Symptoms of high oxalates are gout, arthritis, kidney stones which causes back pain, gut issues, brain fog, vulvadynia, painful urination, cloudy urine, depression, bladder pain, muscle weakness . Most issues with oxalates are not from the oxalates we consume but health issues that need addressed. I often time get upset when people ask how they can reduce oxalates. It is not a simple question, there are many causes of high oxalates and consumption of foods that contain them are not the main reason because almost all foods have oxalates. Make sure you avoid processed sugar and artificial sweeteners they cause oxalates. Most who have high oxalates also have sulfation issues. I have posted on sulfation. If you have sulfation issues and high oxalates you cannot detox.
https://drjockers.com/low-oxalate-diet/
http://www.lowoxalate.info/research.html
An exception to this is green smoothies. Many plants used in smoothies are high oxalate like kale and spinach they are very high oxalate.
https://www.ajkd.org/article/S0272-6386(17)30863-6/fulltext
https://veganhealth.org/oxalate/
glyoxylate metabolism and oxalates.
Oxidative stress can interfere with glyoxylate metablism causing high oxalates.
https://www.hindawi.com/journals/au/2012/819202/
http://jasn.asnjournals.org/content/29/6/1615.long
http://www.mdpi.com/1660-4601/14/1/109
Glyphosate a herbicide found in most of non organic foods effects glyoxylate metabolism causing oxalates. Many farm chemicals found in non organic foods cause oxalates by causing oxidative stress which effects fatty acid metabolism and glyoxylate metabolism
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(16)30474-3
https://pubs.acs.org/doi/abs/10.1021/acschembio.6b01001?source=cen
Now imagine you are having trouble with glyoxylate metabolism and you are consuming food high in glyphosate. It would not be good.
https://link.springer.com/article/10.1007%2Fs10545-017-0105-8
More in depth information on oxalates.
http://www.iksi.org/images/uploads/Origin_of_Urinary_Oxalate.pdf
Most oxalates that people have to worry about are endogenous. As for eating oxalates the only time they are a real issues is when we have gut issues. Either we have leaky gut or we are lacking the bacteria that break down oxalates. Cooking destroys oxalates and many of the high oxalate foods like kale and spinach are usually cooked. Most foods contain oxalates and often times the oxalate or being produced endogenously (produced internally) the exogenous oxalates are usually not the problem.
https://www.thepaleomom.com/oxalate-sensitivity-real/
https://scdlifestyle.com/2017/08/oxalates-and-gut-issues/
http://www.beyondmthfr.com/oxalates-and-mthfr-understanding-the-gut-kidney-axis/
Often times the high oxalates are caused by the body itself because of a lack of nutrients or metabolic issues.
http://www.beyondmthfr.com/side-high-oxalates-problems-sulfate-b6-gut-methylation/
https://www.nephure.com/resources/-common-oxalate-sources
Errors in glyoxylate detoxification is a major source of oxalates, toxins especially glyphosate can inhibit this.
https://www.sciencedirect.com/science/article/pii/S0925443912000695
Fluoroquinolone antibiotics kill our good gut bacteria and cause high oxalate levels.
https://floxiehope.com/2016/03/23/fluoroquinolone-antibiotics-and-oxalate-overload/
https://mthfrsupport.com/2017/03/could-floxies-be-dealing-with-an-impaired-glycine-cleavage-system/
We don’t only need oxalate digesting bacteria but we need a diversity of bacteria. That is because some bacteria feed the others and without them they would not get established in the gut and would die off. Consuming oxalates actually promotes gut diversity showing once we address the problem causing the high oxalates we actually need them to improve our microbiomes diversity.
http://msystems.asm.org/content/2/5/e00088-17
https://www.ncbi.nlm.nih.gov/pubmed/29062900
https://link.springer.com/article/10.1007%2Fs00240-014-0728-2
https://www.jci.org/articles/view/72335
http://www.jbc.org/content/292/21/8553.long
https://gut.bmj.com/content/early/2018/04/28/gutjnl-2017-315734.long
https://www.sciencedirect.com/science/article/pii/S0065216410720037?via%3Dihub
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300851/
We need a variety in our diets to feed the bacteria that break down oxalates, we especially need fruit they require a type of sugar found in fruit, honey, maple syrup and organic unsulfured blackstrap molasses.
https://link.springer.com/article/10.1007%2Fs10654-014-9904-5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923490/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235702/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300851/
These are bacteria needed to reduce oxalates. Oxalobacter Formingene,Bififobacterium Adolescentis,Bifidobacteriium Anamalis,Lactobacillus Acidophilus,Lactobacillus Gasseri,Lactobacillus Rhamnosus, and Lactobacillus Planatarum
Enterococcus Faecalis reduces oxalates but consuming to much salt inhibits it’s ability to degrade oxalates.
Inflammation causes high oxalates.
https://www.ncbi.nlm.nih.gov/pubmed/29680019
Metabolic syndrome causes high oxalates from the increase ammonia levels.
https://www.sciencedirect.com/science/article/pii/S2090598X12000848?via%3Dihub
http://www.pnas.org/content/112/8/2569.long
https://link.springer.com/article/10.1007%2Fs00240-017-0979-9
There are even documented cases of paralysis from oxalates.
https://link.springer.com/article/10.1007%2Fs13730-018-0349-7
Oxidative stress can cause oxalates.
https://www.ncbi.nlm.nih.gov/pubmed/19748857
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788594/
Not addressing oxalates can cause non alcohol fatty liver disease and bone loss.
https://linkinghub.elsevier.com/retrieve/pii/S2352-0477(16)30025-9
https://www.sciencedirect.com/science/article/pii/S1658387617301176?via%3Dihub
Oxalates cause mitochondrial dysfunction.
https://www.sciencedirect.com/science/article/pii/S2213231717307565?via%3Dihub
https://www.realizehealth.com.au/2015/12/18/oxalates-yeast-and-mitochondrial-dysfunction/
Oxalates damage the lungs.
https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_0747-18/_article
Oxalates can cause bone marrow loss.
https://link.springer.com/article/10.1007%2Fs11606-013-2618-7
Oxalates cause inflammation which we know can activate the immune system.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807999/
Oxalates cause chronic illness.
http://bioindividualnutrition.com/oxalates-their-influence-on-chronic-disease/
A list of things that will reduce oxalates.
https://chriskresser.com/how-to-prevent-kidney-stones-naturally/
https://www.rebootwithjoe.com/oxalates-kidney-stones-what-you-should-know/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693348/
http://www.raysahelian.com/kidneystones.html
Though I am not keen on drugs they do help with the symptoms until the problem is addressed.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265710/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1455427/
Dandelion reduces oxalates.
https://www.tandfonline.com/doi/full/10.1080/0886022X.2018.1455595
NAC reduces oxalates. If you use it everyday you lose the benefits so I pulse it.
https://www.tandfonline.com/doi/abs/10.1080/10715762.2016.1221507?journalCode=ifra20
Thiamine deficiency causes high oxalates.
https://jcp.bmj.com/content/jclinpath/27/7/558.full.pdf
https://www.hormonesmatter.com/solving-medically-unsolvable-thiamine-oxalates/
Taking more then 4000 IU of vitamin D will cause oxalates. It is why lifeguards have the highest rate of kidney stones. Our skin produces vitamin D from sunlight.
http://www.clinsci.org/content/84/1/51.long
Eating too much meat can cause oxalates especially if you have phenylketonuria it will increase ammonia levels which causes oxalates.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1455427/
Spirulina reduces oxalates but if you have high sulfite levels, CBS or BH4 issues it could actually raise oxalates because it is high in sulfur.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972226/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972226/
Why phenols may make you ill.
B vitamins help with oxalates. When they mention folic acid do not take it, that is man made and toxic to the body you want folate which is natural.
http://oxvox.com/b-vitamins-low-oxalate-diet/
Lemon Juice reduces oxalates because it contains citrate, that is why magnesium citrate reduces oxalates. Also the biofavonoids found in the white parts of citrus fruits reduces oxalates.
https://link.springer.com/article/10.1007%2Fs00240-008-0152-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616898/
Tribulus helps reduce oxalates.
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382010000400011#.WK_WsXrzbYo.facebook
Baking soda reduces oxalates.
https://www.goldjournal.net/article/S0090-4295(13)00304-X/fulltext
Vitamin C can raise oxalates.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096888/
Coffee can prevent kidney stones but I would get organic because glyphosate has been detect on non organic and it causes oxalates.
https://www.nature.com/articles/srep38536
HSP90 contributes to the ill effects of oxalates. I will be doing a post on the heat shock proteins.
https://link.springer.com/article/10.1007/s00775-016-1355-x
https://www.ncbi.nlm.nih.gov/pubmed/20210657
HSP70 protect from oxalate toxicity.
https://link.springer.com/article/10.1007%2Fs00240-007-0130-4
Black Haw helps break down kidney stones.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137613/
https://www.wjgnet.com/2220-6124/full/v3/i4/122.htm
It is the endogenous oxalates that get us.
http://jasn.asnjournals.org/content/18/7/2198.long
Oxalates cause oxidative stress and inflammation.
https://www.ncbi.nlm.nih.gov/pubmed/29091707
https://www.sciencedirect.com/science/article/pii/S2213231717307565
This can lead to renal damgage.
https://www.hindawi.com/journals/omcl/2013/462361/
Inflammation can cause raised osteopontin levels. This can result in high oxalate levels.
https://www.ncbi.nlm.nih.gov/pubmed/24619192
Triggers for high oxalates.
http://nancymullanmd.com/oxalate-options-eliminate-high-oxalate-foods-diet-2/
NADPH oxidases can contribute to oxidative stress.
https://www.selfhacked.com/blog/nicotinamide-adenine-dinucleotide-phosphate-nadph/
https://www.hindawi.com/journals/omcl/2013/271602/
This can lead to lung damage.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361719/
G6PD helps regulate NADPH.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325335/
Many things like glyphosate and glufosinsate can cause G6PD deficiency. Fluoruquinolones can cause it also.
http://www.pathophys.org/g6pd/
oxalate formation
Hydrogen Sulfide produced by gut bacteria can cause sulfation issues.
https://sibosurvivor.com/hydrogen-sulfide-sibo/
In those with acidosis there are nutrient deficiencies, this can cause stone formation. Citrate helps reduce stones in those who have acidosis.
https://www.ncbi.nlm.nih.gov/pubmed/24955227
https://www.ncbi.nlm.nih.gov/pubmed/23675140
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777061/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777061/
Herbs that help reduce oxalates.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693348/
https://www.frontiersin.org/articles/10.3389/fphar.2018.00620/full
https://www.ncbi.nlm.nih.gov/pubmed/21822640
https://www.precisionnutrition.com/all-about-phytates-phytic-acid
Japanese oak leaves reduce oxalates and reduce NADPH oxidase.
