My summarized notes.

This is not medical advice I am posting this for educational and informational reason.

I am summarizing my notes. I will update them as I go and make spelling corrections late. Just posting them now to give people an idea what to research.

 

For inflammatory bowel issues and malabsorption issues.

Many with inflammatory bowel have low Catechol-O-Methyltranserase activity. (COMT). Increasing COMT activity must be done with caution if you increase it too much you can swing things too far the other way. Decreased COMPT activity can cause high estrogen levels which effects cholesterol synthesis and can inhibit bile production. If COMT activity is low adrenal hormones will become high and so will more nuero transmitting hormones. Low COMT activity can lead to inflammatory bowel.

SAMe increases COMT activity along with 5-MTHF and folinic acid. Do not take folic acid it will make it worse. Magnesium , lithium and niacin are also needed . Methyl donors are needed for COMT but if a person has sulfation issues they should address it before taking methyl donors.

Those with low COMT need to avoid Quercetin, Rutin, Luteolin, Green Tea, Catechins, Epicatechins, Fisetin, Ferrulic Acid and hydroxytyrosol until they have address the dirty COMT gene. Also L-Dopa compete for COMT so should be avoided.

For a temporary fix reducing tryptophan, phenylalanine, and serotonin reduces high catecholamine levels from low COMT.

These flavonoids can be used by those with COMT down regulation apigenin, genistein, chrysin, myricetin, tangeretin, biacelin, scutellarein and wogonin.

MAO increasing MAO can increase COMT activity. Sirt 1 can activate MAO but is usually high in inflammatory bowel. MAO is not a good route to go because it can cause many other issues.

To address the high adrenal and neurotransmitter levels adaptogenic herbs like eleuthero, ashwanga, passion flower, Lemon balm and valerian will help normalize them.

Increasing progesterone and taking magnesium malate should help also.It will also decrease estrogen levels. Low progesterone can cause problems with sleep causing insomnia or disrupted sleep cycles. It can cause fluid retention and brain fog. It causes estrogen dominance which inhibits T4 from being converted to T3 resulting in low T3 and high T4 levels. Low progesterone can cause night sweats and hot flashes. High adrenaline levels from low COMT activity can cause low progesterone levels.

Cholesterol is needed to produce Progesterone. Stress decreases progesterone. Vitamin C, Magnesium, Zinc, B6, are needed for progesterone. Fiber helps increase it by decreasing bad hormone levels. L-arganine can help increase progesterone.

MTHFR enzyme regulates the methyl cycle issues with it can impair the bodies ability to process folate. It metabolizes folate to 5-methyltetrahydrofolate (5-MTHF). 5-MTHF coverts the ammino acid homocysteine down into methionine and glutathione. Methionine is used to make proteins utilize antioxidants, and assist the liver in processing fats. It also prevents depression and inflammation. Methionine helps convert estradiol into estriol which has weaker estrogen effects. Methionine is farther converted to SAMe which is a methyl donor and reduces inflammation. SAMe supports immune function. SAMe also helps produce certain neurotransmitters such as serotonin, dopamine, and melatonin. SAMe is involved in growth, repair and maintenance of cells.

Methylation has been found to be inhibited in those with inflammatory bowel. Methylation is sometimes referred to as transmethylation. Methylation is when a methyl group is transferred from one compound to another. One example is the recovery of methionine from homocysteine. In order to sustain sufficient reaction rates during metabolic stress this reaction requires B vitamins, B12 and foliate . Mehtyltetrahydrofolate delivers the methyl groups to form the active methyl form of B12. Methycolobalamin is required for themylation of homocysteine.

B12 or folate deficiency causes increased levels of circulating homocysteine. Elevated homocysteine is a risk factor for cardiovascular disease, metabolic syndrome and autism.

Major players in methylation are S-adenosylmethionine (SAMe), and methyltransferase (MT) which include DNA methyltransferase (DNMT), and Protein arginine methyltransferase (PRMT).

Methyltransferases remove methyl group from SAM, thereby converting it to S-adenosyl-L-homocysteine (SAH). This acts as a potent feedback inhibitor of upstream methylation reactions by blocking MT activity. The reactions are reversible.

The ratio of SAM to SAH influences whether SAH is coverted back to SAM or more likely hydrolyzed by S-adenosyl-L-homocysteine hydrolase (SAHase) into andenosine and homocysteine. Blackade of SAHase activity raises intracellular SAH levels and reduces MT activity and indirectly inhibits methylation reactions. Decreased SAHase activity causes raised creatine kinase, SAH, and raised SAM levels. Symptoms are reduced by dietary calorie restriction of methionine and supplementation of creatine and phosphatidylcholine.

Arginine methylation can increase steric hindrance and hydrophobicity but in contrast to phophorylation it does not affect protein charge.

Arginine methylation occurs in histones, trascription factors, cytoskeletal proteins, cytoplasmic signaling proteins and apoptosis proteins.

PRMT substrates are ERA receptor, others are splicing and elongating factors SAP49, UIC, CA150 and FGF-2 and Ewing Sarcoma Oncoprotein.

Problems with the vitamin D receptor can reduce tolerance to methyl donors. Impaired VDR can cause a person to be senstive to methyl donors. SAMe rescues it.

Things that can hinder or block methylation are low electrolytes, and low glutathione. High sulfite levels can cause methyl donor sensitivity. High sulfites can be cause by CBS issues, BH4 causing CBS upregulation or gut dysbiosis. Low superoxide dismutase can also cause methyl donor intolerance or sensitivity. Low methionine can cause methyl donor intolerance. If B12 is not being converted to methylcolobamin it can cause a methyl trap and methyl groups will build up making a person ill.

Homocystein in methylation. In the homocysteine cycle , homocysteine needs to be converted to SAMe and glutathione. SAMe becomes a methyl donor to support healthy methylation and glutathione goes on to act as a powerful antioxidant that slows aging.

Causes of under methylation are leaky gut, nutrient deficiencies especially B12 , low methionine, betaine, choline, and homocysteine levels. The co-factors needed are B12, folate, zinc, B2, B3 and B6.

Mast cell activation syndrome can cause high histamines. Histamines can deplete methyl groups. High basophil levels can cause under methylation. High folate levels can mask B12 deficiency.

Pathways that can lead to undermethylation are CBS, COMT, VDR, MTR, MTRR.

Supporting under methylation SAMe, 5HTP, Evening primrose oil, P5P, inositol, Vitamin A, Vitamin C, Zinc, magnesium, Trymethylglycine (TMG) also known as betaine or DMG. Also using methyl forms of vitamins may help. Folate, methionine, glutathione, natural sources of calcium like stinging nettles. Do not take copper, DMAE or choline. Some say not to take manganese but many are deficient now days and I have not seen reliable sources to show it would be bad to take when an under methylator.

Under methylation can cause many health problems. This is a list of symptoms of under methylation. CBS issues need to be addressed before addressing methylation issues or the methyl donors will have no effect.

Addictive behavior

allergic reactions

anorexia

alzheimers

anxiety

asthma

autism

autoimmunity

bulimia

cancer

chronic degenerative diseases

depression

poor detoxification

fibromyalgia

insomnia

muscle pain

low nuerotransmitters

obesity though lean people can be under methylators also.

Obsessive compulsive disorders

Phobias or fears

PCOS

mental illness

Thyroid dysfunction

Low white blood cell count

Extremely large red blood cells

andrenal fatigue

copper overload

Symptoms of over methylation

headache or migraines

rashes

irritability

increased anxiety

joint pain

muscle pain

insomnia

depression

nausea

seizures

schizophrenia

vomiting

stomach pain

sweating

rashes

hypokalemia low plasma potassium levels.

Heart palpitations

Things that support over methylation are B12, folate, niacinamide, DMAE, choline, manganese, zinc, Omega 3s, DHA and EPA. Vitamin C and E. Avoid SAMe, inositol, TMG or DMG.

Oxidative phosphorylation needs restored in inflammatory bowel. OXPHOS is the final step in cellular respiration. Increasing OXPHOS increases glycolysis. The reduced OXPHOS is a result of inhibition of the citric acid cycle. Oxidative stress can also inhibit OXPHOS. Salicylate (aspirin) causes inhibition of OXPHOS. OXPHOS is used by some cancers for growth. Salicylate inhibits the Krebbs cycle and a-ketoglutarate dehydrogenase. This is dependent on ATP and ADP just as the Krebbs cycle is.

Piperine inhibits OXPHOS so should be avoided if you have issues with it or the Krebbs cycle.

OXPHOS provides the ATP used in the brain for most synaptic events including transmitter release.

In cancer that uses the Warburg effect inducing OXPHOS kills the cancer cell but it can feed other types of cancer. Complex 1 inhibitors induce OXPHOS. This causes a back up of ROS in the cells causing cell destruction so this also shows the importance of homeostasis of OXPHOS. So we should work towards restoring what may be inhibiting it for example low NADPH levels or inhibited function of the citric acid cycle or low ATP.

Need to increase Malic Acid, tamarand, apples, pears grapes, black haw and horsetail herb. Malic acid is needed for the Krebbs cycle, reduces pain, improves fibromyalgia, it prevents kidney stones and kidney disease. It also increase the guts production of GABA.

If they cannot tolerate cold this indicates low SIRT3 levels, this will cause problems with the break down of fats, cause low ATP levels, and low glucose levels. SIRT3 increases Acetyl-CoA which fuels the Krebbs cycle. It also stimulates the Krebbs cycle to produce energy by increasing IDH2 activity which which increases conversion of isocitrate to a-ketoglucarate. This is involved in metabolism of hydroxy proline. SIRT3 is involved in ketogenesis. Low SIRT3 will cause inhibited ketogenesis. Those with inflammatory bowel issues are usually low in SIRT3 . SIRT3 increased NADPH which is usually low in inflammatory bowel and malabsorption. Excess SIRT3 will inhibit protein synthesis in the mitochondria and inhibit oxidative phosphorylation. This is one you would have to be careful in manipulating because many with malabsorption have inhibited OXPHOS. Low SIRT3 levels can lead to NAFLD and COPD it increases fibrosis. SIRT3 increases pyruvate dehydrogenase activity which is usually low in malabsorption disorders but high in some cancers. SIRT3 function is PH dependent so if we have acidosis or alkalosis those must be addressed in order for SIRT3 to function properly. Excess SIRT3 will inhibit bone growth. As with anything homeostasis should be the goal.

Things that increase SIRT3 stimulating HSP70 cold will do that. Exercise, nicotinamide riboside, PQQ, Lipoic Acid, Resveratrol, berberine, bitter melon, green tea, chinese skullcap, Leucine, hydrogen peroxide, carnitine, Kaempferol, caffeic acid, chlorogenic acid.

Ketones and a Ketogenic diet inhibit SIRT3.

NPC1 is inhibited in inflammatory bowel. Which is the cholesterol transporter. A deficiency in NPC1 causes an accumulation of cholesterol in lysosomes. This can also cause a deficiency in enzymes needed to break down fats. This is evident by high fat content in stools. Lecithin increases NPC1 but most have issues that need addressed before they can take lecithin. NPC1 deficiency causes lysosomal acid lipase deficiency this causes a disruption in vitamin A homeostasis because the vitamin A receptor becomes inhibited. SP1 transcription factor and adipocyte protein 2 interact to regulate NPC1. A deficiency in either one will decrease NPC1 activity. AP2 is high in hyperglycemia and diabetes. It is also high in obesity. I suspect that may have to do with lectin issues that can be addressed. Also AP2 has been found to be overexpressed in fibrotic types diseases like COPD and NAFLD. AP2 is increased by cAMP protein kinase. Issues with phosphorylation and dephosphorylation effect the function of AP2. AP2 is also high in diabetes and obesity leading me to believe it is an issue involved with lectin sensitivy or insulin. Studies have shown a possible connection with it and insulin resistance. I also suspect there may be issues with the LXR receptors.

ATOX1 and KPNI issues causes high unbound copper levels. ATOX1 is found in cytoplasma. It binds free metals protecting cells from ROS. It also shuttles copper from cytosol to ATPase transporters. This is vital for the subsequent insertion of copper into ceruloplasmin. It is also involved in cell cycle. When it is inhibited lipogenesis becomes inhibited resulting in cell death from increased oxidative stress. Inhibited bile flow causes a decrease in ATOX1. High C-reactive levels which is common in many tick born illnesses and mycoplasma infections cause these enzymes to become inhibited preventing copper from entering ceruloplasma causing high plasma unbound copper levels.

Low Quinone oxidorecutase levels is very common in inflammatory bowel I suspect the opposite is also true in some people. It is also known as NADH dehydrogenase. It acts on NADH and NADPH. It is involved in the first step of the electron transport chain of OXPHOS. NADH is used to create H2 in order to make ATP. NADH is then oxidized resulting in NAD+. AMP is a quinone oxidoreductase inhibitor. Certain sulfur based herbicides also inhibit Quinone oxidoreductase. Low levels of AMP makes you more susceptible to viral infection. So inhibiting AMP is not a good idea but addressing what may be causing high levels of AMP should be the goal. High levels of adenosine induces sleep and as you sleep adenosine deanimase is produced which degrades adenosine this causes us to awaken. Infection causes raised adenosine levels and they believe the body does this so it can heal. Adenosine increases insulin sensitivity. Adenosine makes the blood brain barrier more porous. Low adenosine causes an increase in dopamine and glutamate. So you can see inhibiting AMP could cause some problems. It is best to increase adenosine deanimase. Adenosine deanimase deficiency has been linked to decreased IL-2 which modeulates the immunes system to help it recognize the difference between something foreign and self. Adenosine deanimase defficiency has also been linked to thymus cell death, lung inflammation and defective T cell receptor signaling.

Zinc deficiency can cause a deficiency in Adenosine deanimase. Estrogen also induces adenosine deanimase so high can most likely cause a depletion of adenosine causing the inability to sleep. Insulin Like Growth Factor 1 also increases Adenosine deanimase. Protein, casein in milk products , calcium, blue berries, resveratrol, vitmain C, cinnamon, prolactin, leucin, magnesium, selenium, astragulus, eleuthero, ursolic acid and carnitine increase adenosine deanimase.

Things that inhibit adenosine deanimase are IL-13 which is high in those with allergies. Berberine and curcumine also inhibit adenosine deaminase. Nitric Oxide also inhibits it. So if you have trouble sleeping using these may help.

ACMSD, SIRT1 and AMPK are high in inflammatory bowel and need decreased.

ACMSD is involved in the metabolism of tryptophan into NAD+. ACMSD is part of the Kynurenine pathway. Amino-B-Carboxymuconate-semiadehyde-decarboxylase limits quinolilinic acid formation by competitive production of picolinic acid. A deficiency in ACMSD can lead to depression and even suicidal behavior.

ACMSD is stimulated by iron (Fe2). Toxins and infections can cause oxidative stress which causes the iron in the body to be converted to Fe3 making it unavailable to the body for use. This can cause iron to build up in the body and become toxic. Lactoferrin and curcumin can restore iron homeostasis. Curcumine if taken too long can cause anemia because it chelates iron so should not be used long term. Lipocalin 2 also restores iron homeostasis. Knotgrass stimulates lipocalin 2.

ACMSD is also stimulated by carbondioxide. (CO2+). There are methods of increasing CO2 levels safely like holding ones breath or breathing into a bag. This should be done with caution because CO2 can cause the body to become more acidic.

A diet high in phytic acid can increase phytol in the body. This can activate PPARa which inhibits ACMSD which causes a rise in blood plasma levels of NAD. But it also increases quinolinic acid which can damage the NMDA receptor and other areas of the brain.

SIRT1 activates and silences many genes that promote health and longevity.

SIRT1 used to be called the anti-aging because it slows aging. In some cancers SIRT1 is elevated. If SIRT1 is activated for too long it will cause oxidative stress. So you can see the importance of SIRT1 homeostasis. Now those who have high SIRT1 levels should not worry about what increases it but should focus on decreasing it because just about everything increases SIRT1. Those with high SIRT1 levels tend to be under weight while those with low levels tend to be overweight. SIRT1 increases as NAD+ levels increase because it requires NAD+ to function. SIRT1 removes acetyl groups off proteins. SIRT1 turns inflammatory genes off. SIRT1 turns the genes off for fat storage and synthesis and the genes for managing blood sugar levels. Acetyl groups are added to groups in response to changes made by inflammation and oxidative stress. SIRT1 can reverse Leptin resistance which is common in obesity. SIRT1 can cause you to be sensitive to T3 which can cause high T4 levels and low T3 levels. This can cause a person to be sensitive to cold. SIRT1 can increase estrogen levels by increasing estrogen receptor signaling. SIRT1 and resveratrol makes you more sensitive to vitamin D. SIRT1 inhibits IGF-1 which is used to build muscle and is crucial for healing. But high levels of IGF-1 can promote cancer. SIRT1 inhibits mTOR which is involved in inflammation and aging. SIRT1 protects us from nitric oxide. Nitric oxide stimulates DNA repair via deacetylation of FOXO1. Without SIRT1 NO would cause cells to self destruct. SIRT1 increases adipopectin which stimulates TH17. High adipopectin has been linked to autoimmunity. High TH17 levels causes inflammatory skin diseases such as Lupus. High TH17 levels causes arthritis which is why high adipopectin levels have been linked to arthritis. Adipopectin stimulates weight loss. SIRT1 decreases NRF2 which is the master regulator of the antioxidant system. Acetylation allows NRF2 to bind to DNA better and as mentioned earlier SIRT1 removes acetyl groups which would inhibit NRF2 binding. SIRT1 decreases pancreatic B-Cell proliferation (growth or production) which can lead to diabetes. GLP-1 which is usually low in inflammatory bowel blocks the effects of SIRT1. Low nicotinamide inceases SIRT1 high doses inhibit it. High SIRT1 levels can impair liver repair.

As stated earlier do not worry about the things that increase SIRT1 because they are numerous but worry about the things that disrupt SIRT1 homeostasis like low GLP-1 levels. This is a list of things that increase SIRT1, NAD+, DHA, Cold, Forskolin, adrenaline by increasing cAMP which increases SIRT1, exersize increases SIRT1, Sunlight increases SIRT1, Fructose , olive oil, zinc, green tea, PQQ, curcumin, pterostilbene, cacitrol, lipoic acid, fisetin, berberine, Pau D Arco which contains Beta Lapachone, Gotu Kola, grape seed extract, Salicylic acid, kelp, quercetin, bitter melon, pyruvate, lycopene, and butein all stimualte SIRT1. Other things that increase SIRT1 are hydrogen peroxide usuall formed from toxins in the body or infections, fasting causes high ketone levels which increases SIRT1, Hydrogen sulfide increases SIRT1 which is produced in gut bacteria when we have gut dysbiosis and by the body. Saunas, malic acid, oxaloacetate, apagenin, Lithium, succinic acid, tryptophan, and aspartic acid which are fuels for NAD+. Those things are raised when we have metabolic issues that need addressed.

Things that increase NAD+ also increase SIRT1

Some things that inhibit SIRT1 are PPAR gamma, melatonin, IGF-1, genistein, and an antibiotic trichostatin. PPAR gamma regualates fatty acid metabolism and glucose homeostasis and has been found to be low in those with inflammatory bowel. Low levels of PPAR causes muscle fatigue. Stimulating the retinoic acid receptors increases PPAR, Honokiol found in magnolia stimulates PPAR gamma . High vitamin D levels prevents PPAR from binding to DNA which would inhibit it’s effects. We do not want to increase PPAR gamma to much because it can lead to acne, fluid and sodium retention. AMPK which is usually high in inflammatory bowel inhibits PPAR gamma. Low PPAR gamma levels makes it difficult to gain weight. Those with low PPAR gamma need more carbohydrates. Cold and nitric oxide can increase PPAR gamma.

Insulin-Like growth factor 1 (IGF-1) also known as Somatomedins and sulfation factor. It is involved in the incorporation of sulfur into cartilage for proper cartilage health. IGF-1 has been found to be low in inflammatory bowel and those with high TH17 levels like lupus. IGF-1 increases antioxidants and decreases inflammation. IGF-1 protects us from autoimmunity. IGF-1 improves memory, acts as an antidepressant and reduces anxiety. IFG-1 restores bone density. IGF-1 improves gut health and nutrient absorption. IGF-1 helps maintain electrolyte balance. High levels of IGF-1 causes acne. Excess IGF-1 causes enlargement of internal organs and excessive bone growth. High levels can lead to diabetes, headaches and blurred vision. It can also cause low sex drive and swelling in limbs.

Things that increase IGF-1 are high calorie intake, protein consumption, casein in milk products, vitamin C, blue berries, growth hormone, cortisol, dhea, parathyroid hormone, prolactin, cinnamon, magnesium, eleuthero, ursolic acid, carnitine, dried plums.

Things that reduce IGF-1 are fasting, protein restriction, royal jelly, glucosamine, berberine, luteolin, curcumin, resveratrol, apagenin, lycopene, green tea, boron, inflammation, and histamines.

AMPK- 5, andenosine monophosphate-activated protein kinase. It plays a role in cellular glucose homeostasis, it is the bodies energy sensor. It activates glucose and fat uptake oxidation in cells when energy is low. It is stimulates fatty acid oxidation and ketogenisis. It inhibits cholesterol synthesis and lipogenesis and trygliceride synthesis , and inhibits adipocyte lipogenesis and inhibits activation of lipolysis. This results in low cholesterol levels with HDL being lower then LDL. This inhibits the breakdown of food into energy. It also inibits protein synthesis leading to many issues especially pheylketonuria. Lypolysis is how our bodies store energy and when inhibited we will have severe weight loss. This takes place in the CBS pathway. High levels of AMPK is common in inflammatory bowel and malabsorption. AMPK is activated by AMP and inhibited by ATP. Hypoglycemia and hypoxia stimulate AMPK. So if we have low glucose levels AMPK will be high causing the CBS pathway to become upregulated which causes high sulfide levels resulting in many health problems and we will start developing a sensitivity to meat and sulfur containing drugs and foods. AMPK levels are low in those with type 2 diabetes and those who are obese. Upregulation of the CBS pathway also causes high hydrogen sulfide levels which can cause low blood pressure and the production of excess free radicals. It also increases nitrosative stress. Excessive weight gain could indicate low AMPK levels excessive weight loss could indicate high AMPK levels. High AMPK levels can result in a lower body temperature. High AMPK levels inhibit PPAR which I discussed earlier. High AMPK levels can make us more prone to viral infections.

Panex Ginseng , green tea, black tea , snow lotus , salicylate and Curcumine should be avoided by those with upregulated CBS or high AMPK levels because these increase AMPK levels. This may help those with type 2 diabetes or obesity because they would increase fat oxidation. S-adenosyl-L-methionine (SAM) inhibits AMPL decreasing the upregulation of the CBS pathway. Nitrosative stress and oxidative stress activate AMPK. Low AMPK levels can cause glycogen storage disease.

Things that increase AMPK are exercise, fasting or calorie restriction, cold exposure increases AMPK. Resverotrol, quercetin, genistein, berberine, curcumin, anthycyanines found in purple fruits, bitter melon, fish oil, carnitine, astragalus, olive oil, creatine, biacalin found in sculletaria, fleabane and plantain herb, fucoiden all stimulate AMPK.

Things that inhibit AMPK are consumption of proteins especially branch chained proteins, high glucose consumption, saturated fat and insulin. For those who have high levels of AMPK it is important to address the cause because the foods that upregulate it are numerous and we cannot avoid them, also they are needed to remain healthy so avoiding them would only add to the problem and prolong our illness. Glucose consumption and increasing ATP will reduce AMPK.

The Krebbs cycle is needed to produce ATP so issues with the Krebbs cycle need addressed. If COMT is low it will lead to issues with the Krebbs cycle and so can low glucose levels. High hydrogen sulfide levels from gut dysbiosis can cause issues with the Krebbs cycle and the CBS pathway. CoQ10 can increase ATP levels. Medium chain fatty acids can increase ATP levels. Glutathion, Vitamin C and vitamin E indirectly increase ATP levels. Cordyceps mushrooms increase ATP levels. Raising ATP levels also improves cognitive function. Pyruvate, cratine and L-carnitine also increase ATP levels. Ribose helps increase ATP production. The B vitamins are needed for ATP production. Magnesium is also needed for ATP production. Strength training improves the bodies ability to produce ATP. Adrenal fatigue can cause low ATP levels. Adaptogenic herbs help restore normal adrenal levels.

Hypoxia, chemicals especially glyphosate and heavy metals can decrease ATP. Dehydration inhibits ATP production so we must stay hydrated with fluoride free water.

Thiol persulfuration is high causing an increase in H2S which can cause inflammation and low blood pressure. This can be caused by frataxin overexpression. This can result in iron accumulation in the cells and increased oxidative stress. P5P, and ubiquinol help.

If you are deficient in flaxatin iron can build up in the cells reducing excess iron in the body and vitamin C help. Curcumine, and lactoferrin can help by reducing iron levels. Curcumin should be used with causion. Taking it for too long can cause anemia. Lipocalin 2 helps restore iron homeostais. Knotgrass stimulates lipocalin 2. It is needed to generate heme groups so we do not want to inhibit frataxin production. We need to focus on reducing oxidative stress and inflammation. HDAC inhibitors increase frataxin. Iron regulatory protein 1 and 2 regulate flaxatin levels. Increased Irp1 and Irp2 expression increases flaxatin. Hepciden regulates Irp1 and Irp2. During infection and inflammation hepcidin increases inhibiting the ability of iron to be absorbed. This causes hypoferremia a type of anemia. It does this to decrease inflammation and to inhibit the pathogens ability to use iron. A hepcidin deficiency can cause iron overload. Though there are no studies on it, it is clear that hepcidin levels can effect thiol persulfuration. So low hepcidin levels would most likely increase persulfuration and high levels would decrease persulfuration. Low levels of iron increase hepcidin and high levels increase hepcicin. High hepciden levels are linked to inflammatory bowel diseases which leads me to believe there is a link to infection that is being overlooked. High hepcidin levels can lead to atheriosclerosis. High hepcidin levels can cause sleep apnea. Hepcidin is high in psoriasis. Low hepcidin levels can increase iron absorption into the body causing iron toxicity.

Things that decrease hepcidin. Vitamin D , STAT3 inhibitors, salicytic acid, Reducing IL-6, alcohol, smoking, testosterone and estrogen.

So if we need to increase heocidin increasing STAT3, IL-6 and other things that cause inflammation should increase hepcidin.

increasing intrinsic factor to improves nutrient absorption especially B12. Gentian root increases intinsic factor. A sign if malabsorption is swelling of the tongue. It is one of the first nutrients to become deficient in malabsorption. Avoid acid blocking drugs. Stomach acid is needed to absorb B12. Increasing stomach acid helps to absorb B12. Apple cider and bitter herbs help increase intrinsic factor. Thyme increases stomach acid. Dandelion and sea salt also promote stomach acid production.

Damage to the gut which is common now because of the BT Toxin and glyphosate in our food causes a loss in intrinci factor production because the pareital cells that generate intrisic factor becomes damaged. Once B12 levels drop it can start a cycle that is hard to break. Sublingual B12 can help , putting it under the tongue can help the body to absorb it. In some the nutrient deficiencies caused may cause issues with converting B12, P5P may be needed also to help with the conversion of B12 to a form the body can use. The B12 deficiency causes inflammation in the gut which farther inhibits nutrient absorption.

We must work on protecting and restoring the mucous membrane for parietal cells to regenerate. Bismuth can help protect the gut permitting it to repair.

Histamine, acetylcholine and gastrin regulate intrinsic factor production. Many are deficient in choline which would inhibit the production of intrinsic factor. Also H2 inhibitors will inhibit histamines which will inhibit production of intrinsic factor.

BHMT (Betaine homocysteine S-methyltransferase is usually low in those with inflammatory bowel but if they have PEMT issues it can cause problems. Betaine taken with pepsin help break down food better and increase gastric acid which should reduce GERD caused by inhibited bile. Hypothyroidism, high estrogen levels, low COMT disrupts hormone levels which can cause low stomach acid levels. Betaine is also know as trymethylglycine or TMG. Betaine increase BHMT levels. Betaine also increases methionine. Vitamin B6 , magnesium and zinc deficiencies can cause low stomach acid levels. Also if you are low in choline needed for neurotransmitters it could slow stomach acid production down. to increase BHMT lysine, choline, creatine, ursodeoxycholic acid, thiamine, mirocholic acid, methylfolate, and methionine are needed. The supplement trymethylglycine also known as TMG is betaine that was extracted from plant sources. Pineapple , beets and golden rod are high in betaine. Betaine, along with glutathione. TMG lowers the burden on the CBS pathway and also helps reduce ammonia levels. It helps the body to recycle phenylalanine preventing it from being converted to ammonia.

PCYT2 inhibition causes weight gain and overexpression can cause weight loss. Low PCYT2 Expression can cause diabetes type 2 and obesity. Phosphate Cytidylyltransferase 2 deficiency causes increased lipid absorption. PCYT2 is found to be common in polycystic fibrosis. PCYT2 deficiency causes a rise in PUFA which causes inflammation. PCYT2 is inhibited by Liver X Receptor activation, vitamin D3 activates the LXR. Oxeysterols also inhibit PCYT2. Oxysterols are cholesterol derivatives.

Leptin causes problems in inflammatory bowel and improving leptin sensitivity is important. Being sensitive to leptins can cause weight loss. Leptin resistance is different it causes obesity. It is important to decrease leptins until the issue is resolved. When you eat leptin it signals that you are full, it lets the brain know to stop eating. High leptin levels will cause the brains letpin receptor to become desensitized to leptin. Processed sugar can desensitize the leptin receptors. When that happens we will keep binge eating. High testosterone and high estrogen levels can cause leptin resistance. High insulin levels can cause leptin resistance. Leptin resistance can cause carbohydrate cravings. Leptin resistance can cause high C-reactive proteins in the body. That causes inflammation and can cause high unbound copper levels in the blood.

High leptin levels can cause osteoperosis and joint damage. Leptin increase metalloproteinase enzymes which cause cell death of the chondrocytes the cells that produce cartilage. High Leptin levels can cause autoimmunity. Leptin resistance also causes elevated free fatty acids.

When functioning properly as we eat and fat levels rise leptin goes up signaling that we have enough calories. When fat levels drop leptin levels go down signaling we need calories. When a person becomes leptin resistant they will feel sluggish because the body tells them to rest to preserve calories because the brain thinks they are starving. Losing weight causes a drop in leptin which will increase hunger. Inflammation, infection, high free fatty acid levels and high leptin levels can cause leptin resistance. This can lead to type 2 diabetes, hypertension, atherosclerosis and insulin resistance. Low melatonin levels can cause this. Studies have shown those who have leptin resistance improve when they get more sunlight. Being deficient in certain gut bacteria can also cause leptin resistance. The gut bacteria that keep us from developing leaky gut and the ones that produce short chain fatty acids prevent leptin resistance. Also health conditions like acidosis and alkalosis can cause changes in FFA levels. Acidosis can reduce FFA levels in the blood. Alkalosis can increase FFA levels. Those with acidosis should not drink alcohol because it increase acidosis. Alcohol consumption causes an increase in acetate which causes the PH of the blood to become more acidic over consumption can cause lacticacidosis.

Things that help with leptin resistance are avoiding processed foods, avoiding consumption of processed sugars including fructose and even processed honey can contribute to it. High T4 levels can cause leptin resistance which could indicate COMT deficiency and high estrogen levels. Honey that is raw does not seem to have these effects. Increasing protein consumption improves leptin sensitivity.

Leptin sensitivity is different, it is caused by leaky gut and causes fatigue, mental illness, skin rashes, allergies, nausea, muscle weakness, numbness and you become more prone to illness. You will also develop gas, bloating, headache, indigestion , diarrhea/constipation and may develop autoimmune or generative disease. Lectins should not be mistaken for Leptin which is different.

This will make you sensitive to nuts, grains, eggs, milk products, legumes, seeds, potatoes, melons, squash and other high lectin foods. Those with lectin sensitivity will usually be underweight but not always. High ketone levels can cause leptin resistance.

Herbs that reduce inflammation and also Omega 3s which help reduce inflammation increases leptin sensitivity. Correcting things that can cause disrupted sleep patterns increases leptin sensitivity. Also addressing infections will improve leptin sensitivity.

Leptin is produced in fats cells in the body. When a person loses weight the fat cells release leptin which makes the body think it is starving. High leptin levels makes us more sensitive to pain. It can also makes us more susceptible to allergies. High leptin levels can cause inflammation.

Phospholipase A needs reduced it is high in inflammatory disease especially inflammatory bowel. High Phospholipase can be caused by infection, toxins like mercury and fluorquinolone injury. Farm chemicals found in our food especially glyphosate can also cause high PLA levels. This leads to leaky gut, gut inflammation, it can eventually lead to many metabolic issues, it can cause arthritis, heart disease, it can damage the liver and pancrease. It can also damage cells and cause cell death.

Those with high PLA levels should avoid Omega 6 fatty acid. PLA increases the fatty acids in the body that causes inflammation and it also increases inflammatory cytokines. It can also increase substance P levels which increase inflammation. It also causes lipids to be oxidized which can prevent the body from being able to properly use fats which are very important for our health. Our brains need fat so it can lead to mental illness. It also causes oxLDL levels to become high.

Some things that inhibit PLA are bitter melon, Omega 3 fatty acids, butyrate found in butter, magnesium, P5P, curcumin, indole, Ginkgo Biloba, Gotu Kola, Ashwangha, Tamarind and natural COX inhibitors reduce PLA.

HSP70 Stimulation helps resolve many issues with inflammatory bowel.

Most with imflammatory bowel need to increase CO2 levels.

Natural calcium channel blockers like hawthorn and magnesium help with inflammatory bowel.

Increasing Ghrelin and motilin improves digestion and gut motilility.

Almost all with inflammatory bowel have high benzoic acid levels and need to reduce it.

Most with inflammatory bowel have high estrogen levels. Inhibiting Sulfatse helps reduce estrogen.

SULTE1 is inhibited and needs increased.

NRF2 activation will increase estrogen sulfotransferase which will decrease estrogen. Selenium is needed.

Chaste berry reduces estrogen and increases progesterone.

Passion Flower is high in chrysin which reduces estrongen but long term use can damage the liver. It also reduces pain and anxiety.

Ellagic Acid reduces estrogen

Maca root restores hormone homeostasis and so does suma root. Kudzu does but should not be used by those with high acetaldehyde levels.

MOGAT3 is disregulated in inflammatory bowel. High levels cause weight gain and low levels cause weight loss.

Heme is usually low in inflammatory bowel but Fe3 levels are usually high. Lactoferrin and curcumin help with this. They restore iron homeostasis but if you take curcumin for to long it can chelate iron from the body causing anemia. Stimulating lipocalin 2 with knotgrass can also restore iron homeostais in the digestive system.

UDP-Glucose is usually low in inflammatory bowel and needs increased.

Many have problems with vitamin D mushrooms have a type of vitamin D the body can easily convert and use and usually will help those who have vitamin D issues.

Oxesterol is usually high in inflammatory bowel.

Cholecystokinin is usually high in inflammatory bowel. Things that reduce CCK are trypsin, capsaicin, amylase, stimulation from cold, calcium channel blockers like magnesium and hawthorn, or calcium chelators.

PKC,Pka, CamK2, cAMP and Calmodulin are low in inflammatory bowel.

T4 is high in inflammatory bowel. Reducing IL1, IL-b, IL-6, TNF-a, and interferon B will reduce T4. Increasing iodotyrosine, deiodinases help recycle thyroid hormones restoring homeostasis. Iodine, selenium and tyrosine are needed. This can cause high B-OHB levels, high ketone levels and can eventually lead to ketoacidosis. This also causes increase in glucokinase. This can cause high Glucose-6-Phosphate levels which will disrupt lipid homeostasis. N-acetylcysteine decreases G6P activity.

High Aspirin and high heperin can cause high T4 and may need reduced.

High T4 levels is usually and indication of high porphyrin levels which can be caused by metabolic issues or high acetaldehyde levels.

Reduce arginine vasopressin if plasma glucose and sodium levels are high increase it if they are low.

Quinolinic acid is high in inflammatory bowel this is caused by tryptophan issues. Tryptophan is needed so we cannot avoid it 5-htp supplement will usually prevent this.

Glycyl-Alanyl-Histidine is usually low and needs increaseased.

Many with inflammatory bowel have high oxalates. Sodium Benzoate used in pickles will increase hippuric acid which reduces oxalates. Also phenolic compound will decrease oxalates these are high in fresh fruit juices.

SLC2bA1 is low in inflammatory bowel. It needs B1, B2, B3, B6, calcium, colbalt,and alpha lipoic acid. Inhibited SLC2bA1 caused poor B6 activity. B1 needs magnesium and manganese. B2 needs ATP and magnesium. B6 needs zinc, lysine, magnesium, thiamine, and niacin.

Most with inflammatory bowel have low methionine synthase levels. This will cause D3 to not be converted and the body will change it and store it instead of using it. This can lead to parathyroid issues.

Most with inflammatory bowel are low in vitamin K2 levels.

Inflammatory bowel causes Alanine glyoxalate and glyoxalate reductase deficiency. These need increased.

P5P stabilizes AGT

Need to get your gut bacteria straightened out it is causing high H2S levels which binds to cytochrome oxidase which slows the metabolism down.

You need to avoid all oils as much as possible and only get medium chain fatty acids like coconut oil and palm oil. Cod liver oil would help also but make sure it contains lemon juice, it usually oxidizes quickly if it doesn’t.

Fulvic acid and humaric acid are the same but the body can more readily use fulvic acid. Continue to use it.

I believe if you supplemented Oxaloacetate it would help your citric acid cycle and bile flow.

Acryl-CoA:cholesterol acetyltranseferase is reduce in inflammatory bowel which effect bile production. It also inhibits function of the Krebbs cycle. Malic acid and B12 are needed to restore ACAT.

Many with inflammatory bowel have SOUX upregulation which upregulates the CBS pathway which leads to high sulfide levels which can inhibit sulfation. Reducing high sulfur goods and getting sulfate a form of sulfur the body can readily use will help. Water from volcanic sources and hot springs are high in sulfates. This can cause low NADH , low ATP levels and low vitamine E levels. It can also deplete malic acid. P5P, molybdenum, manganese, selenium, and magnesium usually help with this. Also soaking in epsom salt and getting 20 minutes of sunlight will help more if you are dark complected.

Inflammatory bowel causes Serine Dehydratase deficiency so it needs increased.

Diglycinate incereases stomach acid levels, it is a type of glycine. Those who have glyoxalate issues may not be able to take this one.

Hexokinase is low in inflammatory bowel. Increasing it helps .

MT-Kinase is low in inflammatory bowel.

GLP-1 is high and GLP-2 is low in inflammatory bowel.

Increasing GIP helps with inflammatory bowel.

DPP4 regulates dipeptidyl peptidase. Upregulating helps with inflammatory bowel. IL-1a increases DDP4 activity. It is also known as fibroblast growth factor.

Protectin 1 is low in inflammatory bowel.

Gycogen synthase is high in inflammatory bowel. Bioavailable copper is needed to reduce it, lithium, zinc, melatonin, curcumin, quercetin, cinnamon, and angelica reduce it.

Stimulating PGC1 helps restore glucose homeostasis. It also stimulates HNF4a. PQQ, curcumin, green tea, vegetables and fresh fruit juice stimulates PGC1.

HNF4 gene regulates TCF7L2. Increasing TCF7L2 improves blood glucose levels, and strengthens intestinal barriers. Most fats inhibit TCF7L2 medium chain fatty acids are required to prevent inhibiting TCF7L2.

Arginine methyltransferases (PRMT) enhances HNF4a. P38 is needed to phophorylate HNF4a.

High Tyrosine Kinase levels inhibit HNF4a.

Inceased cAMP/PKA activity inhibits HNF4a activity.

AMPK inhibits HNF4a.

PGC1a activates HNF4a.

SRC1-3 are steroid receptors. Enhance activity increase HNF4a activity.

Hes6 is a transcriptional factor in HNF4a displaces cofactors of PG1a and CBP from HNF4a. Ketones causes it to become down regulated.

Deficinecy in HNF4a dcreases bilea dn raises T4 levels. Stimulating PXR helps resolve this.

Increasing phosphorylatiohn of FOXO1 by insulin P13K pathway reverses repression of HNF4a via SREBP+FOXO1.

Inflammation and metabolic issues decreases HNF4a.

Increasing SHBG reduces estrogen.

Increasing prohormone convertase 2 enzyme helps restore glucose homeostasis.

Reducing glycetin helps restore gut motility and reduce excess insulin.

High AMPK levels inhibits protein producion and is high in inflammatory bowel.

Oxaloacetate is low in inflammatory bowel witch cause high B-hydroxylbutyrate, it also causes Acetyl-Coa to be shunted towards ketone body production which inhibits histone deacetylase. This also leads to inhibited gluconiogenesis, inhibited urea cycle, inhibited glyoxalate cycle, inhibited bile acid production, inhibited amino acid synthesis and inhibited citric acid cycle.

Increasing NADHP and decreasing NADH increases citrate cynthase and can help restore proper citric acid cycle function.

AGT function is usually inhibited in inflammatory bowel causing high oxalates and inhibited mitochondrial function.

Increasing P5C reductase and Proline oxidase helps with inflammatory bile. They require ornithine.

After the citric acid cycle is functioning increasing Hydroxy Proline Oxidase to help with inflammatory bowel.

KIM1 levels are high in inflammatory bowel which can damage the liver.

All these need increased to help with the many health issues caused by inflammatory bowel. L-Propyl-L-Proline, N-acetyl putrescine proline, taurine, uric acid, L-Pipecolic Acid, L-methionine, N-Acetyl-L-Methionine, 3-Methoxytyrosine, 7-methylguanine, unsaturated fatty acids like decatrienic acid and sebacic acid. Phenylacetic acid and phenylacetyl-glycine need increased.

Nicotinate and nocotinamide are low and need increased.

Need to increase B vitamins using bioavailable forms works best and should be taken with food to prevent a sugar crash and flushing.

Cindoxyl,3-hydroxyquinoline, 3-methyl oxyindole, indoleacryilic acid, indolxylsulfuric acid and xanthurenic acid need increased.

Taurocholic acid needs increased.

Kynurenine needs increased to prevent high quinolone levels.

Taurine needs increased to prevent high ammonia levels, reduce oxidative stress, increase bile flow. Glycine helps for those who do not have glycine issues.

Chondroiton sulfate helps reduce oxalates. I had sulfation issues but it did not seem to raise my sulfide levels.

Need to increase Taurocholic acid and taurodeoxycholic acid.

Need to increase carnitine to improve B-oxidation of fatty acids. This should increase Propionyl-L-carnitine which reduces NOX4 mediated oxidative stress and restore endothelial function.

Need to increase protein metabolism, betaine, bromelain, P5P, magnesium, molybdenum, manganese, cobalt , selenium usually help with that.

Vitamin C needs increased to help with metabolic processes but should be used in moderation in those with inflammatory bowel because to much vitamin C in those with inflammatory bowel can cause excess to convert to oxalates. That is the result of ascorbate 2-sulfate deficiency.

Inhibiting HAO1 prevents excess D-ammino acid activity. It prevents glycolate from being converted to glyoxylate.

Increasing Lactate dehydrogenase reduces oxalate in the renal system.

AGXT (serine-pyruvate aminotransferase) is needed to detox glyoxalate. Marshmallow root increases AGXT.

Increasing Etholamine pretects cells from ROS, restores cellular membrane function and signaling and improves bile flow.

Increasing D-bifunctional protein prevents muscle weakness, seizures, fatty acid accumulation, decreases palmitoyl CoA oxidase, peroxisome thiolase and branch chain acyl-CoA.

Increased phytanic acid oxidase prevents fatty accumulation in the liver. Excess branced chain fatty acids inhibit phytanic acid and cause it to accumulate in the liver which leads to hyperkerotosis. Increasing urea can help with this. This can also lead to adrenoleukodystrophy which causes the enzymes for fatty acid to not to function properly causing very long chain fatty acid build up. This is caused by ABCD1 issues and can result in cerotic build up.

Lorenzo’s oil can correct this conditon. It is 4 parts glyceral trioleate and 1 part glycerol. These are forms of oleic and euric acid made from olive oil and oil from olive seed. If not corrected ti can lead to the accumulation of VLCFA which causes A-Methylacyl-CoA Racemase deficiency. This can cause an accumulation of bile acids. Reducing phytanic and pristanis helps.

Dequaliniun Chloride helps resolve AGT deficiency and AGT misdirection.

By correcting issues causing excess ketone it will reduce acetoacetate, beta-hydroxybutyrate and acetone.

Increasing Pyridine nucleotides improves redox status.

Increasing NADPH oxidase increases SOD. This also blocks inflammatory causing enzymes, reduces cyclogenases and prevents thrombosis.

Increasign Lipoxin A4 decreases inflammation

Increase NADK to improve NAD binding and improve phosphorylation. Magnesium, zinc and CO2 are required.

Reduce PKC to reduce inflammation and gene overexpression.

NADPH oxidase over activation depletes NADPH. Inhibiting it can raise NADPH levels. Tripterygium wolfordii and magnolia inhibit NADPH oxidase. Nitric Oxide also inhibits NADPH oxidase. Gingko biloba inhibits NADPH oxidase but there are studies showing using it for three months or more may damage the liver.

Iron overload decreases NADPH. Lactoferrin, curcumin, and lipocalin 2 help restore iron homeostasis. Taking curcumin for to long can make you anemic because it chelates iron .

Reducing hemolysin prevents thrombosis and fibrosis and reduces H2S. When H2S levels are high it can lead to inflammation and low blood pressure.

Gut bacterias effects on inflammatory bowel.

Those who have inflammatory bowel are defecient in Short chain fatty acids. Akkerinmania municiphila, roseburia intestinalis hominis, inulinivorans faecis ceciola regulates metabolism, produce butyrate and SCFA. They also help restore our beneficial gut bacteria.

Lactobacillus Casei and L Longhum have to be taken together one cannot exist without the other. They keep the antioxidant system at homeostasis and also regulate autophagy.

Lactobacillus reuteri produces folate.

Bacillus infintas reduces inflammatory bowel

Bacillus subtilis produces antibiotics and protects the gut from infection.

Bacillus Clausii prenents diarrhea and reduces inflammatory bowel.

Most with inflammatory bowel have high copper these are some things that may help. This also improves bile flow.

4 ounces of fresh orange juice

¼ teaspoon of sea salt

8 ounces of coconut water

60 mg whole food vitamin C

3 teaspoons of cream of tartar.

For the adrenal fatigue caused by high copper adaptogens like maca root and suma root help. Magnesium, boron, sodium bicarbonate and B vitamins from mushrooms or bee pollen, kelp for iodine and eggs for biotin. Taurine for the liver, molybdenum chelates excess copper. Do not take high doses of vitamin D it inhibits cerruloplasmin raising unbound copper levels. Fluoroquinolones, fluoride, glyphosate can cause high unbound copper levels and will need to be detoxed. Silica helps reduce unbound copper levels.

SULTE1 upregulation improves bile flow and reduces estrogen and reduces high levels of biounavailable copper. Increasing Adenylcyclase also helps.

Increase vitamin K2 to prevent oxalates.

BH4 is needed for proper eNOS function. BH4 inhibits excess gluconeogenisis. AMPK suppresses effects of BH4. High AMPK levels lead to high ketone levels.

GTP (quanosine trisphosphate) is the rate limiting enzyme for BH4 enzyme. Increasing GTP reduces excess succinate in the TCA cycle. Restoring NO bioavailablility and increasing DHFR with folinic acid restores BH4 levels. 5-HTP will also help restore BH4 levels.

A deficiency in BH4 can cause a B12 deficiency.

AMPK Kinase inhibits cholesterol production which negatively impacts bile production, Excess Nitric Oxide activates AMPK Kinase

Fumarate increases oxidative phosphorylation in the Krebbs cycle to reduce ketones, and lactic acid. This will increase adenosine monophosphate.

Cholestasis needs resolved . Increasing bile salts and medium chain fatty acids help and improves bile flow.

Cyclohexancaroxaloic acid, propanoic acid, buranoic acid, decanoic acid and hexanoic acid. Cicetic and Petane. Reduce inflammatory bowel.

NAC and threonine can help.

Allicin reduces acetic acid producing bacteria.

Pantothenic acid cannot function if biotin is low.

If Lipoate is deficient the antioxidant system cannot function.

Biotin requires butyrate and acetate to be absorbed. Low biotin levels causes high B12 levels because your body will be unable to convert it. Brewers yeast and eggs are high in biotin.

Hydroxylase syntase deficiency cause a loss in the ability to metabolize proteins, fats, and carbohydrates. It is dependent on biotin.

When you have inflammatory bowel you have to take nutrients in this order. First biotin, adenosylcobalamin then choline. Then sunflower seeds, mushrooms, small amounts of whole grains, bioavailable forms of B vitamins, and methyl groups.

N-methyl transferase needs increased in those with inflammatory bowel.

N-methylglycine needs increased to prevent psychosis and depression.

Increasing Alkaline Phosphatase increases the guts good bacteria. Cissus Quadrangularis increases it and so does curcumin, cod liver oil, zinc also increase ALP.

ALP stimulates bone growth.

FXR needs stimulated it is inhibited in inflammatory bowel. This corrects cholesterol production, bile production and reduces inflammation.

Motilin needs increased to improve bowel motility and prevent GERD.

Metlatonin needs increased to correct many issues.

Things that may decrease estrogen.

Inhibiting ERa receptor decreases estrogen. Genistien, diadzein, ursolic acid, green tea, kaempferol and narigenin, and phloretin found in apple leaves inhibit ERa. These also reduce Cholecystokinin.

Other things that reduce CCK are ursolic acid found in apple skins and leaves which also contain phloretin which inhibits CCK. Grapes, tomatoes, squash, thyme,rosemary , lettuce, St Johnswort, aloe vera, moringa, elderberries and endive reduce CCK.

Stimulating complement protein C2 reduces estrogen. Cod liver oil, phytoestrogens found in plants, DIM, B12, P5P, Magnesium, and increasing SAMe will increase C2 . It is found a part of the immune system so you do not want to overstimulate it.

To repair cells fructooligosaccarides and glycerophopholipids are needed. Also fructans, pectin, Beta glucans and resistant starches are needed. Many of these can be found in raw milk, clostridium, and whey protein, along with mushrooms and seaweed.

SHBG-sex hormone binding globulin is a protein when found in high levels will cause obesity , type 2 diabetes. Low levels cause hyperthyroidism and autoimmunity. To much SHBG binds up testosterone. SHBG is the master regulator of testosterone and estrogen. High SHBG levels raises estrogen. Low levels will cause hardening of the arteries and inflammation. Low LDL levels and high tryglicerides. High insulin and high prolaction levels. Can raise estrogen and thyroid hormones. High estrogen and high Thyroid hormones increase SHBG.

ABCB4 if inhibited will inhibit bile. ABC proteins transport molecules across membranes. Phosphatidylcholine is it’s substrate. T3 activates ABCB4,

Cyp7a1 inhibition will inhibit key liver bile enzmes. LXR activators increase Cyp7a1. Taurine enhances Cyp7a1 activity.

IBAT inhibition helps with inflammatory bowel. It improves cholestatic pruritus, helps with biliary cholangitis. It also increases ursodeoxycholic acid which increases bile production.

Increased FGF19 increased bile.

Most with inflammatory bowel have a pyruvate carboxylase deficiency. To increase it phosphatydil choline, biotin, chloroacetic acid which is found in asparagus, red algae and seaweed are needed. Also medium chain fatty acids are needed. Thiamine, phosphate, and magnesium are needed. Read apples and cheese also increase it. Triheptanoin also known as C7 will increase it. This helps restore the citric acid cycle function.

Most with inflammatory bowel have disregulated insulin and glucose levels. Bitter melon taken with sinocrassula indica restore insulin levels and glucose homeostasis.

To break down carbohydrates amylase, brush border enzymes, lactase, maltase, isomaltase, and sucrose activity are required.

SGLT1 deficiency with inhibit glucose absorption causing low glucose levels. This can lead to high ketone levels.

Need to correct issues causing SCFA deficiency and need to reduce branch chain amino acids in obesity but increase them in those who are under weight.

It is very important to reduce estrogen because it increases biounavailable copper. Low oxidizers also have high biounavailable copper. Low oxidizers are usually too alkaline.

Things that help with adrenal fatigue caused by high biounavailable copper is meditation, reduce stress, reduce fear, molybdenum, manganese, selenium, B Vitamins, Vitamin C and vitamin E.

Gut dysbiosis and candida can cause high acetaldehde levels. This can cause you to become intoxicated.

Nad-linked aldehyde removes excess acetaldehyde. ALDH2 gene regulates ALDH.

Other enzymes that remove excess acetaldehyde are adehyde oxidase, xanthine oxidase, glyceraldehyde-3-phosphate dehydrogenase oxidises acetaldhyde. Those who have high acetaldehyde should not use Kudzu it raises acetaldehyde levels. Vitamin B1 is also needed to reduce acetaldehyde. Xylitol inhibits bacteria production of acetaldehyde.

Things that can inhibit enzymes that break down acetaldehyde are biogenic amines, noneal, dopamine, noradrenaline, serotonin, and long chain lipid aldehydes.

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Cancer, what causes it? What may help with it.

Written by Lee Stevenson, sorry I am a lousy editor.

 

This is not medical advice. I am posting this for educational and informational purposes.

These are the notes I compiled together from my friend in our group on Facebook , Synergistic Health. They are an amazing group of people with amazing thinking abilities in my opinion. After ready my friends post and their notes I came to realize that just like diabetes, autoimmunity is not caused by one thing but is a result of a number of things working synergistically to effect the body cancer is also an illness caused by a synergistic effect of a number of things. It also lead me to believe that restoring homeostasis to the things in the body that can contribute to cancer is the best way to recover. An imbalance either direction can contribute to cancer. Most of the things in this article I have posted information on them.

Acidosis and alkalosis are signs of health problems that need addressed. If the health problems causing them aren’t addressed then trying to fight any illness is futile and is like running on a hamster wheel. I have posted on those.

This man tells his story about beating cancer. I have met many who have beat it in a similar way.

https://www.theherbprof.com/Index.htm

Oxidative stress contributes to chronic illness and cancer. You will hear it mentioned often. There is a test for oxidative stress. It is the Urinary 8-OHdG test.

https://www.sciencedirect.com/science/article/pii/S0009898103004534?via%3Dihub

The saddest part of all about cancer is that it is the most profitable of all medical treatments so many doctors have deliberately misdiagnosed people with cancer out of greed.

https://www.healthnutnews.com/more-doctors-confessing-to-intentionally-diagnosing-healthy-people-with-cancer-to-make-money/

Mitochondria regulate our immune response and oxidative stress. Many things can cause mitochondria dysfunction. This can lead to metabolic issues, excess oxidative stress and autoimmunity which can lead to cancer and other chronic illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052888/

There are many problems in cancer research and it leads to many mistakes in their attempts to cure it. The part that frustrates me is the main causes of cancer are things like inflammation, metabolic disorders and autoimmune issues. Instead of trying to correct those and restoring homeostasis they keep looking at the cancer and cannot see the whole picture most of the time. Even in this article they do not mention those things when they talk about the problems in cancer research.

https://www.nature.com/articles/483531a

https://www.hindawi.com/journals/ijcb/2013/639401/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788971/

Cox is found to be high in inflammatory diseases including cancer.

https://www.sciencedirect.com/science/article/pii/S0002961004003587

I believe people are focusing too much on the symptom and not the cause. If they focused on getting the body at homeostasis they would have more success in fighting any chronic illness including cancer. Cancer is a symptom not necessarily the cause of the illness. Science now focuses on the symptoms instead of the cause. I guess this may be because the pharmaceutical industry is the cause of many types of chronic illness and if they looked at the cause they may lose funding from the pharmaceutical industry. Also the biotech industry is owned by the pharmaceutical industry and it is a cause of much of the chronic illness now days. So many researchers are stuck in a hard place, if they looked at the cause they risk losing funding and most likely would lose their jobs.

http://www.detoxifynow.com/real_cause_of_cancer.html

https://vaccineresistancemovement.org/?p=3729

Cancer is usually metabolic illness or autoimmunity and sometimes both. One thing common in most cancers is that it uses glycolysis instead of phosphorylation. Not all cancer uses the Warburg effect some do use oxygen and glucose. What I found common in most cancer is they require and acidic environment to thrive.

https://www.youtube.com/watch?v=2tTg_TeV6Hg&app=desktop

https://medium.com/@drjasonfung/the-paradox-of-cancers-warburg-effect-7fb572364b81

https://highintensityhealth.com/174-angela-poff-phd-cancer-a-metabolic-disease-the-ketogenic-diet-warburg-effect/

https://www.sciencedirect.com/science/article/pii/S1044579X15000991?via%3Dihub

https://www.nature.com/articles/srep04927

https://www.ncbi.nlm.nih.gov/pubmed/24079832

Lactate and the Warburg effect.

https://escholarship.org/uc/item/0m5608vq

Fructose feeds cancer in a different way then glucose does. I do not believe fructose in fruits would do this because natural sources of fructose are usually things that inhibit cancer growth. When things get extracted from a plant and are in their pure form the way they effect the body changes and it acts more like a drug with side effects.

http://cancerres.aacrjournals.org/content/70/15/6368

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622605/

Low thiamine levels can lead to cancer but it can feed cancer that is growing under the conditions involving the Warburg effect.

https://www.sciencedaily.com/releases/1998/06/980623044807.htm

Which explains why beverages high in processed sugar increases the risk for cancer. Processed sugar has also been shown to cause inflammation which has been shown to cause cancer.

https://www.naturalmedicinejournal.com/journal/2010-03/data-clearly-links-soda-consumption-pancreatic-cancer

https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-14-8

Some forms of cancer will decrease when deprived of glucose. Also often times lactic acidosis is present which indicate a health problem that needs addressed. I find it odd that they know what has brought on the cancer but never mention how to address the metabolic or other health issues causing the cancer but they discuss how to treat the symptoms in many studies.

http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003460

https://www.nature.com/articles/sigtrans201647

https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-9-72

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320469/

There are many things they claim are genetic and it is proving to not be true. It is the same with cancer. But many are coming to realize cancer is a preventable disease.

https://www.frontiersin.org/articles/10.3389/fcell.2015.00043/full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2515569/

Some believe it is a metabolic disease, others and autoimmune. I believe it can be either or.

https://www.cancertreatmentsresearch.com/natural-killer-cells-fight-cancer-as-a-metabolic-disease/

Acidosis leads to many forms of chronic illness which can lead to cancer.

http://pancreas.imedpub.com/chronic-metabolic-acidosis-destroys-pancreas.php?aid=164

It is very important to address things that damage the pancrease because it can lead to many forms of chronic illness. When you read these links you will realize that glucose homeostasis is very important. The pancreas regulates our glucose levels so the health of our pancreas is very important for avoiding cancer.

https://fabiosa.com/rser-aulk-every-meal-stomachache-radiating-back-never-suspected-pancreatitis-serious-health-issue-1/?utm_source=fab_philippines&utm_medium=rpost&utm_campaign=ed

https://www.laparoscopic.md/digestion/pancreas

Even the vitamin K shot given to children has been linked to cancer.

https://www.bmj.com/content/305/6849/341

Cancer creates a micro acidic environment.

https://cancerci.biomedcentral.com/articles/10.1186/1475-2867-13-89

Cancer can switch from Warburg effect to OXPHOS in the presence of lactic acidoses which shows the complexity of cancer. It also shows the importance of homeostasis because it seems to grow in extreme conditions like alkalosis and acidosis.

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[0]=9746

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752889/

Oxidative Stress and inflammation contribute to cancer. Most do not see the whole picture, they are seeing the cancer as the cause. Just as with other things they view a symptom as the problem. Cancer just like diabetes or other chronic diseases are a systematic illness. But modern science would expose the fake science behind modern medicine if they looked at the whole picture.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023294/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990475/

Many pharmaceutical drugs increase oxidative stress which increase the risk of cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935272/

Not getting enough sunlight can cause cancer because a person can become deficient in vitamin D.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156047/

https://www.ncbi.nlm.nih.gov/pubmed/24666396

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1524-4741.2008.00571.x?

https://academic.oup.com/jnci/article/97/3/161/2544132

https://www.ncbi.nlm.nih.gov/pubmed/21665065

https://journals.lww.com/pancreasjournal/Abstract/2010/07000/Ultraviolet_B_Irradiance_and_Vitamin_D_Status_are.20.aspx

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579804/

Not enough sunlight increases the risk for prostate cancer.

https://link.springer.com/article/10.1007%2Fs10552-006-0050-6

Not getting enough sunlight even increases the risk of bladder cancer.

https://www.ajpmonline.org/article/S0749-3797(09)00926-X/fulltext

Getting too much sunlight can also have a negative impact on our health and promote cancer. Too much vitamin D in the body can also cause oxalates which can lead to kidneys stones. This is why life guards have some of the highest incidences of kidneys stone formation.

https://www.ncbi.nlm.nih.gov/pubmed/7741122

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873840/

https://www.sciencedirect.com/science/article/pii/S0891584915006061?via%3Dihub

Cancer can be an autoimmune disorder. We know vaccines can cause autoimmunity. This is most likely why cancer rates have taken a dramatic increase.

https://www.ncbi.nlm.nih.gov/pubmed/20223594

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1114674/

https://academic.oup.com/aje/article/167/5/598/211885

https://www.regonline.com/custImages/240000/244811/NCNV%20III/Day%203/Session%209/Keith%20Peden,%20Ph.D..pdf

There are many things that can set off mast cell activation syndrome. It is very important to address whatever is causing it and get the immune system back to homeostasis because excessive mast cell activity can lead to chronic illness and cancer. Mastocytosis is very similar to mast cell activation syndrome and most things that help with MCAS also help with mastocytosis.

https://www.healthcoach7.com/2015/04/16/mast-cells-histamine-friend-or-foe/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715414/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395887/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710302/

Our Cytochrome P450 enzymes protect us from carcinogens. Many things alter the function of our Cytochrome P450 enzyme. There are endocrine disruptor in our food and contains we put food in. Farm chemicals that are found in high levels in our food also disrupt Cyt P450 enzymes. Which can lead to chronic illness and cancer.

Plastic contains many endocrine disruptors.

http://www.herbs-info.com/blog/do-you-know-which-plastics-have-the-highest-cancer-risk/

Loss of Retinoic Acid in the liver can lead to cancer. This shows the importance of reducing oxidative stress and inflammation by addressing the things causing it.

https://www.sciencedirect.com/science/article/pii/S1386634605003128?via%3Dihub

https://www.naturaleyecare.com/articles/vitamin-a-may-shield-former-smokers.asp

There are farm chemicals found in high levels in our foods especially glyphosate and glufosinate. Heavy metals and aluminum can also effect those and our hormones. Aluminum used in vaccines can disrupt many things in the body and lead to cancer. They claim that vaccines do not contain mercury but some vaccines still contain mercury and the ability for it to cause cancer is well known.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018465/

https://www.nature.com/articles/1209377

https://www.ncbi.nlm.nih.gov/pubmed/29250167

https://www.sciencedirect.com/science/article/pii/S0162013413001608

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095782/

https://www.medel.la/card_collections?collection_id=5a458bd369702d428fbd0100

https://thevaccinereaction.org/2017/11/aluminum-in-antiperspirants-linked-to-cancer-and-to-brain-damage-from-vaccines/

https://www.ncbi.nlm.nih.gov/m/pubmed/10472327/

https://beyondpesticides.org/resources/pesticide-induced-diseases-database/cancer

https://truthkings.com/5-vaccines-contain-carcinogenic-glyphosate/

HPV vaccine and cancer.

https://infectagentscancer.biomedcentral.com/articles/10.1186/1750-9378-8-6

https://insights.ovid.com/pubmed?pmid=19155953

https://trenches.wordpress.com/2008/03/14/the-gardasil-scam-hpv-does-not-cause-cancer/

The scariest part is Hela Cells which cause cancer and are very hard to kill were found to be a contaminant in many labs that produce vaccines.

http://www.chicagotribune.com/lifestyles/books/chi-the-immortal-life-of-henrietta-111710-story.html

http://berkeleysciencereview.com/article/good-bad-hela/

https://www.statnews.com/2016/07/21/studies-wrong-cells/

https://www.sciencealert.com/more-than-30-000-scientific-studies-could-be-wrong-due-to-contaminated-undying-cells

Even though these cells were used to develop vaccines I cannot find any research on their safety of being injected into a person. So one would have to conclude since they are an aggressive type of cancer cell and vaccine are most likely contaminated with them then they would contribute to the rise in cancer.

https://vaccinecancerconnection.wordpress.com/2016/08/16/hela-cells-the-continuing-contamination-of-cancer-and-vaccine-research/

Vaccines have been known to cause cancer. I believe it is from the animal tissues used to produce the vaccines along with the toxins contained in them.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666904/

https://www.ncbi.nlm.nih.gov/pubmed/15202523/?ncbi_mmode=std

https://jhu.pure.elsevier.com/en/publications/cutaneous-lymphoid-hyperplasia-and-marginal-zone-b-cell-lymphoma–3

https://www.researchgate.net/publication/43079708_Endogenous_retroviruses_as_potential_hazards_for_vaccines

http://fearlessparent.org/do-vaccines-cause-cancer/

https://www.ncbi.nlm.nih.gov/pubmed/9989448

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906099/

https://mthfrsupport.com/2016/02/more-information-on-gcmaf/

High blood glucose can promote the growth of cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791167/

Some promote hyperbaric oxygen as a solution to fighting cancer. This may work with those that use the Warburg effect but not those that thrive in high oxygen and high glucose environment.

https://beatcancer.org/blog-posts/can-hyperbaric-oxygen-therapy-help-heal-cancer

A disruption in our gut bacteria can lead to chronic illness, metabolic issues and autoimmunity which can lead to cancer. Antibiotics disrupt our gut bacteria and in doing so they increase our risk for cancer.

https://thetruthaboutcancer.com/connection-antibiotic-use-cancer/

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151190

https://detoxproject.org/glyphosate/glyphosate-and-roundup-negatively-affect-gut-bacteria/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784862/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588859/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913328/

http://newsroom.ucla.edu/releases/ucla-research-suggests-that-gut-bacteria-could-help-prevent-cancer#.WMmNDdRYTgQ.facebook

Our gut bacteria even protect us from environmental toxins.

https://www.nature.com/articles/npjbiofilms20163

How antibiotics have been shown to kill many of our beneficial bacteria that protect us from cancer For example Bifidobacterium is one of them. Though antibiotics may kill pathogens that can lead to cancer , they can also kill our good microbes that we need to protect us.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873287/

https://www.ncbi.nlm.nih.gov/pubmed/25811420

http://www.mdpi.com/1420-3049/22/1/107

Fluoride is a known neurotoxin yet they put it in much of the water supply in the U.S. , it is also a carcinogen. Part of it’s carginogenic effects are through it’s effects on our gut bacteria.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132435

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824718/

People were promoting antioxidants for cancer. The problem with that is there are man metabolic issues that if not corrected will cause antioxidants to cause or increase cancer. Those metabolic issues must be dealt with before antioxidants can be used. For example if the Nrf2 pathway is blocked antioxdiants will increase oxidative stress instead of reducing it.

https://www.sciencedirect.com/science/article/pii/S2213231712000110

http://stopcancerfund.org/pz-diet-habits-behaviors/antioxidants-and-cancer-risk-the-good-the-bad-and-the-unknown/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694988/

This study shows the importance of homeostasis. Inhibited Nrf2 pathways can lead to cancer but on the other side of the coin Nrf2 activation can protect cancer. It shows that extremes contribute to cancer we need to try our best to balance things.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684645/

https://onlinelibrary.wiley.com/doi/abs/10.1002/path.4665

In this study they claimed bile acid caused cancer. When I looked deeper into it I found it was a lack of certain gut bacteria that break down the more toxic forms of bile. Not consuming enough fiber which absorbs some of the excess bile and metabolic issues that prevent the body from properly recycling the bile.

https://www.omicsonline.org/bile-acids-promoters-or-carcinogens-in-colon-cancer-2157-2518.1000101e.php?aid=1491

https://academic.oup.com/ajcn/article/102/4/881/4564676

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316202/

Bile acids are also involved in inhibiting cancer. This is why it is important to try and achieve homeostasis. We have to get the idea of killing things out of our heads and learn to support the body so it can do what it was designed to do. There are bile acids that are carcinogenic, our gut bacteria and fiber help reduce those. Also our bodies when functioning properly will recycle bile and reduce the carcinogenic effects. This is why if we have an over production or under production of bile we need to address what is causing it, whether it be from toxins, inflammation, a gut microbiome imbalance or any of the other number of things that can disrupt bile homeostasis.

http://www.jlr.org/content/49/4/763.long

http://www.jimmunol.org/content/198/2/572

This study is pretty much the same they see the symptom instead of the cause they blame the bile acid and not what is causing the bile acid to do what it is.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656903/

https://onlinelibrary.wiley.com/doi/abs/10.1046/j.0014-2972.2001.00938.x

Issues with bile and cholesterol can be caused by inflammaton, infection, or high oxalates among other things. If not addressed it can cause gall bladder disease. This can lead to cancer.

http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:24377514&key=2013.14.11.6257

Cancer as an infection. I have suspected this as a child. I would see people who got diagnosed with cancer take antibiotics and shortly after their cancer would be gone. This stands to reason because some infections cause inflammation and metabolic issues which lead to cancer. We get infections when toxins, vaccine injury or any number of things that effect the immune system occur.

https://jeffreydachmd.com/2016/05/cancer-as-a-parasitic-disease/

https://www.nature.com/articles/bjc2016213

http://jvi.asm.org/content/75/9/4420.long

https://rense.com//general95/lymph.html

http://www.bloodjournal.org/content/107/8/3034.long?sso-checked=true

https://www.karger.com/Article/Abstract/108920

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248167/

https://www.nih.gov/news-events/news-releases/seven-substances-added-14th-report-carcinogens?fref=gc

https://thetruthaboutcancer.com/polio-vaccine-cancer/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207746/

Even now you see studies showing an antibiotic reduces cancer. Problem with that is it disrupts our gut bacteria which is known to cause cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045618/

This study shows that folic acid and B12 can increaste the risk of cancer. This leads me to believe that the person may have problems converting B12. It would build up in the body and studies have shown this increases risk of cancer. This can be corrected with proper nutrients. Also folic acid is different then folate and has been known to cause cancer because the body makes very little of the enzyme needed to break down folic acid. Many have high levels in their bodies because they fortify food with it. It has been shown to increase cancer risk.

https://jamanetwork.com/journals/jama/fullarticle/184898

Substanc P can promote the growth of cancer.

http://www.hh.um.es/Abstracts/Vol_29/29_7/29_7_881.htm

High estrogen levels can promote breast cancer. Phytoestrogens have been shown to inhibit these effects at very high doses but may promote cancer growth at low doses. This is why natural aromatase inhibitors may help.

https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/breast-cancer-and-oestrogen

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129534/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074486/

When I was younger I remember reading many science articles showing when a person got a fever their cancer would shrink. Studies have since shown that a fever reduces cancer. There are natural products that will induce a mild fever.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704862/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312698/

This study shows the importance of homeostasis because in many studies I have read over stimulation of something can cause another form of cancer to develop and completely inhibiting something can cause other forms of cancer to develop. Homeostasis should be the goal because once the body is at homeostasis it will do what it was designed to do and that is to keep us healthy. We achieve homeostasis with proper nutritional support, addressing any metabolic issues, addressing health issues like a deficiency in certain gut bacteria. We should also help support our antioxidant system so that antixodants can do their job. If our antioxidant system is not working then antioxidants will actually increase our oxidative stress. It is very important to reduce inflammation but the body also uses inflammation to tell the body something is wrong and it will stimulate healing. So we do not want to completely block inflammation but reduce excess inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793177/

http://www.budwigcenter.com/full-body-hyperthermia-natural-treatment/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300235/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5096652/

Inhibiting deacetylase can restore the bodies ability to fight cancer. Though I am not keen on using drugs because the side effects on the body can be permanent. This study demonstrates the effects of inhibiting deacetylase.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815979/

Information on the function of histones.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210916/

Cancer can be contagious.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228048/

https://www.cell.com/trends/genetics/fulltext/S0168-9525(15)00187-0

Some viruses have been shown to inhibit cancer like the Zika virus.

http://jem.rupress.org/content/214/10/2843

Child hood infections reduce the risk of getting cancer.

https://www.medical-hypotheses.com/article/S0306-9877(98)90055-X/pdf

https://www.bcm.edu/news/cancer/chicken-pox-may-reduce-risk-of-brain-cancer

http://www.ener-chi.com/articles/how-infection-can-prevent-and-cure-cancer/

http://thinktwice.com/Measles_and_Cancer.pdf

Mumps may prevent ovarian cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951028/

Some viruses attack cancer cells.

https://www.ncbi.nlm.nih.gov/pubmed/20087864

https://www.jstage.jst.go.jp/article/bbb/74/4/74_90787/_article

This is the part that always gets me. Getting infection naturally protects us from cancer. The pharmaceutical industry things they can perfect on something that does not need perfected. If you read this study you will see how ridiculous their theories are on achieving this and how ignorant they are as to how the immune system really works.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926122/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716755/

The flu kills cancer , in this study they claim the flu vaccine also does but at what cost it is the number one cause of vaccine injury. Also vaccinations have been linked to cancer. Vaccinations can cause autoimmunity which has been linked to cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006373/

Cox 2 is found to be high in inflammatory diseases. It can increase the risk of cancer. There are many natural COX inhibitors like resveratrol and querciten.

https://www.nature.com/articles/emm200527

https://www.sciencedirect.com/science/article/pii/S0278691517307524?via%3Dihub

When the spleen gets injured cells can break free and grow accessory spleens. These sometimes get mistaken for cancer.

https://www.ajronline.org/doi/full/10.2214/ajr.183.6.01831653

Lyme disease is often mistaken for cancer.

http://www.zora.uzh.ch/id/eprint/108438/

https://www.ncbi.nlm.nih.gov/pubmed/11401090

Statin drugs increase the risk of chronic illness and cancer.

https://www.westonaprice.org/health-topics/modern-diseases/dangers-of-statin-drugs-what-you-havent-been-told-about-popular-cholesterol-lowering-medicines/

http://ascopubs.org/doi/full/10.1200/jco.2014.58.9564

Toxins can deplete glutathione which will make us more prone to cancer. Toxins can also cause inflammation and immune issues which can result in cancer. Inflammation can also contribute to cancer. High levels of glutathione can prevent the body from eradicating cancer which again stresses the importance of trying to balance things.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051772/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492068/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712330/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673338/

Farm chemicals increases a child’s risk of getting cancer. The sad part of this is that our food supply has been found to be heavily contaminated with farm chemicals. It also increases our risk.

http://cebp.aacrjournals.org/content/7/9/797.long

https://oem.bmj.com/content/68/9/694.long

https://content.iospress.com/articles/cancer-biomarkers/cbm00346

https://www.ncbi.nlm.nih.gov/pubmed/26339156

Glyphosate has been found to contaminate much of our food and water supply.

http://www.i-sis.org.uk/Glyphosate_and_Cancer.php

http://www.amsi.ge/jbpc/11717/25SA16A.pdf

https://people.csail.mit.edu/seneff/SamselSeneffGlyphosateIV.pdf

https://onlinelibrary.wiley.com/doi/abs/10.1016/j.biolcel.2003.11.010

http://www.mdpi.com/1099-4300/15/4/1416

https://www.ewg.org/research/pollution-people#.W15Eix6YXMp

High homocystein levels and low folate levels increases risk of cancer. Folate is natural and should not be mistaken for folic acid which is man made and toxic and has been linked to cancer.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123423

Metabolic issues if not addressed can lead to diabetes, that can lead to cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4737277/

Having the Epstein-Barr Virus increases mortality and increases chances of a negative outcome in chronic illness. There are naturals that inhibit EBV.

https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(15)00306-7/fulltext

Chemo can make cancer spread.

https://news.osu.edu/how-a-chemo-drug-can-help-cancer-spread-from-the-breast-to-the-lungs/

Some infections, vaccine injury , toxins and many other things can cause high B cell levels. This can lead to cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709038/

https://www.sciencedirect.com/science/article/abs/pii/S1043466614002075

Insulin homeostasis is very important in fighting cancer.

http://www.jbc.org/content/290/11/7259.full

Those with cancer should avoid iron. Iron overload or excess iron can feed cancer. Many have been found to have high levels of iron because they fortify foods with iron.

http://www.cacare.com/iron-and-cancer

https://link.springer.com/article/10.1007%2Fs10534-018-0123-5

https://www.pcrm.org/health/cancer-resources/diet-cancer/nutrition/iron-the-double-edged-sword

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995380/

https://breastcancerconqueror.com/can-high-iron-increase-breast-cancer/

Adding to this is G6PD deficiency causes anemia. G6PD deficiency can protect from cancer. Now this is where the pharmaceutical companies would look at the deficiency and try to treat it instead of seeing why the body may be reducing G6PD levels. It is why pharmaceuticals make people sicker while hiding the symptoms. They look at the symptoms as the cause and cannot distinguish between a symptoms and the illness. They view symptoms as illness. G6PD deficiency can also cause cancer because mTOR is upregulated when there is a G6PD deficiency which demonstrates the importance of achieving homeostasis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112277/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797786/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591135/

https://www.sciencedirect.com/science/article/pii/S0925443911001608

Lactate can fuel cancer.

https://www.hindawi.com/journals/mi/2016/6456018/

Lipocalin II inhibits the growth of some cancers but can stimulate the growth of others. Since lipcalin is involved in fighting infection I believe the cancer that is inhibited by lipcalin is most likely an infection. This shows the importance of immune homeostasis.

http://mcr.aacrjournals.org/content/4/11/821

https://onlinelibrary.wiley.com/doi/abs/10.1002/pros.22978

Those with HIV are prone to getting cancer and have low lipocalin levels.

High substance P levels have been linked to cancer.

http://mcr.aacrjournals.org/content/11/3/294

mTOR inhibition has been shown to fight cancer. mTOR homeostasis is very important. It helps protect and repair our DNA. So once we achieve homeostasis we would want to let the body heal.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468516/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154417/

Information on mTOR.

http://jcs.biologists.org/content/122/20/3589

mTOR can interfere with insulin homeostasis which can cause diabetes and cancer.

http://diabetes.diabetesjournals.org/content/early/2017/05/20/db16-1349

How to inhibit mTOR.

https://www.selfhacked.com/blog/mtor-natural-mtor-inhibitors/

Damage to the NMDA receptor has been linked to cancer and diabetes. I have posted on the NMDA receptor.

https://www.dovepress.com/nmda-receptors-are-important-regulators-of-pancreatic-cancer-and-are-p-peer-reviewed-article-CPAA

I thought this was interesting. They experimented with using biophotons to detect cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5699883/

Mesotrypsin has been found to be high in cancer but is difficult to inhibit. It is released from the pancrease to break down typsin inhibiting enzymes found in some foods.

http://www.jbc.org/content/278/49/48580.long

https://link.springer.com/article/10.1007/s10549-009-0699-0

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776145/

http://www.asiaandro.com/Abstract.asp?doi=10.1038/aja.2013.14

https://onlinelibrary.wiley.com/doi/abs/10.1002/pro.2097

http://www.eurekaselect.com/79411

Cathepsin B stimiulates the release of Mesotrypsin. Cathepsin B is also contribues to Alzheimer’s.

http://www.jbc.org/content/276/2/944.long

https://alzped.nia.nih.gov/inhibitors-cathepsin-b-improve

Reducing inflammation may help reduce Cathepsin B.

https://www.tandfonline.com/doi/abs/10.3109/00365513.2011.552631?journalCode=iclb20

There are some natural Cathepsin inhibitors.

https://www.sciencedirect.com/science/article/pii/B9780444637499000062

https://www.researchgate.net/publication/308831242_Chapter_6_Natural_Products_as_Cathepsin_Inhibitors

Fasting reduces Cathepsin B.

https://www.sciencedirect.com/science/article/pii/0304416594901155

SPINK1 protects the pancrease, excess SPINK1 can lead to cancer. This shows the importance of homeostasis because mesotrypsin lowers SPINK1 levels so if you have a disease where you need to incerease SPINK1 you may approach it by decreasing mesotrypsin which is know to cause cancer. Now if we over do it we risk increasing SPINK1 levels to high and increasing our risk of causing cancer. Homeostasis should be the goal.

http://clinchem.aaccjnls.org/content/62/3/449

http://www.jbc.org/content/early/2003/09/24/jbc.M310301200.full.pdf

This shows the importance of reducing oxidative stress and inflammation because it can cause an imbalance in all the above mentioned.

http://www.isca.in/MEDI_SCI/Archive/v1/i2/2.ISCA-IRJMedS-2013-004.pdf

https://www.spandidos-publications.com/ol/7/6/1747

Oxidative stress can deplete MrsA which can make cancer more agressive.

A decrease in MsrA can make cancer more aggressive.
http://www.pnas.org/content/107/43/18628

Infection can upregulate SPINK1

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059459

I usually can find a natural that will resolve issues in the body but this is a tough one and so far only certain pharmaceuticals will work.

https://www.medscape.com/medline/abstract/28463992

Indoleamine 2,3-Dioxygenase is one of the first steps in the production of functional Treg Cells which help regulate the immune system. Excess IDO can inhibit the immune system causing cancer and a deficiency can cause an over active immune response which can cause cancer. Treg cells help kept things at homeostasis. I posted on the immune system and how to raise Treg cell levels. A deficiency in IDO can lead to fibrosis. Now the pharmaceutical industry would inhibit IDO completely causing other forms of chronic illness like diabetes or liver fibrosis which can lead to cancer instead of trying to restore the balance of thing.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012673/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047256/

cancer indoleamine 2,3 dioxygenase

https://www.futuremedicine.com/doi/full/10.2217/imt-2016-0118

Chlorine in water and sunscreens cause cancer.

https://naturalnews.com/2017-07-11-science-shock-chlorine-in-swimming-pools-transforms-sunscreen-into-cancer-causing-toxic-chemical-right-on-your-skin.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974688/

Th17 homeostasis is very important high levels can promote cancer and low levels can increase the risk of getting cancer. Balancing TH17 levels are very important.

https://www.hindawi.com/journals/ecam/2011/548086/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060300/

Metallothonein helps protect us from cancer by reducing oxidative stress caused by toxins. It also helps remove heavy metals from the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634463/

http://www.cease-therapy.com/treatment/metallothionein

https://www.sciencedirect.com/science/article/pii/S0041008X05800171

https://biofoundations.org/inducing-metallothionein-for-heavy-metal-detoxification-and-reducing-oxidative-stress/

Increased insulin like growth factor increases the risk of cancer. By now you should have recognized the pattern you can have to much and too little of the protective enzymes in the body and getting them back to homeostasis should be the goal. If you completely inhibit insulin like growth factor you will cause neurological and brain damage and many other chronic illnesses.

Dairy products can cause high levels of insulin like growth factor.

https://www.pcrm.org/health/diets/vegdiets/health-concerns-about-dairy-products

https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-015-0291-7

https://link.springer.com/article/10.1007/s12032-008-9084-9

Oxidative stress can cause michondria dysfunction which leads to oxidative stress. This can cause a loss of insulin like growth factor.

https://www.sciencedirect.com/science/article/pii/S0925443916300679

http://www.jbc.org/content/274/14/9828.full

https://translational-medicine.biomedcentral.com/articles/10.1186/1479-5876-10-224

Endothelins increase the risk of chronic illness.

https://www.selfhacked.com/blog/endothelins/?utm_source=ActiveCampaign&utm_medium=email&utm_content=The+Latest+From+SelfHacked&utm_campaign=Jan282018+Newsletter

Things that may help.

This is a website of people who beat cancer and the methods they used.

http://www.cancure.org/

Information on spontaneous remission of cancer.

http://library.noetic.org/library/publication-bibliographies/spontaneous-remission

Another website with information about cancer.

http://www.anticancerbook.com/

Functional foods and their role in cancer.

https://www.ncbi.nlm.nih.gov/pubmed/28469951

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527060/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896521/

https://www.sciencedirect.com/science/article/pii/S2215017X15000089

https://academic.oup.com/nutritionreviews/article-abstract/73/7/409/1942256?redirectedFrom=fulltext

http://www.mnwelldir.org/docs/nutrition/diet.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569894/

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1069-1

http://www.lifeextension.com/Magazine/2017/1/Selenium-Impact-on-Cancer-Reduction/Page-01

Vitamins and cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586774/

Many recommend Omega 3 oils to help with cancer. The problem with that if a person has porphyria or Pyrrole disorder fats will make them ill. Those should be corrected before adding Omega 3s to the diet to prevent getting discourage from the negative effects of the fats. This is the part of healing that frustrates me. Instead of addressing what is causing their intolerance to a food they will just avoid the food which prevents them from healing.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418048/

Palmitoylethanolamide is effective against many types of chronic illness. It has been shown to help with cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878779/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878779/

3-bromopyruvate helps stop the Warburg effect which helps stop the growth of cancer. Cancer is usually acidic and creates it’s own micro acidic environment. Since 3-BrPA is an alkalyzing agent which may contribute to it’s effectiveness but it also causes metabolic issues. The problem with allopathic medicine is they do not treat the cause so cancer is bound to occur again. Often times they declare things a success even though the patient dies. For example the patient in this case study died at 18 years old. https://link.springer.com/article/10.1007/s10863-012-9417-4

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176403

https://www.spandidos-publications.com/or/35/3/1287

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329766/

3-BrPA may not be for those who have high levels of ROS because it raises ROS.

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=11592&pubmed-linkout=1

What I have noticed is that the herbs that have a dual effect of fighting pathogens and reduces inflammation seem to be the most effective against cancer.

Ginger has been shown to reduce Cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649839/

https://beatcancer.org/blog-posts/ginger-ten-thousand-times-more-effective-than-chemo-for-breast-cancer-stem-cells

Feverfew reduces cancer. If taken for more then a week it causes toxic withdrawal syndrome that results in severe headaches.

https://www.ncbi.nlm.nih.gov/pubmed/25286681

Infection is known to be mistaken for cancer and has also been shown to stimulate it’s growth. But some types of infection actually reduce cancer.

https://www.sciencedirect.com/science/article/pii/0929693X96811572?via%3Dihub

Self Heal helps reduce cancer.

https://www.ncbi.nlm.nih.gov/pubmed/25331476

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202029/

https://www.worldscientific.com/doi/abs/10.1142/S0192415X12500486?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

Monkey head mushroom helps with cancer.

https://www.karger.com/Article/FullText/480338

Green teas has been shown to fight cancer but taking for too long can have negative health effects like causing the body to produce histamines.

https://www.ncbi.nlm.nih.gov/pubmed/29024813

https://link.springer.com/article/10.1007%2Fs00432-017-2515-2

Oxidative Stress can contribute to cancer. Ketogenic diets help reduce oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102314/

https://news.usc.edu/103972/fasting-like-diet-turns-the-immune-system-against-cancer/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215472/

Amygdalin has been shown to fight cancer. It is found in the pits of some fruits and the bark of wild cherry trees. The problem with most of this research is they purify it removing the nutrients that would be found in it naturally. Purifying anything in nature makes it act more like a drug then a nutrient. High levels of cyanide can be toxic.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320388/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138189/

http://www.ediblewildfood.com/blog/2016/01/b17-amygdalin-for-your-health/

Chronic illness can lead to cancer. A lack of or imbalance of gut bacteria can cause many types of chronic illness from diabetes to mental illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351195/

https://www.hindawi.com/journals/jo/2017/5035371/

https://thetruthaboutcancer.com/gut-flora-cancer-link/

https://www.nature.com/news/gut-microbes-can-shape-responses-to-cancer-immunotherapy-1.22938

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121395/

https://www.frontiersin.org/articles/10.3389/fimmu.2014.00157/full

BT Toxin in genetically modified foods have the ability to cause leukemia.

https://www.omicsonline.org/open-access/hematotoxicity-of-bacillus-thuringiensis-as-spore-crystal-strains-cry1aa-cry1ab-cry1ac-or-cry2aa-in-swiss-albino-mice-2329-8790.1000104.php?aid=11822

H Pylori is commensal and protects us but there is a species of H Pylori that is pathogenic and it often get confused with the commensal one it can lead to cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895553/

Polyphenols reduce oxidative stress and help fight cancer in many other ways.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701397/

Endogenous cannaboids help fight cancer. . Sorry I only have abstracts but it will show the direction they are going.

https://www.ncbi.nlm.nih.gov/pubmed/12746841?dopt=Abstract

https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14331

http://www.pnas.org/content/95/14/8375.long

Incereasing endogenous cannabinoids.

https://medium.com/@mary_c_biles/anandamide-the-bodys-own-antidepressant-and-how-to-boost-it-naturally-895cdafcf7fe

https://www.selfhacked.com/blog/49-ways-increase-natural-cannabinoids-without-smoking-pot-including-ways-decrease-cannabinoids/

https://bebrainfit.com/anandamide/

This is a good article on the cannabinoid system.

https://www.selfhacked.com/blog/the-lectin-sensitive-gene-cannabanoid-receptor-1-genes-cnr1-rs1049353/

A-pinene a cannabinoid found in pine has been shown to fight cancer.

https://www.sciencedirect.com/science/article/pii/S1347861315000110?via%3Dihub

Cannibis can have many side effects.

http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=24625

Cannabinoids can reduce some cancer. I honestly was skeptic about cannabis but have seen many many studies validating it’s effectiveness. I even look for opposing studies and could not find any. Only one involving smoking cannibis.

https://www.ncbi.nlm.nih.gov/pubmed/22198381?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1617062/

https://www.fasebj.org/doi/abs/10.1096/fj.11-198184?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

https://www.sciencedirect.com/science/article/abs/pii/S0006295214004201

http://www.bloodjournal.org/content/100/2/627.long?sso-checked=true

http://cancerres.aacrjournals.org/content/64/6/1943.long

https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/S0014-5793(99)01073-X

http://mcr.aacrjournals.org/content/4/8/549.long

http://cancerres.aacrjournals.org/content/61/15/5784.long

https://www.jci.org/articles/view/16116

https://www.nature.com/articles/onc2008145

https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1476-5381.2012.02027.x

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/?tool=pubmed

Cyclotides found in foods like squashes, violets and the bedstraw family have been shown to fight cancer.

https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201402144

https://www.sciencedirect.com/science/article/abs/pii/S0031942218301006

https://www.sciencedirect.com/science/article/pii/S0367326X15301519?via%3Dihub

Bedstraw also known as cleavers.

http://www.nrcresearchpress.com/doi/abs/10.1139/y11-058?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed#.W13t5B6YXMr

Medium chain fatty acids help fight cancer.

https://www.ncbi.nlm.nih.g

ov/pmc/articles/PMC4394462/

Purslane is a super food it has most nutrients needed by the body. It helps fight cancer in many ways including by modulating the antioxidant system and reducing inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474246/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113926/

Antihistimes in some instances can reduce cancer. But reducing histamines to low can also cause cancer. Homeostasis should always be the goal.

https://www.canceractive.com/cancer-active-page-link.aspx?n=2981

Burdock helps with cancer by reducing toxins and is and antioxidant.

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-11-25

Cannabiol can inhibit cancer but this does not mean it inhibits all cancer. Some cancers can increase with cannabinoid use.

https://www.ncbi.nlm.nih.gov/pubmed/16728591

Fucoidan can inhibit cancer it is found in brown seaweed. It is high in sulfur so if someone had high sulfite levels or sulfation issues, problems with the CBS or BH4 pathways it would most likely increase their cancer because it would add to the toxic levels of sulfites in the body.

https://www.jstage.jst.go.jp/article/bpb/32/10/32_10_1760/_article

http://journals.sagepub.com/doi/abs/10.1177/1534735416680744?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Resveratrol has been shown in many studies to reduce cancer. Alpha-napthoflavone mentioned in the first study is an aromatase inhibitor so would not be good for some to use but those who have high estrogen levels it may help. If a person has high glyphosate or glufosinate levels they would become worse from Alpha-napthoflavone. Glyphosate and glufosinate are aromitase inhibitors. I am not certain I would want to take this route in fighting cancer. It would be better to correct what is causing the high estrogen levels which often times it is a toxin. Resveratrol can activate the hepatitis virus so those with hepatitis may want to avoid it.

https://www.ncbi.nlm.nih.gov/pubmed/29274324

http://www.mdpi.com/1420-3049/23/1/14

Astaxanthin found in krill oil has many health benefits. It has been shown to help fight cancer.

https://www.ncbi.nlm.nih.gov/pubmed/29098031

https://link.springer.com/article/10.1208%2Fs12248-016-0016-x

Astaxanthin really helps naked mice….lol

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367023/

Noon seems to be the best time to get sunlight.

https://link.springer.com/chapter/10.1007%2F978-0-387-77574-6_7

Nutrition and how it effects our chances of getting skin cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637095/

Berberine can reduce cancer by reducing inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425560/

A berry from a type of honey suckle is high in phytochemicals. It is good for many types of chronic illness.

http://biomed.papers.upol.cz/artkey/bio-200702-0001_BERRY_FRUITS_AS_A_SOURCE_OF_BIOLOGICALLY_ACTIVE_COMPOUNDS_THE_CASE_OF_LONICERA_CAERULEA.php

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465088/

Black Sativa helps with cancer and many other health issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387232/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883276/

https://link.springer.com/article/10.1007%2Fs11010-013-1772-x

https://www.sciencedirect.com/science/article/pii/S0006291X12016798?via%3Dihub

Rosemary contains carnosic acid which fights cancer and many other illnesses. Fisetin in found in many fruits and plants. It has been shown to fight many types of illness.

https://www.spandidos-publications.com/ijo/50/6/2123

https://www.sciencedirect.com/science/article/pii/S0009279717307937?via%3Dihub

Small doses of vitamin A reduces cancer, high doses increases cancer risk.

https://www.ebi.ac.uk/interpro/potm/2005_6/Page2.htm

Self Heal helps with cancers caused by high estrogen levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746405/

Phytochemicals found in custard apples inhibit Plasminogen activator inhibitor-1. PAI-1 is found to be high in metabolic disease, inflammatory diseases that cause thrombosis and fibrosis. It has also been found to be high in some types of cancer. Angiotensin II increases PAI-1 there are natural ACE inhibitors that may also help reduce PAI-1.

https://www.nature.com/articles/srep36462

Japanese honeysuckle which is the one with the white and yellow flowers helps with chronic illness by reducing oxidative stress and inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497423/

https://www.hindawi.com/journals/ecam/2015/905063/

How many spices reduce cancer. They help balance the immune system , reduce inflammation and give us micronutrients.

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1381-2

https://www.ncbi.nlm.nih.gov/pubmed/19373612

Coffee reduces the risk of cancer, unfortunately glyphosate has been found to be a contaminate in some coffee and it is carcinogenic through it’s effects on our Cytochrome P450 enzymes, our gut and it’s effects on our hormones so this may not be true now.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036059/

Biacalin is found in sculletaria, fleabane, plantain herb and a few other plants. It has amazing healing benefits and has been shown to help reduce cancer.

https://www.spandidos-publications.com/ijo/47/5/1749

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551355/

Curcumin is a natural Histone deacetylase inhibitor but should be used with caution , it chelates iron and could cause anemia.

http://www.eurekaselect.com/157160/article

Aceroside found in maple syrupt inhibits deacetylase.

https://www.bioportfolio.com/resources/pmarticle/1147611/Aceroside-VIII-is-a-New-Natural-Selective-HDAC6-Inhibitor-that-Synergistically-Enhances.html

HDAC inhitors effects on health.

https://www.researchgate.net/publication/321124642_Therapeutic_Potential_for_Natural_Product_HDAC_Inhibitors_in_Heart_Failure

Diet and phytochemicals effects on DNA.

https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/1868-7083-3-4

Globe Artichoke inhibits cancers.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627240/

Lotus seed has many health benefits. It helps fight cancer.

http://www.mdpi.com/1420-3049/21/11/1465

https://link.springer.com/article/10.1007/s13277-015-4737-8

Moringa is another plant I would consider a super food. It helps fight cancer by helping the body achieve homeostasis.

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-017-1876-z

https://www.ncbi.nlm.nih.gov/pubmed/28705212

http://www.organichealthuniverse.com/2016/08/31/moringa-herb-kills-cancer-stops-diabetes/

Ellagic Acid , helps reduce cancer.

https://jeccr.biomedcentral.com/articles/10.1186/s13046-017-0635-9

http://jpet.aspetjournals.org/content/353/2/433.long

Dandelion had been shown to be very effective against cancer. I believe it is because it does so many beneficial things. It detoxes , it also stimulates DIG1 what will detox many farm chemicals. It provides the body with many nutrients needed for healing and it helps balance the immune system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712354/

https://www.hindawi.com/journals/ecam/2011/129045/

Feverfew contains pathenolide which can induce cell death in cancer. Feverfew is addictive and if taken for a long period of time it will cause toxic withdrawal symptoms which can result in very very severe headaches. It is very effective at fighting infections like the common could and the flu.

https://www.tandfonline.com/doi/full/10.3109/13880209.2014.911919

Beta-Glucan found in many mushrooms improve cell to cell communication and improve immune function which helps the body to fight cancer.

https://www.ncbi.nlm.nih.gov/pubmed/17895634

https://www.cancer.gov/about-cancer/treatment/cam/hp/mushrooms-pdq

http://www.dl.begellhouse.com/journals/708ae68d64b17c52,32c8651274405055,6dc7ca1b3fba21c0.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796484/

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=21411&pubmed-linkout=1

Pomegranate has been shown to reduce cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359844/

Oyster mushroom can help fight cancer.

https://www.liebertpub.com/doi/abs/10.1089/jmf.2006.9.196

Bacopa is amazing for healing, it is really great at healing blog vessels. It has been shown to help with cancer.

http://www.phcog.com/article.asp?issn=0973-1296;year=2017;volume=13;issue=51;spage=595;epage=606;aulast=Mallick

Sodium bicarbonate (baking soda) has been shown to inhibit cancer growth.

https://www.medical-hypotheses.com/article/S0306-9877(13)00347-2/fulltext

https://www.nature.com/articles/sigtrans201647

http://www.wakingtimes.com/2015/07/02/why-oncologists-dont-like-baking-soda-cancer-treatment/

Fasting inhibits cancer growth.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608686/

https://www.healthy-holistic-living.com/scientists-discover-fasting-triggers-stem-cell-regeneration-fights-cancer.html?utm_source=DA&utm_content=9487-F1F8

Fermented wheat germ inhibits cancer growth by depriving it of sugar and stimulating the immune system to attack it.

https://www.naturalnews.com/024484_cancer_wheat_germ.html

Fulvic Acid found in water that has run off from decaying plant matter, organic blackstrap molasses and certain clays can inhibit cancer. It has also been shown to restore cellular autophagy. Some clay sources of fulvic acid can be high in heavy metals.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691117/

Soursop helps fight cancer it has also been found to help with hypertension.

https://steptohealth.com/graviola-natural-miracle-curing-cancer/

Luteolin is another flavonoid that is amazing at it’s ability to heal. It is found in bright colored fruit and vegetables and is very high in the skins of cooked tomatoes.

https://www.spandidos-publications.com/ijo/47/2/747

Honey bee venom reduces cancer. Now this one I set out to prove it was crazy but each study I looked at showed similar results.

http://www.cancerjournal.net/article.asp?issn=0973-1482;year=2017;volume=13;issue=3;spage=544;epage=549;aulast=Mohseni-Kouchesfahani

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=18627&pubmed-linkout=1

Houttuynia helps with cancer.

https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-20-18

Paw Paw helps fight cancer.

http://www.pawpawresearch.com/pawpawworks.html

Mugwort and Wormwood are chemically similar. They have amazing healing properties and are very effective against cancer.

https://www.cancertreatmentsresearch.com/artemisia-annua-its-extract-artemisinin/

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-226

https://www.naturalhealth365.com/wormwood-breast-cancer-2129.html

This is something I noticed. Plants that are good at killing pathogens also have anticancer properties.

https://www.hindawi.com/journals/bmri/2015/735087/

Icariside II found in a number of plants has been found to be effective against cancer by inhibiting mTOR.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053690/

https://www.researchgate.net/figure/Chemical-structure-and-natural-sources-of-Icariside-II-Icariside-II-is-a-major_fig1_280587642

Plantain is another herb with many healing abilities. It has been shown to reduce cancer.

https://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-41113

Vitamin D is important in preventing cancer. There is a lot of debate as to what the highest amounts to be taken should be. I have read many research papers and in doses higher then about 4000 IU it cause oxalates to form. Oxalates are very damaging to the body and can cause cancer. Sources of vitamin D for vegetarians are mushrooms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528277/

Sweetsop helps fight cancer.

https://pubs.acs.org/doi/abs/10.1021/np0704957

Usually I do not list mistletoe but there were many studies showing it’s effectiveness towards cancer. It can be toxic though so I am not sure the benefits a person would get from mistletoe.

https://www.ncbi.nlm.nih.gov/pubmed/27589063

Phytate help fight cancer.

https://www.precisionnutrition.com/all-about-phytates-phytic-acid

I am listing Pakong-Tulog because it has many health benefits including fighting cancer. Though many will not have access to it.

http://www.stuartxchange.org/Pakongtulog

Gymena has many health benefits including inhibiting cancer growth.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912882/

I am not big on pharmaceuticals but Dichloroacetate when used in low doses seems to help with many types of chronic illness including cancer. The problem is the pharmaceutical companies are all about the money so would promote large dose usage to increase profits so as they do with other pharmaceuticals they would recommend extremely high doses.

https://www.sciencedirect.com/science/article/pii/S0304419X14000791?via%3Dihub

https://scienceblog.cancerresearchuk.org/2010/05/12/potential-cancer-drug-dca-tested-in-early-trials/

https://www.spandidos-publications.com/ijmm/42/3/1391

Plants in the mallow family have protective effects on the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590556/

Cat’s Claw helps fight cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384175/

There is a therapy for cancer Antineoplastons taken from urine. I have seen nothing in the studies indicating they are effective or even safe. In my opinion they are useless until I see research proving otherwise.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120064

Sulforaphane found in crudiferous vegetables, onions, garlic and many other foods can ihibit cancer. But those who have high sulfite levels or have CBS or BH4 issues may become sicker and become more prone to cancer. Things like candida, gut dysbiosis, metabolic issues, nutrient deficiencies. High heavy metal levels in the body especially mercury and toxins like glyphosate or glufosinate can cause all those issues I mentioned. So this shows the importance of correcting those issues.

https://www.ncbi.nlm.nih.gov/pubmed/17259330

Elder Berry helps fight cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520748/

Rose Hips has many benefits which would help reduce the risk of cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485961/

Sculletaria contains wogonin and biacelein which have been shown to be effective against cancer.

https://www.hindawi.com/journals/bmri/2017/9381513/

https://onlinelibrary.wiley.com/doi/abs/10.1002/mc.22052

Paeony root helps with cancer.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182584

Trelahose helps with chronic illness including cancer. The way it addresses chronic illnesses is through a number of positive changes that occur in the body when we consume it. Many mushrooms are high in trelahose. There are studies that claim it makes C dif more pathogenic. I was not impressed by the research or convinced by it. GMOs do increase the pathogenicity of C Dif. They never considered that in their research so to me it is invalid because most of our food supply contains GMOs.

http://ar.iiarjournals.org/content/37/11/6133.long

http://www.anti-agingfirewalls.com/2014/06/18/trehelose-a-natural-sugar-that-could-possibly-be-consumed-for-health-and-longevity/

Vitamin K deficiency can inhibit cancer growth which stands to reason because babies that receive the vitamin K shot have a much higher incidence of cancer. This should not be mistaken for vitamin K3 which is much different.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC436974/?page=9

Willow leaves reduce inflammation so it stands to reason they would help with cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779808/

Mammograms are not effective and there are safer and more effective test.

https://www.healthnutnews.com/women-deserve-to-know-the-truth-about-mammograms/

Epimedium contains icariside 2 which inhibits mTOR.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053690/

Milk thistle inhibits mTOR.

https://www.ncbi.nlm.nih.gov/pubmed/26186142

Butryrate found in butter from grass feed beef and produced by our gut bacteria when we eat fiber protects our mitochondria during oxidative stress.

https://www.nature.com/articles/s41398-017-0089-z

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0117851

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070119/

https://paleoleap.com/butyrate-anti-inflammatory-fat/

Enterococcus Lactis protects from cancer.

https://www.frontiersin.org/articles/10.3389/fmicb.2015.01317/full

Our gut microbiome protect us from cancer.

https://www.genengnews.com/gen-news-highlights/microrna-expression-could-be-key-to-leukemia-treatment/81252662

https://www.news-medical.net/news/20130704/Study-shows-miR-22-plays-a-key-role-in-breast-and-blood-cancers.aspx

https://ucdavis.pure.elsevier.com/en/publications/butyrate-induces-ros-mediated-apoptosis-by-modulating-mir-22sirt-

Oligosaccharrides help our gut bacteria produce butyrate.

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000300013

Since amyloid is part of the immune system and cancer can be caused by immune dysfunction it stands to reason that amyloid would be tied to cancer. Have a blog post on amyloid that could compliment this information.

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=7103&path%5B%5D=20217

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=2990&pubmed-linkout=1

https://www.sciencedirect.com/science/article/pii/S0006291X1202390X?via%3Dihub

Crab apple leaves help fight cancer. Regular apple leaves have similar phytochemicals and have been shown to have similar effects.

http://www.mdpi.com/1420-3049/20/12/19754

Hawthorne helps fight cancer.

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-017-1662-y

https://www.ncbi.nlm.nih.gov/pubmed/28277037

https://www.ncbi.nlm.nih.gov/pubmed/26795272

Wild basil helps fight cancer.

http://web.uni-plovdiv.bg/balik/BI0/Clinopodium.pdf

What malberry helps fight cancer.

https://pubs.acs.org/doi/10.1021/acs.jafc.6b01461

http://www.eurekaselect.com/151127/article

Plantain herb helps fight cancer. It has amazing healing properties.

https://www.worldscientific.com/doi/abs/10.1142/S0192415X03000874?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

https://www.sciencedirect.com/science/article/abs/pii/S0753332218300544

Golden Rod helps with colon cancer.

https://www.jstage.jst.go.jp/article/cpb/56/1/56_1_82/_article

Calcium-D-glucururate reduces risk of cancer.

https://www.tandfonline.com/doi/abs/10.3109/09537104.2010.512210?journalCode=iplt20

https://www.hindawi.com/journals/ecam/2015/871832/

https://www.ncbi.nlm.nih.gov/pubmed/12197785

Stinging Nettles fights breast cancer and many other forms of cancer.

https://www.ncbi.nlm.nih.gov/pubmed/28628833

http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:24175819&key=2013.14.9.5317

https://www.ncbi.nlm.nih.gov/pubmed/28544187

https://www.ncbi.nlm.nih.gov/pubmed/27064877

Stinging nettles kills colon cancer cells without harming healthy cells.

https://www.ncbi.nlm.nih.gov/pubmed/27755943

https://www.ncbi.nlm.nih.gov/pubmed/27090648

Boswellia helps fight cancer because it can be cytotoxic so this is an herb that should be used in moderations.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029111/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036794/

Frankinsens and Myrrh fight cancer by restoring immune function.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963062/

High tenascan-c levels increases risk of cancer. High tenascan levels are a sign of injury in the body. It can be from infections, toxins, oxidative stress or many other things that cause damage and inflammation in the body.

http://jcb.rupress.org/content/160/2/171

http://cancerres.aacrjournals.org/content/66/24/11771

When exposed to asbestos B-Catenin is overexpressed. Inhibiting B-Catenin helps with mesothelioma.

https://www.ncbi.nlm.nih.gov/pubmed/29659015

Cardamonin is a natural B-Catenin inhibitor.

https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.12033

https://www.sciencedirect.com/science/article/pii/S2211124716306842

This report has a list of flavinoids that inhibit B-Catenin.

https://www.sciencedirect.com/science/article/pii/S0024320511002220

 

 

 

 

 

Acidosis and the difference between it and Alkalosis.

Acidosis is very serious and results in chronic illness and even death. Symptoms can be difficulty breathing it becomes deeper and more rapid as the body tries to rid itself of CO2 , nausea or vomiting, fatigue, you will be drowsy and sleep a lot, you will become dissociated and get tunnel vision.

https://www.merckmanuals.com/home/hormonal-and-metabolic-disorders/acid-base-balance/acidosis

Acidosis destroys the pancrease which leads to many other forms of chronic illness.

http://pancreas.imedpub.com/chronic-metabolic-acidosis-destroys-pancreas.php?aid=164

One of the differences between acidosis and alkalosis is that nerves become hyper sensitive in alkalosis and we become excitable. In acidosis nerves are depressed and we become drowsy.

http://drbenkim.com/ph-body-blood-foods-acid-alkaline.htm

If not addressed it will result in damage to the pancreas.

http://pancreas.imedpub.com/chronic-metabolic-acidosis-destroys-pancreas.php?aid=164

Acidosis causes hypercalciuria which causes osteoporosis, and kidney stones. It also causes increased levels of vitamin D3 which causes sarcoidosis. Sarcoidosis will cause granulomas to form throughout the body. It often gets mistaken for non alcohol fatty liver and COPD. Sarcoidosis is brought on by an infection and T cells that are out of balance from a result of the acidosis. When in more severe stages the granulomas can be seen under the skin especially around the muscles. This also increase adrenaline which can increase us taking risk and we could develop paranoia.

https://www.ncbi.nlm.nih.gov/pubmed/11416968

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778713/

https://www.medicinenet.com/sarcoidosis/article.htm

Those with acidosis would probably be harmed by aspirin. It can make acidosis worse.

https://derangedphysiology.com/main/core-topics-intensive-care/acid-base-disturbances/Chapter%206.1.9/salicylate-overdose

Acidosis can also be induced by our diet. Our body needs nutrients found in certain fruits and vegetables to regulate our bodies PH. If we eat too much meat and carbohydrates and not enough fruit our blood could become acidic. Our blood is supposed to be alkaline about 7.3 or a little above. When it drops below that we become acidic. The digestive system and bladder are acidic and should be kept at an acidic PH.

https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-9-72

And you guessed it Glyphosate also causes acidosis.

https://www.researchgate.net/publication/299532136_Evidence_that_glyphosate_is_a_causative_agent_in_chronic_sub-clinical_metabolic_acidosis_and_mitochondrial_dysfunction

It can actually switch cancer cells from Warburg effect to OXPHOS phenotype.

http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[0]=9746

https://www.nature.com/articles/srep04927

Acetaminophen can cause acidosis.

https://www.tandfonline.com/doi/abs/10.3109/00498254.2016.1166533?journalCode=ixen20

Sodium bicarbonate prevents cardiac arrest from acidosis.

https://www.jems.com/articles/print/volume-35/issue-12/patient-care/sodium-bicarbonate.html?c=1

Hyperventilating can reduce acid levels but if done improperly can cause a person to pass out so I do not recommend this.

https://insights.ovid.com/pubmed?pmid=23838981

Thiamine deficiency causes increases symptoms of acidosis and gastrointestinal problems.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865064/a

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865064/

Thiamine deficiency can also cause brain swelling.

https://www.psychosomaticsjournal.com/article/S0033-3182(18)30036-7/fulltext

Though acidosis destroys the renal system it can recover at any stage.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081835#s4

Reducing the acidosis with bicarbonate and chelating iron helps fight pathogens.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887168/

https://www.diabetes.co.uk/news/2016/may/baking-soda-could-treat-rare-fungal-infection-in-diabetic-ketoacidosis-98341555.html

Benefits of drinking sodium bicarbonate (baking soda)

https://examine.com/supplements/sodium-bicarbonate/

Kind of ironic I do not like raisins but craved them when I was ill. They help with acidosis.

https://www.organicfacts.net/health-benefits/fruit/health-benefits-of-raisins.html

Metabolic issues cause acidosis especially porphyria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784862/

This is an example of them treating the symptoms but not the cause. Acidosis is a symptoms, but they treat the acidosis instead of figuring out and treating the cause. It is why they did not correct the problem in this experiment. Only 6% of modern medicine is based on science because they are looking at the mind set of thinking the symptoms are the cause. Naturopaths for the most part look for the cause and treat it. That is why they are more successful. Allopathic medicine views successfully treating the symptoms as a success even the the cause is making a person sicker they figure hiding the symptoms is good.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC291975/

Whether a food is acid or base has nothing to do with what it does inside the body. For example lemons are estremely acidic but it cause the body to become more alkaline. I found this list to be some what accurate but the mention a lot of high sulfur foods which should be avoid if you have BH4, CBS issues or high sulfite levels it will make the acidosis worse. Once you have addressed what is causing the acidosis whether it be and infection, toxin, or nutrient imbalance you will not have to worry whether the food alkalizes or not because you body will be able to regulate it’s own ph again.

http://www.altered-states.net/barry/update178/phfoods.htm

In acidosis a person will have high plasma potassium levels and in alkalosis they will have low potassium levels.

https://acutecaretesting.org/en/journal-scans/on-the-relationship-between-potassium-and-acid-base-balance

If we are deficient in magnesium, calcium or salt our body cannot properly regulate our ph levels. Calcium is usually not a problem but because of the myths about salt many have ended up being deficient and there are many deficiencies in minerals because of over farming and glyphosate chelates minerals from the soil.

I believe fasting would be bad with someone who has acidosis because ketones are acidic though I have not found studies to show they raise acidic levels , it would only stand to reason, especially since our body becomes acidic when glucose levels drop.

http://www.silverhydra.com/2011/03/in-defense-of-fasting-why-it-wont-kill-you-and-why-you-should-stfu-until-you-try-it/

As with many types of chronic illness a lack of variety in our gut bacteria causes acidosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801817/

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-016-0171-4

Those with SIBO or gut dysbiosis usually have acidosis. Candida causes alkalosis. This is why increasing bile production is important because if the food ferments from inhibited bile it will increase acidosis.

https://www.theguthealthprotocol.com/wp/d-lactic-acidosis/

http://www.healthy.net/Health/Article/Intestinal_Dysbiosis_and_the_Causes_of_Disease/423

http://www.ichnfm.org/braininflammation5

It is the reason those with dysbiosis have bad breath often times. It is also why after stimulating bile , using chlorophyll reduces bad breath it balances the gut bacteria out restoring the good and killing the bad.

http://mergemedicalcenter.com/uncategorized/halitosis-lies-beneath/

The optimal ph of the large intestine is 6 , in those with acidosis it is around 4 which reduces the good bacteria. I think that is why sipping on a cup of water with half a tablespoon of baking soda in it helped restore my gut. It probably raised the ph of my bowel by reducing the acidity of my chime. As for the alkalinity of the baking soda making H Pylori go from commensal to pathogenic. That would be addressed by bile if you have done things to improve bile production, bile keeps it commensal.

http://msphere.asm.org/content/msph/2/3/e00047-17.full.pdf

Many toxins especially glyphosate and endotoxins can inhibit BH4 that can lead to acidosis so addressing BH4 issues should help. I addressed that in some of my other post if you do a search for BH4 they should come up.

http://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004655&type=printable

In my other post I showed how BH4 becomes uncoupled. This can lead to acidosis , taking the correct nutrient will help correct this problem. If not corrected it can lead to cardiovascular disease.

https://www.researchgate.net/publication/5991066_Myocardial_ischemia_results_in_tetrahydrobiopterin_BH4_oxidation_with_impaired_endothelial_function_ameliorated_by_BHIN4

All the issues caused by toxins and endotoxins lead to acidosis. They inhibit blood flow which farther increases acidosis. That is why I used grape seed extract to thin my blood to improve blood flow. It also reduces inflammation and bradykins.

https://derangedphysiology.com/main/core-topics-intensive-care/acid-base-disturbances/Chapter%208.2.1/lactic-acidosis-sepsis-and-septic-shock