This is not medical advice , I am posting this for educational and informational purposes.
These are my notes of things I researched to recover. I have much more to add to it but figured I would post what I have typed up so far. This is not in order and inflammation is very very important to address in order to be able to detox endotoxins.
This is not medical advice, I am putting this here for informational and educational purposes. My advice on reading this because it is very long is skip over things that do not seem to concern you and the issues you are dealing with. I had many health problems I had to deal with and these are my notes. It seems I had more then usual so my notes are extensive. From what I am learning most do not experience the number of health issues I had. I need to cover oxidative stress first because it is the main cause of the symptoms of sepsis.
Many take CoQ10 for their fatigue. I would say it is better to avoid but supporting NADPH might be a better option. I noticed I got worse when I took CoQ10 but Ubiquinol seemed to work fine for me.
Oxidative Stress is caused by an imbalance in our antioxidant system. When there is an imbalance taking antioxidants will increase the damage in the body. We must address what is causing the imbalance before taking antioxidants. Taking antioxidants when there is an imbalance in the antioxidant system also makes us more prone to health issues especially cancer. An imbalance in or inhibited redox cycling and blocked Nrf2 pathways are the most common issues involving excess oxidative stress.
This results in the production of peroxides and free radicals. This damages components of the cells including lipids and DNA , they cause strand breaks in the DNA preventing it from repairing . This is why high LDL levels are a sign of oxidative stress. High cholesterol indicates an imbalance in the antioxidant system. This can be caused by toxins like heavy metals, the many farm chemicals found in our food, toxins in processed food, heavy metals, infections and the endotoxins from dying pathogens, many of the toxins in vaccinations can cause oxidative stress,and stay in the body a very long time, especially the aluminum in vaccinations. To restore balance we need to detox whatever is causing the imbalance, also address any metabolic issues causing the imbalance. The hydrogen peroxide produced from the reactive oxygen species can act as cellular messengers which cause a disruption in normal mechanism in cell signaling. This causes redox cycling to be inhibited and has been linked to many forms of chronic illness. Nrf2 regulates the antioxidant system and toxins, infection and bad diets can inhibit the Nrf2 pathways. Excess oxidative stress causes adenosine triphosphate (ATP) depletion. ATP is important in molecular cellular energy transfer. This causes apoptic cell death to be inhibited so the cell simply falls apart. When the cell is not removed by apoptosis it can cause a build up of cellular debris in the body which has many negative health effects. Inflammation can inhibit the bodies ability to remove toxins and waste which can contribute to oxidative stress. Over production of ROS can lead to stroke, hypertension, hardening of the arteries, heart attacks, and failure of organs. It can result in damage to the brain resulting in impaired thinking and even mental illness.
There are many sources of reactive oxygen species in the body. Xanthine Oxidase is an enzyme that generates reactive oxygens species it is found in the blood and lungs. It’s activity is increased during infection. Levels of xanthine oxidase are increased during liver damage. It has been found to be high in gout. Phytic acid inhibits xanthine oxidase. Remember homeostasis is the goal because the antioxidant system protects us we do not want to keep inhibiting it. Once we get inflammation down and the peroxide, and free radical levels down we want to maintain homeostasis.
Free radical from oxidative stress deplete cofactors involved in electronic transport, DNA repair. Damaged (Fe-S) clusters can cause iron overload. It also causes inhibition of lipoic acid synthase which is involved in amino acid metabolism and glycine degradation. When inhibited it results in encephalitis and lactic acidosis. This also causes a build up of hydroxyl radicals. NADPH oxidase is activated by infections and certain cytokines. Arachidonic acid (omega 6) also stimulates activity of NADPH oxidase Apocynin found in many plants inhibits NADPH oxidase. I do not know which plants but most research papers state apocynin found in many types of plants. Inhibition of NADPH can cause granulomas to form. This is the bodies way of blocking off something it cannot rid from the body. So do not over do it. Nitric Oxide also inhibits NADPH oxidase. Arginine and citrulline can help increase NO.
Superoxide Dismutase comes in three forms in the body, SOD1 is located in the cytoplasma inside of cells, SOD2 located in the mitochondria, SOD3 is extracellular. SOD serves as a key antioxidant. Low SOD levels increases the risk of cancer. SOD has anti-inflammatory effects. SOD decreases ROS and oxidative ss, and interstitial cystitis. It also reduces inflammation in the urinary tract. SOD also prevents liver and kidney damage and protects us from radiation damage. The most bioavailable form of of SOD is found in the chaga mushroom but it is also found in phytoplankton, horseradish, and cantaloupe. If you have iron toxicity it will inhibit SOD. Lactoferrin helps restore the bad iron back to good and helps the body get rid of excess iron. Curcumine chelates iron but if taken to often or too much it can cause anemia. Infection can cause the body to store copper in our soft tissue to prevent pathogens from using iron. This also prevents the body from using iron, it kills the pathogen but inhibits SOD production. Natural sources of vitamin C will get the body to release the copper from the soft tissue. High doses of vitamin C can cause red blood cells to break down so don’t get carried away. Also man made vitamin C can cause oxalates. Manganese is needed for SOD production but should not be taken in high doses it can be toxic if we get too much in the body. Zinc is also needed for SOD production , honey is high in zinc.
Low SOD3 can cause acute respiratory distress syndrome which is when fluid leaks into the lungs. It has also been linked to COPD.
Glutathione and SOD are tightly linked so I will cover it next. Resveratrol also activates SOD it is found in grape seed extract.
We need to find balance because high levels of SOD has been show to make us susceptible to certain types of cancer. Homeostasis should be the goal then do things to maintain homeostasis.
Glutathione peroxidase is a general name for a group of enzymes with peroxidase activity. Gps main biological role is to protect from damage from oxidative stress. GP reduces lipid hydroperoxides to their corresponding alcohols. Lipid hydroperoxides are caused from the oxidative degredation of fats. It mostly effects polyunsaturated fatty acids. There are several documented cases of anemia from GP deficiency, most likely if they measure the Fe3 iron it would be high. The iron in the plasma was probably in a form the body could not us.
GPx1 increases reactive nitrogen species ability to cause cell death and can cause insulin resistance. So it is important to make sure reactive nitrogen species are not high.
How Nitric Oxide Species are produce.
This is a link to a more in depth article I did on Nitrosative Stress.
If you have been reading the links in my post you know by now that lipopolysaccharides a component of endotoxins is responsible for the systematic inflammation that endotoxins cause. Lipopolysaccharides are a component of many pathogens. It is very important to reduce the level of LPS in the body to reduce chances of sepsis which results in chronic illness. LPS can cause a bunch of issues that prevent us from detoxing which causes many other issues. In order to detox LPS we need to address those issues. I am going to place these links here so when you decide the approach you may want to take you can look at nutritional options that may help after you have read the article and get a better understanding of endotoxemia these can be used for a reference.
It is very important to reduce LPS because it has a dramatic effect on our brain. It can cause anxiety, dissociative behavior, emotional dysfunction. It also impairs memory. It can cause fatigue and even disrupt the reproductive cycle. High LPS levels have been linked to things such as diabetes, heart disease, mental illness, cancer, obesity, metabolic disorders, renal disorders, autism, hearing and eye health can be negative impacted. LPS also cause digestive disorders like SIBO, IBD, IBS and dysbiosis. LPS contributes to arthritis and increased allergies. LPS has even been linked to PCOS in women. LPS causes adrenal fatigue. It can cause many skin disorders like lupus or psoriasis. It can contribute to bone loss. It causes neurological damage throughout the body.
Endotoxins also cause hormone imbalances and thyroid problems.
There are gut bacteria that reduce LPS, Bifidobacterium, Lactobacillus GG, Saccharramyces Boulardii Bacillus Infantis, B Longhum, Clostridium Butyricum, E Coli Nissle 1917, Lactobacillus Brevis, L Casei, and many others.
Fruit pectin reduces LPS. The pectin is the waxy substance found on the skins of many fruits. One of these articles mentions corn flakes. Corn is GMO and causes leaky gut which would make things worse. I do not recommend eating any GMOs they themselves can cause sepsis.
Exercise reduce LPS.
Stimulating the vagus nerve decreases LPS and inflammation.
Polyphenols reduce LPS. These are usually highest in darker colored fruits and vegetables.
Resistant starch decreases LPS by increasing the good gut bacteria. This should be introduced slowly because when the good gut bacteria increase the bad die off which will cause bloating and herxing. I got very ill when I tried to eat resistant starch. I had to start with small amounts and slowly increase my intake.
LPS and Fats
Diets high in bad fats, like transfats and saturated fats increase the effects of LPS.
These sites suggest ways to reduce LPS. I do not agree with all their methods so always take things with a grain of salt and do your research. Many have metabolic issues that need addressed before taking some of the suggested things in these articles. For example those with high sulfite levels or CBS or BH4 issues would become ill from some of the things suggested because they are high in sulfur. Those with Pyrrole issues will become ill from any types of fats so Omega 3s will cause problems. So before you can even attempt to detox LPS you need to address any metabolic issues or you will be running on a hamster wheel of ill health getting no where because the things needed to heal will make you ill.
LPS Causes Leaky Gut
LPS causes leaky gut, leaky gut causes our bodies to absorb more LPS. Here is another area where the cycle must be broken. Just as with high oxalate levels it is difficult to heal the gut , high LPS levels make it difficult to heal the gut. I have posted articles that will help with information on healing the gut so I will not cover it in detail but if time permits I will post the links to the articles. Healing the gut is very important in order to break the cycle.
These are articles I did that have information that may help with leaky gut.
Activated charcoal helps reduce LPS but should not be taken to soon after eating. It will inhibit nutrient absorption.
If the leaky gut is not addressed we develop metabolic endotoxemia.
Polyunsaturated fats should be avoided. The body only needs a small amount of them. When the levels get to high in the body they negatively impact our health. These are found in things such as corn oil, canola oil, cotton seed oil, and soybeen oil. They also contain transfats which really need to be avoided. Fats from things like fresh cod liver oil which should be refrigerated. If it smells fishy then it has oxidized and has lost some of it’s benefits, other sources are coconut oil, beef tallow,lard and butter contain the fats that our bodies need. The tallow, lard and butter should be from grass feed beef. We need PUFAs in our diet but in the form of Omega 3s. We have to do our best to prevent the Omega 3s from oxidizing. The previously mentioned oils are high in Omega 6 , our Omega 3 levels should be higher then Omega 3s but processed food is high in Omega 6 and is why many have inflammatory diseases.
It is very important to protect the liver while detoxing endotoxins because it is hit pretty hard and can get damaged. Burdock root and sarsparilla root seemed to help me. Rooibos tea was another herb that really helped me, it is great for oxidative stress and inflammation. Sculletaria is another one that seemed to really help me. Bayberry has also been found to support the kidney and liver.
Here is a very good article explaining detoxing.
Endotoxins cause oxidative stress which results in the oxidation of lipids. The can result in damage throughout the body and is why many have high oxLDL levels. High LDL is a symptom not a cause. It is very important to also address the oxidative stress caused by endotoxins. This includes restoring the balance of our gut bacteria which protects us from oxidative stress. If they are out of balance they can actually contribute to oxidative stress. It is why those who take the same probiotic daily usually end up sicker. They get too much of specific strains of gut bacteria and are preventing their gut bacteria from balancing out. Cholesterol is an antioxidant and an anti-inflammatory. Reducing cholesterol would do the opposite of what we want. It would increase inflammation and prevent the body from healing.
Vitamin E reduces oxidative stress from LPS but the most effective is a-tocopherol. A-tocopherol is found in wheat germ, liver, egg yolk and nuts. Green leafy vegetables are high in it but most are high oxalate especially spinach so must be cooked to break down the oxalates. I have posted on supplements so I will not get into detail but will list the most effective ones here.
Nicotinamide reduces oxidative stress from endotoxins.
Foods that help increase nicotinamide are milk , yeast , mushrooms,fish, green vegetables and beer. Most beer is GMO it must be organic because the harm GMOs do would defeat the purpose.
Lycopene reduces oxidative stress. Foods high in lycopene are tomatoes, watermelon, guava, papaya, sweet red peppers, purple cabbage, and mango. Some foods like tomatoes when cooked increases the amount of lycopene the body absorbs.
Carbon dioxide reduces LPS damage but increasing it has to be done with caution. You can increase carbon dioxide by breathing into a paper bag for a short period of them. I would not do this for long though. It takes a while for oxygen levels to return to normal. I do not recommend trying this I put it here for others to research farther. Those with COPD, asthma, or lung damage would not fair well doing this.
Because LPS increases estrogen because it prevents the body from detoxing it, it is important to decrease estrogen. Some medications increase estrogen, stress increases estrogen, nutrient deficiencies increase estrogen, environmental toxins can increase estrogen, emotional stress can increase estrogen. Many view estrogen as a female hormone, men can have high estrogen levels also. Oxidative stress caused by LPS causes nutrient deficiency which prevents the body from detoxing estrogen. It is very important to get the nutrients we need. Especially minerals and fats. Flouride, fluoroquinolones, farm chemicals especially glyphosate increase estrogen. It is best to eat organic when possible. Sunlight helps detox estrogen when we get it in moderation. Those who avoid getting sun have higher rates of cancer. Those who get too much sun have higher rates of kidney stones. So moderation is the key. There is not much research on reducing estrogen but when the other things are addressed and the detox enzymes are functioning again your body will detox the excess estrogen. Fiber also lowers estrogen. High estrogen levels cause lipid oxidation this can result in high triglyceride levels. High tryglycerides are a symptom and not a cause.
B vitamins are very important in detoxing estrogen. When taking folate do not confuse it with folic acid which is man made and has many negative effects on the body.
It is important to reduce inflammation. Inflammation can inhibit bile, inhibit the bodies ability to detox, it also can cause autoimmune disease. Bile detoxes many things in the body including LPS and it prevents it from entering the body through the digestive tract. If you get constipated or it feels like you have a brick in your stomach after eating then you may have inhibited bile production. This will cause you food to sit in the upper part of the digestive tract and it will ferment instead of digesting which causes many health problems. Cholesterol is needed to produce bile. If we have excess oxidative stress our cholesterol will get oxidize and it is another reason we must address oxidative stress and reduce it. Fats are also needed to produce bile, this also gets oxidized from oxidative stress. Also the metabolic issues like porphyria can cause problems with fat metabolism and is why it is very important to address metabolic issues. I have posted supplements that help with these issues. If you look through the list COX , inhibitors, anti-inflammatory nutrients will help to reduce inflammation. There are many things involved in the production of bile. Even our gut bacteria modulate bile production. Inhibited bile production can also cause problems with the gall bladder. Sulfation is also important factor in bile production so if you have high sulfite levels from gut dysbiosis, candida, CBS or BH4 issues then you need to address those also. Polyunsaturated fatty acids cause a decrease in the livers ability to detox estrogen.
Things that increase bile are lemon water, artichoke, dandelion root, foods high in sulfur. Taurine deficiency which is common in vegetarians can cause inhibited bile production. Taurine has been shown to increase bile flow.
Our gut bacteria also can cause inflammation if we are deficient in certain strains.
Bile aids in the absorption of healthy fat. If we have poor bile production it can have dramatic effects on the whole body. Every cell in the body needs fat, the brain is mostly fat so fat malabsorption effects the whole body.
Many think their indigestion is from acid reflux but often times it is from inhibited bile production. Inhibited bile could cause a deficiency in fat soluble vitamins especially vitamin K. Antibiotics also reduce the gut bacteria that produces vitamin K which can add to the problem.
This is a very in depth article on bile.
Endotoxins damage betadorphin nerves in the hypothalamus. This results in raised cortisol levels. This is another reason why it is very important to address inflammation. This results in insulin resistance and suppressed progesterone production. LPS causes high histamine levels , progesterone and testosterone are needed to protect us from histamines. There is supplements mentioned in my post on supplements that discusses ways to reduce histamines this is also cover in my post on how our gut bacteria effect our genes. We have histamine reducing bacteria. Adaptogenic herbs help with the adrenal fatigue caused by LPS.
LPS stimulates liver kupffer cells which can cause a rise in reactive oxygen species and inflammatory cytokines. The body can get stuck in a cycle that escalates and the inflammation and oxidative stress will keep increasing. This is why it is very important to address oxidative stress, inflammation and work on detoxing LPS and excitotoxins so the cycle can be broken and healing can begin. If not broken this can result in liver fibrosis. Because kupffer cells are needed to detox LPS we do not want to inhibit them but we need to detox, and address metabolic issues and oxidative stress.
Bradykinin – it is a peptide that causes blood vessels to dilate, which decreases blood pressure. Bradykinan stimulates the release of Nitric Oxide, Postacyclin, Endothelium-derived hyperpolarizing factor. This allows the smooth muscle to relax , increasing their diameter which reduces blood pressure. Bradykinin raises internal calcium levels in neocortical astrocytes. Astrocytes fuel neurons with energy during times of stress , physical exertion, and periods of fasting. They are important in the flow of blood to the brain. Astrocytes clear excess postassium in extracellular space. Excess potassium can cause epilepsy. Astrocytes in the hippocampus suppress synaptic transmition by releasing ATP which through a number of processes produces adenosine. Adenosine prevents tachycardia. Astrocytes promote the healing of nerves but if over stimulated can cause nerve damage. Astrocytes can also promote nerve cell and brain cell growth. ACE inhibition raises bradykinin and causes the dry cough people get from taking ACE inhibitors. High bradykinin levels causes asthma, and swelling in legs , face, and abdomin. High bradykinin levels also causes vomiting and airway obstruction. Bromelain, aloe vera, and polyphenols reduce the effects of bardykinin.
HPA axis is important in the homeostasis of bradykinin.
This is an description of bradykinin and the health effects.
bradykinin prevents blood clotting.
Bradykinin can increase inflammation in our lungs during infections.
So we can see not enough bradykinin can effect our health as much as too much bradykinin. Homeostasis should be the goal with all our health goals. Once we reach homeostasis then we need to work towards maintaining it to prevent over doing things which can cause just as much harm.
High bradykinin levels can cause low blood pressure, tachycardia, blood vessel leakage, it can cause inflammation especially in the salivary glands. Bradykinin also raises substance P which causes burning in the scalp and down the spine, also can be felt in the skin and increases at night. ACE inhibitors raise bradykinin levels.
Glycosides like astilbene and eurcrypin inhibit bradykinin. Also keep in mind histamines and inflammation stimulate bradykinin so we must reduce those also. Most plant polyphenols will reduce bradykinin especially grapes and the white part of citrus fruit. Also if we do not have high sulfite levels , high sulfur foods reduce bradykinin.
Hormones and their effects.
Adenosine- is involved in the regulation of blood pressure. If deficient a person could develop high blood pressure and tachycardia. It reduces inflammation by suppressing the activity of most immune cells. A deficiency can be caused by excess inflammation and immune responses. This can result in muscle fatigue. D-ribose has been found to help reduce the fatigue. So those with lung disease , cardiovascular disease or low immune function could be effected by adenosine.
Symptoms of adenosine deficiency would be muscle fatigue will exercising and frequent infections in the lungs. A deficiency in adenosine causes a loss of T regulatory cells. Symptoms of this are conditons such as eczema , and also type 1 diabetes. Adenosine deficiency also causes hypoxia. Excess adenosine can result in asthma. When cells are stressed or damaged adenosine increases. This is why I freqently say homeostasis should always be the goal. Those with low adenosine may have trouble sleeping.
Lactobacillus Reuteri helps reduce the symptoms from adenosine deficiency.
Excess adenosine and the complications from it. This is a caused by a deficiency in adenosine deanamase.
Causes Asthma and other lung inflammatory diseases.
Gotu Kola contains asiatic acid which helps with ada deficiencies.
Excess adenosine can cause prolonged painful penile erections which can result in damage to the penis.
Adenosine signaling is elevated in sickle cell anemia. Increasing Adenosine Deaminase would help.
Hyeprthyroidism causes raised adenosine levels showing that we must protect the health of the thyroids.
Adenosine Deaminase breaks down adenosine. A deficiency causes many health problems because of raised adenosine levels. It can lead to skeletal issues, mental deficiencies, immune dysfunction, and hearing loss.
Curcumin inhibits ADA so should be avoided by those who have low ADA levels. There are nutrients that help support ADA production.
Hypothyroidism causes reduce adenosine levels.
AdA levels can effect thyroid health.
adenosine restores neutrophil chemotaxis endotoxins inhibit the bodies ability to locate infections. Adenosine restores this ability.
Adiponectin is a protein hormone involved in regulating glucose levels in the body. It plays a role in the endocrine system, and metabolic and inflammatory signaling. Issues with adiponectin have been tied to ADHD, diabetes, and arthritis. Those who have type 2 diabetes, obesity, hyperlipodemia, and arthritis have been shown to have low adiponectin levels. Those with low adiponectin have a higher risk of cardiovascular disease.
Adiponectin protects us from cardiac injury from endotoxins.
Adiponectin is produced in fat cells and muscle cells.
EPA and DHA increase adiponectin.
Palmitic acid increases the brown fat needed to produce adiponectin.
Chrysin found in high levels in flowers and honey increases brown fat.
Those with low adiponectin have a higher risk of cardiovascular disease.
Phytic acid improves adipose differentiation improving the function of brown fat this improves insulin sensitivity. Phytic acid is found in grains and nuts. Eat food high in phytic acid in moderation it is an anti nutrient. Phytic acid also reduces sepsis.
The importance of improved cell differentiation in our brown fat is that it regulates the homeostasis of many things within out bodies.
So here is how to increase brown fat.
Our diet influences our adiponectin levels.
Alpha-Melanocyte Stimulating Hormone
Alpha-Melanocyte Stimulating Hormone- it is an endogenous hormone and neuropeptide. It is one of the proteins responsible for hair and skin pigmentation. It plays a role in our feeding behavior, energy homeostasis in the body and even our sexual activity. It protects from injury that results from restricted blood flow, it also protects from the injury that results when the blood flow is restored. When blood flow has been restricted and then is restored it results in oxidative stress and inflammation. It also has antimicrobial properties.
It helps prevent sepsis.
Glucose stimulates a-msh production which helps regulate glucose homeostasis.
Excess oxidative stress depletes a-msh.
It also protects us from the Nrf2 inhibiting effects of UVB rays thus protecting us from oxidative stress.
Low a-msh results in increased appetite, inflammation, increased pain, difficulty sleeping, and dehydration which results in low blood pressure from the excessive water excretion. Vaccinations, heavy metals, fluoride,fluoroquinolone drugs, glyphosate and other farm chemicals damage the pineal gland which has effects on the levels of a-msh. We also have a higher risk for cancer when it is low.
It improves the bodies ability to heal.
This is why it is very important to get sun light in moderation. Sun light controls homeostasis of many body functions and is a much needed nutrient. Yes I am calling it a nutrient. It is the best way to describe sun lights effects on the body.
I am not certain what the effects on those suffering from Addison’s disease would be but they produce it in excess. Excess a-msh can cause a loss of appetite even cause nausea and vomiting, weakness, hypotenion and liver fibrosis.
Brain Nutriuretic Peptide
Brain Nutriuretic Peptide – is a hormone secreted in heart muscle cells. It reduces blood pressure, it reduces renal sodium reabsorption and increases the break down of fats. It reduces the release of aldosterone in the adrenal cortex. Aldosterone causes a reabsorption of salt and water into the body and a loss of potassium which results in high blood pressure. Those with Addison’s disease and chronic fatigue syndrome were found to have the opposite problem they have too much BNP in their bodies.
BNP is released during strokes to protect the brain from injury.
Oldly enough high BNP levels increases the risk of high blood pressure in men but not women. It is released when the arteries start hardening, most likely to try and protect the body. Most know by now hardening of the arteries is caused by oxidative stress and inflammation. So high BNP levels would indicate a problem that needs addressed. I do need to research this more because I could not find much information on decreasing or increasing BNP safely.
Those who are deficient in BNP are more succeptable to fibrosis and lung disease.
BNP is also a contributing factor to the myocarditis caused by endotoxins.
Studies have shown that issues in the renal system can effect BNP levels. Most issues with the renal system are caused by toxins or infections, sometimes a lack of certain microbiotia in the gut.
BNP increases cortisol and catecholamine levels. There are adaptogenic herbs that reduce cortisol but not sure if they would help with this.
Things that reduce BNP also reduces cortisol so I would say there is a feedback loop between the two and reducing cortisol would reduce BNP and vice versa.
Things that raise BNP are excessive alcohol consumption, smoking, stress, sleep deprivation, NSAIDs, oxidative stress, inflammation. So reducing oxidative stress, meditate and do other things to reduce stress, get plenty of sleep, stop smoking if you smoke, consume alcohol in moderation, use natural methods of reducing inflammation instead of NSAIDs shoulld reduce BNP and cortisol.
Calcitonin Gene Related Peptide
Calcitonin Gene Related Peptide is another mechanism the body uses to protect itself. It is released during pain or other stimuli that can indicate harm to the body. Is is found in the nerves throughout the body. It is released during inflammation in nerves and from activation of the capsaicin receptors in the gastrointestinal system. It is a vasodilator so can reduce blood pressure and prevent cardiovascular disease. If too high in the body it can cause high systolic blood pressure. It also causes head aches if levels are too high. Raise levels cause the nerves to become sensitive. Serotonin reduces CGRP. Low estrogen causes a rise in CGRP and is why many experience headaches around the time of their menstruations. Things that contain phytoestrogens may help with this.
I do not recommend trying to increase CGRP because substance P is usually high in those with endotoxemia and it increases the potency of substance P.
It inhibits the inflammation caused by endotoxins.
CGRP helps protect the lungs from injury.
It may be involved in bone repair.
If levels are too high there are natural inhibitors. Proanthocyanidins increases serrotonin which reduces CGRP. Avoid capsaicin it is a CGRP activator.
Mast cells are one of the bodies first responses to an invader even in parasite invasions. They accomplish this through extracellular trap formation. They also release antimicrobial agents. Some pathogens like tuberculosis have developed strategies to avoid destruction by mast cells. Lyme is another infection that has developed more strategies to evade the immune system the HIV.
Under normal conditions mast cells will reduce inflammation
When endotoxin levels get high then mast cells start to break down which causes high histamine levels. This results in allergies and sensitivities.
Because some pathogens can evade the effects of mast cells in removing them it can set off mast cell activation syndrome or mastocytosis. Both disorders are very similar and difficult to tell appart.
Description of mastocytosis. Symptoms can be skin rashes or lesions, difficulty breathing, swelling under the skin or in the mucous membranes, diarrhea, low blood pressure, bloating, Inhibiting inflammation, cox, and reducing histamines helps resolve this. I have mentioned in the links at the beginning of this article things that help reduce histamines and on another post I did no gut microbiome I mention probiotics that will reduce histamines. The symptoms of Mastocytosis and mast cell activation syndrome are similar and how to resolve it are the same.
Because LPS causes leaky gut it can result in mast cell activation , which leads to food intolerance and allergies. This in turn can lead to many metabolic issues.
Proenkephalin and Kyotorphin
proenkephalin an kyotorphin are neuroactive dipeptides that plays a major role in pain regulation in the brain. They release met-enkephalin which has opioid like effects. Low levels of kyotorphin causes persistent pain. It also reduces inflammation similar to how steroids do.
Has effects of endotoxin induced inflammation similar to how steroids would.
They are neuroprotective
Kyotorphin levels have been found to be low in those with alzheimers.
kyotorphin has antimicrobial properties.
Oxygen deprivation stimulates the release of kyotorphin.
Met-enkephalin reduces symptoms of chronic inflammatory diseases.
hypothalamus-adrenal-axis regulates met-enkephalin so it is important to reduce inflammation, histamines, and toxins because they can have a negative impact on them. Vaccinations, farm chemicals, fluoride and drugs, especially fluoroquinolone have been shown to disrupt the HPA axis. Stress and lack of sleep also disrupt the HPA axis. Thiamin deficiency can have a negative impact on the HPA axis and glyphosate causes many nutrient deficiencies. Many of us are in very stressful situations we cannot get out of, we must learn to remain calm because it will effect the HPA access. I know it can be difficult but if we don’t win that battle we will lose the long term battle.
Those who are G6PD deficient or have certain metabolic issues would get ill from the foods that contain thiamine so they may have to supplement thiamine until they have corrected those issues.
Melatonin – is one of the bodies most powerful antioxidants. It is produced in the pineal gland. It regulates our sleep wake cycles. It is a powerful anti-inflammatory. It also regulates our blood pressure. It can be found in our food. Foods that contain it are bananas, grapes, rice, grains, plums, olive oil, pineapple, and oranges. I do not believe in taking things orally because often times taking things orally can disrupt the bodies ability to produce the substance so I try my best to stimulate the production or find food sources. Inflammation disrupts the production of melatonin.
Those who are G6PD deficient or have certain metabolic issues would get ill from the foods that contain thiamine so they may have to supplement thiamine.
Melatonin helps prevent endometriosis.
Over consumption of alcohol causes leaky gut, we know leaky gut raises endotoxin levels. This leads to a reduction in metatonin.
We know inflammation, toxins , stress, and many other things cause oxidative stress which cause high hydrogen peroxide levels. Melatonin reduces oxidative stress. Hydrogen peroxide causes severe damage throughout the body including the blood brain barrier which makes the brain succeptable to injury and infection.
Unnatural light especially blue light like what is emitted by computer and cell phone screens disrupts our ability to produce melatonin. Sunlight stimulates melatonin production. Many things have cause magnesium deficiency which is needed to produce melatonin. Over farming has depleted nutrients from the soil, glyphosate and glufonisate chelate minerals from the soil, they are chemicals used in modern day farming.
There are many benefits to getting sunlight in moderation.
Norepinephrine, also known as Noradrenaline.
Norepinephrine – it is an amino acid derivative that functions as a hormone and neurol transmitter. It is produced in the adrenal glands and an area of the brain stem that is responsible for our responses to stress and panic. It functions to mobilize the body to action. It rises when we wake and in the presence of danger or stress. It enhances memory retrieval . Too much norepinenphrine causes restlessness and anxiety. It increases heart rate and triggers the release of glucose. It increases blood flow to the muscles. It reduces blood flow to the gastrointestinal system and inhibits bladder voiding. So it can cause inhibited digestion and difficulty voiding the bladder when levels are high. Norepinephrine prevents low blood pressure. Low levels of norepinephrine have been tied to depression and ADHD. So we can see how we need to reach homeostasis with norepinephrine because it has dramatic effects throughout the body. Metabolic issues can prevent it from being produced or prevent it’s break down. So if we have high or low levels we must address metabolic issues especially phenylketonuria.
Norepinephrine helps protect from sepsis.
Low norepinephrine has been linked to depression, impaired thinking, physical weakness, chronic fatigue syndrome, and fibromaylgia. High norepinephrine has been linked to increased attention, increased awareness, anxiety, restlessness, paranoia, increased heart rate, hypertension, reduced sensitivity to pain, ADHD, depression and difficulty digesting foods and difficulty urinating. There are ways discussed in this article to reduce or raise levels. Though the effects it has is incorrect in this article. Many sites state these things but when I read the research the effects I mentioned above is what the research has shown. So they may be correct on how to lover or raise levels but many sites are incorrect on the effects of norepinephrine.
Tryptophan and tyrosine are used to produce norepinephrine. I used this when my myocarditis was at it’s worse and I had severe POTS.
Low norepinephrine increases risk of dying from sepsis.
This is where those with interstitial cystitis would not benefit from this because of the effects it has on blocking the ability to void the bladder.
Endotoxins cause BH4 to upregualte to protect the brain. This can result in high sulfite levels in the body which can cause problems.
Hawthorne leaves and fruit have many healing abilities and have been shown to help with endotoxemia.