Things that can go wrong in the gut and how you may be able to correct them.

This is not medical advice I am posting this for educational and informational purposes.

 

Always remember homeostasis is the goal.

This is not finished but I need to work on other things and I figure this will give people a good foundation to research and build on.

Lipopolysaccharide (LPS) is usually used when referring to pathogens. Our commensal microbes produce LPS which our body uses to identify them. Normally they are not harmful to the body and some of the other commensal consume LPS keeping levels down. But a loss of those commensal or leaky gut can cause LPS to enter our blood streams which can lead to sepsis so it is very important to protect and maintain the health of our guts.

If we develop leaky gut and do not correct it toxins like mercury that can be in our food and usually will get excreted can now easily enter the blood stream and a person may develop high levels of mercury, cadmium or other toxins in the body.

If you have leaky gut oxalates that usually get excreted can enter the body. It is very important to heal the gut because oxalates are very damaging to the body. Calcium will bond with oxalates preventing them from being absorb and is why if a person is lactose intolerant they need to work on correcting it because milk with meals would help prevent that. Some calcium supplements are not good for you so if you decide to take that route make sure you do your research. Once oxalates build up in your body it prevents the gut from healing so it is very important to reduce oxalate levels. I have posted on reducing oxalates.

There are 2 components to the intestinal barrier. Intrinsic barrier and extrinsic barrier.

Intrinsic barrier is composed of the epithelial cells lining the digestive tube and tight junctions that tie them together.

Our gut bacteria maintain the health of our gut but damage to our gut can inhibit FUT2 production. Our gut microbiome cannot get established if we are deficient in FUT2. Lactobacillus Casei increases FUT2 production by inducing ERK/JNK. Inducing ERK/JNK stimulates FUT2. Nitric Oxide induces ERK/JNK, arginine rasises NO levels. Hypoxia induces ERK/JNK. Interleukin 10 inhibits FUT2 so a person may want to be cautious when taking probiotics that stimulate IL-10. Lactobacillus species of microbiotia stimulate IL-22 especially L Johnsii. IL-22 stimulates FUT2 secretion.

Extrinsic barrier consist of secretions and other other influences like microbes that influences the epithelial layer but are not physically part of the epithelium cells and maintain their barrier function.

Intrinsic Intestinal Barrier.

The gut is lined by sheets of epithelial cells that define the structure of the mucosa they are tied together by tight junctions, which paracellular spaces and thereby establishing the basic gastrointestinal barrier. Paracellular spaces are were nutrients are transported into the blood stream and toxins can be transported to the intestines for removal. Toxins and microbes that are able to breach this barrier have unimpeded access to the circulatory system. The tight junction layer and the mucus membrane for the most part prevents this from happening when healthy. Some cells in the epithelial are not effected by acid but others do not have the protection so count on the mucus membrane to protect them.

Extrinsic Barrier

Mucus that coats the entire epithelium. Hormones and cytokines that regulate the function of our digestive system and maintain digestive health. Our gut microbiome are a part of the extrinsic barrier. They reside in the mucus membrane.

Tight junctions encircle the epithelial cells and are an important part of the intrinsic layer. Their permeability is regulated by zonulin.

Tight junction controls the equilibrium between tolerance and immunity to non-self antigens. It is involved in macromolecular transport and tolerance and immune balance. If the tight junction layer becomes too porous a person may develop autoimmunity and their bodies immune system will turn on the body and start causing autoimmune disorders. A person will develop food allergies and food intolerances. The longer this goes without being addressed the more a persons health will decline. They will develop many metabolic, genetic and immune dysfunctions. Many things can damage this vaccines have been shown to raise B cell levels which causes the tight junction layer to become more porous. BT Toxins in GMOs have been shown to cause the body to react in a way that the tight junction layer becomes more porous. Many farm chemical cause it to become more porous especially glyphosate and glufonisate cause it to become more porous. Stress and trauma can also cause the tight junction layer to become more porous.

Zonulin is the only intercellular modulator of the tight junctions. If zonulin becomes over expressed the gut becomes more porous leading to leaky gut. It is involved in the transport of macromolecules and in balance between tolerance and immune response balance. If zonulin becomes deregulated it can cause inflammatory bowel, anemia, systematic inflammation, red sore areas on the skin known as Sweet’s syndrome that can eventually develop into blisters that eventually turn ulcerative which is known as Pyoderma Gangrenosum. They can develop swelling and sores in the mouth. The eyes can become red sore and inflamed. This condition is called sceritis it can lead to uveitis which effects the iris and can lead to blindness. Bones may thin and become brittle. Oxalates will develop causing stone formation this can also effect the liver. Not only can it cause endogenous oxalates to be produced but now oxalates consumed in our foods that are normally excreted can readily enter the body. Gall stones may form because bile production and pancreatic enzymes become inhibited and a person can develop chronic diarrhea, constipation or alternate between the two.

When the bile is inhibited it is called Primary Schlerosing Cholangitis. From food particles and toxins entering the blood stream a person could start having excessive blood clotting. A person will start developing nutrient deficiencies from being unable to absorb and break down nutrients properly. A person will eventually develop high histamines if this continues they may develop asthma, they can start developing sarcoidosis throughout the body. Mast Cells can start to degranulate leading to mastocytosis or mast cell activation syndrome. This effects our immune system as you will see below. It can lead to diabetes, heart disease and many other chronic illnesses. It can also lead to obesity or anorexia depending on how the person has been effected.

In order to restore zonulin levels to normal the genetic, metabolic, oxidative stress, changes in ph for example if you have developed acidosis or alkalosis it will have to be addressed along with infections that come along with our immune system being disabled. I have posted on most of those issues and correcting them. There are three isoforms of zonulin. ZO- 1 , ZO-2 and ZO-3.

When we get an infection it is a sign we are lacking a nutrient or gut microbe that protects us. The infection produces lipopolysaccharide (LPS) which stimulates zonulin making our guts more porous. Also antibiotics can kill the butyrate producing gut bacteria which makes our gut more porous. Butyrate keeps many things at homeostasis. We cannot restore normal zonulin levels if we do not replace the butyrate producing bacteria and feed them with fiber, oligosaccharides, galactosaccharides, and fructooligosaccharides. The lower the diversity of our gut microbes the higher our zonulin levels will be showing that our digestive system needs feedback from a variety of microbes to function properly.

The fun part of all of this is they will tell you all this in in your head until you are so ill it will take months or years to heal. In the mean time they will still continue to treat the symptoms instead of the cause. It is a common theme with allopathic medicine. I have seen this with naturopathic also but for the most part naturopaths treat the cause and not the symptoms.

Things that can reduce zonulin is meditating, if you have experienced trauma work very heard to move forward. It is difficult not to look back but constantly looking back causes stress and can increase zonulin. Anger increases zonulin so try to learn to deal with frustration and bad situations in a calm way , the calmer we are the lower our zonulin levels will be.

Replace the butyric acid producing bacteria I listed many microbes that produce it if you search my blog.

Inflammation and immune dis-regulation and can increase zonulin so the microbes that increase T regulatory cells and inflammation will reduce zonulin. If your immune system has been disabled then microbiome that stimulates IL-10 will help restore immune function.

High LPS levels will increase zonulin so we need the gut microbes that reduce LPS. Studies have shown the higher our guts diversity the less ZO-1 is express which prevents leaky gut and inflammation.

Under normal conditions things with gliadin , glutin and lactose will not effect a healthy gut but increase zonulin when the mucus membrane is damaged.

There are many molecules that interact with each other to maintain the Zonulin layer and the tight junction layer.

Occludin plays a role in tight junction maintainence and assembly which is regulated by phosporylation of serine, threonine, and tyrosine risidues. It is important for maintaining TJ stability and function. Loss of occludin can lead to leaky gut, inflammatory bowel, and hyperplasia most likely from the inflammation. Occludin also regulates cell survival or death through the intrinsic system. It is important in receiving and transmitting cell survival signals. Occludin has a strong inhibitory effect on cancer. Loss of Occludin leads to cell death.

If Phosphorylation of tyrosine, threonine and serine residues is inhibited it reduces occludins interaction with zonulin. Dephosphorylation of ser/thr residues and poor phosphorylation of tyr residues causes a reduction in occludins interaction with ZO-1 leading to it’s seperation from the junctional complex and TJ disruption. It also leads to excess ROS production which increases gut permeability. Inflammation reduces occludin levels. Endotoxins also reduce occludin. Another function of occludin is in modulating the TJ response to cytokines to protect and heal the tight junction. Occludin plays an active role in cellular location of caveolin-1. Caveolin-1 is required for cytokine induced TJ barrier changes, where it is required for TJ remodeling. So addressing endotoxins, high B cell or T cell levels and reducing inflammation is very important for preserving occludin. Many of our commensals that increase T regulatory cells balance our immune system which would restore proper T and B cell levels. Many of our commensal microbes reduce inflammation and reduce LPS (endotoxins). I have posted on my blog which of those accomplish these things. TNF-a is involved in caveiolinn-1 mediated internalization of occludin which increases occludin, alleviating cytokine induced gut permeability. This can be induced by TNF-a which is an inflammatory cytokine.

Mucous Membrane

The mucus membrane is thin in most inflammatory bowel diseases but is thick in Chron’s disease which I have not researched much on. Inflammtion usually causes the globin which are the mucin secreting cells to become depleted but for some reason this does not happen in Chron’s disease.

All these genes listed below are negatively effected by leaky gut. It is very important to reduce inflammation and work on getting the gut healed to restore the mucous membrane. Damage to the digestive system and mucus membrane causes many genes to become dis-regulated. MUC2 gene is the major gene responsible for the secretion of gel-forming mucin in the intestinal tract. It coats the endothelial surface protecting it from inflammation,chemicals, damage and infection. There are 20 MUC genes. There are many mucin categories that are enriched with proline, serine, and threonine. They are modified by o-glycosylation that creates oligosaccharides that confer on mucins their individual functions. Mucin is made mostly of fat. Those with inflammatory bowel and ulcerative colitis have low B-oxidation which is needed for the break down and use of fats. Since the mucous membrane is mostly fat this causes it to become dysfunctional. This makes people sensitive to fats and is why it is best if they consume medium chain fatty acids because the body can readily use them. Eggs yolks are a good source of phosphatidylcholine which is what the mucus membrane is mostly made of. Most with inflammatory bowel or colitis are sensitive to lecithin. I used sun flower seed lecithin and I did not react to it and it helped me a lot with my healing. Most other sources of lecithin I had to avoid. There are many studies showing that using sun flower seed as a source of lecithin has been shown to heal the gut. As for Chron’s disease I have a theory I have not had a chance to research but I believe they may be deficient in commensal microbes that digest sialic acid. Many of our commensals need it to thrive. Bacteroides Fragilis, Bacteroides Thetaiotaomicron, Bifidobacterium Bifido, Bifidobacterium Longhum, Bifidobacterium Infantis, Akkermansia Muciniphila all need sialic acid to thrive. Another theory I have about Chron’s that I have not gotten to research is they may have an overgrowth of those and that inflammation or LPS is stimulating the production of excessive sialic acid causing and overgrowth of those microbes.

Phospholipase A2 activity is higher in those with inflammatory bowel and colitis.

If a person is having trouble with methyl donors they will not produce enough phosphatidylcholine because methyl groups are used in the process of producing phosphatidylcholine for the mucous membrane. So combine that with the low B-oxidation and you see why it can be so difficult to heal. Disulfide bridges are also a component of phosphatidylcholine showing the importance of addressing things that can impair sulfation.

Phospholipase A2 is high in those with inflammatory bowel and colitis. Phospholipase is stimulated by inflammation. It is a mixture between inflammation and substance P and is why those with leaky gut have high substance P levels. When substance P levels get high the skin will have a burning sensation especially in the scalp and it may go down the spine. Substance P levels increase at night so the symptoms will worsen at night.

Annexin also known as lipocortin keeps PLA2 in check. Adrenal hormones increase Annexin but in many people with inflammatory bowel the adrenals become depleted from being over activated and they develop Addison’s disease which is a deficiency of adrenal hormones. Adaptogens help alleviate this which would help restore annexin levels. Annexin also helps repair our immune system. If annexin gets low the blood brain barrier becomes porous because it helps maintain the blood brain barrier. Annexin is also involved in protecting the brain from infection. It is very important to support the adrenals with the proper nutrients and to reduce inflammation so the adrenals can recover. Oddly Okadaic Acid a toxin found in shell fish increases annexin. This is something a person would definitely need an experienced medical professional to do. IL-6 increases annexin expression. To restore normal cortisol levels stress management is very important. Increased stress depletes cortisol. Getting rest is important, even if you cannot sleep just laying and resting can help increase cortisol. Avoid, caffeine, alcohol and smoking. Our mucosal layer will take up fats and integrate them to strengthen itself. Omega 3 oils, cod liver oil, nuts, and avocados help increase cortisol. Avoid processed sugar it depletes cortisol levels. Citrus fruits especially grape fruit increases cortisol but grape fruit inhibits certain cytochrome P450 enzymes so should not be eaten too often. Eat foods high in melatonin or take melatonin supplements at night which will increase cortisol. Non processed carbohydrates help increase melatonin. Magnesium is important for maintaining proper cortisol levels. Reducing inflammation can help normalize cortisol levels. Earth grounding and getting sunlight help to normalize cortisol levels. I still laugh when I mention earth grounding because I thought how could something so simple have so many health benefits. So I was determined to find research to show those earth grounders were crazy instead it was I who was crazy and the earth grounders are correct. I could find no research to prove them wrong but plenty of research showing the many health benefits of earth grounding.

We have to keep in mind goblet cells build our mucus membrane and when inhibited by inflammation, toxins or even damage to our digestive system our ability to produce mucin is reduced or inhibited. Bismuth even though it is a metal, is for the most part none toxic it takes very high doses for a very long time to reach toxic levels. It helps the gut heal. It kills many pathogens and can cause commensals that have turned pathogenic to go back to commensal. Mucilage helps protect the gut so it can heal. I have posted on reducing inflammation if you search my blog. Oatmeal is high in mucilage but you must get organic because they use glyphosate and glufonisate on grains and beans to dry them and those destroy our gut and kill our gut microbes. Three very good sources of mucilage is okra, arrow root and oatmeal. Make sure the oatmeal is organic. Most non organic oatmeal has farm chemicals that destroy the gut.

Here is an in depth article on mucus membranes.

https://www.readkong.com/page/the-interaction-of-the-gut-microbiota-with-the-mucus-1350713?p=1

Sialylation has been found to be increased in those with inflammatory bowel dieseases. Excessive sialylation increases inflammation. IL-10 inhibits Sialylation. Their are probiotics that increase IL-10 but IL-10 inhibits FUT2. So an oligosaccharide,galactosaccharride and fructosaccharide would probably have to be supplemented with it. I suspect the body is trying to increase the commensals that rely on the nutrients produced by sialylation and they have been depleted by antibiotics. Some commensals rely on FUT2 but others rely on sialylatin. Some do not produce the enzymes to break down sialic acid and rely on other commensals to produce it. A deficiency in either of them is probably what is causing the high sialylation. The body is trying to feed them. It is not getting the feedback from those commensals.

The bacteria this would help thrive are B Fragilis, B Theaiotaomicron, B Bifidum, B Longhum, B Infantis and A Muciniphila. I believe those with inflammatory bowel especially those with Chron’s will be deficient in those because those with Chron’s have a thicker mucous membrane.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747158/

The increased inflammation and infection caused by the above mentioned things results in an accumulation of ROS which can lead to further damage and it disturbs mitochondria function and autophagy. Once the mucus membrane has been damaged all the things mentioned below lose their protection and become dysfunctional. It may be necessary to take mucilage and bismuth to help protect them and restore their function. Once the mucus membrane breaks down it creates a cycle that has to be broken because the mucus membrane needs the things mentioned below to function properly and they need the mucus membrane to protect them and to function properly. Dysfunction in either of them from infection or toxins can start a cycle that has to be broken to heal. Our gut microbiome cannot become established without the mucus membrane because it also protects them. Our mucus membrane is a mediator between host and microbiota interactions. Decreased mucus membrane thickness causes a change in our gut microbiome and makes us more prone to infections.

This is where addressing sulfation issues, methyl group issues and issues with thiols comes in because the production of mucin requires all of those to be functioning. I have posted previously on how to deal with those issues. For the production of the oligosaccharides the endoplasmic reticulum and stem cell are required.

L-cysteine, L-arganine, L-threonine, L-serine, and L-cysteine increase mucin production in the digestive system and have been shown to promote gut microbiome homeostasis. Citrus fiber increases mucin especially the white part of the fruit. Pectin stimulates Goblet cell formation which secretes mucin. The microbiome that help restore gut health are Bifidobacterium Bifido, Bifidobacterium Breve, Bifidobacterium Lactis, Enterococcus Faecium, Lactobacillus Acidophilus, Lactococcus Lactis

For those who do not have glutamate issues bone broth heals the gut very quickly. Those who have high levels of sulfur digesting bacteria will have problems with the consumption of bone broth also.

The small intestine is the portal for the absorption of most nutrients in the body. The chyme which is the digested food that has exited the stomach enters the small intestine pancreatic enzymes and bile is secreted. This breaks the food down and if functioning properly it will be almost liquid when it enters the lower intestinal tract. Bicarbonate is also added by the body to reduce the acidity before it enters the large intestine. The enteric nervous system and gastrointestinal hormones regulate this process and the intestinal motility. Intestinal dysbiosis can cause incorrect communication or inhibited communication which leads to inflammation, intestinal damage and it could lead to a loss of the ability to produce bile and digestive enzymes. To restore proper function we must reduce the microbe causing the problem. Those who have high sulfur digesting bacteria will develop high hydrogen sulfide levels which interferes with sulfation and can interfere with the proper function of the CBS and BH4 pathways. This can lead to high sulfide levels in the body. BH4 levels will become low causing ammonia to build up when protein is consumed. The high ammonia levels will cause some commensals to go into protection mode and they will become pathogenic. Candida and H Pylori are two examples. To make matters worse they also start producing ammonia to protect themselves from the acidic environment. The digestive tract is supposed to be acidic. Ammonia alkalizes it this also makes us more prone to infections because the commensal microbes that protect us cannot survive in an alkaline environment. When we lose our commensal bacteria we lose proper immune function and our zonulin levels increase and our gut becomes more porous leaving things enter the blood stream that could not normally enter. Inflammation and oxalates can inhibit bile flow causing it to back up, when this happens the gallbladder is effected. Instead of addressing the problem modern medicine gets rid of the symptom by removing the gallbladder thus the illness continues to worsen and taking the gallbadder out can contribute to it’s progression.

If bile becomes inhibited it inhibits the vitamin D receptor further inhibiting bile production and adding to the problem because cholesterol production and conversion becomes inhibited. This will make bile become sludgy leading to low bile flow which will increase estrogen levels and cause high unbound copper levels in the blood. Bitter herbs increase bile flow but the vitamin D receptor has to be addressed along with balancing the microbiome in the gut and healing the intestinal tract.

This is why I often times recommend grape seed extract and bacopa to people. It prevents thrombosis. Inflammation because endotoxins can cause thrombosis. Grape seed extract and bacopa reduce inflammation and prevent thrombosis. If thrombosis occurs in the portal vein it will effect the liver, pancrease, and digestive system. This causes pain in the stomach, bloating, inflammation, pancreatic pain, pain in the gallbladder. This can lead to death. Bile flow will become inhibited speeding up the progression of portal vein thrombosis. Those with hepatitis need to use hawthorne or something else. Resveratrol activates hepatitis.

portal vein thrombosis

gastrointestinal symptoms (ex: abdominal pain, nausea, vomiting, and diarrhea), fever and constitutional symptoms (ex: fatigue, malaise, and anorexia/weight loss) [3]. We can also find hepatomegaly with elevated liver enzymes and jaundice [3], when associated with liver abscess or cholangitis [2]. Laboratory tests usually demonstrate elevated markers of inflammation [2]

https://www.journalmc.org/index.php/JMC/article/view/3050/2378

If not addressed in time it can lead to portal hypertension. This results in brain swelling, abdominal swelling . Confusion, anemia and low white blood cell count.

https://my.clevelandclinic.org/health/diseases/4912-portal-hypertension

Autophagy is very important in maintaining health and we need a proper balance. It can be disrupted if we have intestinal damage. If autophagy is inhibited we become prone to infection and mitochondrial dysfunction. Autophagy is the housekeeper of our cells. One common theme you will see is inflammation and shows the importance of reducing inflammation. Which could involve diet changes, addressing metabolic issues, reducing toxins and infections. Addressing detox issues and detoxing in an appropriate manor for the individual. Addressing gene issues which could be caused by any number of things including a lack of the microbe in the gut that may modulate that genes function.

The mucus membrane in our digestive system protects us from infection, physical and chemical harm. Our commensal bacteria cannot exist without it. It is very important to restore our mucus membrane when damaged in order to restore intestinal homeostasis. Many genes mentioned below are effected when it is damaged because it causes a dysfunction in them. Autophagy is very important for the maintenance or proper gene function.

Paneth cells are located within our mucus membranes and provide immunity, prevent damage to the digestive system and is involved with nutrient absorption. Loss of our mucus membrane from loss of microbiotia, drugs or farm chemicals found in our food can destroy our mucus membrane. This causes damage to the digestive system which can further inhibit the bodies ability to produce mucin. This makes us more susceptible to infection. Paneth cells stimulate the production of AMPs which fight infection and modulate commensal microbiome and innate immunity. A list of AMPs are defensin-like human lyzosome, defensin (HD)-5 and 6, lyzosome, regenerating islet derived gamma(Reg3y), and phospholipase A2 group 2A(sPLA2) as well as inflammatory cytokines such as Transforming Tumor Necrosis Factor A (TNF-a), Growth Factor B1 (TGF-B1), and Postaglandin E2. AMPs are sensitive to ER stress which I discuss below.

Autophagy protects against infection by producing Antimicrobial Peptides and degrading organelles that break down misfolded proteins and AMPs break down pathogens. This can ease the over activated inflammatory response and over active immune response. Some AMPs are defensin and cathelicidens which protect against microbes.

Intestinal Epithelial Cells. (IECs) – form a physical and chemical barrier involved in inflammatory response and immune reaction. IECs work as an interface between the quantitive microbial ecosystem in the intestinal lumen. Lumen is inside space or opening in a tubular structure.

There are 6 types of IECs

Goblet Cells which secrete mucin to build up the mucin barrier.

Enteroendocrine cells which produce gastrointestinal hormones that communicate with the nervous system, the brain and organs throughout the body. They respond to nutrients within the intestines. Helps restore intestinal tissue.

Absorptive Enterocytes – epithelial cells in small intestine. They are involved in nutrient absorption, absorption of conjugated bile acid, lipid uptake, Issues with Absorptive Enerocytes can inhibit glucose absorption and can result in lactose intolerance and many other food intolerances. It can also result in an electrolyte imbalance. Enterocytes secrete a series of chemokines and cytokines which regulate immune responses of subjugant mucosal. (Mucosal control)

Tuft Cells – brush cells which are chemosensory cells in the intestinal epithelial lining. Tuft refers to microvilli projecting from the cells. They increase during parasite infection. They are the sole source of Interleuken 25 which induces NF-kB activation which helps protect from infection. High levels of IL-25 raises eosinophils which causes inflammation and is suspected of causing inflammatory bowel diseases. Eosinophils have been shown to kill many types of cancer cells. Infection also stimulates Tuft Cell to produce IL-25. They are increased through a T cell response through a type of lymphatic tissue. Tuft cell also secret endogenous opioids. Eosinophils cause asthma, cardiovascular disease and can even cause headaches, mood swings and brain fog.

Microfold Villous Cells – are found in the Gut-associated Lymphoid Tissue (GALT) of the Peyers Patches in the small intestine and the Mucus-associated Lymphoid Tissue (MALT). M Cells initiates mucosal immunity. They allow the transport of microbes and across the epithelial cell layer. From the gut lumen to the lamina propria. M cells contain Epidermal growth factor which acts as a sensor to stimulate repair through the intestines including the mucus membrane , tight junction protein layer and it stimulates goblet cell differentiation and many other things in the colon.

Endoplasmic Reticulum are organelles within our cells and plays a major role in the production of proteins and lipids. So this is where our enzymes , hormones and even our detox enzymes are produced.

Endoplasmic Reticulum Stress Unfolded Protein Response (UPR) is activated in response to unfolded or misfolded proteins in the endoplasmic reticulum. It stops the production of unfolded or misfolded proteins it is the quality control mechanism. It will stop production and start cleaning the bad proteins out. If it continues for too long then it will induce apoptosis which is cell death. If overactivated which vaccines and many farm chemicals can cause to happen it can lead to prion disease. It plays a valuable role in intestinal endoplasmic reticulum survival and function. Dysfunction of endoplasmic reticulum can result from genes that have been effected from infection, toxins, or even stress can result in abnormal UPR function. This is referred to as Endoplasmic reticulum stress.

ER stress activates three kinds of proteins which reside in the ER membrane to detect UPR in ER Lumen and resolve them. Autophagy reduces ER stress.

inositol-rquiring membrane kinase endonuclease1 (IRE1) via a really long pathway that I am certain you do not want me to type out. Issues with the genes involved in these mediators in intestinal endothelial cells will change the histological structure of the intestinal epithelium.

XBP1- inhibition will exhibit impaired Paneth Cells, which leads to dysbiosis and spontaneous intestinal inflammation which may induce activation of NF-kB pathway which can lead to inflammation, anxiety, chronic depression, insulin and leptin resistance, it increases risk of cardiovascular disease and high TH17 levels which can lead to psoriasis or lupus, Many who have intersitial cystitis have high TH17 levels. It can cause bone lose and Alzheimers. On the other end of the scale not enough NF-kB can produce many health problems. Like lower cognitive function, inhibited ability to heal, inhibited nerve growth and brain plasticity. This is a good article covering it in more detail. https://www.selfhacked.com/blog/nuclear-factor-kappa-b/

The second gene that can increase risk of inflammatory bowel disease is oromucoid-like3 (ORMDL3). Over expression can lead to immune/inflammatory diseases. It has been linked to childhood asthma. Over expression causes inhibited calcium buffering capacity of the mitochondria. This can disrupt endocytosis, enzyme control , cell growth and proliferation and cell apoptosis. ORMDL3 takes part in protein folding and in regulating UPR. It is believed ERs induced inflammation in paneth cells may disturb ORMDL3 levels leading to inflammation.

TREM1 (Triggering Receptor Expressed On Myeloid Cells-1) inhibits autophagy and increases ERs stress levels. This has been shown to increase the severity of inflammatory bowel diseases. Defective autophagy in the endoplasmic reticulum can predispose someone to inflammatory bowel diseases form a decreased clearance of IRE1 during ERs. High IRE1 levels impairs insulin signaling this can lead to many metabolic diseases. TREM1 can either increase inflammation or decrease it. During infection TREM1 increases inflammation. TREM1 also interacts with other inflammatory pathways which can also result in TREM1 increasing inflammation. TREM1 is high during septic shock. Sustained increased levels of TREM1 can lead to inflammatory bowel disease, cardiovascular disease and atherosclerosis. TREM1 is needed to help clear infection. Unfortunately when an infection that contains OspA protein that are difficult for the body to clear like HIV and Borellia (Lyme Disease) it can cause TREM1 levels to remain high. This is why it is very important to work on reducing inflammation and address infection. Most infectious diseases there are no test for and the test they do have has a high failure rate at detecting the microbe responsible for the illness. But the body and what genes are effected and cytokines present can indicate when there is an infectious agent present. The more difficult infections can be killed but it takes a multilevel approach because most that carry the OspA take multiple forms and have to be addressed differently for each form it has taken.

Inflammatory bowel disease have been shown to have a dis-regulation of T Cell which can be induced by toxins, drugs, vaccine injury, farm chemical or processed foods.

Autophagy is a conserved lysosome-dependent catabolic process involved in degrading and recycling aggregates as well as damaged organelles. Enhancement of autophagy promotes the survival of various cells including intestinal endothelial cells, and nuetrophils by protecting them from microbial toxins. A disturbance in autophagy could disturb the function of intestinal endothelial cells and influence inflammatory response, immune response, ROS levels and endoplasmic reticulum stress. This can lead to inflammatory bowel diseases. Autophagy plays a vital role in alleviating of intestinal inflammtion, degredation of damage associated molecular patterns (DAMPS), which can help prevent inflammatory bowel diseases. PAMPs refer to various kinds of endogenous materials produced by stress, impaired or dying cells covering DNA, RNA, ATP, histones, hyaluronan, uric acid, heparin sulfate, the S100A calgranulins, IL-1, HSP, and chromatin-associated high motility box1(HMGB1).

Basal autopaghy occurs in nearly every cell to maintain homeostasis of the ammino acid pools. There are three types of autophagy.

Macropahy – targets material such as cytoplasmic components or invasive bactria which are surrounded by a double-membrane bound autophagosome.

Autophagosome when combined with lysosomechanges into a single-layer membrane autolysome with a strong degradative and digestive ability.

Microautophagy – during the process of microautophagy lysosomal/vacuolar membranes invaginate (fold in on itself) to engulf intracellular components via a non-selective degradative mechanism.

Chaperone-mediated autophagy transports organelles and proteins into lysosomes only with the assistance of chaperones which are located in lysosomal lumen. Chaperons are proteins that assist in convalent folding or unfolding and the assembly or disassembly of other macromolecular structures. They assist in the assembly of nucleosomes which are basic units of DNA.

Two steps of Autophagy.

The first step of autophagy cup-shaped double membrane phagophores are shaped in the cytoplasma of the cell, and then misfolded proteins, damaged organelles or bacteria are engulfed to become sperical double membraned autophagosomes. Autophagosomes are usually considered to be produced from the nucleation and membrane expansion of phagophores.

During the second step autophgosomes fuse with lysosomes and endosomes to form a single-lipid layer autolysome, which is regard as basal units for degradation and digestion. Autophagy process is induced by the detection of various specific cues such as starvation or invasion by pathogens.

Two proteins are known to participate in autophagy which include Mammaian Target of Rapamycin (mTOR) as an inhibitor and adenosine monophosphate activated protein kinase as an indicator. mTOR is often activated by lower levels of Adenosine Triphosphate (ATP) caused by nutrient sufficiency or several growth factor stimulations. mTORC1 inhibits autophagy in the presence of nutrients. mTORC1 regulates glycolysis, lipid biosynthesis, and the pentose phosphate pathway has been found to be under the control of mTORC1. mTORC1 mediates upregulation of SREBP-1 activity which is necessary for lipid biogenesis. mTORC1 increases mitochondrial DNA copy number and as well as encoding many genes involved in oxidative metablolism. It has been found that mTORC1 promotes transcriptional activity of PPARy coactivator (PCG-1a) which is usually low in those who have inflammatory bowel diseases. This leads to the inability to break down fats and cholesterol causing many health problems because lipids are needed by almost all cells of the body especially the digestive system to maintain proper function and health. Ironically mTORC1 inhibition leads to longer lifespan. mTORC1 inhibits autophagy. mTORC1 increases NRF2 activity the master regulator of the antioxidant system.

Excess mTORC1 activation can cause endoplasmic reticulum stress and excess ROS production.

Low ATP levels inhibits mTORC1. Inhibiting mTORC1 increases glucose uptake. Hypoxia (oxygen deprivation) inhibit mTORC1. Amino Acid deprivation can inhibit the citric acid cycle (TCA cycle) this also inhibits mTORC1. The body inhibits mTORC1 when it senses DNA damage. Autophagy reactivates mTORC1 whose activity then promotes the replacement of lysosomes consumed during autophagy.

Symptoms of excess mTORC1 . Since there is no information on what excess mTORC1 does I will have list the symptoms of inhibited autophagy and high ROS levels since those are issues caused by high mTORC1 levels.

Symptoms of inhibited autophagy. Nuerological problem , inhibited autophagy can lead to inflammation in the brain, mental illness. Mitochondrial dysfunction, decreased antioxidant function which can lead to high levels of ROS. Pancreatic inflammation. Fat accumulation throughout the body and can lead to fatty liver disease. Issues with lysosomal storage, diabetes and sickle cell anemia. Frequent illness from infectious agents.

Symptoms of high ROS. ROS is needed for redox signaling but becomes damaging if levels get too high. High levels of ROS cause inflammation. Leaky gut and can cause a leaky blood brain barrier. This also can lead to nuerological damage and brain inflammation causing mental illness. Can cause liver damage resulting in a hepatic liver. Fatigue from reduced energy levels. Mitochondrial dysfunction which can lead to MS. Here is a link to a good article on oxidative stress.

https://www.selfhacked.com/blog/oxidative-stress-101/

Things that stimulate mTORC1. Resistance training, amino acid L-Luecine, Beta Hydroxy Beta-methylbutyric acid which is a precursor of butyric acid. High intake of Iron stimulates mTORC1.

Inhibitors of mTORC1 are green tea, resveratrol, curcumin, caffeine and alcohol. Iron deficiency inhibits mTORC1. Green tea can damage the liver if taken for too long and curcumin chelates iron so can make a person anemic if consumed too long.

VDR

Vitamin D receptor (VDR) mediates the activities of vitamin D3 which is the activated form of vitamin D. A deficiency can effect our digestive system in many ways. The VDR is involved in regulating 33% of the genes in the body so problems with it can effect many things. VDR and Retinoid X receptor interact to with each other and can activate each other so issues with either one can effect vitamin D homeostasis. Inhibited VDR effects calcium homeostasis, electrolyte balance, and blood pressure.

Vitamin D3 acts as a hormone a hormone and helps regulate innate and adaptive immune responses. Those with low vitamin D levels or inhibited VDR receptor are prone to infection with Mycoplasma Tuberculosis. VDR is involved in producing the antimicrobial peptide/IL-37, defensin beta B, CLDN2 encoding claudin 2 and ATG16L1 related autophagy which protects us from inefection.

The VDR receptor is involved in gut microbiome balance and autophagy. Autophagy is the house keeper of our cells it helps clean them out, protect them from infection and helps to prevent misfolded proteins. Inhibited vitamin D receptor can cause inhibited bile flow and a decrease in LDL and increase in HDL. The reduced LDL causes bile to become sludgy which leads to biliary issues and gallbladder problems and can result in gall stones and biliary blockage.

When the VDR receptor is inhibited or there is a vitamin D deficiency we can develop inflammatory bowel diseases. IKBa is an inhibitor of pro-inflammatory NF-kB.

VDR inhibition or vitamin D deficiency alters the composition of intestinal microbiome. Butyrate producing bacteria become less numerous. Butyrate increases expression of VDR so a deficiency in Butyrate would further add to the inhibition of the VDR receptor. Butyrate also suppresses intestinal inflammation and enhances AMPs. AMPs help protect us from infection.

Toxins, mold toxins, infection and a lack of nutrients can inhibit the vitamin D receptor. High levels of vitamin D3 indicates the body has recognized an infection and is trying to fight it.

Farm chemicals especially glyphosate and glufonisate inhibit the vitamin D receptor. Many toxins found in processed food can also inhibit the vitamin D receptor.

Symptoms of inhibited VDR.

If the VDR is inhibited a person may experience problems with methyl donors and low dopamine levels. They may experience frequent infections and be low in GcMAF. Inhibited VDR can cause bone loss, hair loss, brain fog, increased TH17 levels resulting in lupus, psoriasis and/or skin rashes, tooth decay and poor oral health, inflammation throughout the body, can lead to high blood pressure. Low LDL which inhibits bile production resulting in biliary and gall bladder problems and can lead to stone formation. Electrolyte imbalance and iron deficiency. Low dopamine and GABA levels is a result of VDR inhibition. Prolactin level become low when VDR is inhibited. Gut dysbiosis and inflammation in the digestive system. Increased creatine and albumin levels and decreased alkaline phosphatase are symptoms of low vitamin D or inhibited vitamin D receptor. VDR inhibition or vitamin D deficiency can result in mast sell activation syndrome. CYP3a4 an enzyme needed for detoxing xenobiotics and drugs becomes inhibited. Hormonal imbalance is also a result of VDR inhibition. Hashimoto’s syndrome can result from VDR inhibition. Heart disease can be a result of VDR receptor inhibition or vitamin D deficiency. In more severe cases VDR inhibition can lead to liver and kidney disease.

Symptoms of Vitamin D deficiency.

Joint stiffness or pain, back aches, tooth decay, bleeding gums or gum disease, muscle cramps, hair loss, bone loss, weakening of bones, increases risk for cancer, sleep apnea, brain fog, fatigue, depression, leaky gut, excess sweating especially in the head area.

Excess vitamin D can lead to many health problems and can result in loss of bone from a disruption in the mechanisms that control calcium homeostasis. Though it is needed for calcium absorption high doses can have the opposite effects. High levels of vitamin D can lead to oxalate formation. Many studies show anything over 5000 IU a day can lead to oxalate formation and many health problems.The recommended daily allowance of vitamin D is 600 IU. It is best to get vitamin D from food sources. Exposure to sunlight, far infrared, halogen lights can increase the bodies production of vitamin D. Short term raised levels have been found to be beneficial but long term raised vitamin D levels have been found to be harmful to our health. High levels of vitamin D can contribute to the inhibition of the VDR. Excess vitamin D can result in high levels of calcium in the blood resulting in calcium deposits forming in the organs including the lungs.

Sources of vitamin D. Sunlight, halogen lights, far infrared light increases the bodies production of vitamin D. Excess sunlight has been shown to cause high levels of vitamin D and is why life guards have some of the highest rates of kidney stones. Fish oil contains vitamin D. Sardine , salmon and cod liver oil are good sources. I try to make sure the fish is not from contaminated areas. Most sea food is high in vitamin D. Mushrooms and eggs are a good source of vitamin D. Animal liver is another good source of vitamin D. Cestrum Diurnum, Waxy leaf nightshade (solanum glaucophyllum), yellow oat grass (trisetum flavescens) are plant sources of vitamin D. Those plants are so high in vitamin C that they cause calcinosis in grazing animals. Brown and read seaweed are also sources of vitamin D and cholesterol. Mercury found in fish is for the most part only a problem if we have leaky gut. When the gut is intact only about 5% of the toxins like mercury get absorbed that have been consumed and when healthy the body can easily detox that amount unless it is shot directly into the blood stream. I mention this because even though they claim vaccines do not contain mercury some still do.

Things needed for the body to be able to use vitamin D. Vitamin K2, Vitamin A, zinc, sulfur is needed to sulfate vitamin D so sulfation issues need to be addressed. Magnesium increases the bodies response to vitamin D. Boron increases vitamin D in the blood stream. Water is needed, dehydration inhibits many receptors in the body. Silica helps improve the function of many receptors in the body. Sunlight helps to sulfate nutrients. DAO and lysine are also needed to sulfate vitamin D. Boron is touchy, low levels reduce estrogen high levels increases estrogen.

Things that enhance vitamin D receptor activity. Parathyroid hormone, Sirt 1, Dopamine, Omega 3 , Omega 6, Phytoestrogens, Testosterone, Postaglandulins and bile activates VDR. Bitter herbs stimulate bile production. Even if you do not swallow bitter herbs just tasting them stimulates bile production. Resveratrol activates the vitamin D receptor. Querciten enhances vitamin D receptor activity. Curcumin stimulates the vitamin D receptor but if taken for too long it can lead to anemia because it chelates iron from the body. So one may use it at first to help stimulate the VDR receptor but probably should just take maintenance doses to make sure it continues to function. Human Growth Hormone stimulates the vitamin D receptor. Sleep, fasting, and strength training increase HGH.

Things that can inhibit VDR are cortisol/glucocorticoids, high prolactin levels, imbalance in thyroid hormones, TGF-Beta, phosphatonins which regulate phosphate homeostasis, and ubiquitin can inhibit VDR. Many of these things are inhbited by autophagy which would prevent them from inhibiting the VDR receptor. Caffeine can also inhibit the VDR. High TGF-B levels can be an indication of T cell imbalance and/or B cell imblance. Probiotics that reduce inflammatin and increase T regulatory cells should reduce TGF-B. High phosphatonins is a sign of low klotho levels. Exercise increases klotho, Most Acidophilus bacteria and Lactobacillus Lactis increases klotho. Cordyceps mushrooms increase kltoho. PPAR Gamma activators stimulate klothos, Some PPAR gamma activators are berberine, magnolia, and Omega 3s. Those who are obese should not stimulate PPAR gamma because they are usually PPAR gamma dominant. Adaptogenic herbs like suma root and maca root can help normalize adrenal levels. Ubiquitin levels are reduced by autophagy. High prolactin levels can result from toxins in plastic containers used to store food and some farm chemicals found in our food supply. There are also chemicals in processed foods that can cause high prolactin levels. Those who are taking drugs should not use berberine or things that contain it because it inhibits the cytochrome P450 enzymes needed to detox medications.

Fulvic acid and nobiline induce autophagy. We do not want to overstimulate autophagy. Fasting also stimulates autophagy but those who are Type1 diabetics have to be careful fasting can induce ketoacidosis in them. Branch Chain fatty acids can inhibit autophagy. Tumeric, ginger, berberine, gensing, mushrooms and elderberries can stimulate autophagy.

NOD2 – Nucleotidebinding Oligomerization Domaincontaining Protein 2 whew that was a lot. A member of the NLP family which is a group of immune regulating proteins. It is a sensor of muramyl dipeptide which is a constituent of both gram negative and gram positive bacteria. It is found in macropages and paneth cells. When inhibited a-defensin numbers are decreased, lower sensitivity to bacteria infection, and altered immune function from Toll Like Receptors becoming suppressed. This results in the inability to clear bacteria infections from the intestines. Inate and adaptive immunity is impaired. Nod2 induces autophagy through the NOD2 pathway. NOD2 is induced by NLP or bacteria infection, this promotes the delivery of NOD2 which enhances inflammation. Showing that if You have high NOD2 levels you would not want to induce autophagy. NOD2 prevents infection in cells which is mediated by ROS and MAPK pathways. NOD2 altered expression can lead to inflammatory bowel disease. Many cellular proteins interact with NOD2 directly and regulate it’s function positively or negatively. Among these proteins is Erbin. Erbin regulates Erbb2 if Erbin is inhibited Erbb2 levels can go up resulting in cancer growth. Centaurin B1 which I have no idea what it’s function is. Angio-associated migratory protein which is involved in endothelial tube formation and endothelial cell migration. It is involved in angiogenesis. Carbamoyl-phosphate synthase 2 is involved in the production of nucelotides in cells. Mitogen-activated protein 1 which helps down regulate NOD2. Heat shock protein 90 interacts with NOD2. HSP90 is involved in folding , intracellular transport and the degradation and maintenance of proteins. I have post on heat shock proteins like HSP90 and HSP70.

NOD deficiency. NOD2 is involved in maintaining balance between the microbiome and immune response. NOD2 deficiency results in loss of epithelium integrity, and increased susceptibility to intestinal inflammation. NOD2 deficiency can cause dysfunction in intestinal paneth and goblet cells. Deficiency increases IFN-y, and decrease ROS production which protects from infection so we need a balance because excess ROS can damage tissues in the body.

NOD2 upregulation. Vitamin D supplementation has been shown to increase NOD2 which helps to fight infection. Excess NOD2 can lead to rheumatoid arthritis, and systematic inflammation. Excess NOD2 has been linked to cardiovascular disease and pulmonary disease. NOD2 prevents inflammation in the eyes.

NOD2 deficiency causes low TH17 levels, inhibited immunity, and will be more prone to cancer. NOD2 is also involved in the detection and eradication of viruses.

Excess NOD2 causes systematic inflammation and sarcoidosis. Often times it is mistaken for cancer or copd. High NOD2 levels is a sign of infection.

Damage to the mucus membrane and intestinal tissue can cause it’s dis-regulation. This shows the importance of restoring mucus membrane and work on healing the gut.

Atg16L1

Autophagy-Related Protein 16-like Protein 1 – Deficiency in Atg16L1 impairs recruitment of Atg12-Atg-5 complex which impairs the engulfment of pathogens and cellular organelles during the process of autophagic catabolism. Atg16L1 defeciency cause Paneth cell dysfunction and increases inflammation. Atg16L1 causes high leptin and adiponectin levels. A deficiency in Atg16L1 leads to intestinal lesions. Leptin tells the brain we do not need to eat. Leptin increases inflammation in the body. High leptin levels lead to chronic fatigue. Leptin can cause Th1 dominance. Those with high IL-10 levels would want to avoid probiotics that increase IL-10 because leptin increases IL-10. Leptin causes mast cells to become more inflammatory. Leptin causes lower T regulatory cells which keep our immune system at homeostasis. Leptin can cause excess blood clotting (throbosis). Leptin can cause high blood pressure. Leptin increases estrogen levels. Adiponectin is a protein hormone involved in glucose levels and fatty acid breakdown. High adiponectin levels causes a loss of appetite it causes weight loss and works synergistically with leptin. Adiponecton decreases gluconeogenesis. It increases B-oxidation of fats. It protects against endothelial dysfunction. It increases insulin sensitivity. So you can see the importance of Atg16L1 homeostasis.

Mir223 restores autophagy and Atg16L1 homeostasis. Mir233 downregulates inflammation. Mir233 is reduced in sepsis. Mir233 increase HDL cholesterol levels. But Mir233 is upregulated in inflammatory bowel diseases. Increasing Claudin-8 inhibits Mir233 inflammatory effects.

ROS (Reactive Oxygen Species)

ROS or Reactive Oxygen Species modulates cellular function under normal conditions. ROS is produced during the process of oxidative phosphorylation and can be handled by instracellular antioxidants. Injury, toxins , vaccine injury, infection, and stress can cause an over production of ROS which can exceed the generation of antioxidants leading to oxidative stress which can cause a lot of damage throughout the body. It causes inflammation, cell damage and even cell death. When the mitochondria become dysfunctional this can cause a rearrangement of the cytoskeleton which is framework of the plasma membrane and effects the balance between kinases, and phosphatases which promotes the ability of microorganisms to enter the cell and contributes to many inflammatory diseases. Excess ROS increases the permeability of intestinal epithelial. When levels of ROS are normal it will induce autophagy and microphagy which reduces inflammation. Reducing ROS levels too low can have the opposite effect because it would prevent it from inducing autophagy and we would lose the protection it gives us from infection.

Antioxidants can reduce oxidative stress but when homeostasis is achieved a person should only take maintenance doses. Over use of antioxidants can promote cancer by protecting it from apoptosis it also increases our risk of infection by reducing ROS levels too low.

Xenophagy

Xenophagy is the clearance of pathogens regulated by autophagy. Reduces Xenophagy leads to alterations of intestinal microbiota. This leads to a higher rate of infection. The microbiotia induce xenophagy in basal paneth cells which is induced by INF-y to maintain intestinal integrity. This impairs sensing of intracellular micro organisms in the intestinal endothelial cells and contributes to the progression of inflammatory bowel disease. Showing the importance on healing the intestinal tract so that the mucus membrane can be restored. Prebiotic fiber and the tryptophan metabolizing gut microbiota increases IFN-y. The commensal strains of E Coli increases IFN-y. Lactobacillus Gasseri increases IFN-y. Bacteroides Fragilis increases IFN-y and has been found to protect from many types of infections. Butyric Acid must be present to maintain IFN-y homeostasis. So it would also be a good idea to make sure the butyrate producing microbes are established.

IRGM (Immunity Related GTPase Family M protein) – is involved in killing of bacteria, vacuolar trafficking and acidification, it is also involved in autophagy. It is involved in fighting mycoplasmas. Damage to the digestive tract can impair it’s function which wold make you susceptible to mycoplasma infection. Inflammation inhibits IRGM. Our digestive tract needs to be acidic. If it becomes to alkaline then it creates an environment that promotes infection and dysbiosis and we lose our commensal microbiota.

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Leaky Gut, Oxalates and more supplement information.

This is not medical advice and should not be taken as such. I am posting this for educational and informational purposes.

Avoid GMOs they cause leaky gut and gut dysbiosis. If you do not know about them read my post on them. They and the chemicals used on them cause oxalates which I mention later in this article. They kill our good gut microbes. This is a list of gut microbiota and what conditions they help with.

Mucilage every few hours helps a lot with leaky gut. When you have leaky gut it causes high oxalate levels. This causes a cycle that is hard to break because oxalates prevent the gut from healing. Mucilage can help heal the gut breaking the cycle. Mucilage helped me the most with healing my gut.

Things that are high in mucilage are Okra, organic Oatmeal, Aloe Vera I found the liquid gel worked the best dried aloe vera seemed ineffective. Besella Alba known as Malabar Spinach, Irish moss but you have to watch consuming it, it has a cannabinoid that reduces pain but has side effects if you consume too much. Most plants in the mallow family are very high in mucilage and have very good healing properties. Most plants in the dioscera family are high in mucilage especially the chinese wild yam. Fenugreek is high in mucilage. Flax seeds are high mucilage but if you have leaky gut they should be ground up to prevent other heath issues. Most seaweeds are high in mucilage. Licorice root is high mucilage but you have to make sure it is deglycyrrhizinated if not it can cause many health problems. Mullein is high mucilage and helps with lung infections. Most edible plants in the daisy and sunflower family are high in mucilage. Wild Daisy helped me a lot. Pysillium seed husk are high in mucilage they are seeds from the plantain herb. Plantain herb itself is very high in mucilage. Wild violet is very high in mucilage. Chia seed is high in mucilage most seed is. Slippery Elm is high in mucilage but some claim it is high oxalate , I have never tried it. Most roots herbs are high in mucilage. Arrow root is very high in mucilage.

https://mavcure.com/mucilaginous-herbs/

https://www.invitehealth.com/article-demulcents-and-mucilages-true-healers.html

Probiotic Guide.

Do not get discouraged your gut can heal but it may take time.

https://www.prevention.com/health/a20469183/leaky-gut-syndrome/

If we do not correct it , it can lead to many health problems.

http://www.beyondmthfr.com/category/home-slider/

Leaky gut can lead to food allergies and chronic illness.

https://draxe.com/leaky-gut-test/

If you have been damaged by GMOs or antibiotics and have gut dysbiois and it feels like you have a brick in your gut after you eat, you may not be producing enough intrinsic factor which is needed in order for your body to absorb vitamin B12.  A deficiency in B12 causes many serious health problems. These are some things that may increase intrinsic factor.

http://www.sophiahi.com/how-to-increase-your-digestive-fire-by-jeannie-oliver-chc-cpt/

We need to avoid Omega 6 oils. Most of that comes from corn oil,soy bean oil, vegetable oil, and lard. Most of those are from GMOs also. They will cause inflammation in the body if we get too much.

Probiotics are one of the keys to healing the gut. They should be geared to what health issues we are dealing with.

http://www.myleakygutsyndrome.com/probiotics-for-leaky-gut-how-probiotics-can-heal-your-leaky-gut/

NSAIDs can damage the gut if taken for too long which can lead to many forms of chronic illness.

https://jeffreydachmd.com/2014/06/nsaids-small-bowel-leaky-gut/

Healing Leaky Gut

It is very important to

If you have Lyme there is very little knowledge in the medical community to assist with healing and fighting the disease it and other infections can raise zonulin levels causing leaky gut.. There are a few elite doctors who cared enough to do their own research. This is not medical advice. I am posting this to enable people to find the things they need to research to aid in their own healing. Always let your doctor know if you have any diet changes or you take any supplements. Always listen to your body, because it will tell you what is good for it and what is not. When you make any diet changes, whether it is supplements or food, only make one or two changes at a time so that if you have a reaction you will be able to identify what the cause of the problem is.

When you have leaky gut food particles can get into your blood stream which will raise your histamine levels. Signs of raised histamine levels are burning skin , headaches, confusion, fatigue, muscle spasms, blocked urinary track. The list goes on and on so it is very important to get the gut healed or you cannot fight infection or heal.

Healing the Gut

If you have any digestive problems you must take care of those first. Everything is tied to the digestive tract, even the brain. Problems with digestion can lead to a domino effect leading to trouble with hormones, bladder, liver the cardiovascular system, autoimmune system, and even mental health. If you do not get digestive problems taken care of you are fighting a losing battle whatever else you do.

Primary to getting the gut to heal is avoiding foods containing GMOs. They have been shown to damage the digestive system, among other issues.

If you are fighting an infection or dysbiosis the die off can cause bloating. I had to ease into things so I did not bloat too bad. Many probiotics can cause die off of pathogens and some of the bad gut bacteria which will also cause bloating.

Liquid Aloe Vera — this coats the stomach and helps it heal. It has also been shown to fight Candida and H-Pylori when they have switched from commensal to pathogenic forms. Has been shown to reduce oxalates.

Mucilage helps heal the gut. Some wild plants are high in mucilage like Wild Violets and Dandelion, the roots of Evening Primrose are high in mucilage. Plants in the mallow family are high in mucilage. Marshmallow root has many healing properties. The plants with the highest mucilage content are Spinach Vine, Irish Moss, Wild Yam, Fenugreek, Crushed Flax seed, Kelp, Marshmallow Root, Mullein, Okra, Psylium husk which is from the seeds of plantain herb, chia seeds and Broad Leaf Plantain herb. Some may have oxalates but we cannot avoid oxalates we need to address the issues causing high oxalates. Almost all foods have oxalates, cooking breaks down oxalates. But avoiding oxalates entirely will cause you more health problems then it would cure.

Mastic Gum — coats the stomach and has also been shown to fight many pathogens. This is

dried sap from the mastic tree and can be found in health food stores. Coating the stomachache is very important. I know mucilage can inhibit nutrient absorption but you cannot heal if you do not coat your stomach.

Biofilms

This is a list of things that break biofilms or aid the gut in healing. When the biofilms break up you will defecate mucous for about a month sometimes it will appear as if it is a piece of your intestine. I found that very scary and had to ask people who have went through it what it was. There is no information I could find to explain it. Breaking Biofilms is very important in healing our gut if our gut issues are from an infection..

Propolis — a resin produced by bees, so anyone with allergies to bees should not use this one. It has been shown to bust biofilms, kill many pathogens, and to promote gut healing.

Pepto-Bismol — I kept this on hand for when the aloe vera didn’t seem to help. You have to be careful you can herx from this because bismuth kills many pathogens. Bismuth has been shown to also break up biofilms.

phospholipids (good fats) – omega 3s are the best to use. Oils like grape seed oil, sesame seed oil , olive oil contain omaega 3s. Try avoiding Omega 6 it is needed by the body but if we get too much it can cause inflammation.

Garlic- garlic has many healing properties along with breaking up biofilms a killing pathogens. If you have high sulfite levels from having too many sulfur digesting bacteria this will make you ill because it is high sulfur and will raise your sulfite levels. I had this problem but one of the most potent chemicals in garlic is allicin and it does not cause issues with sulfites. I used it and it worked very well for me.

Stevia- it has to be Stevia extract because it needs the cofactors to work. Make sure you get organic because there is GMO Stevia. It also kills many pathogens including Lyme.

Xylitol-has very potent antibiotic properties. Many get cramps when they use it. I got cramps but I had an infected tooth and it worked very well for taking the infection out.

Cinnamon – breaks biofilms, high in mucilage coats the stomachache and helps with nausea. It has been shown to inhibit pain.

Cholesterol breaks biofilms is needed by almost all cells in the body. The brain and heart cannot function without it. Oxidative stress from leaky gut can cause high oxLDL. If you avoid cholesterol because of that you will be inhibiting your bodies ability to heal. When you reduce the source of the oxidative stress your oxLDL will return to normal. Cholesterol is an antioxidant and is used by the body to protect cells from pathogens. Cholesterol is needed to maintain the integrity of the digestive system and bladder.

Chlorophyll – fights Candida, helps remove toxins such as heavy metals from the body, and improves the health of our blood, as well as to protect the good bacteria. Sources of chlorophyll include green leafy vegetables and seaweed, but make sure the seaweed has come from a non-contaminated source. You can purchase liquid chlorophyll. I only used it for about a week and then I backed off to three times a week. There are many health benefits to liquid chlorophyll. It raises oxygen levels in the blood and restores the ph of our bladder and digestive system. It fights many pathogens. It feeds the good gut bacteria while reducing the bad. Those with SIBO will bloat when using this and herx from the die off of the sulfur digesting and methane producing bacteria. If you have SIBO and are going to use chlorophyll I would ease into using it. Liquid chlorophyll also raises oxygen levels in the body and helps restore the health of our blood cells.

Apple cider vinegar – helps fight Candida, breaks up biofilms and kills pain better then aspiron.

Mushrooms — bust biofilms, kill Candida, and fight many other diseases. Most mushrooms will do this. Mushrooms also contain glycoproteins which improve the bodies cell to cell communication so you can heal quicker. Glycoproteins also kill many pathogens so you could herx from them. Mushrooms also contain Beta Glucan which helps restore the good gut bacteria and fights pathogens.

Coconut oil — breaks biofilms and kills pathogens. It can even cross the blood brain barrier and improves brain health. The body converts coconut oil’s lauric acid to monolauren, which has been shown to fight many pathogens, reduce the number of Lyme spyrochetes in Lyme sufferers, and also crosses the blood brain barrier to contribute to improved brain health. Coconut oil contains many of the electrolytes needed by the body. When ill you need more electrolytes then usual.

Bromelain – breaks up biofilms helps fight pathogens , helps with digestion and reduces ammonia in the body.

Flax seed oil — breaks biofilms and fights pathogens. It has Omega-3 fatty acids which help protect the digestive system. Do not use too much flax seed and alternate the days you take it. Taking too much seems to cancel out its health benefits. Also has a canibinoid similar to thc so it reduces pain.

Inulin — promotes healthy bacteria in the digestive system, aiding in the break down and absorption of nutrients. Some sources of inulin are onions, garlic, bananas, dandelion root, chicory root, Jerusalem artichoke, asparagus, barley.

Oxalates.

Symptoms of high oxalates is joint pain, mental fog, anxiety , depression, kidney and liver pain, muscle fatigue, digestive pain, bladder pain, vulvodynia, indigestion when foods containing oxalates are consumed, and skin rashes. Many things can cause oxalates. Metabolic issues, leaky gut, high histamines, gut dysbiosis which cause there to be too many sulfur digesting and methane producing bacteria, which cause high sulfite level and high hydroxy radical levels which result in oxidative stress which also causes oxalates. Toxins such as glyphosate, glufosinate and many other farm chemicals. Also heavy metals, endotoxins, and alfoxins can cause oxalates to form. 

https://www.greatplainslaboratory.com/articles-1/2015/11/13/oxalates-control-is-a-major-new-factor-in-autism-therapy

http://www.lowoxalate.info/research.html

http://bioindividualnutrition.com/oxalates-their-influence-on-chronic-disease/

Oxalates break down when cooked so foods that are high in oxalates like spinach make sure you cook before eating. We cannot avoid oxalates they are in most food.

Oxalates prevent the body from healing and also hinder the gut from healing. That becomes a viscous cycle because when you have leaky gut you will develop high histamines and toxins can easily enter the blood stream, those also cause oxalates. Endotoxins and Afloxin can also cause oxalates. So it is very important to detox. Also metablolic issues and high sulfite levels can cause high oxalates so those should be addressed before detoxing. High sulfite levels can be caused from having too many sulfur digesting bacteria (gut dysbiosis). That in itself will cause many health issues like high ammonia levels. You can heal the gut with high oxalate levels but you must consume a lot of high mucilage foods to coat and protect the gut.

Here is a list of some things that reduce oxalates. I will post some links to some information also. 

https://chriskresser.com/how-to-prevent-kidney-stones-naturally/

http://www.beyondmthfr.com/oxalates-and-mthfr-understanding-the-gut-kidney-axis/

Oxalates cause inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807999/

We have gut bacteria that breaks down oxalates. If we are deficient in them it will raise our oxalate levels. They need the other friendly gut microbiome to establish. If we are lacking in the other gut bacteria they will not establish when we take them. They require an oligosaccharide to get established and remain in the gut. The also need sugar the type found in fruit , honey, or maple syrup will help them establish.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235702/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300851/

Oxalobacter Formingene

Bififobacterium Adolescentis

Bifidobacteriium Anamalis

Lactobacillus Acidophilus

Lactobacillus Gasseri

Lactobacillus Rhamnosus

Lactobacillus Planatarum

Enterococcus Faecalis reduces oxalates but consuming to much salt inhibits it’s ability to degrade oxalates.

Make sure you drink plenty of water. It needs to be free of chlorine or flouride because they cause oxalates and are very toxic to the body.

Avoid artificial sweeteners and processed sugar they can cause oxalates.

Sodium bicarbonate- be careful do not use more then a tablespoon in a glass of water it is a very strong base which means in high amounts it can cause burns. I only took it about 3 times a week.

Citric Acid which is not vitamin C helps reduce oxalates. Lemon juice is a good source of citric acid. It irritated my gut if I used it straight so I put it in my water with a little honey.

Do not take calcium get it from natural sources , calcium reduces oxalates but the calcium found in many supplements is the wrong type and can cause oxalates. Stinging nettles is one of the best sources of calcium. Most foods contain adequate amounts of calcium. If someone has bone loss it is usually from a magnesium or silica deficiency.

Excess salt causes oxalates. I use sea salt. Studies have found using sea salt cuts the craving for salt because of the trace minerals it contains.

Magnesium Citrate reduces oxalates. Also there are many metabolic pathways that need magnesium. When they do not have the nutrients they need oxalates can be produced.

Phytic acid found in grains can cause oxalates. We need phytic acid but should limit our intake of grains.

Foods that raise histamines like fermented foods, aged meats and some cheeses, also yogurt. High histamine levels can cause oxalates.

Vitamin B6 reduces oxalates, I had to use P5P because I wasn’t converting B6/

Vitamin E reduces oxalates. Most seeds contain vitamin E. If you eat flax seeds they have to be crushed or you will not digest them. Avocados are high in vitamin E. Also Olive oil is high in vitamin E. Mango and hazel nuts .

NAC N-Acetyl Cysteine reduces oxalates.

https://www.tandfonline.com/doi/abs/10.1080/10715762.2016.1221507?journalCode=ifra20

Aloe Vera has been shown to reduce oxalates.

Thiamine deficiency can cause high oxalates.

https://alobar.livejournal.com/2510679.html

Do not take more then 4000 IU of vitamin D it can cause oxaltes in very high doses.

https://www.ncbi.nlm.nih.gov/pubmed/8382134

Vitamin D in the correct amounts actually reduces oxalalates. There is a saying the poison is in the dose. I often find that to be true.

https://www.ncbi.nlm.nih.gov/pubmed/19734276

The flavonoids found in the white part of citrus fruits will reduce oxalates.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616898/

Eating too much meat can cause oxalates to form. mainly in those with metabolic issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1455427/

Spirulina reduces oxalates but some with high sulfite levels may have trouble with it. I can take it now but it did make me worse because it is high in sulfur.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972226/

http://redmountainclinic.com/the-down-side-to-high-oxalates-problems-with-sulfate-b6-gut-and-methylation/

We need vitamin C to heal. Ester-C has been shown to actually reduce oxalates and can usually be taken by those with interstitial cystitis.

If you have excess oxidative stress it can cause oxalates to form so it must be addressed.

Molybdenum helps reduce ammonia which can cause oxidative stress. Do not take too much it can be toxic if it get to high in our bodies. Many metabolic pathways need it but we do not want to overload on it.

Oxidative stress and oxalates.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788594/

Diet changes

https://www.rebootwithjoe.com/oxalates-kidney-stones-what-you-should-know/

Sulfation and oxalates.

http://www.beyondmthfr.com/side-high-oxalates-problems-sulfate-b6-gut-methylation/

Herbs for Healing

salsify, and burdock root. Some people are allergic to foods that contain inulin. Most foods that contain fiber that is hard to digest will help balance and protect the good gut bacteria. The allergic reaction is most likely a herx reaction and not an allergic reaction.

Acanthus Ilicifolius – increases production of osteoblast which are necessary for bone growth and health. Has been shown to help gastric ulcers heal. Has strong antibacterial and antifungal properties.

Embilia Ribes (False Black Pepper) — helps with flatulence, kills parasites, decreases homocysteine levels, and reduces symptoms of brain disorders. Lowering homocysteine levels would help with allergies and mast cell activation syndrome.

Pectin — breaks biofilms and lowers bad cholesterol. Pectin is a type of fiber. Food sources include apricots, peaches, apples, bananas, oranges, grapes, carrots, tomatoes and white potatoes.

Phospholipids — protect the digestive system, promote healing, and protect against cancer and infections. Some sources of phospholipids are butter, ghee, and mercury-free fish oil.

Butyric acid — protects our digestive system from infection, protects the body from cancer, aids in breaking food down into smaller particles that are easier for our bodies to absorb and make use of the nutrients. Butyric acid is produced when we consume hard to digest fiber, such as that in celery. It can also be found in ghee and butter.Also some of our microbiome produce this from fiber we consume.

Clove oil — has been shown to fight many pathogens and settles your stomach. This one really helped me because I was having trouble eating due to the nausea from my leaky gut.

Restoring Gut bacteria.

Probiotics — help restore the good bacteria to our digestive system, fight pathogens, and break down our foods. Choose a probiotic supplement with Bifidus and active Acidophilus cultures – the higher the number of cultures the better. The important gut bacteria to get is B Lactis , L Acidophilus, L Rhamnosus , L Salivarius, L Plantarum , B Animalis, B Longus, B Brevi, B Infantis.

Avoid things that contain Lactobaccilus Casei, L Lactis, L Reuteri, L Fermentum/Fermenti, L Paracaei, L Faecum , L Bulgaricus, Streptococcus Thermophilus.

If you start feeling bloated you may be getting to many good gut bacteria which can cause harm also. Get lots of prebiotics it feeds and protects the good gut bacteria and balances it out. Happy gut bacteria will help protect your immune system and help rebuild it.

Fireweed – Helps normalize gut flora, supports the good gut bacteria. Reduces inflammation and symptoms of irritable bowel syndrome. High in mucilage which heals the gut.

Bone broth — helps leaky gut and has the added benefit of containing many nutrients. If you have high sulfite levels or sufation issues you will need to address them before using this. It is high in glutamate and those issues can cause high glutamate levels which will cause very bad headaches and brain fog.

L-Glutamine — helps heal the soft tissue in the gut and is involved in many metabolic processes, fueling white blood cells and many other cells. Unfortunately, animal flesh is the best source of L-glutamine. I say unfortunately because if you have methylation problems digesting meat may be difficult for you. Whey protein and other dairy products are high in L-glutamine, as are eggs, nuts, seeds, lentils and other legumes, but all contain phenylalanine, which can also create problems if you are not methylating right.

I take betaine (trimethylglycine), derived from beets, to aid with the methylation. It has helped me I now rarely get ill when eating things that contain phenylalanine. Bromelain and papaya enzymes are also supposed to help with methylation. Cabbage is a good source of L-glutamine. If you have a blocked or upregualted CBS pathway , or an upregulated BH4 pathway and don’t address it this could make you ill. Most with those issues would benefit from taking P5P, selenium, and magnesium citrate. Also three times a week molybdenum and manganese.

If the pathways for using phenylalanine is blocked then foods high in phenylalanine will raise your ammonia levels and histamine levels which in turn can give you phenylaturia or homocysteinuria. Phenylaturia causes high ammonia levels which alkalize the digestive system and bladder making us prone to infection and dysbiosis. Protease enzymes may help with that. Meat is high in phenylalanine if you get ill after eating meat then you may have a problem.

If you eat foods that raise your glutathione levels like cruciferous vegetables then you may have a CBS pathway blocked which can make you feel ill. What helped me with that was P5P, Methylcolobamine and Molybdenum which I only take a few times a week.

— Avoid things high in tannic acid, such as coffee.

— Do not drink alcohol.

— Many things in processed foods can cause leaky gut, so try to eat foods made from whole, fresh ingredients.

Processed Sugar causes inflammation so try your best to avoid it in all its forms. Other sugars like those found in fruits, honey, organic black strap molasses have been found to fight pathogens and actually promote healing.

Lowering Histamine levels. Leaky gut causes high histamine levels which causes a loop that prevents us from healing because histamines cause inflammation.

Avoid foods high in histamines especially fermented foods, cheese and yogurt. Also avoid aged meats. Everyone is different, some can eat one high histamine food and not another and vice versa.

Things that help lower histamine levels. There are many protease enzyme that help with that I used Bromelain and Betaine along with serrapeptase because it helps dissolve scar tissue caused by chronic disease and also lowers histamine levels. Be careful even those protease enzymes are good for lowering histamine and homocysteine levels if taken to often it can lower your homocysteine levels too low.

Other protease enzyme that are supposed to work well like Papain and Nattokinase I have never tried them. Nattokinase is supposed to help with renal and lymph blockages. Nattokinase is supposed to help reduce carcinogenic estrogen levels.

American Skullcap Tea – not to be confused with chinese which has different health benefits. American Skullcap promotes relaxation, reduces seizures, inhibits food allergies. Has amazing healing abilities. I did experience problems with this at first because it improve the health of blood vessels and helps repair nerves. When I started to heal my nerves and muscles woke up and all heck broke loose. I had bad charlie horuses and burning in my nerves for three days but once my body got used to them working again it was like a big weight was lifted off and I could feel myself healing.

Wasabi – reduces risk of cancer and heart disease, has anti-inflammatory properties. Helps fight bacterial infections. It also reduces allergy symptoms and detoxes the body. Wasabi is packed full of nutrients.

Detoxing

Luffa Gourd – Strengthens the immune system, reduces fevers, detoxifies the body and aids the body with hydration. Has been shown to reduce heart palpitations and hair loss.

Oregano Oil – contains Carvacrol which protects the liver, has been shown to inhibit cancer growth. Works as a good nontoxic disinfectant. Has been shown to be as affective as chlorine. It kills Candida and helps protect the cardiovascular system from LDL and reduces inflammation.

Kills many pathogens.

Carnosine – detoxes the bodies cells of heavy metals has been shown to reduce some aging. Good sources are avocados, beans, bran, brewers yeast, brown rice, nuts, seeds, watercress, and spirulina.

L-ornithine and arginine is needed in the urea cycle to remove ammonia and other toxins from the body. Good sources of these are legumes,vegetables,nuts, seafood and seeds.

Indian Paintbrush (Castilleja) Only the flowers are eaten, the rest of the plant is too high in selenium. Has similar health benefits as garlic. It enhances the immune system. Helps the body to detox, the rest of the plant is too high in selenium to consume.

Garlic , Dandelion Tea, Red Rooibos Tea, Chlorophyll and Rattan tea are all good at detoxing the body. The protease enzymes also help with detoxing.

Lemmongrass – Lowers LDL, helps get toxins out of the body and lowers uric acid levels. Has been shown to be affective against cancer.

The essential oil has antimicrobial properties and has been shown to be affective against H-Pylori. Has also been shown to aid colitis. Calms muscles and nerves Helps relive pain including headaches. Has been shown to reduce the occurrence of convulsions and helps repair the immune system.!!Be careful some have had an allergic reaction to this.!!

White Peony Root – reduces diabetes induced oxidative stress. Decreases urinary albumin. Protects the liver from oxidative stress. RDA is 100 to 200 mg per kilogram of weight.

These are things that helped me heal.

Research them to see if they would help you.

Silymarin- milk thistle, heals cell damage helps repair methylation pathways. Helps repair nerve damage. I have heard complaints of this making people ill this is because certain liver disease can cause high iron levels and milk thistle is high in iron.

Kelp – has iodine which is needed by the body to keep the thyroids unblocked and to detox the body. Also has mucilage which helps heal the gut.

Aegle Marmelos – leaves are used. Inhibits lipid peroxidation, protects cells from damage, has antibacterial properties. Has been shown to fight cancer and is an adaptogen. Used to reduce chronic fatigue symptoms.

Vitamin D3 protects the cardiovascular system and nerves. Helps keep the immune system healthy. Us natural man made has been shown to have side effects. You should not take more then 4,000 IU, high doses can cause oxalates.

Ubuquinol- unoxidized form of CoQ10, use to provide the chromosomes with energy.

Quercetin- Helps heal leaky gut and nerve damage. The highest sources are elderberry juice, capers, Lovage, radish leaves, dill, Juniper berries, onions, red leaf lettuce, watercress and hawthorne leaves.

Honeysuckle- helps with cardiovascular issues and heals smooth muscle. Helps detox the body. Has mucilage which helps heal the gut.

Myricetin- helps reduce the symptoms of diabetes. Also shown to protect the nerves. Good sources are parsley, currants, yellow dock, cranberries, seeds, and blueberries. Has been shown to fight viral infections.

Kudzu- reduces histamines, and eases gastrointestinal problems. Lowers sugar levels. Helps fight cancer and is affective at aiding in suppressing alcohol cravings. Has been used to treat angina. Is an adaptogen so will help with adrenal fatigue.

Bacopa – heals brain and nerves, improves memory. Reduces ammonia levels in the body. Helps heal blood vessels throughout the body. Amazing herb.

Barberry – reduces swelling in spleen, antibacterial and anti-inflammatory. Has been shown affective against protozoa infections.

Tart Cherry capsules – helps fight heart disease , cancer, neuro-degenerative disease. Protects against muscle damage.

Maca Root helps replenish nutrients especially electrolytes. Is an adoptogen helps to balance the bodies hormones.

Ellagic Acid – inhibits binding of carcinogens to DNA. Reduces oxidative stress.

Sources are Black Berries, Cranberries, Raspberries, Strawberries, Walnuts, Grapes and Peaches. Must be coated to survive the stomache acid.

Tyrosine – if you are not methylating properly your body cannot produce it. It is used by your body to build neuro transmitters and various proteins.

Good sources are nuts, avocados, bananas, dairy products, beans and seeds.

Lotus Root – Improves digestion, reduces LDL, reduces stress hormones, strengthens the immune system and is loaded with many nutrients. Helps heal the gut.

Moringa Oleifera reduces oxidative stress and the illnesses cause by it. Helps heal leaky gut and reduce the risk of kidney stones. Also fights many infections.

Black Currant Seed Oil (Ribes Nigrum) Good source of Gamma-Linolenic Acid. Reduces arthritis symptoms, gastritis, stimulates production of anti-inflammatory hormones, helps suppress Postglandulin E2 boosting the immune system. Has been shown to be very affective at protecting the body from the flu.

Gotu Kola – has many minerals needed by the body. Has been used to treat syphilis, hepatitiis and other infections. Improves blood flow and reduces swelling in the legs.

Wild Bergamot (Monarda Didyma) – also known as horse mint. reduces fevers and nausea. Helps prevent cell damage. Has very strong antimicrobial properties. Has been shown to reduce gastric pain.

Biacalein (Thihydroxyflavone) – From the roots of Scutelleria Baicalense , Scutelleria Lateriflorg, and Oroxylum Indicum, also found in plantain herb and fleabane. Anti-inflammatory, helps heal smooth muscle also has antidepressant properties.

Glycoproteins – molecules that contain a sugar and a protein. They permit healthy cell to cell communication. They have been shown to fight bacteria, viruses, and cancer. They prevent carcinogens from attacking cells and making changes. They have been shown to strengthen the immune system.

Some have allergic reactions to them. I suspect it may be a herx reaction to a pathogen they may have that is dying off.

Foods high in Glycoproteins are mushrooms like the Reishi, Maitake, Cordyceps, Shitake and Oyster Mushrooms. Many dark colored fruits and vegetables contain them. Another source is whey protein. If you buy whey protein be careful if you have methylation problems because many companies add phenylalanine.

Choline – Needed to break down fats so our bodies can use them. Choline also helps with nerve repair. It also helps provide the body with more energy. Sources of Choline are eggs and milk products. The white parts of melons and the seeds of melons. If you get ill or indigestion when eating high choline foods it could indicate you are dealing with porphyria. I have posted on it.

Sulfur – has antimicrobial properties, has been shown to kill Candida. Sulfur is used in most processes in the body. Helps protect the lymphatic system and keep it healthy which important in the proper function of the immune system. If we do not get enough sulfur our Lymphatic System can become blocked.

Good sources of Sulfur are cruciferous vegetables, onions, garlic, kale, egg yolks from free range chickens. Cooking helps release sulfur from foods. Those with methylations issues and high sulfite levels need to address that before eating high sulfur foods.

Butchers Broom lowers ammonia levels, helps with hemorrhoids, reduces oxidative stress, has been shown to reduce the symptoms of POTS and Cardidtis. Has strong anti-inflammatory properties. Those with type 1 diabetes should not use this they could develop ketoacidosis.

Savory – has Oleanolic Acid and antioxidants. Aids in the repair of DNA. Is also an antispasmodic. Helps unblock Nrf2 pathway.

Mullein (verbascum thapsus) Has antibacterial and expectorant properties. Has also been shown to fight mycobacteria, Is a natural anti-inflamatory. Helps ease menstrual and stomach cramps. Helps normalize estrogen.

Zinc is necessary for the synthesis of proteins. Zinc is important for the proper function of the immune system, keeping eyes healthy, for healthy skin, protecting memory, repair and function of DNA and strengthening of bones.

Good sources of zinc are ginger root, fish, oats, whole wheat, !!Too much zinc inhibits the bodies ability to absorb copper!!

Chirata – reduces fever, fights things like malaria, Candida and parasites, also reduces nausea. Used in tincture form.

Cinnamon relieves gas, nausea, kills bacteria,H pylori, and Candida has been listed as a very affective pain killer.

Bee Pollen has many of the nutrients the body needs, it is a super food. High in protein.

Grape Seed Extract – thins the blood, reduces bradykinin which causes inflammation and damages nerves and smooth muscle. Also has many healing properties be careful it thins the blood. Helps with carditis. High in reveratrol.

Narigenin – found in grape fruit. Reduces histamines and inflammation. Has been shown to repair DNA. Reduces Hepatitis C. Has antidepressant affects. Cannot be taken with most medications. This inhibits cytochrome P450 enzymes needed to detox medication from the body. It should not be taken often but has been found to be very effective against gut dysbiosis. I only took it twice a week and it really reduced my bloating.

Fisetin- reduces inflammatory cytokines. Can up-regulate gluthione production. Good sources are most berries, fruits and vegetables. It also has nueroprotective properties.

Catuaba Bark – Opens blood vessels so blood can flow more easily, has anti-inflammatory properties, protects the skin from damage, has been shown to reduce symptoms of Parkinsons disease, has antidepressant affects, has been shown to be affective against HIV and other viruses.

Baai (Puerariathunergiana) – antiviral,antispasmotic, lowers blood pressure, shown to help with alcoholism. Scavenges free readicals and reduces alleric reactions. Makes HIV drugs more affective.

Caesalpinia Sappan – antibacterial, anti-inflammatory, reduces aging, protects liver and reduces acne. Helps prevent Peroxide formation, and lowers blood pressure.

Fulvic Acid – Helps the bodies cells to release heavy metals. Helps protect the brain from cognitive impairment. Promotes electro chemical balance throughout the body. Makes minerals more biochemically available. Has been shown to revitalize dying cells. !!Research has not been done on large dose intake of Fulvic Acid so do not overuse or take in large quantities.!!

Lower Cortisone

Lowering stress hormones can reduce histamines.

Eucommia Bark – encourages collagen development, lowers blood pressure. It does not lower blood pressure in those with low blood pressure. Strengthens the immune system and lowers stress hormones.

Purines and Pyrimidines – essential for building molecules that carry our genetic code and produce the proteins necessary for a healthy body.

Foods that support their production are foods high in glutamine, glycine and aspartate like greens , cabbage, oats, eggs, lentils, peanuts, almonds, legumes, all increases our production. !!If you have gout or inflammation high purine foods can make it worse, you may want to decrease your intake of animal flesh, asparagus, beans, legumes, mushrooms, scallops, sardines,coffee, tea and cocoa.

Lionsmane – high in protein, has neuro-protective properties. Lionsmane has been shown to improve memory and reduce plaque in the brain, it has also been shown to reduce depression.

Uridine – -Helps DNA repair. Foods that increase uridine are beer, wine, tomatoes, brewers yeast, broccoli, fish, nuts, molasses and Non GMO beets.

Suma Root – (Pfaffia Paniculata) an adaptogen, reduces fatigue, normalizes estrogen and testosterone. High in electrolytes and other nutrients.

Useful Info On Food And Herbs.

These are a list of things I have found in my research to try to heal from Lyme. This is not medical advice if you are not well see a doctor. If you take any supplements or herbs let your doctor know. Only take one new item at a time so if you have a reaction you will be able to figure out what caused the reaction. A good site for drug interactions is http://www.webmd.com .

Try your best to stay away from GMOs and vaccinations,processed foods with their saturated fats. By now you should know the harm they do to your body. I put this list together to give others an idea on some things they could research.

CoQ10 – Ubiquinol which is the unoxidized form of CoQ10 is the most bio-available form. It protects the mitochondria, cardiovascular system. It helps with the bodies energy production at the cellular level. It helps regulate blood sugar levels and improves the health of the immune system. It is fat soluble so must be taken with a healthy fat. Recommended Daily (RDA) allowance is 90 to 100 micrograms (mcg)

Lipoic Acid – First line of defence for disease. Regenerates antioxidants. Bio-active form is R-Alpha-Lipoic-Acid.

L-Carnitine – required to transport fatty acids to mitochondria, protects and heals nerves. Protects and heals nerves. Found in meat and milk products, also found in asparagus. Also helps remove toxic compounds generated in cells.

L-Glutamine – heals soft tissue.

Some sources are chicory root, Jerusalem artichoke, dandelion root, burdock, salsify, onions, and garlic.

Probiotic With Active Acidophilus and Bifidus – helps restore good gut bacteria. The good gut bacteria helps protect from cancer and infection, it also helps break our food down. Do not over do them or they will do the opposite.

Fermented Foods – Helps restore the bodies good bacteria, protects from infections and helps break our food down.They are high in histamines so if you are having high cytokine levels avoid fermented foods. Those with allergies or mast cell activation syndrome should avoid fermented foods.

Vitamin E (Tocopherols, Tocotrienols) With vitamin E always make sure it does not start with the letters DL, if it does then it is man made and our bodies does not use it very well.

Vitamin E Helps with energy production in the cells, protects the cardiovascular system, it is also and antioxidant. Sources of Vitamin E are nuts, seeds, greens, dark colored fruits and vegetables most organic cooking oils.

Vitamin C most bio-available form is Liposomal Vitamin C. The body needs Vitamin C to detox and repair the body. It has also been shown to fight many pathogens. Helps the body absorb Iron more readily. !! If you take too much Vitamin C you can flush important minerals from the body. It can also destroy red blood cells , also too much vitamin C can raise oxalate levels.!!

Virginia Pepperweed – contains isothioyanates which have antibacterial, antifungal, anticarcinogenic and anti-parasitic properties.

Allspice – anethetic, antioxidant, relaxant, stimulates blood circulation, stimulates cell growth and repair. !! In high doses causes many side affects. !!

Cat’s Claw – helps the body detox, also works as an adaptogen on the immune system.

Avena (Oat Straw) Helps balance our electrolytes. Has many nutrients needed for healing and proper functioning of the lymphatic system, helps improve cardiovascular health. Also has relaxant qualities and kills pain. Most say it doesn’t affect them but it knocks me out. Kills pain.

Boron helps remove toxins like chlorine.

Molybdenum – reduces oxidative stress, helps remove toxins produced by the body. It is needed to metabolize fats and carbohydrates. Also helps remove many other toxins from the body. Most do not need to supplement this. Good sources are greens, vegetables, seeds, melons, unfiltered water. Make sure you do not get too much. I sign of not having enough molybdenum is high ammonia levels.

Oleanolic Acid – Found in Olive Oil and Savory. It has been shown to unblock the Nrf2 pathways. If the Nrf2 pathways are blocked DNA and RNA cannot repair.

Vitamin D3 – helps regulate gene expressions, it also helps regulate epigenetic DNA methylation processes. Vitamin D3 has been shown to protect the cardiovascular system, it also aids in the absorption of calcium.

Zinc – Helps with DNA repair and synthesis of Protein. It is important for the proper function of the immune system. It helps keep the eyes, skin and memory healthy. It helps strengthen our bones. !! Too much Zinc can inhibit the bodies ability to absorb copper.!!

Good sources are shellfish, Oats, Whole Wheat, Ginger Root

Iodine – helps detox the body. It controls the function of the thyroid glands which affect metabolic processes in the whole body. It helps optimize the use of our bodies calories. The RDA is 75 to 150 mcg. Good sources of Iodine are seafood and seaweed. Unfortunately most sources of those are contaminated. Most table salt is enriched with iodine. Too much iodine can cause problems with the thyroids.

Magnesium – important in all the bodies functions, supports the immune system, prevents inflammation, reduces the risk of heart attacks.

Intake of Magnesium and Calcium should be balanced as closely as possible. The recommended RDA is 400 mg. Sources of Magnesium are leafy greens, bananas, most fruits and vegetables, oatmeal and chocolate. Most foods contain adequate amounts of calcium.

Calcium – Important for healthy bones and cardiovascular system. It is important for the regulation of the sodium pumps that control our muscles. Good sources of Calcium are found in greens, veggies, oranges and shellfish. Most foods contain adequate amounts of calcium and it is rare to need to supplement calcium. Most bone loss is from silica or magnesium deficiency.

Cholesterol – the body can produce Cholesterol. It is necessary for all body functions especially the brain. It helps the body break down and absorb fats. It is also important in the manufacture of hormones and balancing of the hormones. It is an antioxidant that protects our bodies from cancer. It is critical in the repair of damaged cells. A deficiency in Cholesterol can cause Leaky Gut Syndrome.

Sources of good Cholesterol are meat from grass fed animals, eggs, avocados, legumes and beans.

LDL is the oxidized form of Cholesterol which is bad for our bodies. It is found in grain feed meat, and processed foods.

Protease Ezymes – Supports good gut bacteria. Have been shown to aid with digesting cell walls of pathogens. Helps with methylation and lower homocystein levels which will lower ammonia levels. Some protease Enzymes are bromelain from pineapple, betaine from beets, and Papaya. Be careful of your source because there are GMO Papaya and Beets now. Nattokinase is a protease enzyme that has been shown to help with fatty liver disease. Serrapeptase reduces inflammation, reduces scar tissue in the body and improves blood flow.

Hops Tea inhibits cancer, known to remove many toxins from the body. Protects the renal system. Promotes proper functioning of the thyroid and has been shown to protect the cardiovascular system. Has been shown to fight many infections, even reduces aids symptoms. Has a cannabinoid that reduces pain. !! Overuse can cause seizures!!

Vitamin K2 – Prevents Osteoporosis, protects us from cardiovascular disease. Reduces cancer and Alzheimer conditions. It controls were calcium goes and does not go. Helps with the function of the muscles.

Good sources of Vitamin K2 are milk from grass fed cows for some reason grain fed cows do not produce very much K2 !! Do not confuse with K3 which is man made and toxic to the body.!!

Biotin – regulates gene expressions. Reduces CO2 levels in the body.

Some food sources are egg yolk, whole grains and cheese.

Lycopene – Helps protect the heart and reverse damage to the heart. Sources of Lycopene are cooked Tomatoes, grapefruit, pretty much all colored fruits and vegetables. Cooked tomatoes are the best source though.

Hyaluronic Acid – helps heal connective tissue throughout the body and skin.

Tumeric – contains Curcumin which has been shown to reduce MS sysmptoms and fight cancer. Has antimicrobial properties. It has also been shown to protect the renal system. Fresh ground pepper makes it more bio-available to the body. Should not be taken too often or for too long. Curcumin chelates iron so if taken for too long you can become anemic. It good for those suffering from iron overload.

Ginger – has many micronutrients and antioxidants. Has been shown to reduce inflammation. Improves blood flow. It improves the absorption of nutrients into the body. It stimulates the pancreas and is a natural pain killer. Has been shown to induce cell death in cancer cells. Promotes bone health and reduce menstrual cramps. Helps fight nausea and fight infections. Has been shown to heal the gut. I reacted to this the first few times I used it but after that I was fine.

Horsetail Herb – contains silica which the bones need for healing and to remain healthy, silicon is also needed by the body for detxoing. !!Some studies claim to much silica can cause kidney stones and others claim it does not. I would not over use. Do not take often, horsetail does contain a chemical that can be toxic if taken in excess!! Horsetail herb also has an alkaloid that can build up in the body so I would not use this often.

Panax Ginseng – Impedes cancer growth and promotes cancer cell destruction. Improves circulation which improves healing.

Rehman – helps with detoxing, has been shown to reduce fibromyalgia symptoms. Also helps regulate the immune system. !! Can cause bloating!!

Honeysuckle – many antioxidants, has been shown to kill bacterial infections. Heals smooth muscle and cardiovascular system. This one helped with my myocarditis.

Policasamol – prevents blood clots helps regulate blood pressure, also balances cholesterol. It is extracted from sugar cane. It reduces inflammation.

Butchers Broom – Has been shown to reverse osteoporosis. Lowers ammonia levels in the body.

Evening Primrose (Oenothera Biennis) Has Gamma Linolenic Acid (GLA) which has been shown to heal many areas of the body even smooth muscle. Very good for skin health.

Citruline – helps remove ammonia from the liver. Helps strengthen the immune system. Also helps to maintain nitrogen balance in the body. Studies have shown it reduces atherosclerosis. Helps reduce fatigue and increase energy in the body.

Sources of Citruline are melons, sguash, legumes, and protein rich foods.

Clary Sage – benefits eyes, nervous system, also aids in digestion. Helps regulate blood pressure and normalize it. Has antispasmodic properties.

Eupatorium Perfoliatum – also known as Boneset and Feverwort. It has been shown to be affective against the common cold and the flu. Aslo affective at treating cytokine dysregulation. Has been shown to be very affective against the plasmodian parasite.

White Peony Root – reduces diabetes induced oxidative stress. Decreases urinary albumin. Protects the liver from oxidative stress. RDA is 100 to 200 mg per kilogram of weight.

Bupleurum – promotes new vein growth and strengthens capillaries. !!Stimulates the immune system and causes flatulence!!

Coltsfoot – anti-inflamatory and eases coughs.

Fireweed – Helps normalize gut flora, supports the good gut bacteria. Reduces inflammation and symptoms of irritable bowel syndrome.

Silver Weed (Potentilla Anserina) The leaves have antiviral properties, and contains more flavonoids then green tea. Has been shown to be hepatoprotective.

Manganese – Necessary for proper brain function and pituitary function. Manganese is also necessary for healthy bones and works as a coenzyme to assist in metabolic activity.

Good sources of manganese are berries, pineapple, garlic, greens, Non GMO beets, fruits, vegetables, molasses, and coconuts.

L-Dopa (Levodopa) The body uses it to make Dopamine. Our bodies will produce it but many who are ill do not produce enough.

Good sources of L-Dopa are Fava Beans, Mucuna Pruriens, and Broad Beans. Those who are G6PD deficient should not eat Fava Beans.

Good carbohydrates – Good carbohydrates stabilize things throughout our bodies. Good sources are sweet potatoes, oats, brown rice, legumes, beans, quinoa, fruits and vegetables.

Jaiogulan – (Gynostemma pentaphyllum) Helps the body achieve homeostasis by lowering oxidative stress. Has many of the same phytochemicals as gensing. Reduces oxidative stress and inflammation.

Uridine – -Helps DNA repair. Foods that increase uridine are beer, wine, tomatoes, brewers yeast, broccoli, fish, nuts, molasses and Non GMO beets. I would not supplement , high levels of uridine can stimulate cancer growth. That being said uridine stimulates growth of brain and nerve cells. It reduces pain and inflammation. It increases cognitive abilities. It works best if consumed with fish oil.

Wasabi – reduces risk of cancer and heart disease, has anti-inflammatory properties. Helps fight bacterial infections. It also reduces allergy symptoms and detoxes the body. Wasabi is packed full of nutrients.

Oregano Oil – contains Carvacrol which protects the liver, has been shown to inhibit cancer growth. Works as a good nontoxic disinfectant. Has been shown to be as affective as chlorine. It kills Candida and helps protect the cardiovascular system from LDL and reduces inflammation.

Lionsmane – high in protein, has neuro-protective properties. Lionsmane has been shown to improve memory and reduce plaque in the brain, it has also been shown to reduce depression.

Luffa Gourd – Strengthens the immune system, reduces fevers, detoxifies the body and aids the body with hydration. Has been shown to reduce heart palpitations and hair loss.

Nobiletin – prevents metabolic syndrome. Protects from obesity, prevents artheriosclerosis. This is extracted from the peels of citrus fruits. Stimulates cellular macrophagy. Should not be used more then a couple times a week.

Fulvic Acid – Helps the bodies cells to release heavy metals. Helps protect the brain from cognitive imparement. Promotes electro chemical balance throughout the body. Makes minerals more biochemically available. Has been shown to revitalize dying cells. !!Research has not been done on large dose intake of Fulvic Acid so do not overuse or take in large quantities.!!

Aerva Lanata – has diuretic, anti-inflammatory, antispasmodic, antiparasitic, antimicrobial, hepa-protective and anti-asthmotic properties.

Agrimony – reduces inflammation, improves digestion, improves bladder control, detoxes the body and improves hair and nail health.!!Taking too much can cause constipation!!

Cissus Quadrangularis – reduces inflammation, improves bone health, improves respiratory health, eases pain and stimulates the production of osteoblast which are needed for bone growth and healing.

Camu Camu – high in vitaminb C, helps block build up of plaque in the brain, reduces symptoms of depression, improves muscle tone.

Black Radish – used to treat nutritional deficiencies. Helps remove toxins from the blood. Has antimicrobial and antibacterial properties.

Eucommia Bark – encourages collagen development, lowers blood pressure. It does not lower blood pressure in those with low blood pressure. Strengthens the immune system and lowers stress hormones.

Moringa Oleifera – has antibacterial properties. Has been shown to stabilize blood pressure. Helps reverse some liver damage. Contains Quercetin. The seeds have been shown to improve asthma symptoms. Also reduces histamine levels.

Graviola (Annona Muricata) – soursop has been shown to kill cancer cells, suppresses the herpes simplex virus. Has been shown to reduce swelling and pain. !!Taking to long or too much can damage nerves. !!

Celery Seed Extract – reduces risk of stroke. Improves blood flow and has been shown to protect the brain. Also lowers histamines and inflammation. Has been shown to help heal leaky gut.

Periwinkle – helps bleeding gums, reduces Alzheimer symptoms, reduces headaches and vertigo.

Black Currant Seed Oil (Ribes Nigrum) Good source of Gamma-Linolenic Acid. Reduces arthritis symptoms, gastritis, stimulates production of anti-inflammatory hormones, helps suppress Postglandulin E2 boosting the immune system. Has been shown to be very affective at protecting the body from the flu.

Olive Leaf Extract – has antibacterial , and anti-inflammatory properties. Lowers blood pressure and LDL levels. Olive Leaf Extract has been shown to protect the cardiovascular system. It is a broad spectrum antiviral and antimicrobial agent. !!Be careful it can drop your blood sugar levels.!!

Aegle Marmelos – leaves are used. Inhibits lipid peroxidation, protects cells from damage, has antibacterial properties. Has been shown to fight cancer and is an adaptogen. Used to reduce chronic fatigue symptoms.

Hydrangea Macophylla Root – helps with autoimmune disorders while allowing the immune system to function normally.

Bethroot (Trillium Erectum) Stimulates menstration, is an expectorant, can stimulate labor during pregnancy.

Acanthus Ilicifolius – increases production of osteoblast which are necessary for bone growth and health. Has been shown to help gastric ulcers heal. Has strong antibacterial and antifungal properties.

Boabab – high in vitamin C, much more then oranges. Has very good hepaprotective properties. Loaded with minerals. Can be purchased as a powder.

Bakula (Mimusops Elengi) diuretic, gastroprotective, antibacterial, antifungal, anticancinogenic, scavenges free radicals, has been shown to hinder HIV.

Cynanchum Stauntonii – improves endothelial function, inhibits the formation of atherosclerosis.

Ajuga Decumbens improves liver and kidney function, helps correct hypoglycemia.

Caesalpinia Sappan – antibacterial, anti-inflammatory, reduces aging, protects liver and reduces acne. Helps prevent Peroxide formation, and lowers blood pressure.

Sea Bean (Salicornia) – High in protein,calcium and iodine. Has many micronutrients.

Bitter Ash (Picrasma Excelsa) Reduces colitis symptoms, and has antiviral and antibacterial properties.

Cancer Bush (Sutherlandia Frutescens) Fights cancer has been shown to reduce HIV symptoms.

Maytemus Heterophylla – has antibacterial and antimicrobial properties. Reduces inflammation.

Baai (Puerariathunergiana) – antiviral,antispasmotic, lowers blood pressure, shown to help with alcoholism. Scavenges free radicals and reduces allergic reactions. Makes HIV drugs more affective.

Catuaba Bark – Opens blood vessels so blood can flow more easily, has anti-inflammatory properties, protects the skin from damage, has been shown to reduce symptoms of Parkinsons disease, has antidepressant affects, has been shown to be affective against HIV and other viruses.

Spatholobus Suberectus – strong antiviral, improves the health of blood, reduces arthritis symptoms, anti-inflammatory, affective against cancer, thins blood and has sedative affects.

Quaking Aspen (Populus Tremuliodes) High in salicylates which is converted to aspirin in the body. Reduces pain, fever, inflammation, thins blood, detoxes the body and has antibacterial properties.

Club Moss, Devils Claw (Lycopodium Clavatum) anti-inflammatory improves memory.

Bee Pollen – High in protein, contains almost all nutrients required by humans. There is a substance in be pollen that inhibits the development of bacteria. It strengthens our blood. Normalizes cholesterol and has been shown to help fight cancer.

Geranium Pelargonium – this is the only Geranium species that can be consumed. It is an adaptogen, reduces stress hormones, reduces pain and inflammation, reduces headaches, helps the body to detox by stimulating the kidneys. Has antifungal and antibacterial properties. Has been affective at reducing cold and flu symptoms.

Wild Bergamot, Horse Mint ( Monarda Didyma) Settle stomach, reduces fevers, helps prevents cell damage, helps with urinary tract infections.

Indian Paintbrush (Castilleja) Only the flowers are eaten, the rest of the plant is too high in selenium. Has similar health benefits as garlic. It enhances the immune system. Helps the body to detox, the rest of the plant is too high in selenium to consume.

Apple Leaf helps heal the gut.

https://link.springer.com/article/10.1007%2Fs13765-015-0021-2

Lemon Verbana (Glycyrrhiza Glabra) reduces muscle damage, improves joint mobility and reduces joint pain. Improves the health of the immune system.

Red Rooibos Tea (Aspalathus Lenearis) Has antiviral, anti-inflammatory,antimutagenic qualities. Scavenges free radicals. It is a relaxant with many minerals needed for bone health. Protect the cardiovascular and pulmonary system. Helps with colic in babies. Also helps detox the body and is very good for fighting lung infections.

Star Grass (Hyposis Hemerocallidea) Has antibacterial and anti-inflammatory properties. Has been shown to be affective against breast cancer. Has been shown affective against HIV.

Lithospermum Erthrohizon – inhibits HIV virus, prevents ovalation in women with no side affects. Also hinders hardening of the arteries.

Sweetflag (Acorus Calamus) reduce epilepsy symptoms. Kills Candida and fungal infections. Hinders inflammatory cytokines. Has been shown to be affective against cancer.

Bixa Orellena (Annatto) – Used to treat gonorrhea and many other bacterial infections. Helps prevent DNA damage. Reduces oxidative stress and protects the renal system.

Bearberry (Uva Ursi) helps with urinary tract infections. I have seen websites saying it can damage the liver but when I looked at toxicity studies it showed it to be safe. It reduces oxidative stress and kills infections in the renal system.

Pau D Areo Tea (Tabebuia Allanedae) – Fights cancer, kills bacterial infections, and is affective at killing parasites. !! Do not concentrate it contains Quinone which can damage the liver in high doses.

Use no more then two 8 ounce cups a day.!!

Mustard – anti-inflammatory. Has been shown to help with chest congestion. Very high in antioxidants and lowers LDL.

Sage reduces muscular pain, improves memory and reduces oxidative stress.

Sarsparilla (Smilax) Has been used to treat gonorrhea, leprosy, bacterial and viral infections. Has anti-inflammatory affects. Has been shown to limit the amount of toxins that can enter the blood stream. It protects the renal system and reduces oxidative stress.

Vitex (Chasteberry) Supports the endocrine system. Works as and adaptogen for women.

Thyme (Thymus Vulgaris) Shown to increase white blood cell production. Has a relaxing affect on the muscles. Has been shown to reduce oral infections. Has many minerals like copper, iron, and manganese. It boost the feeling of well being. !! If taken in large doses has many side affects!! Also will work as an insect repellent.

Andrographis – fights many pathogens. It has many antimicrobial properties. Boost the bodies immune system. Can prevent and dissolve blood clots. Relaxes smooth muscle which lowers blood pressure.

!!Has many side affects!!

Galangal Root (Alpinia Officicaram) Relieves nausea, has antifungal and anti tumor properties.

Golden Rod (Solidago) a diuretic, has been shown to fight bacterial and urinary tract infections. Eases muscle spasms and reduces high blood pressure. Helps with reducing ammonia and other toxins in the body.

Juniper Berries – has been shown to inhibit bacteria growth. !!Long term use can cause liver damage!!

Schisandra – has antioxidants and anti-inflammatory properties. It is also an adaptogen. It has been shown to reduce stress hormones and improve concentration. Has been used to treat hepatitus. !!only use a few berries at a time and not for extended periods of time.!!

Tribulus Extract (Puncture Vine) Boost endurance and helps increase muscle mass. Similar chemically to anabolic steriods. Boost testosterone production. Strengthens the immune system. Reduces oxalates in the body.

Mullein (Verbascum Thapsus) has antibacterial and expectorant properties. Has also been shown to fight mycobacteria. Is a natural anti-inflammatory. Helps ease menstrual and stomach cramps.

Siberian Ginseng – each type of ginseng has it’s own properties. You must research which ones are best for you. Siberian Ginseng is an adaptogen. It has been shown to lower stress hormones. Studies suggest that it may strengthen the immune system. It has been shown to reduce the number of outbreaks of herpes. It has also been shown to improve mental health. !!Do not give to a child, if you have high blood pressure do not take.!!

Ladies Thumb (Polygonum Persicarla) Has antiherpetic properties. High in saponins which aren’t toxic but if consumed in high quantitites they can inhibit nutrient absorption.

Smartweed (Polygonum Pennsylvnicum) Has the same properties as Ladies Thumb, looks similar also.

Myricetin is a heliacase inhibitor. Helps fight viral infections. Also has anti-inflammatory properties. Has many antioxidants. Most dark colored produce contains Myricetin.

Croton Lechleri the sap is latex and is used as a liquid bandage. It has been shown to heal gastric ulcers.

Borage – Contains choline which is needed for methylation. Shown to reduce stress hormones. Do not use in hight doses or it will do the opposite. It contains an alkaloid that can damage the liver and kidneys if it builds up in the body.

Noni Extract has antioxidants and immune boosting properties. Helps lower blood sugar and is high in pottassium.

Hovenia Dulcis – protects the renal system, reduces oxidative stress. Helps to protect the brain. RDA 1400 to 2500 mg.

Polygala Tenifolia – reduces stress hormones improves memory.

Bacopa – heals brain and nerves, improves memory.

Bromelain extracted from pineapple. Reduces pain and inflammation. Has anti parasitic and antimicrobial properties. Kills Candida. Promotes muscle and connective tissue repair.

Aloe Vera contains Latex which helps heal leaky gut. Has been shown to kill Candida and help regulate the immune system. I get the liquid capsules, I do not like the textures of the juice. The dried capsules didn’t seem to work. Has been shown to reduce histamine levels.

Chamomile – reduce muscle spasms, reduces pain and menstrual cramps. Also reduces histamines.

Wild Daisies -related to Chamomille does the same things only taste better.

– reduce muscle spasms, reduces pain and menstrual cramps. Also reduces histamines. Also reduces pain and has mild sedative effects.

Tongkat (Eurycoma Longifiolia) enhances bodies adaptive response to exercise, also increases testosterone levels.

Muira Puma – aprodisiac in men and women. Helps the body produce healing hormones.

Maca Root gives the body energy. High in minerals and vitamins. Stimulates and nourishes the hypothalamus and pituitary glands which control all other glands. Helps the body achieve homeostasis.

Dandelion – high in vitamin K, has been shown to protect the renal system and to aid in the removal of toxins from the body. Has many antioxidants and micronutrients that help fight cancer. Reduces histamines.

Ellagic Acid – inhibits binding of carcinogens to DNA. Reduces oxidative stress.

Sources are Black Berries, Cranberries, Raspberries, Strawberries, Walnuts, Grapes and Peaches.

Potassium -helps keep the heart healthy, aids in blood flow, helps keep muscles healthy, helps protect nerves also helps the liver filter blood. Helps balance our water levels. !! Too much can cause major heart issues.!!

Sources are Tomatoes, Avocados, Bananas, Oranges, Strawberries, Grapes, Prunes, Beans and Legumes.

Astralagus – protects the chromosomes from degredation. Boost immune system and reduces oxidative stress.

Hawthorne – Improves circulation protects blood vessels. Helps with osteoporosis. Reduces oxidative stress.

Vitamin A -allows for proper gene activation within the lymph glands which helps the body develop proper immunity.

Sources are orange colored fruits and vegetables, Kale and fish.

Red Clover Tea – improves bone health, increases estrogen production.

American Skullcap Tea – not to be confused with chinese which has different health benefits. American Skullcap promotes relaxation, reduces seizures, inhibits food allergies.

Prickley Lettuce – contains opiad like Lacturearium, but is not addictive.

Vitex also know as Chasteberry. Supports the endocrine system. Aslo works as an adaptogen for women.

Tribulais Extract (puncture vine) Boost endurance and helps increase muscle mass. Similar chemically to anabolic steroids. Boost testosterone production and strengthens the immune system.

Mullein (verbascum thapsus) Has antibacterial and expectorant properties. Has also been shown to fight mycobacteria, Is a natural anti-inflamatory. Helps ease menstrual and stomach cramps.

Chinese Knotweed (Fo-Ti) Strengthens bone and prevents hair loss. Supports healthy adrenal function.High in oxalates should not be taken if you are not sulfating right or have issues with vitamin C should not take this.

Zinc is necessary for the synthesis of proteins. Zinc is important for the proper function of the immune system, keeping eyes healthy, for healthy skin, protecting memory, reapair and function of DNA and strengthening of bones.

Good sources of zinc are ginger root, fish, oats, whole wheat, !!Too much zinc inhibits the bodies ability to absorb copper!!

Ginger Root improves blood flow, reduces nausea, improves absorption of nutrients into the body, ginger root also stimulates the pancreas, and is a natural pain killer. Ginger Root has been shown to induce cell death in cancer cells. Ginger Root promotes bone health, has been shown to fight infections and reduce menstrual cramps. Reduces histamines.

Horse Gram (Dilichos Biflorus) Help dissolve kidney stones, also kills many pathogens. The seeds are used to make tincture.

Cambogia (Cortexmoutan Radycus) Helps asthma. shown to upregulate Il-4. Cambogia also thins the blood.

Figwort – Good for the lymph glands and improves blood circulation improves the function of the cardiovascular system.!!Do not use if you are a diabetic.

Coptis (Berberine) The root is used. Coptis aids digestion and the pancreas, kills many pathogens and parasites. Usually comes in tincture or powder form.

Vervian – antispasmotic, helps recover nerve function. Relieves menstrual symptoms. Used in tincture or tea form.

Phellodendrum Amurense – Alleviates arthritis pain, improves bone health, helps preserve nerve function, increases glutathione levels, is also antimicrobial.

Woad – (Isatis Tinctoria) Antibacterial, antiviral and has been shown to inhibit cancer. Root used to make tincture. !!Do not use if you are allergic to aspirin.

Chirata – reduces fever, fights things like malaria, Candida and parasites, also reduces nausea. Used in tincture form.

Forsynthia Suspensa – fights lung infections, tonsillitis, and gonorrhea. Forsynthia also thins the blood.

Verbena – antispasmodic and and reduces fever. Flowers used for tea.

Yarrow (Achillea Millefolium) Has antimicrobial properties, lowers blood pressures. Has been used to clot blood in wounds. The essential oil kills mosquitoes.

Eclipta (Eclipta Prostracta) Reduces oxidative stress, protects the liver, has been shown to reduce pain better then aspirin and stimulates hair growth.

Yellow Dock also known as Curly Dock. Has laxative properties, high in iron, also has antibacterial properties. Has Glycosides that aid with detoxing and mineral absorbtion. !! The leaves are High in oxalates which can cause gout and kidney stones do not eat the leaves without cooking.!!

Red Clover – flowers are used to make tea. Has estrogen like affects. Helps with symptoms of menopause. Can reduce estrogen levels if they are high. Works as an expectorant and antispasmodic.

Varuma – Bark, root and leaves are used. Good at breaking up kidney stones, also hinders their formation. Has anti-inflammatory affects. The root is a laxative. Varuma also helps with flatulence and gas pains. !!May cause blistering if used on the skin!!

Tansy (Tanacetum Vulgare) – Leaves and flowers are used. Gets rid of parasites. Also a good insect repellent.

Passion Flower – Aids with opiate withdrawal, has sedative affects. Has been used to treat ADHD. Has been shown to ease symptoms of drug withdrawal. !!Do not drive or operate machinery when using.!! Long term use can damage the liver.

Bitter Mellon also know as Bitter Gourd – Has many vitamins and minerals. Helps with diabetes. Has antiviral and antibacterial properties. !!Overuse can cause digestive problems and headaches.!!

Nutmeg – Strong antibacterial properties. Has been shown to reduce the occurrence of seizures. Good for diarrhea. !!Over use of this can do the opposite, it can cause seizures and could even cause death.!!

Serrapeptase -derived from a type of silk worm bacteria.It aids the moth in digesting the cocoon so it can exit the cocoon. Serrapeptase has been shown to remove scar tissue from fibrosis, break up blood clots, reduce scar tissue in the lungs, break up cyst and even plaque in the blood vessels. It is PH sensitive so it must be coated. Do not take high doses, it can negative impact the body in high doses.

Papain – aids digestion of proteins. Has been own to reduce symptoms of many herpes viruses !!Do not take if you are allergice to papaya, also be careful I think there is GMO Papaya.!!

Spirulina Provides protein, many vitamins and is a good source of chlorophyll. Very high in Gamma-Linolenic Acid. Has the same minerals as milk. Improves blood vessel elasticity, which improves neuro-protective affects. !!Make sure the source is from uncontaminated waters.!!

Opium Lettuce helps with spastic colon.

http://europepmc.org/articles/PMC3638630

Those who have issues with their digestion that causes the food to sit and ferment instead of digesting properly my not want to use apple cider vinegar. It delays digestion even more.

https://www.ncbi.nlm.nih.gov/pubmed/18093343

Yarrow helps heal the gut.

https://www.sciencedirect.com/science/article/pii/S0378874106001565?via%3Dihub

Also read my post on Beta Glucan because it helps heal the gut.