Written by Lee Stevenson, sorry I am a lousy editor.
This is not medical advice I am writing this for educational purposes. If you are ill please seek the aid of a qualified and experienced functional medicine practitioner.
Calcium-D-gluturate
Calcium D-gluturate gets converted to glucaric acid in the body. CDG is sometime called D-saccharic acid. Calcium-D-gluturate helps to prevent the body from producing ammonia when you consume a high protein diet. If you have sulfation issues and have not addressed them you may react to CDG, it requires sulfation for the body to properly use it. If you are going to use it I would suggest supporting sulfation with things such as Pyridoxal-5-phosphate, vitamin B12, betaine, molybdenum and vitamin C. Calcium-D-gluturate helps to prevent high estrogen levels. A disruption in our gut microbes can cause high beta-glucuronide levels. High beta-glucuronide levels can cause toxins the body is trying to remove to be reabsorbed this includes carcinogenic hormones and xenobiotics. Calcium-D-gluturate prevents beta-glucuronide from disrupting the removal of toxins from the body. Calcium-D-gluturate prevents estrogen dominance. Estrogen dominance can cause breast cancer.
Calcium-D-gluturate helps to balance the immune system by activating the anti-inflammatory parts of the immune system. A deficiency in iron, magnesium, calcium or phosphorous can increase beta-glucuronidase activity. Calcium D-gluturate may reduce testosterone because it is removed with glucuronidation and CDG increases glucuronidation. Green tea inhibits glucuronidation this is why in men green tea increases testosterone. Beta glucuronidase activity has been found to be high in those with cystic fibroids and cancer in the breast. Calcium D-gluturate may help prevent that from occurring. Calcium D-gluturate has been found to help with many types of cancer including skin cancer. Resveratrol found in grape skins and grape seed extract amplifies the effects of CDG.
Cholesterol is needed by almost every cell in the body especially the brain. When LDL levels are high it indicates the body is dealing with excess inflammation and oxidative stress. Calcium-D-gluturate reduces LDL levels by reducing the oxidative stress and inflammation freeing up cholesterol to be used in other areas of the body to maintain health.
Our bodies produce a little CDG and we get some in our diets from the white parts of citrus fruits, tomatoes, bean sprouts, cruciferous vegetables like broccoli or cabbage, grapes and cherries. But if under a lot of stress, chronically ill, come in contact with a lot of toxins, eat a lot of processed or inflammatory foods, or if we have adrenal fatigue levels can become low. Most recommend 200 to 500 mg twice a day. They also recommend starting with the lowest dose first because detoxing for the first time can be very unpleasant. CDG helps prevent certain types of cancer in men and women. Reading message boards most take DIM and CDG and they stated after about a week of taking them they started to react to them, but the started pulsing them which means taking them in a spaced out manor like every other day they continued to reap the benefits without reacting to them. Because CDG detoxes adrenal hormones I suspect it may reduce the levels of adrenal hormones if taken daily. Something to take note of DIM is an aromatase inhibitor. Aromatse inhibitors can cause endometrial problems, blood clotting, heart palpitation, osteoporosis, and joint pain. So just as with any nutrient if used in excess it can start having a negative impact on the body. Though I cannot find studies to show that CDG causes magnesium deficiency many on message boards said they became deficient in magnesium when taking it so one may want to increase their magnesium intake when taking CDG. Another thing to take note of is CDG will open up detox pathways so a person may feel worse at first when taking CDG until the toxin levels come down. If the CBS pathway is upregulated and sulfation is not addressed a person may react to CDG. A person low in iron, magnesium or vitamin B12 may react when taking CDG. If a person has high mercury levels CDG can free the mercury, it would be wise to take alpha lipoic acid so they can fully detox the mercury.
People who react to plant phenols have high histamines, low copper, or high sulfite levels in the body. Increasing intake of methyl groups, and taking choline may help along with taking CDG. People who have senstivity to plant phenols will react to foods high in phenylalanine and tyramine. Consuming cheese, chocolate or green tea will cause these ones to react. Biotin can help to reduce certain hormone excess but will cause a vitamin B2 deficiency. So if you are taking biotin you will need to increase your intake of vitamin B2 deficiency will also inhibit sulfation so I would only take biotin when hormone levels are at their worse or get it from food sources.
A person with lysosomal storage issues should not take CDG. It can make the symptoms worse. It can increase mucopolysaccharoidosis. Mucopolysaccharides will build up in the liver. I suspect consuming excessive amounts of CDG could also contribute to this condition. It is why a person should work on achieving balance and learn to listen to the body.
Klotho is known to extend ones life span it is a beta glucuronidase. In science literature they list all beta glucuronidase as bad. This is not true, so we have to look past the flawed science and use common sense. If CDG inhibits beta glucuronidase it most likely is inhibiting klotho. Klotho prevents inflammation in the body and helps prevent aging.
Though there are many benefits to taking CDG I would recommend correcting the health issues causing a person to have to take certain nutrients and as they get things corrected rely on food sources of the nutrient and stop supplementing it. This would prevent them from causing other health issues from taking too much of something.
https://journals.sagepub.com/doi/abs/10.1177/1534735403002002005
https://pubmed.ncbi.nlm.nih.gov/12197785/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412524/
https://www.sciencedirect.com/science/article/abs/pii/0271531796000450
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412524/
https://pubs.rsc.org/en/content/articlelanding/2013/fo/c2fo30145h#!divAbstract
https://pubmed.ncbi.nlm.nih.gov/2346674/
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