Written by Lee Stevenson sorry I am a lousy editor.
This is not medical advice and should not be taken as such. I am writing this for educational purposes if you are ill find a reputable naturopath who is knowledgeable and has a good reputation I do not recommend anyone treating themselves.
This is going to discuss how cells in our bodies respond to excess uric acid. Many do not see how serious the damage to the body uric acid does. It can lead to life threatening health issues. Gout is the least of the worries when it comes to uric acid.
When cells come in contact with uric acid they leak serotonin , ATP, ADP and there is a loss of lactic acid dehdrogenase, or beta-glucuronidase. When this occurs excess cellular lysis occurs. IgG is also released and immune complexes to be released. Now we will discuss what the consequences of each of these things occurring is.
The loss of cellular ATP and ADP will cause the body to have to switch to another source of energy. It is a very inefficient way for the body to produce energy so a person will experience fatigue and most likely experience weight gain. Those who are more chronic may experience sever weight loss. This also shuts down the citric acid cycle. Oxidative phosphorylation needed for many mitochondrial process gets shut down. This reduces the ability for the body to heal. This will also effect many hormones in the body and a person most likely will develop high estrogen levels. They may show symptoms of high estrogen but estrogen levels may be normal but progesterone levels will be reduce causing the same symptoms as estrogen dominance.
There is a loss of lactate dehydrogenase or beta-glucuronidase caused by the release of aggregated IgG or immune complexes. The loss of lactate dehydrogenase cause a loss of the ability to convert lactic acid to pyruvate resulting in acidosis. The body can no longer convert NAD to NADH and back. Lactate dehydrogenase is released during cellular injury, it prevents muscle failure and fatigue. It helps maintain proper ATP levels. Which farther adds to the fatigue a person will experience. Vitamin C taken in excess can also cause a loss of lactate dehydrogenase. Beta-glucuronidase is needed for the break down of complex carbohydrates for energy. Beta-glucuronidase converts bilirubin to unconjugated so it can be reabsorbed from the intestines so this can result in liver and kidney damage. There is a loss of glycosaminglycans (GAG) which is needed to maintain the health of the bladder, gut, membrane, blood brain barrier, cartilage, joint, bones, eyes and soft tissue in the joints. Loss of beta-glucuronidase causes the blood brain barrier to leak leading to brain inflammation and possible damage, interstitial cystitis, arthritis, connective tissue loss, damage to tendons and joints. It can also lead to leaky gut or gut inflammation.
Excess IgG in the blood stream causes the bodies immune system to turn on the body. This results in autoimmunity. This can lead to hepatitis, cirrhosis of the liver, connective tissue destruction, joint damage, systemic inflammation.
The excess serotonin in the blood stream causes irritability, agitation, restlessness, and anxiety. This can also cause muscle tremors, muscle rigidity, and muscle spasms, rapid heart beat, high blood pressure, excess sweating. A person may experience confusion, dizziness, or become disoriented.
This can be complicated even farther if someone take nicotinamide for the fatigue because it increases serotonin in the body.
The increased lysis caused by the uric acid causes the intracellular contents to leak into the blood stream, these are potassium, phosphate, and nucleic acids to leak into the blood stream. This results in hypercalcemia, hyperphosphatemia, hyperuricemia because this also increases uric acid levels, and acut kidney injury. Uric acid crystals and calcium phosphate crystals occur which are damaging to the body especially the renal system. This can lead to vaginosis and vulvadynia and cause interstitial cystitis.
Hypercalcemia (excess calcium in the blood) blocks sodium channels and inhibits depolarization, this can cause slower reflexes and muscle weakness, cardiac arythmias, fatigue, nausea, vomiting, kidney impairment, increased urination especially at night and increased thirst.
Hyperphosphatemia (excess phosphorous in the blood) can cause calcium depositsin the soft tissue, brain, lungs, eyes, arteries, muscles, and organs. This can result in organ failure. When it occurs in the muscles they become tender and lose flexibility. This can also result in damage to the heart valves.
Hyperuricemia can be caused by infection, gut inflammation , high glyphosate levels, eating processed foods which cause systemic inflammation, eating to many foods high in biogenic amines, issues in removing uric acid from the body, leaky gut which most do not realize they have. This can also result from gut dysbiosis especially if a person has to many microbes involved in protein proteolysis. Because the damage uric acid causes to the cells also increases uric acid levels it is a very difficult positive feedback loop to break. Uric acid is excreted in both the urine and intestinal tract. If we have inflammation in the gut or leaky gut the body cannot reduce the uric acid quickly enough. Insulin overload, iron toxicity can also increase uric acid levels. This is why it is very important to do our best to get uric acid levels down because things can rapidly decline and the higher levels get the harder the cycle is to break. Lithium helps break down the uric acid. Alkalizing the urine also helps to reduce uric acid levels. If there is an infection it must be addressed. There are many metabolic issues that can also cause high uric acid levels.