This is not medical advice I am posting this for educational and informational purposes. Naturopathic doctors usually already have this type of knowledge and it would be a good idea to seek one if you are ill.
Vitmain D Receptor.
Homeostasis should always be the goal. If you over do things you can cause just as many health problems as you are trying to address. If we have an inhibited VDR receptor we will develop gut dysbiosis. It is important in maintaining balance of our gut microbiome. Inhibited VDR also causes intestinal inflammation. A person can become deficient in iron and their GABA levels may become low. I have posted in other blog post how to increase GABA. Lactoferrin and Knotgrass help restore iron homeostasis. Knotgrass should not be mistaken for Knotweed they are very different plants.
If the vitamin D receptor becomes inhibited we will develop digestive problems , inhibited bile and malabsorption. We will also develop lipid dysfunction. We can also develop autoimmunity and will be more prone to herpes type virus infections along with tuberculosis. Toxins and infection inhibit the vitamin D receptor especially mercury and glyphosate. I have posted on detoxing. When proper function of VDR is inhibited a person may appear to be deficient in vitamin D.
In some with inhibited VDR taking vitamin D can make them worse they need to address the cause not the symptom. This is usually caused by infection which can inhibit cyp24A1 enzyme.
How to increase Cyp24A1 enzyme activity. Do not over do it because it can cause deficiencies in certain types of vitamin D from causing their depletion. Homeostasis should always be the goal. Decreasing inflammation should also be a priority because inflammation inhibits cyp24A1. Curcumin and resveratrol found in grape seed extract stimulate Cyp24A1. Curcumin chelates iron and should not be used for too long because if used for too long it can cause anemia. Forskolin increases cyp24A1 activity. High FGF-23 levels will inhibit VDR.
Reducing phosphate and adrenal hormones helps reduce FGF-23. Reducing inflammation also decreases FGF-23. They often time recommend ferric citrate to lower potassium which lowers FGF-23 but this can lead to iron toxicity so if used it should be done in moderation. Calcium carbonate and calcium acetate help reduce phosphate levels. Chocolate, soda pop, bottled beverages and beer should be avoided they are high in phosphate. Milk products, beef liver and fish eggs are also high in phosphate. Phosphate binders should be taken with meals.
Loss of VDR receptor can cause hair to become brittle and you may start losing your hair, you can develop osteoporosis, your insulin level may become high while your blood glucose levels will become low. You may develop joint pain and swelling and fibromyalgia like symptoms. You will develop severe bone pain.
Excess vitamin D will cause excess thirst, high oxalate levels, loss of appetite, abdominal pain, muscle fatigue, confusion and weakness.
Zinc, Vitamin K2, Vitamin A, Vitamin E are needed and sulfate which is found in water from volcanic sources. Those who are not sulfating right or have high levels of sulfide in their bodies need sulfate because they will not be able to convert food sources of sulfur and it will make them sicker. Brown seaweed and cod liver oil has many of the nutrients needed by the vitamin D receptor. Sardines and eggs are good sources of vitamin D.
Halogen light, sunlight or far infrared will help detox hormones from the body.
High adrenalin levels can also inhibit the VDR. Adaptogens may help to reduce adrenal hormones. Maca root and suma root helped me. Ashwanga is a very potent adaptogen but be careful because as I stated it is potent. Rhodiola and Eluethero have been shown to be very effective and safe adaptogens.
Excess estrogen can interfere with proper VDR function. Low dose boron can help detox excess estrogen. Soaking in epsom salt and then getting sunlight, far infrared or halogen light will also help detox carcinogenic estrogen. High estrogen levels causes high T4 thyroid hormone levels and low T3 hormone levels.
Calcium D Glucarate inhibits B-Glucuronidase which increase glucuronosyltransferase activity which helps remove glucuronide groups from the body. Many toxins are glucuronidated including carcinogenic hormones. This helps remove estrogen from the body. It also reduces DHEA and steroid hormones. I would not use this daily but I would pulse it. This has been shown to help with interstitial cystitis.
High dose vitamin D can inhibit the VDR receptor but low dose can stimulate it.
If the vitamin D receptor is inhibited Thymosin B4 will be inhibited. Thymosine B4 is needed for tissue regeneration and also needed for the body endogenous steroids to reduce inflammation. If deficient Thymosin B4 a person will develop dry eyes. Thymosin B4 is used to cure dry eyes.
If the vitamin D receptor is inhibited the absorption of iron, zinc, magnesium and calcium will be inhibited. Also vitamin D inhibits inflammation and the release of histamines.
Increasing Sirt1 can stimulate the vitamin D receptor. It is also known as the longevity gene. Fasting activates Sirt1. Resveratrol activates Sirt1. It is found in high levels in red wine and skins of grapes. It is also found in high levels in grape seed extract. When Sirt catalyzes a reaction NAD+ is required. Curcumin increases Sirt activity but should be used in moderation because it chelates iron from the body and can eventually lead to anemia if used for too long. Querciten increases Sirt activity. Berberine dramatically increases Sirt1 activity. Ferulic Acid found in wheat germ, white navy beans and angelica increase Sirt activity. There are many things that can increase Sirt.
Now the down side to Sirt1 and why homeostasis should always be the goal and we must be careful not to over do things. Over activation of Sirt can cause excess oxidative stress which can lead to damage in the body.
High adrenal hormones, high T4 level, high phosphatonin levels and high prolactin levels can inhibit the VDR receptor. Autophagy reduces all of those. Things that stimulate autophagy are fasting, fulvic acid, nobiline, resveratrol. High phosphatonin is a sign of leaky gut or other digestive issues. It is caused by high Fibroblast Growth Factor 23 which increases when we have digestive issues. Causes of high prolactin can be a dopamine deficiency, or issues metabolizing dopamine, or hormone imbalances. High FGF-23 inhibits the VDR.
High TGF-B levels can inhibit VDR. High TGF-B is and indication of T-cell or B-cell imbalance. I have posted on increasing T regulatory cell which help balance the immune system. High TGF-B can be caused by mold toxins. Symptoms of high TGF-B levels are low acetylcholine levels, muscle loss, bone loss, frequent infections, increased serotonin levels, decreased immune response but increased inflammation.
High Phosphatonins can be a sign of low klotho levels. High phosphatonins can indicate severe kidney disease, high cellular damage, high vitamin D levels or ketoacidosis. Symptoms of high phosphatonin levels are muscle cramps or spasms, bone and joint pain, bone loss, rashes or itchy skin. A diet low in phosphate will help reduce symptoms until the problem is corrected.
Vitamin A and K2 are needed for the vitamin D receptor to function properly.
Increasing klotho will decrease phosphatoin levels. To increase klotho decrease toxins in the body. Exercise can increase klotho. Carbohydrates increase insulin which increases klotho. Probiotics acidophilus, and Lactobacillus Lactis increases Klotho. There are natural ACE inhibitors which increases klotho. Some natural ACE inhibitors are whole cooked rice, peas, sea food, chitin , brown and red algae, Pleurotus cornucopiae mushroom, matsutake mushroom, walnuts, pomegranate, Onopordon acanthium also known as cotton thistle, banana, bitter melon, Lactobacillus Plantarum , Lactobacillus Casei, bacillus subtilis, termina chebula, cooked tomato skin, rice bran, and hemp seed. Our commensal E Coli produce ACE inhibitors.
If prolactin levels are high a person will lose their sex drive, experience hypothyroidism, and mental distress. In women it can disrupt the menstrual cycle, and they can have seepage from the breast, vaginal dryness and painful sex. High prolactin levels can cause headaches and blurred vision. A person may experience hot flashes.
Ashwagandha decreases prolactin and increases testosterone. Vitamin E reduces prolactin, cod liver oil is a good source of vitamin E. Vitamin B6 reduces prolactin levels. Maca Root reduces prolactin levels. Sleep and zinc help reduce prolactin levels. Chasteberry, ginger, clove and cayenne pepper lowers prolactin levels. Also avoid foods contaminated with endocrine dysruptors especially GMO which are high in glyphosate. Increasing dopamine decreases prolactin. Avoid foods in containers that have BPA in them. Do not use plastics for food that contains BPA.
Sirt1 increases VDR activity. I have posted on stimulating Sirt. Fasting, querciten , grapes seed extract and many other things can stimulate Sirt1.
Omega 3s found in fish oil, coconut oil and olive oil can activate the VDR receptor. Some who have pyrrole issues they may have to use medium chain fatty acids instead. Medium chain fatty acids can be readily used by the body without having to be converted. Some sources of MCFA are coconut oil, unpasteurized raw animal milk(goat milk contains some of the highest levels), palm kernel oil, Durio graveolens which is in the durian family but is red and does not smell like dead animal like the others. Macadamia nut and pumpkins seeds are also high in MCFA. Butyric acid found in Ghee and butter and produced by some of our gut bacteria provides MCFA. Cocoa butter made from cocoa beans is high in stearic acid. Nuts are high in MCFA. You may also see them referred to as medium chain triglycerides, MCTs.
For those who are not sensitive to methyl donors SAMe can restore VDR function but I would not take it excessively or for too long.
Here is a link with good information on the vitamin D receptor.
I covered vitamin D more in depth by this post.