Benefits of angelica.

Written by Lee Stevenson, sorry I am a lousy editor.

This is not medical advice, I have written this for educational purposes. If you are ill please seek the aid of a qualified and experienced functional medicine practitioner.

Angelica (Angelica Sylvestris)

Angelica Sylvestris is the most research. Most are chemically very similar. The newer highbrid forms of angelica I have not seen studies on so most of the studies I post will be on the old world strains of angelica. It most likely would help with corona infection because it prevents leukopenia which is what causes most death in covid illness.

Angelica has a variety of health benefits from protecting bone marrow to helping to heal the gut. Angelica helps to prevent upset stomaches and nausea. It helps reduce the symptoms of inflammatory bowel disease. Angelica is high in coumarins so it does prevent blood clotting. There is not a lot of research surrounding it but it is related to celery and has a mild celery taste. Celery can balance hormones so I suspect Angelica can. If you look at the phytonutrients many of the nutrients it contains are known to help balance hormones. I am partly inclined to believe this because Angelica does decrease the risk of breast cancer.

Nocturia is a conditon where someone has to wake up to frequently urinate. Angelica helps to reduce the symptoms of nocturia.

Angelica root has potent antibacterial properties. It inhibits IL-6 which is what causes most of the damage during Covid infection.

From personal experience many have used it to relax and prevent muscle spasms. Angelica has been shown to reduce anxiety. It has potent anti-inflammatory effects.

Angelica has been found to inhibit the formation of oxalates in the body. It does this by reducing oxidative stress, reducing inflammation and increasing citrate levels. Citrate prevents the formation of oxalate crystals. It also reduces expression of KIM-1 which prevents renal tube damage. It is high in vanillic acid which prevents liver fibrosis or fatty liver disease. Vanillic acid also helps to prevent obesity.

The leaves and stems of angelica contains phytosterols that are known to reduce and prevent arthritis.

Angelica activates Sirt1 which is an antiaging gene. It also prevents the negative effects of endotoxins on the body. Angelica also improves bone marrow health.

Angelica increases T regulatory cells which help restore immune balance in autoimmune diseases. Angelica also inhibits mTor which promotes longevity and prevents muscle atrophy. Many of the nutrients found in Angelica are known to prevent memory impairment. Angelic improves brain function and promotes healing of neurological tissue.

Side effects , it could cause uterine contractions which could cause miscarriage. Consuming excess amounts of angelic can cause photosensitivity.

https://www.medsci.org/v03p0001.htm

https://www.wjgnet.com/1007-9327/full/v18/i7/589.htm

https://www.tandfonline.com/doi/full/10.3109/00365599.2012.695390

https://www.researchgate.net/publication/301356764_In_vitro_Antimicrobial_Activity_of_Angelica_sylvestris_Roots

https://dergipark.org.tr/en/download/article-file/1028195

https://findmeacure.com/2012/02/09/angelica-sylvestris/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773456/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773456/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484959/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620520/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225371/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225371/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328949/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8067363/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321507/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464557/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713235/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309996/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229743/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718036/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987749/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540469/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380541/

High oxalates also known as oxalosis, or hyperoxaluria.

Written by Lee Stevenson, sorry I am not the best editor. I have a book on Amazon I have published on oxalates. I tried to summarize things to help guide people so they could overcome issues with oxalates. It is my only source of income presently. https://www.amazon.com/dp/B0BMJFMQKF

Symptoms of high oxalates are gout, arthritis, kidney stones which causes back pain, gut issues, brain fog, vulvadynia, painful urination, cloudy urine, depression, bladder pain, muscle weakness . Most issues with oxalates are not from the oxalates we consume but health issues that need addressed. I often time get upset when people ask how they can reduce oxalates. It is not a simple question, there are many causes of high oxalates and consumption of foods that contain them are not the main reason because almost all foods have oxalates. Make sure you avoid processed sugar and artificial sweeteners they cause oxalates. Most who have high oxalates also have sulfation issues. I have posted on sulfation. If you have sulfation issues and high oxalates you cannot detox.

https://mthfrsupport.com/2016/02/impacts-to-our-snps-via-foodtoxins-and-the-resulting-domino-effect-on-their-genetic-expression/

https://drjockers.com/low-oxalate-diet/

http://www.lowoxalate.info/research.html

An exception to this is green smoothies. Many plants used in smoothies are high oxalate like kale and spinach they are very high oxalate.

https://www.ajkd.org/article/S0272-6386(17)30863-6/fulltext

https://veganhealth.org/oxalate/

glyoxylate metabolism and oxalates.

https://www.mayo.edu/research/departments-divisions/department-internal-medicine/division-nephrology-hypertension/primary-hyperoxaluria

Oxidative stress can interfere with glyoxylate metablism causing high oxalates.

https://www.hindawi.com/journals/au/2012/819202/

http://jasn.asnjournals.org/content/29/6/1615.long

http://www.mdpi.com/1660-4601/14/1/109

Glyphosate a herbicide found in most of non organic foods effects glyoxylate metabolism causing oxalates. Many farm chemicals found in non organic foods cause oxalates by causing oxidative stress which effects fatty acid metabolism and glyoxylate metabolism

https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(16)30474-3

https://pubs.acs.org/doi/abs/10.1021/acschembio.6b01001?source=cen

Now imagine you are having trouble with glyoxylate metabolism and you are consuming food high in glyphosate. It would not be good.

https://link.springer.com/article/10.1007%2Fs10545-017-0105-8

More in depth information on oxalates.

https://www.greatplainslaboratory.com/articles-1/2015/11/13/oxalates-control-is-a-major-new-factor-in-autism-therapy

Click to access Origin_of_Urinary_Oxalate.pdf

Most oxalates that people have to worry about are endogenous. As for eating oxalates the only time they are a real issues is when we have gut issues. Either we have leaky gut or we are lacking the bacteria that break down oxalates. Cooking destroys oxalates and many of the high oxalate foods like kale and spinach are usually cooked. Most foods contain oxalates and often times the oxalate or being produced endogenously (produced internally) the exogenous oxalates are usually not the problem.

https://www.thepaleomom.com/oxalate-sensitivity-real/

https://scdlifestyle.com/2017/08/oxalates-and-gut-issues/

http://www.beyondmthfr.com/oxalates-and-mthfr-understanding-the-gut-kidney-axis/

Often times the high oxalates are caused by the body itself because of a lack of nutrients or metabolic issues.

http://www.beyondmthfr.com/side-high-oxalates-problems-sulfate-b6-gut-methylation/

https://www.nephure.com/resources/-common-oxalate-sources

Errors in glyoxylate detoxification is a major source of oxalates, toxins especially glyphosate can inhibit this.

https://www.sciencedirect.com/science/article/pii/S0925443912000695

Fluoroquinolone antibiotics kill our good gut bacteria and cause high oxalate levels.

https://floxiehope.com/2016/03/23/fluoroquinolone-antibiotics-and-oxalate-overload/

https://mthfrsupport.com/2017/03/could-floxies-be-dealing-with-an-impaired-glycine-cleavage-system/

We don’t only need oxalate digesting bacteria but we need a diversity of bacteria. That is because some bacteria feed the others and without them they would not get established in the gut and would die off. Consuming oxalates actually promotes gut diversity showing once we address the problem causing the high oxalates we actually need them to improve our microbiomes diversity.

http://msystems.asm.org/content/2/5/e00088-17

https://www.ncbi.nlm.nih.gov/pubmed/29062900

https://link.springer.com/article/10.1007%2Fs00240-014-0728-2

https://www.jci.org/articles/view/72335

http://www.jbc.org/content/292/21/8553.long

https://gut.bmj.com/content/early/2018/04/28/gutjnl-2017-315734.long

https://www.sciencedirect.com/science/article/pii/S0065216410720037?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300851/

We need a variety in our diets to feed the bacteria that break down oxalates, we especially need fruit they require a type of sugar found in fruit, honey, maple syrup and organic unsulfured blackstrap molasses.

https://link.springer.com/article/10.1007%2Fs10654-014-9904-5

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923490/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235702/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300851/

These are bacteria needed to reduce oxalates. Oxalobacter Formingene,Bififobacterium Adolescentis,Bifidobacteriium Anamalis,Lactobacillus Acidophilus,Lactobacillus Gasseri,Lactobacillus Rhamnosus, and Lactobacillus Planatarum
Enterococcus Faecalis reduces oxalates but consuming to much salt inhibits it’s ability to degrade oxalates.

Inflammation causes high oxalates.

https://www.ncbi.nlm.nih.gov/pubmed/29680019

Metabolic syndrome causes high oxalates from the increase ammonia levels.

https://www.sciencedirect.com/science/article/pii/S2090598X12000848?via%3Dihub

http://www.pnas.org/content/112/8/2569.long

https://link.springer.com/article/10.1007%2Fs00240-017-0979-9

There are even documented cases of paralysis from oxalates.

https://link.springer.com/article/10.1007%2Fs13730-018-0349-7

Oxidative stress can cause oxalates.

https://www.ncbi.nlm.nih.gov/pubmed/19748857

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788594/

Not addressing oxalates can cause non alcohol fatty liver disease and bone loss.

https://linkinghub.elsevier.com/retrieve/pii/S2352-0477(16)30025-9

https://www.sciencedirect.com/science/article/pii/S1658387617301176?via%3Dihub

Oxalates cause mitochondrial dysfunction.

https://www.sciencedirect.com/science/article/pii/S2213231717307565?via%3Dihub

https://www.realizehealth.com.au/2015/12/18/oxalates-yeast-and-mitochondrial-dysfunction/

Oxalates damage the lungs.

https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_0747-18/_article

Oxalates can cause bone marrow loss.

https://link.springer.com/article/10.1007%2Fs11606-013-2618-7

http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2018;volume=61;issue=2;spage=268;epage=270;aulast=Sharma

Oxalates cause inflammation which we know can activate the immune system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807999/

Oxalates cause chronic illness.

http://bioindividualnutrition.com/oxalates-their-influence-on-chronic-disease/

A list of things that will reduce oxalates.

https://chriskresser.com/how-to-prevent-kidney-stones-naturally/

https://www.rebootwithjoe.com/oxalates-kidney-stones-what-you-should-know/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693348/

http://www.raysahelian.com/kidneystones.html

Though I am not keen on drugs they do help with the symptoms until the problem is addressed.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4265710/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1455427/

Dandelion reduces oxalates.

https://www.tandfonline.com/doi/full/10.1080/0886022X.2018.1455595

NAC reduces oxalates. If you use it everyday you lose the benefits so I pulse it.

https://www.tandfonline.com/doi/abs/10.1080/10715762.2016.1221507?journalCode=ifra20

Thiamine deficiency causes high oxalates.

https://jcp.bmj.com/content/jclinpath/27/7/558.full.pdf

https://www.hormonesmatter.com/solving-medically-unsolvable-thiamine-oxalates/

Taking more then 4000 IU of vitamin D will cause oxalates. It is why lifeguards have the highest rate of kidney stones. Our skin produces vitamin D from sunlight.

http://www.clinsci.org/content/84/1/51.long

Eating too much meat can cause oxalates especially if you have phenylketonuria it will increase ammonia levels which causes oxalates.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1455427/

Spirulina reduces oxalates but if you have high sulfite levels, CBS or BH4 issues it could actually raise oxalates because it is high in sulfur.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972226/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972226/

http://redmountainclinic.com/the-down-side-to-high-oxalates-problems-with-sulfate-b6-gut-and-methylation/

Why phenols may make you ill.

https://www.anniehelpsyou.com/blog/item/2-are-phenol-oxalate-sensitivities-causing-your-health-problems

B vitamins help with oxalates. When they mention folic acid do not take it, that is man made and toxic to the body you want folate which is natural.

http://oxvox.com/b-vitamins-low-oxalate-diet/

Lemon Juice reduces oxalates because it contains citrate, that is why magnesium citrate reduces oxalates. Also the biofavonoids found in the white parts of citrus fruits reduces oxalates.

https://link.springer.com/article/10.1007%2Fs00240-008-0152-6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616898/

Tribulus helps reduce oxalates.

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382010000400011#.WK_WsXrzbYo.facebook

Baking soda reduces oxalates.

https://www.goldjournal.net/article/S0090-4295(13)00304-X/fulltext

Vitamin C can raise oxalates.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096888/

Coffee can prevent kidney stones but I would get organic because glyphosate has been detect on non organic and it causes oxalates.

https://www.nature.com/articles/srep38536

HSP90 contributes to the ill effects of oxalates. I will be doing a post on the heat shock proteins.

https://link.springer.com/article/10.1007/s00775-016-1355-x

https://www.ncbi.nlm.nih.gov/pubmed/20210657

HSP70 protect from oxalate toxicity.

https://link.springer.com/article/10.1007%2Fs00240-007-0130-4

Black Haw helps break down kidney stones.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137613/

https://www.wjgnet.com/2220-6124/full/v3/i4/122.htm

It is the endogenous oxalates that get us.

http://jasn.asnjournals.org/content/18/7/2198.long

Oxalates cause oxidative stress and inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/29091707

https://www.sciencedirect.com/science/article/pii/S2213231717307565

This can lead to renal damgage.

https://www.hindawi.com/journals/omcl/2013/462361/

Inflammation can cause raised osteopontin levels. This can result in high oxalate levels.

https://www.ncbi.nlm.nih.gov/pubmed/24619192

Triggers for high oxalates.

http://nancymullanmd.com/oxalate-options-eliminate-high-oxalate-foods-diet-2/

NADPH oxidases can contribute to oxidative stress.

https://www.selfhacked.com/blog/nicotinamide-adenine-dinucleotide-phosphate-nadph/

https://www.hindawi.com/journals/omcl/2013/271602/

This can lead to lung damage.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361719/

G6PD helps regulate NADPH.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325335/

Many things like glyphosate and glufosinsate can cause G6PD deficiency. Fluoruquinolones can cause it also.

http://www.pathophys.org/g6pd/

oxalate formation

Hydrogen Sulfide produced by gut bacteria can cause sulfation issues.

https://sibosurvivor.com/hydrogen-sulfide-sibo/

In those with acidosis there are nutrient deficiencies, this can cause stone formation. Citrate helps reduce stones in those who have acidosis.

https://www.ncbi.nlm.nih.gov/pubmed/24955227

https://www.ncbi.nlm.nih.gov/pubmed/23675140

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777061/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777061/

Herbs that help reduce oxalates.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693348/

https://www.frontiersin.org/articles/10.3389/fphar.2018.00620/full

https://www.ncbi.nlm.nih.gov/pubmed/21822640

https://www.precisionnutrition.com/all-about-phytates-phytic-acid

Japanese oak leaves reduce oxalates and reduce NADPH oxidase.

https://www.researchgate.net/publication/287565171_Promoting_effect_of_extract_of_Quercus_salicina_BlumeQ_stenophylla_Makino_UROCALUNR_on_urinary_stone_passage