can damage the liver though it was not clear if it was reversible or the amount of passion flower that was used. I know many who have used it and said it really helped them but once they healed they discontinued use. I would not recommend frequent or high dose usage.
Acute pain, possibly very severe, that occurs very suddenly. It may last a few minutes, or many hours
Pain is usually located behind your breastbone, but may occur in the upper right abdominal area
Pain between your shoulder-blades
Chills and fever
Nausea and vomiting
Many of the things in this list help reduce my pain.
St. Johnswort reduces pain inflammation and has antioxidant properties. I seen studies that claimed it was toxic to the liver. Those studies where vague as to methodology and lacking data. Most studies I have read on St Johnswort showed it to be non toxic and does the opposite it actually reduce inflammation in the liver.
I have never tried Kratom but many of my friends have and they have really benefited from it. They claim it is addictive but none of them became addicted. I do know something in the kratom that is green irritates IC sufferers bladder and my friends said the red kratom did not irritate their bladders.
Most call P. Major broad leaf plantain and P. Lanceolata narrow leaf plantain. The health benefits are similar but P. Major taste much better though I like the taste of both, I prefer P. Major. Or P Rugelii which looks similar to P. Major but it has a purple or red color at the bottom of the leaf stem. It is the mildest tasting of the three and has a somewhat sweet taste. This is another herb that is a power house when it comes to healing. It can help balance the immune system. Helps with inflammation and poor blood circulation. Kills many pathogens and has amazing healing abilities. It can kill gangrene so the phytochemicals are being researched in it. It also fights chronic illnesses even cancer. I have found it works fantastic for rashes especially poison ivy. To prevent a rash I will take Jewel Weed and use the juices because it is good at breaking up the urishiol. It doesn’t prevent the rash though but will reduce the effects of the urishiol in poison ivy or poison sumac. I then use the juice from plantain to prevent the a rash. It contains biacalein which is what give sculletaria it’s healing benefits.
It contians biacalein and aucubin. This gives it many healing abilities along with the ability to fight pathogens. Biacalein has been shown to reverse some injury to the cardiovascular system and the lungs.
This is not medical advice and should not be taken as such. I am posting this for educational and informational purposes.
Calcium Glycerophosphate – helps with the ph of urine. Helps fight pathogens also helps with bone healing. You do not want to over alkalize the bladder. Most pathogens especially Candida when it is in it’s pathogenic form prefers and flourishes in an alkaline environment but the good bacteria cannot tolerate it. This helps if you have acidosis and would probably be about the only reason I would take it. It has been shown to strengthen bones and teeth. Do not take too often or for too long because it can inhibit absorption of other nutrients. It has been shown to reduce the symptoms of mental illness, improve memory and cognitive function. It helps heal leaky gut. It inhibits absorption of lead and alunimun into the body. It also helps ease bladder pain. It reduces inflammation and fights cancer. It increases IL 10 which can be inhibited by many pathogens to stealth themselves from the immune system.
Calcium-D-Glucarate this reduces ammonia levels in the body. It helps remove toxins from the body. It can help remove carcinogenic estrogen from the body. It reduces stress on the liver which causes a reduced need for cholesterol which will reduce cholesterol levels. It also reduces the risk of cancer. It also prevents toxins from being absorbed in the digestive system. It improves glucuronidation.
Phospholipids – needed for healing and protecting the cells in the body. Also helps transport nutrients through the body. Breaks up biofilms. It is good to alternate sources because each has their benefits. Some good sources of phospholipids are olive oil, ghee, evening primrose oil etc. Try to reduce sources of Omega 6 if it gets too high in the body it will cause inflammation instead of reducing it. Omega 3 needs to be higher. If you get ill, have bladder pain or get indigestion when you consume fats then you may have a blocked Pentose Phosphate Pathway or you have Pyrole issues that need addressed. There are many types of fats. I will do a seperate article on that.
Cholesterol – needed to heal in all parts of the body. The heart and brain cannot function without it. If your oxLDL is high it indicates you have inflammation or high oxidative stress levels. Cholesterol is an antioxidant and high LDL is a sign your antioxidant systems is working but something is causing inflammation or oxidative stress. Lowering chlolesterol prevents the body from healing. Address what is causing it, also not drinking enough water can also cause high LDL levels. Reducing cholesterol is not a good idea. Studies have shown memory and cognitive function decline as cholesterol levels decline. Muscles start to deteriorate if they do not get enough cholesterol. I did a post on cholesterol that gets into more detail.
Arrowroot – helps the cells use cholesterol more affectively especially in the bladder. It reduces oxLDL levels. It has many of the nutrients to support our metabolic pathways. Cholesterol is needed for our bodies to heal. Oxidative stress prevents our cells from being able to use cholesterol properly. Arrow root helps improve the absorption and use of cholesterol in the body. This reduces the bad cholesterol like oxLDL. There are many types of roots used from a variety of plants but most have the same benefits. Helps heal the gut and bladder because it has nutrients to support the health of mucous membranes. When processed into flour it losses many of it’s vitamins but retains minerals. Many of the benefits from arrowroot are from drinking teas made from arrowroot. Most of these because of the type of starch found in roots would help heal the gut. Seems those in the Canna family, Maranta Arundinacea are the best ones to use.
Larazotide Acetate – reduces symptoms of celiac disease has been shown to reduce bladder pain. Though I do not like pharmaceuticals because the pharmaceutical companies have a history of covering up the ill effects of their drugs and often times it turns out the side effects are worse then their illness. This one seems to show promise.
Ashwagandha (Withania Somnifera)– improves thyroid and adrenal health. Reduces brain cell degeneration. Improves endurance and stamina. This is an herb you want to back off using and only take maintenance doses once you start healing. Ashwagandha reduces stress hormones. Ashwagandha also balances sugar levels in the body. Improves memory and heals the brain. It contains withanolides which are also found in plants in the same family like Tomatilla and ground cherries. Has many antioxidants which help reduce inflammation and histamines that results in lower oxidative stress, lower oxLDL and better immune function. It increases male fertility and fights cancer. It simulates thyroid hormones. It increases red and white blood cell counts. It also kills pathogens so you could herx when you first take it. Though there are no apparent side effects homeostasis should always be the goal. When you feel better a rule that has helped me is to stop taking something and start taking maintenance doses once in a while to keep things working.
Mushrooms like cordyceps, reishe and many others contain anti pathogen properties and have glycoprotein which is more easily used by the body for energy. Glycoproteins also promote better cell to cell communication. They also contain beta glucan which can stimulate the immune system to help fight pathogens. If you have a T cell imbalance they restore T cell balance in the body. Exposing mushrooms to sunlight before you eat them causes them to produce vitamin D. They kill cancer because the glycoproteins improve our bodies cell to cell communication. Mushrooms are also hepatoprotective.
Fulvic Acid – helps repair chromosome damage. Can increase ammonia and hydrogen peroxide levels so make sure your oxidative stress levels are down. Make sure you detox before using it, it can cause the release of toxins from the cells to be excreted. It restores autophagy. Because it restores autophagy it benefits the whole body. It helps balance our gut bacteria and is good for those who have SIBO. Fulvic Acid also improves nutrient absorption. In inhibits COX and reduces homocystein which would reduce inflammation and help with MCAS. I get mine from organic blackstrap molasses. It has a high fulvic acid content. It also helps fight cancer. There is a draw back to fulvic acid. If you take too much it can actually increase oxidative stress instead of decreasing it. Use in moderation. Also if you are deficient in Selenium it will increase oxidative stress so make sure you get enough selenium.
It breaks up Tau Fibrils in the brain so would probably break up other illnesses cause by misfolded proteins which causes Alzheimer’s. This is one of the most common problems in those who suffer from interstitial cystitis.
Taurine – usually low in vegetarians, has a sedative affect. Helps adrenals by reducing stress hormones. Has sedative affects. Needed for cardiovascular function, cellular function, eyes, skeletal muscle and central nervous system. Protect the bladder from stress induced injury. It is also an antioxidant and anti-inflammatory. It reduces oxidative stress so would help with the many chronic illnesses that come with it. Helps regualte the amount of water in our cells and is part of the bile system. If you are deficient in taurine it could effect your gall bladder which in turn could cause gall stones and high oxLDL. There is so many benefits to taurine I am not going to list them. I have found no studies on negative effects caused by it.
Ginkgo Biloba – before I mention the benefits I need to give a warning. Taking it for too long or in high doses may damage the liver. I say may because the studies showing it harms the liver where poorly designed so I could not draw a conclusion. Their are studies showing it’s safety but they did not test on liver enzymes and function so I cannot draw a conclusion from those either. helps adrenals by lowering stress hormones. Improves memory and blood circulation. I got a headache the first few times I took this then I could think much clearer. The is one that you are not supposed to take often or for extended periods of time. If taken for too long or to high a dose it can damage the kidney and liver. It helps with interstitial cystitis and reduces inflammation. It also fights infection. It enhances memory and cognitive function. Helps with Raynauds disease which is cause by damage or inflammation in the blood vessels which causes restricted blood flow. It can also be caused by carditits from sepsis or infection. Some drugs can cause it like fluoroquinolones one of the most harmful drugs on the market. If you have epilepsy most recommend you do not take it. The first couple of times I took it I got a really bad headache. It improves mood and energy levels. Heals, hemorrhoids, fights fibromyalgia and reduces symptoms of asthma. Then about the third day my brain fog from the Lyme started lifting and I could think more clearly and concentrate better. If you are allergic to poison ivy you may be allergic to this. I am allergic to poison ivy but did not react but they say some do.
Azo (Phenazopyridine) – I do not recommend because it can damamge the liver. This is used for those who have bladder pain. It does help with some urinary tract infections though but can make others worse. Many seemed to have better results with Uristat when it came to bladder pain and it does not stain like phenazopyridine.
PPQ (Pyrroloquinoline Quinone) enhances mitochondria function. Improves memory, protects and heals nerves, improves sleep, mood and reduces fatigue.Reduces symptoms of fibromyalgia,ms,als etc. Reduces urinary tract problems. It is a REDOX agent, neutralizing oxidants then it gets recycled by glutathion. It reduces inflammation and enhances mitochondria function. It prevents NAFL and protects from the inflammation caused by the western diet and our toxic food.
Organic unsulfured Blackstrap Molasses has too many benefits to list but I will try to list some of them. It promotes overall body health. Speeds up wound healing and helps with anemia. Has many nutrients needed for the metabolic pathways. Ease into using it because when the metabolic pathways open your body will start to detox. You do not want to open the flood gates too fast but open them slowly until the toxin levels are low enough for your body to be able to keep up. Also Blackstrap Molasses is high in fulvic acid and you do not want to get your fulvic acid levels to high. It has many benefits but many nutriets lose their benefits if over consumed.
We need a variety of oligosaccharides because different members of our gut bacteria need different oligosaccharides. I found when I was able to start eating again I had to ease into adding these because I bloated at first. As my good bacteria got established from eating the oligosaccharides the bloating and gas stop occurring. It took me 3 months before I felt no ill effects from getting oligosaccharides. I knew it was necessary to get my good bacteria established. When we have too much of one specific bacteria or if candida is in it’s pathogenic form we will have too many methane producing and sulfur digesting bacteria. This causes high hydroxy radical levels in the body and also causes high sulfate levels which will result in high ammonia levels in the bladder and digestive system. This causes Candida to go from commensal to pathogenic form. When Candida is in pathogenic form it alkalizes which feeds it even more. We have to work on restoring the ph of our bladder and digestive system back to acidic. A few strains of lactobacillus regulate the ph of our bladder. If we are low or deficient in them then we cannot fight pathogens because they prefer an alkaline environment. Our food does not get broke down as quickly and ferments instead of digesting.
This is for educational and informational purposes and should not be taken as medical advice. If in doubt don’t. If you do not know a plant well do not use it.
I do not like the taste of Yarrow but I do know eating it has had noticeable effects. I noticed I had increased energy levels. There are sites that claim it lowers blood pressure but my friends who had hypertension experienced a rise in their blood pressure when they used Yarrow. Has has been used for many illnesses even hemorrhoids. There are claims that when applied to wounds it stops bleeding. There are many species of Achillea but I am fimiliar with A. Millefolium. The others chemical makeup is very similar.
They claim it reduces blood pressure through it’s diuretic properties but I have seen it increase peoples blood pressure. One thing I did notice the ones it increased blood pressure in did not drink adequate amount of water.
Can cause problems in those with high glutathione levels. This study is viewed as negative but it appears by their results it reduce quinone and would help with interstitial cystitis. If I had time I would get into more detail and explain why.
This is what I notice in the other study and why I said it would help with interstitial cystitis. It has NO scavenging abilities. The also would help with kidney disease were people have excessive bleeding.