This is not medical advice I am posting this for educational and informational purposes.
HSP70 has it’s benefits if done in moderation. Always keep in mind homeostasis should be the goal.
HSP70 is found to be high in those with skin disorders. So those with dermititis would want to reduce HSP70
https://www.ncbi.nlm.nih.gov/pubmed/19109201
HSP70 redulates angeotensin II, it reduces inflammation in the renal system but if a person is deficient in vitamin D it could cause inflammation in the cardiovascular system.
HSP 70 is essential for preventing salt induced hypertension.
https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14334
HSP70 helps regulate the antioxidant system.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971240
HSP70 helps regulate cellular redox.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971240
This is how selenium, vitamin C and sodium bicarbonate reduce oxidative stress by increasing HSP.
https://www.ncbi.nlm.nih.gov/pubmed/29442224
https://www.ncbi.nlm.nih.gov/pubmed/28386897
Protects from neurological disorders.
http://m.pnas.org/content/112/52/16006.full
HSP70 can prevent thrombosis (blood clotting) without causing anemia.
https://academic.oup.com/cardiovascres/article/110/3/309/1744740?searchresult=1
Increasing HSP70 also helps with liver disease cause by B-thalassemia which causes liver fibrosis.
Good information on ways of increasing or decreasing HSP70
https://www.selfhacked.com/blog/heat-shock-proteins-hsp70-increase-decrease/
Heat shock protein protects the cells from oxidative stress so can actually protect cancer. In this case it would probably be beneficial to reduce HSP70. Homeostasis should be the goal.
https://www.ncbi.nlm.nih.gov/books/NBK6084/
https://www.nature.com/articles/4401124?cookies=accepted
Sulfation is very improtant in the regulation of HSP. If we have sulfation issues or high sulfite levels to need to be addressed for HSP to function properly. Sulfation issues also effect the Nrf2 pathways which is also responsible for HSP homeostasis. Nrf2 is the master regulator of the antioxidant system.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302153/
Induction of HSP70 may help with Lou Gehrig’s disease.
https://academic.oup.com/brain/article/139/5/1417/2468726?searchresult=1
HSP70 protects the liver. They claim fructose increases HSP70 , that may be true for unprocessed fructose found in fruits and vegetables but processed fructose has been found to have a severe negative impact on health.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568217/
Heat shock protein is stimulated during exercise. Heat shock protein has been shown to reduce hot flashes caused by menopause.
mTOR homeostasis is very important for the proper regulation of heat shock proteins.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154417/
Some infections can cause HSP instability.
http://jvi.asm.org/content/79/4/2033.full
HSP70 is responsible for cleaning up protein aggregates in the body. When inhibited it can cause health problems.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(16)30365-3
http://dmm.biologists.org/content/7/4/421
HSP90 over activation can contribute to neurodegerative disease.
https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-5-24
Low HSP70 levels is associated with frail health.
https://bmcimmunol.biomedcentral.com/articles/10.1186/1471-2172-12-24
How heat shock proteins regulate cell death.
https://www.nature.com/articles/1207114
Oral HSP are used to treat autoimmune disease and cancer.
https://www.ncbi.nlm.nih.gov/pubmed/9559977
https://www.hindawi.com/journals/ad/2012/486069/
HSP70 helps reduce inflammation in diseases like IBD.
https://www.ncbi.nlm.nih.gov/pubmed/26467144
https://academic.oup.com/ps/article/91/4/790/1576718
Fasting increases HSP70
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0110748
HSP90 contributes to the ill effects of oxalates.
https://link.springer.com/article/10.1007/s00775-016-1355-x
https://www.ncbi.nlm.nih.gov/pubmed/20210657
HSP70 protect from oxalate toxicity.
https://link.springer.com/article/10.1007%2Fs00240-007-0130-4
Inhibiting HSP90 helps fight viruses.
http://jvi.asm.org/content/87/18/10126.full
HSP90 inhibitors helps fight cancer.
https://www.ncbi.nlm.nih.gov/pubmed/25912253
https://www.sciencedirect.com/science/article/pii/S0167488910002533
High HSP90 levels contribute to COPD.
http://erj.ersjournals.com/content/51/2/1700386.long
HSP70 is downregulated in fibrosis.
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.26423
Some chemicals found in gensing inhibit HSP90
https://linkinghub.elsevier.com/retrieve/pii/S0304-3835(17)30648-1
Geranium Thunbergii inhibits HSP90
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074266
Thunder god vine inhibits hsp90
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823561/
Green tea inhibits HSP90 which helps with interstitial cystitis but if you drink too much it will increase histamine levels which would have the opposite effect.
http://www.ucmg.net/wellness/holistic_articles/nutrients/Green-tea_Natures-exlixir.htm
http://iai.asm.org/content/84/4/1176.full.pdf
Inhibiting HSP90 also helps with Lupus.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127361
HSP90 is needed for many cellular processes so homeostasis should always be the goal.
https://www.ncbi.nlm.nih.gov/pubmed/23806880
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004347/
