Written by Lee Stevenson, sorry I am a lousy editor.
This is not medical advice I am writing this for educational purposes. If you are ill please seek the aid of a qualified and experienced functional medicine practitioner.
Nicatinomide
Nicatinomide increase NAD+ which is needed by every cell in the body. As we age or get chronically ill we lose the ability to produce NAD+ in adequate amounts. Nicatinomide is a form of niacin (B3). Nicatinomide has been shown to reverse many of the effects of chronic illness and aging. It is needed for glycolysis which is involved in burning fats stored in the liver to produce glucose for the body. NAD+ is also involved in fatty acid oxidation which is the bodies way of burning fats to produce glucose for the body. If glycolysis is inhibited a person will develop fatty liver disease, if beta oxidation is inhibited a person will develop diabetes and hypoglycemia. NAD+ is involved in the proper function of all the antiaging genes. NAD+ is also involved in many of the function that protect us from infections including viral infection. So nicotinamide helps to prevent diabetes, obesity and many age related diseases.
Nicatinomide helps to prevent neurological damage and damage to the brain and improves brain function. It improves learning and memory. It has been found to help prevent depression. It also prevents damage to the brain by improve the function of many pathways in the body preventing toxic metabolites from being produced.
Nicatinomide improves function of the antioxidant system which would protect DNA. Nicatinomide also improve DNA repair. Nicatinomide also improve RNA processing and protects it from premature degradation.
Nicatinomide improves indurance and stamina by improving the bodies ability to burn fats for energy. Fat is the bodies main source of energy. When it cannot burn fat for energy and has to rely on glucose a person will develop frequent episodes of hypoglycemia. With hypoglycemia a person may experience headaches, lightheadedness, dizziness, heart palpitation, feeling flush or hot and may even sweat severely. The reason for the frequent boughts of hypoglycemia is that glucose is rapidly consumed for food and the glucose from fats is released slowly which keeps the glucose levels stable in the body.
Nicatinomide helps to prevent autoimmunity by keeping the immune system balanced. It also improves the ability of the immune system to respond to infection. It helps to prevent many types of viral infection including herpes, corona, the flu and many others.
Nicatinomide also improve the function of the circadian rhythm our bodies natural clock.
Nicatinomide also improves function of the citric acid cycle.
Because NAD+ reduces oxidative stress and inflammation it also helps to prevent cardiovascular disease.
Nicatinomide also improves muscle endurance and strength. It also prevents muscle degeneration.
NAD+ also helps prevent the build of of fibrotic tissue in the body which can cause organ failure so it helps to protect the organs.
It should be taken with food because if taken on an empty stomach a person will experience nausea, fatigue, headaches, diarrhea, stomach discomfort and indigestion. It should not cause flushing like niacin does. From what I could tell a person can take up to 1000 to 2000 mg daily but I would research which is the best amount to take. Excess nicotinamide consumption can inhibit growth of new cartilage and it also inhibits the genes that protect the body from cancer. So once the health issue is addressed that required the consumption of nicotinamide I would recommend pulsing it or discontinuing it’s use if it is no longer needed. I would not take super high doses of nicatinomide.
Nicotinamide has been shown to reduce the occurrence of acne.
https://www.healthline.com/nutrition/nicotinamide-riboside#risks-and-side-effects
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795269/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539288/
https://pubmed.ncbi.nlm.nih.gov/27508874/
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