Heat Shock Proteins and their effects on our health.

This is not medical advice I am posting this for educational and informational purposes.

HSP70 has it’s benefits if done in moderation. Always keep in mind homeostasis should be the goal.

HSP70 is found to be high in those with skin disorders. So those with dermititis would want to reduce HSP70

https://www.ncbi.nlm.nih.gov/pubmed/19109201

https://academic.oup.com/ps/article/91/4/790/1576718/Overexpression-of-heat-shock-protein-70-and-its?view=long&pmid=22399716

HSP70 redulates angeotensin II, it reduces inflammation in the renal system but if a person is deficient in vitamin D it could cause inflammation in the cardiovascular system.

https://www.researchgate.net/profile/Walter_Manucha/publication/264615576_HSP70_Family_in_the_Renal_Inflammatory_Response/links/53e916ff0cf2dc24b3c7eb11/HSP70-Family-in-the-Renal-Inflammatory-Response.pdf?origin=publication_detail

HSP 70 is essential for preventing salt induced hypertension.

https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14334

HSP70 helps regulate the antioxidant system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971240

HSP70 helps regulate cellular redox.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1971240

This is how selenium, vitamin C and sodium bicarbonate reduce oxidative stress by increasing HSP.

https://www.ncbi.nlm.nih.gov/pubmed/29442224

https://www.ncbi.nlm.nih.gov/pubmed/28386897

Protects from neurological disorders.

http://m.pnas.org/content/112/52/16006.full

HSP70 can prevent thrombosis (blood clotting) without causing anemia.

https://academic.oup.com/cardiovascres/article/110/3/309/1744740?searchresult=1

Increasing HSP70 also helps with liver disease cause by B-thalassemia which causes liver fibrosis.

https://journals.lww.com/co-hematology/Abstract/2016/05000/Novel_players_in___thalassemia_dyserythropoiesis.2.aspx

Good information on ways of increasing or decreasing HSP70

https://www.selfhacked.com/blog/heat-shock-proteins-hsp70-increase-decrease/

Heat shock protein protects the cells from oxidative stress so can actually protect cancer. In this case it would probably be beneficial to reduce HSP70. Homeostasis should be the goal.

https://www.ncbi.nlm.nih.gov/books/NBK6084/

http://hsp70.com/inhibitors/

https://www.nature.com/articles/4401124?cookies=accepted

Sulfation is very improtant in the regulation of HSP. If we have sulfation issues or high sulfite levels to need to be addressed for HSP to function properly. Sulfation issues also effect the Nrf2 pathways which is also responsible for HSP homeostasis. Nrf2 is the master regulator of the antioxidant system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302153/

Induction of HSP70 may help with Lou Gehrig’s disease.

https://academic.oup.com/brain/article/139/5/1417/2468726?searchresult=1

HSP70 protects the liver. They claim fructose increases HSP70 , that may be true for unprocessed fructose found in fruits and vegetables but processed fructose has been found to have a severe negative impact on health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568217/

Heat shock protein is stimulated during exercise. Heat shock protein has been shown to reduce hot flashes caused by menopause.

http://www.ufrgs.br/fisiologiacelular/site/arqs/ENSINO/artigos%20em%20PDF/Nitric%20oxide-heat%20shock%20protein%20axis%20in%20menopausal%20hot%20flushes%20(Miragem%20and%20Homem%20de%20Bittencourt%20HRU%2023(5)%20600-628,%202017).pdf

mTOR homeostasis is very important for the proper regulation of heat shock proteins.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154417/

Some infections can cause HSP instability.

http://jvi.asm.org/content/79/4/2033.full

HSP70 is responsible for cleaning up protein aggregates in the body. When inhibited it can cause health problems.

https://www.cell.com/molecular-cell/fulltext/S1097-2765(16)30365-3

http://dmm.biologists.org/content/7/4/421

HSP90 over activation can contribute to neurodegerative disease.

https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-5-24

Low HSP70 levels is associated with frail health.

https://bmcimmunol.biomedcentral.com/articles/10.1186/1471-2172-12-24

How heat shock proteins regulate cell death.

https://www.nature.com/articles/1207114

Oral HSP are used to treat autoimmune disease and cancer.

https://www.ncbi.nlm.nih.gov/pubmed/9559977

https://www.hindawi.com/journals/ad/2012/486069/

HSP70 helps reduce inflammation in diseases like IBD.

https://www.ncbi.nlm.nih.gov/pubmed/26467144

https://academic.oup.com/ps/article/91/4/790/1576718

Fasting increases HSP70

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0110748

HSP90 contributes to the ill effects of oxalates.

https://link.springer.com/article/10.1007/s00775-016-1355-x

https://www.ncbi.nlm.nih.gov/pubmed/20210657

HSP70 protect from oxalate toxicity.

https://link.springer.com/article/10.1007%2Fs00240-007-0130-4

Inhibiting HSP90 helps fight viruses.

http://jvi.asm.org/content/87/18/10126.full

HSP90 inhibitors helps fight cancer.

https://www.ncbi.nlm.nih.gov/pubmed/25912253

https://www.sciencedirect.com/science/article/pii/S0167488910002533

High HSP90 levels contribute to COPD.

http://erj.ersjournals.com/content/51/2/1700386.long

HSP70 is downregulated in fibrosis.

https://onlinelibrary.wiley.com/doi/abs/10.1002/jcb.26423

Some chemicals found in gensing inhibit HSP90

https://linkinghub.elsevier.com/retrieve/pii/S0304-3835(17)30648-1

Geranium Thunbergii inhibits HSP90

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074266

Thunder god vine inhibits hsp90

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823561/

Green tea inhibits HSP90 which helps with interstitial cystitis but if you drink too much it will increase histamine levels which would have the opposite effect.

http://www.ucmg.net/wellness/holistic_articles/nutrients/Green-tea_Natures-exlixir.htm

http://iai.asm.org/content/84/4/1176.full.pdf

Inhibiting HSP90 also helps with Lupus.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0127361

HSP90 is needed for many cellular processes so homeostasis should always be the goal.

https://www.ncbi.nlm.nih.gov/pubmed/23806880

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004347/