Health hazards of EMFs.

antenna-blue-sky-cell-tower-94844

This is not health advice, I am posting this for informational purposes only.

Written by my Facebook friend Matt Murtaugh. I know how exhausting it is to research things and to put the information together. It has taken me 50 hours and sometimes more to do post like this. Thank you Matt, we appreciate your hard work.

EMFs (Electromagnetic fields) or EMRs (Electromagnetic radiation) has become big parts of our lives. Many are unaware of risks and believe they would know if there were any, but there are many studies bringing EMF’s safety in question. With the rollout of 5G, it will increase our exposure, and regulators are not erring on the side of caution. The precautionary principle must be exercised. Towards 5G communication systems: Are there health implications?

https://www.sciencedirect.com/science/article/pii/S1438463917308143?fbclid=IwAR1dF245KqqNZRrZOVYQi35mOvZE7orZHoGdukneu4yAsaO9znUBTx0GHIY

“In this evolving scenario, although the biological effects of 5G communication systems are very scarcely investigated, an international action plan for the development of 5G networks has started, with a forthcoming increment in devices and density of small cells, and with the future use of millimeter waves (MMW). Preliminary observations showed that MMW increase skin temperature, alter gene expression, promote cellular proliferation and synthesis of proteins linked with oxidative stress, inflammatory and metabolic processes, could generate ocular damages, affect neuro-muscular dynamics.” Wi-Fi is an important threat to human health

https://www.sciencedirect.com/science/article/pii/S0013935118300355

“Repeated Wi-Fi studies show that Wi-Fi causes oxidative stress, sperm/testicular damage, neuropsychiatric effects including EEG changes, apoptosis, cellular DNA damage, endocrine changes, and calcium overload.” Biological effects from electromagnetic field exposure and public exposure standards. “Health endpoints reported to be associated with ELF and/or RF include childhood leukaemia, brain tumours, genotoxic effects, neurological effects and neurodegenerative diseases, immune system deregulation, allergic and inflammatory responses, breast cancer, miscarriage and some cardiovascular effects.”

https://www.ncbi.nlm.nih.gov/pubmed/18242044

Study showing as little as 2 hours of screen time effects brains

https://www.thisisinsider.com/how-screen-time-affects-childrens-brains-nih-study-2018-12?fbclid=IwAR0w6GwUccVBjUinFeP3Z0Qep2k7_Ao52dLwcbizeuXAlpmEn6dJpwoNVBE

Evidence that dirty electricity is causing the worldwide epidemics of obesity and diabetes

http://www.sammilham.com/small%20islands%20diabetes%20and%20obesity%20-%20Copy%20(2).pdf

Adult and childhood leukemia near a high-power radio station in Rome, Italy

https://www.ncbi.nlm.nih.gov/pubmed/?term=Adult+and+childhood+leukemia+near+a+high+power+radio+station+in+Rome%2C+Italy

Cluster of breast cancer in men who worked near an electrical switchroom

https://www.ncbi.nlm.nih.gov/pubmed/?term=A+cluster+of+male+breast+cancer+in+office+workers

Could ALS be caused by electrical devices?

http://www.sammilham.com/Amyoptrophic%20lateral%20sclerosis%20(Lou%20Gehrig’s%20disease)%20and%20electric%20currents.pdf

Cluster of testicular cancer in police officers exposed to hand-held radar “Occupational use of hand-held radar was the only shared risk factor among all six officers, and all routinely held the radar gun directly in close proximity to their testicles.”

https://www.ncbi.nlm.nih.gov/pubmed/?term=Cluster+of+testicular+cancer+in+police+officers+exposed+to+hand-held+radar

Magnetic field exposure in relation to leukemia and brain cancer mortality among electric utility workers.

https://www.ncbi.nlm.nih.gov/pubmed/7817968

Brain cancer risk increased by an estimated factor of 1.94 per microtesla-year of magnetic field exposure in the previous 2-10 years, with a mortality rate ratio of 2.6 in the highest exposure category. In contrast to other studies, these data do not support an association between occupational magnetic field exposure and leukemia but do suggest a link to brain cancer. Leukaemia, brain tumours and exposure to extremely low frequency magnetic fields: cohort study of Swiss railway employees.

https://www.ncbi.nlm.nih.gov/pubmed/17525094

“Some evidence of an exposure-response association was found for myeloid leukaemia and Hodgkin’s disease, but not for other haematopoietic and lymphatic malignancies and brain tumours.” Melanoma Incidence and Frequency Modulation (FM) Broadcasting

http://media.withtank.com/eec46e2c2f.pdf

“The results from this analysis support the findings of Dolk and show that melanoma incidence is correlated related with public FM broadcasting not only on a local scale, but also for entire countries.” Increased incidence of cancer in a cohort of office workers exposed to strong magnetic fields.

https://www.ncbi.nlm.nih.gov/pubmed/?term=ncreased+incidence+of+cancer+in+a+cohort+of+office+workers+exposed+to+strong+magnetic+fields

“A positive trend of cancer cases with duration of employment is seen for males and females separately and together” Increased mortality in amateur radio operators due to lymphatic and hematopoietic malignancies.

https://www.ncbi.nlm.nih.gov/pubmed/3422125

“a statistically significant increased mortality was seen for cancers of the other lymphatic tissues” Cancer incidence and mortality and proximity to TV towers

https://www.ncbi.nlm.nih.gov/pubmed/?term=Cancer+incidence+and+mortality+and+proximity+to+TV+towers

“We found an association between increased childhood leukaemia incidence and mortality and proximity to TV towers.” Most cancer in firefighters is due to radio-frequency radiation exposure not inhaled carcinogens

https://www.sciencedirect.com/science/article/pii/S0306987709002886

“Firefighters have increased exposure to RFR in the course of their work, from the mobile two-way radio communications devices which they routinely use while fighting fires, and at times from firehouse and fire vehicle radio transmitters. I suggest that some of the increased cancer risk in firefighters is caused by RFR exposure, and is therefore preventable. The precautionary principle should be applied to reduce the risk of cancer in firefighters, and workman’s compensation rules will necessarily need to be modified.” Dirty electricity elevates blood sugar among electrically sensitive diabetics and may explain brittle diabetes. “Dirty electricity, generated by electronic equipment and wireless devices, is ubiquitous in the environment.” – In other words, dirty electricity is directly linked to diabetes. Diabetes is an epidemic today.

https://www.ncbi.nlm.nih.gov/pubmed/18568931

A New Electromagnetic Exposure Metric: High Frequency Voltage Transients Associated With Increased Cancer Incidence in Teachers in a California School

http://www.sammilham.com/La%20Quinta%20Middle%20school%20teachers’%20cancers.pdf

“The cancer incidence in the teachers at this school is unusually high and is strongly associated with exposure to high frequency voltage transients. In the 28 years since electromagnetic fields (EMFs) were first associated with cancer, a number of exposure metrics have been suggested. If our findings are substantiated, high frequency voltage tran-sients are a new and important exposure metric and a possible universal human carcinogen similar to ionizing radiation.” Proteomic analysis of continuous 900-MHz radiofrequency electromagnetic field exposure in testicular tissue: a rat model of human cell phone exposure.

https://www.ncbi.nlm.nih.gov/pubmed/28397118

“Our results indicate that exposure to RF-EMF produces increases in testicular proteins in adults that are related to carcinogenic risk and reproductive damage. In light of the widespread practice of men carrying phones in their pockets near their gonads, where exposures can exceed as-tested guidelines, further study of these effects should be a high priority.” A 1000 Mhz is equal to 1 G. So a phone on 5G is 5x the 900 Mhz amount.

“Triple M” Effect: A Proposed Mechanism to Explain Increased Dental Amalgam Microleakage after Exposure to Radiofrequency Electromagnetic Radiation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928305/

“Dental amalgam fillings have been used in restorative dentistry for more than 150 years. There are reports which indicate that exposure of amalgam to RF-EMFs can lead to accelerated microleakage of amalgam.” US patent on Nervous system manipulation by electromagnetic fields from monitors

http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=6506148.PN.&OS=PN/6506148&RS=PN/6506148

“Many computer monitors and TV tubes, when displaying pulsed images, emit pulsed electromagnetic fields of sufficient amplitudes to cause such excitation. It is therefore possible to manipulate the nervous system of a subject by pulsing images displayed on a nearby computer monitor or TV set. For the latter, the image pulsing may be imbedded in the program material, or it may be overlaid by modulating a video stream, either as an RF signal or as a video signal. The image displayed on a computer monitor may be pulsed effectively by a simple computer program. For certain monitors, pulsed electromagnetic fieldsbcapable of exciting sensory resonances in nearby subjects may be generated even as the displayed images are pulsed with subliminal intensity.” Microwave frequency electromagnetic fields (EMFs) produce widespread neuropsychiatric effects including depression

https://www.sciencedirect.com/science/article/pii/S0891061815000599

“Non-thermal microwave/lower frequency electromagnetic fields (EMFs) act via voltage-gated calcium channel (VGCC) activation. Calcium channel blockers block EMF effects and several types of additional evidence confirm this mechanism. Low intensity microwave EMFs have been proposed to produce neuropsychiatric effects, sometimes called microwave syndrome, and the focus of this review is whether these are indeed well documented and consistent with the known mechanism(s) of action of such EMFs.” Hippocampal lipidome and transcriptome profile alterations triggered by acute exposure of mice to GSM 1800 MHz mobile phone radiation: An exploratory study.

https://www.ncbi.nlm.nih.gov/pubmed/29786969

“This study provides preliminary evidence that mobile phone radiation induces hippocampal lipidome and transcriptome changes that may explain the brain proteome changes and memory deficits previously shown by our group.”Understanding physical mechanism of low-level microwave radiation effect.

https://www.ncbi.nlm.nih.gov/pubmed/29775391

“The cumulative impact of coherent MW field in a medium has been convincingly confirmed by the measurable dielectric permittivity of the medium. The described mechanism of MW field-induced effect confirms that the nature of the effect differs from the thermal effect and that the exposure by MW radiation can create the specific consequences in biology and materials not characteristic for conventional heating.” Long-term exposure to 835 MHz RF-EMF induces hyperactivity, autophagy and demyelination in the cortical neurons of mice -Mhz are below Gs. So if a phone is running on 5G, it’s nearly 5x the 825 MHz.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247706/

“Importantly, we found that RF-EMF exposure led to myelin sheath damage and mice displayed hyperactivity-like behaviour. The data suggest that autophagy may act as a protective pathway for the neuronal cell bodies in the cerebral cortex during radiofrequency exposure. The observations that neuronal cell bodies remained structurally stable but demyelination was induced in cortical neurons following prolonged RF-EMF suggests a potential cause of neurological or neurobehavioural disorders.” Effect of Lycopersicon esculentum extract on apoptosis in the rat cerebellum, following prenatal and postnatal exposure to an electromagnetic field In other words chronic exposure is worse than short term. And lycopene was helpful here.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3735912/

“This indicated that chronic EMF exposure had a greater apoptotic effect on the cerebellar cells than short-duration exposure, even at the same frequency.” “These results indicate that the antioxidant, lycopene, protects against trimethyltin-induced neurotoxicity by inhibiting the ROS-initiated mitochondrial apoptotic pathway.” Effect of mobile telephones on sperm quality: a systematic review and meta-analysis.

https://www.ncbi.nlm.nih.gov/pubmed/24927498

“We conclude that pooled results from in vitro and in vivo studies suggest that mobile phone exposure negatively affects sperm quality.” Does prolonged radiofrequency radiation emitted from Wi-Fi devices induce DNA damage in various tissues of rats?

https://www.ncbi.nlm.nih.gov/pubmed/?term=Does+prolonged+radiofrequency+radiation+emitted+from+Wi-Fi+devices+induce+DNA+damage+in+various+tissues+of+rats%3F

“However the increase of the DNA damage in rat testes tissue was significant” “The results of this study indicated that testes are more sensitive organ to RF radiation.” Male fertility and its association with occupational and mobile phone towers hazards: An analytic study

https://www.sciencedirect.com/science/article/pii/S1110569016300127

“Quality of semen might be affected by occupational and environmental exposures, so it seems that prevention of occupational and environmental risk factors, may lead to improvement of semen quality in subfertile men.” Electromagnetic Fields, Pulsed Radiofrequency Radiation, and Epigenetics: How Wireless Technologies May Affect Childhood Development.

https://www.ncbi.nlm.nih.gov/pubmed/28504324

“Symptoms of retarded memory, learning, cognition, attention, and behavioral problems have been reported in numerous studies and are similarly manifested in autism and attention deficit hyperactivity disorders, as a result of EMF and RFR exposures where both epigenetic drivers and genetic (DNA) damage are likely contributors. Technology benefits can be realized by adopting wired devices for education to avoid health risk and promote academic achievement.” Low intensity microwave radiation induced oxidative stress, inflammatory response and DNA damage in rat brain.

https://www.ncbi.nlm.nih.gov/pubmed/26511840

“In conclusion, the present study suggests that low intensity microwave radiation induces oxidative stress, inflammatory response and DNA damage in brain by exerting a frequency dependent effect. The study also indicates that increased oxidative stress and inflammatory response might be the factors involved in DNA damage following low intensity microwave exposure.” Radiofrequency radiation emitted from Wi-Fi (2.4 GHz) causes impaired insulin secretion and increased oxidative stress in rat pancreatic islets.

https://www.ncbi.nlm.nih.gov/pubmed/29913098

“These data showed that EMR of Wi-Fi leads to hyperglycemia, increased oxidative stress, and impaired insulin secretion in the rat pancreatic islets.” Effects of pulsed electromagnetic fields on cognitive processes – a pilot study on pulsed field interference with cognitive regeneration.

https://www.ncbi.nlm.nih.gov/pubmed/15180806

“We could show that the participants’ cognitive performance was impaired after exposure to pulsed electromagnetic fields. With regard to this finding, we recommend that the use of cellular phones should be restricted generally and in particular in respect of physical hazard of high-risk groups, e.g. elderly, children and ill people.” Absorption of wireless radiation in the child versus adult brain and eye from cell phone conversation or virtual reality.

https://www.ncbi.nlm.nih.gov/pubmed/29884550?fbclid=IwAR1ppG8iWrLdHRsUDJXU61NctCBFwt98xP4ahUTu6tOmmZHRJS7t74e3J0E

“Modeling of a cell phone held to the ear, or of virtual reality devices in front of the eyes, reveals that young eyes and brains absorb substantially higher local radiation doses than adults’.” Mobile phone use and risk for intracranial tumors and salivary gland tumors – A meta-analysis

https://www.ncbi.nlm.nih.gov/pubmed/28220905

“The results support the hypothesis that long-term use of mobile phone increases risk of intracranial tumors, especially in the case of ipsilateral exposure.”

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Causes of hypertension and things that may help.

This is not medical advice I am posting this for educational and informational purposes.

heat

 

Homeostasis should always be the goal we need balance. Some things in low levels improve health and in high levels they would impact our health negatively.

First hypertension and atherosclerosis are symptoms of an underlying illness that is causing endothelial dysfunction. Hypertension and atherosclerosis are endothelial dysfunction and to stop it and reverse it you have to find the cause.

Hypertension and atherosclerosis is actually endothelial dysfunction. There are many errors in this they see the symptoms as the cause of the illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993955/

What causes arterial plaque.

https://www.lifeextension.com/Magazine/2008/10/Natural-Methods-for-Reversing-Atherosclerosis/Page-01

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424816/

https://www.lifeextension.com/Magazine/2017/5/Arterial-Plaque-Rupture/Page-01

http://www.heart.org/en/health-topics/cholesterol/about-cholesterol/atherosclerosis

https://www.sciencedirect.com/science/article/pii/S0735109709004446

Inflammation causes atherosclerotic lesions which cause foam cells to form which adds to the inflammation and can lead to blood clotting. This inflammation can be caused by infection or toxins. This is a result of the of BVDL, AcVDL, and oxLDL which are formed from the up regulation of the LXR and RXR upregulation and overexpression.

https://onlinelibrary.wiley.com/doi/full/10.1002/9780470015902.a0020730.pub2

Ly6c inflammatory monocyte and their conversion to M2 monocyte drives atherosclerosis regression. STAT6 is required for the conversion.

https://www.jci.org/articles/view/75005

I should mention foam cells. That is in the later stages of atherosclerosis and is what leads to blood clotting, stroke and cardiac arrest.

https://www.sciencedirect.com/science/article/pii/S0009898113002477?via%3Dihub

https://www.sens.org/outreach/conferences/oxidized-lipids-atherosclerotic-macrophages-what-role-do-they-play-foam-cell

https://www.cell.com/cell-metabolism/pdf/S1550-4131(05)00084-7.pdf

This gets deep into lipid and cholesterol metabolism if a person desires to get a deep understanding of cholesterol and how atherosclerosis may occur. I seen many inaccuracies in this though.

https://www.sciencedirect.com/science/article/pii/S0008874918300327?via%3Dihub

This is a blog of a doctor who discusses his observations of heart disease over the years.

https://drmalcolmkendrick.org/

There are many things that cause hypertension. It is not high cholesterol or a high fat diet contrary to what they say those things help prevent hypertension. It is balancing those things that matter when it comes to hypertension. Infection, inflammation, stress, nutrient deficiencies, oxidative stress, consumption of too much processed sugar , artificial sweeteners , leaky gut, metabolic issues, toxins like farm chemicals found in our foods especially glyphosate, and an imbalance in our gut bacteria caused by toxins and antibiotics can lead to hypertension.

Many supplements can help with the symptoms but the underlying cause of hypertension still needs addressed and corrected.

Many things they claim are genetic are actually life style or gut microbiome that was inherited and not genetics. I have seen many correct health issues by making the right adjustments in life style and their microbiome. I have also seen some who took the wrong probiotic and added to their health problems. Before taking probiotics a person needs to fully educate themselves on things. Hypertension is a symptoms it is not the illness. I am not going to cover weight loss in this post. Most weight gain indicates an underlying health problem. I posted on the causes and what may help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146775/

https://draxe.com/high-blood-pressure-symptoms/

https://drhoffman.com/article/alternative-approaches-to-hypertension-2/

http://drflannery.com/the-functional-medicine-approach-to-high-blood-pressure/

https://www.sciencedirect.com/science/article/pii/S0041008X13000549

Many medical professionals are starting to speak out about the true cause of heart disease.

https://www.healthy-holistic-living.com/heart-surgeon-speaks-true-cause-heart-disease.html?utm_source=TT&utm_content=49524-E423

Fluoroquinolones contribute to heart disease. Many drugs can cause heart disease.

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2451282?utm_source=facebook&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=031817#.WMy_0xVcIlw.facebook

https://www.bmj.com/content/349/bmj.g6196

https://floxiehope.com/2017/11/02/fluoroquinolones-increase-expression-of-mmps/?fbclid=IwAR2c264L9Butl5LnDGIrYa0UeDINEutAM4Gf-3BBUkcPRrEa-7jSMjKBO7o

https://www.drugnews.net/news/why-did-novartis-hide-tasigna-warnings-from-united-states-patients/?fbclid=IwAR06bRjTkc_lwmJuODPUZ9IAzYr5rfuQ-LBofDSRyFSYJf0u8WuaeXJLq_E

This is a very good video on why hypertension should not cause the panic it does and why people develop hypertension.

https://www.youtube.com/watch?v=GizDuANT9BE

Inflammation causes hypertension and high transglutamase levels can cause hypertension.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861548/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015405/

https://www.ahajournals.org/doi/abs/10.1161/jaha.117.005729

https://academic.oup.com/ajcn

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590813/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082111/

High C-reactive protein levels causes inflammation. It can be caused by infection and toxins. This can lead to cardiovascular disease. Or eating a lot of processed foods.

https://www.healthline.com/health/c-reactive-protein

https://jeffreydachmd.com/2015/09/low-level-endotoxemia-depression-endocrinopathy-and-coronary-artery-disease-by-jeffrey-dach-md/

Diabetes and heart disease is symptoms of an underlying health issue. I have posted on diabetes and the causes. The end result is endothelial dysfunction which can be corrected by reducing inflammation and oxidative stress. I have also posted on those.

https://www.hindawi.com/journals/ijvm/2012/918267/

http://www.scielo.br/scielo.php?pid=S1516-84842010000600013&script=sci_arttext&tlng=en

https://cardiab.biomedcentral.com/articles/10.1186/1475-2840-4-5

Urinary marker for oxidative stress. I have posted on oxidative stress and there are other detection methods.

https://www.sciencedirect.com/science/article/pii/S0009898103004534?via%3Dihub

Oxidative stress , endocannabinoid system and atherosclerosis.

https://www.mdpi.com/2305-6304/3/4/481/htm?fbclid=IwAR1AJt9sN3lFzu-eSMm_YJzkd4dmIputB2kknOeENKtUukFwRg02fnhnASc

Glyphosate which has been found to be high in most of our food supply is one of the number one contributors to high glutamase levels. This cause gluten sensitivity. Glyphosate and antibiotics dysrupt our gut microbiome which can lead to celicac disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/

https://www.researchgate.net/publication/309145804_Gut_Microbiota_and_Risk_of_Developing_Celiac_Disease/download

Inhibiting IL-6 can help with hypertension. IL-6 increases inflammation and is stimulated by infection and injury. IL-6 levels can be raised by infection especially tick born illnesses like Lyme disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176007/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843869/

https://academic.oup.com/cardiovascres/article/114/11/1547/5001804

https://www.ncbi.nlm.nih.gov/pubmed/9222183

https://academic.oup.com/jid/article-pdf/178/5/1512/2426868/178-5-1512.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797759/

https://www.ashjournal.com/article/S1933-1711(14)00651-2/abstract

https://www.nejm.org/doi/10.1056/NEJMoa1707914

Most know that peridontal disease has been linked to hypertension.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403746/

Infection and oxidative stress can cause high plasma ceremide levels which can lead to cardiovascular disease.

http://medprofvideos.mayoclinic.org/videos/plasma-ceramides-a-novel-biomarker-of-unstable-atherosclerotic-cardiovascular-disease?fbclid=IwAR3hTjRvPVn_J2zWrDUEkQFLp9rVMF3Yp7p4FmD7atH1QuAcKv1D4vXCtbE

Vaccination has been linked to hypertension.

http://www.eurekaselect.com/103584/article

https://www.ncbi.nlm.nih.gov/pubmed/21781156

https://www.ncbi.nlm.nih.gov/pubmed/20964738

https://www.sciencedirect.com/science/article/pii/S107858841000064X?fbclid=IwAR13KNOnz89iCUOQymWBQxhlhqg_a_D2-w3qU7EgRiBFT08Bhq_86dUWFjw

Vaccines also cause autoimmunity which has been linked to cardiovascular disease.

https://www.sciencedirect.com/science/article/pii/S107858841000064X?fbclid=IwAR1GIryUMPvHN6DOYMoJiKgJv-Y07WY9WoobmOldmCHMRMOjMbbfU1bLKhE

Information on aldosterone which helps regulate sodium and potassium levels in the body.

https://www.selfhacked.com/blog/need-know-aldosterone-health-effects/

Dangers of too much potassium.

https://healthyeating.sfgate.com/dangers-much-potassium-body-4817.html

Cox inhibition cause salt induced hypertension.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639986/

As for salt itself causing hypertension that myth has been busted many times.

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009217/abstract

UMOD overexpression can cause salt induced hypertension. UMOD overexpression is a sign of urinary infection.

https://www.nature.com/articles/nm.3384?fbclid=IwAR2FNSD6ylOCc0J_I_Jq_hf1t3oz1ZckN9CYKrKpTDENGbD3xeqnnsMw4Uk

https://www.karger.com/Article/PDF/321013

UMOD overexpression is also a sign of kidney injury which can be caused by oxidative stress, nutrient deficiency, bad life style, toxins, farm chemicals like glyphosate even vaccine injury or autoimmunity.

https://www.sciencedirect.com/science/article/pii/S0272638611016982

HSP70 can help with those who are sensitive to salt. It can help with salt induced hypertension. I have posted on HSP70. It also prevents thrombosis.

https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14334

https://academic.oup.com/cardiovascres/article/110/3/309/1744740?searchresult=1

https://www.selfhacked.com/blog/heat-shock-proteins-hsp70-increase-decrease/

Low sodium diet could have a negative impact on health.

https://articles.mercola.com/sites/articles/archive/2017/12/03/low-sodium-effects-on-health.aspx

Inhibiting Caveolin-1 helps with hypertension. High Caveolin-1 levels are caused by infection and sepsis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145768/?fbclid=IwAR3QVaIdtlH958NPB_Bme8Xcz-h3IznfrVpoYpE640pEHrqzwNQRHictPuI

https://www.sciencedirect.com/science/article/abs/pii/S0024320514006365

https://www.ncbi.nlm.nih.gov/pubmed/26618071

https://www.nature.com/articles/s41419-018-0795-3

Salt craving is often a sign of mineral deficiency that is why sea salt can help reduce blood pressure because it can reduce the craving for salt because it has many minerals in it.

http://foods-that-lowerbloodpressure.com/2011/salt-and-hypertension-sea-salt-to-lowerblood-pressure?fbclid=IwAR1zqUYA9j6k8vU0S-_jU_MZ-9hjJtR87eO0b-Pnlp71WtXC6EZLp_MPj3Q

Those who have issues with salt may benefit from diuretic foods. But do not over do it. Flushing to many fluids from the body can actually cause high blood pressure from being dehydrated and from and electrolyte imbalance.

https://healthwholeness.com/diuretic-foods?fbclid=IwAR09IbLYFcAw1g0z_hFM4u-f5DGs9UiQb-LIjDnbAK0rIZ1oq9z2Jjuc0M8

Infection can cause hypertension

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832987/

https://f1000research.com/articles/6-1953/v1

High oxalates can be formed endogenously, a deficiency in gut bacteria that break them down or from consuming things high in oxalates. If you cook things like kale and spinach in water and then dump the water out most of the oxalates will come out into the water and you will prevent oxalate build up from high oxalate foods.

https://www.kidney-international.org/article/S0085-2538(15)46202-7/fulltext

https://www.mayo.edu/research/departments-divisions/department-internal-medicine/division-nephrology-hypertension/primary-hyperoxaluria

https://journals.lww.com/co-nephrolhypertens/Abstract/2016/07000/Oxalate,_inflammasome,_and_progression_of_kidney.15.aspx

https://www.jpurol.com/article/S1477-5131(16)30268-6/fulltext

Antibiotics and farm chemicals found in our food can cause an imbalance in our gut bacteria which can lead to hypertension.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167910/

https://www.ncbi.nlm.nih.gov/pubmed/29507058

https://www.frontiersin.org/articles/10.3389/fgene.2018.00212/full

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-016-0222-x

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579652/

Certain strains of microbiota can pretect us from heart disease.

https://link.springer.com/article/10.1007%2Fs13167-017-0117-3

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705355/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904929/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596485/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070119/

An imbalance in our gut bacteria can lead to high TMAO levels which can also lead to hypetension.

https://www.selfhacked.com/blog/tmao/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127123/

https://link.springer.com/article/10.1007/s10157-015-1207-y

There are natural and safe ways to inhibit our gut bacterias production of TMAO.

https://www.cell.com/cell/fulltext/S0092-8674(15)01574-3

https://health.clevelandclinic.org/how-gut-bacteria-may-help-curb-heart-disease/

Resveratrol reduce TMAO but cannot be used with those with hepatitis because it activates hepatitis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817264/

I have seen peoples hypertension get worse by taking statins because they deplete CoQ10. CoQ10 deficiency can interfere with sulfation which can lead to hypertension.

https://www.sciencedirect.com/science/article/pii/S0925443918303375?via%3Dihub

https://www.ncbi.nlm.nih.gov/pubmed/27856618

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293250/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247776/

Supplementing with CoQ10 can help with hypertension.

https://www.ncbi.nlm.nih.gov/pubmed/25763201

https://www.nature.com/articles/1002138

High endothelin levels can cause hypertension.

https://www.selfhacked.com/blog/endothelins/?utm_source=ActiveCampaign&utm_medium=email&utm_content=The+Latest+From+SelfHacked&utm_campaign=Jan282018+Newsletter

Inhibited bile production can cause high oxLDL levels. Nrf2 is involved in regulating bile. Nrf2 can be a double edged sword. Under some circumstances over activation can contribute to atherosclerosis.

https://www.sciencedirect.com/science/article/pii/S0098299711000501?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947974/

https://www.ncbi.nlm.nih.gov/pubmed/21484785

https://www.karger.com/Article/Abstract/282091

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413465/

https://www.science20.com/news_articles/nrf2_antioxidant_protein_also_promotes_clogging_arteries-75189

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649703/

https://www.karger.com/Article/Abstract/282091

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128138/?fbclid=IwAR06yjPuia_esapqdIcRz-fJHiEwdntQ6ps6MnaqZDiG4y_KsxyUfaGTRMM

They have found many heart attacks have been caused by taurine deficiency. Taurine deficiency can cause hypertension.

https://www.ncbi.nlm.nih.gov/pubmed/29200904

https://openheart.bmj.com/content/4/1/e000600

https://bodyecology.com/articles/deficient_in_taurine.php

NAC has similar effects as taurine.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721729/?fbclid=IwAR3W9JI1OJEGgpYTpOPp9Q504oCLHelsFBhOYm2YWpIIwfkE83abq_b6yJE

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877599/?fbclid=IwAR0cUiGELVfS1pZcnUGiVTSsoxfV71kYLbtvfmw85rfjjmNhMcnLBy4ZWNM

Vitamin D deficiency has been linked to hypertension. Inhibited vitamin D receptor can cause the body to convert vitamin D and store it in the liver. There are many things that can inhibit the vitamin D receptor like vaccine adjuvants, glyphosate, heavy metals especially mercury and lead. This is why heart attacks occur more frquently in the winter.

https://www.vitamindcouncil.org/health-conditions/hypertension/

https://www.ncbi.nlm.nih.gov/pubmed/29042901

https://www.sciencedirect.com/science/article/abs/pii/S0196978105000380

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662093/

Potassium deficiency can cause hypertension. Also too much salt or too much potassium can through our sodium and potassium ratios out of balance.

http://www.heart.org/en/health-topics/high-blood-pressure/changes-you-can-make-to-manage-high-blood-pressure/how-potassium-can-help-control-high-blood-pressure

https://www.acsh.org/news/2017/04/17/potassium-possible-key-high-blood-pressure-11109

Foods high in potassium.

https://www.myfooddata.com/articles/food-sources-of-potassium.php

Magnesium deficiency can cause heart disease and hypertension.

https://openheart.bmj.com/content/5/1/e000668

https://www.ahajournals.org/doi/abs/10.1161/circulationaha.111.082511

Thiamine can help prevent heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754670/

There are many nutrient deficiencies that can lead to heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963918/

Vitamin K2 is often overlooked.

http://lmreview.com/vitamin-k2-optimal-levels-essential-for-the-prevention-of-age-associated-chronic-disease/

Some vitamins taken in high amounts can cause health problems.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614607/?fbclid=IwAR2AzHRss0mY97hNL1xcN8FF6NNwF_b4BB5NBaTFyXvoiIDzkjWE-c6Yhzs

Sugar added to food may cause hypertension from salt.

https://openheart.bmj.com/content/1/1/e000167

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490579/

https://www.atherosclerosis-journal.com/article/S0021-9150(16)30293-3/pdf?fbclid=IwAR2TU2FjB___3aiaPGzgWVp2waK96kvMYds4GhNoU3W-RRWkYKEAXpd4Uig

Though sodium bicarbonate has been shown to help with many medical conditions if consumed too much it can cause hypertension.

https://www.ncbi.nlm.nih.gov/pubmed/1115072?fbclid=IwAR2pEw3QUjoD7j5rGE_sD6oaktJuFCCYp53HRj_1TzrhIuDdpwHZ8eAdYDY

https://www.adwdiabetes.com/articles/repeated-sugar-spikes-damage-arteries?fbclid=IwAR3rouM9tOEvuwcW57mtNMlJl5qIBrznKeLtj-OYNf95PC7FO0Z-X8v4h-4

Sodium bicarbonate mineral water in moderation reduce cholesterol.

https://www.sciencedirect.com/science/article/pii/S0955286309001703?via%3Dihub

https://www.jems.com/articles/print/volume-35/issue-12/patient-care/sodium-bicarbonate.html

Sodium Bicarbonate does help those who have just had a heart attack.

https://www.ncbi.nlm.nih.gov/pubmed/16490643

B12 deficiency can cause hypertension and mental illness.

https://www.ncbi.nlm.nih.gov/pubmed/22027500?fbclid=IwAR3RjhwX_N3Y-dK0A_g5eKlI4p6UbQGle4gDqMpliebUi1YXgJkv0B4clCk

http://journals.sagepub.com/doi/abs/10.1177/0960327111422404?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3Dpubmed

https://academic.oup.com/qjmed/article/102/1/17/1502492

https://draxe.com/natural-ways-to-lower-blood-pressure/?fbclid=IwAR2UiKVbmI-JaewBRzKLQsWja95xQWM4TLYjJHqERkwDWFlKzOCIF-ERbFg

Riboflavon can help with high blood pressure.

https://jeffreydachmd.com/2015/11/riboflavin-hypertension-mthfr/?fbclid=IwAR0jv-QVVh-xvHOpdxp0dvvZiQkOa8I8JFx3lN4jzKsHKMxrHQ95nSa_xDI

Now we know inflammation can result in hypertension and an imbalance in our electrolytes can cause inflammation.

https://www.nature.com/articles/cddis2015277?fbclid=IwAR0XkTbJiFiOHqFXDFwCADWvprN5olsMBR-Kd2zO268d-Pxm2PkdysDqzOM

Cortisol can disrupt the balance of our electrolytes. High levels can lead to hypertension. This can be caused by many health issues or stress.

https://jasn.asnjournals.org/content/16/12/3507.full?fbclid=IwAR3uabemRgpVLdDGw1nvuEYVrwh2lIn2nflMN6kULgQ87R7tkuNj8Ni28Lo

https://intensivedietarymanagement.com/closer-look-cortisol-hormonal-obesity-xxxx/?fbclid=IwAR0hhNyC3VuONTk5_RmNkWWWHi_983HCVGeZoUIt8s2rNnKYGFn-7colxNI

https://draxe.com/cortisol-levels/?fbclid=IwAR2sUY1no7JscBcZXDBJXvBR1HUn29zvSppX2C9X1Md8xKOZPp19qTGQIeg

https://bebrainfit.com/adaptogenic-herbs/?fbclid=IwAR3xTnmeJ_1EmPUbqYNUBvf6GY3NYoMWaAkJRCoQwVm8lAPi3C95MvV3ZDs

https://www.hormone.org/diseases-and-conditions/pituitary/cushings-disease

https://www.ncbi.nlm.nih.gov/pubmed/6837606/

Information on balancing cortisol.

https://www.lifeextension.com/magazine/2011/9/Reducing-the-Risks-of-High-Cortisol/Page-01

So this indicates that issues with the HPA could cause hypertension.

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302014000100084&fbclid=IwAR0l55NhD0j3rxr4YSmJvL4d7oMntpxSCk7VCGM1wS4aHXeOJhwUfJeZFv4

We cannot exclude pharmaceuticals many of them can induce hypertension.

https://www.uspharmacist.com/article/drug-induced-hypertension?fbclid=IwAR2t8G2kAZ3Nr7gset7zvVU27UQhxWBfO8D3pIojLPq2xSnKMeVewxKmlF4

Insulin resistance can cause hypertension. This can be corrected.

http://whitakerwellness.com/health-concerns/high-blood-pressure-treatment/what-is-insulin-resistance/?fbclid=IwAR2Vyh57CsJctqEUdj_ApI_nWTLASJ7_6Njl13DSeFUF38Ip4Ey-OveMwyw

Cytochrome P450 enzymes involved with cholesterol.

http://dmd.aspetjournals.org/content/34/4/513.long

Low carbohydrate diet can help restore insulin sensitivity. Diets like this should only be used short term.

https://www.ncbi.nlm.nih.gov/pubmed/15767618?fbclid=IwAR3oMme917_SyHxT-bO_jZHIYPXDLRE0geg6iNZA_SHSli1ztmYCr-ICYzY

Astragalus may help restore insulin sensitivity.

https://www.ncbi.nlm.nih.gov/pubmed/19800959?fbclid=IwAR3en_eaO1D8LKqlFrp20gxouvtmCBfcwhZcOHE6ssPzoIBTQdricF-djZY

Burdock can help restore insulin levels to normal.

http://www.scielo.br/scielo.php?pid=S1984-82502016000300425&script=sci_arttext

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355822/

Corn silk helps reduce insulin levels and help prevent cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785813/?fbclid=IwAR0mJhMst0phGZuLX0RvYCAMXYxYjQTIKj-ocJ9WblklmcOC6-_F9MCOn-A

https://www.sciencedirect.com/science/article/pii/S2214750015000487

Our gut bacteria also help regulate our glucose levels.

https://www.cell.com/cell/fulltext/S0092-8674(15)01481-6

Before jumping into supplements it is a good idea to research how they effect the body what is good for one can be harmful for another.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879453/

https://www.ncbi.nlm.nih.gov/books/NBK92767/

Stress can cause heart disease. Though we cannot avoid it we can learn to deal with it in a way that will not cause health issues. Also mindful meditation , prayer and participation in religious meeting have been shown to reduce stress. Also listening to music and socializing has been shown to reduce stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144755/

Gallstones can be caused by many health issues especially issues with high estrogen level, inhibited vitamin D receptor and many other things. If not corrected it can lead to cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678091/

High TH17 levels can cause hypertension. This can be caused by gut microbiome imbalance, vaccine injury, glyphosate and other farm chemicals. It can also be caused by toxins especially heavy metals.

https://www.ncbi.nlm.nih.gov/pubmed/25429518?fbclid=IwAR1Vr3HItxKkRhZ28Z3HXPCNfnWh3lSmvxn0O51T3aEVOxikMcrDql1sjkU

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819301/?fbclid=IwAR34ILCYAIQLDIqzUUIkTnKJq4XCfrS7apLOf-BTnKCrnjCnkDtJa02TlCs

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137509/

Metabolic issues can cause hypertension.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570714/?fbclid=IwAR1y3GXJl8hcq3QaT03WEQYV58v0pQ2geewbDATzilQz4HgmHL3aKtqaQAo#!po=10.0000

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570714/?fbclid=IwAR1hyvZ3xwlTZO9bULgvrotUTWNjzTFBtnyZi0bZr9g4F22zihQKiqSvDaY#!po=10.0000

http://faculty.uml.edu/Jeffrey_Moore/Biophysics_Discussion_Group_Files/Gage%20151208/TSP1%20&%20angiotensin%20II%20inhibit%20sGC%20through%20an%20increase%20in%20intracellulalr%20[Ca].pdf?fbclid=IwAR06T5926h30XXw_YpKT_GsuqIq3M1cjLlCAiZ4OKviufRc73_jx7FrJM40

https://suzycohen.com/articles/methylation-problems/

Plants that may help with metabolic syndrome.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755736/

BH4 issues can cause hypertension. I have posted on BH4.

http://www.j-circ.or.jp/english/sessions/reports/71st/sym10.htm

https://www.fasebj.org/doi/abs/10.1096/fasebj.30.1_supplement.737.6

Folate is needed for BH4 production.

https://www.ncbi.nlm.nih.gov/pubmed/9462523

Toxins like glyphosate, antbiotics especially fluorquinolones and mercury can negatively impact the sulfur status in the body. It is important in the regulation of our blood pressure.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725894/

https://detoxproject.org/glyphosate/glyphosate-and-roundup-negatively-affect-gut-bacteria/

Sulfur deficiency can lead to many health problems.

https://www.westonaprice.org/health-topics/abcs-of-nutrition/sulfur-deficiency/

H2S help regulate blood pressure. In low amounts it reduce blood pressure and when levels are high it can lead to high blood pressure. Gut dysbiosis and over production endogenously can cause excess H2S which can lead to hypertension.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709694/

https://www.ncbi.nlm.nih.gov/pubmed/22535897

It is not mentioned in this study but the sulfur digesting bacteria will break down inulin if you have gut dysbiosis. Inulin usually has good effects on our health but with gut dysbiosis consuming inulin can increase H2S levels causing them to get too high.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852748/?fbclid=IwAR3XgVEz8OH8c8xAc77TSvE74NODyGLbXrKEJb0K-tmY5y8zJeArkZ-q6Ps

Issues with our antioxidant system can cause hypertension. This can be caused by infection, toxins, even stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828811/?fbclid=IwAR1GwT67aN7IdWVk2vCbzl1MPFyPOhEGVTuhbLwlZnB2HbR0GtXnirR1vVY

I usually do not promote allopathic medicines because they usually do more harm then good but studies on Ebselen shows it can help restore the antioxidant system and has many other help benefits.

https://www.nature.com/articles/hr200533?error=cookies_not_supported&code=fcff5dc1-cce0-41e8-8d90-e3b47b23585d&fbclid=IwAR3w2-WsPFZRkBYlYg3AkFAj9X1hUG66VaiBIZx3eLziqW30xJG00mrtylA

Intersting article on homones and the pituitary.

https://www.organiclifestylemagazine.com/healing-the-pituitary-gland-with-nutrition-and-natural-remedies?fbclid=IwAR3bl3dwVG86k-y7IHJFsdQKMXOvYKqPDsGo3S3jkIkm3BlaMYDWojbrgio

https://www.selfhacked.com/blog/need-know-aldosterone-health-effects/?fbclid=IwAR0iSKExm6_alPxk-SgruodjLf5xkGol2dsAb3pCVYHU7Iky9Ehxzs4xzSE

Atherosclerosis causes hypertension, most know inflammation and oxidative stress cause it along with infection. But processed sugar also causes atherosclerosis.

https://www.ncbi.nlm.nih.gov/pubmed/27297845

https://www.lifeextension.com/Magazine/2011/5/Natural-Ways-to-Thwart-a-Stealth-Killer/Page-01

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996922/

G6PD overexpression can cause excess oxidative stress.

http://diabetes.diabetesjournals.org/content/55/11/2939

https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0049128&fbclid=IwAR0fETT-NELDJkCDSxDFX6DsebkQRhC4AVjYw9YWwRxivR0jCLi_O0WIzKQ

Information on oxidative stress.

https://www.futuremedicine.com/doi/full/10.2217/epi-2016-0002

Reducing oxidative stress can reduce blood pressure.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543092/

Copper deficiency can cause cardiovascular disease.

https://wholehealthsource.blogspot.com/2010/04/copper-and-cardiovascular-disease.html

Copper Toxicity can cause hypertension

https://www.holistic-back-relief.com/copper-toxicity.html

High histamines can cause the blood vessels to leak. The body will seal the leaks with calcium resulting in atherosclerosis. Histamines are a result of mast cell degranulation or over consumption of foods that contain histamines or a loss of the histamine reducing bacteria in the gut. There are metabolic issues that cause high histamines.

https://bodyecology.com/articles/do-you-have-histamine-intolerance-4-steps-to-rebuild-tolerance

https://www.ncbi.nlm.nih.gov/m/pubmed/21741097/?i=3&from=/22390690/related

https://www.ncbi.nlm.nih.gov/pubmed/28420489

https://www.atherosclerosis-journal.com/article/S0021-9150(17)31415-6/fulltext

Detailed description of cholesterol.

https://www.docmuscles.com/the-ketogenic-cholesterol-quandry/

https://www.care2.com/greenliving/the-myth-about-ldl-cholesterol-debunked.html

High cholesterol protects from infection and atherosclerosis. But if the body cannot get rid of an infection especially one like Lyme disease it can cause atherosclerosis.

https://academic.oup.com/qjmed/article/96/12/927/1533176

https://www.ncbi.nlm.nih.gov/pubmed/16326170?fbclid=IwAR09U35r544laoZuzHQTMzwUVQouvrEp43oBxXB6jQ4Ms1reHWMwSnDaafA

Things that help prevent atherosclerosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228762/

Fruits and Vegetables and plants that help with atherosclerosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543092/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5228762/

Low dose vitamin C helps with atherosclerosis but high dose cause it. Another problem with vitamin C it can be harmful to those who are G6PD deficient. Megadoses of vitamin C can cause mineral loss in the body and also breaks down red blood cells which can lead to anemia. Also vitamin C increase iron absorption. Megadoses can lead to iron toxicity.

http://altmedangel.com/vitamin-Cdangers.htm

Be pollen helps prevent atherosclerosis. Unfortunately farm chemicals and GMOs have dramatically reduced the bee population and it is getting harder and harder to get.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748819/

This study shows that exercise and purslane seed reduce atherosclerosis but I have seen studies on the plant itself and it has many health benefits and would reduce hypertension.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5137030/

If you crave junk food it is a sign of leptin resistance which can lead to hypertension.

https://wellnessmama.com/5356/leptin-resistance/

Methylene Blue is used to reverse sepsis but should not be used by those with G6PD deficiency or high blood pressure.

https://www.ncbi.nlm.nih.gov/pubmed/788550?fbclid=IwAR1BT2IR3QzoO-1dMR-t9oEv5jo6eOs3Zoj-YY8jFyVXoQ6EUclxmot_5KQ

Ketosis can help with metabolic issues but in some it can cause life threatening ketoacidosis.

https://www.selfhacked.com/blog/ketogenic-diet-keto-diet-ketosis-health-benefits/

https://www.ruled.me/the-ketogenic-diet-and-cholesterol/

Vanillan receptor agonist can help reduce hypertension.

https://www.sciencedirect.com/science/article/abs/pii/S0196978105000380

Mugwort helps with hypertension.

https://www.ncbi.nlm.nih.gov/pubmed/11321437?fbclid=IwAR1ZBVKt-hXwkxMEAAbIANQTHFgC5E5DZc0LuL9lasfj0NERJcKIL9–rfI

https://ecommons.aku.edu/cgi/viewcontent.cgi?referer=https://swisscows.com/&httpsredir=1&article=1032&context=pakistan_fhs_mc_bbs

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512891/

Coconut Oil my help with hypertension.

http://www.nrcresearchpress.com/doi/10.1139/apnm-2014-0351?fbclid=IwAR2Y9PNN44Uj8ikg5jSbhNDw6Jgtlp4a6CNkM6bEHr41I177ila9M9NOtA4&#.W9NtTRqYXMp

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787998/

https://www.sciencedirect.com/science/article/pii/S0009912004001201?via%3Dihub

Stinging nettles helps with hypertension.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009491/?fbclid=IwAR2bfYRfyNzF5DrzFYlXbp3cZC1SR8WtnsSTBKp_FNsRHlOB2PnNxGiii3E

Kudzu helps with hypertension but cannot be used by those with high estrogen levels because it increases estrogen.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784920/

Celery seed helps with hypertension. I know many who reduced their hypertension by juicing celery.

https://www.sciencedirect.com/science/article/pii/S0102695X16301338?fbclid=IwAR1Tf12DWHt7zhISdK1H7f9GQ5pUaq9NH801Z2d-ONJOCcjn0hb-j05JgTg

Nattokinase helps with hypertension it can also prevent thrombosis.

https://www.nature.com/articles/hr2008203?foxtrotcallback=true&fbclid=IwAR1diQKiLh-3Qr8L6IdBd_qihgLSMzy3BmCggnyQ7_Ka9MjVZOhurQKTrqY

https://www.sciencedirect.com/science/article/pii/S0271531709000220?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479826/

Paw Paw can help prevent thrombosis.

https://www.nature.com/articles/srep36462

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654648/

Melatonin is great for healing the whole body so I believe it should help with hypertension.

https://lifespa.com/10-ways-boost-melatonin-naturally/?fbclid=IwAR2KFlpAI5RT0miJpK0e6hhZLegVJjRSDaAq75Xvtbp-aRD50npQjMiBUh4

Bacopa helps with hypertension.

https://www.ncbi.nlm.nih.gov/pubmed/21762768?fbclid=IwAR3lI9M1vYZ3Aq4ehx10sT2-jBlDLxTBzn2TkHHS8-Ym8ONuEYtmY3o_XQU

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319078/?fbclid=IwAR2VsRRSvy-5dTo9J1x3U5M3_wWElWL85T05dWCkJmQlIq81_jhTm87k_dM

Grape seed extract helps with hypertension.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792515/?fbclid=IwAR3wnI6N-bogrA_dx0I4nLZAkK0Xh7H03sLKr2okpWIFv6goeVko5KpEClA

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370781/?fbclid=IwAR3Fm6IcfiFtF3-nnj1_COJ5zDC8jrtR6O67iREIZ3HswDkS73u-yrKGGbg

Hawthorne lowers blood pressure. I have seen many of my friends have amazing results using hawthorne.

https://www.ncbi.nlm.nih.gov/pubmed/16397846?fbclid=IwAR3FTOCdLqmJTWWfLQVsbe7OQoS5J_SF1s9EICCgugJUr-ueEIScVqbgueM

https://www.ncbi.nlm.nih.gov/pubmed/19019730?fbclid=IwAR119aRHNpAMwBl3tfS6nuXVQnNh66CMP-6bytn2-lLJs8BIiO3NCqjSulA

https://www.naturalmedicinejournal.com/journal/2011-07/hibiscus-hawthorn-and-heart?fbclid=IwAR0G-D16-38qmYo-MuArGh34rQJoGhPyYPILkH0j3NgCpylOIpI9ZGctttU

Hesperiden is a helicase inhibitor it helps fight viruses but has also been shown to help with hypertension. It is found in the white parts of citrus peels.

https://www.ncbi.nlm.nih.gov/pubmed/18329851?fbclid=IwAR2Ayq5BliayiU7qIopak-FGsTb9_DuAr5zrYf4i41YqWHUfJYKF7MCSfaE

If you have hypertension marijuana can increase your risk of death.

https://www.escardio.org/The-ESC/Press-Office/Press-releases/marijuana-associated-with-three-fold-risk-of-death-from-hypertension?fbclid=IwAR1jjvRNHdCrMEB7zfO6VfzB1syxG73Dj0I_4F3g4TSMdboGIJfF7MtF9y4#.WiGVVgMxyIo.facebook

Biacalin found in plantain herb, fleabane, and sculetaria helps with hypertension by reducing inflammation and fighting infection. It also reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977663/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189994/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277260/

Bacopa is another herb with great healing properties. It helps prevent thrombosis and cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319078/

Dandelion reduces tryglyceride accumulation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635758/

Rooibos is another tea with great healing abilities. It can prevent thrombosis.

https://link.springer.com/article/10.1007%2Fs12272-014-0501-7

Pyrroloquinolone is amazing at healing, it helped heal the neurological damage I had from Lyme. It has been shown to help with cardiovascular disease and seem like a nutrient that we need. It protects the heart. It is found in green peppers.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140972/

Camu Camu reduces inflammation and oxidative stress.

https://www.sciencedirect.com/science/article/pii/S0914508708001500

Taxifolin helps with hypertension by reducing oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825014/

Nitric Oxide regualtion is important in preventing heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906415/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345541/

Syringaresinol helps increase Nitric Oxide. It can be found in radishes, grape wine, Ginkgo nuts, and Panax gensing berries.

https://openi.nlm.nih.gov/detailedresult.php?img=PMC3317483_emm-44-191-g002&req=4

Beet root can increase nitric oxide.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425174/

Influencing Nitric Oxide is something that has to be done with caution because there is a fine balance in the nitric oxide system that must be maintained.

http://faculty.uml.edu/Jeffrey_Moore/Biophysics_Discussion_Group_Files/Gage%20151208/TSP1%20&%20angiotensin%20II%20inhibit%20sGC%20through%20an%20increase%20in%20intracellulalr%20[Ca].pdf

https://www.pritikin.com/your-health/health-benefits/reverse-heart-disease/331-sex-nitric-oxide-and-your-heart.html

Anti-hypertensive herbs and how they work.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717468/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782109/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202446/

Thyme helps with hypertension.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059611/

Grape seed extract helps with hypertension but those with hepatitis should not take it. It has resveratrol which activates hepatitis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370781/

Self Heal helps with hypertension and helps fight many types of viruses. It works by reducing oxidative stress. It works through the Nrf2 system which has been found to be a target to help in reducing hypertension. It also reduces inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269750/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649703/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133916/

Antiphospholipid syndrome syndrome is an autoimmune disease that can be caused by infection, vaccine injury, toxins especially heavy metals and the farm chemicals in our food. Instead of throwing drugs at it I believe a person should correct the autoimmunity. I have posted on autoimmunity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389011/

https://www.hindawi.com/journals/jir/2014/621270/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389016/

https://healthimpactnews.com/2013/tetanus-vaccine-causes-a-new-disease-known-as-antiphospholipid-syndrome/?fbclid=IwAR2hJkwVFvm0MDpqmh8qC6i6WU8Q6g2zaJXr5Pwpu4N-7Mgoe-2wEM-E2RA

Our food has been fortified with iron and other nutrients to compensate for over farming causing the depletion of minerals and because glyphosate chelates minerals causing food to contain less nutrients. In doing so many have been found to have excess iron in their blood streams. Another thing that can cause iron overload is infection. Some are told to take iron supplements when they already have high levels of iron in their bodies but it is in a form Fe3 that the body cannot use. They will appear to be anemic but when given iron they are adding to the problem. Also many health issues can cause iron overload. Iron overload can lead to hypertension.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763253/

https://www.bmj.com/content/337/bmj.a547

https://www.healthline.com/nutrition/why-too-much-iron-is-harmful#section3

Nutrients that reduce hypertension.

https://www.newswithviews.com/Howenstine/james6.htm

There are many natural ACE inhibitors which will help with hypertension until you can address the cause.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896793/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409655/

Pomegranate is an ACD inhibitor.

https://www.atherosclerosis-journal.com/article/S0021-9150(01)00412-9/fulltext

Marine sources of ACE inhibitors.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866476/

Whole cooked rice is an ACE inhibitor.

http://www.producao.usp.br/handle/BDPI/19480

https://www.sciencedirect.com/science/article/pii/S0023643816305333

Plant sources of ACE inhibitors.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409655/

Pea the legume is an ACE inhibitor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163438/

Some may be experiencing proteinuria which is a symptom of BH4 issues or CBS issues. Increasing heparin helps with proteinuria. Heparin resistance can be cause by an Antithrombin deficiency, injury, or high estrogen levels.

https://cjasn.asnjournals.org/content/2/1/58.full#sec-16

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998275/

Feverfew can reduce hypertension but I do not recommend it because it is addictive and cause toxic withdrawal syndrome which cause super bad headaches. It is very good at fighting colds and the flu but I would not use it for more then three days or so.

https://www.organicfacts.net/feverfew.html

Lactoferrin helps reduce hypertension in a variety of ways.

https://pubs.rsc.org/en/Content/ArticleLanding/2015/FO/C5FO00580A#!divAbstract

Gouda cheese helps with hypertension.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976624/

Wild violet helps with hypertension in a variety of ways.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286389/

Omega 3s can help with hypertension but what I found is if over used you may throw your omega 3 and omega 6 levels out of balance and contribute to hypertension. Also if you have porphyria you will have issues taking any type of oil and it needs addressed. I have posted on porphyria.

https://www.jenreviews.com/omega-3/

https://www.omicsonline.org/open-access/omega-omega-and-omega-fatty-acids-implications-for-cardiovascular-and-other-diseases-2153-0637.1000123.php?aid=35367

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067287/

Medium chain tryglicerides help with many types of illnesses.

https://nutritionreview.org/2013/04/medium-chain-triglycerides-mcts/?fbclid=IwAR3pIfmK0bQ20UmIrzVTgPoglVCur-KDGfliwpUN41o41UIFiZc24uODc9E

Low cholesterol can increase mortality.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247776/

https://bmjopen.bmj.com/content/6/6/e010401.full

https://www.karger.com/Article/Fulltext/355164

http://www.thincs.org/index.php

Cholesterol prevents autoimmunity.

https://www.nature.com/articles/s41598-017-15546-8

Low cholesterol damages the brain. To learn more about statins and their negative effects on the brain read my post about it.

https://www.ncbi.nlm.nih.gov/pubmed/?term=PMC5806328

Not only that but statins may contribute to heart disease.

https://www.tandfonline.com/doi/abs/10.1586/17512433.2015.1011125?journalCode=ierj20

As cholesterol levels go up heart disease goes down.

https://drmalcolmkendrick.org/2015/12/21/cholesterol-goes-up-heart-disease-goes-down/

https://academic.oup.com/ajcn/article/101/4/705/4564505

https://www.mdpi.com/2072-6643/7/9/5344/htm

https://www.ihealthtube.com/video/will-forever-change-how-you-view-cholesterol-and-heart-health

cholesterol is an anti-inflammatory.

https://www.sciencedaily.com/releases/2013/12/131209105240.htm

Benefits of cholesterol.

https://www.thehealthyhomeeconomist.com/the-9-benefits-of-cholesterol-in-the-diet/

https://chriskresser.com/why-you-should-eat-more-not-less-cholesterol/

http://www.13.waisays.com/cholesterol.htm

There are a lot of myths about fats that are stated by medical professionals as fact and they are not scientifically true. One is fat and cholesterol cause hypertension. They have been promoting the wrong fats as healthy and have been falsely claiming cholesterol causes heart disease. That is why obesity and heart disease rates have climbed dramatically in the United States. One myth is that fats cause hardening of the arteries and that is not true.

https://www.ncbi.nlm.nih.gov/m/pubmed/30101436/?fbclid=IwAR3XgDkZdn_jW1v3KzP4XcElqmhei6ib8a2xs8yeVlfeF05Vnyl6JSaWnlM

http://www.diabetes-book.com/truth-fats-iv/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824150/

Low triglyceride levels increase mortality from stroke and increased risk for heart disease.

https://www.karger.com/Article/Pdf/70119

https://healthvigil.com/low-triglycerides-causes-symptoms-dangers-treatment/

Fat consumption does not correlate with lipid levels in blood vessels.

https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.27.2.229

MUFA is good fat.

https://www.ncbi.nlm.nih.gov/pubmed/10584045

Saturated fat is good fat.

https://www.healthline.com/nutrition/grass-fed-butter-superfood-for-the-heart

Cod liver oil in moderation can help with cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pubmed/12415563?fbclid=IwAR0Ia5-ooJYk39tCns1W3fJfexvllYlfkfvMBIbhg7MO4qMz-UJUuWBB1ns

https://www.ncbi.nlm.nih.gov/pubmed/2718528?fbclid=IwAR1xwH4MhI7qF6Yv4dWbtGdU_33Z_cEILj14LMvWpA1KfWQSMDbIrz_abqY

https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0061109&fbclid=IwAR0mqoIfB2oA1pWRaLgDvPQyizc0aAVWg4bTyUt1fsld8XPHFdkH1UDz_xU

HDL is considered good cholesterol but it can cause atherosclerosis if lipid peroxidation occurs.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656652/

Under the correct conditions HDL prevents inflammation.

https://www.sciencedaily.com/releases/2013/12/131209105240.htm

Black seed heals many things it has amazing healing abilities.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112739/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387229/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387232/

Trans fatty acids which were promotes as the new fat that was going to prevent obesity and heart disease has been found to cause them.

https://www.nature.com/articles/1602973

Lycopene found in the skins of tomatoes has been shown to have many health benefits especially on the heart.

https://www.spandidos-publications.com/mmr/11/1/374

Astaxantin has been shown to provide the brain with energy, it also reduce oxLDL by reduding oxidative stress.

https://link.springer.com/article/10.1007%2Fs11130-011-0258-9

Mediterranean diet can reduce hypertension.

https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0089082/#summary.s9

This study discusses balancing pretty much everything.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682319/

Cissus helps prevent high blood pressure.

https://www.organicfacts.net/health-benefits/other/cissus-quadrangularis.html

Ajuna helps with hypertension but has many side effects.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220499/

Berberine found in barberry helps with diabetes, and heart disease. It reduces tryglyceride levels. It also reduces oxidative stress. Berberine also increases the good gut bacteria that protect the heart and prevent obesity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843280/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840547/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341350/

https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(17)31404-1

Histidine prevents heart injury.

https://www.sciencedirect.com/science/article/pii/S0928425799801533?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418549/?fbclid=IwAR2OJYonX8xDa3aADR9ReBLVMAn_hb4PBSj-viXyc3M2CP2YCt785qUZmsc#!po=31.5000

This is one example of how processed food can cause health problems. I posted on how toxic our food is. There are many foods that will cause health problems that are actually considered healthy.

https://www.healthy-holistic-living.com/instant-noodles-inflammation-dementia.html

https://wholehealthsource.blogspot.com/2008/06/masai-and-atherosclerosis.html?m=1&fbclid=IwAR0jxeqfs-Q7d0UifvFWi9E3ObaTxDShSfxxED5YpfO1kiMSXOC5fzIi22E

Gingko and Sophora may help with cardiovascular disease because it helps decrease the vasoconsriction response cause by excess histamines and bradykinnins.

https://www.worldscientific.com/doi/abs/10.1142/S0192415X16500907?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

https://www.ncbi.nlm.nih.gov/pubmed/20717872?fbclid=IwAR34yr0a5q4R_tM2249YeHI8YsrTxOamvfeZ4AEuy3ycw70YEoXr_Q6A9uw

Correct breathing methods are needed for healthy blood pressure.

https://www.normalbreathing.com/learn-8-diaphragmatic-breathing.php

Herbs that can be used during pregnancy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677329/

Aged garlic extract can help with heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753981/

Okra has been found to help heal many things including cardiovascular disease. It also helps with diabetes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178946/

Resistant starch a type of fiber helps reduce blood pressure most fiber does.

https://www.thehealthyhomeeconomist.com/best-resistant-starch-for-gut-health/

https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(03)00299-7/fulltext

Resistant starch helps our gut bacteria produce butyrate which helps prevent heart disease. It can also be found in butter.

https://wholehealthsource.blogspot.com/2009/12/butyric-acid-ancient-controller-of.html?spref=fb

Citrus extracts and their beneficial effects on heart disease.

https://academic.oup.com/advances/article/5/4/404/4568623

This is a type of Golden Rod. Most species are chemically similar. They can inhibit the absorption of cholesterol so if you have low cholesterol levels you may want to avoid golden rod.

https://www.ncbi.nlm.nih.gov/pubmed/25898223

Blue Berry honeysuckle helps prevent heart disease.

http://biomed.papers.upol.cz/artkey/bio-200702-0001_BERRY_FRUITS_AS_A_SOURCE_OF_BIOLOGICALLY_ACTIVE_COMPOUNDS_THE_CASE_OF_LONICERA_CAERULEA.php

White malberry can help with hypertension

https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201600233

Many spices have anti-inflammatory effects. This study talks about cancer but it mentions various spices and their anti-inflammatory abilities. Inflammation can lead to atherosclerosis.

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-018-1381-2

Saffron has a lot of health benefits and reduces cardiovascular disease.

https://www.sciencedirect.com/science/article/pii/S0019483216301924?via%3Dihub

These plants have steroid like effects. I would not use them long term but they have less side effects then man made steroids.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873812/

Thiocyanate helps prevent atherosclerosis. Excess Thiocyanate can cause thyroid problems it inhibits iodide transport when levels get too high.

https://www.ncbi.nlm.nih.gov/pubmed/19918082

https://www.ncbi.nlm.nih.gov/pubmed/14757960

https://www.omicsonline.org/open-access/iodine-thiocyanate-and-the-thyroid-2167-0501-1000171.php?aid=54337

Evening primrose oil helps with cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961099/?fbclid=IwAR0Zjp-9UpbOW7vjRWJv7IyL6iG6Xx0LyRg4YRFlAorBuGzeMqAV1cYZfdU

https://www.ncbi.nlm.nih.gov/pubmed/26781763?fbclid=IwAR2L5eppvmVRvUFP0kKbQmpR2w4WbRZ4rlp9EzjePO0mw7TFiquOXyaEzMo

Beta Glucan in oatmeal reduces cardiovascular disease. Mushrooms also contain beta glucan. Make sure you get organic oatmeal because non organic is high in glyphosate which causes heart disease.

https://www.ncbi.nlm.nih.gov/pubmed/21631511?fbclid=IwAR3zQlXw-3mzlqZiCCzJF8qRAeSXvYu41UEyatzTlZoi2jkBs7la9d-BysE

Japanese honeysuckle helps with heart disease and reduces hydrogen peroxide levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823622/?fbclid=IwAR2yvwYsoifgJ5HtePoOzJSkzz4OrcAZEhSKOKk6v-ssZiX5VWgme_m1boA

Tumeric has been shown to reduce atherosclerosis but you have to use it in moderation it contains curcumine which chelates iron and long term use can make you anemic.

https://www.naturalnews.com/042961_turmeric_laurel_leaf_extract_atherosclerosis.html?fbclid=IwAR3zHlKdootGM2FOblUkNW6idKjwxSwprb0TkVSUn9-mXJglFIyJJrHQLlo

Getting measles when young reduces your risk of atherosclerosis when you get older.

https://www.ncbi.nlm.nih.gov/pubmed/26122188/?fbclid=IwAR14eDAp3pGnrOGdhiv9tbb2imdM1OfON9S71MdfKYN98ypbEoCHJ3LGOiw

Getting sunlight helps prevent atherosclerosis.

https://www.ahajournals.org/doi/abs/10.1161/ATVBAHA.116.308063?fbclid=IwAR2wU73j36fDdIED5m5Cb_dmbvBSCPSiY9_ol8A1NuZOTe4pb9Q6HeKELxo

Skipping breakfast increases the risk of atherosclerosis.

http://www.onlinejacc.org/

Reversing atherosclerosis.

https://www.drberg.com/blog/reversing-atherosclerosis-or-hardening-of-the-arteries

https://holisticzine.com/reversing-atherosclerosis

A polypore mushroom that grows in South America may be able to reverse atherosclerosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523071/

Astaxanthin may be able to reverse atherosclerosis.

https://www.hindawi.com/journals/bmri/2017/4625932/

Krill oil may reverse atherosclerosis by activating PPAR.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864551/

Oxidative Stress, the antioxidant systems and how they effect our health.

This is not medical advice, I am posting this for educational and informational purposes.

People have come to view oxidative stress as a villain but it is needed to remain healthy. It is when oxidative stress reaches levels that cause an imbalance is when it becomes a problem. The key to healing is balancing the antioxidant and oxidative stress systems.

This is a basic description of oxidative stress.

https://www.drweil.com/vitamins-supplements-herbs/supplements-remedies/stumped-by-oxidative-stress/

This is a fairly accurate description of oxidative stress but they mentions folic acid which is man made and toxic and can build up in the body causing many health problems including cancer. If you take supplements make sure they contain folate not folic acid.

https://doctordoni.com/2017/12/what-causes-oxidative-stress/

If you want a more in depth explanation this is a good link to follow.

https://healthjade.com/oxidative-stress/

Excess Oxidative stress leads to chronic illness there is a test to see if you have excess oxidative stress. If you do not get it resolved you cannot heal. You can get a test to check oxidative stress levels.

https://www.sciencedirect.com/science/article/pii/S0009898103004534

This a small list of illnesses caused by oxidative stress.

http://www.oxidativestressresource.org/

https://www.verywellhealth.com/oxidative-stress-and-your-health-89492

Nrf2 is the master regulator of the antioxidant system. Over activation of Nrf2 can cause health problems and if it is inhibited we can experience excess oxidative stress which leads to chronic illness.

Nuclear Factor-Erythroid 2 Related Factor2 (Nrf2) is a major mechanism in the antioxidant system to protect our cells from oxidative and electrophilic stress. The Nrf2 signaling pathway controls the genes that are responsible for the detoxing byproducts of reactive oxygen species (ROS) and and electrophilic reactions. Nrf2 is controlled in part by Keap1 protein. If this pathway becomes blocked many things can happen . It can set of a chain of events because when ROS and the byproducts build up in the body they can severely damage it. The types of damage can be anything from cancer, liver damage, DNA damage and many other things. So the Nrf2 has to be carefully modulated , we do not want it to go to much one way or the other. ROS protects our bodies from toxins and pathogens. So it needs to be tightly regulated because an over abundance can cause severe damage in our bodies and even cause our bodies to start attacking themselves. If the Nrf2 pathway becomes blocked ROS will build up in the body and we lose the ability to detox ROS efficiently. Many neurological issues can be linked to excess oxidative stress.

Nrf2 protects us from oxidative stress by reducing ROS. When byproducts of ROS like hydrogen peroxide are present they signal the induction of the Nrf2 pathway and certain genes are express to deal appropriately with the oxidative stress. If it becomes blocked then the Nrf2 cannot respond to reduce the oxidative stress. There are many things that can cause the Nrf2 to lose it’s ability to reduce oxidative stress. Excess toxins like lead, mercury, fluoroquinolones, fluoride, endotoxins from pathogens, toxins from genetically modified foods , herbicides and pesticides. I could do a whole page on things that can interfere with the proper function of the Nrf2 antioxidant system.

So you can see the importance of Nrf2 in the homeostasis of the redox system and mitochondrial homeostasis. A brief note Nrf2 is also important in reducing inflammation throughout the body.

Glutathione and Nitric Oxide are very important for cell survival of various types. Excess ROS can deplete glutathione and nitric oxide. This can farther inhibit the ability of Nrf2 to respond. This can result in destruction of various tissues throughout the body. It can result in blood clotting, and a break down of the veins throughout the body. So you can see the importance of keeping the Nrf2/Keap1 pathway functioning properly. Without the function of the Nrf2 our bodies cannot protect themselves from many things this can result in cancer and even autoimmune disease. Over activation of Nrf2 can reverse damage from many types of injuries caused by our environment. But over activation has been found to feed some types of cancer, yet over activation can kill other types. That is why we want to achieve homeostasis, with all supplements and foods use moderation. Persistent over activation of Nrf2 has been shown to cause certain type of liver cancer.

If you take antioxidants and the Nrf2/Keap1 pathway is blocked you will increase the ROS in your body. With no way for your body to neutralize the by products and recycle the antioxidant you will increase the toxic loads in your body causing even more damage and increasing your chances of getting cancer.

Gankyrin increase when there is an increase of hydrogen peroxide a byproduct of ROS. Gankyrin competes with Keap1 for binding with Nrf2. This prevents the degradation of Nrf2 causing an excess. This can prevent apoptosis of cancer cells. Gankyrin reduces ROS induced cell damage. Remember I said that ROS is used to protect us. It is used by the body to destroy cancer cells, pathogens, toxins and other things. We need to find a balance and try to reach homeostasis because remember excess ROS also causes cancer and tissue destruction. Reducing oxidative stress and inflammation helps restore gankyrin homeostasis.

Some Nrf2 activators are Alpha Lipoic Acid. ALA is produced by the body, excess oxidative stress causes it to become depleted. It is found in every cell of the body and is an antioxidant also. Some antioxidants work in water and some in lipids (fats). ALA works in both water and oil. It can be replenished in the body by eating red meat high in Omega 9 fatty Acids and brewers yeast. Over consumption of ALA can cause a reduction in blood sugar levels resulting in hypoglycemia, it can reduce thyroid hormones and cause thiamine to become depleted.

Sulforapane is found in cruciferous vegetables like broccoli, cabbage and cauliflower. Cooking them raises the level of sulforopane. If you have sulfation issues they should be addressed or consuming sulfur containing foods will make you ill. It can cause an increase in ammonia and sulfites which are toxic to the body and will increase oxidative stress. High ammonia levels will make our digestive system and bladder alkaline instead of acidic. Restoring the PH of our bladder and digestive system back to acidic is very improtant. Alkaline enviroment makes candida go from commensal to pathogenic. It also creates an environment that is friendly to other pathogens so they can take hold. Gut dysbiois and candida can also increase sulfite levels. CBS and BH4 pathways are effected by sulfation issues and can be upregulated under oxidative stress which would cause them to produce high sulfite levels and could cause us to develop Pyrrole issues(problems with fats) and problems eating meat. We can also develop porphyria. So it is very important to restore Nrf2 homeostais. Pyrrole issues will effect our bile production which then effects digestion issues. Our food will sit and ferment in our guts instead of digesting. This causes many toxins. Pyrrole issues also lead to gall bladder pain and can lead to swelling and infection in the gall bladder. Gall bladder problems will cause pain or burning below the right arm pit.

Cinnamic Acid is found in the bark of many species of cinnamon trees. It has been shown to induce apoptosis of cancer cells. Over use can result in raised oxalate levels.

Tumeric is high in curcumin. Over use can deplete the body of iron and raise oxalate levels. Black pepper causes it’s effectiveness to dramatically increase, so use less if taken with black pepper.

Oleanolic Acid can be found in olive oil, clove, wild rose leaves, honey mesquite and many other plants it is an Nrf2 activator. Salvianic Acid is found in schisandra. Salvianolic Acid is derived from chinese sage also known as red sage. These are also Nrf2 activators.

Redox signaling molecules are also involved in oxidative stress homeostasis. They detect and signal when the body is under oxidative stress and are involved in the bodies response. They are key to our cells response. The signal cell repair or recycling , chelating toxins from the body, cellular autophagy and cell death known as apoptosis. Just as most chronic illness can be linked to Nrf2 they can also be link to the redox system.

https://www.honeycolony.com/article/redox-signaling-molecules/

This is a description of redox and how it works. This article also discusses ASEA. I looked around the internet and on social media and have seen many positive comments. I cannot find an ingredients list so I cannot decide what I think, I could not find any research that satisfied my questions I had. Seems this person had the same results. So I remain neutral as to what I believe on ASEA.

https://supplementclarity.com/asea-review/

This is a more detailed description of redox signaling and how it works. This also explains how Nrf2 and redox signaling interact.

https://www.cell.com/current-biology/fulltext/S0960-9822(14)00326-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0960982214003261%3Fshowall%3Dtrue

https://drgarysamuelson.com/2017/10/11/all-in-the-genes-redox-signaling/

 

This is an interesting report on oxidative stress and it’s effects on the heart. As you learn you will come to realize that LDL is a symptom and not a cause and reducing LDL does more harm then good because cholesterol is an antioxidant.

https://www.frontiersin.org/articles/10.3389/fphys.2018.00672/full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083812/

Antioxidants can reduce oxidative stress if the antioxidant system is working but will increase oxidative stress if there are problems. This is why these problems need to be address or else our efforts will be futile.

https://www.karger.com/Article/FullText/485089

 

Toxins and infection can lead to excess NMDA receptor activation which can lead to nitrosative stress.

https://www.researchgate.net/profile/Zezong_Gu2/publication/42441952_Redox_Reactions_Induced_by_Nitrosative_Stress_Mediate_Protein_Misfolding_and_Mitochondrial_Dysfunction_in_Neurodegenerative_Diseases/links/575a2c2e08ae9a9c954f2c86/Redox-Reactions-Induced-by-Nitrosative-Stress-Mediate-Protein-Misfolding-and-Mitochondrial-Dysfunction-in-Neurodegenerative-Diseases.pdf?origin=publication_detail

Redox code is a set of principles that describe redox organization and function.

https://www.researchgate.net/profile/Helmut_Sies/publication/275217997_The_Redox_Code/links/55a7c42208ae847d362de297/The-Redox-Code.pdf?origin=publication_detail

 

Redox molecules are involved in DNA repair mechanisms. ROS is involved in redox signaling and oxidative stress. Immune dysfunction can contribute to oxidative stress.

https://academic.oup.com/nar/article/44/10/4721/2516100

https://www.sciencedirect.com/science/article/pii/S0960982214003261

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250048/

We need oxidative stress but health problems arise when it gets too high.

https://www.selfhacked.com/blog/oxidative-stress-101/

 

Not all stress is bad we need eustress to stay healthy. Also how we deal with things can determine if it is unhealthy oxidative stress or healthy eustress. Also too much eustress can be unhealthy.

https://www.verywellmind.com/what-you-need-to-know-about-eustress-3145109

http://inspireyouthful.com/health-wellness/what-is-eustress-and-how-can-it-improve-your-life/

Intermittent fasting has been an eustressor that has been shown to have health benefits.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608558/

https://pdfs.semanticscholar.org/60bf/f8a704cc0e7369840d4afad8fa7465d8d878.pdf

Little things matter, even our choice in music can effect how our bodies respond.

https://www.sciencedirect.com/science/article/abs/pii/S0167876016307267

Hydrogen Peroxide is a major signaling molecule. There are many things that can cause high levels which can lead to an over production of oxidative stress. This can result in cancer, diabetes, heart disease and many other forms of chronic illness.

https://www.sciencedirect.com/science/article/pii/S2213231716303196?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412967/

I had jobs where the bosses put constant stress on people and would be constantly trying to find reasons to write employees up. They would always be critical of everyone. This caused a high employee turnover. I watched many companies lose money because the wisest and most skilled and efficient workers would leave for jobs that they were more appreciated at. I myself often did that because I noticed it had a negative impact on my health. Most people I worked with welcomed challenges in their jobs but when it became more oppression rather then challenge me and my fellow employees became stressed. When employees are challenges it causes a good type of stress called eustress but when it becomes oppressive the stress effects peoples health negatively.

https://onlinelibrary.wiley.com/doi/abs/10.1111/aphw.12049

Stress has a dramatic negative impact on our health and it is why we need to learn to deal with it in a way that will not effect our health .

https://www.ncbi.nlm.nih.gov/pubmed/23490070

Exercise is a source of eustress unless we over do it.

https://journals.lww.com/nsca-jscr/fulltext/2012/12000/Physical_Exercise_as_an_Epigenetic_Modulator__.38.aspx

 

Selenoprotein is probably one of the most important molecules in the redox system. They prevent excess oxidative stress, regulate thyroid hormones, help to detox the body, protect the body from inflammation, infection and cancer. A deficiency in selenium makes us susceptible to oxidative stress, chronic illness and dramatically increases our risk for cancer. Selenoproteins and Nrf2 are essential for oxidative stress homeostasis.

http://www.bloodjournal.org/content/117/3/986?sso-checked=true

http://www.jbc.org/content/284/2/723.full.pdf

http://bioinformatica.upf.edu/2006/projectes06/3.4/paper6.pdf

https://pdfs.semanticscholar.org/8611/8b8c1a6149e0e22d6184bf59ee2b446563e5.pdf

Now if you have read the information you will see that high Selenium levels can also cause problems and has been linked to Type 2 diabetes. This shows the importance of homeostasis and not over doing things.

https://lpi.oregonstate.edu/mic/minerals/selenium

Selenoproteins and their effects on the brain and illnesses linked to them.

https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.1262

SEP15 is involved in protein folding. It is kept in check by Mehionine Sulfoxide reductase. Msr decreases as we age. This results in protein damage. It can also become depleted during excess oxidative stress. Mrs protects from mitochondrial damage.

https://www.ncbi.nlm.nih.gov/pubmed/28158949

https://www.physiology.org/doi/10.1152/ajpendo.00453.2015

Increasing Msr may increase life span and quality of life.

http://www.pnas.org/content/99/5/2748

A decrease in MsrA can make cancer more aggressive.

http://www.pnas.org/content/107/43/18628

Resveratrol, astaxanthan, biacaein, butyrate, selenium, and vitamin D activates 3a(FOXO3a) which activates Mrsa. Those with hepatitis have to avoid Resveratrol it activates the hepatitis virus.

https://www.sciencedirect.com/science/article/pii/S0955286312002124

https://biofoundations.org/astaxanthin-natural-substances-increase-activity-foxo3-longevity-gene/

 

Hemoproteins are another set of redox proteins that are important for detoxing the body, for oxygen transport and many other functions. Inceasing heme increases Hemoproteins. Excess heme raises the risk of cancer and increases oxidative stress. Heme homeostais is very important. Iron is needed for the production of hemoproteins. Too much iron can cause many health problems.

There are others, like iron-sulfur proteins, cupropoteins, flavoproteins, pteroproteins, molybdproteins, manganoproteins. A deficiency in the nutrients needed to produce these proteins or metabolic issues can prevent them from being produced. This disrupts our redox system causing excess oxidative stress.

NAD and NADP systems along with Thiol/disulfide systems are key to the redox code. If there are problems with these then our redox systems ability to function is effected.

You can usually tell what pathways are effected by the symptoms of the illness. This can help guide us to any nutrient deficiencies or metabolic pathways that may be blocked or inhibited.

Excess oxidative stress can rapidly deplete our nutrient supply and can produce endogenous toxins faster then the body can remove them so it is very important to address any health issues and nutrient deficiencies as soon as possible. If we do not then then our immune system is effected and we develop inflammation and immune issues like an imbalance in our T cells. It starts a cycle that is very hard to break. To break the cycle it takes self discipline, learning to pay attention to our bodies and what it is telling us. Also constantly adjusting our protocols as we heal and our bodies needs change. Once our immune system are out of balance and we develop inflammation many metabolic pathways get blocked inhibiting our bodies ability to produce certain enzymes. The body does have alternative pathways but they produce toxins when used. This creates a bigger problem because the inflammation blocks our ability to detox properly. Addressing inflammation and balancing our immune systems are key to reaching homeostasis so we can heal.

Thiols are important in reduce balance. An imbalance in thiol redox can lead to chronic illness, mental illness, neurological damage and many other health problems.

https://www.sciencedirect.com/science/article/pii/S221323171500035X

 

High ROS and RNS levels can oxidize cysteine which leads to inflammation and asthma.

https://www.ncbi.nlm.nih.gov/pubmed/25565397

Redox reactions involving thiols.

https://chem.libretexts.org/Textbook_Maps/Organic_Chemistry/Book%3A_Organic_Chemistry_with_a_Biological_Emphasis_(Soderberg)/16%3A_Oxidation_and_reduction_reactions/16.12%3A_Redox_reactions_involving_thiols_and_disulfides

Molybdenum can become depleted when under extreme oxidative stress. Symptoms of molybdenum deficiency are night blindness, rapid breathing, sulfur sensitivity. Molybdenum is needed to prevent oxidation of thiol groups.

http://www.healthsupplementsnutritionalguide.com/molybdenum/

https://www.drweil.com/vitamins-supplements-herbs/supplements-remedies/molybdenum/

Manganese iron interaction.

http://m.jbc.org/content/287/17/13541.full

So we can see the importance of balancing systems that are dependent on thiols. If there are CBS issues this will effect thiol redox status and needs to be addressed.

http://www.connersclinic.com/balancing-cbs-defects/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029659/

BH4 issues can also effect thiol redox. So if we have BH4 issues they should be addressed.

https://www.ncbi.nlm.nih.gov/pubmed/28104455

Endotoxins cause BH4 to upregualte to protect the brain. This can result in high sulfite levels in the body which can cause problems.

https://www.sciencedirect.com/science/article/pii/S0006899318300660?via%3Dihub

This can cause BH4 to become depleted if we do not reduce the toxic load. This can lead to cardiovascular disease.

https://www.liebertpub.com/doi/full/10.1089/ars.2013.5566

These illnesses can cause sulfite sensitivity , in order to reach redox homeostasis we must address high sulfite levels. With the proper nutrients these things can be corrected. When we are sensitive to sulfites we develop allergies, asthma, food intolerances and if severe enough we can develop many types of chronic illness.

https://my.clevelandclinic.org/health/articles/11323-sulfite-sensitivity

http://www.beatcfsandfms.org/html/Sulfides.html

https://www.imoa.info/HSE/environmental_data/biology/reviews-of-molybdoenzymes/16-sulfite-oxidase.php

These issues can also be caused by farm chemicals in our food disrupting our gut bacteria. Bile production can be severely impacted. When the bile production is effected, it reduces the production of digestive enzymes in the pancreas which will make food sit and ferment in our stomaches. This makes it feels like we have a brick sitting in our stomach.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/

Antibiotics cause dramatic changes to the redox system which can lead to chronic illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008055/

There are many things that can cause haptens. Tick born illness, drugs, toxins especially farm chemicals. Heavy metals can also cause them. If we develop high hapten levels our skin may blister or get rashes similar to a poison ivy rash. If we do not address them it can cause issues with many metabolic pathways.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447324/

https://www.hindawi.com/journals/bmri/2014/640754/

Some foods are high in sulfites. They are additives in food and can inhibit our beneficial gut bacterias growth.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186629

Hydrogen Sulfide is a redox signaling molecule that can reduce oxidative stress but in excess it inhibits ROS which is also a redox signaling molecule needed by the body. Gut dysbiosis can cause high hydrogen sulfide levels which creates a new set of problems. This can lead to damage to the digestive system. Our guts will become higher in sulfur digesting bacteria. This prevents our food from digesting properly and it will ferment instead. This leads to high levels of Hydrogen sulfide. Hydrogen sulfide can cause hibernation like symptoms and lead to chronic illness. The body only needs a very small amount. If levels get too high we can develop ulcerative colitis, IBD or any other inflammatory gut disease. When our gut bacteria are out of balance and we have too many sulfur digesting bacteria it feels like there is a brick sitting in the gut after we eat. Our guts will bloat out and look like we are pregnant. It is very different then fat because fat is soft when it is bloated out from our food fermenting it will be hard to the touch. When we have a large gut from hormonal issues it will be softer to the touch and usually will saga bit. I have posted information on dealing with these things. If you are dealing with this issue bismuth has been shown to reduce hydrogen sulfide levels. If this occurs we lose our butyrate producing bacteria. Butyrate is needed for gut health , nerve and brain health.

https://www.hindawi.com/journals/omcl/2016/6043038/

https://www.badgut.org/information-centre/a-z-digestive-topics/the-role-of-sulphur-in-uc/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508456/

https://www.nature.com/articles/ajg2014427

High H2S levels will inhibit heme production which is needed for the production of redox molecule hemoprotein. This can lead to excess oxidative stress and anemia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118656/

Ergothionine is a thiol is found in black beans, kidney beans, bolete and oyster mushrooms and oat bran. Ergothionine protects against oxidative stress, cancer, neurological disease, and improves sensitivity to acetylcholine.

https://www.sciencedirect.com/science/article/pii/S0024320518303837?via%3Dihub

https://www.ncbi.nlm.nih.gov/pubmed/29530864

https://www.nature.com/articles/s41598-018-20021-z

https://pubs.acs.org/doi/abs/10.1021/jf071328f

Oxalates have a dramatic effect on the redox system and can be caused to be produced endogenously by toxins like glyphosate, glufosinate, fluorquinolone antibiotics, fluoride, heavy metals. Some foods are high oxalate and should be cooked before eating. Spinach is very high oxalate and I see many people eat it raw. Cooking breaks the oxalates down. Certain metabolic issues can also cause our bodies to produce oxalates. Most metabolic issues can be corrected with the right nutrients.

https://www.karger.com/Article/Abstract/82043

https://www.sciencedirect.com/science/article/pii/S2213231717307565

I don’t mention often N-Acetylcysteine because it is not good for all. Also I noticed that long term use would start having negative effects. So maybe taking it once in a while which is what I did helps but frequent use seems to have the opposite effects. NAC will reduce thiol levels if they are high.

https://www.ncbi.nlm.nih.gov/pubmed/11350834

I have friends who are into electronics and love studies like this so I am putting this here for them. It is the electrochemical properties of some vitamins.

http://jes.ecsdl.org/content/165/2/G18.full

The folate cycle is important in redox homeostasis.

http://synergyhw.blogspot.com/2015/04/nadph-folate-cycle-and-adrenal-function.html

If the cause of oxidative stress is not addressed it can deplete thioredoxin reductase. This can lead to neurological damgae.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050683

G6PD protects our blood cells from oxidative stress. Because they lack mitochondria they do not have a back up system for protection. Glyphosate , fluoroquinolones and other toxins can reduce G6PD. Also excess levels of Vitamin C from taking to much in supplements can deplete G6PD. Oxidative stress can deplete G6PD. G6PD is vital to redox balance. They claim some can inherit a defect that causes this but our group on Facebook Synergistic Illness has found many things they claim to be inherited can be linked to vaccine injury, eating habits passed on from family, inherited gut bacteria or many other environmental factors like how we are taught to handle stress.

https://www.ncbi.nlm.nih.gov/books/NBK22389/

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049128

http://g6pddeficiency.org/wp/#.W2OYRB6YXMo

Many get upset when I do not agree with them taking DHEA. It inhibits G6PD, many things can inhibit G6PD and they could be adding to the problem.

http://www.jbc.org/content/273/17/10609.full

Some may see this study showing high vitamin C levels is good in G6PD deficiency. But the flaw of this study is they did not look at the effects on red blood cells. Studies have shown that high doses of vitamin C break down read blood cells which would defeat the purpose of Vitamin Cs antioxidant effects.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295168/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1677333/

G6PD does help regulate our sugar levels so we do not want levels to get too high. It can also can illness. Homeostasis should always be the goal.

http://diabetes.diabetesjournals.org/content/55/11/2939

Omega 3 fatty acids help with G6PD deficiency.

https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-11-6

http://g6pddeficiency.org/wp/living-with-g6pd-deficiency/g6pd-deficiency-diet-suggestions/#.W2OlgR6YXMo

What could cause high G6PD levels? Endotoxins which shows the importance of detoxing them.

https://www.researchgate.net/figure/FFA-and-LPS-stimulate-G6PD-expression-in-macrophages-A-and-C-Induction-of-G6PD-mRNA-by_fig2_236189144

Catalase reduces ROS. Most plants that contain it also are high in sulfur so those with sulfation issues need to avoid high sulfur foods until they have addressed their high sulfite leves. There are plant sources of catalase that are not high sulfur if you do your research.

https://healthyeating.sfgate.com/vegetarian-sources-catalase-3693.html

Hawthorne leaves and berries have many health benefits they also help reduce lung inflammation.

https://link.springer.com/article/10.1007%2Fs10753-014-9863-8

It also helps regulate the antioxidant response.

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.5035

https://link.springer.com/article/10.1007%2Fs12010-013-0667-3

https://journals.lww.com/cardiovascularpharm/Abstract/2013/08000/Effects_of_Selected_Bioactive_Natural_Products_on.1.aspx

Wild Basil helps reduce oxidative stress and inflammation. Most spices contain similar phytochemicals so this is true for many spices.

https://repository.arizona.edu/bitstream/handle/10150/221271/Burk_David_Thesis.pdf;sequence=5

Galinsoga reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pubmed/26092182

https://www.ncbi.nlm.nih.gov/pubmed/24066513

https://www.ncbi.nlm.nih.gov/pubmed/22085305

 

 

 

 

 

 

Hyper Excitement of NMDA (autism also known as encephalitis)

This is not medical advice I am posting this for informational and educational purposes.

stock-photo-concept-of-human-intelligence-with-human-brain-on-blue-background-294471983

The NMDA receptors in the brain is one of the most effected when we are ill. It can cause blurred vision, trouble with light it will glare to those effected. You may get buzzing in the ears. It can cause bipolarism, autism , schizophrenia, dissociative behavior and tunnel vision among many other issues.

Most things like metabokic issues , oxidative stress, autoimmunity that I mention in here I have posted on and you can find it using the search feature in my blog.

NMDA Receptors

Information on how the NMDA receptor functions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1760733/

L-glutamate or glutamic acid is one of the most important of the excitatory neurotransmitters. It is released by many different types of neurons and stimulates other neurons at the synapses. The excitatory neurotransmitters act to stimulate the next neuron to fire.

Excitotoxicity is when levels of excitatory neurotransmitters are to high, at which point the level of neuronal activation or induced firing of neurons becomes damaging.

GABA inhibits firing of neurons. GABA is synthesized from glutamine. It needs the active form of B6, pyridoxal phophate. When there have been inhibitions in metabolic pathways the body may not be able to convert the B6 to the active form causing a build up of glutamine or glutamate. This can lead to dysfunction in the brain. It can also lead to high ammonia levels. Raised ammonia levels can kill our good gut bacteria and let the sulfur digesting and methane producing bacteria increase in numbers. This will also happen in the bladder. Also high ammonia levels will make candida go from commensal to pathogenic form. This will cause high sulfite levels which will interfere with BH4, I discussed earlier the problems that creates. The high sulfite levels can also cause problems with the CBS pathway which can eventually effect the Krebs Cycle.

GABA and glutamate are balanced in the brain . P5P deficiency can result in elevated glutamate to GABA ratio in the brain which results in elevated levels of exitotoxicity.

https://www.ncbi.nlm.nih.gov/pubmed/17127302

Taurine performs manby vital functions in the body including nutritional metal transport into the cells.

L-glycine is an inhibitor of neurotransmitter.

N-Methyl-D-Aspartate (NMDA) receptors found in various nerve cells or neurons in the brain. They are stimulated by glutamate and aspartate (aspartic acid). There are 4 main types of of neurotransmitters. NMDA, AMPA, Kainate and Metabotropic receptors.

NMDA primary role is to respond to glutamate or aspartate. NMDA is also stimulated by glycine and polyamines. Aspartate is also involved in the Krebs cycle. Polyamines are interesting, they do not know a lot about them but from what I have read they are almost like software that will zip or compress files then decompress them. They also have a lot of other functions.

Post synaptic NMDA receptor hyper excitement by the presence of elevated glutamate and aspartate levels and/or insufficient GABA, Taurene or Glycine levels results in the receptor opening a channel in the cell membrane allowing the influx of calcium (Ca2+) ions and a reduction of potassium (k+) ions. This has been linked to many brain disorders and it is a common theme in a variety of disorders effecting the brain. The influx of calcium into the cells stimulates NOS leading to NO production in post synaptic cells. I discussed eNOS and iNOS in my post on Nitrosative Stress. Most of the NO production in the NMDA receptor is from nNOS. This can increase peroxynitrite levels because of elevated superoxide levels from oxidative stress. This can damage the brain and blood brain barrier. This can also deplete ATP , when ATP levels are low the NMDA receptors become hyper sensitive.

When the NMDA receptor is hyper sensitive a person will become sensitive to many thing, sound, light, certain odors especially toxic ones. It can make a person sensitive to chemicals because of the over stimulation.

problems with the NMDA recptor can cause the immune system to be inhibited

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586474/

NMDA issues can also have effects on the heart.

https://www.ncbi.nlm.nih.gov/pubmed/27561785

There is a connection between the NMDA receptor and pancreatic cancer.

https://www.dovepress.com/nmda-receptors-are-important-regulators-of-pancreatic-cancer-and-are-p-peer-reviewed-article-CPAA

Issues with the NMDA receptors can result in chemical sensitivities.

https://www.ncbi.nlm.nih.gov/pubmed/12205032

Copper moduclates the NMDA receptor. When we have an infection our bodies will hide copper in our soft tissue. This can make us appear to be deficient in copper. Vitamin C frees the copper from our soft tissue. Do not take too much, in high doses vitamin C destroys red blood cells. If you are deficient in copper liquid chlorophyll is a good source of copper.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382327/

https://www.hindawi.com/journals/ijad/2011/292593/

https://www.hindawi.com/journals/omcl/2014/147251/

Vitamin C interacts with the NMDA receptor to reduce pain. Has been shown to help with sciatica.

https://www.ncbi.nlm.nih.gov/pubmed/28902622

Most know vaccinations damage the brain.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297824/

http://n.neurology.org/content/86/16_Supplement/P5.136

https://www.ncbi.nlm.nih.gov/m/pubmed/25081016/?i=5&from=%2F26844739%2Frelated

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936221/

It is a good idea to learn the symptoms because damage to the NMDA receptor is common in those vaccinated.

http://pediatrics.aappublications.org/content/138/3/e20160901?download=true

http://www.sciencedirect.com/science/article/pii/S2214250914000262

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297824/

Information on NMDA and supplements that help with NMDA issues.

https://www.wellnessresources.com/news/when-ssris-fail-causes-of-depression-nutrition-for-your-brain

Magnesium and Zinc helps to counter the influx of Ca2+ from the NMDA stimulation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122891/

Restless legs has been caused by high glutamate levels.

http://www.rlcure.com/glutamate.html

High ammonia levels will cause high glutamate levels.

http://www.ucl.ac.uk/~ucbcdab/urea/amtox.htm

Oxidative stress.

https://www.sciencedirect.com/science/article/pii/S1011134417307030?via%3Dihub

https://www.ncbi.nlm.nih.gov/pubmed/16766163

https://www.ncbi.nlm.nih.gov/pubmed/24814387

http://thescipub.com/html/10.3844/ajbbsp.2008.73.84

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881419/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965765/

How the body regulates glutamate levels and how to protect the brain.

https://www.ncbi.nlm.nih.gov/pubmed/26711497

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431845/

http://nancymullanmd.com/glutamate-and-gaba-balance/

http://www.holistichelp.net/blog/how-to-increase-gaba-and-balance-glutamate/

http://www.jneurosci.org/content/25/26/6084

http://dana.org/Cerebrum/Default.aspx?id=39382

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134390/

http://journals.sagepub.com/doi/pdf/10.1177/0300060517693423

https://www.ncbi.nlm.nih.gov/pubmed/25433158

The blood brain barrier.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687937/

Glyphosate, this has been found to be in very high levels in our food supply. They have found the environment is so contaminated that it is even in the air and rain. So almost all have glyphosate in them.

https://www.ncbi.nlm.nih.gov/pubmed/28627408

https://www.sciencedirect.com/science/article/pii/S0300483X14000493

Inflammation

https://neuroshaman.wordpress.com/2016/01/23/kynurenic-acid-a-factor-for-schizophrenia-and-autism/

BH4 and autism.

https://autismmasterycourse.com/wp-content/uploads/2016/08/Neurochemical-Imbalances-and-Autism-Tetrahydrobiopterin-Metabolism-and-Quinolinic-Acid-Toxicity.pdf-8-15-16.pdf

The NMDA receptor has been tied to interstitial cystitis.

http://inter-use.com/Journals/JSAB/2015/Volume_03_Issue_04/2015/0507/96.html

Brain and gut.

https://www.wellnessresources.com/news/when-ssris-fail-causes-of-depression-nutrition-for-your-brain

https://link.springer.com/article/10.1007/s00787-017-1056-1

https://www.ncbi.nlm.nih.gov/pubmed/9881820

https://www.ncbi.nlm.nih.gov/pubmed/29090837/

https://www.ncbi.nlm.nih.gov/pubmed/20359266

https://www.nature.com/articles/nature22075

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068444

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879184/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228144/

https://www.selfhacked.com/blog/gut-bacteria-microbiome/?utm_source=ActiveCampaign&utm_medium=email&utm_content=ICES%2FPEMF%2C+Ceylon+Tea%2C+Gut+Microbiome+Affects+%2B+Management%2C+Purple+Sweet+Potato%2C+Myostatin%2C+Hyperbaric+Oxygen+Therapy&utm_campaign=Mar42018+Newsletter

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040025/

https://www.cell.com/cell/fulltext/S0092-8674(15)00248-2

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169303

https://www.researchgate.net/publication/312447778_Lactobacillus_plantarum_CCFM639_can_prevent_aluminium-induced_neural_injuries_and_abnormal_behaviour_in_mice

https://thevaccinereaction.org/2016/09/role-of-the-microbiome-in-infant-development/

https://www.ncbi.nlm.nih.gov/pubmed/18283240

https://kresserinstitute.com/gut-circadian-rhythm-connection/

https://www.honeycolony.com/article/trust-your-gut-health/

http://www.greenmedinfo.com/blog/vaccine-injury-first-gut-then-brain

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572414/

GMOs and the farm chemicals used on them cause leaky gut. This is a cause of autism.

https://molecularautism.biomedcentral.com/articles/10.1186/s13229-016-0110-z

https://www.theunion.com/news/twi/glyphosate-roundup-and-its-link-to-celiac-disease-gluten-intolerance/

https://detoxproject.org/glyphosate/glyphosate-and-roundup-negatively-affect-gut-bacteria/

http://autismcoach.com/glyphosate-folic-acid-oxalic-acid-vaccines-and-tylenol-wreak-metabolic-havoc-together/

https://www.ncbi.nlm.nih.gov/pubmed/25883837

https://www.cell.com/cell/fulltext/S0092-8674(16)30730-9

http://journals.sagepub.com/doi/pdf/10.1177/0300060517693423

Getting GMOs out of the diet helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550406/

http://www.autismone.org/content/autism-explained-synergistic-poisoning-aluminum-and-glyphosate-stephanie-seneff

https://www.youtube.com/watch?v=kzHXuMIsZTA

http://www.mdpi.com/1099-4300/15/4/1416

Our toxic food.

https://bebrainfit.com/neurotoxins-foods/

https://chriskresser.com/beyond-msg-could-hidden-sources-of-glutamate-be-harming-your-health/

http://www.holistichelp.net/toxins.html

https://www.dementia.org/study-links-diacetyl-to-alzheimers-disease

https://www.sciencedirect.com/science/article/pii/S0300483X14000493

Our parents past can have effects on our brain.

https://www.whatisepigenetics.com/a-fathers-stress-felt-for-generations/

https://www.madinamerica.com/2013/05/starvation-what-does-it-do-to-the-brain/

http://europepmc.org/articles/PMC4333222

How infection causes NMDA issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635055/

https://www.ncbi.nlm.nih.gov/pubmed/28484451

Our environment.

https://www.ncbi.nlm.nih.gov/pubmed/26721368

http://www.chemtrust.org/brain/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914412/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428475/

Proton Pump inhibitors damage the brain.

https://jamanetwork.com/journals/jamaneurology/fullarticle/2487379?utm_source=facebook&utm_medium=social_jamaneur&utm_campaign=article_alert&utm_content=automated

Endotoxins can contribute to NMDA excitability. Astaxanthin helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746928/

https://docs.google.com/document/d/19UH1Jfe0qlPrKunC36yZVXZcuRLx_f8MslQdSXkV8pA/mobilebasic

https://autismrecoverytreatment.com/autism-treatment-–-quinolinic-acid-and-autism/

A number of autism studies and causes.

https://medel-la-production.s3.amazonaws.com/uploads/attach_document/document_file/59cda6fe69702d2351c80600/autism-studies-april-2008-2.pdf

Over active immune response which can be caused by tick born illness, vaccinations or glyphosate.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921406/

Inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753746/

http://www.cytokines-and-depression.com/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535916/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961620/

Inflammation from Lyme can even cause aneurysms.

https://jnnp.bmj.com/content/64/5/636

https://www.madinamerica.com/2017/03/lyme-wake-up-call/#comment-125698

https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-5-40

https://www.ncbi.nlm.nih.gov/pubmed/24604078

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481283/

https://www.linkedin.com/pulse/your-brainon-lyme-lori-dennis-ma-rp/?trk=prof-post

Oxidative stress

http://www.eurekaselect.com/101108/article

Immune system

https://reliawire.com/immune-system-social-behavior/?utm_content=buffer5f170&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

https://www.ncbi.nlm.nih.gov/pubmed/23867105

http://neurosciencenews.com/schizophrenia-immune-disorder-bipolar-8179/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143489/

Encephalitis is part of the illness.

https://aealliance.org/patient-support/symptoms/

http://www.pandasnetwork.org/wp-content/uploads/2013/07/Autoimmune_encephalitis.pdf

Brain being deprived of cholesterol. This shows how statins cause it but metabolic issues can also cause this.

https://www.westonaprice.org/health-topics/modern-diseases/dangers-of-statin-drugs-what-you-havent-been-told-about-popular-cholesterol-lowering-medicines/

https://www.medicalnewstoday.com/articles/321115.php

http://www.greenmedinfo.com/blog/underreported-dangers-low-cholesterol

https://www.theautismexchange.com/organized-information/biomedical/conditions/low-cholesterol

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005588/

https://www.ncbi.nlm.nih.gov/pubmed/?term=PMC5806328

https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-016-0877-8

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487843/

This I have researched it is caused by oxidative stress from toxins.

https://www.medel.la/card_collections

Fluoride damages the brain.

https://www.researchgate.net/publication/291795479_Effects_of_endemic_fluoride_poisoning_on_the_intellectual_development_of_children_in_Baotou

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997496/

https://www.hsph.harvard.edu/news/features/fluoride-childrens-health-grandjean-choi/

https://www.ncbi.nlm.nih.gov/pubmed/25577494

https://www.ncbi.nlm.nih.gov/pubmed/25556215

Fluoroquinolone drugs destroy the brain.

https://floxiehope.com/2015/06/13/hacking-fluoroquinolone-toxicity-via-the-nervous-system/

Reversing autism

https://www.youtube.com/watch?v=m2PyRhOSYBY

http://healing-arts.org/children/mtpromotion.htm

Certain metabolic issues caused by toxins, infection or nutrient deficiencies can cause high ammonia levels which can lead to brain injury. These can be caused by nutrient deficiencies, toxins, vaccine injury, inflammation, over active immune system or infection. Many studies have connected metallothionein deficiency with autism.

http://www.neuroradiologycases.com/2012/02/hyperammonemic-encephalopathy-mri.html

https://academic.oup.com/ajcn/article-abstract/80/6/1611/4690493?redirectedFrom=fulltext

http://www.cease-therapy.com/treatment/metallothionein/

https://epidemicanswers.org/metallothionein-and-autism-2/

https://www.psy-journal.com/article/S0165-1781(13)00737-3/fulltext

https://www.hindawi.com/journals/omcl/2017/5828056/abs/

These metabollic issues can be caused by vaccine injury and glyphosate.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028461/

https://www.ncbi.nlm.nih.gov/pubmed/17127302

https://www.westonaprice.org/health-topics/environmental-toxins/violent-behavior-a-solution-in-plain-sight/

https://www.tandfonline.com/doi/abs/10.1080/1028415X.2017.1423268?journalCode=ynns20

Low CoQ10 can contribute but under certain circumstances it could increase oxidative stress making things worse. So I would so address the issues causing the low CoQ10 before taking it.

https://www.ncbi.nlm.nih.gov/pubmed/20010493

Mast cell activation can cause a number of illnesses.

http://www.mastcellaware.com/mast-cells/related-conditions.html

https://www.prohealth.com/library/study-shows-that-mast-cell-activation-a-disorder-common-in-lyme-disease-causes-depression-5478

http://planetthrive.com/2010/12/the-alkaline-brain/

Spinal fluid leak can be caused by fluoroquinolones or tick born illness.

http://spinalcsfleak.org/

Mercury can cause problems with the NMDA receptor. They claim it is not in vaccinations but that is a lie some still contain it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241260/

https://www.nature.com/articles/4001529

They try to blame genetics for mercuries effects on the NMDA receptor.

https://www.nature.com/articles/4001529

Serine helps.

https://pubs.acs.org/doi/10.1021/acs.jafc.7b04217

vitamin B6 helps by reducing brain inflammation.

http://www.hormonesmatter.com/reducing-brain-inflammation-vitamin-b6/

Ashwanga enhances memory through the NMDA receptor.

https://www.ncbi.nlm.nih.gov/pubmed/23711138

If the body is not producing enough endocanabinoids , phytocanabinoids my help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342457/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877778/

Sarcosine helps with NMDA issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921092/

https://jamanetwork.com/journals/jamapsychiatry/fullarticle/209027

D3 also helps reduce psychosis through the NMDA receptor.

https://www.ncbi.nlm.nih.gov/pubmed/12842123

Those with anti-NMDA antibodies have been found to be low in vitamin D.

https://www.ncbi.nlm.nih.gov/pubmed/27836631

The NMDA receptors help regulate glucose homeostasis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903398/

http://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(15)00248-9

Fasting reverses some aging in the brain through NMDA.

http://www.jneurosci.org/content/27/38/10185

PQQ helps with nuerotoxic injury.

https://www.ncbi.nlm.nih.gov/pubmed/1318959

https://michaelrucker.com/glutamate/pqq-glutamate-nitric-oxide-and-n-methyl-d-aspartic-acid-receptors/

Cat’s Claw helps with NMDA issues.

https://www.ncbi.nlm.nih.gov/pubmed/15531384?dopt=Abstract

Not sure what Acorus is but it helps with NMDA issues.

https://www.ncbi.nlm.nih.gov/pubmed/11253173?dopt=Abstract

Psychotria Colorata helps with NMDA issues and opioid addiction.

https://www.ncbi.nlm.nih.gov/pubmed/11417913

Huperzia serrata contains huperizine A which helps with alzheimer’s

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137276/

Aspertame an atrificial sweetener can cause damage to the NMDA receptors.

https://www.globalhealingcenter.com/natural-health/health-dangers-of-aspartame/

MSG also has a negative impact on the NMDA receptors.

https://www.researchgate.net/publication/303458692_The_effects_of_monosodium_glutamate_and_aspartame_on_rat_hippocampal_N-methyl-D-aspartate_receptor_subunits_and_oxidative_stress_biomarkers

Muscarinic

Muscarinic receptors are G-protein (molecular switches) coupled acetycholine receptors. They are found on the outer membrane of certain neurons and cells. There are five types of Muscarinic Acetylcholine receptors (mACHRs). M1-M5 , when the odd numbered receptors are stimulated they produce increased levels of cytoplasmic (material within a cell) calcium ions in the cell. The odd number receptors trigger synthesis of a chemical messenger IP3 (inositol triphosphate-a phytate) which releases intercellular calcium stores from certain calcium stores that have been sequestered away in the cell. The increased cellular calcium concentration will lead to increased NO production by nNOS and eNOS this can lead to high peroxynitrite levels.

Over stimulation of mACHRs from farm chemicals and many other toxins like heavy metals cause high acetycholine levels by inhibiting acetylcholesterase enzyme which breaks down acetylcholine. This causes high levels of acetycholine which causes the release of NO leading to the production of peroxynitrite. Excessive supplementation of DMAE or Centrophenoxine which has a DMAE component can result in elevated acetylcholine. This can also lead to excess inflammation throughout the body because it is involved in reducing inflammation.

High acetylcholine levels can cause anxiety and high risk taking behavior and mood swings.

http://www.pnas.org/content/103/13/5219

Scopolamine found in belladonna can inhibit muscarinic excitability.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3285663/

Nutrients for the muscarinic receptors.https://ecommons.aku.edu/cgi/viewcontent.cgi?referer=https://swisscows.com/&httpsredir=1&article=1032&context=pakistan_fhs_mc_bbs

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2011.07616.x

Mugwort helps

https://ecommons.aku.edu/cgi/viewcontent.cgi?referer=https://swisscows.com/&httpsredir=1&article=1032&context=pakistan_fhs_mc_bbs

Tylenol autism.

https://vactruth.com/2016/06/25/acetaminophen-and-autism/

https://safeminds.org/news/data-points-acetaminophen-exposure-children-potentially-inducing-autism/

Psychological Stress or Trauma

Psychological stress or trauma causes high NO levels which can lead to high peroxynitrite levels which is very damaging to the brain and body. iNOS is upregulated in the lungs and liver during stress. High iNOS levels have been found to be common in post traumatic stress disorder and many illnesses involving chronic fatigue. iNOS is also unregulated during physical trauma which makes those who have been abused more susceptible to chronic fatigue disorders.

Vaccinations and NMDA

It is stated on many vaccine inserts that brain swelling is a side effect. Vaccinations have a dramatic impact on the NMDA and Muscarinic receptors causing the above mentioned things. If you look up the symptoms of autism you will see that brain swelling is the main symptom. But the pharmaceutical companies play the rename game. When people start figuring things out they will rename an illness. They now call it encephalopathy. They played this very game when people figured out that Gulf War Syndrome was caused by vaccinations. They now call it ASIA syndrome.

Aluminum is in vaccines.

https://www.frontiersin.org/articles/10.3389/fneur.2014.00212/full

https://www.ncbi.nlm.nih.gov/m/pubmed/6135334/

https://cdn2.hubspot.net/hubfs/519118/Content%20Offerings/Summary%20of%20Studies%20Featured%20in%20Vaccines%20and%20Autoimmunity%20.pdf

http://www.greenmedinfo.com/article/study-found-increased-asd-risk-among-children-whose-mothers-received-influenza

http://www.ageofautism.com/2010/05/peer-reviewed-papers-support-findings.html

https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-11-149

https://arupconsult.com/content/n-methyl-d-aspartate-nmda-type-glutamate-receptor-autoantibody-disorders

https://link.springer.com/article/10.1007%2Fs12026-016-8855-1

http://circleofdocs.com/30-solid-scientific-studies-that-prove-vaccines-cause-autism/

https://medel-la-production.s3.amazonaws.com/uploads/attach_document/document_file/59725b7269702d07c0bf0000/Acute_Disseminated_Encephalomyelitis_After_Influenza_Vaccination.pdf

https://www.sciencedirect.com/science/article/pii/S0946672X17308763

https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-19-51

https://www.hindawi.com/journals/jt/2014/491316/

https://www.ncbi.nlm.nih.gov/pubmed/944354

https://www.ncbi.nlm.nih.gov/m/pubmed/24996055/

https://www.ncbi.nlm.nih.gov/pubmed/21058170

https://jamanetwork.com/journals/jamapediatrics/article-abstract/2617988

http://www.globalresearch.ca/mitochondrial-collateral-damage-thanks-to-big-pharma/5447650

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1112717/

https://www.ncbi.nlm.nih.gov/pubmed/15265850

http://www.ageofautism.com/2010/07/new-study-shows-vaccines-cause-brain-changes-found-in-autism.html

https://jamanetwork.com/journals/archneurpsyc/article-abstract/647602#nav

https://www.jocn-journal.com/article/S0967-5868(08)00189-6/fulltext

http://www.vaclib.org/links/jockslinks.htm

They claim mercury has been removed from vaccines but that is a lie because some still contain it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705731/

https://www.ncbi.nlm.nih.gov/pubmed/23843785

https://www.ncbi.nlm.nih.gov/pubmed/16870260

https://www.ncbi.nlm.nih.gov/pubmed/19357975

https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(13)70278-3/abstract

https://www.globalresearch.ca/big-pharma-prescribed-drugs-or-vaccine-induced-dementia-is-not-alzheimer/5628607

http://www.greatergoodmovie.org/learn-more/science/brain-inflammation-encephalitis-post-vaccination/

https://www.hopkinsmedicine.org/news/media/releases/brain_inflammation_a_hallmark_of_autism_large_scale_analysis_shows

https://www.ncbi.nlm.nih.gov/pubmed/22015705

https://www.mcleanhospital.org/news/mclean-hospital-neuroscientists-find-immune-system-newborns-may-affect-developing-brain

https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/2047-9158-3-16

https://www.ncbi.nlm.nih.gov/pubmed/21549155

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173748/

https://web.archive.org/web/20150210051051/http://www.ashotoftruth.org/history

Autoimmunity.

http://journals.sagepub.com/doi/abs/10.1177/0961203311429550?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Toxins cause oxidative stress which leads to brain injury.

https://www.researchgate.net/figure/Methionine-synthase-links-oxidative-stress-to-epigenetic-regulation-Figure-4-shows-how_fig4_223971780

Nutrients that help.

http://www.mdpi.com/2072-6643/10/3/369

Saffron can help with the effects of these things.

https://www.sciencedirect.com/science/article/pii/S094471131400364X?via%3Dihub

https://www.ncbi.nlm.nih.gov/pubmed/21623535

Increasing Ghrelin may help.

https://www.selfhacked.com/blog/ghrelin-role-cognitive-gut-function-weight-inflammation-autoimmunity/

Melatonin helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571800/

Fish oil helps.

https://draxe.com/fish-oil-benefits-health/

Removing aluminum from the brain.

http://realfarmacy.com/mineral-waters-remove-aluminum-from-brain/

Black Sativa helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642442/

Having pets helps.

https://www.nih.gov/news-events/news-releases/animals-presence-may-ease-social-anxiety-kids-autism

Corn silk helps but must be organic. The BT Toxin and glyphosate in GMOs have been shown to cause autism.

https://innovareacademics.in/journals/index.php/ijpps/article/view/6943

Anise oil helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416669/

orthosilicic acid may help or silica

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546016/

https://www.ncbi.nlm.nih.gov/pubmed/3743228

To increase my brain glycogen levels in the morning I started using maple syrup, honey or organic unsulfured blackstrap molasses.

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2004.02421.x

Luteolin helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490655/

Niacin may help.

http://blog.healthybynaturehwc.com/niacin-deficiency/#comment-1287

Wild violet helps with insomnia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341349/

Some natural therapies that helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994794/

https://feingold.org/

Ebselem helps by reducing oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759215/

Ferulic Acid found in wheat bran and angelica helps.

https://www.sciencedirect.com/science/article/abs/pii/S0031938416308691

Sulfur and autism.

https://www.blants.com.au/autism.html

Flaxseed increases MAO release which may help.

http://journals.sagepub.com/doi/abs/10.1177/0960327115571765

Tryptophan my help with some but there are certain metabolic issues this could make worse.

https://www.ncbi.nlm.nih.gov/pubmed/11336160

St. Johnswort may help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736901/

Plants that may help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597072/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452207/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210916/

Plants that help reduce acetycholine.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518125/

Honeysuckle may help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492671/

Metallothein helps.

https://metabolichealing.com/metallothionein-forgotten-antioxidant-missing-puzzle-piece-for-alzheimers-leaky-gut/

Lionsmane mushroom helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583117/

Gingko really helped me but the first couple of times I took it, it gave me a headache. It you take it for too long it can damage the liver. But certain vitamins can do that.

https://www.jstage.jst.go.jp/article/bpb/37/2/37_b13-00378/_article

Some herbs that helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459457/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993511/

http://www.encognitive.com/node/6310

Palmitoylethanolamide helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5531370/

Baicalein found in sculletaria, fleabane and plantain herb helps. Helped me a lot.

https://www.ncbi.nlm.nih.gov/pubmed/27518088

Hydroxocolbalamin may help.

https://www.prohealth.com/library/the-brain-boosting-and-fatigue-fighting-b-12-26949

Diet for those with phenylketonuria. I fixed mine.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750587/

Thymus found in savory, juniper berries, thyme, black sativa and bergamot will help.

https://www.ncbi.nlm.nih.gov/pubmed/24814387

Passion flower helps but I have seen studies that make me question the safety of it’s long term use. I would only use when needed.

https://www.ncbi.nlm.nih.gov/pubmed/27693740

Self heal helps.

https://onlinelibrary.wiley.com/doi/10.1002/ptr.4929

Pyrroluria is a symptom of porphyria. This will help the pyrroluria part of the symptoms.

https://nutrientpower.wordpress.com/pyrroluria/

For those who have symptoms severe enough to cause convulsions these herbs have been researched.

http://www.eurekaselect.com/152566/article

Tips for reducing brain inflammaton.

http://www.hormonesmatter.com/reducing-brain-inflammation-vitamin-b6/

Rooibos helped me.

https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201300463

Roseroot helps. Actually I looked at the phytochemicals of the whole plant and they are pretty much the same throughout the plant.

https://www.medicalnewstoday.com/articles/291596.php

Quiet time helps.

https://www.lifehack.org/377243/science-says-silence-much-more-important-our-brains-than-thought?ref=facebook

Serrapeptase and nattokinase helps but very high doses can have serious negative health effects.

http://journals.sagepub.com/doi/abs/10.1177/0960327112467040?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

For better sleep.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008810/

Pyrroloquinoline Quinone helped me a lot with healing.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303106/

N-acetylcysteine helped me.

https://www.optimallivingdynamics.com/blog/the-powerful-antioxidant-proven-to-treat-6-mental-illnesses

Hops was another one that helped me a lot. It has a cannabinoid similar to THC, I react bad to THC but not to hops.

https://akademiai.com/doi/abs/10.1556/APhysiol.99.2012.2.6?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

God info on healing nerves and the brain.

https://www.selfhacked.com/blog/myelin/

Good info on healing children with autism.

http://www.healourlittleones.com/?p=837

Reducing endothelins can helps, this would also help with high blood pressure.

https://www.selfhacked.com/blog/endothelins/?utm_source=ActiveCampaign&utm_medium=email&utm_content=The+Latest+From+SelfHacked&utm_campaign=Jan282018+Newsletter

Cut toxic people out of your life. If they cared they would not be so toxic.

https://themindsjournal.com/why-its-okay-to-cut-toxic-family-members-out-of-your-life/

Thiamine deficiency can cause many health problems.

https://www.livescience.com/51721-vitamin-b1-thiamine.html

Those who are G6PD deficiency or metabolic issues especially porphyria or sulfation issues need to address them because the foods that contain thiamine could make them ill if they do not. They may have to supplement until they have addressed them.

https://draxe.com/thiamine-foods/

https://www.livescience.com/51721-vitamin-b1-thiamine.html

Folic Acid is man made and not good for the body and can cause problems.

https://www.drbenlynch.com/resource/why-you-should-stop-taking-folic-acid/

http://blog.naturalhealthyconcepts.com/2015/05/13/the-difference-between-folate-folinic-acid-and-folic-acid/

https://www.thehealthyhomeeconomist.com/folic-acid-making-us-sick/

https://www.globalhealingcenter.com/natural-health/difference-between-folate-and-folic-acid/

Folic acid has been linked to cancer. Folate has not.

https://breastcancerconqueror.com/the-hidden-dangers-folic-acid-vs-folate/

the gut and cholestokinin

http://www.yourhormones.info/hormones/cholecystokinin/

https://www.selfhacked.com/blog/good-bad-effects-cck/

Trypsin inhibitors increase cholecystokinin.

https://naldc.nal.usda.gov/download/26115/PDF

Things that raise GABA like , mugwort, wormwood and rooibos reduces cholecystokinin levels. High estrogen levels cause high cholecystokinin levels. High dopamine levels increases cholecystokinin. High levels of cholecystokinin causes glutamate toxicity and NMDA toxicity.

https://www.acnp.org/g4/GN401000056/CH056.html

Potatoes increase cholecystokinin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033477/

If not addressed it leads to autism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628252/

 

Meditation now called nuero feedback can help heal the brain.

https://www.frontiersin.org/articles/10.3389/fpsyg.2013.00688/full

https://www.selfhacked.com/blog/neurofeedback/?mpweb=1367-178-19862

There are various meditation technique depending on the desired outcome.

https://www.researchgate.net/publication/41486162_Focused_attention_open_monitoring_and_automatic_self-transcending_Categories_to_organize_meditations_from_Vedic_Buddhist_and_Chinese_traditions._Consciousness_and_Cognition_19(4)_1110-1118

https://www.brainsinternational.com/default/assets/File/Phenotype_%20Johnstone,%20et%20al.pdf

Those who meditate have higher cognitive function and less stress.

https://www.goalcast.com/2017/06/20/healing-power-meditation-brain-health/

Meditation even helps with inflammatory bowel disease. It can turn bad genes off.

https://news.harvard.edu/gazette/story/2015/05/meditation-may-relieve-ibs-and-ibd/

https://www.brainline.org/article/role-mindfulness-meditation-and-prayer-after-brain-injury

Nitrosative Stress

This is not medical advice , I am posting this for educational and informational purposes only. This compliments the other post I did on recovering from endotoxemia.

Nitrosative Stress

Is caused by oxidative stress, inflammaton and infection. Those can also lead to Nitrosative Stress which can cause superoxide, and peroxynitrite which are very damaging to the body especially the brain and nervous system. These are a form of Reactive Nitrogen Species. (RNS) Nitric Oxide dependent reactions lead to formation of RNS through the reaction of Nitric Oxide and O2-, peroxynitrite (ONOOH) is formed and leads to oxidation, nitrosation (addition of NO), or nitration (addition of NO2) .

Nitric Oxide is formed from Nitric Oxide Synthase (NOS) which can also produce O2-. Other sources are Xanthine Oxidase, NADPH oxidase, and Myeloperoxidase. There are three types of NOS, inducible nitric oxide synthase (iNOS, NOS2), endothelium NOS (eNOS, NOS3), neuronal NOS (nNOS, NOS1) They no longer use the numerical references to NOS because it inaccurately described them.

Nitric Oxide is a signaling molecule. When functioning properly it is involved with the homeostasis of our blood pressure. Nitric Oxide is released by the endothelial of the smooth muscle to promote smooth muscle relaxation. This increases the diameter of blood vessels to prevent high blood pressure. Oxidative stress and nitrosative stress can deplete NO causing high blood pressure.

Nitric Oxide has antithrombic effects. So if NO is depleted or production is inhibited by free radicals then excessive blood clotting can occur. Impaired NO production can lead to hypertension, preclampsia, diabetes, obesity, erectile dysfunction, and migraine headaches.

NO is generated as a normal part of an immune response. White blood cells known as phocytes have both inducible and inhibitory enzymes to control NO. NO secreted as part of the immune response uses NOS free radical properties and it is toxic to bacteria, causing DNA damage and degredation of the iron sulfur center.

NO increases expression of superoxide dismutase which catalyzes superoxide anion to hydrogen peroxide. NO upregulates Heme oxygenase 1 and ferritin expression which reduce anion concentrations in blood vessels. This prevents blood vessels from leaking. Inflammation , endotoxins, farm chemicals and many other things can inhibit this. This leads to hardening of the arteries because the body will use cholesterol and calcium to plug the leaks.

NO helps convert thiol groups including cysteine residues in proteins, to form s-nitrosothiols. Thiols are organo sulfur compounds. Our bodies need sulfur for many things and all cell need it. If sulfite levels get high from BH4 , CBS issues, gut dysbiosis or candida it could interfere with the proper function of the thiol groups. S-nitrosylation is an important mechanism for dynamic, post translational regulation of most all major classes of proteins. Post translational regulation is control of gene expression.

Guanylyl known as the NO receptor. Activate guanylyl cyclase enables the production of the cyclic guanosine monophosphate (cGMP) . cGMP activates and regulates the enzyme G-kinase. G-kinase modifies proteins in cell through phosphorylation of the myosin light chain kinase which causes smooth muscle relaxation.

Chronic expression of NO can lead to cancer of the epithelium, juvenile diabetes, multiple sclerosis, arthritis, and ulcerative colitis. NO is an oxidising free radical and does cause some oxidative stress on the bodies membranes and tissues. Sustained No production can result in tissue toxicity but most damage is caused from NO causing peroxynitrite formation.

NO protects organs from ischemia, but can contribute to reperfusion injury by increasing inflammation and oxidative damage.

NO forms complexes with transitional metal ions, including those regularly found in metalloproteins. The main trap for no is oxyhemoglobin (oxygen loaded form of hemoglobin) , which binds to NO faster then oxygen. The reaction produces methaemoglobin other NO sensitive metalloproteins are NOS, Cytochrome P450, Ferritin, Ceruloplasmin, mitochondrial respiratory chain. NOS is discussed later, Cytochrome P450 is a very important for detoxing the body. Ferritin helps regulate iron homeostasis. Ceruloplasmin is a copper-carrying protein that is involved in iron metabolism. Mitochondrial respiratory chain is involved in cellular energy.

As NO rises it oxidizes hemoglobin. In healthy individuals about 1% of total hemoglobin has been oxidized mainly by NO. Excess oxidative stress causes excess NO. which can make methemoglobin higher. Methemoglobin contains Fe3 which cannot bind to oxygen. Curcumine and Lactoferrin reduces Fe3 levels in the body. Curcumin can make you anemic if taken for too long because it can also chelate the good iron from the body. Excess methemoglobin is called acquired methemoglobinemia. This can cause skin discoloration, shortness of breath, lethargy, headache, dizzyness, brain fog. Methylene blue helps with this because it is caused by sepsis but those who are G6PD deficient cannot take methylene blue it could kill them.

Some causes of high NO levels.

Prolonged or frequent immune system activation. Which is common in those with CFS, MS, and Fibromyalgia. The most common cause is viral infection. But any number of infections can cause this especially mycoplasma. So to reduce peroxynitrite levels it is important to reduce the viral load on the body, calm the immune system and reduce inflammation.

Inflammation and pro-inflammatory cytokines.

Effects of low NO levels

Low levels of NO will cause low levels of ATP which means the cells would have less energy. This also disables autophagy preventing recycling of mitochondria.

iNOS

NOS is calcium dependent. iNOS is primarily expressed in macrophages a type of white blood cell of the immune system that engulfs and digest cellular debris, foreign substances, microbes, cancer cells and any other cell that does not the type of proteins specific to healthy cells. They are found in almost all tissues in the body. They are expressed primarily after induction by cytokines(small proteins involved in cell signaling) , especially IFN-Y and lippopolysaccharide (endotoxins) . Lippopolysaccharide is abbreviated LPS. Because iNOS contributes to inflammation and destroys parasites and infections it is a major contributor in septic shock. Excessive iNOS can lead to vascular permeability.

Reactive oxygen species works together with reactive nitrogen species to damage cells. Reactive oxygen species produces hydrogen peroxide which can be very damaging to the body. Reactive nitrogen produces peroxynitrite which is also very damaging to the body. Normally the body can neutralize them but when under excess oxidative stress from emotional stress, physical stress, infection, toxins or from nutritional deficiencies the body cannot neutralize and detox the reactive nitrogen and reactive oxygen species. It is a cycle that can be difficult to break. The inflammation that is caused prevents the body from being able to detox and also the metabolic issues it causes puts an even heavier burden on the body because it produces toxins adding to the burden. This is why it is very important to address the nutrient deficiencies caused by illness or toxins and to reduce inflammation.

eNOS

Endothelial NOS (eNOS) is primarily responsible for the generation of NO in vascular endothelium. Endothelium is a monolayer of cells lining the interior surface of blood vessels. No produced by eNOS in the vascular endothelium plays a crucial role in regulating vascular tone, cellular proliferation (process that results in an increase in the number of cells), leukocyte adhesion (white blood cell), and platelet aggregation. eNOS is dependent on calcium and synthesizes NO from L-arginine and oxygen which binds to the heme group of eNOS. Heme is the part of red blood cells that contain the iron which is needed to transport oxygen. The binding of Tetrohydrobiopteran (BH4) is essential for eNOS to generate NO. In the abscense of BH4 which many toxins like glyphosate, mercury and endotoxins can cause eNOS shifts from a dimeric to a monomeric form, thus becoming uncoupled. This causes a production of superoxide anion by eNOS instead of NO. It is a highly reactive free radical that damages the cardiovascular system. This also causes phenylketonuria, ammonia build up in the body because phenylalanine can no longer be recycled. Eating things high in phenylalanine like meat or potatoes will increase the ammonia levels making a person suffering from this sicker, their urine will get dark and smell and when very bad their body odor will be strong.

eNOS causes a reduction in Cationic Amino Acid Transporter 2 (Cat2) which mediates the L-arginine transport needed for raised NO production.

When functioning properly eNOS prevents hardening of the arteries and damage of the blood vessles. It has anti-artheriosclerotic effects. Oxidative stress can cause it to become uncoupled causing many health problems because this also increase reactive oxygen species. This is the one that will cause issues throughout the body because many metabolic pathways will be effected. There are natural ACE inhibitors that will reduce the damage when this happens. Remember the goal is homeostasis. Once the issues that have caused it’s uncoupling have been addressed focus on healing. To continue to take allopathic or natural things to treat symptoms keeps you on a hamster wheel because you have to address the cause. Treating the symptoms will not resolve the problem it will only reduce the symptoms. Enos is very important to the healing of soft tissue throughout the body so it is very important for all pathways to be functioning. Through indirect processes fluoroquinolones also inhibit BH4 and interfere with eNOs. BH4 is involved in the production of serotonin, and L-Tyrosine so inhibition or uncoupling can have dramatic effects on our brains.

Neuronal NOS

Neuronal NOS which used to be known as NOS1 is constitutively(always active) expressed in the central(brain and spinal cord) and peripheral (nerves throughout the rest of the body) neurons and some other cell types.

nNOS functions include synaptic plasticity in the Central Nervous System, central regulation of blood, and vasodilation via nitrergic nerves.

Peroxynitrite

Peroxynitrite is formed when NO reacts with superoxide (O2-) which it readily combines with. The higher the levels of NO present the great the risk of it reacting with super oxide to form peroxynitrite. Peroxynitrite can cause oxidation to hemoglobin causing anemia.

When peroxynitrite is formed it depletes the bioactivity of NO which effect the bodies ability to regulate blood pressure, platelet activation, and vascular cell signaling. This can result in high blood pressure, and hardening of the arteries. When NOS enzymes have limited L-arganine or BH4 they my produce superoxide instead of NO. The can be transformed to peroxynitrite. BH4 reacts with peroxynitrite and is oxidized to biopterin. BH4 is also oxidized by neopterin which is an indication of an immune response. This causes inflammation which in turn can stimulate more peroxynitrite synthesis.

Peroxynitrite can react with other components of the cell including lipids(fats), thiols(organosulfur compounds) , amino acid residues(an amino acid contained within a peptide or protein) , DNA bases (adenine, cytosine, guanine,thymine) , and antioxidants.

Peroxynitrite can react with other molecules to form additional types of RNS including nitrogen dioxide (N2O2) as will as other chemically reactive free radicals which include peroxynitrous acid, hydroxyl radical, carbon dioxide, carbanate radical and dinitrogentrioxide.

Peroxynitrite can react directly with proteins that contain transition metal centers. Therefore it can modify proteins such as hemoglobin, myoglobin, and cytochrom C by oxidising heme into it’s corresponding ferrous forms. Two of the most common reactions is cystein oxidation and tyrosine nitration. These reactions affect protein structure and function so have the potential to cause changes in the catalytic activity of enzymes, altered skeletal organization and impaired cell signal transduction. So it can hinder the bodies ability to heal and examples of illnesses caused by changes in the catalytic activities of enzymes are illnesses such as porphyria and phenylketonuria. Also with the cells ability to communicate impaired all heck can break loose.

Both NO and peroxynitrite can oxidize the iron-sulfur protein based enzymes in the Krebs cycle (citric acid cycle). The iron-sulfur protein is known as Aconitase. Krebs cycle is involved in producing cellular energy. It is the metabolic pathway that connects carbohydrate, fat and protein metabolism. So problems with this pathway would have dramatic effects throughout the body. So we can see the importance of reducing peroxynitrite levels.

No reacts with nitrogen dioxide (NO2) presumably instead of superoxide to form Dinitrogen Trioxide (NO3) , which is a type of reactive nitrogen species. All nitrogen oxides are good oxidizing agents. This cause excess Cyclic GMP, vascular collapse and septic shock, s-nitrothiol formation on proteins (thionitrites).

Now you should be able to see why iNOS has been implicated in inflammatory bowel disorders.

GTP cyclohydrolase increases BH4, folate is needed to produce it. Do not take folic acid it is man made and can build up in the body causing health problems.

Vitamin C the real vitamin C not man made, Vitamin E and Folate not to be mistaken for Folic Acid which is man made and can build up in the body damaging the NMDA receptor and increasing the risk for cancer. These all scavenge peroxynitrite.

Hydroxycolbamin scavenges peroxynitrite

COX2 inhibitors reduce peroxynitrite. In my list of supplements I listed some things that will inhibit COX.

Getting rid of infection and reducing inflammation reduces peroxynitrite.

Reducing toxins in the body especially glyphosate and heavy metals reduces peroxynitrite.

Ellagic Acid reduces peroxynitrite.

https://www.sciencedirect.com/science/article/pii/S0308814608006195

How Nitric Oxide Species are produced.

https://www.sciencedirect.com/science/article/pii/S0005272899000286

Disregulation of NO can cause many health problems from diabetes to cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345541/

Though I do not agree with statin use because it does more damage to the body then oxidative stress does, this article has a good summary of Nitric Oxide production and the enzymes that regulate it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345541/

iNos has been implicated in inflammatory bowel disease.

https://gut.bmj.com/content/45/2/199

Inflammation and infection are known causes of hardening of the arteries. The blood vessels start to leak and the body uses calcium and cholesterol to seal the leaks resulting in hardening of the artieries. INOS causes leakage in blood vessels in response to inflammation and infection. This is why it is very important to address the infection and inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572034/

Excess iNOS production can cause anemia.

http://jultika.oulu.fi/Record/isbn951-42-6851-2

eNOS issues have been linked to cardiovascular disease, erectile dysfunction, hypertension, diabetes, and obesity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345541/

This is cause by oxidative stress .

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174401/

Toxins and infection can lead to excess NMDA receptor activation which can lead to nitrosative stress.

https://www.researchgate.net/profile/Zezong_Gu2/publication/42441952_Redox_Reactions_Induced_by_Nitrosative_Stress_Mediate_Protein_Misfolding_and_Mitochondrial_Dysfunction_in_Neurodegenerative_Diseases/links/575a2c2e08ae9a9c954f2c86/Redox-Reactions-Induced-by-Nitrosative-Stress-Mediate-Protein-Misfolding-and-Mitochondrial-Dysfunction-in-Neurodegenerative-Diseases.pdf?origin=publication_detail

Epselen can scavenge peroxynititrite but has not been approved for usage for anything but mental disorders.

https://www.sciencedirect.com/science/article/pii/S1054358908609862

Thymoquinone reduces oxidative stress which damages the brain.

https://www.ncbi.nlm.nih.gov/pubmed/28655600

https://www.ncbi.nlm.nih.gov/pubmed/24814387

Baicalein found in sculletaria and plantain herb protects from peroxynitrite damage.

https://www.ncbi.nlm.nih.gov/pubmed/27518088

Dealing With Endotoxemia or Sepsis.

This is not medical advice , I am posting this for educational and informational purposes.

These are my notes of things I researched to recover. I have much more to add to it but figured I would post what I have typed up so far. This is not in order and inflammation is very very important to address in order to be able to detox endotoxins.

https://docs.google.com/document/d/19UH1Jfe0qlPrKunC36yZVXZcuRLx_f8MslQdSXkV8pA/mobilebasic

This is not medical advice, I am putting this here for informational and educational purposes. My advice on reading this because it is very long is skip over things that do not seem to concern you and the issues you are dealing with. I had many health problems I had to deal with and these are my notes. It seems I had more then usual so my notes are extensive. From what I am learning most do not experience the number of health issues I had. I need to cover oxidative stress first because it is the main cause of the symptoms of sepsis.

Many take CoQ10 for their fatigue. I would say it is better to avoid but supporting NADPH might be a better option. I noticed I got worse when I took CoQ10 but Ubiquinol seemed to work fine for me.

https://www.hindawi.com/journals/omcl/2011/194586/

Oxidative Stress

Oxidative Stress is caused by an imbalance in our antioxidant system. When there is an imbalance taking antioxidants will increase the damage in the body. We must address what is causing the imbalance before taking antioxidants. Taking antioxidants when there is an imbalance in the antioxidant system also makes us more prone to health issues especially cancer. An imbalance in or inhibited redox cycling and blocked Nrf2 pathways are the most common issues involving excess oxidative stress.

This results in the production of peroxides and free radicals. This damages components of the cells including lipids and DNA , they cause strand breaks in the DNA preventing it from repairing . This is why high LDL levels are a sign of oxidative stress. High cholesterol indicates an imbalance in the antioxidant system. This can be caused by toxins like heavy metals, the many farm chemicals found in our food, toxins in processed food, heavy metals, infections and the endotoxins from dying pathogens, many of the toxins in vaccinations can cause oxidative stress,and stay in the body a very long time, especially the aluminum in vaccinations. To restore balance we need to detox whatever is causing the imbalance, also address any metabolic issues causing the imbalance. The hydrogen peroxide produced from the reactive oxygen species can act as cellular messengers which cause a disruption in normal mechanism in cell signaling. This causes redox cycling to be inhibited and has been linked to many forms of chronic illness. Nrf2 regulates the antioxidant system and toxins, infection and bad diets can inhibit the Nrf2 pathways. Excess oxidative stress causes adenosine triphosphate (ATP) depletion. ATP is important in molecular cellular energy transfer. This causes apoptic cell death to be inhibited so the cell simply falls apart. When the cell is not removed by apoptosis it can cause a build up of cellular debris in the body which has many negative health effects. Inflammation can inhibit the bodies ability to remove toxins and waste which can contribute to oxidative stress. Over production of ROS can lead to stroke, hypertension, hardening of the arteries, heart attacks, and failure of organs. It can result in damage to the brain resulting in impaired thinking and even mental illness.

There are many sources of reactive oxygen species in the body. Xanthine Oxidase is an enzyme that generates reactive oxygens species it is found in the blood and lungs. It’s activity is increased during infection. Levels of xanthine oxidase are increased during liver damage. It has been found to be high in gout. Phytic acid inhibits xanthine oxidase. Remember homeostasis is the goal because the antioxidant system protects us we do not want to keep inhibiting it. Once we get inflammation down and the peroxide, and free radical levels down we want to maintain homeostasis.

Free radical from oxidative stress deplete cofactors involved in electronic transport, DNA repair. Damaged (Fe-S) clusters can cause iron overload. It also causes inhibition of lipoic acid synthase which is involved in amino acid metabolism and glycine degradation. When inhibited it results in encephalitis and lactic acidosis. This also causes a build up of hydroxyl radicals. NADPH oxidase is activated by infections and certain cytokines. Arachidonic acid (omega 6) also stimulates activity of NADPH oxidase Apocynin found in many plants inhibits NADPH oxidase. I do not know which plants but most research papers state apocynin found in many types of plants. Inhibition of NADPH can cause granulomas to form. This is the bodies way of blocking off something it cannot rid from the body. So do not over do it. Nitric Oxide also inhibits NADPH oxidase. Arginine and citrulline can help increase NO.

http://www.mdpi.com/1420-3049/18/3/2821/htm

Superoxide Dismutase

Superoxide Dismutase comes in three forms in the body, SOD1 is located in the cytoplasma inside of cells, SOD2 located in the mitochondria, SOD3 is extracellular. SOD serves as a key antioxidant. Low SOD levels increases the risk of cancer. SOD has anti-inflammatory effects. SOD decreases ROS and oxidative ss, and interstitial cystitis. It also reduces inflammation in the urinary tract. SOD also prevents liver and kidney damage and protects us from radiation damage. The most bioavailable form of of SOD is found in the chaga mushroom but it is also found in phytoplankton, horseradish, and cantaloupe. If you have iron toxicity it will inhibit SOD. Lactoferrin helps restore the bad iron back to good and helps the body get rid of excess iron. Curcumine chelates iron but if taken to often or too much it can cause anemia. Infection can cause the body to store copper in our soft tissue to prevent pathogens from using iron. This also prevents the body from using iron, it kills the pathogen but inhibits SOD production. Natural sources of vitamin C will get the body to release the copper from the soft tissue. High doses of vitamin C can cause red blood cells to break down so don’t get carried away. Also man made vitamin C can cause oxalates. Manganese is needed for SOD production but should not be taken in high doses it can be toxic if we get too much in the body. Zinc is also needed for SOD production , honey is high in zinc.

Low SOD3 can cause acute respiratory distress syndrome which is when fluid leaks into the lungs. It has also been linked to COPD.

Glutathione and SOD are tightly linked so I will cover it next. Resveratrol also activates SOD it is found in grape seed extract.

We need to find balance because high levels of SOD has been show to make us susceptible to certain types of cancer. Homeostasis should be the goal then do things to maintain homeostasis.

http://www.immunehealthscience.com/superoxide-dismutase.html

https://www.selfhacked.com/blog/the-brain-fog-gene-rs4880-or-sod2/

http://jcb.rupress.org/content/early/2018/04/17/jcb.201708007

Glutathione peroxidase

Glutathione peroxidase is a general name for a group of enzymes with peroxidase activity. Gps main biological role is to protect from damage from oxidative stress. GP reduces lipid hydroperoxides to their corresponding alcohols. Lipid hydroperoxides are caused from the oxidative degredation of fats. It mostly effects polyunsaturated fatty acids. There are several documented cases of anemia from GP deficiency, most likely if they measure the Fe3 iron it would be high. The iron in the plasma was probably in a form the body could not us.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159114/

http://omim.org/entry/614164

GPx1 increases reactive nitrogen species ability to cause cell death and can cause insulin resistance. So it is important to make sure reactive nitrogen species are not high.

https://link.springer.com/chapter/10.1007/0-387-33827-6_16

http://www.jbc.org/content/276/46/43004.full

How Nitric Oxide Species are produce.

https://www.sciencedirect.com/science/article/pii/S0005272899000286

This is a link to a more in depth article I did on Nitrosative Stress.

https://iamajuicer.wordpress.com/2018/07/11/nitrosative-stress/

If you have been reading the links in my post you know by now that lipopolysaccharides a component of endotoxins is responsible for the systematic inflammation that endotoxins cause. Lipopolysaccharides are a component of many pathogens.  It is very important to reduce the level of LPS in the body to reduce chances of sepsis which results in chronic illness. LPS can cause a bunch of issues that prevent us from detoxing which causes many other issues. In order to detox LPS we need to address those issues. I am going to place these links here so when you decide the approach you may want to take you can look at nutritional options that may help after you have read the article and get a better understanding of endotoxemia these can be used for a reference.

https://iamajuicer.wordpress.com/2018/06/23/supplement-and-nutrient-information-i-have-accumulated/

https://iamajuicer.wordpress.com/2018/06/26/supplement-and-nutrient-information-i-have-accumulated-part-2/

It is very important to reduce LPS because it has a dramatic effect on our brain. It can cause anxiety, dissociative behavior, emotional dysfunction. It also impairs memory. It can cause fatigue and even disrupt the reproductive cycle. High LPS levels have been linked to things such as diabetes, heart disease, mental illness, cancer, obesity, metabolic disorders, renal disorders, autism, hearing and eye health can be negative impacted. LPS also cause digestive disorders like SIBO, IBD, IBS and dysbiosis. LPS contributes to arthritis and increased allergies. LPS has even been linked to PCOS in women. LPS causes adrenal fatigue. It can cause many skin disorders like lupus or psoriasis. It can contribute to bone loss. It causes neurological damage throughout the body.

Endotoxins also cause hormone imbalances and thyroid problems.

There are gut bacteria that reduce LPS, Bifidobacterium, Lactobacillus GG, Saccharramyces Boulardii Bacillus Infantis, B Longhum, Clostridium Butyricum, E Coli Nissle 1917, Lactobacillus Brevis, L Casei, and many others.

https://www.ncbi.nlm.nih.gov/pubmed/23568206

Fruit pectin reduces LPS. The pectin is the waxy substance found on the skins of many fruits. One of these articles mentions corn flakes. Corn is GMO and causes leaky gut which would make things worse. I do not recommend eating any GMOs they themselves can cause sepsis.

https://www.ncbi.nlm.nih.gov/pubmed/16930561

http://healthyeating.sfgate.com/fruits-high-pectin-9671.html

https://www.dietaryfiberfood.com/dietary-fiber/pectins.php

Exercise reduce LPS.

https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-015-0362-0

Stimulating the vagus nerve decreases LPS and inflammation.

https://www.hindawi.com/journals/ecam/2012/627023/

https://thelivingproofinstitute.com/19-ways-to-stimulate-your-vagus-nerve/

https://theheartysoul.com/ways-to-stimulate-your-vagus-nerve/

Polyphenols reduce LPS. These are usually highest in darker colored fruits and vegetables.

https://academic.oup.com/ajcn/article/79/5/727/4690182

Resistant starch decreases LPS by increasing the good gut bacteria. This should be introduced slowly because when the good gut bacteria increase the bad die off which will cause bloating and herxing. I got very ill when I tried to eat resistant starch. I had to start with small amounts and slowly increase my intake.

http://drhyman.com/blog/2016/03/24/the-starch-that-makes-you-lean-and-healthy/

https://www.karger.com/Article/FullText/477386

LPS and Fats

Diets high in bad fats, like transfats and saturated fats increase the effects of LPS.

These sites suggest ways to reduce LPS. I do not agree with all their methods so always take things with a grain of salt and do your research. Many have metabolic issues that need addressed before taking some of the suggested things in these articles. For example those with high sulfite levels or CBS or BH4 issues would become ill from some of the things suggested because they are high in sulfur. Those with Pyrrole issues will become ill from any types of fats so Omega 3s will cause problems. So before you can even attempt to detox LPS you need to address any metabolic issues or you will be running on a hamster wheel of ill health getting no where because the things needed to heal will make you ill.

https://www.selfhacked.com/blog/lipopolysaccharides/

https://mybiohack.com/blog/lipopolysaccharide-endotoxins-lps-tlr4

LPS Causes Leaky Gut

LPS causes leaky gut, leaky gut causes our bodies to absorb more LPS. Here is another area where the cycle must be broken. Just as with high oxalate levels it is difficult to heal the gut , high LPS levels make it difficult to heal the gut. I have posted articles that will help with information on healing the gut so I will not cover it in detail but if time permits I will post the links to the articles. Healing the gut is very important in order to break the cycle.

https://www.naturalmedicinejournal.com/journal/2010-03/nutritional-protocol-treatment-intestinal-permeability-defects-and-related

https://www.mindbodygreen.com/0-15971/why-a-leaky-gut-will-wreck-your-health-what-to-do-about-it.html

https://www.selfhacked.com/blog/lipopolysaccharides/

These are articles I did that have information that may help with leaky gut.

https://iamajuicer.wordpress.com/2018/06/28/leaky-gut-oxalates-and-more-supplement-information/

https://iamajuicer.wordpress.com/2018/06/27/its-not-your-genes-it-is-your-gut-microbiome/

Activated charcoal helps reduce LPS but should not be taken to soon after eating. It will inhibit nutrient absorption.

https://fixyourgut.com/dysbiosis-causing-illness-try-activated-charcoal/

If the leaky gut is not addressed we develop metabolic endotoxemia.

https://paleoleap.com/metabolic-endotoxemia-one-link-between-gut-problems-and-obesity/

Polyunsaturated fats should be avoided. The body only needs a small amount of them. When the levels get to high in the body they negatively impact our health. These are found in things such as corn oil, canola oil, cotton seed oil, and soybeen oil. They also contain transfats which really need to be avoided. Fats from things like fresh cod liver oil which should be refrigerated. If it smells fishy then it has oxidized and has lost some of it’s benefits, other sources are coconut oil, beef tallow,lard and butter contain the fats that our bodies need. The tallow, lard and butter should be from grass feed beef. We need PUFAs in our diet but in the form of Omega 3s. We have to do our best to prevent the Omega 3s from oxidizing. The previously mentioned oils are high in Omega 6 , our Omega 3 levels should be higher then Omega 3s but processed food is high in Omega 6 and is why many have inflammatory diseases.

http://butterbeliever.com/what-is-pufa/

https://www.medpagetoday.com/primarycare/dietnutrition/50978

It is very important to protect the liver while detoxing endotoxins because it is hit pretty hard and can get damaged. Burdock root and sarsparilla root seemed to help me. Rooibos tea was another herb that really helped me, it is great for oxidative stress and inflammation. Sculletaria is another one that seemed to really help me. Bayberry has also been found to support the kidney and liver.

https://ccforum.biomedcentral.com/articles/10.1186/cc5013

https://www.betternutrition.com/natural-rx/herbaldetox

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-14-392

https://www.sciencedirect.com/science/article/pii/S2221169115001410

Here is a very good article explaining detoxing.

https://www.selfhacked.com/blog/the-science-of-detoxification/

Oxidative Stress

Endotoxins cause oxidative stress which results in the oxidation of lipids. The can result in damage throughout the body and is why many have high oxLDL levels. High LDL is a symptom not a cause. It is very important to also address the oxidative stress caused by endotoxins. This includes restoring the balance of our gut bacteria which protects us from oxidative stress. If they are out of balance they can actually contribute to oxidative stress. It is why those who take the same probiotic daily usually end up sicker. They get too much of specific strains of gut bacteria and are preventing their gut bacteria from balancing out. Cholesterol is an antioxidant and an anti-inflammatory. Reducing cholesterol would do the opposite of what we want. It would increase inflammation and prevent the body from healing.

https://www.researchgate.net/profile/Guillermo_Tellez/publication/286285603_Mechanisms_involved_in_lipopolysaccharide_derived_ROS_and_RNS_oxidative_stress_and_septic_shock/links/569593d908ae425c68985bfa/Mechanisms-involved-in-lipopolysaccharide-derived-ROS-and-RNS-oxidative-stress-and-septic-shock.pdf?origin=publication_detail

https://www.ncbi.nlm.nih.gov/pubmed/27718209

http://atvb.ahajournals.org/content/23/7/1133

Vitamin E reduces oxidative stress from LPS but the most effective is a-tocopherol. A-tocopherol is found in wheat germ, liver, egg yolk and nuts. Green leafy vegetables are high in it but most are high oxalate especially spinach so must be cooked to break down the oxalates. I have posted on supplements so I will not get into detail but will list the most effective ones here.

http://healthyeating.sfgate.com/foods-high-alphatocopherol-3483.html

https://www.healthline.com/nutrition/foods-high-in-vitamin-e#section1

Nicotinamide reduces oxidative stress from endotoxins.

https://www.ncbi.nlm.nih.gov/pubmed/29803807

Foods that help increase nicotinamide are milk , yeast , mushrooms,fish, green vegetables and beer. Most beer is GMO it must be organic because the harm GMOs do would defeat the purpose.

https://www.superfoodly.com/nicotinamide-riboside-food-sources/

https://greatperformersacademy.com/health/7-foods-that-will-naturally-increase-nad-and-restore-your-youth

Lycopene reduces oxidative stress. Foods high in lycopene are tomatoes, watermelon, guava, papaya, sweet red peppers, purple cabbage, and mango. Some foods like tomatoes when cooked increases the amount of lycopene the body absorbs.

https://www.ncbi.nlm.nih.gov/pubmed/29454265

https://www.myfooddata.com/articles/high-lycopene-foods.php

https://draxe.com/lycopene/

Carbon dioxide reduces LPS damage but increasing it has to be done with caution. You can increase carbon dioxide by breathing into a paper bag for a short period of them. I would not do this for long though. It takes a while for oxygen levels to return to normal. I do not recommend trying this I put it here for others to research farther. Those with COPD, asthma, or lung damage would not fair well doing this.

https://www.ncbi.nlm.nih.gov/pubmed/29907213

https://chronicfatigue.livejournal.com/60641.html

http://smart-breathe.com/carbon-dioxide/

Because LPS increases estrogen because it prevents the body from detoxing it, it is important to decrease estrogen. Some medications increase estrogen, stress increases estrogen, nutrient deficiencies increase estrogen, environmental toxins can increase estrogen, emotional stress can increase estrogen. Many view estrogen as a female hormone, men can have high estrogen levels also. Oxidative stress caused by LPS causes nutrient deficiency which prevents the body from detoxing estrogen. It is very important to get the nutrients we need. Especially minerals and fats. Flouride, fluoroquinolones, farm chemicals especially glyphosate increase estrogen. It is best to eat organic when possible. Sunlight helps detox estrogen when we get it in moderation. Those who avoid getting sun have higher rates of cancer. Those who get too much sun have higher rates of kidney stones. So moderation is the key. There is not much research on reducing estrogen but when the other things are addressed and the detox enzymes are functioning again your body will detox the excess estrogen. Fiber also lowers estrogen. High estrogen levels cause lipid oxidation this can result in high triglyceride levels. High tryglycerides are a symptom and not a cause.

https://butternutrition.com/estrogen-dominance-hormonal-imbalance/

http://www.cheeseslave.com/balancing-hormones-naturally/

https://www.ncbi.nlm.nih.gov/pubmed/8039147

B vitamins are very important in detoxing estrogen. When taking folate do not confuse it with folic acid which is man made and has many negative effects on the body.

http://main.poliquingroup.com/ArticlesMultimedia/Articles/Article/801/10_Ways_To_Lower_Estrogen_Toxic_Load_.aspx

https://hormonesbalance.com/articles/b-vitamins-for-your-hormones/

https://testosteroneresource.com/tboosting-ingredients/vitamin-b6/

Inflammation

It is important to reduce inflammation. Inflammation can inhibit bile, inhibit the bodies ability to detox, it also can cause autoimmune disease. Bile detoxes many things in the body including LPS and it prevents it from entering the body through the digestive tract. If you get constipated or it feels like you have a brick in your stomach after eating then you may have inhibited bile production. This will cause you food to sit in the upper part of the digestive tract and it will ferment instead of digesting which causes many health problems. Cholesterol is needed to produce bile. If we have excess oxidative stress our cholesterol will get oxidize and it is another reason we must address oxidative stress and reduce it. Fats are also needed to produce bile, this also gets oxidized from oxidative stress. Also the metabolic issues like porphyria can cause problems with fat metabolism and is why it is very important to address metabolic issues. I have posted supplements that help with these issues. If you look through the list COX , inhibitors, anti-inflammatory nutrients will help to reduce inflammation. There are many things involved in the production of bile. Even our gut bacteria modulate bile production. Inhibited bile production can also cause problems with the gall bladder. Sulfation is also important factor in bile production so if you have high sulfite levels from gut dysbiosis, candida, CBS or BH4 issues then you need to address those also. Polyunsaturated fatty acids cause a decrease in the livers ability to detox estrogen.

Things that increase bile are lemon water, artichoke, dandelion root, foods high in sulfur. Taurine deficiency which is common in vegetarians can cause inhibited bile production. Taurine has been shown to increase bile flow.

https://www.belmarrahealth.com/bile-function-liver-foods-help-increase-bile-production/

https://www.ncbi.nlm.nih.gov/pubmed/3655556

Our gut bacteria also can cause inflammation if we are deficient in certain strains.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839080/

Bile

Bile aids in the absorption of healthy fat. If we have poor bile production it can have dramatic effects on the whole body. Every cell in the body needs fat, the brain is mostly fat so fat malabsorption effects the whole body.

https://empoweredsustenance.com/fat-malabsorption/

Many think their indigestion is from acid reflux but often times it is from inhibited bile production. Inhibited bile could cause a deficiency in fat soluble vitamins especially vitamin K. Antibiotics also reduce the gut bacteria that produces vitamin K which can add to the problem.

https://metabolichealing.com/bile-deficiency-heartburn-poor-digestion-toxicity/

This is a very in depth article on bile.

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1105662

Adrenal Fatigue

Endotoxins damage betadorphin nerves in the hypothalamus. This results in raised cortisol levels. This is another reason why it is very important to address inflammation. This results in insulin resistance and suppressed progesterone production. LPS causes high histamine levels , progesterone and testosterone are needed to protect us from histamines. There is supplements mentioned in my post on supplements that discusses ways to reduce histamines this is also cover in my post on how our gut bacteria effect our genes. We have histamine reducing bacteria. Adaptogenic herbs help with the adrenal fatigue caused by LPS.

http://www.mdpi.com/1422-0067/18/7/1431

Kupffer Cells

LPS stimulates liver kupffer cells which can cause a rise in reactive oxygen species and inflammatory cytokines. The body can get stuck in a cycle that escalates and the inflammation and oxidative stress will keep increasing. This is why it is very important to address oxidative stress, inflammation and work on detoxing LPS and excitotoxins so the cycle can be broken and healing can begin. If not broken this can result in liver fibrosis. Because kupffer cells are needed to detox LPS we do not want to inhibit them but we need to detox, and address metabolic issues and oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748178/

http://iai.asm.org/content/67/10/5409.full

Bradykinin

Bradykinin – it is a peptide that causes blood vessels to dilate, which decreases blood pressure. Bradykinan stimulates the release of Nitric Oxide, Postacyclin, Endothelium-derived hyperpolarizing factor. This allows the smooth muscle to relax , increasing their diameter which reduces blood pressure. Bradykinin raises internal calcium levels in neocortical astrocytes. Astrocytes fuel neurons with energy during times of stress , physical exertion, and periods of fasting. They are important in the flow of blood to the brain. Astrocytes clear excess postassium in extracellular space. Excess potassium can cause epilepsy. Astrocytes in the hippocampus suppress synaptic transmition by releasing ATP which through a number of processes produces adenosine. Adenosine prevents tachycardia. Astrocytes promote the healing of nerves but if over stimulated can cause nerve damage. Astrocytes can also promote nerve cell and brain cell growth. ACE inhibition raises bradykinin and causes the dry cough people get from taking ACE inhibitors. High bradykinin levels causes asthma, and swelling in legs , face, and abdomin. High bradykinin levels also causes vomiting and airway obstruction. Bromelain, aloe vera, and polyphenols reduce the effects of bardykinin.

HPA axis is important in the homeostasis of bradykinin.

https://www.ncbi.nlm.nih.gov/pubmed/?term=26468906

This is an description of bradykinin and the health effects.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658795/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518251/

bradykinin prevents blood clotting.

https://www.ncbi.nlm.nih.gov/pubmed/?term=26517864

Bradykinin can increase inflammation in our lungs during infections.

https://www.ncbi.nlm.nih.gov/pubmed/22935637

So we can see not enough bradykinin can effect our health as much as too much bradykinin. Homeostasis should be the goal with all our health goals. Once we reach homeostasis then we need to work towards maintaining it to prevent over doing things which can cause just as much harm.

http://www.nwpii.com/ajbms/papers/AJBMS_2011_2_09.pdf

High bradykinin levels can cause low blood pressure, tachycardia, blood vessel leakage, it can cause inflammation especially in the salivary glands. Bradykinin also raises substance P which causes burning in the scalp and down the spine, also can be felt in the skin and increases at night. ACE inhibitors raise bradykinin levels.

https://www.pharmacorama.com/en/Sections/Angiotensin_2.php

https://www.news-medical.net/health/ACE-Inhibitor-Side-Effects.aspx

Glycosides like astilbene and eurcrypin inhibit bradykinin. Also keep in mind histamines and inflammation stimulate bradykinin so we must reduce those also. Most plant polyphenols will reduce bradykinin especially grapes and the white part of citrus fruit. Also if we do not have high sulfite levels , high sulfur foods reduce bradykinin.

http://www.scielo.br/pdf/mioc/v86s2/vol86(fsup2)_182-189.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835915/

Hormones and their effects.

Adenosine- is involved in the regulation of blood pressure. If deficient a person could develop high blood pressure and tachycardia. It reduces inflammation by suppressing the activity of most immune cells. A deficiency can be caused by excess inflammation and immune responses. This can result in muscle fatigue. D-ribose has been found to help reduce the fatigue. So those with lung disease , cardiovascular disease or low immune function could be effected by adenosine.

Symptoms of adenosine deficiency would be muscle fatigue will exercising and frequent infections in the lungs. A deficiency in adenosine causes a loss of T regulatory cells. Symptoms of this are conditons such as eczema , and also type 1 diabetes. Adenosine deficiency also causes hypoxia. Excess adenosine can result in asthma. When cells are stressed or damaged adenosine increases. This is why I freqently say homeostasis should always be the goal. Those with low adenosine may have trouble sleeping.

https://www.sciencedirect.com/science/article/pii/S0167488916300842

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1276958/

Lactobacillus Reuteri helps reduce the symptoms from adenosine deficiency.

http://3dsbiovia.com/blog/index.php/2017/08/23/exploring-treatment-options-ipex-patients-gut-microbiome-insufficiencies/

http://jem.rupress.org/content/214/1/107

Excess adenosine and the complications from it. This is a caused by a deficiency in adenosine deanamase.

Causes Asthma and other lung inflammatory diseases.

https://www.ncbi.nlm.nih.gov/pubmed/26232643

https://www.ncbi.nlm.nih.gov/pubmed/12559769

Gotu Kola contains asiatic acid which helps with ada deficiencies.

https://www.ncbi.nlm.nih.gov/pubmed/29805609

Excess adenosine can cause prolonged painful penile erections which can result in damage to the penis.

https://www.fasebj.org/doi/abs/10.1096/fj.13-247833

Adenosine signaling is elevated in sickle cell anemia. Increasing Adenosine Deaminase would help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351509/

Hyeprthyroidism causes raised adenosine levels showing that we must protect the health of the thyroids.

https://www.ncbi.nlm.nih.gov/pubmed/7596349

Adenosine Deaminase breaks down adenosine. A deficiency causes many health problems because of raised adenosine levels. It can lead to skeletal issues, mental deficiencies, immune dysfunction, and hearing loss.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916829/

https://link.springer.com/article/10.1007%2Fs10875-018-0496-9

Curcumin inhibits ADA so should be avoided by those who have low ADA levels. There are nutrients that help support ADA production.

https://www.selfhacked.com/blog/about-adenosine-and-the-adenosine-deaminase-gene-rs73598374/

https://www.mygenefood.com/genes/ada/

Hypothyroidism causes reduce adenosine levels.

https://www.ncbi.nlm.nih.gov/pubmed/15811553

AdA levels can effect thyroid health.

http://www.thetrp.net/article.asp?issn=0973-0354;year=2015;volume=12;issue=3;spage=104;epage=106;aulast=Duwal

adenosine restores neutrophil chemotaxis endotoxins inhibit the bodies ability to locate infections. Adenosine restores this ability.

https://link.springer.com/article/10.1007/s00011-016-1021-3

Adiponectin

Adiponectin is a protein hormone involved in regulating glucose levels in the body. It plays a role in the endocrine system, and metabolic and inflammatory signaling. Issues with adiponectin have been tied to ADHD, diabetes, and arthritis. Those who have type 2 diabetes, obesity, hyperlipodemia, and arthritis have been shown to have low adiponectin levels. Those with low adiponectin have a higher risk of cardiovascular disease.

Adiponectin protects us from cardiac injury from endotoxins.

https://www.hindawi.com/journals/bmri/2014/382035/

http://www.jimmunol.org/content/182/10/6444

Adiponectin is produced in fat cells and muscle cells.

http://care.diabetesjournals.org/content/26/8/2442

https://www.ncbi.nlm.nih.gov/pubmed/24417944

EPA and DHA increase adiponectin.

https://www.ncbi.nlm.nih.gov/pubmed/25900100

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085721/

Palmitic acid increases the brown fat needed to produce adiponectin.

https://www.ncbi.nlm.nih.gov/pubmed/29654827

Chrysin found in high levels in flowers and honey increases brown fat.

https://www.ncbi.nlm.nih.gov/pubmed/27133810

Those with low adiponectin have a higher risk of cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pubmed/20096841

https://www.ncbi.nlm.nih.gov/pubmed/2905203

Phytic acid improves adipose differentiation improving the function of brown fat this improves insulin sensitivity. Phytic acid is found in grains and nuts. Eat food high in phytic acid in moderation it is an anti nutrient. Phytic acid also reduces sepsis.

https://www.ncbi.nlm.nih.gov/pubmed/25174657

https://www.ncbi.nlm.nih.gov/pubmed/17412285

The importance of improved cell differentiation in our brown fat is that it regulates the homeostasis of many things within out bodies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864949/

So here is how to increase brown fat.

https://getloss.com/weight-loss/strategies/how-to-increase-adiponectin.html

https://www.wikihow.com/Increase-Adiponectin

Our diet influences our adiponectin levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4400715/

Alpha-Melanocyte Stimulating Hormone

Alpha-Melanocyte Stimulating Hormone- it is an endogenous hormone and neuropeptide. It is one of the proteins responsible for hair and skin pigmentation. It plays a role in our feeding behavior, energy homeostasis in the body and even our sexual activity. It protects from injury that results from restricted blood flow, it also protects from the injury that results when the blood flow is restored. When blood flow has been restricted and then is restored it results in oxidative stress and inflammation. It also has antimicrobial properties.

https://www.selfhacked.com/blog/alpha-msh-its-role-in-weight-control-autoimmunity-cirs-and-cfs/

https://www.moldillnessmadesimple.com/cirs-melanocyte-stimulating-hormone-msh/

https://www.hindawi.com/journals/bmri/2014/874610/

https://www.atsjournals.org/doi/full/10.1164/rccm.200303-372OC

It helps prevent sepsis.

https://academic.oup.com/endo/article/144/1/360/2501731

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698338/

Glucose stimulates a-msh production which helps regulate glucose homeostasis.

https://www.sciencedirect.com/science/article/pii/S2212877816301028

Excess oxidative stress depletes a-msh.

http://www.ijbs.com/v13p0391.htm

It also protects us from the Nrf2 inhibiting effects of UVB rays thus protecting us from oxidative stress.

https://academic.oup.com/endo/article/150/7/3197/2456152

Low a-msh results in increased appetite, inflammation, increased pain, difficulty sleeping, and dehydration which results in low blood pressure from the excessive water excretion. Vaccinations, heavy metals, fluoride,fluoroquinolone drugs, glyphosate and other farm chemicals damage the pineal gland which has effects on the levels of a-msh. We also have a higher risk for cancer when it is low.

http://www.yourhormones.info/hormones/melanocyte-stimulating-hormone/

https://www.globalhealingcenter.com/natural-health/everything-you-wanted-to-know-about-the-pineal-gland/

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008958

It improves the bodies ability to heal.

https://www.ncbi.nlm.nih.gov/pubmed/25431356

This is why it is very important to get sun light in moderation. Sun light controls homeostasis of many body functions and is a much needed nutrient. Yes I am calling it a nutrient. It is the best way to describe sun lights effects on the body.

https://www.ncbi.nlm.nih.gov/pubmed/29546369

I am not certain what the effects on those suffering from Addison’s disease would be but they produce it in excess. Excess a-msh can cause a loss of appetite even cause nausea and vomiting, weakness, hypotenion and liver fibrosis.

https://www.ncbi.nlm.nih.gov/pubmed/2855222

Brain Nutriuretic Peptide

Brain Nutriuretic Peptide – is a hormone secreted in heart muscle cells. It reduces blood pressure, it reduces renal sodium reabsorption and increases the break down of fats. It reduces the release of aldosterone in the adrenal cortex. Aldosterone causes a reabsorption of salt and water into the body and a loss of potassium which results in high blood pressure. Those with Addison’s disease and chronic fatigue syndrome were found to have the opposite problem they have too much BNP in their bodies.

http://www.yourhormones.info/hormones/aldosterone/

https://openheart.bmj.com/content/4/2/e000697

BNP is released during strokes to protect the brain from injury.

http://jaha.ahajournals.org/content/6/12/e007329

Oldly enough high BNP levels increases the risk of high blood pressure in men but not women. It is released when the arteries start hardening, most likely to try and protect the body. Most know by now hardening of the arteries is caused by oxidative stress and inflammation. So high BNP levels would indicate a problem that needs addressed. I do need to research this more because I could not find much information on decreasing or increasing BNP safely.

http://hyper.ahajournals.org/content/hypertensionaha/41/4/978.full.pdf

https://academic.oup.com/cardiovascres/article/51/3/489/369493

Those who are deficient in BNP are more succeptable to fibrosis and lung disease.

https://www.ncbi.nlm.nih.gov/pubmed/16415273

https://www.spandidos-publications.com/10.3892/mmr.2016.5400

BNP is also a contributing factor to the myocarditis caused by endotoxins.

https://ccforum.biomedcentral.com/articles/10.1186/cc2890

Studies have shown that issues in the renal system can effect BNP levels. Most issues with the renal system are caused by toxins or infections, sometimes a lack of certain microbiotia in the gut.

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1527-5299.2007.06478.x

http://jasn.asnjournals.org/content/23/7/1198.full

BNP increases cortisol and catecholamine levels. There are adaptogenic herbs that reduce cortisol but not sure if they would help with this.

https://www.physiology.org/doi/pdf/10.1152/japplphysiol.00360.2016

Things that reduce BNP also reduces cortisol so I would say there is a feedback loop between the two and reducing cortisol would reduce BNP and vice versa.

Things that raise BNP are excessive alcohol consumption, smoking, stress, sleep deprivation, NSAIDs, oxidative stress, inflammation. So reducing oxidative stress, meditate and do other things to reduce stress, get plenty of sleep, stop smoking if you smoke, consume alcohol in moderation, use natural methods of reducing inflammation instead of NSAIDs shoulld reduce BNP and cortisol.

Calcitonin Gene Related Peptide

Calcitonin Gene Related Peptide is another mechanism the body uses to protect itself. It is released during pain or other stimuli that can indicate harm to the body. Is is found in the nerves throughout the body. It is released during inflammation in nerves and from activation of the capsaicin receptors in the gastrointestinal system. It is a vasodilator so can reduce blood pressure and prevent cardiovascular disease. If too high in the body it can cause high systolic blood pressure. It also causes head aches if levels are too high. Raise levels cause the nerves to become sensitive. Serotonin reduces CGRP. Low estrogen causes a rise in CGRP and is why many experience headaches around the time of their menstruations. Things that contain phytoestrogens may help with this.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620010/

https://www.sciencedirect.com/science/article/pii/B9780128010280001719

I do not recommend trying to increase CGRP because substance P is usually high in those with endotoxemia and it increases the potency of substance P.

https://www.sciencedirect.com/science/article/pii/000689939290812N

It inhibits the inflammation caused by endotoxins.

https://www.ncbi.nlm.nih.gov/pubmed/16317392

CGRP helps protect the lungs from injury.

https://www.ncbi.nlm.nih.gov/pubmed/28560441

https://www.ncbi.nlm.nih.gov/pubmed/12749828

https://www.ncbi.nlm.nih.gov/pubmed/28413467

It may be involved in bone repair.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jor.20406

If levels are too high there are natural inhibitors. Proanthocyanidins increases serrotonin which reduces CGRP. Avoid capsaicin it is a CGRP activator.

http://www.simplywellmigrainerelief.com/2017/02/03/cgrp-antagonistic-plants-natural-migraine-relief/

Mast Cells

Mast cells are one of the bodies first responses to an invader even in parasite invasions. They accomplish this through extracellular trap formation. They also release antimicrobial agents. Some pathogens like tuberculosis have developed strategies to avoid destruction by mast cells. Lyme is another infection that has developed more strategies to evade the immune system the HIV.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643406/

https://www.ncbi.nlm.nih.gov/pubmed/25114115

https://www.ncbi.nlm.nih.gov/pubmed/29892297

http://www.pnas.org/content/115/16/E3788.long

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469150/

Under normal conditions mast cells will reduce inflammation

https://www.ncbi.nlm.nih.gov/pubmed/28471519

When endotoxin levels get high then mast cells start to break down which causes high histamine levels. This results in allergies and sensitivities.

https://www.ncbi.nlm.nih.gov/pubmed/22581748

Because some pathogens can evade the effects of mast cells in removing them it can set off mast cell activation syndrome or mastocytosis. Both disorders are very similar and difficult to tell appart.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112577/

Description of mastocytosis. Symptoms can be skin rashes or lesions, difficulty breathing, swelling under the skin or in the mucous membranes, diarrhea, low blood pressure, bloating, Inhibiting inflammation, cox, and reducing histamines helps resolve this. I have mentioned in the links at the beginning of this article things that help reduce histamines and on another post I did no gut microbiome I mention probiotics that will reduce histamines. The symptoms of Mastocytosis and mast cell activation syndrome are similar and how to resolve it are the same.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002427/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122143/

Because LPS causes leaky gut it can result in mast cell activation , which leads to food intolerance and allergies. This in turn can lead to many metabolic issues.

https://healinghistamine.com/leaky-gut-the-mast-cell-histamine-crohns-disease-connection/

https://chriskresser.com/could-your-histamine-intolerance-really-be-mast-cell-activation-disorder/

Proenkephalin and Kyotorphin

proenkephalin an kyotorphin are neuroactive dipeptides that plays a major role in pain regulation in the brain. They release met-enkephalin which has opioid like effects. Low levels of kyotorphin causes persistent pain. It also reduces inflammation similar to how steroids do.

Has effects of endotoxin induced inflammation similar to how steroids would.

https://pubs.acs.org/doi/10.1021/acschemneuro.7b00007

They are neuroprotective

https://www.ncbi.nlm.nih.gov/pubmed/28127286

Kyotorphin levels have been found to be low in those with alzheimers.

https://www.ncbi.nlm.nih.gov/pubmed/24198785

kyotorphin has antimicrobial properties.

https://www.sciencedirect.com/science/article/pii/S0006291X12005128?via%3Dihub

Oxygen deprivation stimulates the release of kyotorphin.

https://www.ncbi.nlm.nih.gov/pubmed/29635654

Met-enkephalin reduces symptoms of chronic inflammatory diseases.

https://www.ncbi.nlm.nih.gov/pubmed/29261263

https://www.ncbi.nlm.nih.gov/pubmed/28647454

hypothalamus-adrenal-axis regulates met-enkephalin so it is important to reduce inflammation, histamines, and toxins because they can have a negative impact on them. Vaccinations, farm chemicals, fluoride and drugs, especially fluoroquinolone have been shown to disrupt the HPA axis. Stress and lack of sleep also disrupt the HPA axis. Thiamin deficiency can have a negative impact on the HPA axis and glyphosate causes many nutrient deficiencies. Many of us are in very stressful situations we cannot get out of, we must learn to remain calm because it will effect the HPA access. I know it can be difficult but if we don’t win that battle we will lose the long term battle.

https://www.ingentaconnect.com/contentone/isez/fb/2017/00000065/00000004/art00004?crawler=true&mimetype=application/pdf

https://bengreenfieldfitness.com/article/brain-articles/how-to-fix-hpa-axis-dysfunction/

http://ndnr.com/anxietydepressionmental-health/optimizing-the-hpa-axis/

Those who are G6PD deficient or have certain metabolic issues would get ill from the foods that contain thiamine so they may have to supplement thiamine until they have corrected those issues.

https://draxe.com/thiamine-foods/

Melatonin

Melatonin – is one of the bodies most powerful antioxidants. It is produced in the pineal gland. It regulates our sleep wake cycles. It is a powerful anti-inflammatory. It also regulates our blood pressure. It can be found in our food. Foods that contain it are bananas, grapes, rice, grains, plums, olive oil, pineapple, and oranges. I do not believe in taking things orally because often times taking things orally can disrupt the bodies ability to produce the substance so I try my best to stimulate the production or find food sources. Inflammation disrupts the production of melatonin.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666183/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754670/

Those who are G6PD deficient or have certain metabolic issues would get ill from the foods that contain thiamine so they may have to supplement thiamine.

https://draxe.com/thiamine-foods/

Melatonin helps prevent endometriosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015458/

Over consumption of alcohol causes leaky gut, we know leaky gut raises endotoxin levels. This leads to a reduction in metatonin.

https://www.physiology.org/doi/abs/10.1152/ajpgi.00002.2015

We know inflammation, toxins , stress, and many other things cause oxidative stress which cause high hydrogen peroxide levels. Melatonin reduces oxidative stress. Hydrogen peroxide causes severe damage throughout the body including the blood brain barrier which makes the brain succeptable to injury and infection.

https://www.sciencedirect.com/science/article/pii/0891584995001013

Unnatural light especially blue light like what is emitted by computer and cell phone screens disrupts our ability to produce melatonin. Sunlight stimulates melatonin production. Many things have cause magnesium deficiency which is needed to produce melatonin. Over farming has depleted nutrients from the soil, glyphosate and glufonisate chelate minerals from the soil, they are chemicals used in modern day farming.

https://www.institutefornaturalhealing.com/2015/05/5-natural-ways-to-boost-melatonin-production/

http://www.naturallivingideas.com/boost-melatonin/

https://www.sepalika.com/living-well/benefits-of-melatonin/

There are many benefits to getting sunlight in moderation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290997/

Norepinephrine, also known as Noradrenaline.

Norepinephrine – it is an amino acid derivative that functions as a hormone and neurol transmitter. It is produced in the adrenal glands and an area of the brain stem that is responsible for our responses to stress and panic. It functions to mobilize the body to action. It rises when we wake and in the presence of danger or stress. It enhances memory retrieval . Too much norepinenphrine causes restlessness and anxiety. It increases heart rate and triggers the release of glucose. It increases blood flow to the muscles. It reduces blood flow to the gastrointestinal system and inhibits bladder voiding. So it can cause inhibited digestion and difficulty voiding the bladder when levels are high. Norepinephrine prevents low blood pressure. Low levels of norepinephrine have been tied to depression and ADHD. So we can see how we need to reach homeostasis with norepinephrine because it has dramatic effects throughout the body. Metabolic issues can prevent it from being produced or prevent it’s break down. So if we have high or low levels we must address metabolic issues especially phenylketonuria.

https://breakingmuscle.com/fitness/understanding-our-adrenal-system-norepinephrine

Norepinephrine helps protect from sepsis.

https://www.ncbi.nlm.nih.gov/pubmed/25277635

Low norepinephrine has been linked to depression, impaired thinking, physical weakness, chronic fatigue syndrome, and fibromaylgia. High norepinephrine has been linked to increased attention, increased awareness, anxiety, restlessness, paranoia, increased heart rate, hypertension, reduced sensitivity to pain, ADHD, depression and difficulty digesting foods and difficulty urinating. There are ways discussed in this article to reduce or raise levels. Though the effects it has is incorrect in this article. Many sites state these things but when I read the research the effects I mentioned above is what the research has shown. So they may be correct on how to lover or raise levels but many sites are incorrect on the effects of norepinephrine.

Tryptophan and tyrosine are used to produce norepinephrine. I used this when my myocarditis was at it’s worse and I had severe POTS.

http://www.a1b2c3.com/Neurotransmitters-Norepinephrine-001.html

https://universityhealthnews.com/daily/depression/surprising-research-challenges-our-understanding-of-norepinephrine-deficiency/

https://healthyliving.azcentral.com/natural-ways-improve-serotonin-norepinephrine-production-4930.html

Low norepinephrine increases risk of dying from sepsis.

https://journals.lww.com/ajnonline/Fulltext/2017/07000/Norepinephrine_Shortage_Led_to_Increased_Deaths.9.aspx

This is where those with interstitial cystitis would not benefit from this because of the effects it has on blocking the ability to void the bladder.

https://www.openanesthesia.org/norepinephrine_cv_effects/

Endotoxins cause BH4 to upregualte to protect the brain. This can result in high sulfite levels in the body which can cause problems.

https://www.sciencedirect.com/science/article/pii/S0006899318300660?via%3Dihub

Hawthorne leaves and fruit have many healing abilities and have been shown to help with endotoxemia.

https://www.nature.com/articles/aps20167

Reducing Cholesterol, LDL is a symptom not a cause.

Cholesterol Dysregulation/High LDL

This is not medical advice I am sharing what I have learned from me fellow suffers. I am posting this to give others some ideas of things they could research. If you are ill you should see a doctor. Make sure if you are using alternative methods of healing you inform your doctor. I believe before getting treated for any pathogen you should always do a detox protocol first because most damage from being ill is from the endotoxins and exotoxins produced by the pathogens especially when they are dying off. If you have high Low Density Lipid cholesterol levels (LDL) then you most likely have an auto immune disease brought on by Vaccine Injury, Lyme Disease, toxins in the environment, many pathogens can cause Cholesterol Dysregulation, GMOs are known to destroy our guts which causes autoimmune disease and cholesterol dysregulation. Also bad eating habits, to much sugar causes inflammation which can cause oxidative stress which will raise oxLDL levels. Processed foods are high in oxLDL. Cooking increases oxLDL levels in food. Eat raw when possible. Eating processed foods. LDL is oxidized Cholesterol. If you have a lot of oxidative stress , like working too much, stress in our environment, toxins. Many things can cause oxidative stress. This causes the cholesterol to be oxidized much quicker. Gut problems can also cause high LDL levels. If we are having problems with our digestive system then our bile production will decline.

Endothelial Cells help in bile production, if they are not healthy then our production of bile declines decreasing our ability to remove LDL from our bodies. There is also a layer called Tight Junction Protein layer if it is damaged particles can get into our blood stream causing a histamine response which can cause inflammation throughout the body which can result in many problems, autoimmune disease, interstitial cystitis the list goes on and on the inflammation can interfere with many metabolic functions which could cause a rise in LDL levels. It isn’t much how much cholesterol we take in but the type and our environment that affects our LDL levels. Liver and Bladder problems brought on by all the above can cause Cholesterol Dysregulation.

If the Nrf2 pathways become blocked it will cause high LDL levels. Especially if the Pentose Phosphate Pathway becomes hindered or blocked. Another thing that can cause Cholesterol Dysregulation and this one surprised me but is also affected by autoimmune disease so it shouldn’t have is the Lymph Nodes. If they are plugged or infected they cannot help keep the blood cleaned out.
Get plenty of good cholesterol from sources such as coconut oil or avocados. Cholesterol is an antioxidant. If oxLDL is high it is a sign of excess oxidative stress or inflammation and the body is trying to protect itself. High oxLDL is a symptom not the cause. Lowering cholesterol will effect the brain and muscles negatively because they cannot function without it and the brain can suffer permanent damage if it does not get enough cholesterol. When I get a chance I will add the supporting links for these statements. .

Now That We Know The Problem Let’s Try To Solve it. The first thing I would do is work on reducing inflammation and lowering histamines. If you do have gut problems that would be the place to start. Next I would work on the methylation pathways. I covered some of that in my note on detoxing. I covered the CBS pathway also in that note. If it is blocked you will have trouble getting the Nrf2 ( nuclear factor-erythroid 2-related factor 2) pathways opened up because anything that raises gluthione production with cause you to feel ill. Another problem is antioxidants will actually cause you cancer if you take them too often or if the Nrf2 pathways are blocked. Don’t over do it with antioxidants and make sure you work on getting your Nrf2 pathways opened. Now some things that help open the Nrf2 pathway can also stimulate it so you do not want to over do it. When you start feeling better back of a bit. It is a good idea to space your supplements out anyways. Some things that will open the Nrf2 pathways are Oleanic Acid found in Savory and Olive Oil. Taxifolin (dihydroquerciten) also helps open them, it is a super antioxidant and one of the few that doesn’t need the Nrf2 to function. It is like Querciten on steroid. Chaga Mushrooms have Super Oxide Dismutase which helps the body in many areas. It is the only source I know of that the SOD is readily absorbed by the body, all the other sources have a low absorption rate. Do not take too much, raising SOD too high can raise reactive oxygen species which would have the opposite effect.

Cruciferous vegetables are high in sulforapanes which help open and stimulate the Nrf2. Make sure you do not have sulfation issue which can be caused by vaccine inujury , toxins like mercury and glyphosate. This will raise your sulfite levels which will cause high ammonia levels and high reactive oxygen species which causes damage from the oxy radicals being produced.

If NADP (Nicotinamide Adenine Dinucleotide Phosphate gets too high then the Pentose Phosphate Pathway could be inhibited. Low doses of Niacin along with Zinc, Vitamin C(too much vitamin C can destroy red blood cells, also man made vitamin C cause oxalates), NAD+, Vitamin D3, Curcumin, Querciten, Resveratol, Another thing that happens is if your methylation pathways aren’t working right or you have and infection your ammonia and hydrogen peroxide levels can go up and it will cause Cholesterol to oxidize. You would think that taking an antioxidant would be the solution but as stated earlier make sure you detox and get your methylation pathways corrected or that can do more harm then good. Now if you worked on your gut and methylation pathways. Then I believe we should work on the liver next. From my research I am lead to believe that oils high in monosatuarated fats produce less LDL when they are subject to heat. Some oil that are supposed to be good for cooking with high heat are. Hazel Nut Oil, Macadamia Nut Oil, Peanut Oil, Safflower Oil, Sesame Seed Oil, and Rice Bran Oil. Sun Flower is supposed to be one of the best but it scares me because Sunflower is used to pull toxins out of the soil. Canola is supposed to be good but most canola is GMO now. We need to be careful getting too many Omega-6, studies have shown if levels get too high we can develop mental issues even become violent, they can cause endothelial dysfunction which can cause high LDL levels, and cause inflammation.

So now if you worked on the above mentioned problems we are ready to move on to other issues we may have. Avoid Trans-Fats, unsaturated and saturated fats are bad fats and cause oxLDLs to go up. Reduce intake of Corn, Wheat, and processed sugar. They cause inflammation which for various reasons can cause oxLDL levels to go up. Termina Chebula – has many nutrients that help with methylation. Has many antioxidants, has also been shown to fight gum disease. Tyrosine – if you are not methylating properly your body cannot produce it. It is used by your body to build neuro transmitters and various proteins. Good sources are nuts, avocados, bananas, dairy products, beans and seeds. Ginkgo Biloba – improves the bodies use of oxygen but use in moderation, if used too long or in high doses it can damage the liver. Ginkgo Biloba with Raynaulds sysndrome and depression. P5P methylcolbamin molybdenum and manganese 3 times a week.  Those should help get the body methylating. When the methylation pathways open the body will start detoxing so you should continue the detox protocols the whole time. This could cause the bladder to become irritated again until the toxin levels are down. Those with certain methylation issues need to research before taking those.

The liver Of course drink good clean Chlorine free water. Chlorine is very toxic to the body and very difficult to remove from the body. Do not use flouride it is pretty much the same thing., If you are having problems with ammonia levels still I would suggest taking bromelain and betaine. Also Bacopa is supposed to helps. Papain is supposed to reduce symptoms of fatty liver. Omega-3 oils also help reduce fatty liver symptoms, I alternate the types of Omega 3s I use because each has it’s own benefits. Inositol Hexaphospate (IP6) is supposed to help clean the renal system out. Rosmarinic Acid, Ginger, Ashwangha, and Boswellia are all supposed to help with lipid peroxidation using these for too long or too much can have side effects. If the Nrf2 pathway is working antioxidants like Pycgenol, Lycopene, Allicin etc help lower lipid peroxidation.

CoQ10 is involved in the processes for producing energy for the cells. I use Ubiuinol it is the unoxidized form of CoQ10. Some things that can improve bile flow are Artichoke , Danshen, Prenylated Chalcone, Yarrow Root, Fennel Seed, Dandelion, Trolox, and Carom Seed have been shown to stimulate bile flow. Hesperetin has been shown to be powerful against lipid peroxidation. Aegle Marmelos is know to inhibit lipid peroxidation. Pinelba has been shown to protect the gut and inhibit lipid peroxidation. Silicon Dioxide, Magnesium, Iron, all help to produce bile, they need glycine and taurine to be bile.

Astanxanthin is another potent antioxidant. It reduces peroxide levels, and can cross the blood brain barrier to reduce swelling and provide the brain with energy. Catalase and Chloine also help to reduce lipid peroxidation. If you are low in choline you may get indigestion after consuming any fats. Golden Rod, Japanese Honeysuckle (most other honeysuckles are toxic) have been known to help clean the renal system out.

Lymph Nodes There are many things that can cause the lymph nodes to become plug. Not enough exercise , bad eating habits, environmental toxins, stress, not enough sleep, pathogens. Mold infections are another culprit. Vaccine and GMO damage the list could go on and on. If you read my not on detoxing then you should be half way to getting the Lymph Nodes cleaned out. There are special exercises and massage techniques that can be used to help clear the lymph nodes out. Also brushing the skin to ex-foliate also helps to clean the lymph glans out. Herbs That May help and Supplements for the Renal System.

Vitamin A -allows for proper gene activation within the lymph glands which helps the body develop proper immunity. Sources are orange colored fruits and vegetables, Kale and fish

L-Carnitine – required to transport fatty acids to mitochondria, protects and heals nerves. Protects and heals nerves. Found in meat and milk products, also found in asparagus. Also helps remove toxic compounds generated in cells.

Threonine – Helps prevent fatty liver, helps maintain proper protein balance in the body. Helps break down fats. Most vegetarians are low in this.

Pectin – shown to break biofilms, lowers bad cholesterol levels. Avena (Oat Straw) Helps balance our electrolytes. Has many nutrients needed for healing and proper functioning of the lymphatic system, helps improve cardiovascular health. Also has relaxant qualities. Most say it doesn’t affect them but it knocks me out.

Joe Pye – has been shown to fight renal infection. Should not be taken for extended periods of time because it is a sodium channel blocker.

Buchu – (Agathosma Betulina) fights urinary tract infections reduces hangover symptoms.

Silver Weed (Potentilla Anserina) The leaves have antiviral properties, and contains more flavonoids then green tea.

Aerva Lanata – has diuretic, anti-inflammatory, antispasmodic, antiparasitic, antimicrobial, hepa-protective and anti-asthmotic properties.

Eupatorium Perfoliatum – also known as Boneset (should not be taken for too long has alkaloids that can build up in the body) and Feverfew has been shown to be affective against the common cold and the flu. Aslo affective at treating cytokine dysregulation. Has been shown to be very affective against the plasmodian parasite.

mullein (Verbascum Thapsus) has antibacterial and expectorant properties. Has also been shown to fight mycobacteria. Is a natural anti-inflammatory. Helps ease menstrual and stomach cramps. Has been shown to help with interstitial cystitis.

Ajuga Decumbens improves liver and kidney function, helps correct hypoglycemia.

Hovenia Dulcis – protects the renal system, reduces oxidative stress. Helps to protect the brain. RDA 1400 to 2500 mg. Cysteamine – helps remove blockages in the renal system.

Acanthus Ilicifolius – increases production of osteoblast which are necessary for bone growth and health. Has been shown to help gastric ulcers heal. Has strong antibacterial and antifungal properties. Chlorophyll – helps restore blood health, lowers our risk of cancer, helps to remove heavy metals from the body and other toxins. Has been shown to fight Candida and protect the good bacteria in the gut. Sources are green produce, spirullina. Many including me had reactions to spirulina so I use liquid chlorophyll (to not use more then 3 times a week it can raise copper levels).

Horse Gram (Dilichos Biflorus) Help dissolve kidney stones, also kills many pathogens. The seeds are used to make tincture.

Varuma – Bark, root and leaves are used. Good at breaking up kidney stones, also hinders their formation. Has anti-inflammatory affects. The root is a laxative. Varuma also helps with flatulence and gas pains. !!May cause blistering if used on the skin!!

Oregano Oil – contains Carvacrol which protects the liver, has been shown to inhibit cancer growth. Works as a good nontoxic disinfectant. Has been shown to be as affective as chlorine. It kills Candida and helps protect the cardiovascular system from LDL and reduces inflammation.

Moringa Oleifera – has antibacterial properties. Has been shown to stabilize blood pressure. Helps reverse some liver damage. Contains Quercetin. The seeds have been shown to improve asthma symptoms.

Ajuga Decumbens improves liver and kidney function, helps correct hypoglycemia.
Cleavers helps clean the lymphatic system out.
Lemmongrass – Lowers oxLDL, helps get toxins out of the body and lowers uric acid levels. Has been shown to be affective against cancer. The essential oil has antimicrobial properties and has been shown to be affective against H-Pylori. Has also been shown to aid colitis. Calms muscles and nerves Helps relive pain including headaches. Has been shown to reduce the occurrence of convulsions and helps repair the immune system.!!Be careful some have had an allergic reaction to this.!!

Butyrate producing gut bacteria help reduce oxidize lipid levels.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0117851

Copper deficiency can cause oxLDL

https://wholehealthsource.blogspot.com/2010/04/copper-and-cardiovascular-disease.html

High Homocysteine can cause high LDL

https://www.sciencedirect.com/science/article/pii/S0014579309001860

Olive oil improves lipid metabolism.

https://www.ncbi.nlm.nih.gov/pubmed/12358487

Lipid peroxidation and HDL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656652/

Pantethine reduce oxLDL.

http://www.ppt-health.com/artery-plaque/pantethine-and-arterial-plaque-removal/

https://universityhealthnews.com/daily/heart-health/5-powerful-pantethine-benefits/

FXR is involved in cholesterol metabolism and it’s function becomes diminished with age.

https://www.journal-of-hepatology.eu/article/S0168-8278(13)00867-2/fulltext

High TMAO levels cause heart disease. I posted on how to reduce TMAO in my gut bacteria post.

Vitamin B6 deficiency can lead to heart disease.

https://www.sciencedirect.com/science/article/pii/S0899900706003224

https://academic.oup.com/ajcn/article/81/3/725/4649116

https://paulaowens.com/vitamin-b6-deficiency/

Causes of B12 issues.

https://www.b12-vitamin.com/blood-levels/

Calcium-D-glucuronidase reduces risk of cancer.

https://www.tandfonline.com/doi/abs/10.3109/09537104.2010.512210?journalCode=iplt20

https://www.hindawi.com/journals/ecam/2015/871832/

Alpha R-lipoic Acid helps with oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976966/

Liver disease and Pemt issues can cause oxLDL. I posted on fatty liver disease.

Hormones and cholesterol.

Cholesterols function in bile secretion. Issues with the liver X receptor can cause issues with cholesterol metabolism.

http://www.jbc.org/content/278/18/15565.long

https://www.ncbi.nlm.nih.gov/pubmed/29523554

Olive Oil help resolve liver X receptor issues. But inhibits glucuronidation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521785/

Butyrate found in butter and ghee also help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111843/

High estrogen inhibits sulfation. Increasing UDP-glucuronosyltransferases will reduce estrogen levels.

http://www.jbc.org/content/275/46/36164.full.pdf

http://dmd.aspetjournals.org/content/30/5/564

DHA, oleic acid, and linoleic acid inhibit those enzymes.

https://www.nature.com/articles/srep02903

Curly Dock and Yellow Dock

 

Yellow dockRumex Crispus

This is not medical advice and should not be taken as such. I have posted this for informational and educational purposes. Know your plants if in doubt don’t . Some parts of plants are edible while other parts can be lethal.

There are many species of yellow dock but the one most are familiar with is R. Obtusifolius. It has many benefits from detoxing, providing much needed nutrients especially minerals. The young shouts and leaves can be eaten but become high oxalate when they get older especially when the stems start turning red. Oxalates can cause severe damage in the body and even death. It is why I mainly use the root and only eat the stems once in a while when they are very young. Young first years roots taste good cooked in butter they have kind of a nutty flavor. When they get older they get tough and bitter. I use second year roots to make tea. So separate the seeds from the husk and use them to make flour. I have not been successful with that. I did see a video on Youtube were a young man used a food processor with a dough mixing blade on it to separate them and then put them on a tray an place a fan by them to blow the husk away and it seemed to work pretty well. The health benefits of the root is pretty astounding to me. There are other types of dock with similar benefits but in my area Yellow Dock is the most common. Most Docks have cross bread and share the similar benefits. R. Obtusifolius or very common and have cross bread so much you can barely tell them apart.

https://www.ediblewildfood.com/yellow-dock.aspx

https://www.mommypotamus.com/yellow-dock-root-benefits-uses/

The leaves are so high in oxalates eating them can be fatal.

https://www.ncbi.nlm.nih.gov/pubmed/2238449

The seeds have antifungal properties.

http://jjmicrobiol.com/en/articles/13733.html

It is a good source of antioxidants.

http://www.sciencedomain.org/abstract/16950

Helps with just about every illness it is even good for detoxing.

https://www.ncbi.nlm.nih.gov/pubmed/26384001

Since most Yellow Dock has cross bread with Curly Dock I am going to include studies on it.

Has renal protective effects.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424563/

https://www.sciencedirect.com/science/article/pii/S0960894X13005404?via%3Dihub

Contains nepodin which helps with diabetes

https://www.ncbi.nlm.nih.gov/pubmed/24756979

Nepodin malaria

https://link.springer.com/article/10.1007%2Fs12272-013-0055-0

Protects DNA and fights cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506869/

The fruit protects from oxidative stress.

https://www.ncbi.nlm.nih.gov/pubmed/20623623

The root prevents bone loss so would help with osteoporosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657118/

Yarrow

 

 

 

Achillea Millefolium

This is for educational and informational purposes and should not be taken as medical advice. If in doubt don’t. If you do not know a plant well do not use it.

I do not like the taste of Yarrow but I do know eating it has had noticeable effects. I noticed I had increased energy levels. There are sites that claim it lowers blood pressure but my friends who had hypertension experienced a rise in their blood pressure when they used Yarrow. Has has been used for many illnesses even hemorrhoids. There are claims that when applied to wounds it stops bleeding. There are many species of Achillea but I am fimiliar with A. Millefolium. The others  chemical makeup is very similar.

https://www.ediblewildfood.com/common-yarrow.aspx

https://wellnessmama.com/7106/yarrow-herb-profile/

It’s effects on cancer.

https://www.ncbi.nlm.nih.gov/pubmed/29883784

Speeds up healing.

https://www.ncbi.nlm.nih.gov/pubmed/29731432

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610620/

Contains Achillolide A which prevents amyloid plaque build up and would help with Alzheimer. Achillolide A has many benefits.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960475/

Achillolide A reduces reactive oxygen species.

https://www.researchgate.net/publication/296602862_Achillolide_A_Protects_Astrocytes_against_Oxidative_Stress_by_Reducing_Intracellular_Reactive_Oxygen_Species_and_Interfering_with_Cell_Signaling

Yarrow helps with diabetes by increasing insulin sensitivity.

https://www.ncbi.nlm.nih.gov/pubmed/29031783

Reduces anxiety

https://www.sciencedirect.com/science/article/pii/S0378874111008567?via%3Dihub

They claim it reduces blood pressure through it’s diuretic properties but I have seen it increase peoples blood pressure. One thing I did notice the ones it increased blood pressure in did not drink adequate amount of water.

https://www.ncbi.nlm.nih.gov/pubmed/23791807

Improves cognitive abilities, prevents strokes, reduces oxidative stress, reduces symptoms of MS, and helps with neurodegenerative disorders.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569446/

Phytochemicals

https://www.ncbi.nlm.nih.gov/pubmed/15688780

http://www.actabp.pl/pdf/2_2011/203.pdf

has antimicrobial properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590066/

Only way to describe this is it enhances the immune system.

https://www.ncbi.nlm.nih.gov/pubmed/27083352

Reduces pain

https://www.ncbi.nlm.nih.gov/pubmed/26238568

Appears to kill pain without no toxicity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686861/

Can cause problems in those with high glutathione levels. This study is viewed as negative but it appears by their results it reduce quinone and would help with interstitial cystitis. If I had time I would get into more detail and explain why.

https://www.ncbi.nlm.nih.gov/pubmed/25870009

Helps with diabetes by protecting pancreatic cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293613/

Reduces oxalates so would help with high oxalate levels and stone formation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290053/

It is effective against the New Castle Disease Virus and other infections.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138681/

https://www.ncbi.nlm.nih.gov/pubmed/12860311

Is neuroprotective, protects the brain.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071708/

Has antispasmodic effects.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847392/

Inhibits histamine H1 receptors and muscarinic receptor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831720/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608287/

This is what I notice in the other study and why I said it would help with interstitial cystitis. It has NO scavenging abilities. The also would help with kidney disease were people have excessive bleeding.

https://www.ncbi.nlm.nih.gov/pubmed/22976260

How it helps with acid reflux or gastric irritation.

https://www.ncbi.nlm.nih.gov/pubmed/22151891

https://www.ncbi.nlm.nih.gov/pubmed/20420892

https://www.ncbi.nlm.nih.gov/pubmed/19093480

How it helps with asthma and hypertension

https://www.ncbi.nlm.nih.gov/pubmed/20857434

Is a calcium channel blocker. This would help with things like high blood pressure, and other circulatory disorders.

https://www.ncbi.nlm.nih.gov/pubmed/16619341

Yarrow stimulates bile production so would help with constipation and gall bladder issues.

https://www.ncbi.nlm.nih.gov/pubmed/16303291

Velvet Leaf Plant

Abutilon Theophrasti

This is not medical advice I am posting this for information and educational purposes and should not be taken as medical advice. If in doubt don’t make certain of a plant before you use it.

I have eaten the seeds but no other parts. This plant is new to me. I know it is Roundup ready because I have seen it in field that had been sprayed by Glyphosate containing products so be careful where you forage it. They can overtake a crop and can reduce production. The fiber is used to make rope. I have seen sites that claimed the seeds can remain viable in the soil for many many years. So when I forage them for the seeds I pull the whole plant out because I get them from a friend who grows his crops organically and uses no harmful chemicals.

http://www.eattheweeds.com/velvet-leaf-fiber-and-food/

https://gobotany.newenglandwild.org/species/abutilon/theophrasti/

The leaves have antioxidant, antibacterial and anti-inflammatory properties. The leaves also reduce hydroxy radicals.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872602/

http://www.ptfarm.pl/pub/File/Acta_Poloniae/2017/3/881.pdf

Contain Hibiscuslide C which is antifungal.

https://www.ncbi.nlm.nih.gov/pubmed/23816874

The flowers are high in flavoniods.

https://www.ncbi.nlm.nih.gov/pubmed/16161355

Sumac, no it is not poisonous.

Rhus Typhina

This is not medical advice and should not be taken as such. If you are not certain don’t, do not use a plant if you do not know it. Make certain of thing you plan on eating or using.

No it is not poisonous. It is very tasty it taste like lemon aid but does not have the bitter after taste. It has many health benefits. The poison sumac is not in the same family. There are many in the Rhus family which is the sumac family. The one I will be talking about is Rhus Typhina which is known as Staghorn Sumac. There are a few other species in my area but Staghorn Sumac has the lowest oxalate levels. The sumac berry of all species is very high in nutrients. It grows very quickly and spreads through the roots or seeds so be careful where you plant it. Since the nutrient content of most of the rhus are the same I will list studies for a variety from the rhus family and it would most likely apply to R. Typhina.

http://www.valuefood.info/61/health-benefits-of-sumac/

Many cultures have used Sumac berries in their cooking and there are many recipes on the internet on using them in your cooking.

https://www.easylebaneserecipes.com/sumac-health-benefits-in-your-food/

Phytochemicals.

https://www.ncbi.nlm.nih.gov/pubmed/23850248

Helps prevent Parkinson’s Disease.

https://www.ncbi.nlm.nih.gov/pubmed/28419945

Helps break up biofilms.

https://www.spandidos-publications.com/mmr/16/1/949

Fights cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758048/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532997/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599689/

High in gallic acid which protects our DNA.

https://www.ncbi.nlm.nih.gov/pubmed/19022266

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731335/

Helps with diabetes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232791/

Lowers oxLDL levels

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269531/

https://www.ncbi.nlm.nih.gov/pubmed/29425477

Stimulates PON1 which helps with detoxing and diabetes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274568/

Neuroprotective

http://www.mdpi.com/2227-9059/6/2/48

Scavenges reactive oxygen species. Reduces oxidative stress. Which would relax the blood vessels and lower blood pressure.

https://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1185797

Self Heal

self heal

Prunella Vulgaris is the one I am familiar with Prunella Grandiflora has bigger flowers and I have never seen it. They are known as heallall, or self heal.

This is not medical advice this is form information and educational purposes and should not be taken as medical advice. If in doubt don’t, if you are not certain of the identification of a plant do not use it. Has many health benefits and has been shown to stimulate healing throughout the body including areas that are difficult to heal like cartilage and ligaments. Has been shown to fight cancer and infection.

https://www.ediblewildfood.com/self-heal.aspx

Fights cancer through multiple pathways.

https://www.ncbi.nlm.nih.gov/pubmed/25331476

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865815/

https://www.ncbi.nlm.nih.gov/pubmed/27586473

https://www.spandidos-publications.com/or/34/5/2445

Protects against UVB damage and aging.

https://www.ncbi.nlm.nih.gov/pubmed/29378470

Prevents renal fibrosis so would help with fatty liver.

https://www.worldscientific.com/doi/abs/10.1142/S0192415X1750029X?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

Protects cognitive function.

https://www.ncbi.nlm.nih.gov/pubmed/28001065

https://www.ncbi.nlm.nih.gov/pubmed/26376910

Helps with diabetes.

https://www.ncbi.nlm.nih.gov/pubmed/27768926

https://www.ncbi.nlm.nih.gov/pubmed/25278372

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471066/

Helps with autoimmunity,excess inflammation and allergies.

https://www.ncbi.nlm.nih.gov/pubmed/27566209

https://www.ncbi.nlm.nih.gov/pubmed/26996013

http://pubs.rsc.org/en/Content/ArticleLanding/2015/FO/C4FO01039F#!divAbstract

Helps fight Ebola.

https://www.ncbi.nlm.nih.gov/pubmed/26778707

Helps with leaky gut.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635162/

Helps with fatty liver.

https://www.thieme-connect.com/DOI/DOI?10.1055/s-0035-1558112

Is high in ursolic acid which has many health benefits.

https://www.ncbi.nlm.nih.gov/pubmed/25088993

https://www.truthinaging.com/ingredients/ursolic-acid

Phytochemistry

https://www.ncbi.nlm.nih.gov/pubmed/25078822

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206729/

https://www.ncbi.nlm.nih.gov/pubmed/21498022

Anti inflammatory

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856017/

Prevents heart disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789443/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133916/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782109/

Great for detoxing.

https://www.ncbi.nlm.nih.gov/pubmed/23477155

Helps with ADD

https://www.ncbi.nlm.nih.gov/pubmed/23348874

Reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269750/pdf/ijms-13-01258.pdf

https://www.jstage.jst.go.jp/article/bpb/31/3/31_3_531/_article

Inhibits HMGB1 which helps with sepsis.

https://www.ncbi.nlm.nih.gov/pubmed/21971692

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363608/

Inhibits HIV infection

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096947/

Inhibits virus replication

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645367/

https://www.ncbi.nlm.nih.gov/pubmed/17475343

https://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-951719

Helps with mast cell activation syndrome or allergies.

https://www.ncbi.nlm.nih.gov/pubmed/17609508

Skullcap

Scutellaria

This is not medical advice and should not be taken as such , I am posting this for information and educational purposes only. If in doubt don’t please know your plants before using them.

There are many plants that are poisonous that get mistaken for Scutellaria and are sometimes contaminants in supplements containing Skullcap. Two of the most common that can be mistaken for Skullcap that are poisonous are Downy Skullcap (scutellaria icana) and Germander which is in the Teucrium family.

The ones with the most health benefits in the order of effectiveness are Sculletaria Racemosa, Sculletaria Biacalensis, and the one with the best sedative effects is Sculletaria Lateriflore.

They contain biacalein which I have seen miss spelled as biacalin in some studies. It has amazing healing abilities. S Racemosa has the highest levels of biacelain. It has been shown to be very effective against cancer with little side effects. One of the problems I had with Skullcap was that it healed my nerves and improved my blood circulations so fast that all heck broke loose. The best way I can describe it is when you sleep on your arm and it goes to sleep. As the blood flow returns you experience muscle spasms and major tingling. That happened to me for about three days when I started taking it and then I started to feel much much better. I was surprised at how fast it was healing me. I used Sculletaria Racemosa.

https://draxe.com/skullcap/

http://www.herbslist.net/skullcap.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678518/

Biacalein has been shown to be effective against liver fibrosis and correct metabolic disorders.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678518/

Skullcap helps with asthma and COPD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971322/

It has antibacterial and anti inflammatory effects which helps prevent periodontal disease.

https://www.karger.com/Article/Abstract/92853

Effective against various types of cancer.

https://www.spandidos-publications.com/10.3892/mmr.2018.9036

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929448/

https://www.ncbi.nlm.nih.gov/pubmed/29797601

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688794/

https://www.worldscientific.com/doi/abs/10.1142/S0192415X18500027?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

This would also help interstitial cystitis because this is something cancer patients and those with interstitial cystitis have in common.

https://www.ncbi.nlm.nih.gov/pubmed/29697746

Reduces artherosclerosis by reducing oxidative stress.

https://www.ncbi.nlm.nih.gov/pubmed/29793330

https://www.ncbi.nlm.nih.gov/pubmed/29495284

Reduces inflammation and the way it does it would be very beneficial for those with interstitial cystitis.

https://www.ncbi.nlm.nih.gov/pubmed/29331857

Reduces hypertension

https://www.worldscientific.com/doi/abs/10.1142/S0192415X18500404?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543745/

Improves chances of having a successful pregnancy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963314/

Helps with autoimmune disorders.

https://www.ncbi.nlm.nih.gov/pubmed/29656117

Protects the brain and nerves and stimulates healing.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758355/

https://www.ncbi.nlm.nih.gov/pubmed/21718777

https://www.jstage.jst.go.jp/article/bpb/41/4/41_b17-00768/_article

Helps with NAFLD, fatty liver disease.

https://www.ncbi.nlm.nih.gov/pubmed/29542003

https://www.ncbi.nlm.nih.gov/pubmed/29158052

https://www.ncbi.nlm.nih.gov/pubmed/29031535

Helps fight the flu.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869510/

http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl&product_id=5567&category_id=145&option=com_virtuemart&vmcchk=1&Itemid=1

Prevents heart failure.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783530/

https://www.ncbi.nlm.nih.gov/pubmed/29047162

https://www.spandidos-publications.com/mmr/16/6/9251

Reduces bone inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/29253124

Helps heal leaky gut.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707656/

Helps with diabetes.

https://www.ncbi.nlm.nih.gov/pubmed/29028535

The list goes on and on as to the benefits of Skullcap.

Knotgrass

Polygonum Aviculare

This is not medical advice it is for information and educational purposes. If in doubt don’t, please make sure you know your plants before using them.

Also known as knotgrass. Usually used to make tea. In Japan it is used in soups and crushed and used in many other dishes. It has oxy radical scavenging abilities.

http://www.ediblewildfood.com/knotgrass.aspx

https://medievaldigger.wordpress.com/2015/03/02/spring-is-coming-and-so-is-the-knotgrass-an-herbal-wound-cleanser/

It can scavenge peroxynitrate which cause a lot of damage in the body especially to the bladder and blood brain barrier. It reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pubmed/24270289

https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000200010&lng=en&nrm=iso&tlng=en

Prevents artherosclerosis.

https://www.ncbi.nlm.nih.gov/pubmed/24370878

Slows aging because it is high in Juglanin

https://www.ncbi.nlm.nih.gov/pubmed/24638927

https://www.ncbi.nlm.nih.gov/pubmed/24519811

Helps with asthma and COPD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814568/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881803/

High in Juglanin which inhibits cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706842/

https://www.ncbi.nlm.nih.gov/pubmed/27899257

Is neuroprotective.

https://www.ncbi.nlm.nih.gov/pubmed/29136779

Juglanin is hepaprotective.

https://www.ncbi.nlm.nih.gov/pubmed/27261609

https://www.ncbi.nlm.nih.gov/pubmed/21783944

Promotes healing.

https://www.ncbi.nlm.nih.gov/pubmed/26929003

Has antimicrobial properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730555/

Reduces fibrosis

https://www.ncbi.nlm.nih.gov/pubmed/10706393

Wild Violet

Viola

This is not medical advice and should not be taken as such. It is for information and educational purposes. If in doubt don’t make sure you know your plant before you use them.

Their are many species of wild violet but their nutrients and phytochemistry is pretty much the same.

Viola Biflora, Viola Canina, Viola, V. Labradorica, V. Odorata, V. Rostrata, and V. Sororia are the ones I am familiar with. They all taste the same to me. I love them it is one of my favorite wild edibles. I could eat wild violets daily. They have similar nutrients as dandelion only higher levels of them.

http://www.ediblewildfood.com/wild-violet.aspx

https://thesurvivalmom.com/enjoy-wild-violets/

The viola species have hepaprotective properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217637/

They reduce inflammation and an over active immune system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918579/

Reduces coughing

https://www.ncbi.nlm.nih.gov/pubmed/25954025

Phytochemicals that are good for the heart and oxidative stress.

https://www.ncbi.nlm.nih.gov/pubmed/23035206

Reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967839/

https://www.ncbi.nlm.nih.gov/pubmed/26751970

Is nueroprotective.

https://www.ncbi.nlm.nih.gov/pubmed/27516984

Anti inflammatory.

https://www.ncbi.nlm.nih.gov/pubmed/17983197

Fights cancer

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163403/

Fight bacterial infections.

https://www.ncbi.nlm.nih.gov/pubmed/20558471

Reduces histamines

http://www.thepab.org/files/2017/March-2017/PAB-MS-160199.pdf

https://www.sciencedirect.com/science/article/pii/S0378874113005941

Is high in mucilage which heals the gut. It is so high that when I make tinctures they come out like a gel.

https://thenaturopathicherbalist.com/herbs/v-z/viola-tricolor/

Ironweed, Veronia species of flowers.

Veronia Noveboracensis known as New York Ironweed is the one I am familiar with. Most of the Veronia species contain Vernolid A which has been shown to inhibit cincer. V Noveboracensis does not contain as much as the others. This is the only species I have seen in person.

https://www.ncbi.nlm.nih.gov/pubmed/21256125

https://www.ncbi.nlm.nih.gov/pubmed/22176676

https://www.ncbi.nlm.nih.gov/pubmed/21649480

Veronia Amygdalina and V. Cinerea were the most potent of the Veronia species.

https://www.ncbi.nlm.nih.gov/pubmed/23395623

V Amygdalina reduces oxidative stress and helps with diabetes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295350/

V Cinerea can help with nicotine addiction.

https://www.ncbi.nlm.nih.gov/pubmed/25857233

V Amygdalina can reduce oxidative stress.

https://www.ncbi.nlm.nih.gov/pubmed/26196573

V amydalina is hepaprotective.

https://www.ncbi.nlm.nih.gov/pubmed/25553678

Have not seen toxicity studies on the other Veronia species but V. Cinerea shows no toxicity.

https://www.ncbi.nlm.nih.gov/pubmed/20645763

Lemon Balm

Melissa Officinalis

This is not medical advice and should not be taken as such. If in doubt don’t if you do not know a plant do not use it.

Lemon Balm is good for soothing the stomach and for relaxing. It has also been shown to be good for making a balm for herpes chancres. Improves blood sugar levels, also helps with getting restful sleep. Has been shown to protect the brain cells.

https://thenerdyfarmwife.com/12-things-to-do-with-lemon-balm/

https://www.globalhealingcenter.com/natural-health/9-benefits-of-lemon-balm/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230760/

Helps fight viruses even herpes.

https://www.ncbi.nlm.nih.gov/pubmed/24817544

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613005/

Safe to consume in large quantities.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433273/

Is good at treating and preventing oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871149/

It helps with ventricular arrhythmia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586902/

Has been shown to help with heart palpitations.

https://www.sciencedirect.com/science/article/pii/S0378874115000781?via%3Dihub

Has antimicrobial properties.

https://www.ncbi.nlm.nih.gov/pubmed/20201279

https://www.ncbi.nlm.nih.gov/pubmed/26075899

The flavonoids found in Lemon Balm along with other herbs have antidepressant properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829422/

Fights cancer

http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:26320439&key=2015.16.14.5703

Phytochemicals

https://www.ncbi.nlm.nih.gov/pubmed/26495650

Reduces premenstrual symptoms.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4557408/

Improves cognitive function.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1738567/

Has been shown to reduce histamines.

http://opensiuc.lib.siu.edu/cgi/viewcontent.cgi?article=1342&context=ebl