Written by Lee Stevenson, sorry I am not the best editor.
This is not medical advice. I am posting this for educational purposes. Supplements should be taken with the guidance of a qualified and experienced naturopath.
High ammonia levels can be caused by infection, excess inflammation, emotional trauma or stress, eating foods high in glyphosate, metabolic issues , Alpha-ketoglutarate deficiency which can actually be caused by high ammonia levels so it creases a self feeding cycle. Also issue with sulfation pathways and BH4 pathways can cause high ammonia levels. These newer Covid injections are damaging the renal system making it difficult for the body to clear ammonia and other toxins from the body. Fluoroquinolones are a very very harmful antibiotic that severely damages the body causing high ammonia levels and it increases the microbes in the gut that produces ammonia. High ammonia levels increase the risk of heart failure by reducing the ATP needed for heart function, by increasing inflammation in the heart and by causing excess blood clotting. High ammonia levels will also cause mast cell degranulation which causes high histamine levels. Ammonia also cause neurological damage. So it may be necessary to reduce consumption of aged or fermented foods. High ammonia levels also damages the blood vessels in the body. High ammonia levels also causes high oxalate levels and causes leaky gut which increases oxalate absorption. So until ammonia levels are reduced the gut cannot heal.
High ammonia levels also causes thyroid issues. It will cause high T4 levels. It will also increase estrogen levels and alter the levels of other hormones in the body.
When ammonia levels are high it inhibits ATP production and also interferes with the production of hormones and proteins in the body. It also increases glutamate and glutamine levels which will cause the NMDA receptor to become over activated causing autism and many mental issues. High glutamate will cause very very severe headaches. The reduce ATP production can damage the heart and cause fatigue. Ammonia can also effect sulfation pathways which would cause another cycle that need broken because when they are inhibited sulfite levels can get high and cause increased ammonia levels in the body. High ammonia levels also damages the blood brain barrier which permits toxins and infectious agents to enter the brain that could not normally enter the brain adding to the swelling in the brain that is already occurring from the high ammonia levels. Most ammonia comes from the gut, from bacteria overgrowth usually induced by antibiotics or consuming processed foods especially GMO foods. High ammmonia levels also causes anemia and low oxygen levels. One sign that a person has high ammonia levels is ketone levels will be high in the urine from inhibited mitochondrial energy production.
Until the ammonia levels are down and the metabolic issues are addressed it may be necessary to get protein from plant sources because animal protein consumption increases ammonia levels in the body. The body needs some ammonia but it is very harmful when in excess. Excess ammonia can damage the urinary tract and cause liver disease, interstitial cystitis, and can alkalize the gut causing an overgrowth of Candida and H pylori. They produce ammmonia creating another cycle that would need broken. Reducing ammonia levels will help to reduce the Candida and H pylori. Carbohydrates are needed by the body a deficiency in carbohydrates causes autoimmunity and increases ammonia levels. High ammonia levels also interferes with the bodies ability to metabolize phenylalanine which causes another cycle that increases ammonia so foods high in phenylalanine will cause high ammonia levels until the cycle is broke by supplying the nutrients need to break the cycle. Salt deficiency can also cause high ammonia levels.
Water needs to be from a clean source. Most public water has chlorine which causes many health problems and they are contaminated with toxins. Well water is usually excessively high in iron and sulfur and has been shown to be the number one cause of Alzheimers and Parkinson’s disease.
The list of supplements is going to be extensive because it takes a lot to get things functioning properly to clear ammonia from the body. I will put a star by the once that specifically reduce ammonia but if a person does not correct the issues that caused the high ammonia they may not heal.
This is a list of supplements that can help to reduce ammonia levels in the body.
Cinnamon is very effective at reducing ammonia. It even reduces ammonia in the brain.
*wheat grass or barley grass
*L-carnosine which would also help reduce the inhibited oxidative phophorylation.
*Low dose biotin
*Low dose manganese
*Low dose molybdenum
*Ubiquinone a bioavailable form of COQ10
*P5P (pyridoxal 5-posphate
*Alternate between magnesium citrate and magnesium glycinate.
*L-theonine reduces ammonia and heals the gut.
Nitric oxide can be increased by eating leafy greens or beet root juice.
Grape seed extract
Vitamin C do not take super high doses it can cause oxalates and damage red blood cells.
B vitamins riboflavin, thiamine , B12 and folate. Folate should never be taken in the form of folic acid it is man made and toxic to the body. Leafy greens, bean, and legumes are high in folate.
Oil soluble vitamins E, D3 and vitamin K2. These should be taken with an Omega three oil which is best to alternate them. I alternated between coconut oil, olive oil and Cod liver oil.
Alpha lipoic acid
Low dose selenium
Low dose iodine
*Bacopa or Butchers broom can help with the cardiovascular damage.
*Betaine (trymethyglycine, TMG)
Probiotic and gut microbes that can help to reduce ammonia levels are:
Bifidobacterium will increase GABA. High ammonia levels causes low GABA levels.
Commensal E coli like E coli nissle 1917
Roseburia decreases ammonia levels
Overgrowth of these microbes can cause high ammonia levels:
The only way to find out the cause of gut high gut derived ammonia levels is by getting a GI map test done. Usually eating fruit that have lower sugar content like cherries and pomegranate will reduce the ammonia producing microbes.
Pathogenic E coli
Pathogenic streptococcus species
Also an overgrowth of microbes that produce hydrogen sulfide can increase ammonia levels in the body.