Things that may help those who have the more difficult digestive problems.

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This is not medical advice I am posting this for informational and educational purposes.

If you truly want to heal it takes time and persistence. You have to develop your own protocol there is no one size fits all your protocol must be unique to you and your health problems. There is no magic bullet, pharmaceuticals treat the symptoms not the cause. So you may feel better but will slowly get worse until you will start needing other medications to hide the new symptoms that arise from the declining health which pharmaceuticals contribute to.

It takes a lot of research and patients. Take notes of what works and what does not and keep readjusting your protocol. As you heal your protocols will need to change.  Homeostasis is the goal once you start feeling better try cutting supplements out. If it goes well then take a maintenance dose of the supplement once in a while.

Mucilage every few hours helps a lot with leaky gut. When you have leaky gut it causes high oxalate levels. This causes a cycle that is hard to break because oxalates prevent the gut from healing. Mucilage can help heal the gut breaking the cycle. Mucilage helped me the most with healing my gut.

Things that are high in mucilage are Okra, organic Oatmeal, Aloe Vera I found the liquid gel worked the best dried aloe vera seemed ineffective. Besella Alba known as Malabar Spinach, Irish moss but you have to watch consuming it, it has a cannabinoid that reduces pain but has side effects if you consume too much. Most plants in the mallow family are very high in mucilage and have very good healing properties. Most plants in the dioscera family are high in mucilage especially the chinese wild yam. Fenugreek is high in mucilage. Flax seeds are high mucilage but if you have leaky gut they should be ground up to prevent other heath issues. Most seaweeds are high in mucilage. Licorice root is high mucilage but you have to make sure it is deglycyrrhizinated if not it can cause many health problems. Mullein is high mucilage and helps with lung infections. Most edible plants in the daisy and sunflower family are high in mucilage. Wild Daisy helped me a lot. Pysillium seed husk are high in mucilage they are seeds from the plantain herb. Plantain herb itself is very high in mucilage. Wild violet is very high in mucilage. Chia seed is high in mucilage most seed is. Slippery Elm is high in mucilage but some claim it is high oxalate , I have never tried it. Most roots herbs are high in mucilage. Arrow root is very high in mucilage.

https://mavcure.com/mucilaginous-herbs/

https://www.invitehealth.com/article-demulcents-and-mucilages-true-healers.html

Various gut microbiome and what they do.

https://www.vitamodularis.org/articles/how_to_interpret_your_microbiome_data.shtml

https://biofoundations.org/increasing-and-maintaining-akkermansia-muciniphila-for-a-healthy-gut-microbiome/

Oregano oil kills just about all pathongens in the gut.

https://www.bmj.com/content/352/bmj.i939/rr-1

Sage also is effective against bad gut bacteria.

http://www.scielo.br/scielo.php?pid=S0034-89102004000200025&script=sci_arttext&tlng=en

Verbana fights Citrobacter. I don’t know much about it but it has sedative effects and helps with seizures.

https://www.cogentoa.com/article/10.1080/23312009.2017.1363342.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5174135/

Beta Glucuronidase is low it can effect hormones. If it is high it can cause toxins reabsorption.

https://biofoundations.org/maintaining-a-proper-balance-of-beta-glucuronidase-for-disease-and-cancer-prevention/

High beta glucuronidase causes high estrogen.

https://www.planetnaturopath.com/hormones/high-beta-glucuronidase-and-how-it-affects-estrogen-and-detoxification/

Herbs that strengthen the immune system.

http://www.chiro.org/nutrition/FULL/Bacteria_That_Strengthen.shtml

We also need to reduce oxidative stress and nitrositive stress.

https://iamajuicer.wordpress.com/2018/08/02/oxidative-stress-the-antioxidant-systems-and-how-they-effect-our-health/

https://iamajuicer.wordpress.com/2018/07/11/nitrosative-stress/

Streptoccocus bacteria produce an exotoxins streptolysin and NAG -glycohydrolase which help it evade the immune system.

Inhibiting NLRP3 helps resolve the issues Streptolysin causes. It uses a tactic similar to Lyme disease it stimulates inflammation to evade the immune system.

https://www.frontiersin.org/articles/10.3389/fcimb.2018.00211/full

Rabdosia contains oridonin which inhibits NLRP3.

https://www.nature.com/articles/s41467-018-04947-6

There are a number of ways being used to inhibit NLRP3 inflammasome.

https://www.frontiersin.org/articles/10.3389/fphar.2015.00262/full

Resveratrol, quercetin and curcumin are NLRP3 inhibitors.

https://www.hindawi.com/journals/mi/2016/5460302/

Paeonia is a CBR2 activator which inhibits NLRP3.

https://www.ncbi.nlm.nih.gov/pubmed/25854559

CB2R receptor activation protects and heals the nerves.

https://www.nature.com/articles/cddis2014364

Hypoxia reduces NLRP3 and induces autophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524634/

https://www.tandfonline.com/doi/full/10.4161/auto.22783

bacillus subtillus kills most bad gut bacteria.

https://aac.asm.org/content/59/11/6844.full

https://www.tandfonline.com/doi/full/10.4161/viru.29514

https://www.sciencedirect.com/science/article/pii/S0168160511007136?via%3Dihub

We need butyrate producing bacteria to protect from inflammation. Also it protect the brain.

https://gut.bmj.com/content/63/8/1275.long

Fodmap diet helps with IBS.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555627/

Increasing Treg through FOXP3 cells helps.

https://www.hindawi.com/journals/jdr/2013/621693/

https://www.ndcn.ox.ac.uk/publications/692350

Our gut bacteria regualate T Reg cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276397/

https://ctajournal.biomedcentral.com/articles/10.1186/s13601-016-0108-9

Mycobacteria can inhibit NOD2 which can cause gut issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316803/

Infection can lead to NOD2 deficiency this causes a reduction in V-ATPase which is needed to produce stomach acid.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316803/

https://www.ncbi.nlm.nih.gov/pubmed/25335775

https://www.frontiersin.org/articles/10.3389/fimmu.2016.00367/full

Over stimulation of NOD2 can also make us prone to infections and chronic illness. Homeostasis should be the goal.

https://www.nature.com/articles/srep08383

https://www.spandidos-publications.com/10.3892/etm.2017.4288

https://www.kidney-international.org/article/S0085-2538(15)55943-7/pdf

HSP70 Restores NOD2 function. I have posted on HSP70

https://pubs.acs.org/doi/abs/10.1021/acs.biochem.7b00470?src=recsys&journalCode=bichaw

http://www.jbc.org/content/289/27/18987.long

Our diet and many probiotic strains can induce HSP70 which will restore NOD2 function which would restore dendric cell funtion.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892289/

Trypterygium Wilfordii may help restore NOD2 function though this is a single case report.

https://journals.lww.com/md-journal/fulltext/2017/11270/Case_report___remarkable_remission_of_SAPHO.114.aspx

Our diet and our gut interactions.

https://www.frontiersin.org/articles/10.3389/fimmu.2016.00290/full

Sulfation is involved in hormone production and use. Gut dysbiosis, glyphosate, mercury and other toxins can inhibit sulfation. This can result in hormone dysregulations. This can also result in high DHEA levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016456/

https://www.ncbi.nlm.nih.gov/pubmed/28153960

https://www.ncbi.nlm.nih.gov/pubmed/30087535

To much hydrogen sulfide producing bacteria lead to chronic illness.

https://www.physiology.org/doi/pdf/10.1152/physrev.00017.2011

https://pdfs.semanticscholar.org/1fda/f6c18c0b184ae8e41c8a777b2979bedd2494.pdf

Too many methane producing bacteria can lead to constipation there are some probiotics that will help with that.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609747/

http://www.talkingaboutthescience.com/studies/Donohue-Sulfoxidation.pdf

The craziest part of all of this is I seen supposed pathogens that could correct many of these issues but did not include them in this but they turn certain genes of which could restore the function of non-functioning genes.

Diets effect on gut bacteria.

https://www.aivpa.it/files/upload/rivista_articolo/00152_microbioma-dieta-disturbi-gastroenterici-e-disbiosi.pdf

https://watermark.silverchair.com/fux022.pdf?

http://www.drwallyschmitt.com/Newsletters/issue-43-molybdenum/

http://www.drmyhill.co.uk/wiki/Fermentation_in_the_gut_and_CFS

Tributyrin found in butter helps with dysbiosis

https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.994.9

https://biofoundations.org/multiple-health-benefits-tributyrin-triglyceride-form-butyrate/

Sulfur regulation in the body is very improtant.

https://www.mthfrsupport.com.au/wp-content/uploads/2017/04/PPT-CBS-Pathway-Final-full-page-slides.pdf

Dysbiosis often leads to impaired renal function.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431124/

Those who have gut issues will be deficient in short chain fatty acids and they are very important in maintaining our health.

https://biofoundations.org/multiple-health-benefits-tributyrin-triglyceride-form-butyrate/

Many will have high oxalate levels which are produced endogenously. I have posted on oxalates. This can prevent the gut from healing.

https://mthfrsupport.com/2018/03/understanding-sulfation-and-oxalate/

http://www.lowoxalate.info/research.html

https://people.csail.mit.edu/seneff/DC2016/CynthiaSmith_DC2016.pptx

Autophagy corrects lipid metablolism which is needed to produce bile and digestive enzymes. Bile homeostasis is very important for the health of the whole body.

http://jem.rupress.org/content/early/2018/01/12/jem.20171965.long

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930069/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247383/

Hydrogen peroxide is needed for lipogenesis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369955/

https://www.sciencedirect.com/science/article/pii/S0014579300021979

SOD increases H2O2. The only bioavialable source in food is the chaga mushroom.

https://jonbarron.org/herbal-library/nutraceuticals/superoxide-dismutase

http://www.worthington-biochem.com/sodbe/default.html

Curcumin increase SOD but should not be taken too long it chelates iron and can cause anemia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705117/

http://www.raysahelian.com/superoxidedismutase.html

http://www.foodtrients.com/inside/sod-do-you-know-about-this-powerful-antioxidant/

Sidt2 deficiency can inhibit autophagy. Unfortunately I have not research this Gene much.

https://www.ncbi.nlm.nih.gov/pubmed/29363559

Though I do not believe in taking enzymes the body can produce if all else fails what else are we to do. Often times taking enzymes the body can produce can disable the bodies ability to produce them.

https://empoweredsustenance.com/fat-malabsorption/

Increasing brush oder enzymes helps with malabsorption.

https://www.ncbi.nlm.nih.gov/pubmed/11346204

You must heal the endothelium to correct malabsorption. Saccharomeyces Boulardii is needed for that. This also improve lipid abosorption.

https://www.ncbi.nlm.nih.gov/pubmed/29762474

https://metabolichealing.com/villous-atrophy-leaky-gut-intestinal-dysbiosis/

Dietary nucleotide supplementation helps heal the digestive tract.

https://www.sciencedaily.com/releases/2014/04/140416143313.htm

https://www.selfhacked.com/blog/dietary-nucleotides-health-benefits-of-nucleotides/

https://www.researchgate.net/publication/275771517_Nucleotides_supplementation_improves_various_function_of_the_body

https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1440-1754.2002.00056.x

Mucins and tight junctions regulate what passes in and out of the intestines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548832/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095905/

High zonulin levels causes the gut to become more permeable.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458511/

High zonulin levels has been linked to many diseases.

https://www.mygenefood.com/zonulin-leaky-gut/

https://www.jillcarnahan.com/2013/07/14/zonulin-leaky-gut/

Probiotics to reduce zonulin.

https://www.realnatural.org/probiotics-help-reduce-intestinal-permeability-also-called-leaky-gut-syndrome/

colostrum reduces zonulin.

https://www.researchgate.net/publication/316676047_Oral_Supplementation_with_Bovine_Colostrum_Decreases_Intestinal_Permeability_and_Stool_Concentrations_of_Zonulin_in_Athletes

https://www.naturalnewsblogs.com/healing-leaky-gut/

Brush border enzymes are needed to break down and absorb food.

http://www.vivo.colostate.edu/hbooks/pathphys/digestion/smallgut/bbenzymes.html

https://www.core3training.com/can-improve-gut-overall-health/

Black Seed Oil improves carbohydrate digestion.

https://www.ncbi.nlm.nih.gov/pubmed/28959553

Thyme improves brush border enzymes.

https://www.ncbi.nlm.nih.gov/pubmed/29223554

How bile is secreted.

https://www.ncbi.nlm.nih.gov/pubmed/29262229

http://www.sophiahi.com/how-to-increase-your-digestive-fire-by-jeannie-oliver-chc-cpt/

Foods that contain natural digestive enzymes.

https://www.healthline.com/nutrition/natural-digestive-enzymes#section2

They mention Kiwi in this one. It is high oxalate so would not be good for someone who has leaky gut.

https://starmystuff.com/top-7-foods-contain-natural-digestive-enzymes

 

I am sorry these are things I forgot to post with this post. It is concerning restoring the ability to produce short chain fatty acids.

Diasccharidase in involved in our digestion and absorption of carbohydrates and sugars. If we are not producing enough then our food will sit and ferment in our upper intestine possibly feeling like a brick is sitting in our stomaches. This will cause excess gas and can lead to the production of hydroxl sulfide which inhibits sulfation and can cause issues with the CBS and BH4 pathways. This can lead to high ammonia levels, proteinuria, phenyketonuria and even porphria. Infection can cause this, an imbalance in our gut bacteria brought on by farm chemicals especially glyphosate, antibiotics, and even chemicals found in processed food. If you have diarrhea and you are not absorbing then you may be producing too much disaccaride which is an indication of high insulin levels. High oxalates will prevent the gut from healing. I have posted on oxalates and the gut. If we produce too much diasaccaride then we will experience similar symptoms only instead of being constipated we would have diarrhea.

https://drhoustonanderson.com/disaccharidase-deficiency-causes-and-treatment/

Vinegar seemed to help me but this studies shows it actually reduces Disaccharidase. Not sure what to think about this one.

https://academic.oup.com/jn/article/130/3/507/4686196

We know those with IBD usually have high insulin levels showing they have lost their sensitivity to insulin. This leads to high leptin levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159716/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959465/

I know those with IBD connot do some of these things. You have to learn to figure out what in the information that is out there you can apply and what you cannot.

https://www.healthline.com/nutrition/improve-insulin-sensitivity#section8

Though being insulin resistant is usually found in obesity it is common in many inflammatory bowel disorders.

Increasing insulin sensitivity will help with leptin levels.

https://www.marksdailyapple.com/25-ways-to-improve-your-insulin-sensitivity/

https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/

Increased insulin levels inhibits disaccharidase levels.

https://www.ncbi.nlm.nih.gov/pubmed/21946084

Decreased insulin levels increases disaccharide levels.

http://www2.ufpel.edu.br/biotecnologia/gbiotec/site/content/paginadoprofessor/uploadsprofessor/8aff603648377229ebdb3b655ecdf854.pdf

Now if you look at MAPK it is involved in IBD. So now we can see the connections. We need to increase insulin sensitivity . I read many research articles and decreasing insulin levels seem to make IBD worse but improving insulin sensitivity improved IBD. Inhibiting TNF-a improves insulin sensitivity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792822/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859792/

There are naturals that inhibit TNF-a but nothing that inhibits it directly. Also inhibiting it for too long makes us more prone to infection.

https://www.researchgate.net/profile/Solomon_Habtemariam/publication/12454244_Natural_Inhibitors_of_Tumour_Necrosis_Factor-a_Production_Secretion_and_Function/links/09e4150bb180eefd74000000/Natural-Inhibitors-of-Tumour-Necrosis-Factor-a-Production-Secretion-and-Function.pdf?origin=publication_detail

Resvertrol inhibits TNF-a it is found in grape seed extract.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091406

Reducing insulin levels reduces P38 MAPK which reduces symptoms of IBD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218950/

Those who have IBD have been found to be deficient in bacteria in the up digestive track especially Oscillospira and Akkermansia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573342/

https://helda.helsinki.fi/bitstream/handle/10138/236401/Akkermansia_muciniphila.pdf?sequence=1

Lactobacillus Fermentan increases Akkermansia.

https://www.ncbi.nlm.nih.gov/pubmed/28935567

Host microbe prebiotic and fiber interactions. Interesting lets you know how each type of saccharide effects the gut bacteria.

https://www.tandfonline.com/doi/full/10.1080/19490976.2017.1290756?src=recsys

Studies confuse me, some says stay away from carbohydrates will others show that those carbs increase the very bacteria those who have IBD are deficient in.

https://academic.oup.com/jcem/article/101/1/233/2806797

Beta Glucan found in Oats and mushrooms increases Oscillospira.

https://www.frontiersin.org/articles/10.3389/fmicb.2017.00966/full

Meditarrian diet can increase Oscillospira.

https://www.ncbi.nlm.nih.gov/pubmed/26505825

L-arginine has been found in many studies to help normalize the gut bacteria even in chickens.

https://www.ncbi.nlm.nih.gov/pubmed/28901890

Nanosilver can kill specific gut bacteria depending on the size and shape. In theory this could be used to reduce specific gut bacteria that may be too numerous.

https://www.researchgate.net/publication/241100111_Comparison_of_the_anti-bacterial_activity_on_the_nanosilver_shapes_Nanoparticles_nanorods_and_nanoplates

The shape of the silver determines which bacteria it is effective against.

https://www.ncbi.nlm.nih.gov/pubmed/28588204

Glutamine reduces Oscillospira which would be detrimental to IBS.

https://cfsremission.com/2017/10/15/decreasing-oscillospira-genus/

Black Raspberries increase Oscillospira.

https://www.ncbi.nlm.nih.gov/pubmed/29502392

Most with IBD are difficient in Oscillopira. This is found in the upper digestive tract. I believe it is the cause of the low disaccharidase production but I cannot find studies to prove it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437018/

A deficiency in Oscillopira causes food allergies.

Food additives have a negative impact on the gut.

https://www.ncbi.nlm.nih.gov/pubmed/29914144

This is a good list of bacteria and what they do. Bifidobacteria Bifidum and Breve increase short chain fatty acid production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964481/

Our gut bacteria regulate cell that produce antibiotics.

https://www.frontiersin.org/articles/10.3389/fmicb.2018.00736/full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801817/

More on Oscillopora.

https://www.datapunk.net/substrata/display.pl?119852+S

Bile acid also increases Oscillopora.

https://onlinelibrary.wiley.com/doi/abs/10.1111/1758-2229.12319

https://drjockers.com/25-ways-improve-gallbladder-health/

Gut homeostasis is controlled by the endocannbinoid system. Those with inflammatory bowel issues have been found to have low endocannbinoids. This raises diaglycerols which can prevent the proper production of digestive enzymes leading to the inability to digest and absorb saccharides and produce short chain fatty acids (carbohydrates and sugar). This is caused by the upregulation of the protein kinase pathway.

https://www.ncbi.nlm.nih.gov/pubmed/22917662

Black pepper increases endocannbinoids which would help with IBD.

https://www.ncbi.nlm.nih.gov/pubmed/24412246

HSP70 is a transport for anamide and other endocannabinoids. I have posted on HSP70.

FAAH inibitors increase endocannabinoids.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882713/

Biochanin A found in read clover, the red covering on peanuts, and in chick peas is an FAAH inhibitor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931556/

Here is information on other cannabinoids and their effects on the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429335/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538700/

Kaempferol found in pine tree bark extract and magnolia is an FAAH inhibitor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538700/

Bilirubin is inhibited with IBD and other inflammatory bile diseases. This is cause by the inflammation which can lead to scarring and obstruction of biliary ducts. Serrapeptase helps remove scar tissue and so doe HSP70. Also using anti-inflammatory herbs helps.

http://www.crohnscolitisfoundation.org/resources/liver-disease-and-ibd.html

https://inflammatoryboweldisease.net/symptoms/complications/gallstones/

https://kresserinstitute.com/little-known-connection-leaky-gut-gluten-intolerance-gallbladder-problems/

This is the oddest part about IBD and other inflammatory diseases. TMAO is low in those who have an intestinal inflammatory disease. Most have too much of the bacteria that produces TMAO but those with IBD have too few.

https://www.ncbi.nlm.nih.gov/pubmed/26160437

This is a list of gut bacteria that increase TMAO consuming choline will increase these bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453578/

https://lpi.oregonstate.edu/mic/other-nutrients/choline

https://draxe.com/what-is-choline/

Faecalibacterium Prausnitzii has been found to be low in those with inflammatory bowel disease. This causes a dificiency in nicotinic acid which leads to an increase in phenylalamine. This lead to a conditions called phenyketonuria which causes high ammonia levels in the body and can effect many metabolic pathways and cause us to become ill when we eat meat, potatoes or anything else that has phenylalanine in it. A deficiency in Faicalibacterium Prausnitzii also results in high cadaverine and putrescine levels which causes inflammation.

https://emedicine.medscape.com/article/945180-overview?pa=70SvUf61EZjJeh01GcM07cjK0CdaeXT%2FVguJkgES6Vuf4MsXKJuI2VMwKp69ZMinm%2BKlpX80V6KaHMrB8SW%2FFlaycSibeA0Q%2FJsWK%2BpGHzs%3D

https://www.healthline.com/health/phenylketonuria

Our gut bacteria need iron tho thrive but the iron they fortify food with is the wrong type. Iron found in curly dock and burdock root will supply you with iron without causing toxicity unless you have certain liver diseases. If you have iron toxicity lactoferrin will restore iron homeostasis. Curcumine will reduce iron levels in the blood also but do not take it too long or you can become anemic.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491036/

Ghrelin stimulates our appetite and increase stomach acid.

https://www.theunion.com/news/twi/glyphosate-roundup-and-its-link-to-celiac-disease-gluten-intolerance/

Fatty acid and vagus nerve stimulate ghrelin.

https://academic.oup.com/abbs/article/41/3/188/655

https://www.ncbi.nlm.nih.gov/pubmed/29632576

https://www.selfhacked.com/blog/32-ways-to-stimulate-your-vagus-nerve-and-all-you-need-to-know-about-it/

https://thelivingproofinstitute.com/19-ways-to-stimulate-your-vagus-nerve/

https://www.psychologytoday.com/us/blog/the-athletes-way/201607/vagus-nerve-stimulation-dramatically-reduces-inflammation

I had to alternate types of diets until I got things straightened out. I had to do a FODMAP diet first then as I healed I had to switch to a Paleo diet. Then when I had healed enough I was able to fast it took me a while to build up to being able to fast for a day. Some can go longer and it is dangerous for others like those with lysosomal storage issues.

https://paleoleap.com/butyrate-anti-inflammatory-fat/

Hydrogen Sulfide produced by gut bacteria can cause sulfation issues.

https://sibosurvivor.com/hydrogen-sulfide-sibo/

When we have too much hydrogen sulfide being produce by our gut microbiome it will cause us to become constipated.

 https://www.ncbi.nlm.nih.gov/pubmed/28971603

https://www.sciencedirect.com/science/article/pii/S2213007117300485

now you have reached a state that has caused a cycle that is hard to break and results in ulcerative coalititis and even IBS.

 https://link.springer.com/article/10.1023/A:1018867516575

Excess H2S causes low blood pressure and a reduced body temperature. It will slow our metabolism causing us to feel drowsy.

http://www.ei-resource.org/…/gut-bacteria-the-hydrogen…/

The inhibited phosphorylation causes a deficiency in the redox ions needed by many metabloic pathways. Mainly Mg2+, Mn2+, Zn2+ and indirectly Ca2+. So it pretty much shuts cellular function down.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010430/

Not all will get drowsy with the inhibited phosphorylation it may cause NMDA issues which is what happened to me. When this happens and your glutamate levels sky rocket it will fell like your head is going to spit open, you will not be able to sleep and you will experience anxiety.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966912/

This thread is long enough but the can effect the CBS and BH4 pathways which can lead to sulfur intolerance and meat intolerance. Even after correcting this problem you have to heal the gut and get the oxalates down to restore the function of the metabolic pathways.

http://www.talkingaboutthescience.com/studies/Donohue-Sulfoxidation.pdf

Having to many H2S producing bacteria has been shown to raise blood levels of H2S. I could not find studies on the prolonged effects but I have found information on prolonged exposure. It causes sulfhemoglobin which cannot be broken down by the body.

http://www.theijoem.com/ijoem/index.php/ijoem/article/view/482

https://www.ncbi.nlm.nih.gov/pubmed/25237136

https://www.frontiersin.org/articles/10.3389/fped.2018.00098/full

Thiamine and B6 deficiency can cause high oxalates.

https://www.ncbi.nlm.nih.gov/pubmed/3947375

https://draxe.com/thiamine-foods/

the gut and cholestokinin

http://www.yourhormones.info/hormones/cholecystokinin/

https://www.selfhacked.com/blog/good-bad-effects-cck/

Trypsin inhibitors increase cholecystokinin.

https://naldc.nal.usda.gov/download/26115/PDF

Things that raise GABA like , mugwort, wormwood and rooibos reduces cholecystokinin levels. High estrogen levels cause high cholecystokinin levels. High dopamine levels increases cholecystokinin. High levels of cholecystokinin causes glutamate toxicity and NMDA toxicity.

https://www.acnp.org/g4/GN401000056/CH056.html

Potatoes increase cholecystokinin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033477/

If not addressed it leads to autism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628252/

Proprionate is high in Ibs. This strikes me as odd because acetate and butyrate are low in IBS. How can one short chain fatty acid be high and the test dificient?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847229/

https://www.healthline.com/nutrition/short-chain-fatty-acids-101#section1

High proprionate can cause loss of appetite and weight loss.

https://gut.bmj.com/content/64/11/1744

it is from having to high of bacteroides.

https://jb.asm.org/content/jb/134/1/84.full.pdf

This article partially explains the high bacteroides levels.

http://humanfoodproject.com/going-feral-one-year-journey-acquire-healthiest-gut-microbiome-world-heard/

Meat increases bacteriodes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820228/

meat alkalizes the gut so it makes sense that those with IBD may consume more meat which will make them have raised bacteroides levels. This can lead to many health problems.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949257/

Betaine reduces bacteriodes by increasing stomach acid.

https://www.selfhacked.com/blog/tmg-health-benefits/

http://drlwilson.com/articles/TRIMTHYLGLYCINE.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176045/

Snail1 involvement in inflammatory bowel diseases indicates macrophagy issues.

https://www.ncbi.nlm.nih.gov/pubmed/21830269

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0450-z

Macrophagy issue also cause lipogenesis issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108423/

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0450-z

Glycolysis issues are also an indication of inhibited macrophagy and sure enough those with inflammatory bowel disorders have glycolysis issues.

https://onlinelibrary.wiley.com/doi/abs/10.1002/ibd.21388

Macrophagy genes have been impicated in inflammatory bowel disease.

http://www.els.net/WileyCDA/ElsArticle/refId-a0025006.html

Good information from my friend David Anderson.

For people with digestive issues

Hydrophilic colloidal diet

1. Hydrophilic colloids bring about conditions in the stomach during digestion which approach those resulting from the consumption of foods in their natural state.

2.Hydrophilic colloids lessen gastric irritation by absorbing the digestive secretions of the stomach so that digestion takes place within a mass of food.

3. Gelatin, because of its availability, relatively low cost, non-toxicity, adaptability as an item of dietary and its thorough digestibility becomes an admirable hydrophilic colloid for dietary usage.

4. The amount of gelatin to be used in a given case depends on the patient’s needs, but it must be of good quality and sufficient in amount.

5. It has a wide range of usefulness in gastrointestinal ailments ranging from the atonic conditions met in the chronic invalid to the irritating condition presented in gastric ulcer.

In some instances, gelatinized arrowroot powder has been used to achieve similar results.. Arrowroot/pectin, etc… Could possibly be used if oxalates are an issue.

 

https://link.springer.com/article/10.1007%2FBF03010602

 

Medium chain triglycerides improve bile flow and decrease bile reabsorption.

https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2014/06/Parrish-February-17.pdf

https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-018-0267-x

MCTs help heal leaky gut and inflammatory bowel disorders.

https://www.ncbi.nlm.nih.gov/pubmed/27187452

https://www.frontiersin.org/articles/10.3389/fimmu.2016.00290/full

Organic acids help heal the gut mucosa.

https://www.researchgate.net/profile/Ulker_Eren2/publication/282700134_Effects_of_dietary_organic_acid_supplementation_on_the_intestinal_mucosa_in_broilers/links/5649b1d908ae451880af661a/Effects-of-dietary-organic-acid-supplementation-on-the-intestinal-mucosa-in-broilers.pdf?origin=publication_detail

http://www.mdpi.com/2072-6643/9/9/920/pdf

file:///home/homuser/Downloads/nutrients-09-00920.pdf

They recommend glutamate in this. That is not correct because those with inflammatory bowel issues have high bacteriodes and glutamate feeds them which can make things worse. But there is useful information in this.

There is an error in this. Those with inflammatory bowel have high bacteroides which causes a lot of problems. They claim glutamate helps but it feeds bacteroides so would make things worse but I found useful information in this.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622680/

Interesting information on inflammatory bowel disease.

https://www.hindawi.com/journals/mi/2017/6869259/

Those with inflammatory bowel issues are low in biotin which is probably caused by the inflammation inhibiting absorption.

https://europepmc.org/abstract/med/19056639

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129763/

A biotin deficiency causes the inability to break down proteins, fats and other nutrients.

https://www.physiology.org/doi/abs/10.1152/ajpcell.00141.2016

Those with inflammatory bowel usually have low biotin which can cause many metabolic issues. Biotin needs Adenosylcobalamin which is a form of B12 in the body. Some may have to supplement if the body is not converting it.

Adenosylcobalamin helps with biotin absorption and use.

https://www.globalhealingcenter.com/natural-health/adenosylcobalamin-4-facts-know/

Biotin and pantothenic acid compete for absorption and pantothenic acid can inhibit biotin absorption.

https://www.ncbi.nlm.nih.gov/pubmed/9814986

Alkaline Phosphotase is low in those with inflammatory bowel disorders. Lactobacillus Casei increases it and will help with nutrient absorption.

https://www.ncbi.nlm.nih.gov/pubmed/22783049

Before increasing it make sure you know the dangers of too much.

https://www.selfhacked.com/blog/alkaline-phosphatase/

How to increase ALP.

https://health.onehowto.com/article/how-to-increase-alkaline-phosphatase-11707.html

http://www.newhealthguide.org/Low-Alkaline-Phosphatase.html

If you take curcumin once the gut bacteria start getting established stop taking it. It can cause anemia because it chelates iron.

https://www.ncbi.nlm.nih.gov/pubmed/25474287

Cissus stimulates ALP.

https://www.ncbi.nlm.nih.gov/pubmed/25449449

https://examine.com/supplements/cissus-quadrangularis/

High estrogen levels effect bile production. Bile protects the intestines from inflamation.

https://hormonesbalance.com/articles/gallbladder-hormone-balance-connection-mean-dont-gallbladder/

Hormones involved with bile flow.

https://hormonesbalance.com/articles/gallbladder-hormone-balance-connection-mean-dont-gallbladder/

Inhibited bile flow can cause estrogen dominance.

http://www.jbc.org/content/early/2018/06/21/jbc.RA118.001789.full.pdf

This causes a cycle that is hard to break and results in high cck levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756670/

Activation of the CCK1 receptor by estrogen can lead to gall stones.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037422/

Dim3 (diinoylmethane) inhibits the estrogen receptor which should lower cholestokinin levels.

https://www.ncbi.nlm.nih.gov/pubmed/25486199

http://joe.endocrinology-journals.org/content/195/3/393.full.pdf

Things that inhibit Era.

https://www.hindawi.com/journals/omcl/2018/6040149/

They mentioned soy isoflavons in the previous study but it could make things worse.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633874/

ursolid acid that was mentioned is found in the wax on skins of apples , in rosemary and thyme.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379974/

 

These are enzymes and hormones that are usually dis-regulated in inflammatory bowel.

Cholesterols function in bile secretion. Issues with the liver X receptor can cause issues with cholesterol metabolism.

http://www.jbc.org/content/278/18/15565.long

https://www.ncbi.nlm.nih.gov/pubmed/29523554

Olive Oil help resolve liver X receptor issues. But inhibits glucuronidation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521785/

Butyrate found in butter and ghee also help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111843/

High estrogen inhibits sulfation. Increasing UDP-glucuronosyltransferases will reduce estrogen levels.

http://www.jbc.org/content/275/46/36164.full.pdf

http://dmd.aspetjournals.org/content/30/5/564

DHA, oleic acid, and linoleic acid inhibit those enzymes.

https://www.nature.com/articles/srep02903

Foods that increase UDP-glucuronosyltransferase.

http://dmd.aspetjournals.org/content/30/5/564

https://www.heart-health-guide.com/apigenin.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874462/

https://www.selfhacked.com/blog/apigenin-top-11-science-based-health-benefits-apigenin/

Luteiolin is good at increasing UDP-glucuronosyltransferase.

http://secretsofnaturalhealing.blogspot.com/2010/12/luteolin-rich-foods-shown-to-reduce.html

https://www.selfhacked.com/blog/top-11-science-based-health-benefits-luteolin/

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166239

Diosmetin is found in the white parts of citris fruit and dates.

https://pubs.acs.org/doi/abs/10.1021/jf502359x?src=recsys&journalCode=jafcau

https://www.researchgate.net/publication/228115816_Bioactivity_of_Diosmetin_Glycosides_Isolated_from_the_Epicarp_of_Date_Fruits_Phoenix_dactylifera_on_the_Biochemical_Profile_of_Alloxan_Diabetic_Male_Rats

 

 

 

 

 

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