Reducing Pain.

This is not medical advice I am posting this for educational and informational purposes.

There are many things that can cause pain. It is usually a synergistic effect of things that have built up and caused high inflammatory cytokines, mast cell activation syndrome, high substance P levels, even metabolic issues can cause pain. I have posted on those things and to reduce pain and start healing they must be addressed. I have much more detailed notes on reducing pain but figure this would be a good start.

Many pain killers have been linked to chronic illness , for example tylenol has been linked to liver disease along with many pharmaceuticals for pain. Opoiods have been shown to increase inflammation and add to pain. Even steroid injections have been found to make things worse.

https://www.naturalnews.com/2018-07-31-harmless-painkillers-like-ibuprofen-now-linked-to-huge-increase-in-risk-of-sudden-heart-attack.html

http://ushealthmagz.com/2018/05/01/fda-warns-about-dangers-of-epidural-steroid-injections-for-back-pain/

This is a list of things that can cause inflammation which leads to chronic pain. I have posted information on most of these.

http://www.biology-pages.info/I/Inflammation.html

Coffee acts as an opioid. Those with carditits or tachycardia are supposed to avoid caffeine.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546775/

Vitex acts on the opioid receptors.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993511/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081944/

CBD and PEA help with gut pain and inflammation.

http://www.clinsci.org/content/131/21/2611.long

https://www.sciencedirect.com/science/article/pii/S0028384317303249?via%3Dihub

https://www.healthrising.org/blog/2014/09/19/palmitoylethanolamide-pea-medical-food-fibromyalgia-chronic-fatigue-syndrome-mecfs/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531370/

https://www.sciencedirect.com/science/article/pii/S0028384317303249?via%3Dihub

PEA has also been found to help with bladder pain. But if a person has pyrrole issues which is usually a symptom of porphyria they should address those issues before taking any type of fats. If they do not it can irritate their bladder. It will also cause a type of acid reflux.

Interstitial Cystitis (IC), bladder pain syndrome (BPS), its cause and treatment

How endothelin contributes to pain and inflammation. Endothelin is usually increased under nitrosative stress. I have posted on it. Increased endothelin levels can lead to high blood pressure. So when high we should try and reduce them. High Indothelin levels can cause asthma, diabetes and cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630124/

https://www.selfhacked.com/blog/endothelins/

mTOR inhibitors reduce endothelin. I have mentioned mTOR in other post if you do a search in my profile.

https://www.jhltonline.org/article/S1053-2498(16)00574-X/fulltext

http://diabetes.diabetesjournals.org/content/60/8/2061

Endothelin is high in cirrhosis of the liver and COPD.

http://www.clinsci.org/content/105/2/227

https://www.resmedjournal.com/article/S0954-6111(03)00129-X/fulltext

High substance P levels can cause mast cell activation syndrome, inflammation and pain. I have posted on substance P. Magnesium helps reduce endothelin.

http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1933737

https://www.wellnessresources.com/news/magnesium-is-essential-for-preventing-substance-p-overload

http://www.drwardbond.com/dr-bs-blog/trichodynia-pain-and-substance-p

http://mcr.aacrjournals.org/content/11/3/294

Chamomille reduces substance P.

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0043-106742?device=mobile&innerWidth=980&offsetWidth=980

Cox increased pain and inflammation. Natural Cox inhibitors reduce pain and inflammation.

http://www.chiro.org/nutrition/FULL/Natural_COX-2_Inhibitors.shtml

https://www.motherearthnews.com/natural-health/herbs-containing-natural-cox-2-inhibitors-zmaz00djzgoe

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873812/

Nutmeg is a Cox inhibitor and reduces pain. It has a potent canidbinoid that can cause hallucinations, seizures and even death if taken in to high amounts.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848392/

Opium Lettuce also known as wild lettuce has a natural pain killer in it that is non addictive. It is similar to opium and has been used to break opium addiction and has been shown to reduce withdrawal. It also reduces inflammation. The only toxicity I have seen is when people have purified the sap and smoked it. Also a few who consumed much too much. There were no fatalities that I could find documented.

https://www.herbs2000.com/herbs/herbs_lettuce_opium.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031874/

https://returntonow.net/2017/10/11/opium-lettuce-natures-best-painkiller-growing-backyard/

Aloe Vera is neuroprotective and reduces inflammation.

http://www.em-consulte.com/article/1043973/alertePM

This one actually surprised me. I set out to prove that using magnets for pain and inflammation was crazy. I found none that showed no effects and most studies showed magnets improved blood flow , promoted healing and reduced inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818436/

Additives in food, drugs like fluoroquinolone, farm toxins which have been found to be high in our food supply can cause high glutamate levels. This cause headaches, anxiety, difficulty sleeping, inflammation and systematic pain.

https://healthyeating.sfgate.com/glutamate-pain-8891.html

https://www.physiology.org/doi/abs/10.1152/ajprenal.00297.2015?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

Vitamin C can alleviate pain but in high doses it can cause oxalates and break down read blood cells.

https://www.ncbi.nlm.nih.gov/pubmed/28902622

Many things can set off a cytokine storm. This causes systematic inflammation and pain. Vaccine injury is a major contributors along with farm chemicals found in our food. Food additives and processed sugar also causes inflammation. I have posted a list of naturals that reduce inflammatory cytokines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785020/

https://www.hindawi.com/journals/cripe/2017/9461315/

http://ijme.in/articles/human-papillomavirus-vaccines-complex-regional-pain-syndrome-postural-orthostatic-tachycardia-syndrome-and-autonomic-dysfunction-a-review-of-the-regulatory-evidence-from-the-european-medi/?galley=html

http://vaccineimpact.com/2015/15-year-old-vaccinated-by-force-with-gardasil-now-suffers-from-paralysis-and-pain/

This woman listed things that helped her friend with interstitial cystitis pain. All the things she mentions also helped me.

https://hubpages.com/health/Interstitial-Cystitis-Life-Without-Pain

If you have certain metabolic issues like protenuria, porphyria or sulfation issues which they claim is genetic but I have seen many recover from it when they have detoxed fluoroquinolones or glyphosate. Some may have to avoid meat for a while until they correct the metabolic issues.

https://www.youtube.com/watch?v=SaQpaJ-azKk

Toning the vagus nerve can reduce pain.

https://upliftconnect.com/toning-vagus-nerve-heals-pain/

Oxalates cause a lot of pain and inflammation. They can be produced endogenously. The problem with endogenous oxalates they block metabolic pathways causing even more oxalates to be produced. It becomes a cycle that is difficult to break. Oxalates cause leaky gut which adds to the oxalate burden by permitting oxalates that are consumed to enter our blood streams. Another thing that contributes to high oxalates is a loss of the oxalate digesting bacteria from our guts. The loss of oxalate digesting bacteria is caused by antibiotics and farm chemicals in our foods. Also heavy metals found in food grown in contaminated soil can kill our oxalate digesting bacteria. Oxalates prevent the gut from healing making the cycle even more difficult to break. I have posted on how to overcome this.

https://www.alwayswellwithin.com/2010/04/27/high-oxalate-foods-can-trigger-pain-and-inflammation/

https://myersdetox.com/oxalates-their-influence-on-chronic-disease/

https://functionaldiagnosticnutrition.com/top-signs-you-may-have-oxalate-sensitivity/

Lacking certain gut bacteria and having to many of others can cause pain.

http://atm.amegroups.com/article/view/13313/13673

https://www.healio.com/gastroenterology/irritable-bowel-syndrome/news/online/{bb454dd3-01bf-4720-a01e-912c62d09062}/probiotic-yeast-improves-abdominal-pain-bloating-in-ibs-c-patients

https://www.nature.com/articles/srep26083

https://www.nature.com/articles/nm1521

Even in sickle cell the gut has been linked to pain.

https://sicklecellanemianews.com/2017/11/16/study-links-pain-in-sickle-cell-disease-to-increase-in-a-type-of-gut-bacteria/

Mugwort is an amazing plant. It has been shown to heal the liver, brain, and reduce inflammation. It increases GABA which reduces pain. It kills many pathogens and has been shown to be very effective against cancer.

https://draxe.com/mugwort/

There are many different cannabinoids found in a variety of plants. The most well known is found in cannibis. Not all benefit from the cannibinoids in cannabis. But many do and it has been shown to be extremely effective against cancer.

https://www.naturalhealth365.com/chronic-illness-cbd-2276.html

Cannabinoid in carrots and parsley, reduces inflammation and pain.

https://www.ncbi.nlm.nih.gov/pubmed/20206138

Magnolia contains a cannabinoid that reduces pain and inflammtion.

A-Pinene is a cannibinoid found in pine and it reduces pain and inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/26119957

https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-135

Lemon grass contains myrcene which is cannabiniod like.

https://www.ncbi.nlm.nih.gov/pubmed/1753786

Exercise helps release endogenous cannabinoids.

http://jeb.biologists.org/content/215/8/1331

Many things they claim are genetic can be corrected and I have posted on that. Things that may be genetic usually do not present themselves unless a number of issues have built up and cause a synergistic effect. Correcting those problems usually will stop any the supposed flawed gene from presenting itself.

http://www.beyondmthfr.com/a-genetic-cause-of-pain-and-anxiety-comt-mao-and-mthfr/

Drugs are one of the major causes of damage leading to pain in the body. Statins and fluoroquinolones are two of the major culprits.

https://www.healthline.com/health/what-is-statin-induced-myopathy-or-muscle-pain

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/766834

I have covered mTOR in other post. High mTOR levels can be a cause of pain and inflammation and has been found to be high in many inflammatory diseases.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084610/

Interstitial Cystitis is like all forms of chronic illnesses rolled into one. Studies have found that it is best to listen to the patient on what works and what does not. Also they have shown naturals work better.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783700/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772357/

I was never one to leave them inject me with steroids. All those I knew who got steroid injections I would see a dramatic decline in their health shortly after so I have no confidence in their safety or effectiveness.

http://ushealthmagz.com/2018/05/01/fda-warns-about-dangers-of-epidural-steroid-injections-for-back-pain/

High adrenal levels can be the result of toxins, vaccine injury, excess stress or infection. It has been found to be common in those with inflammatory diseases.

https://onlinelibrary.wiley.com/doi/abs/10.1002/nau.22542

Mindfull meditation has been shown to reduce pain.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067184/

It is very important to try and get over trauma because it can lead to chronic pain and health issues.

https://www.ncbi.nlm.nih.gov/pubmed/28107899

Increased BH4 levels can raise pain levels. They inhibit it in this study which can have many negative health effects. I have posted on correcting BH4 by taking the nutrients needed to support it. Upregulated BH4 also upregulates the CBS pathway. This can effect the Pentose Phosphate Pathway which can lead to diabetes, heart disease and arteriosclerosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288148/

TMJ a disorder where there is pain in the jaws can be caused by infection especially tick born illness. Lyme disease and some tick born illness that can be even worse can cause systematic illness.

http://www.tmj.org/site/page?pageId=193

https://canlyme.com/lyme-basics/symptoms/

Mold

https://www.merckmanuals.com/home/infections/fungal-infections/mucormycosis

Tylenol is very hard on the liver. There are safe natural alternatives to tylenol.

https://jennifermargulis.net/tylenol-alternatives-better-safer-remedies/

Botox has been found to help those with severe bladder pain.

https://health.clevelandclinic.org/botox-can-offer-women-help-painful-sex/

Acetyl-L-Carnatine has been shown to help with neurological pain.

https://www.naturalmedicinejournal.com/journal/2010-08/therapeutic-effects-acetyl-l-carnitine-peripheral-neuropathy-review-literature

Lyme and other tick born illness effects the whole body. That is why many with Lyme have interstitial cystitis.

https://lymemd.blogspot.com/2009/06/interstital-cystitis-and-lyme.html?m=1

Lyme treatment often times fails that is why many of us turn to alternatives.

http://danielcameronmd.com/5548-2/

When getting treated for infection it can set off sepsis which I covered under my endotoxemia post. Sepsis can set off mast cell activation syndrome which causes high histamine. It can also cause high substance P levels, high mTOR levels and set off an inflammatory cytokine storm. Vaccine injury can also do this. When getting treated for infection it is safer to start at low doses and slowly work up to higher doses. This also includes when taking naturals for infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111180/

NSAIDs can damage the gut if taken for too long which can lead to many forms of chronic illness.

https://jeffreydachmd.com/2014/06/nsaids-small-bowel-leaky-gut/

Cissus has been shown to reduce pain.

https://www.organicfacts.net/health-benefits/other/cissus-quadrangularis.html

This article discusses the immune system and how it can lead to chronic pain. I have posted on the immune system with links on how to balance it.

https://phoenixrising.me/archives/13083

Pau D Arco helped me a lot. Fights inflammation and many pathogens including mycoplasma.

https://draxe.com/pau-darco-tea/

Most plants in the Mallow family reduce pain and inflammation.

https://www.omicsonline.org/open-access/the-effect-of-malva-neglecta-on-the-reduction-of-inflammatory-agents-in-patients-with-osteoarthritis-2168-9547-1000135.php?aid=61436

Rooibos is an amazing herb it kills infections especially in the lungs and reduces inflammation and histamines.

https://www.worldscientific.com/doi/abs/10.1142/S0192415X15500573?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

Bacopa is another amazing herb that reduces inflammation , heals blood vessels and has many other benefits.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319078/

I do not like supplementing things the body can produce but in some instances supplementing may be necessary. Melatonin has many healing properties. There are ways to stimulate melatonin production.

http://www.fupress.net/index.php/ijae/article/view/21483

Feverfew reduces pain, fights the flu and common cold. It can be addicitive and cause withdrawal called toxic withdrawal syndrome if taken for too long.

https://www.drweil.com/vitamins-supplements-herbs/herbs/feverfew/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309307/

A variety of plants and their effects on pain. I seen lemon balm mentioned many of my friends said it has helped them.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597072/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111180/

https://nourishholisticnutrition.com/herbs-to-reduce-insomnia-and-chronic-pain/

https://www.health.harvard.edu/staying-healthy/foods-that-fight-inflammation

Japanese honeysuckle reduces inflammation and histamines.

https://www.hindawi.com/journals/ecam/2015/905063/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923575/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765429/

With some types of illness we can develop high glutamate levels. This can make it feel like our head is going to split open. Burdock root can reduce the symptoms of high glutamate levels.

https://www.ncbi.nlm.nih.gov/pubmed/24956398

Purslane is a super food. It has almost all nutrients needed by the body. It reduces inflammation and is very high in mucilage which heals the gut.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321094/?report=classic

Wild Violet has neuroprotective properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967839/

https://www.sciencedirect.com/science/article/pii/S0378874112007362

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613244/

Passion Flower has been shown to reduce pain and have neuroprotective effects but I have seen studies that have shown it can damage the liver though it was not clear if it was reversible or the amount of passion flower that was used. I know many who have used it and said it really helped them but once they healed they discontinued use. I would not recommend frequent or high dose usage.

https://www.ncbi.nlm.nih.gov/pubmed/27693740

Yarrow has pain killing properties and reduces inflammation. Should not be used before bed because it has stimulant effects.

http://www.medicalmedium.com/blog/yarrow

https://wellnessmama.com/7106/yarrow-herb-profile/

Our gut bacteria reduce pain by modulating the opioid and cannabinoid receptors.

Even some of our gut bacteria modulate the opioid and cannabinoid receptors.

https://www.ncbi.nlm.nih.gov/pubmed/17159985

https://www.ncbi.nlm.nih.gov/pubmed/17159985

Symptoms of gall bladder problems.

Symptoms of gallbladder problems.

Acute pain, possibly very severe, that occurs very suddenly. It may last a few minutes, or many hours
Pain is usually located behind your breastbone, but may occur in the upper right abdominal area
Pain between your shoulder-blades
Chills and fever
Jaundice
Nausea and vomiting

Many of the things in this list help reduce my pain.

http://naturalsociety.com/16-natures-best-natural-pain-killers/

Sunlight reduces pain.

https://www.ncbi.nlm.nih.gov/pubmed/27717401

Problems with the vagus nerve which can result from toxins, infection, stress and bad diet can cause chronic pain.

https://forums.phoenixrising.me/index.php?threads/the-vagus-nerve-pain-fm-and-me-cfs-a-cause-of-central-sensitivity.426/

https://upliftconnect.com/toning-vagus-nerve-heals-pain/

This one do your research on. Some things mentioned can have ill effects for some for example SAM-e causes me many problems.

https://www.prohealth.com/library/13-supplements-to-control-lyme-pain-6637

Bad fats cause inflammation.

https://www.drgangemi.com/health-articles/diet-nutrition/nsaids-and-inflammation/

Wild Daisy helps with anxiety but it helped me with pain.

http://www.academicjournals.org/journal/AJPP/article-abstract/176846033725

resveratrol found in grape seed extract reduces bradykinins which can cause inflammation.

https://www.tandfonline.com/doi/abs/10.1517/14728222.11.1.21?journalCode=iett20

Brown seaweed helps with neuropathic pain.

https://www.sciencedirect.com/science/article/pii/S0304394014003413?via%3Dihub

Many sources of pain can be identified by a chiropractor who knows the human body better then most doctors.

https://draxe.com/piriformis-syndrome/

https://www.spine-health.com/conditions/neck-pain/neck-pain-lyme-disease

How our genes can be the cause of our pain.

http://www.beyondmthfr.com/a-genetic-cause-of-pain-and-anxiety-comt-mao-and-mthfr/

Tryptophan decreases pain.

http://healthiculture.com/fibromyalgia-pain-relief-tip-tryptophan/

I have never tried arnica but many of my friend said it has helped them.

https://draxe.com/arnica-oil/

Some have found relief using pectin , it helped me.

http://healthiculture.com/fibromyalgia/painrelief/15pectin/1.php

Nutrient deficiencies can cause pain.

https://healingoracle.ch/2017/05/25/why-magnesium-is-the-most-powerful-relaxation-mineral-known-to-man/

http://www.encognitive.com/node/12179

St. Johnswort reduces pain inflammation and has antioxidant properties. I seen studies that claimed it was toxic to the liver. Those studies where vague as to methodology and lacking data. Most studies I have read on St Johnswort showed it to be non toxic and does the opposite it actually reduce inflammation in the liver.

https://www.ncbi.nlm.nih.gov/pubmed/25851311

https://www.karger.com/Article/Pdf/21265

https://draxe.com/st-johns-wort-uses/

I have never tried Kratom but many of my friends have and they have really benefited from it. They claim it is addictive but none of them became addicted. I do know something in the kratom that is green irritates IC sufferers bladder and my friends said the red kratom did not irritate their bladders.

https://www.painnewsnetwork.org/stories/2016/9/21/survey-kratom-very-effective-for-many-chronic-pain-conditions

 

Thunder God vine has been used by some but I am skeptic because it takes someone knowledgeable to prepare it and there have been incidences of people being poisoned by herbs being prepared wrong.

https://www.drweil.com/vitamins-supplements-herbs/herbs/thunder-god-vine-for-pain/

 

Rhodiola helps with endurance and many said it reduced their pain.

 

https://www.nationalgeographic.com/people-and-culture/food/the-plate/2016/08/long-before-doping-scandals–russians-were-studying-performance-/

 

The effect of high or low histamines.

 

This is not medical advice I am posting this for educational and informational reason only.

 

stock-photo-young-man-sneezes-because-of-an-allergy-to-ragweed-1039352290

There are two sources of histamines endogenous and exogenous. Endogenous means from within or internally so is produced inside the body. Exogenous is introduced to or produced from outside the body. There are health issues with high or low histamines. Narcolepsy is in it’s own class it alternates between high and low histamine.

Histamine has many functions in the body , it is involved in the immune response, regulating physiological function in the gut. It acts as a neurotransmitter in the brain , spinal cord and uterus. It is involved in inflammation and the itching we feel. Histamine is produced by basophils and mast cells types of white blood cells. Histamines increases the permeability of blood vessels to allow white blood cells and some proteins to pass through so they can to engage pathogens in infected tissues.

Histamines generated in granules in mast cells and basophils. Most cells are more numerous in sites of the body that is more prone to injury like the mouth , nose, internal body surfaces and blood vessels. Non mast cell histamine in found in areas such as the brain. Another site of histamine storage and release is in enterochomaffin-like cell (ecl). This is an area in the gastric mucosa. Because of histamines properties it is versatile and able to interact and bind more easily.

The most important role of histamine is immunologic. When the mast cells or basophils have been sensitized to a pathogen by IgE antibodies that attach to their membranes will degranulate when exposed to the appropriate antigen. Certain amines, alkaloids found in plants can displace histamine in granules and cause their release. The break down of amino acids releases amines which are higher in aged meats. Lowering IgE can reduce histamine release.

Histamine is involved in anaphylaxis. Anaphylas is a rapid onset allergic reaction. It can involve itchy rashes, throat and tongue swelling, shortness of breath, lightheadedness, vomiting and low blood pressure. Sometimes they develop over hours. Vaccinations and toxins in our environment and food are known causes of a person developing allergies.

Histamine gated chloride channel is said to be expressed in the hypothalamus, thalamus, and intestines. It has synaptic inhibitory effects. It inhibits the GABA receptors making us more awake. It is also involved in diarrhea.

Histamines are the cause of runny noses. Increased vascular permeability caused by histamines causes fluid to leak from the capillaries into the tissue which leads to runny nose and watery eyes. Allergens can bind to IgE-loaded mast cells in the mucous membrane. This is what causes the sneezing, hyper secretion from glandular tissue, and congested nose from the vasodilation increasing the size of the blood vessels.

Histamine is a neural transmitter that is released from histamine neurons in the hypothalamus (hypothalamus links the nervous system to the endocrine system via the pituitary gland.) . These cells are located in a part of the hypothalamus known as tuberomammilian nucleus. The tuberomammilian nucleus consist largely of histamine neurons and is involved in sexual arousal, learning, memory, sleep and energy balance. The nuerons in this area comprise the brain’s histamine system. It contains nerve fibers that connect it to other areas of the brain.

Enterochromaffin-like cells located within the gastic glands of the stomach that stimulates a certain type of epithelials cell by binding to the end of the H2 receptor. Stimulation of the pariental cells (stomach epithelial cells that secret hydrochloric acid) induces the uptake of carbon dioxide and water from the blood, which is then converted to carbonic acid by the enzyme carbonic anhydrase. Inside the cytoplasm of the pariental cell the carbonic acid readily disassociates into hydrogen and bicarbonate ions. The bicarbonate ions diffuse back through the basilar membrane and into the blood stream while the hydrogen ions are pumped into the lumen of the stomach via specialized pumps. Histamine release is halted when the ph of the stomach starts to decrease. Certain drugs contain antagonist molecules that block the H2 receptor and prevent histamine from binding causing decreased hydrogen ion secretion. Antagonist is a type of receptor ligand that blocks or dampens biological response by binding to and blocking a receptor.

Though histamines have stimulatory effects on neurons it also has suppressive effects against the susceptibility to convulsions, and lesions in the brain.

Those with schizophrenia have increased histamine metabolites in their cerebrospinal fluid and the efficiency of the H1 receptor binding sites is decreased. This can be caused by the toxins in vaccinations, farm chemicals found in our food, heavy metals or inflammation.

Seeing all that histamines do demonstrates the importance of histamine homeostasis. To much can cause many health problems and if inhibited it can cause many health problems. Now knowing the types of histamine receptors will help identify where a specific problem may be. This helps identify the most probably cause of the health problems. For example vaccinations damage certain areas in the brain that that could effect the histamine receptors in our brain that effect our sleep and wake cycle. BT Toxins and the farm chemicals used on them cause leaky gut which can effect histamines throughout the body. Identifying the areas effected by histamines helps narrow the cause down. If you read studies on those who take frequent antihistamines they eventually develop autoimmune disorders which shows the importance of achieving homeostasis so once you have reach homeostasis you should work on maintaining it. Many over do things by continuing the same protocols even those the problem has been corrected which ends up creating other problems.

There are four types of histamine receptors H1-H4.

H1 is expressed in the central nervous system (brain and spinal cord). It is involved in the sleep wake cycle. It promotes wakefulness. It is involved in body temperature regulation, hormone regulation, it can simulate appetite, it constricts the airways, it can increase the sensation of pain, especially in the pelvis and stomach. It can also cause uticaria and itch perception.

H2 is expressed in the central nervous system, stomach, mast cells, vascular smooth muscle cells, cells in the heart and uterus. It has very few effects on the brain, most H2 receptor ligands cannot cross the blood brain barrier. Primarily involved in vasodilation and stimulation of gastric acid and appetite.

H3 Located primarily on basophils in the bone marrow, thymus, spleen and intestines. Plays a role in mast cell chemotaxis (movement cells in response to a chemical stimulant), sensation of itching, cytokine production and secretion, heightened pain in inner organs, involved in inflammation and allergies.

Some H1 agonist can cause drowsiness while H3 agonist can cause wakefulness.

In some illnesses T Cells attack the bodies own cells. H1 and H4 make the symptoms worse will H2 and H3 decrease the symptoms. They believe it is because H2 and H3 help with T Cell differentiation in the immune system. So this would help differentiate between our own cells and a pathogens, preventing the immune system from attacking it’s own cells.

Since histamine are an important part of the immunes system disorders involving histamines can have effects on our immune system. Things like mastocytosis and mast cell activation syndrome. They have some differences but the remedies for them are pretty much the same so I will probably just say mast cell disorders. They are caused by excess mast cell degranulation. Many of these illnesses they claim are genetic but they are finding it is the gut bacteria that modulate those genes that are inherited or that a person may be lacking. Also gene mutations usually do not present themselves unless many other things have went wrong. To reach homeostasis you have to address any other health issues especially leaky gut. When you have high histamines and your nose runs it will be clear or white colored. When it is from and infection it will be different it will be darker colored, I have seen green, brown when the infection is in the tissues, I have even seen yellow.

https://www.healthcoach7.com/2015/04/16/mast-cells-histamine-friend-or-foe/

https://www.nature.com/articles/s41598-017-16019-8

Anaphylaxis is caused by mast cell degranulating.

Histaminosis is a disorder that is caused by a shortage of the enzymes that break down histamine. Diamine Oxidase and Histamine N-methyltransferase.

Diamine Oxidase (DAO) known as histiminase is an enzyme involved in the metabolism, oxidation and inactivation of histamine and other polyamines. Poly amines are found in aged meats and fermented foods. The highest levels of DAO are found in the digestive tract and placenta.

Histamine N-methyltransferase also reduces histamines. The Cytochrome P450 enzymes are involved. Glyphosate inhibits CytP450 Ezymes which raises histamine levels. This is also why it is very important to address inflammation because that can inhibit detoxing.

http://alisonvickery.com.au/what-if-this-was-about-the-liver/

https://www.marioninstitute.org/histamine-intolerance-syndrome/

A deficiency in these enzymes can lead to asthma.

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2222.2007.02769.x

Our gut bacteria can add to the histamines causing asthma , we need to increase our histamine digesting microbiome.

https://www.jacionline.org/article/S0091-6749(16)30709-6/abstract

When levels are low it effects our sleep and we become aggressive.

https://www.nature.com/articles/s41598-017-16019-8

Also our gut bacteria reduce histamines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709439/

https://kresserinstitute.com/gut-flora-food-allergies-connection/

https://wholenewmom.com/health-concerns/low-histamine-probiotics/

https://factvsfitness.com/probiotics-histamine-intolerance/

We must heal our guts

https://bodyecology.com/articles/histamine-hack-how-to-safely-eat-fermented-foods

https://blog.bulletproof.com/how-to-own-your-gut-bacteria-and-fix-leaky-gut-syndrome/

The above mentioned conditions can be set off by toxins like heavy metals and farm chemicals which are found in our food especially glyphosate. It can be set off by pathogens especially Lyme disease. Excess inflammation can increase the risk of these happening along with oxidative stress.

https://www.selfhacked.com/blog/histamine/

DAO deficiencies and high histamines.

http://www.deficitdao.org/en/dao-deficiency/what-is/#.Vtdu0urUV6c.facebook

Symptoms of mastocytosis are anaphylaxis, low blood pressure, hives and swelling, itching, nausea or vomiting, diarrhea, fainting, headache, uterine cramps, bleeding, flushing, and muscoskeletal pain.

https://www.aaaai.org/conditions-and-treatments/related-conditions/systemic-mastocytosis

https://www.mayoclinic.org/diseases-conditions/systemic-mastocytosis/symptoms-causes/syc-20352859

https://arupconsult.com/content/mast-cell-disorders

https://my.clevelandclinic.org/health/articles/5908-mastocytosis

http://mastocytosisawareness.blogspot.com/p/up.html

Pediatric mastocytosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869446/

Test for mastocytosis.

https://tmsforacure.org/tests/

Symptoms of Mast Cell Activation Syndrome are flushing, hives and swelling, nasal itching and congestion, wheezing and shortness of breath, throat itching and swelling, headache, brain fog, cognitive dysfunction, mental issues like anxiety or depression, diarrhea, abdominal pain, bloating, GERD, bone and muscle pain, lightheadedness, rapid heart rate, low blood pressure, uterine cramps or bleeding.

https://tmsforacure.org/symptoms/symptoms-and-triggers-of-mast-cell-activation/

https://www.healthline.com/health/mast-cell-activation-syndrome#causes

https://www.sott.net/article/332968-Could-mast-cell-activation-disorder-be-the-root-cause-of-your-histamine-intolerance

https://link.springer.com/article/10.1007%2Fs11882-012-0322-z

POTS caused by myocarditits can be caused by mast cell activation.

http://www.dysautonomiainternational.org/blog/wordpress/a-tale-of-two-syndromes-pots-and-mcas/

http://hyper.ahajournals.org/content/45/3/385

Symptoms histaminosis most commonly known as histamine intolerance can manifest as intolerance to sulfur, food sensitivities especially gluten, gliaden, and milk products., sensitivity to amines found in aged meats and fermented foods. Gastrointestinal issue, excessive gas, diarrhea, cramps, fatigue, insomnia, noise sensitivity, hives, hypertension, and depression.

https://www.dietvsdisease.org/histamine-intolerance/

http://davidjernigan.blogspot.com/2015/07/histamine-intolerance-not-allergies-may.html

https://www.mindbodygreen.com/0-11175/everything-you-need-to-know-about-histamine-intolerance.html

https://www.marioninstitute.org/histamine-intolerance-syndrome/

https://itchylittleworld.com/are-you-suffering-from-histamine-intolerance/

https://www.marksdailyapple.com/histamine-intolerance/

Diagnosing Guidlines.

https://www.croh-online.com/article/S1040-8428(14)00149-8/fulltext

Fluroquinolone causes mast cell activation.

Can Fluoroquinolones Activate Mast Cells?

The whole body is effected by mast cell activation.

https://jhoonline.biomedcentral.com/articles/10.1186/1756-8722-4-10

High estrogen and low progesterone can cause high histamines. Many toxins like glyphosate and BPA can cause this.

https://www.larabriden.com/the-curious-link-between-estrogen-and-histamine-intolerance/

When you have problems with histamines it is very important to adjust your diet to reduce histamines and amines. Once you reach homeostasis you can slowly reintroduce them back into your diet. Because most of the solutions for addressing the various disorders overlap I won’t mention which disorder it helps because for the most part all will be helped by the things mentioned. Do your research to be better able to develop a protocol unique for you. We are all different and can not do a one size fits all protocol. Most of these symptoms can be caused by gut bacteria imbalance or leaky gut.

https://healinghistamine.com/leaky-gut-the-mast-cell-histamine-crohns-disease-connection/

https://blog.bulletproof.com/why-yogurt-and-probiotics-make-you-fat-and-foggy/

http://alisonvickery.com.au/anti-histamine-foods/

http://www.mastcellmaster.com/publications.php

Lectins, leaky gut and histamines.

http://www.histamine-intolerance.info/low-histamine-diet/#undefined.gbpl

Specific diets like the paleo diet should only be used until the problem has been corrected.

http://alisonvickery.com.au/why-olive-oil-and-a-paleo-diet-increases-dao/

https://www.selfhacked.com/blog/deal-histamine/

https://healinghistamine.com/reacting-to-everything-this-could-be-why/

Melatonin reduces histamines.

https://healinghistamine.com/melatonin-mast-cells-and-histamine/

Vaccinations cause allergies and getting the measles protects against allergies.

http://pediatrics.aappublications.org/content/123/3/771?sso=1&sso_redirect_count=1&nfstatus=401&nftoken=00000000-0000-0000-0000-000000000000&nfstatusdescription=ERROR%3a+No+local+token

https://www.ncbi.nlm.nih.gov/pubmed/10714532

https://www.karger.com/Article/Abstract/254898

https://www.karger.com/Article/Abstract/24196

https://www.medical-hypotheses.com/article/S0306-9877(04)00044-1/fulltext

Genetically modified foods increase amines similar to those caused by food poisoning. This would cause gut issues and a rise in histamines.

https://www.ncbi.nlm.nih.gov/pubmed/27991589

Luteolin prevents mast cell degranulation.

https://www.naturalhealthnews.uk/herbal-remedies/2015/01/black-ginger-extract-could-help-control-psoriasis-flares/

https://www.jacionline.org/article/S0091-6749(14)01574-7/abstract

Tick born illness can induce mast cell activation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC96436/

Caffeic Acid reduces histamines. Caffeic acid is high in beer, whole wheat, rye, plums, dates, berries, peaches, apples, olive oil, sage, thyme, oregano,nut , vinegar and corn. They must be organic because the BT Toxin in GMOs will make the body produce histamines.

https://www.sciencedirect.com/science/article/pii/S0014299915300716?via%3Dihub

https://www.medicalnewstoday.com/articles/319510.php

I find it interesting that GMOs kill the gut bacteria that help with Serotonin production and many with mastocytosis have low serotonin levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795418/

This is MTHFR and histamines. Genes that cause issues usually don’t present unless there are other health problems. Addressing them will usually correct the problems then take action to support the offending genes. If you read my post on “It is not your genes it is your gut microbiome” you will see many things that are supposedly gene mutation are actually a lack of gut bacteria that modulate those genes.

https://www.drbenlynch.com/resource/dr-lynch-interview-mthfr-overmethylation-histamine-asthma/

https://www.samanthagilbert.com/histamine-mast-cell-disorder-or-methylation-imbalance/

https://www.mthfrsupport.com.au/hnmt-cofactors-and-inhibitors/

http://alisonvickery.com.au/a-list-of-bio-individual-histamine-inhibitors/

https://metabolichealing.com/lifting-methylation-cycle-blocks-using-individual-nutrient-therapies/

https://www.geneticlifehacks.com/notes-about-histamine-and-mast-cells/

http://mthfrliving.com/health-conditions/mast-cell-activation-disorder-histamine-intolerance/

Histamine degrading enzymes and their cofactors.

https://www.mthfrsupport.com.au/histadelia-vs-histapenia/

Histone inhibitors may stop gene expression that may be causing mast cell activation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210916/

Falcarinol a cannabioid found in carrots, celery and other plants that are related reduces allergies.

http://geneticgenie.org/blog/2013/01/31/mast-cell-activation-disorder-mcad-chronic-illness-and-its-role-in-methylation/

https://www.ncbi.nlm.nih.gov/pubmed/20206138

Strategies to reduce run away mast cells.

http://goodbyelyme.com/stopping_mast_cell_inflammation

https://www.prohealth.com/library/study-shows-that-mast-cell-activation-a-disorder-common-in-lyme-disease-causes-depression-5478

Quercetin reduces mast cell activation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576204/

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033805

Because our food has been found to contain glyphosate we should avoid GMO and foods that contain it. Try our best to eat organic.

https://www.researchgate.net/publication/305318376_Glyphosate_pathways_to_modern_diseases_V_Amino_acid_analogue_of_glycine_in_diverse_proteins

When H Pylori is commensal it protects us from allergies.

https://m.jci.org/articles/view/45041

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548235/

Rehmannia reduces mast cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331951/

If we do not address histamines and inflammation it can lead to autism.

https://karmayogadaily.com/2017/04/15/groundbreaking-research-autism-histamine-inflammation-mast-cell-activation/

https://sites.google.com/site/fansofdrtheo/finding-dr-theo

When we have an infection histamine levels go up so getting the pathogen load down is very important.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938197/

High homocysteine can increase inflammation which can raise histamines.

https://www.nature.com/articles/ajg2005155

Raised histamines leads to arthritis.

http://www.jimmunol.org/content/174/12/7665.long

Raised histamines can cause adrenal fatigue.

https://www.drlam.com/blog/histamine-levels/5906/

purslane reduces histamines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316266/

Things that increase DAO to decrease histamines. Some are high sulfur foods and if you have high sulfite levels , CBS, or BH4 and have not addressed it you will make yourself worse.

https://healinghistamine.com/how-to-naturally-boost-production-of-the-histamine-degrading-dao-enzyme/

Naturals for reducing histamines.

https://www.healthline.com/health/allergies/best-natural-antihistamines#3

https://www.secondopinionphysician.com/treat-elevated-histamine/

Food additives increase inflammation and histamines.

https://www.peertechz.com/articles/immunomodulatory-effects-of-food-additives.pdf

High histamines contribute to Chronic Fatigue and fibromyalgia

https://www.ncbi.nlm.nih.gov/pubmed/29223146

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767394/

Vaccinations and GMOs cause leaky gut which causes high histamines.

https://healinghistamine.com/leaky-gut-the-mast-cell-histamine-crohns-disease-connection/

We cannot reduce oxalate entirely but would should reduce them. Most oxalates are formed inside the body so it is best to correct the problem causing them. Also leaky gut will leave oxalates enter the body.

https://healinghistamine.com/low-oxalate-low-histamine-diet-the-missing-link/

Reducing mast cells helps with diabetes and obesity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318912/

There is a lung list of illnesses caused by mast cell activation from fibromyalgia to interstitial cystitis. Mast cells release trypase and it has been found to be high in interstitial cystitis indicating that mast cell activation is and issue in interstitial cystitis.

http://www.mastcellaware.com/mast-cells/related-conditions.html

http://erj.ersjournals.com/content/29/5/861

https://www.jurology.com/article/S0022-5347(01)61915-3/fulltext

Those with mast cell activation do not always develop skin problems which is often used to diagnose it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715414/

https://tmsforacure.org/tests/

Drugs for mast cell activation. Drugs treat the symptoms so I would work on the cause while you hold the symptoms at bay.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4903110/

Mast Cell Activation increases our risk of cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710302/

High IgE levels and high mast cell activation do not always coincide with each other.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782795/

I put three drops of tea tree oil in 8 ounces of jojoba oil it helped me skin inflammation and rashes a lot.

https://www.ncbi.nlm.nih.gov/pubmed/?term=12452873

Hydroxyurea helps with mast cell activation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851743/

Food sensitivities and mast cells.

https://naturalnutmeg.com/when-food-sensitivities-take-over-the-mast-cell-connection/

Mast cells can protect the nerves or damage them. That is why homeostasis is important.

https://aacijournal.biomedcentral.com/articles/10.1186/1710-1492-1-2-65

Vitamin E which is high in olive oil and fish oil stabilizes mast cells.

https://www.wellnessresources.com/news/tocotrienols-stabilize-mast-cells

Vitamin D3 helps reduce mast cell activation but in doses higher then 4000 IU it can cause oxalates to form. That is why life guards have the highest incidence of kidney stones because our bodies make vitamin D when sun light hits our skin.

http://www.sciencedomain.org/abstract/687

Honeysuckle has many benefits including reducing allergies.

https://www.hindawi.com/journals/ecam/2015/905063/

Mast cell activation can cause high IL 17 levels which can cause Lupus and COPD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353957/

Mast cells can be an indicator of toxins.

http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-37092015000100006

Mercury and mast cells cause brain deterioration.

https://link.springer.com/article/10.1007/s11064-015-1790-z

A disruption in the endocanabinoid system can cause allergies. But there is a big scam people believe that cannibus is the only source of cannabinoids and that is not true many plants have them and each has it’s own unique benefits. Big corporations own the cannabinoid crops though so you will not hear about the other cannabinoids that often times have more healing benefits.

https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(09)00107-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0165614709001072%3Fshowall%3Dtrue

Histamine Deficiency

We have to cover both side of the coin. Histamine deficiency can also cause health problems. It is why once we achieve homeostasis we should work towards maintaining it and not continue with the protocols that may inhibit it. We could cause other health problems by pushing things in the opposite direction.

This site give the symptoms of histapenia, it mentions to take folic acid. Do not take it, it is man made and damages the body. Folate is natural and does not harm the body, I do not know why but many medical professionals do not know the difference between folate and folic acid.

Any ways the symptoms of low histamine levels are inhibited immune system, elevated serotonin, elevated dopamine, elevated norepinehrine, and low histamine. Low basophil levels, food senstivities which is not the same as food allergies, difficulty digesting food, anxiety, low libido, becoming obssesed with things, paranoia, auditory hallucination, hyperactivity, delusions of grandeur, excessive sleepiness. It can be caused by overmethylation. With low histamines the nose can be dry and you may get nose bleeds.

http://www.digitalnaturopath.com/cond/C376401.html

https://custommedicine.com.au/health-articles/histapenia-over-methylation/

http://info.healthrecovery.com/hrc-blog/a-closer-look-at-a-low-histamine-histapenia-biochemistry

https://www.everywomanover29.com/blog/methylation-and-anxiety-histadelia-and-histapenia/

https://www.aafp.org/afp/2009/0301/p391.html

Histamines help prevent cancer, inhibiting histamines can make us more prone to cancer.

https://www.nature.com/articles/nm.2278

https://www.nature.com/articles/cddis2015378

https://www.tandfonline.com/doi/full/10.1080/2162402X.2015.1047581

Autophagy is how the body recycles chromosomes. When we are deficient in histamine it can damage the heart by inhibiting autophagy.

https://www.nature.com/articles/s41419-018-0723-6

https://www.ncbi.nlm.nih.gov/pubmed/26278136

H2 inhibitors cause vitamin B12 deficiency.

https://jamanetwork.com/journals/jama/fullarticle/1788456

This is an article on decreasing histamines but talks about things that raise histamines so could be used to figure out how to raise histamine levels.

https://www.secondopinionphysician.com/treat-elevated-histamine/

https://blog.bulletproof.com/why-yogurt-and-probiotics-make-you-fat-and-foggy/

http://healthyeating.sfgate.com/foods-histamines-tyramines-1208.html

Narcolepsy

Narcolepsy is in it’s own class it alternates between high and low histamine. Narcolepsy has low orexin levels which cause this.

https://healinghistamine.com/histamine-wakefulness-sleep/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1279673/

https://www.jci.org/articles/view/71017

Increasing orexin helps with narcolepsy.

https://www.selfhacked.com/blog/how-to-increase-orexin-and-decrease-fatigue-naturally/

https://www.narcolepsysupport.org/forums/topic/how-to-increase-orexin/

https://www.wikihow.com/Increase-Orexin

High sulfite levels can cause mast cell degranulation which results in high histamines. Gut dysbiosis, candida, endotoxins, mercury, glyphosate or anything else that inhibits sulfation can cause high sulfite levels.

https://www.annallergy.org/article/S1081-1206(10)63549-1/pdf

You can see histamines could be a sign of autoimmune disorder. These link explains some basics on histamines.

https://healinghistamine.com/reacting-to-everything-this-could-be-why

https://articles.mercola.com/sites/articles/archive/2017/01/25/is-histamine-to-blame-for-headache-hives-heartburn.aspx

Autism shows the same markers as an autoimmune disorder. Vaccinations cause autoimmune disorders and many people are compensated for it from the vaccine injury compensation fund.

https://openheartedrebel.com/2017/04/15/groundbreaking-research-autism-histamine-inflammation-mast-cell-activation

Tick born illness, fungul infections and mycoplasma which most vaccinations have been found to be contaminated with can cause high histamines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938197

Metabolic issues can cause induce asthma by raising histamines.

https://seekinghealth.org/resource/exercise-induced-asthtm

Healing Interstitial Cystitis.

Written by Lee Stevenson, sorry I am not a very good editor.

I still have a lot of things to ad but I have decided to put all the research I did when I was working on healing on one web page. Hope it helps.

This is not medical advice and should not be taken as such. It is for informational and educational purposes only. Please find a qualified naturopathic doctor with a proven history of good work. Allopathic medicine only treats the symptoms, naturopathic treats the cause. For reasons I don’t have time to discuss I do not like homeopathy although it does have some good things.

It takes a lot of research and self discipline to get into remission from interstitial cystitis but I know it can be done because I can eat and do many things now. When I do have flare ups they do not last more then a day or two. For the most part the things that help me have become a habit and a part of my life so I forget I have it sometimes unless I eat some GMOs or a lot of sugar or something else I shouldn’t be eating.

Excess Oxidative stress leads to chronic illness there is a test to see if you have excess oxidative stress. If you do not get it resolved you cannot heal. You can get a test to check oxidative stress levels.

https://www.ichelp.org/oxidative-damage-may-give-clues-to-icbps-diagnosis/

There are other test that can help identify which areas of the anti-oxidant system are working and which may not be working. This can help identify the sources of high ROS levels or other toxins produced in the body from oxidative stress.

https://drjockers.com/oxidative-stress-test/

https://www.sciencedirect.com/science/article/pii/S0009898103004534

If you have bladder issues and are not certain what the problem is this is a pdf you can download that is a symptom profile for interstitial cystitis.

https://www.mdedge.com/jfponline/article/64347/womens-health/when-suspect-interstitial-cystitis

Interstitial Cystitis can be put in remission. There are many causes like toxins in our environment, pathogens. Mine is caused by Lyme disease. There are studies that have shown that up to 80% of those with interstitial cystitis have tick born illness. Vaccine injury is also a cause of interstitial cystitis. BT Toxins in GMOs and the glyphosate used on them can cause interstitial cystitis. I will try to list links to sources to show the claims I make. These links list the possible causes. When we get an infection in the bladder it sheds and raises histamines and inflammation. This tell the body there is a problem and it will send an all out attack to try and get rid of pathogens or whatever is causing the problem. In those with interstitial cystitis the bladder get stuck in this cycle and the key is getting the inflammation down and getting the brain to believe that things are ok. That is why it is very important to address mental issues, health issues and reduce the inflammation, histamines and pain so the cycle can be stopped.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908978/

https://lymemd.blogspot.com/2009/06/interstital-cystitis-and-lyme.html?m=1

GP51 glycoprotein has been found to be deficient in those with IC. This causes the bladder to get stuck in a shedding and repair state. I have found adding source of glycoprotein to my diet helped me a lot. I did herx at first because glycoproteins also help kill pathogens.

https://www.ncbi.nlm.nih.gov/pubmed/10332435

https://tasteforlife.com/retail-partners/health-guide-conditions/interstitial-cystitis

https://www.frontiersin.org/articles/10.3389/fnins.2012.00114/full

https://www.ic-network.com/lyme-disease-interstitial-cystitis/

https://www.ncbi.nlm.nih.gov/pubmed/22310775

https://www.voiceamerica.com/episode/60968/is-there-a-connection-between-interstitial-cystitis-and-lyme-disease

Each persons IC is unique and has to be addressed according to their health issues. There is no a one size fits all protocol.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798639/

I will list things that have helped my friends and I at the end of this article.

Each of us is unique we have to figure out the cause. Many of us have metabolic issues like inhibited sulfation or upregulated CBS or BH4 pathways which causes interstitial cystitis. All this can be caused by toxins, endotoxins from infection and the toxins in vaccinations which stay in the body for years. The key to going into remission is figuring out what our metabolic and immune issues are and addressing them. Many of the things I mentioned cause leaky gut so it must be healed. All the things I mentioned above cause high oxalate levels so we must watch our oxalate intake. Also high doses of vitamin C and vitamin D can cause oxalates so we must do those in moderation. Most recommend we do not do over 4000 IU of vitamin D a day. Because our skin can make vitamin D from sun light life guards have the highest incidence of kidney stones. Sun light is good and needed but do not over do it.

That being said I am going to list sites of people who have gotten their IC into remission. The reason I say remission many I know who have recovered still have temporary short term episodes but because we have learned how to recover they do not last long. So I believe we never fully get rid of IC.

http://www.icsuccessonline.com/Bill.htm

http://ezinearticles.com/?Interstitial-Cystitis—Ayurvedic-Herbal-Treatment&id=8161824

Many of the things in this article helped me but you must make sure they are organic. There are many herbicide and pesticide residues on and in foods now and they will make us much worse. To learn more read my post on GMOs.

https://naturallyhealthynews.com/articles/healtharticles/understand-interstitial-cystitis/#comment-15991

Many articles will mention cranberry but most IC sufferers have high oxalates and we must try our best to consume low oxalate foods. D-Mannose in cranberries does help the bladder and you can buy it as a separate supplement. I do not recommend cranberry juice for any bladder issues because of it’s oxalate content. Also it has a high acid level and many IC sufferers have acidosis. The things mentioned in the article below have helped many but they do promote cranberry juice which could cause problems in the bladder. When you see articles that mention cranberry juice take it with a grain of salt.

https://hubpages.com/health/Interstitial-Cystitis-Life-Without-Pain

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1476005/

Here is a list of the oxalate content of food. Remember we cannot completely avoid them but this knowledge can help us to avoid them.

http://www.wakehealth.edu/Urology/Kidney-Stones/Oxalate-Content-of-Foods.htm

This is a list of links to research of things that help with IC.

https://www.ichelp.org/research/literature-reviews/basic-research/

Diet changes that may help with IC.

http://www.todaysdietitian.com/newarchives/020314p34.shtml#.VzBtd2Pa_P0.facebook

Those who have IC usually also have fibromyalgia, the mechanisms that trigger it are the same.

https://www.ncbi.nlm.nih.gov/pubmed/9201654

https://www.ncbi.nlm.nih.gov/pubmed/17462477

All who have interstitial cystitis have mast cell activation issues. Which is also common in fibromyalgia.

https://palmitoylethanolamide4pain.com/about-2/cystitis-natural-treatment/5550-2/

https://www.ncbi.nlm.nih.gov/pubmed/26763911

https://www.ncbi.nlm.nih.gov/pubmed/9915421

Some have had good results at lowering histamines with Pentosanpolysulfate but you have to make sure you do not have sulfation issues before using it.

https://www.ncbi.nlm.nih.gov/pubmed/11061939

Studies have found that those with interstitial cystitis have an imbalance in their gut bacteria.

https://www.nature.com/articles/srep26083

Hydrangea root helps with TH17 imbalance which is common in those with interstitial cystitis and psoriasis.

https://www.medicalnewstoday.com/articles/152822.php

Bradykinins contribute to IC, grape seed extract reduces bradykinins.

https://www.ncbi.nlm.nih.gov/pubmed/10379755

Studies have shown many IC sufferers are low in vitamin D. I would not take over 4000 IU of vitamin D because studies have shown doses higher then that cause oxalates to form. Also make sure you use natural vitamin D man made vitamin D has been found to cause many negative side effects.

http://www.sciencedomain.org/abstract/687

Many of the species of bacteria that cause IC cannot be detected. These types are usually found in rivers and lakes. If our Acidophilus bacteria is low we lose the protection they give. Antibiotics kill our good bacteria which would make us lose protection.

https://www.sciencedirect.com/science/article/pii/S0022534701682375

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126088/

Vaccinations damage the HPA which is found to be common in IC.

https://www.jurology.com/article/S0022-5347(05)61144-5/abstract?cc=y

Many have said the supplement CystoProtek has helped them.

https://www.ncbi.nlm.nih.gov/pubmed/19046494

Epigallocatechon Gallate helps with IC unfortunately many of the foods that contain them are also high oxalate or high histamine. Green Tea if consumed in high quantities can raise histamine levels. Also get organic and from countries that have strict environmental laws. Tea from China has been found to be high in heavy metals and cadmium. Their are many pesticides and herbicides found on non organic teas.

https://www.ncbi.nlm.nih.gov/pubmed/23260235

Sources of EPCG, I got mine from nuts like walnuts and hickory nuts and beans especially legumes like peas.

http://ampkactivator.net/epigallocatechin-gallate/

Green tea can be hepatotoxic if consumed in high amounts. So moderation is the key with green tea.

https://www.sciencedirect.com/science/article/pii/S0273230018300928?via%3Dihub

https://www.nutraingredients.com/Article/2018/04/19/EGCG-warning-EFSA-safety-assessment-suggests-green-tea-supplements-should-come-with-warning

Leaky gut, toxins especially aluminum in vaccines, fluoroquinolones, glyphosate and glufosinsate can cause glycosylation issues. This has been found to be a problem in IC.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1464-410X.2008.08163.x

Vaccinations, tick born illness and toxins like fluroquinolones, fluoride, lead and mercury can raise substance P levels. The symptoms are burning in the skin, especially in the scalp area and down the spine. Burning or tingling nerves. Substance P increases at night so symptoms get worse at night. If levels get too high it can cause the body to start attacking itself. Feverfew, chamomille, daisy and baking soda lower substance P.

https://onlinelibrary.wiley.com/doi/full/10.1046/j.1464-410X.1998.00507.x

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1886652/

Mycoplasmas are hard to detect and can cause problems. Up to 80% of vaccinations are believed to be contaminated with mycoplasmas.

https://drfredlim.blogspot.com/p/viewpoint-on-ureaplasma-mycoplasma.html?m=1

I know it is hard to get over the trauma of our past and things that may have happened through our life. But studies have shown trauma can cause interstitial cystitis. It is very important to let negative things that have happened in our lives make us stronger. If not then the one who caused the trauma still has control by mentally victimizing us over and over again in our minds. We need to take that back and not give anyone that kind of power.

https://www.ncbi.nlm.nih.gov/pubmed/19863855

https://www.ncbi.nlm.nih.gov/pubmed/28107899

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067184/

When you have gotten all things addressed the histamines, mast cells, metabolic issues , inflammation and high substance P levels and learned to deal with stress and past trauma and the IC is still present then the brain is stuck in the shed and repair cycle. This can be caused by the pain in the bladder it signals the brain something is wrong. Many have had success with botulin toxin. It numbs the bladder for a while giving the brain time to reset. Some IC can be caused by spinal cord injury. This may help with that also.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963834/

https://www.ncbi.nlm.nih.gov/pubmed/27249005

http://www.icawareness.org/ic-awareness-month-daily-fact-22-interstitial-cystitis-and-botox

Cox is over expressed in those with IC. Natural COX inhibitors help reduce the severity of IC it is also a common cause of leaky gut and is why many with IC have digestive issues. Inflammation also causes over expression of COX.

https://www.ncbi.nlm.nih.gov/pubmed/26057882

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461170/

APF was found to be high in those with IC. I research this and found that lacking certain commensal bacteria ,inflammation and high histamines caused this. By using a suppository made of coconut oil with the strain of bacteria needed many found relief. It is also why many with IC have vulvadynia. Oxalates also will cause vulvadynia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC511055/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708545/

http://europepmc.org/articles/PMC1939966

mTOR is usually high in chronic illness. They have found that reducing mTOR helps alleviate the symptoms of interstitial cystitis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084610/

How to inhibit mTOR.

https://www.selfhacked.com/blog/mtor-natural-mtor-inhibitors/

This study showed that real life experiences where more accurate then clinical research on finding effective treatments.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783700/

https://www.hindawi.com/journals/crim/2014/698758/

Many have had good result with cannabinoids but with the metabolic issues I have it made me worse.

https://www.researchgate.net/publication/260374234_Evaluation_of_selective_cannabinoid_CB1_and_CB2_receptor_agonists_in_a_mouse_model_of_lipopolysaccharide-induced_interstitial_cystitis?utm_source=facebook&utm_medium=rgShare&utm_campaign=shareFullTextPublication

High adrenaline levels can be caused by many toxins especially GMOs and the toxins used on them. This can result in IC.

https://onlinelibrary.wiley.com/doi/abs/10.1002/nau.22542

This is a study of the many issues that can effect the bladder. It also shows why so many are effected differently and each has a variety of different symptoms.

https://www.hindawi.com/journals/bmri/2014/297295/

Environmental factors determine who will be prone to IC more then genetics.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442798/

Many who have IC have been found to be deficient in Cathelicidin. This is why vitamin D helps with IC. For those who are not converting their vitamin D to D3 you may want to supplement with D3 instead.

https://academic.oup.com/jid/article/211/7/1164/2910517

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659525/

Cathelicidin deficiency inhibits our ability to fight pathogens. GMOs, fluoride,fluoroquinolones,mercury, lead, aluminum,glyphosate and glufosinsate inhibit our ability to convert vitamin D which would result in an inability to fight infection. Those who have high levels of these substances may benefit from taking vitamin D3.

https://www.hindawi.com/journals/jir/2018/7357162/

https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-5-575

Butyrate found in butter and ghee and produced when we eat inulin (hard to digest fiber) increases Cathelicidin.

http://iai.asm.org/content/85/3/e00905-16.full

If you do not get inflammation addressed then your ability to make Cathelicidin will be inhibited no matter what your vitamin D status is.

https://www.karger.com/Article/FullText/339149

If the ability to produce Cathelicidin is not inhibited and you are producing too much Cathelicidin then you can develop thrombosis (blood clotting) and will develop more inflammation. Homeostasis is the goal. Do not over do things.

https://www.nature.com/articles/s41467-018-03925-2

TH2 cytokines down regulate Cathelicidin so if you are TH2 dominant you will be deficient in Cathelicidin. This can cause skin issues to develop. So balancing our T cells is important.

http://www.jimmunol.org/content/jimmunol/181/6/3915.full.pdf

Vaccine injury can raise zonulin levels, leaky gut caused by GMOs and toxins can also raise zonulin levels which can lead to IC. Also antibiotics and glyphosate can kill our good gut and bladder bacteria which regulates our tight junction protein layers which leads to IC. So in other words modern processed food can lead to IC. To find out more on GMOs look at my post on them.

https://www.verywellhealth.com/ibs-and-interstitial-cystitispainful-bladder-syndrome-1945197

https://www.ncbi.nlm.nih.gov/pubmed/24662556

Chemicals especially farm chemicals on our food, drugs especially fluorquinolones and many toxins can cause inflammation in the bladder which causes endothelin-1 over expression. This can lead to interstitial cystitis. If you look at IC research many of the things found in our foods and given as medication is used to cause ischemia-reperfusion in lab animals. This causes blood flow in the bladder to be disrupted which leads to IC. Endothelin-A agonist helps reduce the severity but it will not get rid of the problem. It is not mentioned in this study but Endothelin-A is a protein in a family that encodes histone acetyltransferases (HATS) and plays an important role in chromatin remodeling which is involved in DNA remodling and cell apoptosis (death) . Histones play a role in cell cycle progression and development. It controls endothelial growth. Over expression of ET-A increases inflammation. Withaferin A decreases ET-1 which may help with the inflammation and over expression of ET-1. Resveratrol found in grapes skins, grape seed extract and wine reduces ET-1.

http://europepmc.org/abstract/med/12187271

https://www.ncbi.nlm.nih.gov/pubmed/25777483

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002015000100106&lng=en&nrm=iso&tlng=en

When chemical induced ischemia-reperfusion has occurred the estrogen and nicotinic pathways work together to reduce inflammation. 17-B-Estradiol and a nicotinic agonist help reduce inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189612/

Glyphosate, glufosinate, vaccine adjuvants, and heavy metals like mercury and lead can cause damge to the NMDA receptor. This has been found to be common in those with IC. I do not like this study because instead of addressing the cause they want to treat the symptoms which seems to be the main them of allopathic medicine. If I get a chance I will do a post on things that help repair the NMDA receptor. Mugwort, olive oil, CoQ10, P5P, and coconut oil have been found to help.

http://inter-use.com/Journals/JSAB/2015/Volume_03_Issue_04/2015/0507/96.html

Some have found that the administration of GAGs have given them temporary relief from IC.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772357/

PI3K and mTor are over expressed in IC. Reducing their expression helps with inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084610/

This is a very good site for information on mTor and how to reduce it.

https://www.selfhacked.com/blog/mtor-natural-mtor-inhibitors/

Milk should be avoided it stimulates mtor.

https://nutritionfacts.org/2016/01/05/how-to-suppress-the-aging-enzyme-tor/

https://articles.mercola.com/sites/articles/archive/2016/05/07/too-much-protein-triggers-aging-cancer.aspx

IC can be mistaken for cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270612/

Thymoquinone found in many spices helps with IC.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971733/

Melatonin helps with IC. Many with Ic have been found to be deficient in melatonin which can be caused by vaccine injury, toxins and even EMFs.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-079X.2004.00202.x

Take some of the articles with a grain of salt each of us is different and each of us has foods we have to avoid which is unique to us and our metabolic and digestive issues. I believe the first article is the best I have found it to be the most accurate.

https://i-dream-of-sleep.com/increase-melatonin-production-naturally/

https://lifespa.com/10-ways-boost-melatonin-naturally/

http://www.naturallivingideas.com/boost-melatonin/

PARP inhibition helps with toxin induced bladder injury.

http://journals.sagepub.com/doi/abs/10.3181/0706-RM-151?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Querciten and Rutin are inhibitors of PARP

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896521/

Heme Oxygenase 1 expression helps reduce the symptoms of IC.

https://www.ncbi.nlm.nih.gov/pubmed/17979934

Sunlight increases Heme Oxygenase.

https://www.tandfonline.com/doi/abs/10.1080/10715769900300901

Hypoxia increase Heme Oxygenase. This can be accomplished by breathing into a paper lunch bag but if done incorrect could deprive you of too much oxygen and make you pass out. Do research if you try something like that to see how it can be done safely.

https://www.physiology.org/doi/abs/10.1152/ajpcell.2000.278.1.C92?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

Exercise stimulates HO-1

https://www.hindawi.com/journals/bmri/2018/7212861/

 

New stuff

Lipoxygenase Inhibitors along with Cox inhibitors. helps with IC that has been induce by toxins or drugs.

https://www.ncbi.nlm.nih.gov/pubmed/12686867

L-arginine improves bladder control for those who have issues with frequent urination. L-arginine increases NO so those who do not have this problems but have high reactive oxygen species this may make them worse.

https://www.karger.com/Article/Abstract/96931

A deficiency in PIRT causes excess bladder voiding.

https://www.nature.com/articles/ncomms8650

Some have to retrain their bladders once the inflammation and other issues have been addressed.

https://www.health.harvard.edu/healthbeat/training-your-bladder

Infection and metabolic issues can cause raised ammonia levels throughout the body and cause a break down of many things. Since the body gets rid of ammonia through the bladder it causes damage to the bladder. The infection or metabolic issue must be addressed.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546155/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057615/

Toxins like glufonisate and glyphosate used on our crops can cause high ammonia levels which damages many areas of the body especially the nerves which has been link to IC.

https://www.tandfonline.com/doi/abs/10.3109/15563650.2010.539184

The high ammonia levels will cause raised glutamine levels which will give you headaches especially when you consume foods that are high in glutamine. If you are having issues consuming things that contain glutamine you most likely have high glufonisate or glyphosate levels which comes mainly from eating GMOs and foods that have been dried using those toxins.

https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.21357

I eat honey because it is high in zinc and zinc reduces inflammation and ammonia levels.

https://www.ncbi.nlm.nih.gov/pubmed/18054190

Our bladders are supposed to be acidic. Infection can make them alkaline which kills our good bacteria.

https://www.jstage.jst.go.jp/article/jjaam/23/9/23_398/_article

Zinc and Carnosine work together.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852723/

Carnosine also reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745351/

Infections especially tick born illness can raise ammonia and quinolinic acid.

https://www.longecity.org/forum/topic/87433-quinolinic-acids-relationship-with-lyme-neurodegenerative-and-infammatory-disorders/

Oxidative stress and hyperammonemia can deplete pirt. This causes and over expression of P2X3 which will cause an over active bladder resulting in frequent urination.

https://www.nature.com/articles/ncomms8650

https://www.jstage.jst.go.jp/article/jjaam/23/9/23_398/_article

They are experimenting now with things that reduce P2X3 over expression.

https://pdfs.semanticscholar.org/2b41/b7cf86d99384d18eb95963efa96d9fde75d7.pdf

Antibiotic use is killing our good gut bacteria and may be contributing to the rise in the number of IC cases.

https://www.ic-network.com/dipp-mystery-ic-patients-deficient-bacteria-gut/

Acacia gum helped heal my gut. When we have digestive issues it can cause IC by raising histamines and inflammation in the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763258/

Magnesium Citrate helped me a lot. Magnesium helps reduce inflammation. I used magnesium citrate because it also reduces oxalates. The firs couple of days I took it, it gave me indigestion but the third day I started feeling much better and could not believe how much it reduced my pain. Magnesium citrate should not use often. Our bodies recycle citrate so it can build up in the body. If levels get to high then it can damage the liver , kidneys and red blood cells. Use it in moderation.

http://www.drbriffa.com/2012/04/27/the-natural-remedy-thats-often-effective-for-calming-an-irritable-bladder/

Histamines have been found to be high in those with IC and it is why so many with IC may have mental issues.

https://healinghistamine.com/the-histamine-mast-cell-depression-link/

Melatonin reduces mast cells.

https://healinghistamine.com/melatonin-mast-cells-and-histamine/

Tocotrienols a type of vitmaine E found in palm oil, rice bran oil, wheat germ, barley, saw palmetto and oats lower histamines and substance P. You have to be careful some of those are GMOs and the BT Toxins from GMOs have been found in mothers fetuses and human brains and causes the same symptoms as food poisoning.

https://www.wellnessresources.com/studies/tocotrienol-allergic-dermatitis

Catalase helps restore the antioxident system back to homeostasis but many things that contain it are high sulfur so make sure you do not have sulfation issues. Eating high sulfur foods and meat when you have sulfation issues will make you worse if you do not address it.

http://healthyeating.sfgate.com/vegetarian-sources-catalase-3693.html

Vitamin A deficiency can cause IC

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786935/

Food sources of vitamin A. Always try to get your vitamins from natural sources, many vitamins are synthetic and have been shown to have many side effects especially folic acid it causes cancer and damages the NMDA receptor. Folate which is natural does the opposite.

https://www.globalhealingcenter.com/natural-health/vitamin-e-foods/?gclid=EAIaIQobChMIt9T3p5Le2wIVFVqGCh22_wbNEAAYAyAAEgLu4fD_BwE

https://www.dietitians.ca/Your-Health/Nutrition-A-Z/Vitamins/Food-Sources-of-Vitamin-A.aspx

https://healthwholeness.com/vitamin-rich-foods/vitamin-a-foods

Cat’s Claw helped me. Phytoestrogen has been shown to reduce IC symptoms. Cat’s Claw contains Phytoestrogen is most likely why it helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496084/

Some have said honey bush tea has helped them.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817056/

phytoestrogens are why Peuraria Mirifica and Maca root reduce symptoms of IC.

https://www.ncbi.nlm.nih.gov/pubmed/17415017

Malva is in the mallow family. Most plants in the Mallow family reduce inflammation and help heal the gut and tight junction protein layers in the gut and bladder. I grow the cheese plant which is in the mallow family and has the same benefits as marshmallow root.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590556/

Toxins, vaccine injury, GMOs and stress can increase glutamate levels which can make IC worse. Plants that helped calm me like honeysuckle, yarrow, opium lettuce and wild daisy really helped me a lot.

https://www.ncbi.nlm.nih.gov/pubmed/26697981

Tick born illness and mycoplasma inhibit IL 10, Our bodies use IL 10 to detect infections and rid the body of them. Then it will reduce inflammation. Inhibiting IL 10 causes excess inflammation. This cause the body to be unable to recognize the pathogen. When this happens the body will release hydrogen pyroxide which is a last ditch effect to remove the pathogens from the body. This cause a lot of damage throughout the body. This is why it is important to reduce inflammation and to support the function of IL 10. Hydrogen pyroxide will break down the tight junction layers in the gut, blood brain barrier and bladder. This cause inflammation in all those areas. When the tight junction layer has been effected in the digestive system food allergies and intolerances will develop. Warning increasing IL 10 can lead to weight loss.

http://www.jimmunol.org/content/188/2/781.full

https://www.ncbi.nlm.nih.gov/pubmed/16375698

https://www.selfhacked.com/blog/il-10/

Blocking Tumor Necrosis Factor will upregulate IL 10

https://www.frontiersin.org/articles/10.3389/fimmu.2017.00157/full

Ways to inhibit TNF , they recommend ketosis. That worked great for me but those with type 1 diabetes that can result in death.

https://www.selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/

http://www.life-enhancement.com/magazine/article/2428-pain-relief-starts-in-the-brain-blockade-of-tnf-alpha-tumor-necrosis-factor-alpha-inhibits-the-br

http://www.scielo.br/pdf/bjps/v47n3/02.pdf

Lactococcus Lactis found in some cheeses and buttermilk increase IL 10

https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-016-0548-x

Sepsis can result in IC. This is caused from being given too high of a dose of antibiotics which kills of pathogens and fungus to quickly. The body becomes overwhelmed with endotoxins or afloxin resulting in a lot of damage throughout the body.

http://www.sepsis.org/sepsis-and/urinary-tract-infections/

Methylene Blue which can be found in the urinary section at most stores and pharmacies help with sepsis but should not be taken if you are anemic or G6PD deficient. If you have high levels of glyphosate or glufonisate you can be G6PD deficient.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770994/

https://www.medicinenet.com/methylene_blue-oral/article.htm

This site has a list of the various forms of Methylene Blue so you will know what to look for on the package.

https://www.goodrx.com/methylene-blue/what-is

Atropine also helps with sepsis and has the added benefit of detoxing glufonisate, glyphosate and orthophosphates.

https://www.ncbi.nlm.nih.gov/pubmed/18369575

https://www.ncbi.nlm.nih.gov/pubmed/7621764

https://www.ncbi.nlm.nih.gov/pubmed/8415873

Moringa is good stuff it helps with just about everything.

https://www.hindawi.com/journals/isrn/2014/906843/

Proteus Mirabilis is acquire in hospitals usually from catheters and is one of the hardest to get rid of.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638163/

https://www.ncbi.nlm.nih.gov/pubmed/21921687

Epilobium helps with antibiotic resistant strains of infection. Known as willow herb.

https://www.degruyter.com/view/j/chem.2016.14.issue-1/chem-2016-0004/chem-2016-0004.xml

Willow herb also reduces inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/21112753

Helps restore antioxidant homeostasis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783546/

Calcium supplements cause urinary tract infection can also raise oxalates. That is why I get my calcium from stinging nettles. If you eat fruits and vegetables you should be getting enough calcium. Most bone lose is caused by either silica or magnesium deficiency. Calcium deficiency is rare.

https://www.ncbi.nlm.nih.gov/pubmed/2204174

https://draxe.com/stinging-nettle/

https://www.organicfacts.net/health-benefits/herbs-and-spices/stinging-nettle.html

Joe Pye also known as Gravel Root helps. It is a calcium channel blocker also though and has an alkaloid that can build up in the body so should not be used in high doses or for extended periods of time.

https://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-957558

There are toxins in feminine products that can cause IC. Organic or some alternative should be used. Cotton feminine products are from GMO cotton which contains BT Toxin which can cause many problems. This was not mentioned in the article.

https://www.thehealthyhomeeconomist.com/nontoxic-alternatives-to-tampons-and-sanitary-napkins/

I am not big on pharmaceuticals because they treat the symptoms not the cause but many of my friends have said Tempol has helped them. Please research first if you decide to try this.

https://www.karger.com/Article/FullText/430183

If you read about glyphosate you will see how it could cause IC. Glufonisate is Bayers version of glyphosate and causes the same health problems. If you read my GMO post you will see that our food is heavily contaminated.

https://people.csail.mit.edu/seneff/SamselSeneffGlyphosateIV.pdf

I seen many take metformin. They would do really good at first then get much worse so I don’t trust it. It also causes vitamin B12 deficiencies which can lead to permanent nerve damage.

http://www.diabetesincontrol.com/metformin-induced-vitamin-b12-deficiency-presenting-as-a-peripheral-neuropathy/

Things that can cause frequent urination at night.

https://www.healthline.com/health/overactive-bladder/overactive-bladder-night#causes

https://www.wikihow.com/Stop-Late-Night-Bathroom-Trips

http://www.homeremediesforall.com/natural-remedies/frequent-urination-at-night.html

Many have had good results with lactoferrin. It helps the good bacteria get reestablished. It is not mentioned in the article but it chelates the bad iron from the body and builds up heme by giving the body good iron.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614382/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837981/

Lactoferrin has been found to break up biofilms and so has serrapeptase. Serrapeptase also breaks up scar tissue but can cause problems if taken in very high doses. It helped me a lot. Biofilms make many infections impervious to the immune system and even drugs.

https://www.hindawi.com/journals/ab/2014/543974/

http://www.tiredoflyme.com/biofilm.html

Biofilm busters.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648868/

https://www.selfhacked.com/blog/44-science-backed-ways-to-inhibit-biofilms-naturally-with-references/

This article mentions nattokinase. I did not use it because it has estrogen like effects. I figured boobs would not look good on a man.

https://blog.designsforhealth.com/biofilms-and-resistance

I got candida from antibiotics. I fell for the alkazing myth and things got much worse for me so I started doing the opposite. Lo and behold it started going away. Candida likes and alkaline environment and will actually switch from commensal (friendly) to a pathogen if the alkalinity of digestive system or bladder gets too alkaline. Our bladder and digestive tract is supposed to be acidic. We have bacteria that keeps our bladder and digestive system at the correct PH. If we are deficient in those bacteria then our digestive system and bladder can become alkaline promoting infection of many types of pathogens especially candida.

https://www.candidaplan.com/10-candida-myths-2/

Japanese Honeysuckle helped me a lot. It is the one with the white and yellow flowers. Most other types of honey suckle are poisonous. It reduces inflammation and has pain killing abilities. It made me sleepy but the baby does of baby benadryl does that to me.

https://www.ncbi.nlm.nih.gov/pubmed/27534446

Golden rod helped me. It kills pathogens reduces pain and inflammation. I herxed the first time I used it. This is the European Golden Rod but Solidago Canadensis found in the US has just about the same properties.

https://www.ncbi.nlm.nih.gov/pubmed/27249953

I hate to say this because I love salt but salt makes things worse. But studies have shown that if you use see salt you do not crave as much salt because it has more nutrients needed by the body.

https://www.ncbi.nlm.nih.gov/pubmed/6191542

Flavocoxid is a combination of ingredients. I took these ingredients separately on my own and they healed me so fast that all heck broke loose from my nerves and muscles waking up when my blood flow improved and my nerves woke up. I got bad muscle spasms and my nerves felt hot. After about three days though I felt great. And each day after I could actually feel it healing me. I did not know about this supplement that already had them in it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765324/

 

Even newer stuff.

If we do not get enough cholesterol we cannot heal. Cholesterol is needed by the cells to protect us from inflammation, infections, our heart , brain, liver and kidneys cannot function without it. Statins destroy brain cells in a way they cannot repair it almost petrifies them because they deprive them of cholesterol. Read my post on how high oxLDL is a symptom not a cause.

http://www.greenmedinfo.com/blog/underreported-dangers-low-cholesterol

https://chriskresser.com/why-you-should-eat-more-not-less-cholesterol/

Sculletaria heals things all through the body. I used American Sculletaria which is much more powerful. I would not recommend that because it healed me too quickly and when things started waking from the nerves healing and improved blood flow all heck broke loose for a few days.

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0682-8

I am putting this here for a note, I have not gotten to research it. Pathogens in the bladder induce Indoleamine 2.3-Dioxygenase in the bladder which inhibits immune response.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415894/

Antiphospholipid Syndrome can present in the renal system. This can be cause by tick born illness, vaccine injury or farm chimicals in food especially glyphosate.

Thuja helps with cystitis but there are better source then white cedar. Mugwort and wormwood are much better alternative sources of Thuja.

https://www.ncbi.nlm.nih.gov/pubmed/25818694

Excess lipid peroxidation can cause many problems, high oxLDL, high ammonia , inflammtion, the list goes on and on. These naturals inhibit lipid peroxidation.

https://www.ncbi.nlm.nih.gov/pubmed/17726737

Inhibiting 5-Lo reduces inflammation. Mediterranean Sage an invasive weed in the western states of the United States ihibits 5-Lo.

https://link.springer.com/article/10.1007/s000110050730

Oxeye Daisy kills pain and reduces inflammation. I seen no studies on it being a sedative but when I drink it I end up going to sleep every time.

https://www.herbal-supplement-resource.com/daisy-herb-benefits.html

Ebselen is one of the few drugs I would take it reverses sepsis, reduces oxidative stress, heals the brain and bladder and does many other things. Unfortunately they will only prescribe it to people with psychosis.

https://www.sciencedirect.com/science/article/pii/S0014579396012379

A list of foods and their oxalate levels. I noticed a few of the low oxalate were GMO which is worse if you read my page on that.

https://healinghistamine.com/low-oxalate-low-histamine-diet-the-missing-link/

I put five drops of tea tree oil in about 10 ounces of jojoba oil and it really reduced the burning and rashes on my skin. Tea tree reduces histamines and substance P. Do not consume it though.

https://www.ncbi.nlm.nih.gov/pubmed/12452873

Proteolytic enzymes helped me a lot. They have many benefits like reducing inflammation, aiding with digestion, kill parasites. They made it so I could eat.

https://draxe.com/proteolytic-enzymes/

St. Johnswort reduces pain inflammation and has antioxidant properties. I seen studies that claimed it was toxic to the liver. Those studies where vague as to methodology and lacking data. Most studies I have read on St Johnswort showed it to be non toxic and does the opposite it actually reduce inflammation in the liver.

https://www.ncbi.nlm.nih.gov/pubmed/25851311

https://www.karger.com/Article/Pdf/21265

https://draxe.com/st-johns-wort-uses/

This is a good article on reducing inflammation with food and why they work.

http://www.itmonline.org/arts/lox.htm

Antibiotics, GMOs and herbicides kill our gut bacteria. Certain gut bacteria use tryptophan to modulate our immune system. We become prone to infection if we are lacking those bacteria, especially candida infection. Consuming foods high in tryptophan helps restore them and our immune function. Our adaptive immunity comes from our gut bacteria. When we are low or deficient in certain ones we can have either an over active immune response or non at all. This also protects us from inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/29341448

https://www.sciencedirect.com/science/article/pii/S1074761313003312

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292609/

Tryptophan was found to be low in those with MCAD.

https://www.prohealth.com/library/study-shows-that-mast-cell-activation-a-disorder-common-in-lyme-disease-causes-depression-5478

Foods high in tryptophan to feed the gut bacteria. Many of the things mentioned are dried using glyphosate and glufonisate especially beans and grains so make sure you eat organic. Those destroy our good gut bacteria making us prone to many pathogens.

https://www.myfooddata.com/articles/high-tryptophan-foods.php

https://nootriment.com/tryptophan-foods/

The metabolic issues I had made it impossible for me to eat meat because of the high phenylalanine content, potatoes and other things high in phenylalanine were out also. I had to eat a vegetarian diet for a very long time until I corrected my metabolic issues. If you have sulfation issues or upregulated BH4 or CBS pathways your will develop very high ammonia levels because sulfite levels rise very high and causes you body to be unable to recycle phenylalanine. So as it is used the biproducts produced build up in the blood stream and ammonia is one of them.

https://www.veganmotivation.com/tryptophan-foods-boost-serotonin/

Though NO can cause damage in the body it is needed to maintain health. So we do not want to reduce it too low. It will cause many negative health issues if we do. That is why many develop high blood pressure when under oxidative stress because it depletes NO. Homeostasis should always be the goal.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906415/

Olive leaves are very good for fighting infection but if you have a high metabolism they are not good for you. They speed up the metabolism. Olive oil has many benefits. It activates the Nrf2/keap1 pathway which is a key part of our antioxidant system that protects our cells. If you have pyrole issues you will have gall bladder pain and/or indigestion when you consume oils. Supporting sulfation will helps with pyrole issues. Also reducing histamines and inflammation help correct issues with pyroles.

http://www.phytochemicals.info/plants/olive.php

Rehmania raises blood pressure. I have cardititis and this help get my blood pressure up which made me feel much better. I did not take it everyday though because homeostasis should always be the goal. It also reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331951/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900793/

Before I got my gut straightened out my brain was a mess. We need butyric acid but our limited diets prevent us from eating the foods that contain it like milk products and the plants that contain the fiber many of us cannot eat because of sulfation issues which many plants that contain inulin which our gut bacteria produce butyric acid from are high in sulfur. Onions are one example of that and I was so lactose intolerant that milk products were definitely out. The solution for me was to make ghee. All the lactose is removed but the butyric acid remains. It made a world of difference in my health I had more energy and could think so much clearer. Since I have my gut healed and my metabolic issues straightened out I can eat pretty much anything.

https://wholehealthsource.blogspot.com/2009/12/butyric-acid-ancient-controller-of.html?spref=fb

If you have chemical sensitivities or sensitivity to odors then you have glucuronidation issues. Calcium-D-Glucarate helps address that. I had problems with this bad. Even the candle section in stores would make me ill and even affect my bladder.

https://www.diagnose-me.com/treatment/calcium-D-glucarate.php

https://blog.bulletproof.com/calcium-d-glucarate/

If you have metabolic issues and try to change to a healthier diet it could backfire. We must take the nutrients that support those pathways. If not there will be a lot of food we will not be able to eat.

https://www.anniehelpsyou.com/blog/item/2-are-phenol-oxalate-sensitivities-causing-your-health-problems

P53 role in cystitis.

http://europepmc.org/articles/PMC1939966

This is only an abstract but it list illnesses caused by high TH17 levels. Vaccine adjuvants, many farm chemicals and heavy medals can cause high TH17 levels. Tick born illness can also if the endotoxin levels get high enough. If you notice you will see many commonalities with IC.

https://www.annualreviews.org/doi/full/10.1146/annurev-pathol-011110-130318#_i21

Antibiotics and farm chemicals kill our good gut bacteria that protects us from infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911494/

We have commensal bacteria that are related to pathogenic. When they are killed by antibiotics or farm chemicals we lose that protection and become prone to illness from the pathogenic ones. Ever notice how many will eat the same contaminated food but only some of them would get ill. They liked the commensal relatives of the pathogenic bacteria so were not protected. Unfortunately the only probiotic I found that contains the commensal E Coli strain is VSL#3 and it is very expensive.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862908/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869251/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083503/

These studies show the importance of our gut bacteria to the health of our organs throughout the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624329/

https://www.sciencedirect.com/science/article/pii/S2212877816300564

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351195/

https://www.ncbi.nlm.nih.gov/pubmed/21778036

Modern day chemicals in our food supply and antibiotics can ruin our ability to produce FUT2 enzymes. These modulate our immune system and keep our gut bacteria balanced and happy. If we are not producing FUT2 enzymes then we cannot fight infection and our gut bacteria will get out of balance and we will even become deficient in some bacteria. Many will take probiotics with not results for this very reason.

https://www.nature.com/articles/ismej201464

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516493/

If we are FUT2 deficient it indicates that we are lacking Bacteroides Thetaiotaomicron which is supposed to be one of the most numerous of the gut bacteria. If we are lacking this bacteria we will have trouble eating certain carbs and cannot break down many types of fiber.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840232/

They claim it is a genetic issues but other gut bacteria regulate FUT2 secretion

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800993/

This is a list of gut microbiotia and their effects on the digestive system and the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873327/

What complicates things is that the medical community cannot identify the difference between commensal and pathogenic. Often times they give antibiotics that kill bacteria we need. When we get an infection from a bacteria that is usually commensal it means something is out of balance in the body. Instead of looking for the problem they kill the commensal bacteria that we need.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988121/

http://mbio.asm.org/content/5/6/e01817-14.short

Getting chlamydia shows there is a deficiency in Lactobacilli which balances the ph of our bladders and digestive system. Most pathogens cannot survive in an acid ph which is what the bladder and digestive system are supposed to be.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0107758

So an imbalance in our bacteria causes us to become prone to urinary tract infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684288/

Our bacteria even protects us from respiratory infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370528/

If you notice these are receptors involved in IC. This study shows that our good bacteria regulate our gene expression. It is the bacteria we inherit from our parents that determines what illnesses we will be prone to. Not only that but the foods we eat determines which genes they turn off and on.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339702/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219689/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433529/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866888/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909826/

Here is where it can get confusing. Some strains of lactobacillus are pathogenic. We have to make sure the strains we take are ones that reduce inflammation and histamines. We need inflammation and histamines for the body to heal and repair but when there is and imbalance in our gut bacteria the strains that cause them become more numerous and histamine and inflammation levels become too high.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565189/

Germ theory has been proven wrong repeatedly yet they base their research on vaccinations on it. Our gut bacteria modulate and train our immune system. So vaccinating overrides our ability to develop immunity which means the only thing it would do is confuse the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892783/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352444/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902499/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722804/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221693/

Our gut bacteria even regulate our biological clock.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780501/

Our gut bacteria determine if we will be obese or not.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127273/

Our gut bacteria regulate our mood and emotions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987167/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987016/

An imbalance in our bacteria in our lungs can result in lung disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586181/

We even have a gut bone axis and our bone is effected by our gut bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742533/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235701/

Our gut bacteria even regulate our cholesterol levels.

https://www.ncbi.nlm.nih.gov/pubmed/29209439

This is why it is very important to get polyphenols, oligosaccharides and polysaccharides in our diets. It feeds our beneficial bacteria which promotes better health. There are myths about the sugars in foods like fruits and vegetables feeding candida when it becomes pathogenic but the opposite is true. Much of the false information out there drives me to believe that the pharmaceutical companies put it out there to keep people on a hamster wheel of poor health so they will have a steady customer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493053/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000740/

https://www.cell.com/trends/microbiology/fulltext/S0966-842X(16)30143-3

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961256/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429330/

Not only do we need to feed the good gut bacteria but our diets to manipulate our gut bacteria needs to be unique to each of us. A diverse diet gives us a diverse microbiome which protects our health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801817/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918027/

The myth I see that is the most damaging is people being told to avoid all fats. They are a necessary nutrient for good health.

https://www.ncbi.nlm.nih.gov/pubmed/28482838

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650612/

Another myth is to avoid carbohydrates. It is a good way to develop autoimmune disease. We need a variety in our diet.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857604/

I find it strange that almost all science surrounding modern medicine is being proven wrong by science that is thousands of years old.

We have commensal virome in our gut. What happens when antibiotics or farm chemicals kill them. How do we replace them and restore out health?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656937/

Our gut virome also regulate our immune system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923440/

Our gut bacteria even secret non toxic antibiotics that do not kill the good bacteria like man made antibiotics do.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586196/

This is a study on female urinary biome and health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161260/

Male urinary biome and health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990618/

If you are prone to E Coli you may be lacking the phage or virus that protects us from it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967307/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900583/

https://www.ncbi.nlm.nih.gov/pubmed/21412185

If you get tick born illness, yep lacking gut phages.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097911/

Peroxisomes secreted by our gut bacteria protect us from excess reactive oxygen species generated during oxidative stress.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0117851

This is a list of microbiota and their functions.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1574-695X.2005.00026.x

https://mentalhealthdaily.com/2016/03/01/10-best-probiotics-for-depression-anxiety-gut-brain-axis-modification

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992746/

This is a symposium on microbiome.

https://www.tandfonline.com/toc/zmeh20/current

When I ate anything including fruit I got very ill, probiotic yeast help a lot with that. It would feel like a brick was setting in my stomach after I ate. This helped me a lot. Also if I ate carbohydrates I would feel ill this corrected that also.

https://www.healio.com/gastroenterology/irritable-bowel-syndrome/news/online/{bb454dd3-01bf-4720-a01e-912c62d09062}/probiotic-yeast-improves-abdominal-pain-bloating-in-ibs-c-patients

If you have problems eating dairy these are the strains needed. I had very bad dairy issues. Some of the strains that break down dairy also break down carbohydrates.

https://www.sciencedirect.com/science/article/pii/S0023643812000503

https://www.sciencedirect.com/science/article/pii/S0963996912000890

https://pubs.acs.org/doi/abs/10.1021/acs.jafc.6b00714?journalCode=jahttp

These are the strains needed for urinary and bladder issues.

https://www.hindawi.com/journals/au/2009/680363/

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1151418

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684288/

If your microbiome imbalance persist it may be from your sexual partner.

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-016-0161-6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225992/

https://academic.oup.com/aje/article/156/12/1133/151795

These articles mention the probiotics to avoid if you have high histamines. The second link mentions the ones that reduce histamines.

http://www.low-histamine.com/tag/probiotics/

https://wholenewmom.com/health-concerns/low-histamine-probiotics/

P53 levels are found to be low in most IC cases. I did not pursue increasing this because most cancers have high levles of P53. I think it would be better to find out what is inhibiting it and correct that rather then trying to increase it.

http://europepmc.org/articles/PMC1939966

It should be clear to most now that the genetic theory of inherited imperfections causing illness is not accurate.

Wild Violet

Viola

This is not medical advice and should not be taken as such. It is for information and educational purposes. If in doubt don’t make sure you know your plant before you use them.

Their are many species of wild violet but their nutrients and phytochemistry is pretty much the same.

Viola Biflora, Viola Canina, Viola, V. Labradorica, V. Odorata, V. Rostrata, and V. Sororia are the ones I am familiar with. They all taste the same to me. I love them it is one of my favorite wild edibles. I could eat wild violets daily. They have similar nutrients as dandelion only higher levels of them.

http://www.ediblewildfood.com/wild-violet.aspx

https://thesurvivalmom.com/enjoy-wild-violets/

The viola species have hepaprotective properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217637/

They reduce inflammation and an over active immune system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918579/

Reduces coughing

https://www.ncbi.nlm.nih.gov/pubmed/25954025

Phytochemicals that are good for the heart and oxidative stress.

https://www.ncbi.nlm.nih.gov/pubmed/23035206

Reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967839/

https://www.ncbi.nlm.nih.gov/pubmed/26751970

Is nueroprotective.

https://www.ncbi.nlm.nih.gov/pubmed/27516984

Anti inflammatory.

https://www.ncbi.nlm.nih.gov/pubmed/17983197

Fights cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163403/

Fight bacterial infections.

https://www.ncbi.nlm.nih.gov/pubmed/20558471

Reduces histamines

http://www.thepab.org/files/2017/March-2017/PAB-MS-160199.pdf

https://www.sciencedirect.com/science/article/pii/S0378874113005941

Is high in mucilage which heals the gut. It is so high that when I make tinctures they come out like a gel.

https://thenaturopathicherbalist.com/herbs/v-z/viola-tricolor/

Lemon Balm

Melissa Officinalis

This is not medical advice and should not be taken as such. If in doubt don’t if you do not know a plant do not use it.

Lemon Balm is good for soothing the stomach and for relaxing. It has also been shown to be good for making a balm for herpes chancres. Improves blood sugar levels, also helps with getting restful sleep. Has been shown to protect the brain cells.

https://thenerdyfarmwife.com/12-things-to-do-with-lemon-balm/

https://www.globalhealingcenter.com/natural-health/9-benefits-of-lemon-balm/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230760/

Helps fight viruses even herpes.

https://www.ncbi.nlm.nih.gov/pubmed/24817544

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613005/

Safe to consume in large quantities.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433273/

Is good at treating and preventing oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871149/

It helps with ventricular arrhythmia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586902/

Has been shown to help with heart palpitations.

https://www.sciencedirect.com/science/article/pii/S0378874115000781?via%3Dihub

Has antimicrobial properties.

https://www.ncbi.nlm.nih.gov/pubmed/20201279

https://www.ncbi.nlm.nih.gov/pubmed/26075899

The flavonoids found in Lemon Balm along with other herbs have antidepressant properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829422/

Fights cancer

http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:26320439&key=2015.16.14.5703

Phytochemicals

https://www.ncbi.nlm.nih.gov/pubmed/26495650

Reduces premenstrual symptoms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557408/

Improves cognitive function.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1738567/

Has been shown to reduce histamines.

http://opensiuc.lib.siu.edu/cgi/viewcontent.cgi?article=1342&context=ebl

Japanese Honeysuckle

Lonicera Japanica

Janpanese honeysuckle

Many species of honeysuckle are poisonous so be careful. Japanese honeysuckle will have both white and yellow flowers. It is good for lowering blood pressure and healing the heart and blood vessels. It has relaxant qualities. It has anti inflammatory effects. The whole plant can be used.

http://www.naturalwellbeing.com/learning-center/Lonicera_Japonica_Flower/

Has been shown to be effective against respiratory tract infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765429/

Inflammation

https://www.sciencedirect.com/science/article/pii/S0009898103000172?via%3Dihub

Has been shown to be neuroprotective.

https://www.sciencedirect.com/science/article/pii/S0144861714003105?via%3Dihub

https://www.ncbi.nlm.nih.gov/pubmed/22227216

Phytochemiclas

http://mason.gmu.edu/~cscottm/plants.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923575/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1197872/

It inhibits histamines.

http://www.mdpi.com/1420-3049/19/6/8212

Helps with diabetes.https://www.readbyqxmd.com/read/28539735/pharmacognostic-specification-chlorogenic-acid-content-and-in-vitro-antioxidant-activities-of-lonicera-japonica-flowering-bud

https://www.sciencedirect.com/science/article/pii/S0367326X16300405?via%3Dihub

Fights cancer

https://www.ncbi.nlm.nih.gov/pubmed/18796326

Scavenges Nitric Oxide so would be good for the heart.

https://www.readbyqxmd.com/read/28539735/pharmacognostic-specification-chlorogenic-acid-content-and-in-vitro-antioxidant-activities-of-lonicera-japonica-flowering-bud

Appears to have no toxicity.

https://www.ncbi.nlm.nih.gov/pubmed/16697541

Feverfew

 

Tanacetum Parthenium

I  have written this for educational purposes. If in doubt don’t, make certain you know your plants. This is not medical advice and should not be taken as such.

Feverfew is another one of those herbs that have been a life saver for me and my battle with Lyme. I could not believe how much better I felt in the morning after taking it. It has been shown to reduce inflammation and fight cancer. It has been shown to reduce headaches and other types of pain. Long term use of Feverfew can result in toxic rebound withdrawal headaches. This is an herb I only use when I have the flu or a cold. It dramatically reduces the symptoms and duration of my illness.

https://www.brettelliott.com/detox-blog/feverfew-tanacetum-parthenium-herbal-monograph

https://www.ncbi.nlm.nih.gov/pubmed/21631494

https://www.ncbi.nlm.nih.gov/pubmed/26141762

Has been shown to reduce muscle spasms, histamines,cancer and has antibiotic properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210009/

Has been shown to protect the liver from damage.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615166/