Written by Lee Stevenson. Sorry I am not a very good editor.
This is not medical advice, I am posting this for educational and informational purposes.
People have come to view oxidative stress as a villain but it is needed to remain healthy. It is when oxidative stress reaches levels that cause an imbalance is when it becomes a problem. The key to healing is balancing the antioxidant and oxidative stress systems.
This is a basic description of oxidative stress.
This is a fairly accurate description of oxidative stress but they mention folic acid which is man made and toxic and can build up in the body causing many health problems including cancer. If you take supplements make sure they contain folate not folic acid.
If you want a more in depth explanation this is a good link to follow.
Excess Oxidative stress leads to chronic illness there is a test to see if you have excess oxidative stress. If you do not get it resolved you cannot heal. You can get a test to check oxidative stress levels.
This a small list of illnesses caused by oxidative stress.
Nrf2 is the master regulator of the antioxidant system. Over activation of Nrf2 can cause health problems and if it is inhibited we can experience excess oxidative stress which leads to chronic illness.
Nuclear Factor-Erythroid 2 Related Factor2 (Nrf2) is a major mechanism in the antioxidant system to protect our cells from oxidative and electrophilic stress. The Nrf2 signaling pathway controls the genes that are responsible for the detoxing byproducts of reactive oxygen species (ROS) and and electrophilic reactions. Nrf2 is controlled in part by Keap1 protein. If this pathway becomes blocked many things can happen . It can set of a chain of events because when ROS and the byproducts build up in the body they can severely damage it. The types of damage can be anything from cancer, liver damage, DNA damage and many other things. So the Nrf2 has to be carefully modulated , we do not want it to go to much one way or the other. ROS protects our bodies from toxins and pathogens. So it needs to be tightly regulated because an over abundance can cause severe damage in our bodies and even cause our bodies to start attacking themselves. If the Nrf2 pathway becomes blocked ROS will build up in the body and we lose the ability to detox ROS efficiently. Many neurological issues can be linked to excess oxidative stress.
Nrf2 protects us from oxidative stress by reducing ROS. When byproducts of ROS like hydrogen peroxide are present they signal the induction of the Nrf2 pathway and certain genes are express to deal appropriately with the oxidative stress. If it becomes blocked then the Nrf2 cannot respond to reduce the oxidative stress. There are many things that can cause the Nrf2 to lose it’s ability to reduce oxidative stress. Excess toxins like lead, mercury, fluoroquinolones, fluoride, endotoxins from pathogens, toxins from genetically modified foods , herbicides and pesticides. I could do a whole page on things that can interfere with the proper function of the Nrf2 antioxidant system.
So you can see the importance of Nrf2 in the homeostasis of the redox system and mitochondrial homeostasis. A brief note Nrf2 is also important in reducing inflammation throughout the body.
Glutathione and Nitric Oxide are very important for cell survival of various types. Excess ROS can deplete glutathione and nitric oxide. This can farther inhibit the ability of Nrf2 to respond. This can result in destruction of various tissues throughout the body. It can result in blood clotting, and a break down of the veins throughout the body. So you can see the importance of keeping the Nrf2/Keap1 pathway functioning properly. Without the function of the Nrf2 our bodies cannot protect themselves from many things this can result in cancer and even autoimmune disease. Over activation of Nrf2 can reverse damage from many types of injuries caused by our environment. But over activation has been found to feed some types of cancer, yet over activation can kill other types. That is why we want to achieve homeostasis, with all supplements and foods use moderation. Persistent over activation of Nrf2 has been shown to cause certain type of liver cancer.
If you take antioxidants and the Nrf2/Keap1 pathway is blocked you will increase the ROS in your body. With no way for your body to neutralize the by products and recycle the antioxidant you will increase the toxic loads in your body causing even more damage and increasing your chances of getting cancer.
Gankyrin increase when there is an increase of hydrogen peroxide a byproduct of ROS. Gankyrin competes with Keap1 for binding with Nrf2. This prevents the degradation of Nrf2 causing an excess. This can prevent apoptosis of cancer cells. Gankyrin reduces ROS induced cell damage. Remember I said that ROS is used to protect us. It is used by the body to destroy cancer cells, pathogens, toxins and other things. We need to find a balance and try to reach homeostasis because remember excess ROS also causes cancer and tissue destruction. Reducing oxidative stress and inflammation helps restore gankyrin homeostasis.
Some Nrf2 activators are Alpha Lipoic Acid. ALA is produced by the body, excess oxidative stress causes it to become depleted. It is found in every cell of the body and is an antioxidant also. Some antioxidants work in water and some in lipids (fats). ALA works in both water and oil. It can be replenished in the body by eating red meat high in Omega 9 fatty Acids and brewers yeast. Over consumption of ALA can cause a reduction in blood sugar levels resulting in hypoglycemia, it can reduce thyroid hormones and cause thiamine to become depleted.
Sulforapane is found in cruciferous vegetables like broccoli, cabbage and cauliflower. Cooking them raises the level of sulforopane. If you have sulfation issues they should be addressed or consuming sulfur containing foods will make you ill. It can cause an increase in ammonia and sulfites which are toxic to the body and will increase oxidative stress. High ammonia levels will make our digestive system and bladder alkaline instead of acidic. Restoring the PH of our bladder and digestive system back to acidic is very improtant. Alkaline enviroment makes candida go from commensal to pathogenic. It also creates an environment that is friendly to other pathogens so they can take hold. Gut dysbiois and candida can also increase sulfite levels. CBS and BH4 pathways are effected by sulfation issues and can be upregulated under oxidative stress which would cause them to produce high sulfite levels and could cause us to develop Pyrrole issues(problems with fats) and problems eating meat. We can also develop porphyria. So it is very important to restore Nrf2 homeostais. Pyrrole issues will effect our bile production which then effects digestion issues. Our food will sit and ferment in our guts instead of digesting. This causes many toxins. Pyrrole issues also lead to gall bladder pain and can lead to swelling and infection in the gall bladder. Gall bladder problems will cause pain or burning below the right arm pit.
Cinnamic Acid is found in the bark of many species of cinnamon trees. It has been shown to induce apoptosis of cancer cells. Over use can result in raised oxalate levels.
Tumeric is high in curcumin. Over use can deplete the body of iron and raise oxalate levels. Black pepper causes it’s effectiveness to dramatically increase, so use less if taken with black pepper.
Oleanolic Acid can be found in olive oil, clove, wild rose leaves, honey mesquite and many other plants it is an Nrf2 activator. Salvianic Acid is found in schisandra. Salvianolic Acid is derived from chinese sage also known as red sage. These are also Nrf2 activators.
Redox signaling molecules are also involved in oxidative stress homeostasis. They detect and signal when the body is under oxidative stress and are involved in the bodies response. They are key to our cells response. The signal cell repair or recycling , chelating toxins from the body, cellular autophagy and cell death known as apoptosis. Just as most chronic illness can be linked to Nrf2 they can also be link to the redox system.
This is a description of redox and how it works. This article also discusses ASEA. I looked around the internet and on social media and have seen many positive comments. I cannot find an ingredients list so I cannot decide what I think, I could not find any research that satisfied my questions I had. Seems this person had the same results. So I remain neutral as to what I believe on ASEA.
This is a more detailed description of redox signaling and how it works. This also explains how Nrf2 and redox signaling interact.
This is an interesting report on oxidative stress and it’s effects on the heart. As you learn you will come to realize that LDL is a symptom and not a cause and reducing LDL does more harm then good because cholesterol is an antioxidant.
Antioxidants can reduce oxidative stress if the antioxidant system is working but will increase oxidative stress if there are problems. This is why these problems need to be addressed or else our efforts will be futile.
Toxins and infection can lead to excess NMDA receptor activation which can lead to nitrosative stress.
Redox code is a set of principles that describe redox organization and function.
Redox molecules are involved in DNA repair mechanisms. ROS is involved in redox signaling and oxidative stress. Immune dysfunction can contribute to oxidative stress.
We need oxidative stress but health problems arise when it gets too high.
Not all stress is bad we need eustress to stay healthy. Also how we deal with things can determine if it is unhealthy oxidative stress or healthy eustress. Also too much eustress can be unhealthy.
Intermittent fasting has been an eustressor that has been shown to have health benefits.
Little things matter, even our choice in music can effect how our bodies respond.
Hydrogen Peroxide is a major signaling molecule. There are many things that can cause high levels which can lead to an over production of oxidative stress. This can result in cancer, diabetes, heart disease and many other forms of chronic illness.
I had jobs where the bosses put constant stress on people and would be constantly trying to find reasons to write employees up. They would always be critical of everyone. This caused a high employee turnover. I watched many companies lose money because the wisest and most skilled and efficient workers would leave for jobs that they were more appreciated at. I myself often did that because I noticed it had a negative impact on my health. Most people I worked with welcomed challenges in their jobs but when it became more oppression rather then challenge me and my fellow employees became stressed. When employees are challenged it causes a good type of stress called eustress but when it becomes oppressive the stress effects peoples health negatively.
Stress has a dramatic negative impact on our health and it is why we need to learn to deal with it in a way that will not effect our health .
Exercise is a source of eustress unless we over do it.
Selenoprotein is probably one of the most important molecules in the redox system. They prevent excess oxidative stress, regulate thyroid hormones, help to detox the body, protect the body from inflammation, infection and cancer. A deficiency in selenium makes us susceptible to oxidative stress, chronic illness and dramatically increases our risk for cancer. Selenoproteins and Nrf2 are essential for oxidative stress homeostasis.
Click to access 8b8c1a6149e0e22d6184bf59ee2b446563e5.pdf
Now if you have read the information you will see that high Selenium levels can also cause problems and has been linked to Type 2 diabetes. This shows the importance of homeostasis and not over doing things.
Selenoproteins and their effects on the brain and illnesses linked to them.
SEP15 is involved in protein folding. It is kept in check by Mehionine Sulfoxide reductase. Msr decreases as we age. This results in protein damage. It can also become depleted during excess oxidative stress. Mrs protects from mitochondrial damage.
Increasing Msr may increase life span and quality of life.
A decrease in MsrA can make cancer more aggressive.
Resveratrol, astaxanthan, biacaein, butyrate, selenium, and vitamin D activates 3a(FOXO3a) which activates Mrsa. Those with hepatitis have to avoid Resveratrol it activates the hepatitis virus.
Hemoproteins are another set of redox proteins that are important for detoxing the body, for oxygen transport and many other functions. Inceasing heme increases Hemoproteins. Excess heme raises the risk of cancer and increases oxidative stress. Heme homeostais is very important. Iron is needed for the production of hemoproteins. Too much iron can cause many health problems.
There are others, like iron-sulfur proteins, cupropoteins, flavoproteins, pteroproteins, molybdproteins, manganoproteins. A deficiency in the nutrients needed to produce these proteins or metabolic issues can prevent them from being produced. This disrupts our redox system causing excess oxidative stress.
NAD and NADP systems along with Thiol/disulfide systems are key to the redox code. If there are problems with these then our redox systems ability to function is effected.
You can usually tell what pathways are effected by the symptoms of the illness. This can help guide us to any nutrient deficiencies or metabolic pathways that may be blocked or inhibited.
Excess oxidative stress can rapidly deplete our nutrient supply and can produce endogenous toxins faster then the body can remove them so it is very important to address any health issues and nutrient deficiencies as soon as possible. If we do not then then our immune system is effected and we develop inflammation and immune issues like an imbalance in our T cells. It starts a cycle that is very hard to break. To break the cycle it takes self discipline, learning to pay attention to our bodies and what it is telling us. Also constantly adjusting our protocols as we heal and our bodies needs change. Once our immune system are out of balance and we develop inflammation many metabolic pathways get blocked inhibiting our bodies ability to produce certain enzymes. The body does have alternative pathways but they produce toxins when used. This creates a bigger problem because the inflammation blocks our ability to detox properly. Addressing inflammation and balancing our immune systems are key to reaching homeostasis so we can heal.
Thiols are important in reduce balance. An imbalance in thiol redox can lead to chronic illness, mental illness, neurological damage and many other health problems.
High ROS and RNS levels can oxidize cysteine which leads to inflammation and asthma.
Redox reactions involving thiols.
Molybdenum can become depleted when under extreme oxidative stress. Symptoms of molybdenum deficiency are night blindness, rapid breathing, sulfur sensitivity. Molybdenum is needed to prevent oxidation of thiol groups.
Manganese iron interaction.
So we can see the importance of balancing systems that are dependent on thiols. If there are CBS issues this will effect thiol redox status and needs to be addressed.
BH4 issues can also effect thiol redox. So if we have BH4 issues they should be addressed.
Endotoxins cause BH4 to upregualte to protect the brain. This can result in high sulfite levels in the body which can cause problems.
This can cause BH4 to become depleted if we do not reduce the toxic load. This can lead to cardiovascular disease.
These illnesses can cause sulfite sensitivity , in order to reach redox homeostasis we must address high sulfite levels. With the proper nutrients these things can be corrected. When we are sensitive to sulfites we develop allergies, asthma, food intolerances and if severe enough we can develop many types of chronic illness.
These issues can also be caused by farm chemicals in our food disrupting our gut bacteria. Bile production can be severely impacted. When the bile production is effected, it reduces the production of digestive enzymes in the pancreas which will make food sit and ferment in our stomaches. This makes it feels like we have a brick sitting in our stomach.
Antibiotics cause dramatic changes to the redox system which can lead to chronic illness.
There are many things that can cause haptens. Tick born illness, drugs, toxins especially farm chemicals. Heavy metals can also cause them. If we develop high hapten levels our skin may blister or get rashes similar to a poison ivy rash. If we do not address them it can cause issues with many metabolic pathways.
Some foods are high in sulfites. They are additives in food and can inhibit our beneficial gut bacterias growth.
Hydrogen Sulfide is a redox signaling molecule that can reduce oxidative stress but in excess it inhibits ROS which is also a redox signaling molecule needed by the body. Gut dysbiosis can cause high hydrogen sulfide levels which creates a new set of problems. This can lead to damage to the digestive system. Our guts will become higher in sulfur digesting bacteria. This prevents our food from digesting properly and it will ferment instead. This leads to high levels of Hydrogen sulfide. Hydrogen sulfide can cause hibernation like symptoms and lead to chronic illness. The body only needs a very small amount. If levels get too high we can develop ulcerative colitis, IBD or any other inflammatory gut disease. When our gut bacteria are out of balance and we have too many sulfur digesting bacteria it feels like there is a brick sitting in the gut after we eat. Our guts will bloat out and look like we are pregnant. It is very different then fat because fat is soft when it is bloated out from our food fermenting it will be hard to the touch. When we have a large gut from hormonal issues it will be softer to the touch and usually will saga bit. I have posted information on dealing with these things. If you are dealing with this issue bismuth has been shown to reduce hydrogen sulfide levels. If this occurs we lose our butyrate producing bacteria. Butyrate is needed for gut health , nerve and brain health.
High H2S levels will inhibit heme production which is needed for the production of redox molecule hemoprotein. This can lead to excess oxidative stress and anemia.
Ergothionine is a thiol is found in black beans, kidney beans, bolete and oyster mushrooms and oat bran. Ergothionine protects against oxidative stress, cancer, neurological disease, and improves sensitivity to acetylcholine.
Oxalates have a dramatic effect on the redox system and can be caused to be produced endogenously by toxins like glyphosate, glufosinate, fluorquinolone antibiotics, fluoride, heavy metals. Some foods are high oxalate and should be cooked before eating. Spinach is very high oxalate and I see many people eat it raw. Cooking breaks the oxalates down. Certain metabolic issues can also cause our bodies to produce oxalates. Most metabolic issues can be corrected with the right nutrients.
I don’t mention often N-Acetylcysteine because it is not good for all. Also I noticed that long term use would start having negative effects. So maybe taking it once in a while which is what I did helps but frequent use seems to have the opposite effects. NAC will reduce thiol levels if they are high.
I have friends who are into electronics and love studies like this so I am putting this here for them. It is the electrochemical properties of some vitamins.
The folate cycle is important in redox homeostasis.
If the cause of oxidative stress is not addressed it can deplete thioredoxin reductase. This can lead to neurological damgae.
G6PD protects our blood cells from oxidative stress. Because they lack mitochondria they do not have a back up system for protection. Glyphosate , fluoroquinolones and other toxins can reduce G6PD. Also excess levels of Vitamin C from taking to much in supplements can deplete G6PD. Oxidative stress can deplete G6PD. G6PD is vital to redox balance. They claim some can inherit a defect that causes this but our group on Facebook Synergistic Illness has found many things they claim to be inherited can be linked to vaccine injury, eating habits passed on from family, inherited gut bacteria or many other environmental factors like how we are taught to handle stress.
Many get upset when I do not agree with them taking DHEA. It inhibits G6PD, many things can inhibit G6PD and they could be adding to the problem.
Some may see this study showing high vitamin C levels is good in G6PD deficiency. But the flaw of this study is they did not look at the effects on red blood cells. Studies have shown that high doses of vitamin C break down read blood cells which would defeat the purpose of Vitamin Cs antioxidant effects.
G6PD does help regulate our sugar levels so we do not want levels to get too high. It can also can illness. Homeostasis should always be the goal.
Omega 3 fatty acids help with G6PD deficiency.
What could cause high G6PD levels? Endotoxins which shows the importance of detoxing them.
Catalase reduces ROS. Most plants that contain it also are high in sulfur so those with sulfation issues need to avoid high sulfur foods until they have addressed their high sulfite leves. There are plant sources of catalase that are not high sulfur if you do your research.
Hawthorne leaves and berries have many health benefits they also help reduce lung inflammation.
It also helps regulate the antioxidant response.
Wild Basil helps reduce oxidative stress and inflammation. Most spices contain similar phytochemicals so this is true for many spices.
Galinsoga reduces oxidative stress.