Things that may help with lysosomal storage disease.

 

Written by Lee Stevenson. Sorry I am a lousy editor.

This is not medical advice. I am posting this for educational and information purposes.

Those who have lysosomals storage issues I noticed also have gut issues.  This is a post on things that may help those with the most difficult gut issues and may help those with lysosomal storage issues. It takes time to heal and lots of research and patients. You have to develop your own protocol there is no one size fits all. As you heal you have to adjust your protocol.

Humanin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800795/

Autophagy and immune system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766433/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036178/

https://www.sciencedirect.com/science/article/pii/S0022283618305308?via%3Dihub

Lithium helps with lysomoal protein degreadation by stimulating autophagy.

https://www.hindawi.com/journals/ijcb/2014/135908/

Inhibiting mTOR helps with lysosomal storage disease, by stimulating autophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437338/

https://www.jci.org/articles/view/94130

Autophagy helps correct Lysosomal Storage issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869865/

L-leucine and SPNS1 helps with LSD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698481/

SPNS1 is required for activation of mTOR to induce autophagy.

http://www.pnas.org/content/108/19/7826

https://academic.oup.com/toxsci/article/153/1/198/2223974

https://www.tandfonline.com/doi/full/10.1080/15548627.2016.1256934

Autophagy also corrects issues involved with fatty acid abosorptions.

https://www.ncbi.nlm.nih.gov/pubmed/28697336

Autophagy corrects lipid metablolism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930069/

Hypoxia increases V-ATPase. V-ATPase is needed for stomach acid production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543021/

Many with Lysosomal Storage issues have IBS, this is information on enzymes that may help.

https://www.dietvsdisease.org/digestive-enzyme-supplements/

https://www.sciencedirect.com/science/article/pii/S1590865818302093

Endothelium and LSD.

https://watermark.silverchair.com/cvq386.pdf?

http://journals.sagepub.com/doi/pdf/10.1177/1076029613489595

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579558/

Green Tea may help with LSD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452227/

Nobiletin may help with LSD by inducing autophagy. Autophagy helps clean out the cells.

https://www.sciencedirect.com/science/article/pii/S1388198118300350?via%3Dihub

https://www.ncbi.nlm.nih.gov/pubmed/28116779

https://www.annualreviews.org/doi/abs/10.1146/annurev-nutr-071715-050718?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=nutr

A list of nutrients that my restore autophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135626/

Spermidine found in wheat germ, mangos and mushrooms restore macrophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044119/

Exercise induces autophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463459/

Beta glucan may help with LSD.

https://academic.oup.com/femspd/article/35/1/67/529284

https://www.researchgate.net/publication/259474009_Oat_beta-glucan_ameliorates_insulin_resistance_in_mice_fed_on_high-fat_and_high-fructose_diet

Whey protein may help.

https://www.researchgate.net/publication/8112776/download

Increasing TEFB expression may help with LSD.

https://www.ncbi.nlm.nih.gov/pubmed/27556060

Akt inhibition increases TEFB.

https://www.nature.com/articles/ncomms14338

Curcumin activates TEFB.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968239/

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006177

Autophagy corrects lipid metablolism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930069/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247383/

Sidt2 deficiency can inhibit autophagy.

https://www.ncbi.nlm.nih.gov/pubmed/29363559

Autophagy corrects lipid metablolism which is needed to produce bile and digestive enzymes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930069/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247383/

Hydrogen peroxide is needed for lipogenesis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369955/

https://www.sciencedirect.com/science/article/pii/S0014579300021979

SOD increases H2O2. The only bioavialable source in food is the chaga mushroom.

https://jonbarron.org/herbal-library/nutraceuticals/superoxide-dismutase

http://www.worthington-biochem.com/sodbe/default.html

Curcumin increase SOD but should not be taken too long it chelates iron and can cause anemia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705117/

http://www.raysahelian.com/superoxidedismutase.html

I found this study interesting ghrelin effects glycogen storage.

https://www.rug.nl/research/portal/files/14503024/06_c6.pdf