Benefits of threonine.

Written by Lee Stevenson

Threonine

Threonine is needed for collagen repair. Threonine support digestive health by improving the health of mucus in the gut. It is needed for muscle and joint health. Threonine is needed to break down fats in the body. A deficiency can cause fatty liver disease. Threonine speeds up wound healing in the body. Threonine maintains proper protein balance in the body. Threonine is needed for quality sleep. Threonine helps prevent sepsis a deficiency make a person prone to gut infections.

https://pubmed.ncbi.nlm.nih.gov/21622125/

Threonine: The Amino Acid Needed for Collagen Production

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636906/

https://pubmed.ncbi.nlm.nih.gov/17585034/

Why those who are chronically ill isolate themselves.

This is not medical advice if you are ill seek medical attention. Do not treat yourself. I am writing this for educational and information purposed.

Written by Lee Stevenson sorry I am a lousy editor.

Before I get into this I do want to explain what occurs is not your fault and those involved are not completely guilty. In our desire to live a normal life we may hide how sick we truly are. When we do finally start realizing how sick we are those around us will offer very little support or help because we look like we are not ill so they assume that our illness is mostly psychological. They will often times say and do hurtful things that add to our stress and can even make our illness worse. We tend to blame ourselves but for the most part it was not our fault that we became ill. The body is very resilient and has many mechanisms that will compensate for things they are not functioning correctly but it reaches a point that it can no longer compensate and then a person becomes chronically ill. It usually take correcting many things in order for the body to get the upper hand and start healing but the demands made by society now days makes it very difficult to heal. Adrenal hormones are usually highest in the morning so symptoms most likely will be worse in the morning. This is also why nausea that comes with it is often times worse in the morning.

Healing from chronic illness requires an anti-inflammatory diet and once that will reduce oxidative stress. It will also require eating more whole foods and for many they may have to cut back on meat consumption until they heal.

When a person is chronically ill they will isolate themselves. This comes with a feeling of guilt because they may be neglecting responsibilities or even family. This is actually a protective mechanism to prevent increased damage to the brain, heart and even the organs in the body. This condition is known as anhedonia. The brain will shut most emotion off in order to protect the Hypothalamus Pituitary Adrenal axis. The HPA also regulates the limbic system. When the limbic system become affected this starts affecting the heart and can result in death. This occurs from sepsis which can be caused by physical injury, infection, stress, betrayal from someone we love, loss of someone we love, trauma, toxins, vaccine injury and many drugs can cause it. The cause of this is because when a person is chronically ill their bodies get stuck in a fight or flight mode. If the issues causing the illness are not correct the HPA and limbic system can become damaged which can be life threatening because they regulate the heart and blood pressure. This also effects a person glucose levels so they will frequently have bought of low glucose levels which will cause nausea, flushing and weakness.

Because the HPA and limbic system function together healing the HPA will help to heal the limbic system.

When this occurs and the brain is still calling for adrenal hormone because the body is still in a state of injury it will start effecting the person emotions. They will start having mood swings, they will start taking more risk in order to try and increase adrenaline. Often times there will be severe muscle twitching or muscle spams or severed charlie horses.

The brain disconnects emotion to prevent further stimulation to the HPA. I found it strange because I experienced this but I still felt the love for others. So I felt guilty I was not there emotionally for them but when I tried I could feel it effecting my health. When the HPA axis is over expressed it increases expression of the limbic system which damages the heart . This causes a loss in blood flow to the extremities and a person will start experiencing ankle swelling, liver and kidney problems which can cause swelling in the face. Nerve damage will occur because the heart is beating irregular so the hands and feet and even some organs are not getting the blood they need.

The limbic system is regulated by the HPA axis. So when they HPA axis is affected so is the limbic system. Symptoms of limbic dysfunction are chronic fatigue, myalgic encephalomyelitis (chronic fatiogue the overwhelming desire to sleep), extreme neurological sensitivity, or heightened sensitivity to pain, chemical and mold sensitivity, a variety of chronic pain, anxiety like attack which will cause rapid breathing, systemic inflammation and POTS. Loss of motivation, impaired short term memory and when it gets more severe loss of long term memories, sever mood swings, it also effects our blood pressure, endocrine system and thyroid hormones. Digestion can be severely affected for each it is affected differently but often times it results in frequent constipation and malabsorption of nutrients especially vitamin B12 and the oil soluble vitamins like D, E and K.

I kept thinking if I just push through this it will get better and I would try to force myself to interact with others and to do things I felt I needed to do like mowing the grass or clearing the driveway of snow. This would result in me having dizzy spells for days because of the damage that had occurred to my heart.

Sometimes it would cause me to get so sleepy that I could not stay awake and I would sleep for days. If I fought the sleep my health would rapidly decline and I would get to the point that I couldn’t even get out of bed to eat or get a glass of water I would have to crawl to get them.

Because the illness cannot be seen many would make unreasonable demands on me. I tried to tell them how ill I was and they would brush it off and even say mean things to me like “you need to suck it up and be a man” or “you need to stop being so lazy”. The emotional hurt that put on me contributed even more to my being ill because the emotional pain added to the stress on the HPA so I would become even sicker.

The links to the studies below show the things that occur when a person is chronically ill. This is the symptoms of someone who’s HPA axis and limbic system has been pushed to the point that it start severely effecting their health and possibly end in death if not treated and not given enough rest.

The first symptoms a person is near HPA and limbic collapse is they will be extremely wired but also be very tired.

Severe muscle fatigue or muscle aches, severe sleepiness and difficulty waking, dizzy spells especially when a person goes from resting to standing. These are not your normal dizzy spells that occur when standing to quickly but they will last for a very long time. A person may lose their libido, gain weight and have hair loss. There may be nausea in later stages because it takes a lot of energy and even for the heart to digest food. When this happened to me I could no longer eat solid food I had to puree it and sometimes that was too much and I could only drink juice. A person may have mood swings from trying to maintain a normal life while their body is trying to tell them to rest. It also causes increased brain swelling adding to the HPA and limbic system dysfunction. Constantly low body tempeture is a sign the HPA has been damaged this will also effect hormone levels and thyroids.

When the limbic system gets impaired a person will first start to experience short term memory loss. When it gets more severe they will start losing long term memory. Mine got so bad I could not remember my name or where I lived sometimes. Symptoms that the HPA is over activated are anxiety, mood swings and severe depression and irritability.

When a person is chronically ill the fight or flight mode their bodies are stuck in will constrict blood vessels and increase heart rate in order to prepare the body for what it perceives is a threat. If the health issues are not correct the heart will become damaged and then there is a loss of proper blood flow. If a person reaches this stage of illness their body and brain starts going into survival mode. When the chronic illness is severe the body knows things are starting to fail. It will induce panic and rapid breathing will occur. In later stages when things get very severe seizures will occur. Because this effects the body tempeture a person will become very sensitive to cold.

Sadly even though man studies show it is not a state of mental illness but a part of their chronic illness society and modern medicine list it as a mental illness and tries to treat it with drugs often times making the chronic illness worse. Family will try to push a person suffering from this into living a normal life or offer very little help which usually contributes more to their illness.

When a person has experienced anhedonia and recovered they can be easily set back and become ill again. It takes the HPA axis and limbic system months and even years to heal. The problem I had is as soon as I felt well again I would start to act like life was normal and would set myself back.

To recover from anhedonia you must address the cause.

If a person has experienced a traumatic event loss of a loved one or betrayal by a loved one they will need to learn to stop dwelling on it and get past it and stop letting it effect them emotionally because that translates over to physical illness. If a person dwell on the loss of a loved one or a traumatic event it will keep the body in a state of fight or flight and the HPA and limbic system will continue to decline.

If the illness is caused by physical illness then the person will need to address the cause or causes because often times it is caused by many things coming together whether it is trauma, along with vaccine injury or a number of other things that can combine to cause the HPA and limbic system to become damaged. There are many forms of chronic illness that can lead to this condition but the biggest causes now days is tick born illness or other infectious diseases because vaccines and GMO foods have weakened many people immune system along with the many medication they are pushing now days especially fluoroquinolones.

This is not something a person can recover from over night. I for the most part have healed but stress still sets me back. I can usually handle physical exertion with no problem until a stressful event has occurred. When this occurs it sets me back physically because it takes the brain months and sometimes even years to heal . Since the HPA and limbic system are located in the brain they do not heal as quickly as the rest of the body. So in order to heal on top of addressing the health issues we need to do our best to avoid stressful situations. We need to learn to view things more positively and get over things that have stressed us much more quickly. Sometimes we may need to talk to a psychiatrist to help us resolve things from our past including the trauma, neglect and out right cold heartedness we experience from those we love.

I will try to explain what is happening.

If we do not correct our HPA axis and limbic system our hormones cannot return to normal because progesterone gets shunted to make adrenal hormones. This is not as noticeable in men but in woman they can develop PCOS or some other hormonal problems. If this is not corrected a person could develop interstitial cystitis. The hormonal problems caused by HPA over activation is a double edged sword. We may be very tired and very fatigued but may struggle to sleep or wake through the night often. We will develop severe night sweats. We may experience bloating in the gut. Women will experience issues with menstruation and may grow excess facial hair. Men and women can experience hot flashes. This comes from the hormonal imbalance and the low glucose levels. Some may experience weight gain, lowered libido and sugar cravings. Processed sugar increases HPA activity so would make the symptoms worse. There will be migraines or severe headaches.

If the upregulation of the HPA and limbic system continues the adrenals and limbic system becomes severely damaged causing them to function improperly the body will lose it’s ability to produce adrenal hormone. This is called NeuroEndometabolic stress response (NEM). This puts the adrenals at the forefront of this anti-stress battle. The body puts adrenal function ahead of other things because it is needed to maintain proper function of the cardiovascular system if it fails then we could die. This is why the body starts shunting progesterone and using it to produce adrenal hormones when all other sources to produce adrenal hormones have been depleted it is one of the bodies last ditch efforts to survive. Many medical professionals will throw substitute hormones at someone which often times mask the symptoms while making the person sicker. When it has reached this point then the recovery process will most likely take years instead of months. Progesterone is needed to protect the body from the oxidative stress causing properties of estrogen so when it becomes depleted oxidative stress increase adding to the body be in a state of fight or flight mode. The liver and kidney become congested and their function becomes inhibited causing them to swell and they will start to develop fibrous tissue farther decreasing their function. Until the adrenal issues and the issues causing them to occur are addressed this process will continue to occur until there is renal failure. This is why when a person is experiencing HPA dysfunction they will have pain in the lower back on their side. Over consumption of B vitamins can also cause that type of pain because the body can store B vitamins and over consumption of certain ones can start to damage the liver and kidney. If progesterone is added when this is occurring it will speed up the rate the renal system is being damaged. In males the low progesterone levels cause a loss of sperm production. Low progesterone levels causes heart arrhythmia, POTS which can result in stroke or heart failure. Progesterone is needed for connective tissue repair in the body. When levels are low the gut can become damaged, the joints can become damaged and even start to leak, when very severe the bladder will get damaged.

There is a chemical released called phoenixin and reducing it can help but we still need to address the causes of the HPA and limbic system dysfunction. Symptoms of high phoenixin levels are poor memory or memory loss, a lack of showing emotions, a person may start seeking adventure or start doing dangerous things in an attempt to increase adrenal hormone levels, if phoenixin levels get to high a person will lose their ability to think logically. If phoenixin levels remain high for an extended period of time a person will experience severe itchiness in the skin. A person with high phoenixin level will be prone to retaining fluids especially in the face and ankles. Phoenixin causes the secretion of many hormones which can farther contribute to the hormone imbalance. It also stimulates the HPA axis. To reduce it we must reduce inflammation, if we have leaky gut or gut dysbiosis we must correct it. If we have tick born illness or mycoplasma infection or some other infection it has to be addressed in order for the HPA and limbic systems to heal. Avoiding processed foods and foods that are not organic is a must because glyphosate works synergistically with the BT Toxins in GMOs and cause chronic illness. Phoenixion can cause a persons body temperature to remain lower then normal. Stress, physical trauma need to be avoided as much as possible in order to reduce phoenixin levels. Phoenixin also causes nerves to become much more sensitive and the pain can cause increased HPA and limbic activity. High phoenixin levels increase the markers found in interstitial cystitis so it will cause interstitial cystitis to become much worse. Phoenixin causes high insulin levels and low glucose levels it causes insulin resistance. Phoenixin causes oxidative stress so antioxidants are a must. It inhibits the NRF2 pathways so it may be necessary to take an NRF2 activator in order to heal. Remember balance is the goal we need some oxidative stress and inflammation to maintain our health and to protect the body from cancer. Palm oil helps to reduce phoenixin.

We need to heal the whole body including our way of handling stress because it cannot be avoided now days. I will attempt to explain what happens to the adrenals before I get into healing them. The constant HPA up-regulation will eventually wear the HPA and limbic systems down. They will no longer be able to keep up. Adrenal hormones are needed when we exert ourselves, when we deal with stressful situations. Because our adrenals and limbic system is damaged they will not be able to keep up. When this occurs heart failure can occur if we try and push ourselves beyond what our bodies are capable when it has reached such a point. I have had many friends while healing who pushed themselves too hard because they thought they were well and they either severely set themselves back or even died. So as we are healing we need to pay extra attention to our bodies and know when we need to take a break from either stress or physical activity.

It is very very important to stay hydrated because dehydration adds to the adrenal fatigue because it an put the body in a state of fight or flight mode also. Electrolytes are also very important to support the HPA axis. A good way to restore electrolytes is to take some water and add lemon, 1/8 teaspoon of cream of tartar (be cautious get aluminum free, aluminum damages the HPA axis and the limbic system), also add organic raw honey which has many healing properties. Cholesterol is needed to produce all hormones in the body especially adrenal hormones. Deficiencies in B vitamins damages the HPA and limbic systems. This is very common now because processed foods are low in B vitamins and the farm chemicals used on our crops causes them to be deficient in B vitamins. Adding to the problem is the fact that much of the farm land has been over farmed adding to the nutrient deficiencies. It is best to buy organic and buy from local farms when possible. Magnesium, zinc, iron, copper, chromium, vanadium are needed for HPA and limbic system health. If you take too much zinc , iron, copper , chromium , vanadium it will have the opposite effect and start damaging the HPA axis. Excess iron can increase oxidative stress. Vitamin C is needed in high amounts when the trying to heal. Taking too much vitamin C can cause oxalates to form and can destroy red blood cells so if you take vitamin C do so wisely. I found liposomal was the one I reacted to the least. I had interstitial cystitis and reacted severely to anything that contained vitamin C. Once my adrenals started to heal my interstitial cystitis started to heal though I had to heal many other health problems to stop the damage that was occurring. The sesquiterpines found in myrrh and frankincense have been found to work very well for increasing oxygen levels around the receptor sites involved in the HPA and limbic systems which speeds up the healing time. Omega 3 fatty acids have been found to speed up the recovery of the HPA axis. I found alternating the types of Omega 3 was much more effective. Some may react to coconut oil because it kills many types of pathogens including mycoplasma. The endotoxins released will add to the body being in fight or flight mode so when a person start killing infection they should do so slowly and strengthen the body and detox systems before doing so. Avoid processed sugars , because the upregulated HPA axis will cause low glucose levels a person may crave sugar and salt. Sugar will add to the HPA dysfunction because it causes systemic low grade inflammation which also puts the body in a state of fight or flight mode. We need complex carbohydrate like those found in roots , inulin which is non digestable fiber,grains, seeds, legumes, beans, vegetables and nuts. Those with leaky gut may have to avoid things that contain lectins until there gut is healed. We need lectins but when the gut is too porous the lectins will enter our blood stream and will cause systemic inflammation. This also can cause immune dysfunction which also causes the body to get stuck in fight or flight mode. Things that contain the highest level of lectins is milk, wheat, tomatoes and beans. The complex carbohydrates help keep the blood glucose levels stable because when they are low the body will also go into fight or flight mode. The most important B vitamins are B6 and B12. Avoiding inflammatory foods like Omega 6 fatty acids is very important.

The body goes into fight or flight mode during infection for many reasons. Often times it causes systemic low grade inflammation and oxidative stress which causes the body to go into fight or flight mode.

Our stomachs contain microbes called our microbiome. Those microbes modulate our genes and health. A deficiency in one microbe can cause many health issues. Those microbes consist of phages, viruses, bacteria, fungus and even amoeba. Most in the industrialized nations are more prone to chronic illness because the toxins, medication, farm chemicals in foods, stress, vaccinations altering the immune system leads to an imbalance in gut microbes, processed foods, consumption of too much of one specific type of food instead of getting a variety causes a loss of many of the microbes in our guts needed to maintain a healthy immune system, prevent inflammation , regulate our glucose levels and protect us from infection. Part of the reason infectious disease is rampant is because many species of microbes are now extinct in those who live in the industrialize world. For those who do not have a way to replace those microbes they have to permanently adjust their diets to compensate for the microbes that are missing which only partially addresses the health issues caused by a lack of certain microbes. It is very difficult to get those microbes from our environment now because the chemicals and toxins being put in our soils have killed many of the beneficial microbes in the soil which is how many of our microbes that maintain our health are acquired. We also inherit our microbes from our parents. The fathers microbe heavily influence the makeup of the mothers so the fathers microbes can effect the health of the whole family. Achieving health should involve the whole family restoring microbial balance in their gut. If we have an overgrowth of certain microbes or a deficiency in some it can cause systemic inflammation, autoimmune disease, nutrient deficiencies because most of our vitamins are produced by our microbiome and we only get some our our vitamins from food. Even biotin is created by our gut microbes. All of these can lead to the body being stuck in fight or flight mode which will cause HPA and limbic dysfunction. Now add to the fact that all this can make the gut more porous which will cause food particles that would not normally enter the blood stream to enter our bodies. This causes a person to start developing a variety food intolerance and allergies. The regulation in the immune system will also cause the HPA axis to become dysfunctional. As this goes on and our environment becomes more toxic chronic illness is becoming more and more rampant. In the U.S. 80% of the population is said to be on a medication of some type. The sad part of that many studies have shown that up to 80% of the benefits of medications are based on the noocebo effect . In other words because the person has changed their negative state of mind based on their believe the medication is healing them they start healing showing our state of mind is a very part of the healing process. The medications all come with side effects that are very damaging to the body so they end up with a new set of health problems after taking the medications , especially antibiotics which dramatically alter our microbiome. If a person does not heal their gut they will be fighting a losing battle and the gut is always effected during chronic illness.

Things that can help restore the HPA and limbic health.

There are herbs that can help restore health of the HPA and limbic system once the causes are addressed these can also be taken as a person is addressing those issues to help reduce the damage. For example grape seed extract improves blood flow reduce inflammation and histamines which will help reduce the bodies need to be in a fight or flight mode to survive. There are adaptogenic herbs that help support adrenal function while reducing stress hormones these are called adaptogenic herbs. Some of these are ashwangha, rhodiola, bupleurum, rhemannia, mace root and kudzu root. Herbs that relax also help to reduce stress hormones, some of them are lemon balm, peony, rooibos, and mugwort.

Exercise in moderation helps to improve HPA and limbic health but be very aware of your limitations because if you over do it you can set yourself back not just for days but for weeks. Even someone healthy could damage their HPA axis if they exercise excessively. Excess exercise can cause progesterone levels to decrease.

Studies have shown that meditating on positive things and happy things can improve HPA health. I meditated on things I liked doing or even on just laying in a field with flowers. Taking the time to enjoy nature and looking at the stars has been shown to improve HPA health.

Positive social interaction has been shown to be good for HPA axis once our adrenal health is well enough we can interact with others. If we attempt to do this before we have recovered enough it could actually do the opposite and increase the time needed to recover. Negative interactions have been shown to have a dramatic effect on the HPA axis. When I say negative interactions I am speaking of those that involve yelling, fighting, all out bad behavior that could negative effect others. Even gossip has been shown to have a negative effect on the HPA axis. I never listened to gossip so I was protected by this one because I always thought if they are saying that about them when they are not around what are they saying about me when I am not around?

We have to remove ourselves from stressful situation that we can remove ourselves from. For example I never liked arguing so if a person started yelling and arguing I would not discuss things with them until they started being respectful and listening to me as well as I listen to the. The bible says “be quick to listen and slow to speak”. I was also protected by the stress of this because I would rarely engage in someone who behaved this way until they started behaving rationally. I used bible principles in guiding me on who I should and should not associate with , this meant some family who caused me stress I had to start cutting out of my life in a biblical way. Though the bible may consider them a bad association we still have familial obligations so we cannot leave them go without something to wear, eat or drink. If they were ill we would still be required to help them. But we would do so in a way we protect ourselves from the stress their life styles could cause us.

Things that cause us stress that are not necessary could be cut down. I had too many belongings, this was very stressful for me. I had to worry about them being stolen. I had to worry about the money to maintain them. I always had a car and a truck. I used to own my own property and it was paid off. I lost that because I could not afford to pay the taxes when I got ill. Reducing my belongings dramatically reduced my stress. Though I really got sad when I lost my house no longer having the responsibility of maintaining it reduced the physical and emotional burden it had been causing which shortened the time it took too heal my HPA axis. I am not saying a person should get rid of their belonging but I am saying to not let yourself get consumed in acquiring them because in the long run it could take it’s toll on your health by having a negative impact on your HPA axis. I have watched many wealthy people die unhappy only to have their wealth go to someone who did not work hard to build it the wealth so they squandered it. This is not always the case but I have seen it happen many times. Since I have gotten ill I am much more aware of what brings me true happiness. I have learned enjoying the simple things in life bring me much more happiness then money and my belongings have. Studies have shown that focusing on the success we have and not on the success we do not have improves brain and HPA health. Studies have also shown if we dwell on past failures then it will have a negative impact on the health of our brains. So we need to keep looking forward and view those mistakes or failures as lessons and move on. Dwelling on them will only hold us back anyways because if we continue to look back how can we move forward?

Participating in bible study and prayer has been shown to improve over mental health and HPA health. Doing good things for others has been shown to improve HPA function. Learning not to hate and not to hold grudges but learning to forgive protects the HPA axis from the negative hormones produced by those. Acts of kindness produce hormones that have been shown to improve HPA and Limbic health.

There is stress that cannot be avoided. We need to do our best to train our minds not to react to harshly to it and try our best to maintain balance and composure so that our adrenal levels do not climb. We have to learn to let things go we can do nothing about and not dwell on the. How we react to stressful things also can effect our HPA and limbic systems negatively. For example often times people will view unexpected events or obstacles as a negative thing. I have retrained my mind to view them as challenges that will build my mental endurance, wisdom and knowledge. I have found this prevents me from getting over excited about things that occur that I cannot control. Now as for the negative emotional things that occur I am still working on this and it still has a dramatic effect on my HPA and limbic system. For example I do not deal well with being falsely accused of something and it causes my adrenal hormones to go through the roof. I have been working very hard to learn to deal with this because when it occurs it sets me back pretty far.

The brain also needs to be repaired. The brain cells can restructure themselves and can even grow new cells. When we learn new things this stimulate new brain cell growth and restructuring. This is called neural plasticity. The more we use our brains the faster it becomes at doing this. This can also improve HPA and limbic health since they are a part of the brain. This is why developing new hobbies or learning new skills can improve limbic health. Hobbies and learning new skills have also been shown to help people recover from trauma much more quickly. Hobbies or skills that require the use of the hands have been shown to dramatically improve brain health. Playing games including card games improves brain and HPA health. Getting workbooks that involves answering questions or doing word puzzles improves brain health.

Self-acceptance or self love is very important. I struggle with this one but I have been working on it. We need to learn to do acts of kindness towards ourselves. I have lived my life always being needed by others and never had time to focus on myself. I either forgot how to love myself or never knew how until some friends pointed out I did not do acts of kindness towards myself and had difficulty excepting when others did acts of kindness towards me. Another part of self-acceptance is not comparing our self image of who we are or our body image to others. We need to learn to be happy with our bodies the way they are. Studies have shown that dwelling on body image in a negative way has a dramatic negative impact on the health of the brain , HPA, and limbic system. We need to accept our bodies for the way they are. Many of us may struggle with this, I am one of them because I used to be very muscular and I also got damage by fluorquinolone drugs which caused me to lose some of my teeth and it also cause bone loss which made my teeth become crooked. I am trying to to dwell on those things because I can feel it effecting my health. I am trying to apply what friend has stated to me “we need to stop worrying about those things because we have much bigger fish to fry” . In other words we need to focus on maintaining our health and for many of us trying to make a living while recovering from chronic illness because most forms of chronic illness the government will not give a person disability for.

Quinolinic acid

Quionolinic acid is very damaging to the body, brain and neurological system. It also causes the body to get stuck in fight or flight made through it’s effects on the NMDA receptors . It up-regulates them this can lead to many mental health issues, severe headaches, this causes a person to be sensitive to light glare, very sensitive to sound, difficulty staying focused. The over stimulation of the NMDA receptor cause the HPA and limbic system to be over stimulated. If the high quinolinic acid levels are not corrected it can lead to severe neurological damage, Alzheimer’s , schiszophrenia, and dementia. A person could also develop Bell’s Palsy like symptoms. This can also happen when the HPA has been stuck in a state of fight or flight.

Quinolinic acid is a metabolite of tryptophan. Quionolinic acid is formed during the bodies production of niacin which is the final step in the kynurenine pathway which is needed to produce energy for our cells. When this process has become disrupted by oxidative stress, toxins, systemic inflammation, emotional stress or trauma, infection, gut dysbiosis, leaky gut, vaccine injury, aluminum build up in the brain and body, heavy metal, autoimmunity, high histamine which can also increase HPA axis over activation, eating too many processed foods especially ones that contain glyphosate and drug injury usually from fluroquinolone drugs.

When quinolinic acid excites the NMDA receptor glutamate increaes , this inhibits the reuptake of glutamate into the cells. This also inhibits the ability to create GABA . The excess glutamate also stimulates the NMDA receptor causing increased activity. This causes even more glutamate to be released. This starts causing brain inflammation, neurological damage and can damage the blood brain barrier. If it become severe enough the brain may start leaking fluid bay the base of the skull and it may also leak out through the nasal passages. This causes sever swelling at the back of the neck and severe pain. When the quinolinic acid levels are high a person will experience severe headache that may make it feel like their head is going to split open. The body has another way to produce quinolinic acid and it is effected by the same things kynurenine pathway is. This adds even more to the quinolinic acid being produced. The alternative pathway is not found in the brain but with the blood brain barrier now leaking the quinolinic acid produced by the 3-HAO pathway can now enter the brain also increasing quinolone levels even farther. Those who have Lyme disease almost always have high quinolone levels because it creates the perfect storm needed to cause this to occur. The destruction of nerve cells that occurs causes iron to be released. The increased quinolinic acid production even more. Since the 3-HAO pathway is producing energy for the rest of the body which covers a much broader area it produces quinolinic acid at 80 times the rate that they kynurenine pathway does. This farther adds to the inflammation and oxidative stress causing a positive feedback loop that can be very difficult to break.

Since the blood brain barrier has been compromised it let many things enter the brain that would not normally be able to enter the brain including infectious agents, and toxins. This adds even more to the brain inflammation and damage.

Metabolic issues and infection that cause high ammonia levels or acidosis can also cause the blood brain barrier to become porous setting of a cycle that would cause quinolinic acid levels to become very elevated. Another thing that increases quinolinic acid is brain injury.

Oddly depriving oneself of tryptophan can actually cause the quinolinic acid to increase. A person with high quinolinic acid levels will usually be very sensitive to the consumption of gluatamate, glutamine and MSG.

These are some things that will help reduce quinolinic acid levels. Antioxidants especially selenium helps to reduce quinolinic acid, P5P the bioavailable form of B6 help reduce quinolinic acid. Vitamin B2 is also needed. A ketogenic diet with complex carbohydrates reduces quinolinic acid and increases kynurenic acid production which is very healing. Certain proteins will inhibit the formation of kynurenic acid. These would be glutamine, glutamate , alanine, tyrosine, phenylalanine, aspartate, leucine, methionine and isoleucine. A person with high quinolinic acid levels may be sensitive to those proteins because of the inhibition of the kynurenic acid. This does not mean that a person should avoid protein but they should avoid consuming those ones in large amounts. When all nutrients needed for the conversion of tryptophan consuming it will increase kynurenic acid.

A-lactalbumin increases tryptophan , and serrotonin synthesis and release in the brain.

Retraining the limbic system.

After being chronically ill for an extended period of time the limbic system needs to be retrained in order to get it out of the fight or flight stage it is stuck in. Things that heal the brain also heal the limbic system. As mentioned earlier the brain can produce new cells and restructure old ones. For example it has been found if a person acquires a new job and their old skills are no longer needed but they are learning new skills the brain will grow new cells and restructure old ones that it is no longer using for the old job and old skill to accommodate for the new skill and memory needed. This also stimulates healing throughout the brain. By retraining the brain we are getting the brain to rewire the neuronal pathways in the brain that are associated with the maladapted stress response.

Studies have shown that past trauma can cause negative epigenetic changes so we need to learn to think positively. Not only that but the trauma our parents experienced can cause negative epigenetic changes that can be passed to the children. Those who have had these types of issues will take longer to heal and will have to address those negative epigenetics that were inherited in order to heal. This involves teaching the brain to react positively to things and teaching the brain to remain calm as much as possible this will slowly make epigenetic corrections so the persons body will not be instantly in fight or flight mode.

Things that also retrain the brain and repair it also repair the limbic system for example positive social interaction, meditation on positive things, exercise in moderation. For those who are chronically ill only do what your body will allow if you push too hard you will not only set yourself back but you could cause increased heart damage and even experience a stroke. Dwelling on our day and picking out the positive things that happened out of the day and dwelling on those have been shown to improve limbic health. Also as we heal reintroducing ourselves to stress slowly and as we do learning to deal with it more positively or reacting less negative to it will help restore limbic health. Constant negative thinking rewires our brain and nerves to be more sensitive to pain and causes neurodegeneration. I had to learn to avoid those who think negatively and talk negatively about certain things all the time. I am not talking about those who vent and then react to the situation by working to correct it but I am talking about complainers who just keep complaining and do nothing about it. These ones can start to affect us negatively and cause our brains to rewire in a negative way.

All the things that affect the brain also affect the lymbic system for example over exposure to blue light at night will decrease melatonin which has a negative impact on the health of the whole body. Earth grounding has been found to restore the bodies voltage back to what it should be and restores health to the whole body. Avoid exposure to EMFs as much as possible. Any insulin issues or glucose issues need to be addressed. Reduce exposure to toxins as much as possible. Many things we use are very toxic for example bleached paper products contain dioxin which is very toxic to the body, I still see many cooking in aluminum pains and aluminum is very difficult to remove from the body. If a person has mercury fillings it is very important they find someone who knows how to properly remove them.

Avoiding processed foods as much as possible helps a lot even ones that are organic are fortified with folic acid which is man made and toxic to the body. Folate is natural and is not toxic to the body.

If a person is experiencing sleep issues it is very important that they work to correct these because the brain , HPA axis, and limbic system cannot heal if we are not getting REM sleep or if we wake often through the night or do not get enough sleep. From my body being stuck in fight or flight mode it had forgotten how to sleep I had to work very hard to retrain my body to sleep.

Anti-inflammatory foods.

Meats and foods from animals feed grain should be avoided it has been found they have a different nutritional content and they are inflammatory. So when looking for foods produced from animal products look for ones that have not been fed grains but have been free range or pasture raised this included eggs. Farm raised sea food is inflammatory because of the foods they are fed and the environment they are raised in causes increased stress which makes consuming them inflammatory. Avoid things that contain transfats they are extremely inflammatory. Transfats or foods that contain them will state they contain hydrogenated oil. Also processed meats are very inflammatory. GMOs should be avoided because the body reacts the same way to the BT Toxins found in them as it would if a person had food poisoning. Artificial sweeteners are not only inflammatory but they also damage the liver and kidneys and promote obesity. It is very important to eat organic because the toxins sprayed on conventional grown foods do not only cause inflammation and oxidative stress but they cause many types of chronic illness . This is why obesity and heart disease has become epidemic in the industrialized world.

So the anti-inflammatory foods I mention should be from pasture raised animals, wild caught or free ranged. Eggs are anti-inflammatory, fish, fruits and vegetables especially berries. Calciferous vegetables in moderation, over consumption can have the opposite effect. Squash pumpkin and melon is very anti-inflammatory. Olive oil , avocado oil and coconut oil are very anti-inflammatory. Fish oil is anti-inflammatory unless it is old then it becomes inflammatory. When I buy fish oil I make sure it is guaranteed fresh and I make sure it contains lemon and I refrigerate it to prevent oxidation.

We need to learn to seize control of our thoughts and be more aware of when we are thinking negatively or reacting negatively so we can retrain our minds to respond in a way that would not effect our health. We must try our best not to react to negative circumstances especially ones we cannot do anything about. We also must retrain our minds to respond positively because if we could do something about it the increased HPA up-regulation will cloud our thinking and it inhibits the ability to think logically. This is why many companies especially the pharmaceutical industry and the media induce false fears in people and then give them false hope because inducing fear causes a person to lose the ability to reason and think logically. If a product truly worked they would not have to use deceptive tactics to sell their products.

Training the brain to respond appropriately.

Some of the things I mention here I myself am still working on. Once our HPA and limbic systems have healed enough we can endure some stress we need to start meditating on the stressful situations we know cannot be avoided and will arise. We need to meditate on how we can respond in a way it will keep things from getting more stressful and when it cannot be avoided how we can respond in a way it will not cause an increase in activation of our HPA axis. If we are dealing with people who cause us stress we need to handle it in an appropriate way. The bible has the best advice for handling things like that. Sometimes it may involve cutting certain people out of our lives the bible has advice on when that is appropriate and when it is not. Some will be unconcerned about your health issues and how the stress they cause you effects your health. When appropriate and possible it is best to avoid such ones because it will dramatically increase the time it will take you to heal. I am dealing with this now and often times experience many set back but at the present time I have no choice but to learn to deal with it in a way that will not negatively impact my health until I find a way out of my present situation.

How we breath effects our HPA axis and brain. When we are stuck in a state of fight or flight our breathing will become more rapid. This increase the upregulation of the HPA even farther. In order to train the body not to do this we need to learn to breath differently when that happens. Breathing in through the nose deeply while pushing the stomach out next breath out through the mouth slowly. This will increase our oxygen levels and help break the fight or flight response. Only do this about five times because if you increase oxygen levels too high it can cause dizziness and you could even pass out.

Developing a core believe system so we can make clearer boundaries and know when to make our yes mean yes and no mean no retrains the brain to react to stressful situations ion a way that the HPA does not get activated. For me learning the bible and writing it on my heart has helped me a lot, it has given me very clear boundaries that I will not cross or leave others cross. This has prevented me from having to rely on my own understanding and wisdom and has gotten me through some pretty rough times.

We need to learn to word things in a more positive light even negative things that have occurred when possible. This is one I am still at the beginning stages of learning.

Massages help to retrain the limbic system and also trains the body to relax.

We have to stay active if we are healthy enough to prevent our minds from dwelling on negative things. If we are bed ridden we need to develop a hobby we can do while we are healing that will keep us busy or find things we can do while we are bedridden. Used it for an opportunity to read about and learn new skills which I have been able to apply and teach others to help them learn to heal. Also reaching out to others and teaching them to heal helped to prevent me from dwelling on negative things too much.

Engaging in small talk and taking and interest in others heals the brain and limbic system. It also stimulates new brain cell growth.

Memory games improve brain health and stimulate cell growth. Thing like memorizing number, or having someone give instructions and then repeating them back to them helps to stimulate brain healing and brain cell growth.

Taking words and finding words that have similar or the same meaning

Learning a new language improves brain health.

We need to be mindful of ourselves which means we become aware of our thoughts but do not judge ourselves. If the thoughts are ones we should not have instead of judging ourselves we should dwell on what we will do to change our thinking and prevent those thoughts in a good and positive way.

Learning to dance or play music has been shown to improve brain health and limbic health.

https://www.brainandspinalcord.org/faqs/abi/what-happens-if-the-limbic-system-is-damaged/

Is a Limbic System Impairment Hijacking Your Health?

https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-018-1983-5

https://pubmed.ncbi.nlm.nih.gov/33229033/

https://pubmed.ncbi.nlm.nih.gov/33179588/

https://pubmed.ncbi.nlm.nih.gov/33169525/

https://pubmed.ncbi.nlm.nih.gov/33145614/

https://pubmed.ncbi.nlm.nih.gov/33118458/

https://pubmed.ncbi.nlm.nih.gov/33079133/

https://pubmed.ncbi.nlm.nih.gov/33163979/

https://academic.oup.com/ptj/article/94/12/1816/2741907

https://pubmed.ncbi.nlm.nih.gov/18465467/

https://pubmed.ncbi.nlm.nih.gov/32215686/

https://academic.oup.com/ijnp/article/23/1/26/5639667

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900047/

Functional Psychiatry: Treating Common Conditions with the Functional Approach

Inflammation is the cause of chronic illness and infection. To heal you must address inflammation.

 

 

Written by Lee Stevenson not edited though. To tired to edit it.

 

This is not medical advice I am posting this for educational and informational purposes.

Inflammation does serve a purpose. It is involved in healing and immune response in the body. But excess inflammation can lead to chronic illness, immune dysfuction, and mental illness. Inflammation and nutrient deficiencies can lead to infection which cause and add to the inflammation and immune dysfunction. Imbalance in B or T cells can cause chronic inflammation, chronic inflammation can cause an imbalance in B and T cells. They are tightly connected to each other. I posted on autoimmunity with information on balancing the immune system. Reducing inflammation is also important to maintain homeostasis if we are chronically ill.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449453/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416069/

There are many types of cytokines in the body and many types of inflammation. If the cause is not addressed it can lead to chronic illness, autoimmunity and chronic pain. Inflammation disables the immune system and many metabolic pathways needed to heal. It can cause us to become prone to infection from microbes that are usually beneficial to the body. Inflammation can lead to cardiovascular disease, diabetes, cancer and death.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785020/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022040/

https://www.abcam.com/research-areas/cytokines-and-inflammation

https://www.achooallergy.com/learning/chronic-inflammation-chronic-disease/

https://www.heart.org/en/health-topics/consumer-healthcare/what-is-cardiovascular-disease/inflammation-and-heart-disease#.WsU7rNMbPLY

T Cell imbalance and inflammation are the commonality in autoimmune diseases this includes interstitial cystitis, arthritis, hardening of the arteries, obesity, lupus the list goes on and on. You must restore balance to the immune system and reduce inflammation to heal.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416069/

If you have sulfation issues or problems with lipid metabolism you cannot heal you need to get them straightened out. Most things I mention I have posted information on things that will help correct them. If we have issues with lipid metabolism then our bodies cannot use cholesterol effectively which effects the function of the brain, heart and digestion. This is a good video with information on their importance.

https://www.ihealthtube.com/video/will-forever-change-how-you-view-cholesterol-and-heart-health

These are my summarized note on metabolic issues. They have to be addressed in order to achieve homeostasis. Many of these issues I posted more detail in other post.

https://iamajuicer.wordpress.com/2018/10/12/my-summarized-notes/

I will mention things that heal the gut but I covered it in more detail in this blog post.

https://iamajuicer.wordpress.com/2018/12/01/things-that-can-go-wrong-in-the-gut-and-how-you-may-be-able-to-correct-them/

Many will take vitamin D3 to reduce inflammation but this can in some instances make things worse. Excess levels of vitamin D can cause high blood calcium levels which can result in oxalate formation. Those who have sarcoidosis which is an inflammatory disease that effects the organs have high levels of vitamin D3. I have seen many develop this when they have gotten and infection. This leads me to believe there are issue with the vitamin D receptor because problems with the vitamin D receptor will make us prone to illness. Those with sarcoidosis should avoid vitamin D until they get the issues causing the high vitamin D levels resolved. This is caused by upregulation of Cyp27b1 enzyme , the high levels of vitamin D inhibit the vitamin D receptor. This results in vitamin D binding to the Pregnane X receptor. This causes bile to be metabolized quicker reducing the amount of bile produced, this also causes issues with lipid metabolism resulting in lipid accumulation in the liver. Many of the symptoms caused by this are common in those with inflammatory bowel diseases. Make me believe there is a common tie. Maintaining our vitamin D levels is important but those with sarcoidosis probably should not take vitamin D3 but if they supplement it should be regular vitamin D like what is found in fish oil.

https://www.dovepress.com/biomarkers-in-sarcoidosis-a-review-peer-reviewed-fulltext-article-CBF

https://www.ncbi.nlm.nih.gov/pubmed/24753153

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060200/

Vitamin D supplementation did not seem to have any benefits in those with sarcoidosis.

https://bmjopen.bmj.com/content/3/10/e003562

https://www.ncbi.nlm.nih.gov/pubmed/11403752

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2535920/

Vitamin A protects against vitamin D toxicity.

https://chrismasterjohnphd.com/2009/04/07/tufts-university-confirms-that-vitamin/?fbclid=IwAR2Izk2mjxQI9kZyEEh7UvWq9IXgYSSVUZiDePoj8whjeqqKINy6ph7Ww00

https://www.selfhacked.com/blog/importance-real-vitamin-retinol/

Leaky gut and inhibited bile production can lead to food intolerances. I posted on correcting these. Food intolerances cause inflammation and autoimmunity if not corrected.

https://kresserinstitute.com/little-known-connection-leaky-gut-gluten-intolerance-gallbladder-problems/

We need to ask ourselves why food sensitivities, food intolerances , gluten intolerance, gliaden intolerance and many other problems that used to be rare are now very common? What is causing the epidemic?

https://chriskresser.com/pioneering-researcher-alessio-fasano-m-d-on-gluten-autoimmunity-leaky-gut/

Antibiotics have been linked to causing all those illnesses and you will see in this post how. Fluoroquinolone is one of the most dangerous antibiotic of all there are people who have been permanently disabled by fluroquinolones. The inflammation they cause to the body and damage is very very difficult to repair. If we do something reckless that cost people their lives we would go to jail. The pharmaceutical industry is frequently falsifying data, ghost writing studies and even paying people to lie about their products safety. The government has often times been caught colluding with the pharmaceutical industry to hide the harm they do. Why the double standard? Why is no one held accountable for the harm they do? Often times their drugs are what sets people up for chronic illness.

https://www.hindawi.com/journals/omcl/2017/8023935/

This is an example of a bad article. The advice may seem good but they mention spinach which if not cooked it will cause inflammatin because it is high oxalate. It needs to be boiled and the water dumped to reduce oxalates. It recommends fermented foods. Fermented foods are high histamine and if a person dealing with inflammation or high histamines eat fermented foods it will cause inflammation instead of reduce it. They also recommend high sulfur foods which normally would be very healthy but those with sulfation issues or gut dysbiosis who have high levels of sulfur digesting bacteria will become sicker and develop inflammation and high oxidative stress levels. I have posted on oxidative stress, and sulfation. Oxidative stress causes inflammation and can lead to cardiovascular disease and diabetes.

https://bodyecology.com/articles/top_ten_foods_that_prevent_inflammation.php

https://www.ncbi.nlm.nih.gov/pubmed/19890624

Increasing T regulatory cells helps with type 1 diabetes. Our gut microbiome regulate our T regulatory cell levels. I have posted on how to increase them. They regulate the health of our whole bodies even our bone health. I have posted throughout my blog on our microbiota and how each one effects our health. T regulatory cells prevent autoimmunity and excessive inflammation.

https://www.hindawi.com/journals/jdr/2013/621693/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762128/

If we do not address our gut imbalance it can lead to B cell lymphoma. We need to increase the microbiome that reduce inflammation and oxidative stress. I posted on other post which ones accomplish that.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718495/

High resistin is blamed for causing diabetes type 2 and cardiovascular disease. Infection, leaky gut and oxidative stress can cause high resistin levels. It is usually an issue in the gut. It can also be caused by zinc deficiency. A person with zinc deficiencies will have a poor sense of taste or smell, a poor appetite, experience weight loss, whites spots on finger nails and night blindness. High resistin levels is actually a symptom not the cause but just like most allopathic medicine they view the symptom as the cause. Resistin helps protect the body from endotoxins. High levels indicate leaky gut or infection. Zinc deficiency also causes high TH17 levels which is common in lupus and other autoimmune diseases. High levels of endotoxins damage the brain.

https://www.spandidos-publications.com/10.3892/etm.2017.4288

http://kjim.org/journal/view.php?number=169805

https://academic.oup.com/intimm/article/22/5/375/730670

https://www.pnas.org/content/112/40/12468

Endotoxemia which can be caused by leaky gut or infection which causes high resistin levels. This leads to insulin resistance.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046838/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715788/

Endotoxins cause the blood brain barrier to become porous.

https://www.ncbi.nlm.nih.gov/pubmed/24604078

High endotoxins cause the body to release inflammasomes which activate Gasdermin. Gasdermin causes pyropoptoses. Instead of the cell dying in the normal way through apotosis which give the body a chance to clear the debris out with pyropoptose the cell erupts spewing material out. If this occurs enough times the body cannot keep up with the process of cleaning debris out and metabolic pathways can become blocked and it can add to the inflammation and toxic burden in the body. It is believed this occurs to control infection. This shows why it is important to heal leaky gut and to get our lipopolysaccharide levels down and reduce inflammasomes. Stimulating autophagy helps reduce inflammasomes. Mitochondrial dysfunction and damage can also activate inflammasome so glyphosate and many drugs especially fluorquinolones can cause this to occur. Arglabia found in species of artemisia inhibit inflammasomes. Resveratrol inhibits inflammasomes. Activating CB2 receptor reduces inflammasomes. I posted on plants that contain cannabinoids that activate CB2.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807999/

https://www.sciencedirect.com/science/article/pii/S2319417017302780

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539988/

https://www.frontiersin.org/articles/10.3389/fphar.2015.00262/full

Since resistin protects us and if you read my post on cholesterol you will see it also protects us, what does allopathic medicine do. They see the resistin as something that needs reduced which would further add to the health problems but that is ok they will find a drug to treat those symptoms also. Allopathic medicine is not about treating the cause but about treating the symptoms. Here is an example here. Resistin protects from the damage of endotoxins and also from the damage statins do. Their solution try to find a way to reduce resistin. Oh great just what a person needs even more health problems.

https://www.tandfonline.com/doi/pdf/10.1586/erc.12.176

Nutrient deficiencies can cause oxidative stress and inflammation.

https://metabolichealing.com/cholesterol-is-powerfully-anti-inflammatory-prevents-free-radical-activity/

http://www.cholesterol-and-health.com/Steroid-Hormones.html

There are many things that cause inflammation and metabolic issues. This results in mold sensitivity. If you are sensitive to mold it is a symptom not the cause. Most mold the body can detox easily until something goes wrong. There are molds that are dangerous but you would have to breath large quantities of them in directly. The white mold that grows on rotting wood that looks like a spider web is one of those molds. Glucuronidation and sulfation are not mentioned in this article but if they are inhibited they also can cause a person to be sensitive to mold. We have to ask ourselves people have lived around mold for centuries and it did not cause problems before. What has changed? Our environment and food is now toxic. Vaccinations damage the body. Our bodies are being pushed to the max when it comes to detoxing.

https://academic.oup.com/rheumatology/article/38/10/978/1783598

https://www.selfhacked.com/blog/the-root-causes-of-mold-problems-msh-sirt1-socs3-and-hypoxia/

In the U.S. over farming and the use of glyphosate has cause nutrient deficiencies. Over farming depletes minerals from the soils. Glyphosate chelates minerals from the soil and is high in our food supply and chelates minerals from our bodies and kill many of our beneficial microbes in our gut. Our microbes produce some of the vitamins we need especially the B vitamins. Heavy antibiotic use can cause us to become deficient in B vitamins from the loss of our microbiome that produce the B vitamins for us. They have started fortifying our food to compensate for the loss of nutrients. The problem is they use a type of iron that the body cannot easily use, many have toxic levels of iron in their bodies now which causes excess oxidative stress and inflammation. They also fortify our food with folic acid which is man made and toxic to the body. Folate is natural but many do not know the difference including many medical professionals. I have even seen research papers incorrectly interchange the use the words folate and folic acid. High levels of folic acid causes cancer and damages the brain. High levels of folate the natural vitamin prevents cancer and protects the brain. Knotgrass increase lipocalin 2 which helps to restore iron homeostasis. Lactoferrin also helps restore iron homeostasis. Lipocalin can be low in malabsorption but is high during infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880510/

https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-015-0129-z

Processed sugar has been found to cause inflammation that can lead to obesity and heart disease. Fructose is much worse then sugar. But when I looked at studies on those products in their natural forms they did not have ill effects. So apparently our bodies were not meant to have them in purified forms. It doesn’t help that most sugar and fructose is made from GMOs and can contain glyphosate.

http://www.jle.com/fr/revues/mrh/e-docs/high_fructose_consumption_combined_with_low_dietary_magnesium_intake_may_increase_the_incidence_of_the_metabolic_syndrome_by_in_273223/article.phtml

GMOs alone even without glyphosate has been found to cause gut inflammation.

https://www.researchgate.net/publication/259716098_A_long-term_toxicology_study_on_pigs_fed_a_combined_genetically_modified_GM_soy_and_GM_maize_diet

https://totalhealthmagazine.com/GMOs/Are-Genetically-Engineered-Foods-Leading-to-Gluten-Sensitivity.html

Our gut microbiota modulate our immune system and are important for the health of all organs including our brain. I have covered it in more detail in other blog post. It is very important to figure out which ones we are lacking and replace them.

https://www.frontiersin.org/articles/10.3389/fimmu.2018.02240/full

The cannabinoid system is important in maintaining our bodies health. Our gut microbiome modulate it. There are many plants that contain them I have posted on cannabinoids.

https://www.ebiomedicine.com/article/S2352-3964(17)30003-8/fulltext

The omega 3 to omega 6 ratio can effect our cannabinoid system. In the U.S. we consume to much Omega 6 . When Omega 6 levels become higher then Omega 3 levels it can have a negative impact on the cannabinoid system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206973/

This is good information on Omega 3 oil.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418048/

Many spices reduce oxidative stress and when cooked with they reduce toxins produced during cooking. This helps prevent inflammation.

https://www.naturalnews.com/045964_oxidative_stress_inflammation_neurodegenerative_disorders.html#

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590813/

https://www.ncbi.nlm.nih.gov/pubmed/22657091

If the NRF2 pathway is blocked or over activated it can lead to excess oxidative stress. I discuss it in my post on oxidative stress. Activating it can reduce oxidative stress but we do not want to over activate it.

https://www.liebertpub.com/doi/abs/10.1089/ars.2017.7003?journalCode=ars&

Mental stresss makes the gut more permeable. This can lead to endotoxemia resembling an infection.This leads to chronic inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432792/

Many spices help reduce oxidative stress and inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618098/

https://www.hindawi.com/journals/omcl/2011/194586/

Using spices when we cook helps prevent the toxins that can be produced while cooking.

https://www.ncbi.nlm.nih.gov/pubmed/20335545

Our food has become very toxic now days if you read my post on GMOs and what they do to the body it is unbelievable they let them feed us those things. Not only that but the additives they put in foods are toxic to our bodies. Something as simple as Ramen noodles are very bad for our health.

https://www.healthy-holistic-living.com/instant-noodles-inflammation-dementia.html

Too many oxalates can cause chronic illness. High oxalates can irritate the bladder and run the liver, kidneys, gallbladder and cause urinary and vaginal irritation.

https://www.alwayswellwithin.com/2010/04/27/high-oxalate-foods-can-trigger-pain-and-inflammation/

https://myersdetox.com/oxalates-their-influence-on-chronic-disease/

https://healinghistamine.com/low-oxalate-low-histamine-diet-the-missing-link/

Symptoms of high oxalates.

https://functionaldiagnosticnutrition.com/top-signs-you-may-have-oxalate-sensitivity/

Oxalates can also cause us to become sensitive to phenols the very nutrients we need to reduce inflammation will now make us ill. They inhibit sulfation which can cause phenols to build up in our bodies. Glyphosate, mercury and vaccine injury can also cause inhibited sulfation. I have posted on correcting sulfation.

https://www.anniehelpsyou.com/blog/item/2-are-phenol-oxalate-sensitivities-causing-your-health-problems

To add insult to injury oxalates can cause kidney stones and gallstones one their own. They also cause inflammation which can inhibited bile flow and cause problems in the gallbladder which can lead to gall stones. Bile is involved in cholesterol homeostasis so when it because inhibited cholesterol and fats in the body become dis-regulated. When bile is inhibited it breaks the balance of the gut up and will cause an imbalance in our gut bacteria leading to dysbiosis or inflammatory bowel diseases.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774219/

Vasoactive intestinal peptide is usually low in those who have malabsorption issues from inflammatory bowel. When low a person will have difficulty gaining weight.

https://www.selfhacked.com/blog/vip-a-potent-anti-inflammatory-hormone-and-natural-ways-to-increase-it/

Hypoxia can reduce the symptoms of inflammatory bowel diseases.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524634/

When lipids become dis-regulated it can cause an increase in eicosanoids which are inflammatory. When this happens healthy oils like Omega 3s become inflammatory and Omega 6 will cause inflammation. So we must address metabolic issues that will interfere with the proper metabolism of fats to reap the benefits of fats. Cod liver oil works very good for reduing eicosanoid type inflammation. I get cod liver oil that has lemon juice which will keep it from oxidizing. Cod liver oil is also good for the brain.

http://www.itmonline.org/arts/lox.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397342/

https://www.builtlean.com/2013/11/27/omega-3-6-9/

https://draxe.com/fish-oil-benefits-health/

Those with inflammatory bowel should avoid saturated fat until they heal. When we have systematic inflammation we need to adjust our diets. Medium chain fatty acids work best when we have inflammatory bowel issues or malabsorption issues.

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(15)00389-7

http://www.itmonline.org/arts/lox.htm

A mistake many make when they have chronic inflammation is they will take high dose vitamin C which increases inflammation when taken at high doses. Also high dose vitamin C causes anemia because it breaks red blood cells down and depletes certain minerals from the body.

http://morelife.org/references/full_papers/14592804.pdf

Luteolin helps with inflammatory diseases. It has been shown to prevent diabetes and heart disease. It is high in cooked tomato skin. It is also found in thyme, watercress, citrus fruits, celery, green peppers, and chamomille tea. It is one of the most potent anti-inflammatory and is very potent at reducing oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490655/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441798/

https://www.selfhacked.com/blog/top-11-science-based-health-benefits-luteolin/

https://www.sciencedaily.com/releases/2010/07/100708141622.htm

This is a list of foods high in luteolin.

https://myintakepro.com/blog/luteolin-rich-foods/

https://www.lutimax.com/news/2017/11/luteolin-rich-foods-to-add-to-your-diet/

If inflammation is not addressed it will lead to chronic fatigue syndrome.

https://www.pnas.org/content/114/34/8914.full

https://www.lymedisease.org/cfs-stanford/

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I have posted on resolving issues with fat metabolism. Fat is very important for protection from inflammation and infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606863/

https://www.ncbi.nlm.nih.gov/pubmed/30034873

This is a list of spices that reduce inflammation. Out of all of them I feel celery, sage, oregano oil and vanilla helped me the most.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590813/

Liver X receptor regulates cholesterol homeostasis which is very important in the regulation of inflammation and preventing infection.

https://www.sciencedirect.com/science/article/pii/S0163725817301900?via%3Dihub

https://www.sciencedirect.com/science/article/pii/S0925443910002991

Excess NOD2 causes inflammation and can damage the renal system. Infection, and leaky gut can cause high NOD2 levels. This increases inflammation in the intestinal tract leading to inflammatory bowel. Our gut bacteria modulate NOD2. NOD2 recognizes our gut microbiome and will not harm it. Excess inflammation can interfere with toll like receptors which can prevent NOD2 from being able to recognize our good gut microbiome. There are gut microbiome that stimulate IL-12 a loss of these microbiome causes a loss of the ability for NOD2 to recognize our good microbiome. Many metabolic issues can interfere with the proper function of NOD.

https://www.kidney-international.org/article/S0085-2538(15)55943-7/pdf

https://www.dovepress.com/nod2-and-inflammation-current-insights-peer-reviewed-article-JIR

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804938/

https://www.nature.com/articles/srep12018

https://www.frontiersin.org/articles/10.3389/fimmu.2016.00367/full

Infection can inhibit NOD2 especially mycoplasma infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316803/

https://www.nature.com/articles/srep08383

I have posted on Heat Shock Protein 70. HSP70 stabilizes NOD2.

http://www.jbc.org/content/289/27/18987.long

HSP is modulated by diet and our gut microbiota.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892289/

Excess inflammation and excess lipopolysaccharide can inhibit NcoR and SMRT which are the checkpoints for appropriate inflammatory and anti-inflammatory response. I have posted on edotoxemia it is very important to get endotoxins levels down.

http://genesdev.cshlp.org/content/23/6/681.full

There are many causes of excess inflammation . The major ones now days is vaccinations and farm chemicals in our foods, especially glyphosate, bt toxins found in GMOs also cause inflammation.

Many illnesses have been linked to inflammation inflammatory bowel diseases, autoimmune diseases, diabetes, cardiovascular disease and many metabolic diseases. Many things that contain the OspA cause inflammation and the OspA disables the immune system. The only way the body can remove the OspA proteins is through autophagy, using and the Heat Shock Protein 70. Inflammation can inhibit those. Many vaccines contain the OspA along with some mycoplasmas, tick born illnesses, EBV and some molds contain it.

https://www.achooallergy.com/learning/chronic-inflammation-chronic-disease/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905709/

Lupus is caused by a type of inflammation. Ironic it is caused by the same type of inflammation that vaccinations and glyphosate cause. Arthritis has been linked to vaccinations.

https://www.pnas.org/content/110/35/E3311.long

https://academic.oup.com/rheumatology/article/38/10/978/1783598

Arthritis is an autoimmune disorder, vaccines cause autoimmunity awful coincidence. Vaccinations can cause a B cell imbalance that alters our gut microbiome, so can antibiotics and glyphosate.

https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-014-0486-0

A list of foods that may help with arthritis.

https://www.rheumatoid-arthritis-decisions.com/Foods-that-boost-glutathione.html

This is a list of herbs that help with arthritis and why they work. Green Tea inhibits many inflammatory cytokine but should be used in moderation. Drinking it in excess can damage the liver. Curcumin reduces many types of inflammatory cytokines but should be used in moderation it chelates iron and can cause anemia. Resveratrol found in grape skins, wine and grape seed extract reduce many types of inflammatory cytokines but those with hepatitis have to be careful it can activate hepatitis.

https://www.mdpi.com/1422-0067/19/9/2508/htm

Paeonia helps with arthritis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108611/

Thungergod vine helps with many forms of inflammatory illnesses but can irritate the stomach and have effects on hormones in the body.

https://www.hindawi.com/journals/ecam/2018/1567463/

Inulin and oligofructose reduces many types of inflammation by increasing bifidobacteria. Those with dysbiosis have to ease into things like this and slowly increase intake as their gut microbiome increase that digest this type of fiber. It takes about 3 months for most types of gut microbes to get fully established. If our gut bacteria are not established then we can get severe bloating and gas from consuming too much. Also in order to get our gut bacteria balanced we need a variety of foods in order to get them balanced. Over consumption of inulin and oligofrutose can also cause dysbiosis by increasing levels of inulin and oligofructose microbes to high causing an imbalance in our microbiome. An imbalance in our gut microbiome causes allergies, inflammation, food intolerances, and autoimmunity.

https://academic.oup.com/jn/article/129/7/1402S/4722577

I have listed in other blog post on the microbiome that protect us from inflammation, from autoimmunity and from infection. They also modulate our genes and keep our organs throughout the body healthy and communicate with various parts of the body and even teach the immune system how to fight infection.

Notice vaccines increase inflammatory cytokines for quite some time.

https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12509

Those with inflammatory bowel diseases are usually low in interleukin 10 and T regulatory cells. I have posted which gut microbes increase those.

https://link.springer.com/chapter/10.1007%2F978-3-662-43492-5_2

https://www.ahajournals.org/doi/10.1161/01.cir.0000052939.59093.45

An imbalance in our gut microbiome cause metabolic issues which lead to inflammatory diseases. I have posted on how to balance the gut microbiome.

http://diabetes.diabetesjournals.org/content/57/6/1470

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087185/

Statins also cause diabetes by there inflammatory effects on the body.

http://diabetes.diabetesjournals.org/content/63/11/3569

Good information for reducing intestinal inflammation. I have a list of probiotics on one of my post that says which microbes reduce inflammation. Many sites are not accurate and some strains they mention actually increase inflammation.

https://www.marksdailyapple.com/naturally-reduce-inflammation/

This is a very good article explaining the inflammatory process when we have an infection.

http://www.biology-pages.info/I/Inflammation.html

Heart disease is caused by endothelial dysfunction which is a result of excess oxidative stress, toxins, excess inflammation and even poor lifestyle choices.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082111/

https://www.texasheart.org/heart-health/heart-information-center/topics/vulnerable-plaque/#.WUl6aVoDs2k.facebook

Inflammation and diabetes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1087185/

Inflammation and pain.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785020/

https://www.abcam.com/research-areas/cytokines-and-inflammation

Infection indicates a health problem. Usually a nutrient deficiency. Infection can cause chronic inflammton.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022040/

Vaccinations cause systematic inflammation which causes neurological damage.

http://www.greatergoodmovie.org/learn-more/science/brain-inflammation-encephalitis-post-vaccination/

https://www.ncbi.nlm.nih.gov/pubmed/15976761

http://www.greenmedinfo.com/article/influenza-vaccination-containing-adjuvant-causes-cardiac-autonomic-dysfunction

Since we know vaccinations cause inflammation that can damage the brain imagine what is happening to an infant when an expecting mother gets vaccinated.

https://www.ncbi.nlm.nih.gov/pubmed/21945263

Brain inflammation has been linked to most mental diseases including alzheimer’s. Mugwort, coconut oil and astaxanthin have been shown to help with brain inflammation. They also stimulate brain repair.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925815/

When chronic inflammation persist it can make the brain prone to infection. Lyme has been known to form cyst in the body and can damage the brain by forming cyst on it. Lyme causes systematic inflammation it is part of it’s tactic for evading the immune system.

https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-5-40

Inflammation causes high glutamate levels which will cause restless leg syndrome and difficulty sleeping. When glutamate levels get too high it will feel like your skull is going to split in half. To restore normal glutamate levels we must address the metabolic issues causing it and reduce inflammatin.

http://www.rlcure.com/glutamate.html

If inflammation persist it can effect enzymes in the body leading to neurological damage.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986855/

Skin inflammation is usually a sign of high TH17 levels. I have posted on autoimmunity and it should cover information concerning high TH17 levels.

https://www.hindawi.com/journals/jir/2013/261037/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633446/

Lipoxins are very important for reducing inflammation so it is very important to support their function. Lipoxins cannot remove inflammation until the cause of the inflammation has been removed. If we have metabolic issues or issues in fat metabolism the body cannot produce lipoxins which will increase inflammation. Lions Mane mushroom increases lipoxin. Low lipoxin levels cause asthma and allergies. Consuming Omega 3 and medium chain fatty acids increases lipoxins.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598198/

https://www.kidney-international.org/article/S0085-2538(15)49822-9/fulltext

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598198/

https://www.wellness.com/reference/allergies/lipid-mediators

https://restorativemedicine.org/digest/lions-mane-demonstrates-unique-potential-modify-progression-alzheimers/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823369/

There are many naturals that help with inflammation but they have to be geared towards the type of inflammation and also the cause. For example Golden Rod helps with swelling in the feet and legs and high blood pressure. Golden Rod also has antispasmodic effects which also helps with bladder and muscle pain. It also has antimicrobial effects. It also helps reduce many of the inflammatory markers found in interstitial cystitis. There are a variety of species but they are mostly chemically very similar.

https://ndnr.com/autoimmuneallergy-medicine/solidago-an-inflammation-modulator/

https://www.ncbi.nlm.nih.gov/pubmed/27249953

https://ndnr.com/autoimmuneallergy-medicine/solidago-an-inflammation-modulator/

Stimulating the vagus nerve helps to reduce inflammation and pain.the health of the vagus nerve is very important it can even effect our heart and contribute to obesity and fatty liver disease.

https://www.wisegeek.com/what-is-the-vagus-nerve.htm

https://healinghistamine.com/the-vagus-nerve-inflammation-connection/

https://upliftconnect.com/toning-vagus-nerve-heals-pain/

https://www.verywellhealth.com/the-importance-of-the-vagus-nerve-1746123

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082307/

https://www.ncbi.nlm.nih.gov/pubmed/25433161

Cholesterol is needed to prevent inflammation.

https://www.sciencedaily.com/releases/2013/12/131209105240.htm

Pau D Arco is an all around amazing herb. It fights candida, inflammation, mycoplasma you name it. It even helps heal stomach ulcers.

https://draxe.com/pau-darco-tea/

Proteolytic enzymes help break down food and reduce inflammation, they help the gut heal. There are plant sources for those not producing them.

https://draxe.com/proteolytic-enzymes/

5-Lox inhibitors help with illnesses caused by high eicosanoids like asthma and allergies. Caffeic acid inhibits 5-Lox, it can be found in coffee, thyme, basil, cinnamon, star anise, red wine, black chokeberry, barley, rye and apricots. Lichen inhibits 5-lox with cetetia monachrom being the most potent. Tithonia Diversifolia and Viguiera Robust inhibit 5-Lox and Cox-1 which would help with those who have systematic inflammation.

If excess oxidative stress and inflammation and the things causing them are not addressed it leads to neurological damage. Vaccinations, glyphosate and other farm chemicals that are high in our food supply cause systematic inflammation. Heavy metal also causes systematic inflammation. I have posted on detoxing which helps reduce their effects.

https://journals.lww.com/co-neurology/Abstract/2005/06000/Role_of_inflammation_in_neurodegenerative_diseases.19.aspx

One thing found to be common in obesity is low grade inflammation.

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2265.2012.04401.x?deniedAccessCustomisedMessage=&userIsAuthenticated=false

Vaccine inserts will state that brain inflammation is a side effect of the vaccine. They no longer call it autism because vaccines cause many types of brain injury so they us a blanket term encephalopathy to cover a variety of brain injuries vaccinations cause. Tylenol also causes brain inflammation and liver damage because it depletes glutathione so it enhances the inflammatory effects of vaccines. Two things all with autism have in common are brain inflammation (encephalopathy) and autoimmunity. Both things vaccinations and glyphosate have been shown to cause.

https://www.hopkinsmedicine.org/news/media/releases/brain_inflammation_a_hallmark_of_autism_large_scale_analysis_shows

http://reset.me/story/could-a-common-painkiller-cause-brain-inflammation-and-even-autism-in-children/

https://journals.sagepub.com/doi/pdf/10.1177/0300060517693423

https://onlinelibrary.wiley.com/doi/full/10.1111/dmcn.13432

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5143489/

Many do not realize that their chronic fatigue (ASIA syndrome), lupus or allergies are actually vaccine injury because the CDC says that only 10% of vaccine injuries get reported but many medical professionals claim that number is much lower. I have posted on identifying vaccine injury because it is usually subtle or brushed of by the medical community. It is up to the parent of the injured child to report vaccine injury or the person who is injured. If you do not keep accurate medical history and medical journals your chances of being compensated for vaccine injury or death is very slim.

https://www.wellnessresources.com/news/vaccine-injury-with-chronic-fatigue-syndrome-and-fibromyalgia

N-acetylcysteine helps with damage from tylenol. High stress and high cortisol levels also have a negative impact on BHMT enzymes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798828/

https://www.snpedia.com/index.php/Rs651852

Encephalitis and autism is the same thing. They relabeled autism encephalopathy in order to cover a broader spectrum of brain injuries caused by vaccines and farm chemicals.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717322/

Many vaccines contain aluminum which is known to be toxic to the body and it is very difficult for the body to remove it especially once it enters the brain. It has been linked to autism.

https://www.sciencedirect.com/science/article/pii/S0946672X17308763

https://www.nature.com/articles/srep31578

https://www.sciencedirect.com/science/article/pii/S0946672X17308763

https://www.psychologytoday.com/us/blog/brain-and-behavior/201708/brain-inflammation-in-patients-ocd

If the brain inflammation persist long enough it can result in mental disorders.

https://igennus.com/practitioner-blog/inflammation-target-treating-mood-disorders-depression/

https://chriskresser.com/is-depression-a-disease-or-a-symptom-of-inflammation/

When mast cells degranulate they release histamines. Excess histamines cause inflammation. If the immune system is not balanced it could lead into mastocytosis or mast cell activation syndrome. High mast cell levels cause allergies, inflammation, asthma and man other illnesses. We need mast cells to clean up the body but over expression can cause illness.

https://healinghistamine.com/autism-spectrum-disorders-linked-to-mast-cell-activation/

https://www.nature.com/articles/tp201677

https://www.sciencedirect.com/science/article/pii/S0925443910002954

https://www.nature.com/articles/tp201677

http://www.bloodjournal.org/content/112/4/946?sso-checked=true#sec-12

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Mast cells are needed for health but excess and excess degranulation can damage nerves.

https://aacijournal.biomedcentral.com/articles/10.1186/1710-1492-1-2-65

Histamines compromise the blood brain barrier causing the brain to become even more inflamed. It also leaves the brain open to toxins and infection.

https://link.springer.com/article/10.1023%2FA%3A1007074420772?LI=true

Some may be helped with a low histamine diet. I have posted on autoimmunity and some tips for some things that will help.

https://wakeup-world.com/2017/01/17/suffering-from-migraines-anxiety-depression-or-fatigue-you-may-be-histamine-intolerant/

This is why high homocysteine levels lead to inflammatory diseases , it has also been linked to IBD. Often times it is nutrient deficiencies that causes high homocysteine levels. Eating more raw fruit, vegetables and leafy greens can help reduce high homocysteine levels. Also if a person is deficient in B12 which is produced by our gut microbiome and B6 they will develop high homocysteine levels. High homocysteine levels can lead to cardiovascular disease, insulin resistance, excess oxidative stress., issues with glutamate because it acts on the NMDA receptor, it can cause the blood brain barrier to become leaky, and can lead to depression. It can cause hoshimoto’s disease, arthritis, psoriasis, lupus which all indicate high TH17 levels. High homocysteine causes headaches, inflammation in the gums and mouth. Www.selfhacked.com is one of the most accurate websites I have found when it comes to healing and health related information.

https://www.nature.com/articles/ajg2005155

https://www.drweil.com/health-wellness/body-mind-spirit/heart/elevated-homocysteine/

https://www.selfhacked.com/blog/optimal-homocysteine-levels-increase-decrease/

http://www.themethylationdoctor.com/blog/page/2/

I am not big on drugs because the pharmaceutical industry and even our own government has shown they can not be trusted when it comes to drug safety. They have often times caused many death from marketing drugs that they falsely claimed to research for safety and the government has many times been caught colluding with them to hide the harm being done. But Ebselem is one drug I have seen many independent studies showing it’s effectiveness at reducing oxidative stress, inflammatory disease and reversing autoimmunity. Unfortunately most governments only allow it to be prescribed to those who are mentally ill.

https://www.sciencedirect.com/science/article/pii/S0014579396012379

Vaccinations, heavy metals, stress, toxins, farm chemicals in our food, gut dysbiosis, glyphosate and glufonisate increases zonulin levels which causes leaky gut. This results in autoimmunity, allergies and food intolerances which leads to systematic inflammation. There are test that can help identify leaky gut. It is not always obvious when someone has leaky gut. High zonulin levels also cause interstitial cystitis and a leaky blood brain barrier.

https://doctordoni.com/2011/11/what-is-leaky-gut/

https://www.ncbi.nlm.nih.gov/pubmed/21248165

https://www.selfhacked.com/blog/glucocorticoid-receptor/

https://www.jillcarnahan.com/2013/07/14/zonulin-leaky-gut/

high zonulin levels have been linked to leaky gut.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363162/

Almost all chronic illness can be linked to our gut microbiome.

https://www.frontiersin.org/articles/10.3389/fmicb.2018.00432/full

Many with inflammatory bowel diseases and chronic illness have been shown to be deficient in Clostridium Leptum. Has been shown to help with asthma and allergies.

https://www.annallergy.org/article/S1081-1206(12)00467-X/abstract

Vitamin B6 helps reduces brain inflammation. Some who are not converting B6 may have to use the bioavailable form P5P.

http://www.hormonesmatter.com/reducing-brain-inflammation-vitamin-b6/

Disruption of lysosomes can lead to inflammatory disease. I have posted on things that may help with lysosomal issues.

https://journals.sagepub.com/doi/abs/10.1177/2326409816650465

Poshpolipase A2 activates during infection. Citroline helps reduce inflammation caused by PLA2. It should not be used often because the body recycles it and if we get too much it can start damaging the liver.

https://www.greatplainslaboratory.com/gpl-blog-source/2017/10/16/the-connection-between-chronic-inflammation-and-disease

Our Liver X Receptor is important for homeostasis of the immunes system and in preventing inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2641014/

Yarrow reduces inflammation in the digestive tract. It also give energy without the side effects of caffeine. It also helps with asthma.

https://draxe.com/yarrow/

There are many toxins in our food and enviroment that cause inflammation. If we do not detox them and leave the inflammation continue then it can lead to autoimmunity and cancer. Oxidative stress causes inflammation so the source of the oxidative stress needs address, treating the inflammation would only be treating the symptoms. Cancer is a symptom of illness but not the cause, it is a symptom of an underlying illness. I have also posted on cancer in more detail.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300235/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492068/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990475/

https://www.ncbi.nlm.nih.gov/pubmed/24474192

Tea tree oil works great for reducing histamines, and substance P in the skin. It reduces inflammation and has great disinfectant properties. It is too strong to use straight. I found adding about 5 drops to 8 ounces of Jojoba oil worked great. Jojoba oil stimulates hair growth and reduces inflammation. It also will disinfect , it even kills fungus.

https://www.ncbi.nlm.nih.gov/pubmed/12452873

Infection causes inflammation, if systematic inflammation is not addressed it can lead to interstitial cystitis. It is very difficult to recover from. I am in remission with no help from allopathic medicine they just made things worse. They will try and prescribe you psych meds and tell you it is in your head like they do with Lyme disease. There are two things I have seen common in the many types of interstitial cystitis. Leaky gut or digestive issues and high inflammatory cytokines. High substance P levels have been found in some types of asthma , autoimmunity and all with interstitial cystitis have high substance P levels. I have posted on substance P. It is a sign of leaky gut or gut dysbiosis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126088/

https://www.ncbi.nlm.nih.gov/pubmed/22310775

Often times with IC it is hormone imbalance that causes the inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189612/

Infection causes issues with tryptophan this can lead to both malabsorption and interstitial cystitis. I have seen people go years with undetected infections because it was tick born illness and they always over look it. As a matter of fact some studies claim up to 80% of those with interstitial cystitis may have tick born illness that is going undetected. Tick born illness is not what it should be called though because most illnesses ticks transmit can be transmitted by biting insects including Lyme disease. When this happens a person may become sicker when increasing tryptophan levels in their bodies. They must address the cause first. I have posted on healing interstitial cystitis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415894/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3165469/

Our adrenaline levels can effect our bodies causing inflammation and autoimmunity. Adaptogens like suma root or maca root usually help with that.

http://www.eurekaselect.com/103584/article

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620417/

If you do not have porphyria then Omega 3 fatty acids will reduce inflammation in the bladder. If you have porphyria, which pyrrole issues are some of the first symptoms then all oils except medium chain fatty acids will cause you inflammation. Also if your Omega 6 levels get higher then Omega 3 then instead of reducing inflammation Omega 6 will cause inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/26411429

Transfats cause inflammation and can lead to cardiovascular disease. I have posted on the myths about fat.

https://www.ncbi.nlm.nih.gov/pubmed/15735094

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082111/

There are a lot of farm chemicals in our food. PON1 is needed to detox them. Inflammation inhibits PON1. Reducing inflammation will help with detoxing. Sumac helps to stimulate PON1. Dandelion stimulates DIG1 which detoxes the body. Alternating between them should help to detox.

https://www.selfhacked.com/blog/about-pon1-and-natural-ways-to-increase-it/

Fats which are needed by almost all cells of the body can make inflammation worse if a person has pyrrole issues. If a person has pyrrole issues it is a symptom of a bigger problem porphyria. They will get ill from consuming oils. Medium chain fatty acids is all they should consume until they have addressed it. I have posted on porphyria.

https://www.samanthagilbert.com/pyroluria-pyrrole-disorder/

It is very important to address issues with fat metabolism. Omega 3s are needed to reduce inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/12480795

Milk thistle is one of the best for reducing inflammation and detoxing. It inhibits many inflammatory pathways.

https://www.ncbi.nlm.nih.gov/pubmed/26186142

Thiocyanate is used by the bodies antioxidant system. A deficiency causes cause cystic fibrosis. Excess can cause hypothyroidism so should be avoided by those who have hypothyroidism. It also helps with sickle cell anemia.

It is found in cassava, legumes, beans, grains, many root vegetables.

http://journeytohealthsca.blogspot.com/2013/02/thiocyanate-rich-foods-to-eat-daily-or.html

https://www.nairaland.com/2126358/thiocyanate-all-natural-cure-sickle

http://journeytohealthsca.blogspot.com/2013/02/thiocyanate-rich-foods-to-eat-daily-or.html

https://www.ncbi.nlm.nih.gov/pubmed/19918082

St. Johnswort reduces inflammation and oxidative stress. It has a cannabinoid in it that that causes relaxation. The best way I know how to describe it is that it gives you that feeling you get when you are fighting sleep as a child and you get giggly.

https://www.ncbi.nlm.nih.gov/pubmed/25851311

Chlorophyll helped me a lot. It is high in copper so should only be used a few times a week , I used it about three times a week. It is also a good source of magnesium and increases oxygen levels in the blood.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806384/

If a person gets mast cell activation syndrome from Lyme there are a number of things people have tried. Supplements worked best for me. I have covered this in my autoimmunity post. When mast cells degranulate they cause high histamines which cause inflammation. It is very important to get them under control and restore homeostasis. We need some histamines to fight infection and for digestion so we do not want to over do it.

http://goodbyelyme.com/stopping_mast_cell_inflammation

https://alisonvickery.com.au/anti-histamine-foods/

When I was very ill my skin started to lose it’s color . When it is low the immune system will become imbalanced and we will develop inflammation throughout the body. On the other end of the scale those who have chronic fatigue syndrome have excess a-MSH. If levels are high a person will not have an appetite.

https://www.selfhacked.com/blog/alpha-msh-its-role-in-weight-control-autoimmunity-cirs-and-cfs/

https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-10-73

Nitric Oxide can be beneficial or cause inflammation. Under excess oxidative stress it can become depleted causing high blood pressure or over produced during infection causing low blood pressure. I have posted on nitrositive stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906415/

Butyric Acid is great for reducing inflammation throughout the body including the brain. It also helps protect and heal the brain. It is found in butter and ghee, also some of our gut microbiome produce it. If we lose our gut microbiota that produce butyric acid we can develop inflammatory bowel or ulcerative colitis.

https://wholehealthsource.blogspot.com/2009/12/butyric-acid-ancient-controller-of.html?spref=fb

https://gut.bmj.com/content/63/8/1275.long

Also our gut microbiota communicate with our brain , a deficiency in certain microbiota could lead to mental illness.

https://www.mdpi.com/1424-8247/11/3/63

If we have leaky gut or tick born illness we can develop high substance P levels. This can cause cell build up in various areas of the body and can block the renal system , blood flow, it can cause brain swelling. When levels get high the skin will burn especially in the scalp and down the spin. The burning with increase at night and can also itch. Substance P levels increase at night. Substance P is used by the body to stimulate healing in the body. Excess substance P can cause excess bone marrow to be produced. I have posted on how to reduce it. When it gets very high brown spots may develop around the hair follicles. Nutrient deficiencies can also cause high substance P levels especially magnesium. This is also why many have leaky gut now days because high substance P levels cause leaky gut. Over farming and the use of glyphosate has caused many to become deficient in magnesium. If high substance P levels are not addressed it can lead to pancreatic damage and even cancer. If substance P levels get high enough it can feel like bugs crawling under and on the skin, I experienced that. I also experienced butt itching which drove me almost to the point of madness.

http://www.drwardbond.com/dr-bs-blog/trichodynia-pain-and-substance-p

https://bjsm.bmj.com/content/48/19/1414

https://www.wellnessresources.com/news/magnesium-is-essential-for-preventing-substance-p-overload

https://www.wellnessresources.com/studies/magnesium-adequacy-prevents-excess-substance-p

http://mcr.aacrjournals.org/content/11/3/294

http://www.hh.um.es/Abstracts/Vol_29/29_7/29_7_881.htm

Self heal helps reduce inflammation, helps balance the immune system and fights viruses. It also reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269750/

https://www.sciencedirect.com/science/article/pii/S0887233308003159?via%3Dihub

Since cardiovascular disease is from inflammation and oxidative stress self heal heps protect the heart by reducing inflammation and oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133916/

Phloretin found in apple leaves is great for reducing inflammation and balancing the immune system.

https://www.mdpi.com/2072-6643/10/7/868

Grape seed extract is great for inflammation it reduces many types of inflammatory cytokines including bradykins. It reduces TMAO which causes inflammation. It also helps normalize our gut microbiome. It prevents thrombosis and protects the heart. It helps heal neurological damage. Those who have hepatitis may not be able to use it. It contains resveratrol which can activate hepatitis. It contains resveratrol which reduces the inflammatory cytokines that cause neurological damage and leaky gut.

https://www.ncbi.nlm.nih.gov/pubmed/25920255

https://www.ncbi.nlm.nih.gov/pubmed/30107238

Resveratrol helps with obesity by reducing the inflammation that causes it. It is also an Nrf2 activator so reduces oxidative stress. Keep in mind we do not want to reduce oxidative stress too low because we need it to produce enzymes, protect us from infection and toxins and cancer. Homeostasis should always be the goal. To little inflammation or oxidative stress can cause cancer, to much can also cause cancer we need to balance things out.

https://www.hindawi.com/journals/omcl/2013/793525/

https://www.sciencedirect.com/science/article/pii/S0006291X10021108

Serrapeptase is an enzyme that silk worms use to escape their cocoon. It has great anti-inflammatory properties. It breaks down scar tissue in the body and can break down cyst formed by infection. It should only be used in low doses. High doses can also start breaking down tissue in the body good tissue in the body , do not take in high doses. It also breaks down biofilms.

https://www.ncbi.nlm.nih.gov/pubmed/2257960

I have never tried chrysanthemum but it is supposed to reduce inflammation and protect from renal injury.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504943/

Red gensing has a lot of health benefits but those with high blood pressure should not use it. It is a stimulant.

https://onlinelibrary.wiley.com/doi/abs/10.1111/jphp.12529

Pau D Arco contains B-lapchone which has been found to fight many types of cancer. It has been found to protect the renal system and reduces inflammation and oxidative stress. Fights many pathogens including mycoplasma. It improves NAD+/NADH ratio which is usually a problem in inflammatory bowel diseases.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942788/

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047122

Uncaria tomentosa is cat’s claw. There are other herbs called cat’s claw but this is the only one that has well researched health benefits. It helps reduce inflammation, strengthens the immune system and has been shown to help with asthma.

https://www.ncbi.nlm.nih.gov/pubmed/29432856

Hesperidin is great for healing, reducing inflammation and reducing histamines. It is also a helicase inhibitor so helps fight viruses. It is found mostly in the white parts of citrus fruits and peppermint.

http://www.nrcresearchpress.com/doi/abs/10.1139/cjpp-2014-0204#.XB5FZXKYUua

https://www.selfhacked.com/blog/hesperidin/

Palmitoylethanolamide helps with many types of chronic illness. It helps keep the cannabinoid system healthy. It is involved with cellular repair, nerve repair and reduces inflammation. It prevents cardiovascular disease and protects from inflammatory bowel diseases. It helps with mast cell activation syndrome. It is found in eggs and peanuts.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878779/

https://www.selfhacked.com/blog/palmitoylethanolamide-pea/

https://www.sophiahi.com/pea-neuro-inflammation/

https://www.hindawi.com/journals/iji/2013/151028/

https://www.healthrising.org/blog/2014/09/19/palmitoylethanolamide-pea-medical-food-fibromyalgia-chronic-fatigue-syndrome-mecfs/

https://www.linkedin.com/pulse/palmitoylethanolamide-bodys-natural-anti-inflammatory-frank-md/

https://www.healthrising.org/blog/2014/09/19/palmitoylethanolamide-pea-medical-food-fibromyalgia-chronic-fatigue-syndrome-mecfs/

Those with high dopamine or serotonin levels may want to avoid taking PEA it increases them.

https://naturodoc.com/pea_science/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744360/

Melatonin is an amazing antioxidant with many amazing benefits. Usually I don’t like taking something the body can make itself because it can ruin the bodies ability to produce it but melatonin does not do that. It is great for chronic illness, sleep problems and autoimmunity. It reduces inflammation and oxidative stress.

https://onlinelibrary.wiley.com/doi/abs/10.1111/jpi.12192

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582546/

http://www.fupress.net/index.php/ijae/article/view/21483

This is one of those things I thought was crazy is earth grounding. So I look for research to show people who believe that had to be crazy. Turns out earth grounding resets the bodies voltage back to what it should be. Toxins and EMFs change our bodies voltage which causes inflammation. Earth grounding reduces inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378297/

Nobiletin restores cellular autophagy which is the cells way of cleaning itself out and repairing. It is also how the cells protect themselves form infection. It reduces inflammation , helps with fatty liver and diabetes. It should be used in moderation it is a very potent nutrient. It is found in the skins of orange peels. Other citrus fruits have similar phytochemicals that have very similar effects. It even helps with acne. It even helps with learning impairments. Autophagy is also a very important part of the immune system and helps protect the cells from infection.

https://www.ncbi.nlm.nih.gov/pubmed/28116779

https://www.sciencedirect.com/science/article/pii/S1658077X16300960

http://www.phytochemicals.info/phytochemicals/nobiletin.php

http://www.phytochemicals.info/phytochemicals/nobiletin.php

http://microbialcell.com/researcharticles/peering-into-the-black-box-of-pathogen-recognition-by-cellular-autophagy-systems/

Polysaccharides in musthrooms are great for balancing our gut microbiome and reducing inflammation. They also improve immune function.

https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-9-54

Marshmallow root has amazing healing properties it is great for balancing the immune system, reducing inflammation, amazing for healing the gut. Most plants in the mallow family contain those properties.

https://www.omicsonline.org/open-access/the-effect-of-malva-neglecta-on-the-reduction-of-inflammatory-agents-in-patients-with-osteoarthritis-2168-9547-1000135.php?aid=61436

Bay leaves have amazing benefits and I craved them when I was ill , they seemed to help with my nausea. My dad always told me not to use it too often. I have not had a chance to look at toxicity studies on it.

https://www.organicfacts.net/health-benefits/herbs-and-spices/bay-leaves.html

Japanese honeysuckle reduces inflammation and histamines. It also stimulates repair of the heart and reduces thrombosis. Honey suckle also fights many types of infection from mycoplasma to viral.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014484/

https://www.ncbi.nlm.nih.gov/pubmed/27534446

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492671/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765429/

Plantain herb is another herb with amazing healing properties. It contains baicalein which is what makes scutellaria mare effective. It kills many types of infection including gangrene. It reduces Cox-1 and Lox which would help with allergies and interstitial cystitis. It also helps with renal damage.

https://www.sciencedirect.com/science/article/abs/pii/S0731708510001007?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537734/

https://www.mdpi.com/1420-3049/20/10/17747

Mugwort is another amazing plant. It helps heal the renal system and brain , fights many pathogens including mycoplasma. It reduces inflammation and is 1000 as potent against cancer then chemotherapy. Mugwort increases the bodies antioxidants and prevents heart disease.

https://draxe.com/mugwort/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4512891/

Scutellaria is high in baicalein which prevents thrombosis, reduces inflammation and balances the immune system. There are two types usually sold on the market american and chinese. Amercan is higher in baicalein. I used american when I was sickest and because it is so potent the sudden restored blood flow to my legs, hands, and brain caused a lot of problems. I experienced headaches from the barin starting to heal, I experienced muscle spasms in my legs and feet and burning pain from the nerves and muscles waking up. I experienced burning in my hands. I wold suggest using chinese which would not cause such sudden healing.

https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-015-0219-6

Frankinsense is another super herb. It is from the sap of 5 different spcies of Boswellia. Their sap has been found to help with asthma, inflammation, very good at fighting infection, heals leaky gut and helps with gut dysbiosis. Has been found to help with peristalisis (when the gut is paralyzed. Has been found to fight cancer. The essential oil has been shown to fight skin cancer and reduce scars on the skin. It has been shown to prevent oral infections. The list of benefits goes on and on.

https://www.organicfacts.net/health-benefits/essential-oils/health-benefits-of-frankincense-essential-oil.html

If leaky gut is not corrected it can lead to liver and kidney disease. Leaky gut is not always obvious it usually presents as food intolerances and the number of food intolerances will increase the worse it gets.

https://academic.oup.com/ndt/advance-article-abstract/doi/10.1093/ndt/gfy172/5043141#.W1TXZnvKNpQ.facebook

Cox-2 inhibitors are good for healing the gut and bladder. Cox-2 inhibitors help with some types of asthma and interstitial cystitis. Things that inhbit iNOS would help with interstitial cystitis. They act similar to NSAIDs without the side effects. Remember you do not want to inhibit COX-2 For too long because we need it for healing, once homeostasis is reach it would be a good idea to just take some once in a while. Natural salicitic acid found in willow bark works as well as NSAIDs if a person has sulfation issues it can make them ill, it can also irritate the stomach if over consumed. Myrtus Communis also reduces pain as well as NSAIDs but I have not found any toxicity studies on it. Myrtus communis does work very well for healing the gut. https://www.ncbi.nlm.nih.gov/pubmed/29303617 . But does not inhibit Cox-2. Cox-2 inhibitors also help heal the gallbladder.

Lysolecithin causes bladder inflammation. Lysolecithin causes systematic inflammation interstitial cystitis, neurological damage and has been implicated as a causative factor in MS. It is needed for autophagy and low levels can cause hardening of the arteries. Lysolecithin is in high amounts in processed foods and enzyme-modified foods. It is also known as Lysophosphatidylcholine. It is also released from cells during inflammation. It can cause bile blockage. The problem is all processed foods are very high in it which raises our bodies levels too high. lysoPC in high amounts damages the mucus membrane of the gut, combined with alcohol it is much worse. Cigarette smoking also causes damage by rasing LP-PLA2 which increases oxidative stress and lysoPC. I cannot find the link to the study but it causes interstitial cystitis through the nerve damage it causes.

https://www.plefa.com/article/S0952-3278(99)90011-X/pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365627/

Mediterranean Sage reduces COX-2, and iNOS. It also reduces oxidation of lipids.

https://link.springer.com/article/10.1007/s000110050730

Lysolecithin

https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.306964

https://www.cell.com/cell/fulltext/S0092-8674(03)00422-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867403004227%3Fshowall%3Dtrue

https://link.springer.com/article/10.1007%2FBF01891668

http://www.jneurosci.org/content/jneuro/18/7/2498.full.pdf

https://link.springer.com/article/10.1007%2FBF01296164

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866188/

Alterations in our gut microbiome can contribute to muscular dystrophy.

https://www.nature.com/articles/ncomms12015

Curcimin inhibits COX-2 but if used for too long it can make you anemic so should be pulsed and not used daily. Thunder God Vine reduces COX-2 without inhibiting it’s effects but it can have effects on our hormones if taken for too long. Resveratrol and Querciten inhibit COX-2 with many beneficial effects. Green Tea inhibits COX-2 but over consumption can damage the liver. All things should be done in moderation and homeostasis should be the goal.

http://www.chiro.org/nutrition/FULL/Natural_COX-2_Inhibitors.shtml

Bulgleweed in the mint family inhibits COX-2,

Many of the cornus (dogwood) species the berries reduce inflammatory cytokines and inbibits COX-2,

Groundcone reduces TNF-a, iNOS and COX-2,

Catalpa helps with colitis, inhibits many inflammatory cytokines and COX-2.

Cape Jasmine heals the retina by improving oxygen levels in tissues. It inhibits iNOS and Cox-2. Yellow gentian produces one of the most bitter substances known. Bitter substances stimulate bile. It helps normalize the NMDA receptor which can be overstimulated by metabolic issues causing head aches and anxiety.

Cox-2 is a precursor to prostaglandin E2, mock privet leaves inhibit PGE2.

Rehmannia root should not be taken if the immune system is over activated for example with mast cell activation because it stimulates the immune system. Rehmannia leaves inhibit blood clotting. Rehmannia helps prevent depression and helps with blood brain barrier repair by improving production of tight junction proteins which would also help heal the gut.

Foutainbush also known as firecracker plant reduces inflammation and oxidative stress, it fight infections like malaria. It depresses the central nervous system which improves sleep.

Water figwort inhibits inflammatory cytokines, especially the ones that cause skin inflammation. Desert figwort has similar properties but has a little more potent inflammatory inhibiting effects. Ironwort also known as mountain tea inhibits inflammation, reduces oxidative stress and helps heal the gut. It inhibits Lipoxygenase.

Blue snakeweed reduces anxiety through the GABA and opioid receptors and enhances sleep. It also reduces pain. It fight malaria. It also has potent anti-inflammatory effects and helps heal the gut.

Lilac flowers and bark reduces hydrogen peroxide levels in the body, it reduces lipid peroxidation, and reduces Nitric Oxide levels in those with excess Nitric oxide. In other words it reduces oxidative stress. It also reduces TNF-a , NFK-B and IL-6 and other inflammatory cytokines. It also helps with diabetes. It also stimulates IL-10 which is usually inhibited by the OspA protein in vaccines and some infections like Lyme. It also contains rutin which fights infection.

Water speedwell is in the plantain family. It reduces oxidative stress and reduces inflammatory cytokines stimulated by endotoxins.

Vitex inhibits Cox-2

Liverwort is very effective against fungus even nail and skin fungus. It is anti-inflammatory but contains a cannabinoid that is very potent so should be used in moderation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873812/

Nutmeg inhibts COX-2 and has a cannabinoid that has narcotic like effects. It should not be used in high doses. In high doses it can cause seizures and even death. It has hepaprotective, antiseptic, memory enhancing and reduces inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848392/

https://www.researchgate.net/publication/260386780_Biological_Effects_of_Myristica_fragrans

Chicory prevents biofilms, helps normalize gut microbiota, it is a bitter herb so stimulates bile production, it fights many infections including malaria and helps fight parasites. It reduces inflammation and is hepaprotective. Helps heal the gut. It has mild sedative effects and reduces pain. It reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860133/

Speedwell reduces inflammation by inhibiting Cox-2 and TNF-a. Has strong antioxidant and antimicrobial properties. It also helps with mast cell issues.

https://www.ncbi.nlm.nih.gov/pubmed/26404257

https://www.ncbi.nlm.nih.gov/pubmed/23142555

https://www.sciencedirect.com/science/article/pii/S0378874112007362?via%3Dihub

Feverfew is great for reducing pain and inflammation. It also helps fight the flu and colds. But if taken for too long a person can become addicted. When they stop taking it they will have toxic withdrawal syndrome and will feel ill and will get a very severe headache.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290145/

Berberine protects the brain, renal system, helps balance the immune system. Kills just about all types of infection including mycoplasma. Berberine improves insulin sensitivity, and prevents cardiovascular disease. It also improves lipid metabolism which would help those with pyrrole issues, it also reduces inflammation and oxidative stress. It is found in berberis, oregongrape, amur cork, and california poppy. California poppy also has pain killing properties.

http://www.jimmunol.org/content/185/3/1855

https://www.naturalmedicinejournal.com/journal/2012-12/clinical-applications-berberine

https://www.healthline.com/nutrition/berberine-powerful-supplement#section7

https://www.naturalmedicinejournal.com/journal/2012-12/clinical-applications-berberine

This is a more detail description of what causes pyrrole issues. Pretty much all heck breaks loose.

https://www.selfhacked.com/blog/everything-know-high-mauve/

This one surprised me. I have only seen studies on the bark and roots of paeonia flowers but the health benefits have been amazing, helps with diabetes, heart disease and even helps balance the immune system. It reduces inflammation, oxidative stress and helps normalize the adrenal hormones. It even inhibits cancer growth. It even reduces brain inflammation. It reduces oxalates which are very damaging to the body. It improves gut motility which would help those who have digestive disorders that causes constipation. It also helps prevent biliary blockage which would cause inhibited bile production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108611/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844255/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858241/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740769/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292961/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014290/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4968804/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802119/

If inflammation is not addressed it can lead to bone loss.

https://joe.bioscientifica.com/view/journals/joe/201/3/309.xml?fbclid=IwAR1moide9HczXIb6QL0xfbtDZOR4lYVmW0g7Nlddheelvms21JyxhpJPjKY

Magnolia has a cannabinoid that reduces pain and inflammation, it also helps with inflammatory bowel issues. It stimulates bone growth, and reduces depression by it’s actions on the GABA receptor it also prevents glutamate build up by increasing the hormone that converts glutamate to GABA, It reduces inflammation by inhibition of PPARy and many of the cytokines found in inflammatory bowel diseases. It has been show to be effective against many metabolic disorders. It inhibits blood clotting it is very effective against cancer, it has been know to fight forms of cancer that are drug resistant. Magnolia reduces oxidative stress and helps restore proper lipid function in the body. It has been shown to fight fungus, Hepatitis C and HIV. It helps with hypertension and is and ACE inhibitor. Most species of magnolia are chemically similar.

https://www.ncbi.nlm.nih.gov/pubmed/30573364

https://www.ncbi.nlm.nih.gov/pubmed/30214227

https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-135

https://www.ncbi.nlm.nih.gov/pubmed/27721050

https://www.ncbi.nlm.nih.gov/pubmed/30466619

https://www.researchgate.net/publication/319186047_The_antiviral_activity_of_Egyptian_Magnolia_grandiflora_on_Human_Immunodeficiency_Virus_HIV

https://www.ncbi.nlm.nih.gov/pubmed/22098176

Flax seed has a cannabinoid similar to thc. It has anti-inflammatory effects, reduces histamines, reduces pain, helps heal the gut. It is high in Omega 3 fatty acids. Flax seed must be crushed because humans cannot digest that has not been crushed. Flax seed is also high in mucilage so helps heal the gut. It balances our gut microbiome. It reduces oxidative stress. It has been found to heal the kidneys and reduce the risk for cardiovascular disease. It helps with diabetes and normalizes blood sugar levels.It has been shown to restore leptin sensitivity which would prevent obesity. It improves glucose tolerance and gut motility. Flax seed is high in arginine which reduces blood pressure.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275574/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152533/

https://www.sciencedirect.com/science/article/pii/S0924224414000697

Leptin levels increase during infection and is known to be high in those suffering from sepsis. Leptin contributes to the production of inflammatory cytokines and oicosanoids. So if a person has inflammation, allergies, mast cell issues or asthma they may want to avoid leptin until they have those issues corrected.

https://www.ncbi.nlm.nih.gov/pubmed/12629120

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453851/

The type of asthma described in this link is caused by leaky gut. The symptoms they describe are symptoms of leaky gut. The worse a person gut becomes the more allergies they will develop. This can be caused by vaccine injury, farm chemicals in food or toxins like mercury still found in some vaccines. It is necessary to detox and balance the immune system to help with this type of asthma.

https://www.atsjournals.org/doi/full/10.1164/ajrccm.164.supplement_1.2103024

Our western diet with the processed foods have been shown to cause inflammatory and autoimmune diseases.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034518/

I included information in this post about things that help with asthma but what isn’t covered here I have covered in this post. https://iamajuicer.wordpress.com/2018/07/20/things-that-may-help-with-copd/

There are metabolic issues that can cause leptin deficiencies. This study describes some things that may help.

https://link.springer.com/article/10.1007/s40618-018-0887-z

Black Sativa seed is another super food. It reduces inflammation and heals the gut. It reduces oxidative stress and is hepaprotective. It helps with proteinuria which is a symptom of porphyria. It has been shown to promote the growth of B cells in the pancreas and helps fight cancer. It helps ease the symptoms of asthma. It helps with neurological damage and drug addiction. It has potent antimicrobial properties. It reduces symptoms of Hoshimoto’s . It helps reduce the symptoms of asthma and mast cell activation syndrome. It reduces histamines. It decreases viral load in those with hepatitis C. It improves memory and breast milk production. It increases IL-10 , which is inhibited by the OspA and disables the immune system. Many things like vaccines, mycoplasma and Lyme contain the OspA which inhibits IL-10. Inhibiting IL-10 disables the immune system. Increasing IL-10 restore proper immune function.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883276/

https://www.verywellhealth.com/nigella-sativa-89064

http://www.journal.ac/sub/view/223

https://www.ncbi.nlm.nih.gov/pubmed/29154069

https://www.ncbi.nlm.nih.gov/pubmed/27247928

https://www.ncbi.nlm.nih.gov/pubmed/29587770

https://www.ncbi.nlm.nih.gov/pubmed/30340634

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646144/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387228/

Rutin is a very potent at reducing inflammation and oxidative stress. It helps with diabetes and neurological damage. Fights many types of cancer. It has sedative effects and reduces convulsions. It improves cognitive function. Helps restore pancreatic health. It helps those with high T4 levels by reducing T4 thyroid hormone levels. It prevents excess blood clotting and heals the gut. It reduces histamines and eisonophils which helps with asthma and allergies. It heals the gut and improves gut motility. It stimulates bone growth. It has antimicrobial properties and fights mycoplasma and viral infections. It is a COX-2 inhibitor and has been found to protect from sun damage. It normalizes the immune system and reduces most inflammatory cytokines. It reduces fatigue and is neuroprotective.

Rutin is found in the waxy part of the skins of red apples, white skin of citrus fruit, buckwheat, figs,cherries, apricots, rooibos, and black and green tea are high in rutin. Be careful drinking too much black and green tea. Drinking them excessively can damage the liver. Anything can harm our health if used in excess.

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1069-1

https://www.ncbi.nlm.nih.gov/pubmed/29017142

https://www.ncbi.nlm.nih.gov/pubmed/25929832

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355559/

Not eating enough foods effects our gut and is why so many in the western world have gut issues, that along with the BT Toxins in GMOs and glyphosate and other farm chemicals. Search my blog on GMOs and glyphosate and you will see there is a lot of research showing how they destroy the gut and brain. Processed foods are very bad on the digestive system. Once our gut is compromised it starts effecting the health of the whole body resulting in increased mast cell degranulation and inflammation. Digestive enzymes helped me a lot. I chose plant derived enzymes. They reduce inflammation, reduce mast cell degranulation which reduces histamines. They help the food break down and be absorbed by the digestive system. I tried to match the enzymes with the types of foods they broke down so what I was going to eat determined what enzymes I would use. If we are deficient in digestive enzymes we will develop gut dysbiosis, bloating, intestinal inflammation, malabsorption, all things that lead to chronic illness. Farm chemicals which are high in our food supply and processed foods inhibit our digestive enzymes. We also will develop fatigue because it inhibits the bodies ability to produce cellular energy. They help prevent cystic fibrosis and asthma. If inflammation or infection persist it can develop into brochhiectasis which causes excess mucus in the lungs. Brochiectasis can result from inflammatory bowel disease, autoimmune disease, and allergies also. All things that can be corrected. https://patient.info/health/bronchiectasis-leaflet herbs that help fight infection help with bronchiectasis. Also reduce inflammation and histamines. All things I have covered on my blog. I have covered COPD and asthma in more detail so I will not cover it much here. It is caused by either autoimmune or inflammation.

https://articles.mercola.com/sites/articles/archive/2011/08/21/enzymes-special-report.aspx

https://drjockers.com/10-benefits-digestive-enzymes/

https://draxe.com/proteolytic-enzymes/

https://www.amymyersmd.com/2016/04/digestive-enzymes/

https://amazingwellnessmag.com/conditions-wellness/how-to-use-digestive-enzymes

High levels of H2S producing bacteria in the gut can deplete thioredoxin which results in thiol build up in the body making us sensitive to thiols and causing hormone imbalances. Thioredoxin reduces hydrogen peroxide and reactive oxygen species. Hydrogen sulfide usually reduces oxidative stress and hydrogen peroxide. N-acetylcysteine usually helps when there is excess H2S production. If a person has to many sulfur digesting bacteria when they eat high sulfur foods it will cause an increase in H2S leading to intestinal inflammation. H2S prevents thrombosis and high blood pressure. H2S has been found to be decreased in age related brain degenerative illnesses. Excess H2S production in the intestines can lead to pouchitis because it inhibits gut motility. High levels of H2S causes chronic fatigue syndrome. High levels of H2S inhibit the electron transport chain which is one of the final steps in energy metabolism in the body. Excess H2S can enhance the activity of the NMDA receptor , excessive NMDA receptor activity is common in autism. When there is excess H2S thiyl radicals are produced which effect lipid metabolism.

https://www.sciencedirect.com/science/article/pii/S2213231712000080

https://www.frontiersin.org/articles/10.3389/fmicb.2018.02385/full

https://www.hindawi.com/journals/omcl/2016/6043038/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029659/

https://www.nature.com/articles/s41467-018-06373-0

http://www.mdpi.com/2076-2607/3/4/866/pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910667/

https://link.springer.com/article/10.1007%2Fs00018-005-4475-y

For some cannibus has many health benefits and has shown amazing results on cancer. Unfortunately I am one of the few that is negatively impacted by the cannabinoids in it. Fortunately there are many types of cannabinoids found in many plants. I posted on them in more detail.

https://www.cannabisreports.com/news/2015/03/09/cannabis-study-full-spectrum-cannabis-extracts-more-medically-effective-than-cbd-alone/

Rooibos tea is another amazing herb for healing. It reduces inflammation, reduces histamines, helps with asthma, it fights infection in the lungs.

https://www.worldscientific.com/doi/abs/10.1142/S0192415X15500573?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&

Choline deficiency or issues with choline metabolism can cause fatty liver, brain dysfunction, neurological damage, inflammation and oxidative stress. I had to deal with choline metabolism issues. You will get indigestion when you consume fats if you have issues with choline metabolism. That could also be a sigh of porphyria. It also causes problems metabolizing fats if you are choline deficient.

https://lpi.oregonstate.edu/mic/other-nutrients/choline

I had a lot of friends who used black ginger and they said it really helped them with a variety of illnesses from autoimmunity, asthma, inflammation, arthritis, leaky gut you name it.

https://www.naturalhealthnews.uk/herbal-remedies/2015/01/black-ginger-extract-could-help-control-psoriasis-flares/

Chrysanthemum helps with endotoxemia from infection and leaky gut. It reduces oxidative stress, inflammation and reduces nitrositive stress.

https://www.ncbi.nlm.nih.gov/pubmed/12009031

Camu Camu is very nutritious and high in vitamin C and minerals. It reduces inflammation and oxidative stress. It also increases GABA levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296744/

https://www.sciencedirect.com/science/article/pii/S0914508708001500

I am still uncertain about HDAC inhibitors reducing oxidative stress and increasing things that deal with oxidative stress would be a better route to go. Inhibiting HDAC would be treating the symptoms but not the cause of the illness. Inhibiting it can have such a dramatic effect on the body. HDAC inhibitors have been shown to reduce interstitial cystitis symptoms and symptoms of inflammatory bowel diseases, inflammation and cancer. Inhibiting HDAC increases Ogg1 which prevent cancer and oxidative stress. I have posted on the Nrf2 pathways. Activating Nrf2 stimulates Ogg1.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665669/

https://www.nature.com/articles/srep39257

http://clinical-epigenetics.imedpub.com/histone-deacetylase-inhibitors-updated-studies-in-various-epigeneticrelated-diseases.php?aid=8724

https://cshperspectives.cshlp.org/content/6/4/a018713.full

There are natural HDAC inhibitors. Which help fight cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210916/

https://www.sciencedirect.com/science/article/pii/S0304383518304750

https://link.springer.com/article/10.1007/s12263-012-0283-9

https://www.karger.com/Article/FullText/495275

https://europepmc.org/abstract/med/26482938

Ogg1, increasing Ogg1 fights cancer, excess oxidative stress and reduces risk of cardiovascular disease and other inflammatory diseases. It has been shown to help with autoimmunity. Inhibiting mTOR activates Ogg1. Remember do not over do it we need some oxidative stress to absorb nutrients, fight infection and break down scar tissue in the body.

https://www.nature.com/articles/1202096

https://academic.oup.com/carcin/article-pdf/31/11/2022/7094224/bgq189.pdf

http://www.weizmann.ac.il/Biomolecular_Sciences/Livneh/content/reduced-activity-dna-repair-enzyme-ogg1-associated-increased-risk-lung-cancer-and-head-and

https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.116.308362

https://www.nature.com/articles/s41419-018-0680-0

https://www.sciencedirect.com/science/article/pii/S0959804910006337

https://www.academia.edu/12613796/Antioxidant-mediated_up-regulation_of_OGG1_via_NRF2_induction_is_associated_with_inhibition_of_oxidative_DNA_damage_in_estrogen-induced_breast_cancer

Ogg1 needs folate to function properly. Remember folate and folic acid are not the same folic acid is toxic to the body and is man made. High blood glucose levels and low insulin levels can inhibit Ogg1. I have posted on mTOR inhibitors. Inhibiting mTOR increases Ogg1.

http://cancerpreventionresearch.aacrjournals.org/content/3/1/92

https://www.hindawi.com/journals/omcl/2015/683197/

https://www.tandfonline.com/doi/full/10.1080/15384101.2016.1231259

Ogg1 and MuT Homolog1 are DNA repair mechanism and are upregulated in ulcerative colitis. Oxidative stress increases their expression.

https://www.spandidos-publications.com/ol/16/2/1765

In bladder injury parp is activated. This indicates excess inflammation or excess oxidative stress causing DNA damage because PARP is activated during DNA damage. Excess PARP activation depletes NAD+/ATP which causes cell death. PARP is over activated in some types of cancer. Keep in mind the common ties. Inflammation, what causes it why is it happening? Finding the source and correcting in is how to heal not by treating the symptoms. PARP inhibition can lead to obesity, insulin resistance and glucose intolerance.

https://www.ncbi.nlm.nih.gov/pubmed/18296739

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806654/

https://www.nature.com/articles/s41467-018-03234-8

Excess PARP1 hyperactivation can cause occluding to be down regulated. This is found in tight junction layers throughout the body and can lead to a leaky blood brain barrier, bladder injury, and leaky gut. It has also been linked to Alzheimer’s. It can also lead to stroke, heart inflammation, brain and nerve damage.

http://austinpublishinggroup.com/nutritional-disorders/fulltext/andt-v2-id1018.php

Querciten and Rutin inhbiti PARP with Querciten being the most potent inhibitor. Heat Shock Protein 90 inhibits PARP. This can be stimulate by heat.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896521/

http://www.ijbs.com/v13p0198.htm

C-reactive protein causes inflammation. It is a sign of bacteria infection. If C-reactive levels are high for too long it can damage the bladder and lead to chronic illness like cardiovascular disease, diabetes and autoimmunity. C-reactive levels are high in most chronic illness especially heart disease and interstitial cystitis. It is usually caused by infection yet I have seen many go years with high C-reactive levels and refused antibiotic treatment because they are told they do not have and infection. Those with tick born illness and interstitial cystitis are the ones who are the most victimized by the medical community. In order to reduce C-reactive protein levels you must address the cause which means detoxing if it is caused by something like glyphosate, aluminum, mercury or infection. An anti-inflammatory diet helps. Also often times oxidative stress is involved and needs addressed.

https://www.creative-diagnostics.com/blog/index.php/what-is-c-reactive-protein/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471098/

https://benthamopen.com/ABSTRACT/TONEUJ-6-158

https://www.lifeextension.com/magazine/2014/5/Testing-For-C-reactive-Protein-May-Save-Your-Life/Page-01

If p53 is inhibited ROS increases. This in turn can cause mutant P53 which will have the same effects as inhibited p53. Inflammation inhibits p53. Loss of p53 causes inflammation in the body that becomes unregulated especially in the bladder. Oxidative stress and excess inflammation can inhibit P53 creating a cycle that is difficult to break. Mutated P53 is common in interstitial cystitis and cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256302/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1939966/

https://www.sciencedirect.com/science/article/pii/S0005272809000115

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076779

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135644/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614039/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135644/

Magnets reduce inflammation and improve blood flow. One pole stimulates blood flow and one pole reduces inflammation but I do not remember which pole does which and I cannot find the links to the studies.

https://news.virginia.edu/content/biomedical-engineering-study-demonstrates-healing-value-magnets

This stuff kills cows and sheep and they feed it to us? Really???

Written by Lee Stevenson , sorry I am a lousy editor so there will be error in my grammar.

GMOs are one big lie.

They say we need GMOs because of a shortage of food. That is a lie it is because of greed. Many nations are studying how to deal with the massive amounts of food wastage. They create false fears then offer a false solution.

They claim that BT Toxins in GMOs are safe for human consumption. They say the animals that died from eating them is anecdotal evidence. At what point does it become solid proof? When the corporation lying about it decides it is real evidence ? When the corrupt governments who have been proven to be colluding with the biotech industry to hide the harm they are doing decides the evidence is beyond anecdotal? It has become clear now days that our governments and many of those in them are overcome with greed for power and money. I feel sorry for those who have not been corrupted and are trying to fight for what is right. Why are they not required to test them for safety. Why are they allowed to falsely claim they have been tested when they have not. They claim they have but the studies are so flawed they are invalid. They read more like an advertisement for the biotech industry. Most of the studies they quote to promote GMOs have been retracted or proven to be flawed.

What gets me is the BT Toxin has been found in the human blood stream showing that consuming it does effect the body because the biotech industry claims that cannot happen. They have even found it in the blood streams of infants in mothers wombs. I would like to see if those BT Toxin crystals cause the same ill health effects as oxalates because they are sharp crystal shaped structures. Oxalates cause joint pain especially in the hips, they also cause inflammation throughout the body. Inflammation causes autoimmunity, cancer and chronic illnesses like heart disease and diabetes. I wonder how many out there have joint pain and it is being caused by BT Toxin crystals but since there is no research in it they are probably being told it is in their heads or it is stress. That is allopathic medicines go to solution when they do not have an answer.

BT Toxins have been found to cause genetic alterations in rats that consume them. Since they are making their way into human blood streams there is a good chance that is also occurring in humans. The worst part of it is they are now doing what is called stacking. They are splicing genes from a number of different BT Toxin producing microbes into GMOs making them even more toxic.

There are studies showing the body reacts to BT Toxins the same way the body would react if it was having an allergic reaction. Many believe they are gluten intolerant but it is BT Toxin and glyphosate intolerant that is really the problem. The BT Toxin works by pretty much by destroying an insects gut giving them leaky gut which in humans causes food intolerances and allergies. BT Toxin has been show to deteriorate the mucus membrane in the gut. Now add the toxic effects of glyphosate which does pretty much the same things but can cause gut paresis. BT Toxins have been shown to trigger an inflammatory response in the gut which reduces the gut mucus membrane were our gut microbes that keep us healthy reside. There is no study showing the health effects of this from BT Toxins but there are many studies showing when this happens we develop leaky gut , autoimmunity and chronic inflammatory diseases. Now you can see why inflammatory bowel diseases are rampant now days.

BT Toxin has been found to be toxic to the blood and causes anemia and many other blood disorders. It has been shown to negatively impact the adrenal glands, spleen, liver and kidney. Notice all those types of illnesses have taken a dramatic climb lately.

GMOs have been shown to be nutritionally inferior. When they alter the genes so the plant produces higher amounts of a certain nutrient it causes the plant to produces less of another. The glyphosate and glufonisate they use on them chelate nutrients from the soil and enter our blood stream and chelate nutrients form the body. I believe it is not a coincidence the U.S. government started requiring they fortify food with the very nutrients that those chemicals chelate from the soil and body. The bad part about that is they use synthetic vitamins which are toxic to the body. Folic acid is man made and has been shown to increase the risk of cancer. It builds up in the blood stream causing psychosis and bipolarism because it damages the NMDA receptor. If you search my blog I have posted on it. Folate which is natural has the opposite effects. The sad part is many medical professionals do not know the difference between folate and folic acid. Because they are fortifying foods with iron many in the U.S. have iron toxicity which causes oxidative stress which can lead to cancer and chronic illness and digestive problems.

They have shown that it is possible for the genes from GMOs to transfer horizontally to the gut microbiotia and in animal studies it has happened. Knowing what BT Toxin does to the body can you imagine if our microbiotia is producing BT Toxin adding to the levels of BT Toxin in the bodies of those consuming GMOs. I would like to see someone study that and I would like to see a study on the blood levels of BT Toxins in those who consume GMOs.

GMOs are causing insects and weeds to become resistant to herbicides and pesticides which has increased the need to use those harmful chemicals. This has resulted in the extinction of some insects that polinate. It has brought the monarch butterfly on the verge of extinction and many bees have been put on the endangered species list. Bees are not the only thing that pollinates and the BT Toxin has been killing a variety of pollinating insects.

It is also contaminating the environment because the BT Genes are transferring to plants in the wild. I have posted on how toxic GMOs are if you want to learn more you can read more at this link.

https://iamajuicer.wordpress.com/2018/06/17/genetically-modified-foods-destroy-our-health-glyphaste-and-glufonisate-add-to-the-toxicity/

GMOs are toxic to the body now imagine that combined with glyphosate and other farm chemicals.

https://www.gmoevidence.com/wp-content/uploads/2013/05/JHTD-1-104.pdf

http://www.gefree.org.nz/assets/pdf/joecummins.pdf

http://www.i-sis.org.uk/BTTIGMC.php

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236067/

https://aem.asm.org/content/aem/68/10/4900.full.pdf

https://aem.asm.org/content/68/10/4900.long

Hundreds of studies showing insects build up a resistance to it which means they are now stacking a variety of BT Toxin genes into the GMO crops making them even more toxic to eat. Cattle and sheep have died from eating GMOs. It had a negative impact on rats fed even low doses of GMOs. The most notable are the changes to the rats intestinal system which matches many unexplained digestive disorders many suffer from now days.

https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed_citedin&from_uid=24665719

https://www.ncbi.nlm.nih.gov/pubmed/30024919

http://www.i-sis.org.uk/MDSGBTC.php

https://www.gmwatch.org/en/latest-listing/1-news-items/13926-syngenta-charged-with-lying-over-cattle-deaths

https://www.academia.edu/3138607/Morphological_and_Biochemical_Changes_in_Male_Rats_Fed_on_Genetically_Modified_Corn_Ajeeb_YG_

https://www.academia.edu/3405345/Histopathological_Changes_in_Some_Organs_of_Male_Rats_Fed_on_Genetically_Modified_Corn_Ajeeb_YG_

http://www.ijbs.com/v05p0706.htm#headingA11

https://www.ncbi.nlm.nih.gov/pubmed/10354369

https://www.sciencedirect.com/science/article/pii/S1567576918302467?via%3Dihub

https://www.gmoevidence.com/wp-content/uploads/2013/05/JHTD-1-104.pdf

BT toxin cause an immune response very similar to food poisoning.

https://www.ncbi.nlm.nih.gov/pubmed/19007233

Kills insects.

http://news.cornell.edu/stories/1999/04/toxic-pollen-bt-corn-can-kill-monarch-butterflies

I could list many studies showing that organic crops produce comparable or higher yields at lower cost. Not only that but the herbicides used on them chelate nutrients from the soil and when consumed they enter the blood stream and do the very same thing.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081039

http://news.cornell.edu/stories/2006/07/bt-cotton-china-fails-reap-profit-after-seven-years

Now imagine what the combined effects of glyphosate and BT Toxin does.

https://onlinelibrary.wiley.com/doi/abs/10.1002/jat.2712

https://www.sciencedirect.com/science/article/pii/S0890623811000566?via%3Dihub

https://www.researchgate.net/publication/220043380_Cytotoxicity_on_human_cells_of_Cry1Ab_and_Cry1Ac_Bt_insecticidal_toxins_alone_or_with_a_glyphosate-based_herbicide

BT Toxin in GMO are different then the natural bt toxin. The natural was toxic to humans so imagine consuming it.

https://www.tandfonline.com/doi/full/10.1080/02648725.2017.1357295

http://ddata.over-blog.com/xxxyyy/3/19/57/29/Bacillus-thuringiensis–danger.pdf

They have never been tested for their risk to humans.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209668/

Not only those issues but horizontal gene transfer has been shown to happen which can turn our guts into pesticide factories.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1364539/

https://responsibletechnology.org/gmo-education/section5/

The hype surrounding GMOs is based on research that has been retracted.

https://www.gmwatch.org/en/news/archive/2013/15198-gmo-hype-based-on-retracted-science

There was a hidden viral gene found in GMOs this has happened with vaccinations which has led to new super bugs occuring.

http://www.i-sis.org.uk/Hazardous_Virus_Gene_Discovered_in_GM_Crops.php

They falsely claim they need to save the world from starvation when in reality many nations are trying to figure out how to deal with the massive food wastage.

https://www.nrdc.org/sites/default/files/wasted-food-IP.pdf

https://www.usda.gov/oce/foodwaste/

https://www.npr.org/sections/thesalt/2014/02/27/283071610/u-s-lets-141-trillion-calories-of-food-go-to-waste-each-year

https://www.bloomberg.com/news/articles/2013-02-08/u-s-corn-surplus-estimate-raised-5-on-slowing-global-demand

https://www.agri-pulse.com/articles/3531-u-s-corn-surplus-seen-at-1-63-billion-bushels-down-9-vs-december-estimate

The plants we eat effect our genes can you imagine what GMOs are doing to peoples genes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374554/

Digestion probably more then you wanted to know. Enzymes and bile and stuff.

This is not medical advice I am posting this for informational and educational purposes.

This is not done I have a lot to add to it but I am kind of burned out. I will finis it later after I take a break.

Gastrointestinal motility and digestive enzymes.

This is mostly on bile but I wanted to cover the other areas of digestion before I covered bile.

Inhibited bile causes constipation. Frequent constipation increases Bilophila Wadsworthia which causes appendicitis. Trans-fats and saturated fats should be avoided when bile is inhibited or when constipated because they increase the growth of Bilophila Wadsworthia. Trans-fats should be avoided anyways they are very bad for our health.

Most know how digestion works but we need a refresher. When we chew our food it is mixed with saliva which has some digestive enzymes in it. When we swallow it is propelled down the esophogus where it is mixed with enzymes and gastric acid. The end result is called chyme. The chyme is pushed into the small intestine (duodenum). Many will ask me how to increase bile production but doing so could cause more harm then good. The problem causing the inhibited bile flow needs to be addressed. For example a dam can only hold so much water. If there is more water then the dam can hold it will flood over the top. Adding more water to the dam adds to the problems and could break the dam. When there is a blockage causing bile flow to be inhibited then increasing bile would be like adding water to a dam that is already overflowing. Most health issues mentioned in this article I have discussed elsewhere on my blog.

Peristalsis is the movement of food through the digestive system. It is the cause of the gurgling sound you hear when you are hungry or digesting food. Usually you cannot hear it. I do not know why but I and my friends experienced this. As we healed our digestive system you could feel the food moving and the sounds of digestions were very loud. As we healed they became quieter and quieter.

In the small intestine the food is combined with bile and pancreatic enzymes to break it down further and for nutrient absorption. The smooth muscle in the intestines are ring shaped and alternate between contracting and relaxing. This causes the food to move slow enough through the digestive tract for it to be broke down and for the nutrients to be absorbed. The neurons are stimulated by acetylcholine, and substance P to get them to contract. Nitric oxide, vasoactive peptide and ATP relax the muscles. This causes a motion that moves the food through the digestive tract and occurs the most in the small intestine. There are health issues that can cause a high acetylcholine and high substance P levels. High noradrenaline reduces substance P which can interfere with intestinal motility and can lead to constipation. High estrogen levels can inhibit substance P. High substance P levels can cause inflammation and lead to inflammatory bowel disease. There are health issues that can cause low acetylcholine and low serotonin levels. This also will cause a loss of motility leading to constipation. An imbalance in our immune system can cause bile flow to be inhibited. Estrogen inhibits bile flow and progesterone pormotes bile flow. This causes the liver and thyroids to become sluggish. This can also lead to interstitial cystitis. All the above mentioned things can inhibit receptors and throw hormones out of balance. If not addressed it will become chronic and start a cycle that is difficult to break and can take months to years to heal from.

https://www.selfhacked.com/blog/substance-p-roles/

If the gurgling in the gut is excessive and there is cramping, abdominal pain, and possibly nausea and vomiting it could indicate slow gut motility or a blockage. This can be caused by intestinal damage, hormone imbalance, inflammation in the intestines, dysbiosis, candida overgrowth, a deficiency in certain gut microbiota, slow or inhibited bile. This causes gas, bloating, and distention (inflammation in the gut). If we have a T cell imbalance or high B cell levels this can also cause it. If not addressed it can result in a decline of intestinal health our the health of the body. High histamines can cause inflammation that can cause blockage. We do not want to inhibit them because histamines are needed to stimulate gastric acid. It is best to work on reducing them.

If the digestive system is injured and we do not give it the things needed for it to heal then it loses the ability to sense nutrients and food that has entered it so it cannot respond to them. The longer it goes like this the worse it gets and the longer it will take to heal.

Bile acid is needed for the healthy brown fat to be produced. Bile acid is synthesized form cholesterol. Excess oxidative stress or inflammation in the liver can cause low cholesterol levels or can inhibit it’s production which would prevent the bodies ability to produce bile properly. This can also cause bile to become inhibited. When this happens bile production is reduced and it becomes thick. Phosphatydylcholine is needed to store bile in the gallbladder. I have found most who have problems with choline metabolism have benefited from sunflower seed oil. Excess oxidative stress can cause methionine and choline to become depleted. This inhibits the bodies ability to produce bile.

Enzymes.

If you are deficient in certain enzymes often times there are plants you can consume that will helps digest foods that require those enzymes.

Lactase- (B-Galactosidase)- deficiency causes lactose intolerance. It breaks down Lactose down to glucose and galactose. Damage in the gut can cause it to not be reabsorbed. If this happens the gut microbiome will break it down causing gas and bloating. Those who are lactose intolerance will usually also be intolerant of FODMAPS until they get their gut healed enough to correct the malabsorption issues. Those who have malabsorption issues may benefit from taking Lactase when consuming dairy products. Saccharmyces Boulardii has been found to increase enzyme function in those with Lactose and FODMAP intolerance. If a person is lactose intolerant if they avoid dairy products while supplementing galactooligosaccaride for about a month, it has been found to increase Lactose metabolizing bacteria which prevents the bloating and ill effects of lactose. Also slowly introducing dairy into the diet a little at a time can increase the gut microbes that produce lactase. That would prevent a reaction to lactose also.

Alpha-galactosidase- helps break down digested fats and saccharides a deficiency causes lysosomal storage diseases. If defficient in Alpha-Galactosidase when eating fiber and high sulfur foods a person will develop gas and bloating. Those who have a deficiency in Alpha-galcatosidase will be intolerant to complex carbohydrates and may be intolerant to gluten. Beans will be a problem for a person lacking this. Infection can cause A-gal to be inhibited from the LPS produced. Inducing autophagy can testore A-gal. Tick born illness can cause autoimmune disease that can cause the body to make antibodies against a-gal. Balancing the immune system is very important. If not addressed it can lead to a sensitivity to meat.

Things that help with lysosomal storage disease should help with this. https://iamajuicer.wordpress.com/2018/08/21/things-that-may-help-with-lysosomals-storage-disease/

Sucrase- secreted in the small intestine. Catalyzes sucrose , fructose, and maltose. A deficiency will cause lactose intolerance, gas , bloating and diarrhea when things containing sucrose are consumed. Inflammation can cause it’s excretion into the small intestine to be inhibited. Sucrase is also known as invertase. Thyroid hormones and corticosterone stimulate sucrase and maltase. Inflammation and intestinal damage will decrease it’s secretion. High CD8 T cell levels inhibit Sucrase. I have posted on balancing T cells.

Amylases-work with other enzymes to break down polysaccharides. It is the major form of amylase found in humans and breaks down starch to maltose and dextran. It prevents bacteria from producing biofilms by breaking them down. It is secreted in saliva and from the pancreas.

endopeptidase (enterokinase) that breaks down proteins into smaller peptides (it is a protease) It is produced in the stomach and is one of the main digestive enzymes. It transforms trypsinogn into trypsin. procarboxypeptidase into the active enzyme carboxypeptidase which is involved in the maturation of proteins produced. Carboxypeptidase is also involved in enzyme and hormone production throughtout the body. It is produced in the mucus membrane showing the importance of restoring the health of the mucous membrane. This can result in protein and enzyme deficiencies in the body.

Trypsinogen- is the precursor form of trypsin it is found in pancreatic juice that is released in the small intestine. Trypsinogen is activated by the protease enteropeptidase which is produce by the mucus of the duodenum. Trypsin breaks down proteins to ammino acids.

Chymotrypsinogen- precursor for chymotrypsin. It is activated by trypsin.

Pancreatic Lipase- It is secreted into the small intestine in it’s completed form. But it only becomes effective in the presence of colipase which is a co-enzyme.

Phospholipase-converts lipids(fats) to phospholipids.

Lipase-breaks down triglycerides to fatty acids and glycerol. Deficiency causes a lack of fats needed by the body and fats in stools. Lipase also protect the body from parasites and pathogens. If deficienct a person will suffer from malabsorption. There are microbe derived lipases that have been shown to be effective for Lipase deficiency.

Na+ Taurocholate Cotransporting Polypeptide (NTCP) is used by the liver to extract BA returning to the lever through the portal vein. Should not be stimulated in those with cholestasis it can damage the liver. A deficiency causes muscle weakness. If it is inhbited bile salts can build up in the liver resulting in liver damage. This also results in an increase in blood levels of bile acids.

Pancreatic Polypeptide self-regulates pancreatic secretion activities. It’s secretion is increased from protein consumption, fasting, exercise, and is decreased by glucose and somatostatin. It can inhibit gallblader contractions and pancreatic exocrine secretion.

Pancreatic Elastase – help finish breaking down foods. If there is excess oxidative stress , inflammation or immune imbalance that effects the pancreas it can inhibit pancreatic enzyme secretion. They usually test for this enzyme in stool to see if the pancreas is functioning properly.

Digestive hormones.

Most of these hormones are effected by our brain especially the hypothalamus. If we have endotonins, heavy metals , glyphosate or other toxins that effect the brain then our digestion will be effected which further effects our brains. The hormone imbalance causes mental issues. They can be corrected if you address what is causing the imbalance. Many will take medications, which only treat the symptoms. Most medications for those types of things effect digestive hormones adding to the problem. Then when a person starts correcting the problem their mental issues become worse because of the drugs they are taking and the body starting to function correctly will swing hormones in the other direction. When the digestive system is damaged our cells that produce hormones become less numerous. We must try and protect the so healing can begin. Also nerve cells become less numerous which makes our bodies digestive responses to be much lower. Regular and electric acupuncture have been shown to help restore normal hormone levels. Bile acid also regulates lipid and glucose homeostasis. If bile acid become inhibited Thyroxine (T4) levels increase and Tiiodothyronine (T3). Low T3 levels inhibits oxidation which is needed to use lipids and cholesterol in the body. This will cause low LDL levels and high HDL level. Low T3 levels inhibits the bodies ability to synthesize proteins. Insulin loses it’s ability to inhibit glucogenesis. This cause glycolysis to be inhibited. This also effects the heart and can cause heart palpitations. High T4 levels can cause a decrease in serotonin.

Ampulla of Vater blocakge– inflammation, oxalates, toxins, infection or damage in the body can lead to pancreatic enzymes building up causing the pancreas to digest itself.

If you have blockage inhibiting enzyme secretion I would not advice stimulating the secretion until the health problems causing the blockage have been addressed.

When we have metabolic issues, inflammation or any other of the health issues I have describe these enzymes can be effected. Especially if we have damage to our digestive system.

Serotonin – (5-HT) regulates gut motility. It is produced in the mucosa of the gut. It increases peristalsis (movement of food through digestive tract). It has been found to be low in those with inflammatory bowel diseases. A deficiency can cause gastroparisis and bile reflux. It also stimulates adenylyl cyclase which is involved in cell signaling throughout the body. Most drug agonist of the 5-HT receptors damage the liver and heart. Acupunture stimulates serotonin. There are some disorders which inhibits 5-HT from exiting the cells. This causes a build up in the cells and a person will be senstitive to 5-HT but would still have symptoms of 5-HT deficiency.

Motilin – triggered by fasting, and fatty foods. Controls peristalsis by stimulating smooth muscle contraction and relaxation to coordinate the movement of food through the digestive tract. The antibiotic erthromycin stimulates motilin. Motilin had been found to be low in those with inflammatory bowel diseases. Acupuncture increases motilin. Motilins effects are influenced by PH. Low PH motilin inhibits gastric motility at higher PH it stimulates gastrointestinal motility. Food intake slows the production of motilin. Insulin also inhibits the secretion of motilin.

Reflux can be cause by bile issues in two ways. If there is a blockage a person could experience bile acid reflux. If there is insufficient bile production the the acid from the chyme does not get neutralized by the bile and will cause acid reflux. L-taurine and betaine also known as TMG helps with bile production. Cysteine is also needed and taking NAC (N-acetylcysteine) about three times a week has been found to help. If it is taken more then that the benefits are lost.

Gastric Inhibitory Peptide – triggered by glucose and fatty foods. Decreases gastric emptying and stimulates the release of insulin. It promotes fat storage.

Vasoactive Peptide – increases blood flow to the gut, supplies eleyctrolytes to pancreatic enzymes and bile.

Guanylin – causes secretion of chloride , decreases absorption of water from the gut. It prevents the sodium levels from the body from getting too high by inhibiting salt absorption and by stimulating the secretion of bicarbonate and chloride.

Glucagon – glucagon supresses CYP7A1 which reduces bile production. This can lead to insulin resistance and glucose intolerance. Glucagon prevents blood sugar levels from getting too low. It is involved in gluconeogenesis which produces glucose form proteins.Glucagon also breaks down fat stores in the blood stream. Excess glucagon leads to diabetes and thrombosis.

Glucagon Like Protein-1 (GLP-1) Whey protein increases GLP-1, glucose also stimulates GLP-1. Slows down digestion. It increases the size and health of pancreatic B cells. Stimulates brain repair. It’s release is stimulated by TGR-5. GLP-1 is involved in appetite suppression and glucose homeostasis. Low levels causes glucose deficiency. Carbohydrates and elevated blood levels of proteins helps stimulate glucagon . If we are deficient in glucagon glycogen can build up in the livers. It brings down glycogen in the liver by breaking it down to produce glucose. Somatostatin inhibits glucagon production. Excess glucagon cause weight loss and deficiency causes weight gain. Fasting stimulates glucagon production.

Secretin- helps regulate water homeostasis in the body, helps regulate the PH of the small intestine by gastric acid. Secretin inhibits gastic acid production and stimulates the production of bicarbonate. Secretin also stimulates bile production. It is produced mainly in the mucosa of the small intestine and jejunum. It is release from the low ph caused by chyme entering the small intestine.

Secretin deficiency causes a loss of neural progenitor cells. Progenitor cells are similar to stem cells. Since secretin increases neural progenitor cells it helps with autism, motor coordination and improves memory. Secretin helps with asthma by acting as a bronchorelaxer. Secretin reduces symptoms of pancreatitits.

In order to function properly levels of cholecystokinin and insulin need to be normal. If they are dis-regulated it effects secretin levels. It also stimulates polyamines in the pancrease which is needed for cell growth. Polyamines also regulate ion channels including the NMDA recemptors, AMPA receptors and potassium channels. Excess polyamines can cause the blood brain barrier to become more porous. Showing the importance of secretin homeostasis. When H Pylori in in it’s pathogenic form it will cause a secretin deficiency. Secretin promotes the production of mucus. A decrease in secretin decreases the function of angiotensin 2. Secretin increases thirst. Secretin increases the feel good hormone oxytocin.

Now the bad if a person has bile blockage like cholestasis it can cause liver damage. I discuss things that can help with that at the end of this blog post. Secretin causes Zollinger-Ellison syndrome to worsen.

High levels of somatostatin inhibits secretin.

Cholecystokinin- stimulates the release of digestive enzymes and bile from the pancrease and bladder. Whey protein stimulates CCK. Fat intake also stimulates CCK. A deficiency in CCK causes malabsorption and can lead to Type 1 diabetes. Damage to the mucus membrane can cause a deficiency. This can also be caused by autoimmunity. This is where a dilemma occurs. High levels of bacteroidetes or high levels of methane producing bacteria can inhibit CCK. Protein stimulates CCK. I believe working on bile blockage and then once that is corrected increasing bile flow first to reduce the bacteroidetes levels and methane producing bacteria then adding protein into the diet once they are reduced would most likely correct the problem along with restoring the health of the mucus membrane.

Intrinsic Factor-important in the absorption of vitamin B12. Often times B12 deficiency is caused by a lack of the microbiota that produce B12 but is mistakenly attributed to and intrinsic factor deficiency.

Haptocorin-binds to B12 in our food protecting it from our gastric acid so it can survive the stomach. It is found in our saliva. This shows the importance of making sure we chew our food very well.

Gastrin- hormone that stimulates gastric acid secretion. It is released from the pariental cells in the stomach. It also aids in gastric motility. Elevated gastrin can cause hypergastrinaemia. Low levels can cause hypergstrinaemia. Infection can effect gastrin levels and so can histamines. Histamines are needed for Gastrin stimulation if histamine levels are too low the we will not produce enough stomach acid. If they are too high then we can get acid reflux. If someone is not producing enough acid then they most likely have low histamines and would benefit from fermented foods and aged meats which are high histamine.

Gastric inhibitory polypeptide- an inhibiting hormone of the secretin family. It stimulates insulin secretions based on how much glucose is present. It stimulates glucagon secretion and fat accumulation. It is found in intestinal mucus, small intestine, and jejunum of the gastrointestinal tract. Has many other functions throughout the body including bone growth.

Vasoactive intestinal peptide- serves functions throughout the body but relaxes smooth muscles in the trachea, gall bladder and stomach.

Bombesin- stimulates gastrin release from the pancrease. It also stimulates adrenal and pituitary hormones. It increases the thickness of the mucus membrane. It modulates the neural firing rate in the intestines so is involved with gastrointestinal motility.

Somatostatin reduces histamines which will reduce the gastric acid stimulating effects of histamine. In those with inflammatory bowel issues somatostatin in usually very high. Acupuncture has been shown to reduce somatostatin. Most lactobacillus bacteria will reduce somatostatin. Somatostatin prevents the over production of certain hormones in the body. If there is excess somatistatin it will inhibit hormones especially insulin. Somatostatin inhibits glucose and fat absorption. It inhibits insulin and glucagon in the liver. It stimulates muscle contractions in the intestines speedingup transit times. Protein stimulates somatostatin.

Cholecystokinin, glucagon-like-peptide, gastrin-releasing peptide stimulate somatostatin.

Substance P, insulin, pancreatic polypeptide, and opioids inhibit somatostatin.

Excess somatostatin inhibits bone growth, disrupts sleep, and increases dopamine, norepinephrin and epinephrine.

High levels somatostatin will cause high thyroid hormone levels because it inhibits thyroid stimulating hormone which senses hormone levels and shuts them down if they get too high. This causes weight loss no matter how much a person consumes , flushing or hot flashes, and heart palpitations.

Insulin- breaks down blood glucose. Excess insulin can lead to cancer and many other health problems. Glycoproteins increase insulin. Whey protein increases insulin and reduces blood glucose levels. This is one that confuses me and makes me believe those with inflammatory bile have blockages. Many with inflammatory bowel have high insulin levels which stimulates CYP7A1 which should increase bile production and still they have low bile flow and often times CYP7A1 levels are low. It may be that inflammation is inhibiting the receptor.

Ghrelin-triggered during hunger or calorie restriction. Stimulates appetite. Whey proteins increases Ghrelin. Ghrelin is involved with gastric emptying.

Deacyl-ghrelin – DAG decreases gastric emptying, induces postprandial fullness and improves insulin sensitivity.

Peptide YY- secreted after eating it cancels out the effects of ghrelin.

Pheonixin – expressed in the hypothalamus, it stimulates appetite.

Peptide YY- produced in the gut where short chain fatty acids are produced. Proprionate and butyrate increase expression of Peptide YY. It reduces appetite. It is stimulated from the consumption of fiber from fruits and vegetagles. It also reduces pancreatic secretion.

Leptin – regulates body fat.

http://www.jnmjournal.org/journal/view.html?uid=1395&vmd=Full&

Bile Acids

Bile stimulates the secretion of electrolytes and water into the intestines which stimulates digestion. Biles acid stimulates the release of 5-HT. Those with inflammatory bowel diseases have been found to have high levels of bile acids Taurocholic Lithocholic Acid, Taurocholic acid and Taurocholic Deoxycholate.

Bile acid promotes liver regeneration by activiating BA recperors Farnesoid X receptor and G-Protein-coupled BA receptor1 (GPBAR1 or TGR5) . This shows the importance of bile acid homeostasis. Proper bile acid production is very important for maintaining a balanced gut microbiome.

Inhibited bile can cause gall stones and lead to liver and kidney disease.

There are many things that can inhibit bile production. Inflammation, toxins, metabolic issues, especially inhibited receptors involved with bile production. Infections can cause bile to become inhibited and so can the endotoxins they produce. If we develop leaky gut the LPS (lipopolysaccharide) which is produced by pathogens and our commensals can enter the blood stream. Our microbiome uses LPS to communicate with our bodies but when it gets into the blood stream it causes the same problems a pathogen would. We also have commensal microbes that break down LPS antibiotics and farm chemicals especially glyphosate and glufonisate can kill our gut microbiome. They modulate most organs in our bodies including our brains. They even modulate some of our genes. Without them we will not have an immune system and we cannot restore the body to homeostasis. Metabolic issues can cause acidosis or alkalosis which will also interfere with the propper function of our organs and causes a lot of damage which progresses and becomes more severe if the problems causing them are not addressed. Infection can also change the PH of the body. There is a myth that alkalizing the body will make us healthier. This is not true but it promotes things that are usually commensal like Candida and H Pylori to turn pathogenic. If a person has candida and H Pylori problems they most likely have high ammonia levels. This causes BH4 to become depleted increasing the ammonia levels even more. If not addressed they will start having problems eating high protein foods and high sulfur foods. Another thing that can cause blockage that effects bile flow is oxalates. They can be produced endogenously or we can get them exogenously. If we have leaky gut oxalates that are usually excreted in our feces can easily enter our blood stream. Also many will consume a lot of raw greens. Spinach and Kale are very high oxalate and can increase oxalates in the body. We have oxalate degrading microbiota and if antibiotics or farm chemicals in our food kills them our oxalate levels can indrease. I have posted on my blog on how to deal with those issues.

Bile, an aqueous solution produced and secreted by the liver, consists mainly of bile salts, phospholipids, cholesterol, conjugated bilirubin, electrolytes, and water.The liver cells are mostly hepatocytes. Bile travels through the liver in a series of ducts, eventually exiting through the common hepatic duct. Bile flows through this duct into the gallbladder where it is concentrated and stored. When stimulated by the hormone cholecystokinin (CCK), the gallbladder contracts, pushing bile through the cystic duct and into the common bile duct. CCK is usually deficient in those with inflammatory bowel disease. Cholecystokinin is released after a meal is consumed. It is stimulated by the production of stomach acid. It is secreted along with secretin. Secretin stimulates bicarbonate in response to the acid from the chyme that enters the small intestin, and It stimulates pancreatic enzymes and forces bile into the small intestine. If we do not produce enough stomach acid then Cholecystokinin is not released and our food will sit in our stomach and ferment. This causes and increase of either methane producing bacteria or sulfur digesting bacteria. Methane and sulfur digesting bacteria cause lower motility in the intestines slowly digestion even more. Bile is needed to stimulate the Vitamin D Receptor.

Simultaneously, the sphincter of Oddi relaxes, permitting bile to enter the duodenal lumen. Lumen is the space in a tubular shape. The hormone secretin also plays an important role in the flow of bile into the small intestine. By stimulating biliary and pancreatic ductular cells to secrete bicarbonate and water in response to the presence of acid in the duodenum, secretin effectively expands the volume of bile entering the duodenum. In the small intestine, bile acids facilitates lipid digestion and absorption. Bile is needed to absorb many nutrients especially lipid (fat) soluble vitamins like Vitamin D, Vitamin E, , Vitamin A and Vitamin K. Only approximately 5% of these bile acids are eventually excreted. The majority of bile acids are efficiently reabsorbed from the ileum, secreted into the portal venous system, and returned to the liver in a process known as enterohepatic recirculation. Ileum is the final section of the small intestine.

If bile becomes inhibited it inhibits the vitamin D receptor further inhibiting bile production and adding to the problem because cholesterol production and conversion becomes inhibited. This will make bile become sludgy leading to low bile flow which will increase estrogen levels and cause high unbound copper levels in the blood. Bitter herbs increase bile flow but the vitamin D receptor has to be addressed along with balancing the microbiome in the gut and healing the intestinal tract. Inflammation needs to be reduced , and prevent thrombosis. There are many things that can block the portal vein. The above mentioned things and also thrombosis can cause it. Thrombosis is blood clotting.

This is why I often times recommend grape seed extract and bacopa to people. It prevents thrombosis. Inflammation because endotoxins can cause thrombosis. Grape seed extract and bacopa reduce inflammation and prevent thrombosis. If thrombosis occurs in the portal vein it will effect the liver, pancrease, and digestive system. This causes pain in the stomach, bloating, inflammation, pancreatic pain, pain in the gallbladder. This can lead to death. Bile flow will become inhibited speeding up the progression of portal vein thrombosis. Those with hepatitis need to use hawthorne or something else. Resveratrol activates hepatitis.

portal vein thrombosis

gastrointestinal symptoms (ex: abdominal pain, nausea, vomiting, and diarrhea), fever and constitutional symptoms (ex: fatigue, malaise, and anorexia/weight loss) [3]. We can also find hepatomegaly with elevated liver enzymes and jaundice [3], when associated with liver abscess or cholangitis [2]. Laboratory tests usually demonstrate elevated markers of inflammation [2]

https://www.journalmc.org/index.php/JMC/article/view/3050/2378

If not addressed in time it can lead to portal hypertension. This results in brain swelling, abdominal swelling . Confusion, anemia and low white blood cell count.

https://my.clevelandclinic.org/health/diseases/4912-portal-hypertension

How Bile is Formed.

Bile is produced by hepatocytes, which is then modified by the cholangiocytes lining the bile ducts. The production and secretion of bile require active transport systems within hepatocytes and cholangiocytes in addition to a structurally and functionally intact biliary tree. If this becomes blocked by stones from poor bile production, oxalates or infection a person can develop choledocholithiasis. This will cause problems with the gall bladder, liver, kidneys and digestion. This can also lead pancreatic problems. The symptoms are upper abdominal pain, nausea and vomiting.

Initially, hepatocytes produce bile by secreting conjugated bilirubin, bile salts, cholesterol, phospholipids, proteins, ions, and water into their canaliculi (thin tubules between adjacent hepatocytes that eventually join to form bile ducts). Unconjugated bile is when heme is released during red blood cell break down, the remainder is converted to unconjugated hemoglobin. This form of bilirubin travels from the blood stream to the liver. If the liver cannot convert unconjugated to conjugated it will build up in the blood and a person will develop a yellow like glow. It is normally excreted through the intestines. If there is a rapid destruction of blood cells this can also happen. Infections, toxins, excess vitmin C and excess iron can cause the red blood cells to break down. Conjugated bilirubin is water soluble and if there is a blockage it will be excreted in the urine. Testing for high bilirubin in the urine can help identify blockage.

The canalicular membrane of the hepatocyte is the main bile secretory apparatus which contains the intracellular organelles, the cytoskeleton of the hepatocyte and carrier proteins. Fluctuations in cytosolic and organelle Ca2+ following glucagon or epinephrine stimulation play a major role in hepatic control of glucose production, bile fluid movement and excretion, fatty acid, amino acid and xenobiotic metabolism, protein synthesis and secretion, cell cycle and cell proliferation, among other functions. I discussed in some of my other post about autophagy. It can help issues like this.

The carrier proteins in the canalicular membrane transport bile acid and ions. Transporter proteins found within the canalicular membrane use energy to secrete molecules into bile against concentration gradients. The citric acid cycle is involved in providing the energy for this to occur. Mitochondrial disfunction and a loss of ATP can also interfere with this process. If this occurs cholestasis can occur causing a backup of bile and it can enter the blood stream. If the problem causing the obstruction is not addressed it can lead to fibrosis and vanishing bile duct syndrome. Symptoms are frequent itchy skin, elevated triglycerides, fat growths that appear under the skin. Drugs are often times the cause especially fluorquinolones.

Through this active transport, osmotic and electrochemical gradients are formed. When conjugated bile salts enter the canaliculus, water follows by osmosis. The electrochemical gradient allows for the passive diffusion of inorganic ions such as sodium. The most significant promoter of bile formation is the passage of conjugated bile salts into the biliary canaliculus. The total bile flow in a day is approximately 600 ml, of which 75% is derived from the hepatocyte, and 25% is from the cholangiocytes. Approximately half of the hepatocyte component of bile flow (about 225 ml per day) is bile salt-dependent and the remaining half bile salt independent. Bile Salts are formed in the body by combining bile acids and alcohol sulfates. Bile acid is combined with glycine or taurine to form bile salts. This is a good article explaining how to increase bile salts and the benefits of doing so. Taurine has been found to increase sulfur digesting bacteria which would increase H2S which can inhibit bile production. The is most likely why the western diet causes health problems it is high in taurine.

https://draxe.com/bile-salts/

Osmotically active solutes such as glutathione and bicarbonate promote bile salt independent bile flow. Canaliculi empty bile into ductules or cholangioles or canals of Hering. The ductules connect with interlobular bile ducts, which are accompanied by branches of the portal vein and hepatic artery forming portal triads. Bile is subsequently modified by ductular epithelial cells as it passes through the biliary tree. These cells, known as cholangiocytes, dilute and alkalinize the bile through hormone-regulated absorptive and secretory processes. The hormones are scecretin, acetycholine, ATP, and bombesin. So you can see the importance of making sure we address any issues we have that can inhibit acetylcholine production or cause ATP to become depleted. Issues with glycolysis can cause a loss of ATP. I do not know much about increasing ATP except that creatine helps increase ATP production.

The cholangiocytes have receptors which modulate the bicarbonate-rich ductular bile flow, which is regulated by hormones. These receptors include receptors for secretin which regulates water homeostasis, somatostatin decreases stomach acid production, cystic fibrosis transmembrane conductance Regulator (CFTR) not sure how to describe this one. It is kind of an ion channel/ABC transporter and chloride-bicarbonate exchanger this is where electrolytes are important. These are listed in order of importance sodium, calcium, magnesium and postassium .

For example, when secretin stimulates receptors in the cholangiocyte, a cascade is initiated which activates the CFTR chloride channel and allows the exchange of bicarbonate for chloride. In contrast, somatostatin inhibits the cAMP synthesis within the cholangiocytes causing the opposite effect. While bombesin, vasoactive intestinal polypeptide, acetylcholine, and secretin enhances bile flow, somatostatin, gastrin, insulin, and endothelin (endothelin are involved in electrolyte homeostasis) inhibit the flow. I do not have enough experience with reducing insulin levels and had to have a friend help me with that on facebook. Some metabolic disorders can cause low glucose levels and high insulin levels. It can be corrected but takes someone who is knowledgeable.

Bile Acids Cholesterol catabolism by hepatocytes results in the synthesis of the 2 major primary bile acids, cholic acid, and chenodeoxycholic acid. This process involves multiple steps, with cholesterol 7alpha-hydroxylase (CYP7A1) acting as the rate-limiting enzyme. It is effected by steroid hormones, inflammatory cytokines, insulin and growth factors.

Primary bile acids undergo dehydroxylation by bacteria in the small intestine, forming the secondary bile acids deoxycholic acid and lithocholic acid, respectively. Deoxycholic acid breaks down fats. High protein diet increases deoxycholic acid. Excess lithocholic acid speeds up aging and is carcinogenic. Eating lost of fiber reduces lithocholic acid. Artichoke reduces lithocholic acid and stimulates bile production. If the vitamin D receptor is inhibited then lithocholic acid cannot be detoxed by the body.

Both primary and secondary bile acids are conjugated by the liver with an amino acid, either glycine or taurine. Conjugated bile acids are known as bile salts. Bile salts inhibit cholesterol 7alpha-hydroxylase (CYP7A1) , decreasing the synthesis of bile acids. Despite the increased water solubility of bile salts, they are amphipathic molecules overall (has both hydrophobic and hydropholic molecules). This critical property allows them to effectively emulsify lipids and form micelles with the products of lipid digestion. The bile acid pool is maintained via mainly the enterohepatic circulation and to a small extent (about 5%) by hepatic synthesis of bile acids, as long as the daily fecal loss of bile acids do not exceed 20% of the pool. Micelles help with fat absorption.

Venous blood from the ileum goes straight into the portal vein, and hence through the sinusoids of the liver. Hepatocytes extract bile acids very efficiently from sinusoidal blood, and little escapes the healthy liver into systemic circulation. Bile acids are then transported across the hepatocytes to be resecreted into canaliculi. The net effect of this enterohepatic recirculation is that each bile salt molecule is reused about 20 times, often two or three times during a single digestive phase. When the digestive system is healthy bile gets easily reabsorbed.

Chenodeoxy cholic Acid and Cholic Acid are the primary bile acids produced. From Chenodeoxy cholic Acid many other bile acids are produced.

Bile acid gets reabsorbed and returned to the liver to be recycled. There are secondary bile acids produced in our digestive tract by our gut bacteria. Our microbiome deconjugates bile. Deoxcycholic Acid is a secondary bile acid produced by our microbiome. It is recycled by the body and is conjugated with glycine or taurine and circulated with primary bile acids. It constitutes about 20% of biles acids.

Lithocholic Acid is a secondary bile acid. It is conjugated with glycine or taurine and sulfated producing sulfolithocholylglycine or sulfolithocholyltaurine. Lithocholic Acid is toxic and can destroy the liver. Sulfation is an important part of detoxing deconjugated bile acids. Sulfation of bile acids decreases their absorption rate which prevent them from reentering the liver so when sulfation is functioning properly then the body can easily detox the toxic bile. Sulfation can become inhibited by metabolic issues, high sulfur digesting bacteria raising hydrogen sulfide and sulfide levels in the body. If there are problems with the CBS or BH4 pathways sulfation can be effected. The SULT genes are effected by our hormones. A change in our gut bacteria, toxins, glyphosate, vaccine injury, infections, leaky gut and many other things can change our hormone levels. This can inhibit the ability for the liver to sulfate bile acids. The pregnane X receptor also know as the xenobiotic sensing nuclear receptor has been found to be inhibited in those with bile blockage disorders. Inhibited PXR can inhibit SULT genes. Those with upregulated PXR have been found to be protected from the negative effects of LCA. Constitutive Androstane Receptor (CAR) is involved in sensing and removing endobiotic, and xenobiotic substances. It detoxes foreign substances and drugs. It has be found to protect form LCA when upregulated by inducing SULT genes. CAR is also involved in energy homeostasis. Fasting can induce CAR. Vitamin D receptor, Liver X receptor, and Farnesoid X receptor are also involved in sulfation and upregulation hve been found to protect from LCA. Most of those receptors have been found to be inhibited in those with bile blockage. Showing the importance of supporting their proper function.

When there is an obstruction biles acid can spill over into the blood stream through OST a and b transporters and also can enter the blood through Multidrug Resistance-associated proteins M1M3,M4 and M6. When there is an obstruction urinary excretion of bile is the primary route of bile removal. If this continues for an extended period of time it can lead to bladder irritation from the caustic effects of the bile acid to the bladder. Constipation form inhibited bile flow is common in interstitial cystitis. This can also take place through the organic acisd transporter.

This is an interesting article on bile acid blockage. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1105662

When Lithocholic Acid cannot be sulfated it remains toxic. Lithocholic Acid is highly carcinogenic and causes cancer. High Lithocholic Acid levels inhibits cortisone production this can cause many health issues including chronic fatigue.

Cellulose has been found to increase the mucus membrane which improves bile flow.

Not sure where to go with this information but took note of it. High nitrogen levels increases bile acid oxidation, high hydrogen levels inhibits bile acid oxidation.

https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13064

Medium Chain Fatty Acids stimulate bile production which decreases bacteroides and actinobacteria which has been found to be high in those with dysbiosis and inflammatory bowel disease. Low bile acid production increases levels of microbes that produce potent LPS. Tempo a product made from fermented soy has been shown to reduce bacteriodes and inhibit our microbes ability to produce bile salt hydroxolase which inhibits FXR receptor. By decreasing our microbes bile salt hydrolase bile production is restore which reduces the bacteria that inhibit bile flow. If you try this route you would want to use organic because the BT-Toxin and glyphosate found in soy products destroy the gut and alter our gut microbiome causing an increase in microbiota that have a negative impact on our health. The FXR receptor is responsible for homeostasis throughout the body. If the FXR receptor is inhibited a person will develop diabetes, dislipademia, cancer, metabolic disorders, atherosclerosis and renal diseases.

If a person has cholestasis stimulating bile will damage the liver and cause excess bile to enter the blood causing many other health problems. If a person has cholestasis they should not stimulate bile production. Elevated bile production is a sign and symptom of sepsis which indicates cholestasis.

Things that can cause cholestasis is drugs, infection, metabolic issues, gene issues, gut dysbiosis,inflammatory bowel diseases,hormone imblance, T cell imbalcance, excessive inflammation, toxins and many other things. If a person has cholestasis they will have dark colored urine and light colored stools. Pain in the abdomine, excessive itching, fatigue and nausea. In more severe cases the skin and eyes my get a yellow color.

You have to address the cause of cholestasis if it is drug induced then you may have to discontinue the use of the drug, address infection and inflammation, correct metabolic issues and gene issues. Work on reducing gall stones and oxalate stones.

Some things found to help with bile blockage. Gaur Gum, milk thistle, dandelion, vitamin K, Vit D, Calcium but we must make sure we get the right type, sunflower seed lecithen, antioxidants but do not over use homeostasis is the goal. We need some oxidative stress if we completely disable ROS we will defeat the purpose. Radishes have been shown to help with bile blockage. Cod liver oil helps with bile blockage, medium chain fatty acids help with bile blockage, curcumin helps with bile blockage but after a while it should be pulsed because it chelates iron from the body and can cause anemia. Activated charcoal helps with cholestasis but should not be taken close to meals or we will lose nutrients. Soaking in epsom salt and then getting far infrared, sunlight or halogen light gives us magnesium sulfate which helps with cholestasis. If it is caused by gall stones apple juice and apple cider vinegar has been found to reduce gall stones. Lemon juice has been found to reduce gall stones. I had to put lemon juice in water because straight lemon juice was to strong for me and made my stomach hurt. Artichoke has been found to reduce gall stones. We need a variety in our diets, eating poorly can cause bile stones. The more processed foods we eat the better our chances of getting them are. Losing weight too quickly can also cause gall stones. Low HDL levels can cause gall stones that can be caused by hormone imbalances especially high estrogen levels. Citrus fruits reduce gall stones especially the white part of the fruit. Rosemary has been shown to reduce gall stones. Pear juice has also been found to dissolve gall stones. Beet root, carrots and cucumber has been found to reduce gall stones. Drinking excess amounts of soda pop and consuming excess amount of processed sugar can cause gall stones and oxalate stones.

Excess vitamin C can cause oxalates but normal levels help dissolve oxalates. High meat consumption increases oxalates, excessive salt consumption can cause high oxalates, soda pop contains phosphoric acid which increases oxalates and causes kidney stones. Excess vitamin D intake can cause oxlates most do not recommend get more then 5000 IU of vitamin D and many say 60 IU is enough. High meat consumption can decrease citrate in the body, citrate prevents oxalates. If a person take magnesium citrate it should not be taken often because the body recycles citrate and it can build up in the body causing liver and kidney damage. If a person has metabolic issues that cause acidosis it can lead to oxalates, I post on addressing acidosis. DNA damage from oxidative stress or health issues can cause high uric acid levels which can increase oxalates. Omega 3 oils help reduce oxalates. Celery, carrots, pomegranate, watermelon, pumpkin seed oil. Helps reduce oxalates. Horsetail herb helped me a lot but has an alkaloid that can build up in the body so should not be taken more then three times a week. Citric acid not to be confused with vitamin C reduces oxalates this is why lemon is very good for reducing oxalates. Bear berry and uva ursa contain berberine which reduces oxalates and uric acid. Stinging nettles reduces oxalates and toxins that can cause oxalates. Stay hydrated but avoid water that has been chlorinated or fluorinated it is toxic an increases oxalates.

High Trymethylamines produced from our microbiome breaking down choline and carnetine is converted by Flavon Mono-Oxygenase 3 to Trymethylamine-N-Oxide. TMAO inhibits bile production. Olive oil has been found to prevent our gut microbiome from producing Trymethylamines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215539/

Crushed flax seed and oat haul increases bile flow.

If we do not correct the health issues causing our bile receptors to be inhbited it can lead to Non Alcohol Fatty Liver Disease.

https://gut.bmj.com/content/67/10/1881.long

Balancing the immune system

https://iamajuicer.wordpress.com/2018/07/15/autoimmunity-what-causes-it-and-things-that-may-correct-it/

Reducing oxalates.

https://iamajuicer.wordpress.com/2018/07/13/high-oxalates-also-know-as-oxalosis-or-hyperoxaluria/

Healing the gut is very important.

https://iamajuicer.wordpress.com/2018/12/01/things-that-can-go-wrong-in-the-gut-and-how-you-may-be-able-to-correct-them/

information on our gut microbiome.

https://iamajuicer.wordpress.com/2018/11/19/true-cause-of-illness-and-things-that-may-help/

Things that may help with infections.

https://iamajuicer.wordpress.com/2018/08/12/herbs-that-help-with-infection/

Things that can break down scare tissue in the body is autophagy which I have posted on and HSP70 which is another thing I have posted on. Serrapeptase has been shown to break down calcium deposits and aggregates in the body. It must be used with caution. High dosage can start breaking down tissue in the body but low dose will reduce inflammation and help the body heal.

https://iamajuicer.wordpress.com/2018/07/22/heat-shock-proteins-and-their-effects-our-our-health/

Inflammation and toxins is why so many are ill now days.

https://iamajuicer.wordpress.com/2018/11/19/true-cause-of-illness-and-things-that-may-help/

Things that can go wrong in the gut and how you may be able to correct them.

This is not medical advice I am posting this for educational and informational purposes.

Always remember homeostasis is the goal.

This is not finished but I need to work on other things and I figure this will give people a good foundation to research and build on.

If your gut becomes inflamed it will become leaky. You will stop absorbing nutrients. This can cause bile to become inhibited. If the gut is inflamed you can develop a burning pain. In more severe cases the pain will travel and a person will feel the burning pain under their right breast , it can even travel to the side below the arm pit. When it gets that severe they start developing a lot of food intolerance. So they are limited on what they can eat, also digestive enzymes can leak into the blood. From the digestive enzymes being in the blood and the body catabolizing the muscles they will also start to burn. This can also cause the calf muscles to hurt and feel heavy. When this occurs a person will need to keep snacking because when the gut is empty it will cause the inflammation to increase. They need to find foods they do not react to, so they can snack on them and always try to keep something in the gut.

Lipopolysaccharide (LPS) is usually used when referring to pathogens. Our commensal microbes produce LPS which our body uses to identify them. Normally they are not harmful to the body and some of the other commensal consume LPS keeping levels down. But a loss of those commensal or leaky gut can cause LPS to enter our blood streams which can lead to sepsis so it is very important to protect and maintain the health of our guts.

If we develop leaky gut and do not correct it toxins like mercury that can be in our food and usually will get excreted can now easily enter the blood stream and a person may develop high levels of mercury, cadmium or other toxins in the body.

If you have leaky gut oxalates that usually get excreted can enter the body. It is very important to heal the gut because oxalates are very damaging to the body. Calcium will bond with oxalates preventing them from being absorb and is why if a person is lactose intolerant they need to work on correcting it because milk with meals would help prevent that. Some calcium supplements are not good for you so if you decide to take that route make sure you do your research. Once oxalates build up in your body it prevents the gut from healing so it is very important to reduce oxalate levels. I have posted on reducing oxalates.

There are 2 components to the intestinal barrier. Intrinsic barrier and extrinsic barrier.

Intrinsic barrier is composed of the epithelial cells lining the digestive tube and tight junctions that tie them together.

Our gut bacteria maintain the health of our gut but damage to our gut can inhibit FUT2 production. Our gut microbiome cannot get established if we are deficient in FUT2. Lactobacillus Casei increases FUT2 production by inducing ERK/JNK. Inducing ERK/JNK stimulates FUT2. Nitric Oxide induces ERK/JNK, arginine rasises NO levels. Hypoxia induces ERK/JNK. Interleukin 10 inhibits FUT2 so a person may want to be cautious when taking probiotics that stimulate IL-10. Lactobacillus species of microbiotia stimulate IL-22 especially L Johnsii. IL-22 stimulates FUT2 secretion.

Extrinsic barrier consist of secretions and other other influences like microbes that influences the epithelial layer but are not physically part of the epithelium cells and maintain their barrier function.

Intrinsic Intestinal Barrier.

The gut is lined by sheets of epithelial cells that define the structure of the mucosa they are tied together by tight junctions, which paracellular spaces and thereby establishing the basic gastrointestinal barrier. Paracellular spaces are were nutrients are transported into the blood stream and toxins can be transported to the intestines for removal. Toxins and microbes that are able to breach this barrier have unimpeded access to the circulatory system. The tight junction layer and the mucus membrane for the most part prevents this from happening when healthy. Some cells in the epithelial are not effected by acid but others do not have the protection so count on the mucus membrane to protect them.

Extrinsic Barrier

Mucus that coats the entire epithelium. Hormones and cytokines that regulate the function of our digestive system and maintain digestive health. Our gut microbiome are a part of the extrinsic barrier. They reside in the mucus membrane.

Tight junctions encircle the epithelial cells and are an important part of the intrinsic layer. Their permeability is regulated by zonulin.

Tight junction controls the equilibrium between tolerance and immunity to non-self antigens. It is involved in macromolecular transport and tolerance and immune balance. If the tight junction layer becomes too porous a person may develop autoimmunity and their bodies immune system will turn on the body and start causing autoimmune disorders. A person will develop food allergies and food intolerances. The longer this goes without being addressed the more a persons health will decline. They will develop many metabolic, genetic and immune dysfunctions. Many things can damage this vaccines have been shown to raise B cell levels which causes the tight junction layer to become more porous. BT Toxins in GMOs have been shown to cause the body to react in a way that the tight junction layer becomes more porous. Many farm chemical cause it to become more porous especially glyphosate and glufonisate cause it to become more porous. Stress and trauma can also cause the tight junction layer to become more porous.

Zonulin is the only intercellular modulator of the tight junctions. If zonulin becomes over expressed the gut becomes more porous leading to leaky gut. It is involved in the transport of macromolecules and in balance between tolerance and immune response balance. If zonulin becomes deregulated it can cause inflammatory bowel, anemia, systematic inflammation, red sore areas on the skin known as Sweet’s syndrome that can eventually develop into blisters that eventually turn ulcerative which is known as Pyoderma Gangrenosum. They can develop swelling and sores in the mouth. The eyes can become red sore and inflamed. This condition is called sceritis it can lead to uveitis which effects the iris and can lead to blindness. Bones may thin and become brittle. Oxalates will develop causing stone formation this can also effect the liver. Not only can it cause endogenous oxalates to be produced but now oxalates consumed in our foods that are normally excreted can readily enter the body. Gall stones may form because bile production and pancreatic enzymes become inhibited and a person can develop chronic diarrhea, constipation or alternate between the two.

When the bile is inhibited it is called Primary Schlerosing Cholangitis. From food particles and toxins entering the blood stream a person could start having excessive blood clotting. A person will start developing nutrient deficiencies from being unable to absorb and break down nutrients properly. A person will eventually develop high histamines if this continues they may develop asthma, they can start developing sarcoidosis throughout the body. Mast Cells can start to degranulate leading to mastocytosis or mast cell activation syndrome. This effects our immune system as you will see below. It can lead to diabetes, heart disease and many other chronic illnesses. It can also lead to obesity or anorexia depending on how the person has been effected.

In order to restore zonulin levels to normal the genetic, metabolic, oxidative stress, changes in ph for example if you have developed acidosis or alkalosis it will have to be addressed along with infections that come along with our immune system being disabled. I have posted on most of those issues and correcting them. There are three isoforms of zonulin. ZO- 1 , ZO-2 and ZO-3.

When we get an infection it is a sign we are lacking a nutrient or gut microbe that protects us. The infection produces lipopolysaccharide (LPS) which stimulates zonulin making our guts more porous. Also antibiotics can kill the butyrate producing gut bacteria which makes our gut more porous. Butyrate keeps many things at homeostasis. We cannot restore normal zonulin levels if we do not replace the butyrate producing bacteria and feed them with fiber, oligosaccharides, galactosaccharides, and fructooligosaccharides. The lower the diversity of our gut microbes the higher our zonulin levels will be showing that our digestive system needs feedback from a variety of microbes to function properly.

The fun part of all of this is they will tell you all this in in your head until you are so ill it will take months or years to heal. In the mean time they will still continue to treat the symptoms instead of the cause. It is a common theme with allopathic medicine. I have seen this with naturopathic also but for the most part naturopaths treat the cause and not the symptoms.

Things that can reduce zonulin is meditating, if you have experienced trauma work very heard to move forward. It is difficult not to look back but constantly looking back causes stress and can increase zonulin. Anger increases zonulin so try to learn to deal with frustration and bad situations in a calm way , the calmer we are the lower our zonulin levels will be.

Replace the butyric acid producing bacteria I listed many microbes that produce it if you search my blog.

Inflammation and immune dis-regulation and can increase zonulin so the microbes that increase T regulatory cells and inflammation will reduce zonulin. If your immune system has been disabled then microbiome that stimulates IL-10 will help restore immune function.

High LPS levels will increase zonulin so we need the gut microbes that reduce LPS. Studies have shown the higher our guts diversity the less ZO-1 is express which prevents leaky gut and inflammation.

Under normal conditions things with gliadin , glutin and lactose will not effect a healthy gut but increase zonulin when the mucus membrane is damaged.

There are many molecules that interact with each other to maintain the Zonulin layer and the tight junction layer.

Occludin plays a role in tight junction maintainence and assembly which is regulated by phosporylation of serine, threonine, and tyrosine risidues. It is important for maintaining TJ stability and function. Loss of occludin can lead to leaky gut, inflammatory bowel, and hyperplasia most likely from the inflammation. Occludin also regulates cell survival or death through the intrinsic system. It is important in receiving and transmitting cell survival signals. Occludin has a strong inhibitory effect on cancer. Loss of Occludin leads to cell death.

If Phosphorylation of tyrosine, threonine and serine residues is inhibited it reduces occludins interaction with zonulin. Dephosphorylation of ser/thr residues and poor phosphorylation of tyr residues causes a reduction in occludins interaction with ZO-1 leading to it’s seperation from the junctional complex and TJ disruption. It also leads to excess ROS production which increases gut permeability. Inflammation reduces occludin levels. Endotoxins also reduce occludin. Another function of occludin is in modulating the TJ response to cytokines to protect and heal the tight junction. Occludin plays an active role in cellular location of caveolin-1. Caveolin-1 is required for cytokine induced TJ barrier changes, where it is required for TJ remodeling. So addressing endotoxins, high B cell or T cell levels and reducing inflammation is very important for preserving occludin. Many of our commensals that increase T regulatory cells balance our immune system which would restore proper T and B cell levels. Many of our commensal microbes reduce inflammation and reduce LPS (endotoxins). I have posted on my blog which of those accomplish these things. TNF-a is involved in caveiolinn-1 mediated internalization of occludin which increases occludin, alleviating cytokine induced gut permeability. This can be induced by TNF-a which is an inflammatory cytokine.

Mucous Membrane

The mucus membrane is thin in most inflammatory bowel diseases but is thick in Chron’s disease which I have not researched much on. Inflammtion usually causes the globin which are the mucin secreting cells to become depleted but for some reason this does not happen in Chron’s disease.

All these genes listed below are negatively effected by leaky gut. It is very important to reduce inflammation and work on getting the gut healed to restore the mucous membrane. Damage to the digestive system and mucus membrane causes many genes to become dis-regulated. MUC2 gene is the major gene responsible for the secretion of gel-forming mucin in the intestinal tract. It coats the endothelial surface protecting it from inflammation,chemicals, damage and infection. There are 20 MUC genes. There are many mucin categories that are enriched with proline, serine, and threonine. They are modified by o-glycosylation that creates oligosaccharides that confer on mucins their individual functions. Mucin is made mostly of fat. Those with inflammatory bowel and ulcerative colitis have low B-oxidation which is needed for the break down and use of fats. Since the mucous membrane is mostly fat this causes it to become dysfunctional. This makes people sensitive to fats and is why it is best if they consume medium chain fatty acids because the body can readily use them. Eggs yolks are a good source of phosphatidylcholine which is what the mucus membrane is mostly made of. Most with inflammatory bowel or colitis are sensitive to lecithin. I used sun flower seed lecithin and I did not react to it and it helped me a lot with my healing. Most other sources of lecithin I had to avoid. There are many studies showing that using sun flower seed as a source of lecithin has been shown to heal the gut. As for Chron’s disease I have a theory I have not had a chance to research but I believe they may be deficient in commensal microbes that digest sialic acid. Many of our commensals need it to thrive. Bacteroides Fragilis, Bacteroides Thetaiotaomicron, Bifidobacterium Bifido, Bifidobacterium Longhum, Bifidobacterium Infantis, Akkermansia Muciniphila all need sialic acid to thrive. Another theory I have about Chron’s that I have not gotten to research is they may have an overgrowth of those and that inflammation or LPS is stimulating the production of excessive sialic acid causing and overgrowth of those microbes.

Phospholipase A2 activity is higher in those with inflammatory bowel and colitis.

If a person is having trouble with methyl donors they will not produce enough phosphatidylcholine because methyl groups are used in the process of producing phosphatidylcholine for the mucous membrane. So combine that with the low B-oxidation and you see why it can be so difficult to heal. Disulfide bridges are also a component of phosphatidylcholine showing the importance of addressing things that can impair sulfation.

Phospholipase A2 is high in those with inflammatory bowel and colitis. Phospholipase is stimulated by inflammation. It is a mixture between inflammation and substance P and is why those with leaky gut have high substance P levels. When substance P levels get high the skin will have a burning sensation especially in the scalp and it may go down the spine. Substance P levels increase at night so the symptoms will worsen at night.

Annexin also known as lipocortin keeps PLA2 in check. Adrenal hormones increase Annexin but in many people with inflammatory bowel the adrenals become depleted from being over activated and they develop Addison’s disease which is a deficiency of adrenal hormones. Adaptogens help alleviate this which would help restore annexin levels. Annexin also helps repair our immune system. If annexin gets low the blood brain barrier becomes porous because it helps maintain the blood brain barrier. Annexin is also involved in protecting the brain from infection. It is very important to support the adrenals with the proper nutrients and to reduce inflammation so the adrenals can recover. Oddly Okadaic Acid a toxin found in shell fish increases annexin. This is something a person would definitely need an experienced medical professional to do. IL-6 increases annexin expression. To restore normal cortisol levels stress management is very important. Increased stress depletes cortisol. Getting rest is important, even if you cannot sleep just laying and resting can help increase cortisol. Avoid, caffeine, alcohol and smoking. Our mucosal layer will take up fats and integrate them to strengthen itself. Omega 3 oils, cod liver oil, nuts, and avocados help increase cortisol. Avoid processed sugar it depletes cortisol levels. Citrus fruits especially grape fruit increases cortisol but grape fruit inhibits certain cytochrome P450 enzymes so should not be eaten too often. Eat foods high in melatonin or take melatonin supplements at night which will increase cortisol. Non processed carbohydrates help increase melatonin. Magnesium is important for maintaining proper cortisol levels. Reducing inflammation can help normalize cortisol levels. Earth grounding and getting sunlight help to normalize cortisol levels. I still laugh when I mention earth grounding because I thought how could something so simple have so many health benefits. So I was determined to find research to show those earth grounders were crazy instead it was I who was crazy and the earth grounders are correct. I could find no research to prove them wrong but plenty of research showing the many health benefits of earth grounding.

We have to keep in mind goblet cells build our mucus membrane and when inhibited by inflammation, toxins or even damage to our digestive system our ability to produce mucin is reduced or inhibited. Bismuth even though it is a metal, is for the most part none toxic it takes very high doses for a very long time to reach toxic levels. It helps the gut heal. It kills many pathogens and can cause commensals that have turned pathogenic to go back to commensal. Mucilage helps protect the gut so it can heal. I have posted on reducing inflammation if you search my blog. Oatmeal is high in mucilage but you must get organic because they use glyphosate and glufonisate on grains and beans to dry them and those destroy our gut and kill our gut microbes. Three very good sources of mucilage is okra, arrow root and oatmeal. Make sure the oatmeal is organic. Most non organic oatmeal has farm chemicals that destroy the gut.

Here is an in depth article on mucus membranes.

https://www.readkong.com/page/the-interaction-of-the-gut-microbiota-with-the-mucus-1350713?p=1

Sialylation has been found to be increased in those with inflammatory bowel dieseases. Excessive sialylation increases inflammation. IL-10 inhibits Sialylation. Their are probiotics that increase IL-10 but IL-10 inhibits FUT2. So an oligosaccharide,galactosaccharride and fructosaccharide would probably have to be supplemented with it. I suspect the body is trying to increase the commensals that rely on the nutrients produced by sialylation and they have been depleted by antibiotics. Some commensals rely on FUT2 but others rely on sialylatin. Some do not produce the enzymes to break down sialic acid and rely on other commensals to produce it. A deficiency in either of them is probably what is causing the high sialylation. The body is trying to feed them. It is not getting the feedback from those commensals.

The bacteria this would help thrive are B Fragilis, B Theaiotaomicron, B Bifidum, B Longhum, B Infantis and A Muciniphila. I believe those with inflammatory bowel especially those with Chron’s will be deficient in those because those with Chron’s have a thicker mucous membrane.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747158/

The increased inflammation and infection caused by the above mentioned things results in an accumulation of ROS which can lead to further damage and it disturbs mitochondria function and autophagy. Once the mucus membrane has been damaged all the things mentioned below lose their protection and become dysfunctional. It may be necessary to take mucilage and bismuth to help protect them and restore their function. Once the mucus membrane breaks down it creates a cycle that has to be broken because the mucus membrane needs the things mentioned below to function properly and they need the mucus membrane to protect them and to function properly. Dysfunction in either of them from infection or toxins can start a cycle that has to be broken to heal. Our gut microbiome cannot become established without the mucus membrane because it also protects them. Our mucus membrane is a mediator between host and microbiota interactions. Decreased mucus membrane thickness causes a change in our gut microbiome and makes us more prone to infections.

This is where addressing sulfation issues, methyl group issues and issues with thiols comes in because the production of mucin requires all of those to be functioning. I have posted previously on how to deal with those issues. For the production of the oligosaccharides the endoplasmic reticulum and stem cell are required.

L-cysteine, L-arganine, L-threonine, L-serine, and L-cysteine increase mucin production in the digestive system and have been shown to promote gut microbiome homeostasis. Citrus fiber increases mucin especially the white part of the fruit. Pectin stimulates Goblet cell formation which secretes mucin. The microbiome that help restore gut health are Bifidobacterium Bifido, Bifidobacterium Breve, Bifidobacterium Lactis, Enterococcus Faecium, Lactobacillus Acidophilus, Lactococcus Lactis

For those who do not have glutamate issues bone broth heals the gut very quickly. Those who have high levels of sulfur digesting bacteria will have problems with the consumption of bone broth also.

The small intestine is the portal for the absorption of most nutrients in the body. The chyme which is the digested food that has exited the stomach enters the small intestine pancreatic enzymes and bile is secreted. This breaks the food down and if functioning properly it will be almost liquid when it enters the lower intestinal tract. Bicarbonate is also added by the body to reduce the acidity before it enters the large intestine. The enteric nervous system and gastrointestinal hormones regulate this process and the intestinal motility. Intestinal dysbiosis can cause incorrect communication or inhibited communication which leads to inflammation, intestinal damage and it could lead to a loss of the ability to produce bile and digestive enzymes. To restore proper function we must reduce the microbe causing the problem. Those who have high sulfur digesting bacteria will develop high hydrogen sulfide levels which interferes with sulfation and can interfere with the proper function of the CBS and BH4 pathways. This can lead to high sulfide levels in the body. BH4 levels will become low causing ammonia to build up when protein is consumed. The high ammonia levels will cause some commensals to go into protection mode and they will become pathogenic. Candida and H Pylori are two examples. To make matters worse they also start producing ammonia to protect themselves from the acidic environment. The digestive tract is supposed to be acidic. Ammonia alkalizes it this also makes us more prone to infections because the commensal microbes that protect us cannot survive in an alkaline environment. When we lose our commensal bacteria we lose proper immune function and our zonulin levels increase and our gut becomes more porous leaving things enter the blood stream that could not normally enter. Inflammation and oxalates can inhibit bile flow causing it to back up, when this happens the gallbladder is effected. Instead of addressing the problem modern medicine gets rid of the symptom by removing the gallbladder thus the illness continues to worsen and taking the gallbadder out can contribute to it’s progression.

If bile becomes inhibited it inhibits the vitamin D receptor further inhibiting bile production and adding to the problem because cholesterol production and conversion becomes inhibited. This will make bile become sludgy leading to low bile flow which will increase estrogen levels and cause high unbound copper levels in the blood. Bitter herbs increase bile flow but the vitamin D receptor has to be addressed along with balancing the microbiome in the gut and healing the intestinal tract.

This is why I often times recommend grape seed extract and bacopa to people. It prevents thrombosis. Inflammation because endotoxins can cause thrombosis. Grape seed extract and bacopa reduce inflammation and prevent thrombosis. If thrombosis occurs in the portal vein it will effect the liver, pancrease, and digestive system. This causes pain in the stomach, bloating, inflammation, pancreatic pain, pain in the gallbladder. This can lead to death. Bile flow will become inhibited speeding up the progression of portal vein thrombosis. Those with hepatitis need to use hawthorne or something else. Resveratrol activates hepatitis.

portal vein thrombosis

gastrointestinal symptoms (ex: abdominal pain, nausea, vomiting, and diarrhea), fever and constitutional symptoms (ex: fatigue, malaise, and anorexia/weight loss) [3]. We can also find hepatomegaly with elevated liver enzymes and jaundice [3], when associated with liver abscess or cholangitis [2]. Laboratory tests usually demonstrate elevated markers of inflammation [2]

https://www.journalmc.org/index.php/JMC/article/view/3050/2378

If not addressed in time it can lead to portal hypertension. This results in brain swelling, abdominal swelling . Confusion, anemia and low white blood cell count.

https://my.clevelandclinic.org/health/diseases/4912-portal-hypertension

Autophagy is very important in maintaining health and we need a proper balance. It can be disrupted if we have intestinal damage. If autophagy is inhibited we become prone to infection and mitochondrial dysfunction. Autophagy is the housekeeper of our cells. One common theme you will see is inflammation and shows the importance of reducing inflammation. Which could involve diet changes, addressing metabolic issues, reducing toxins and infections. Addressing detox issues and detoxing in an appropriate manor for the individual. Addressing gene issues which could be caused by any number of things including a lack of the microbe in the gut that may modulate that genes function.

The mucus membrane in our digestive system protects us from infection, physical and chemical harm. Our commensal bacteria cannot exist without it. It is very important to restore our mucus membrane when damaged in order to restore intestinal homeostasis. Many genes mentioned below are effected when it is damaged because it causes a dysfunction in them. Autophagy is very important for the maintenance or proper gene function.

Paneth cells are located within our mucus membranes and provide immunity, prevent damage to the digestive system and is involved with nutrient absorption. Loss of our mucus membrane from loss of microbiotia, drugs or farm chemicals found in our food can destroy our mucus membrane. This causes damage to the digestive system which can further inhibit the bodies ability to produce mucin. This makes us more susceptible to infection. Paneth cells stimulate the production of AMPs which fight infection and modulate commensal microbiome and innate immunity. A list of AMPs are defensin-like human lyzosome, defensin (HD)-5 and 6, lyzosome, regenerating islet derived gamma(Reg3y), and phospholipase A2 group 2A(sPLA2) as well as inflammatory cytokines such as Transforming Tumor Necrosis Factor A (TNF-a), Growth Factor B1 (TGF-B1), and Postaglandin E2. AMPs are sensitive to ER stress which I discuss below.

Autophagy protects against infection by producing Antimicrobial Peptides and degrading organelles that break down misfolded proteins and AMPs break down pathogens. This can ease the over activated inflammatory response and over active immune response. Some AMPs are defensin and cathelicidens which protect against microbes.

Intestinal Epithelial Cells. (IECs) – form a physical and chemical barrier involved in inflammatory response and immune reaction. IECs work as an interface between the quantitive microbial ecosystem in the intestinal lumen. Lumen is inside space or opening in a tubular structure.

There are 6 types of IECs

Goblet Cells which secrete mucin to build up the mucin barrier.

Enteroendocrine cells which produce gastrointestinal hormones that communicate with the nervous system, the brain and organs throughout the body. They respond to nutrients within the intestines. Helps restore intestinal tissue.

Absorptive Enterocytes – epithelial cells in small intestine. They are involved in nutrient absorption, absorption of conjugated bile acid, lipid uptake, Issues with Absorptive Enerocytes can inhibit glucose absorption and can result in lactose intolerance and many other food intolerances. It can also result in an electrolyte imbalance. Enterocytes secrete a series of chemokines and cytokines which regulate immune responses of subjugant mucosal. (Mucosal control)

Tuft Cells – brush cells which are chemosensory cells in the intestinal epithelial lining. Tuft refers to microvilli projecting from the cells. They increase during parasite infection. They are the sole source of Interleuken 25 which induces NF-kB activation which helps protect from infection. High levels of IL-25 raises eosinophils which causes inflammation and is suspected of causing inflammatory bowel diseases. Eosinophils have been shown to kill many types of cancer cells. Infection also stimulates Tuft Cell to produce IL-25. They are increased through a T cell response through a type of lymphatic tissue. Tuft cell also secret endogenous opioids. Eosinophils cause asthma, cardiovascular disease and can even cause headaches, mood swings and brain fog.

Microfold Villous Cells – are found in the Gut-associated Lymphoid Tissue (GALT) of the Peyers Patches in the small intestine and the Mucus-associated Lymphoid Tissue (MALT). M Cells initiates mucosal immunity. They allow the transport of microbes and across the epithelial cell layer. From the gut lumen to the lamina propria. M cells contain Epidermal growth factor which acts as a sensor to stimulate repair through the intestines including the mucus membrane , tight junction protein layer and it stimulates goblet cell differentiation and many other things in the colon.

Endoplasmic Reticulum are organelles within our cells and plays a major role in the production of proteins and lipids. So this is where our enzymes , hormones and even our detox enzymes are produced.

Endoplasmic Reticulum Stress Unfolded Protein Response (UPR) is activated in response to unfolded or misfolded proteins in the endoplasmic reticulum. It stops the production of unfolded or misfolded proteins it is the quality control mechanism. It will stop production and start cleaning the bad proteins out. If it continues for too long then it will induce apoptosis which is cell death. If overactivated which vaccines and many farm chemicals can cause to happen it can lead to prion disease. It plays a valuable role in intestinal endoplasmic reticulum survival and function. Dysfunction of endoplasmic reticulum can result from genes that have been effected from infection, toxins, or even stress can result in abnormal UPR function. This is referred to as Endoplasmic reticulum stress.

ER stress activates three kinds of proteins which reside in the ER membrane to detect UPR in ER Lumen and resolve them. Autophagy reduces ER stress.

inositol-rquiring membrane kinase endonuclease1 (IRE1) via a really long pathway that I am certain you do not want me to type out. Issues with the genes involved in these mediators in intestinal endothelial cells will change the histological structure of the intestinal epithelium.

XBP1- inhibition will exhibit impaired Paneth Cells, which leads to dysbiosis and spontaneous intestinal inflammation which may induce activation of NF-kB pathway which can lead to inflammation, anxiety, chronic depression, insulin and leptin resistance, it increases risk of cardiovascular disease and high TH17 levels which can lead to psoriasis or lupus, Many who have intersitial cystitis have high TH17 levels. It can cause bone lose and Alzheimers. On the other end of the scale not enough NF-kB can produce many health problems. Like lower cognitive function, inhibited ability to heal, inhibited nerve growth and brain plasticity. This is a good article covering it in more detail. https://www.selfhacked.com/blog/nuclear-factor-kappa-b/

The second gene that can increase risk of inflammatory bowel disease is oromucoid-like3 (ORMDL3). Over expression can lead to immune/inflammatory diseases. It has been linked to childhood asthma. Over expression causes inhibited calcium buffering capacity of the mitochondria. This can disrupt endocytosis, enzyme control , cell growth and proliferation and cell apoptosis. ORMDL3 takes part in protein folding and in regulating UPR. It is believed ERs induced inflammation in paneth cells may disturb ORMDL3 levels leading to inflammation.

TREM1 (Triggering Receptor Expressed On Myeloid Cells-1) inhibits autophagy and increases ERs stress levels. This has been shown to increase the severity of inflammatory bowel diseases. Defective autophagy in the endoplasmic reticulum can predispose someone to inflammatory bowel diseases form a decreased clearance of IRE1 during ERs. High IRE1 levels impairs insulin signaling this can lead to many metabolic diseases. TREM1 can either increase inflammation or decrease it. During infection TREM1 increases inflammation. TREM1 also interacts with other inflammatory pathways which can also result in TREM1 increasing inflammation. TREM1 is high during septic shock. Sustained increased levels of TREM1 can lead to inflammatory bowel disease, cardiovascular disease and atherosclerosis. TREM1 is needed to help clear infection. Unfortunately when an infection that contains OspA protein that are difficult for the body to clear like HIV and Borellia (Lyme Disease) it can cause TREM1 levels to remain high. This is why it is very important to work on reducing inflammation and address infection. Most infectious diseases there are no test for and the test they do have has a high failure rate at detecting the microbe responsible for the illness. But the body and what genes are effected and cytokines present can indicate when there is an infectious agent present. The more difficult infections can be killed but it takes a multilevel approach because most that carry the OspA take multiple forms and have to be addressed differently for each form it has taken.

Inflammatory bowel disease have been shown to have a dis-regulation of T Cell which can be induced by toxins, drugs, vaccine injury, farm chemical or processed foods.

Autophagy is a conserved lysosome-dependent catabolic process involved in degrading and recycling aggregates as well as damaged organelles. Enhancement of autophagy promotes the survival of various cells including intestinal endothelial cells, and nuetrophils by protecting them from microbial toxins. A disturbance in autophagy could disturb the function of intestinal endothelial cells and influence inflammatory response, immune response, ROS levels and endoplasmic reticulum stress. This can lead to inflammatory bowel diseases. Autophagy plays a vital role in alleviating of intestinal inflammtion, degredation of damage associated molecular patterns (DAMPS), which can help prevent inflammatory bowel diseases. PAMPs refer to various kinds of endogenous materials produced by stress, impaired or dying cells covering DNA, RNA, ATP, histones, hyaluronan, uric acid, heparin sulfate, the S100A calgranulins, IL-1, HSP, and chromatin-associated high motility box1(HMGB1).

Basal autopaghy occurs in nearly every cell to maintain homeostasis of the ammino acid pools. There are three types of autophagy.

Macropahy – targets material such as cytoplasmic components or invasive bactria which are surrounded by a double-membrane bound autophagosome.

Autophagosome when combined with lysosomechanges into a single-layer membrane autolysome with a strong degradative and digestive ability.

Microautophagy – during the process of microautophagy lysosomal/vacuolar membranes invaginate (fold in on itself) to engulf intracellular components via a non-selective degradative mechanism.

Chaperone-mediated autophagy transports organelles and proteins into lysosomes only with the assistance of chaperones which are located in lysosomal lumen. Chaperons are proteins that assist in convalent folding or unfolding and the assembly or disassembly of other macromolecular structures. They assist in the assembly of nucleosomes which are basic units of DNA.

Two steps of Autophagy.

The first step of autophagy cup-shaped double membrane phagophores are shaped in the cytoplasma of the cell, and then misfolded proteins, damaged organelles or bacteria are engulfed to become sperical double membraned autophagosomes. Autophagosomes are usually considered to be produced from the nucleation and membrane expansion of phagophores.

During the second step autophgosomes fuse with lysosomes and endosomes to form a single-lipid layer autolysome, which is regard as basal units for degradation and digestion. Autophagy process is induced by the detection of various specific cues such as starvation or invasion by pathogens.

Two proteins are known to participate in autophagy which include Mammaian Target of Rapamycin (mTOR) as an inhibitor and adenosine monophosphate activated protein kinase as an indicator. mTOR is often activated by lower levels of Adenosine Triphosphate (ATP) caused by nutrient sufficiency or several growth factor stimulations. mTORC1 inhibits autophagy in the presence of nutrients. mTORC1 regulates glycolysis, lipid biosynthesis, and the pentose phosphate pathway has been found to be under the control of mTORC1. mTORC1 mediates upregulation of SREBP-1 activity which is necessary for lipid biogenesis. mTORC1 increases mitochondrial DNA copy number and as well as encoding many genes involved in oxidative metablolism. It has been found that mTORC1 promotes transcriptional activity of PPARy coactivator (PCG-1a) which is usually low in those who have inflammatory bowel diseases. This leads to the inability to break down fats and cholesterol causing many health problems because lipids are needed by almost all cells of the body especially the digestive system to maintain proper function and health. Ironically mTORC1 inhibition leads to longer lifespan. mTORC1 inhibits autophagy. mTORC1 increases NRF2 activity the master regulator of the antioxidant system.

Excess mTORC1 activation can cause endoplasmic reticulum stress and excess ROS production.

Low ATP levels inhibits mTORC1. Inhibiting mTORC1 increases glucose uptake. Hypoxia (oxygen deprivation) inhibit mTORC1. Amino Acid deprivation can inhibit the citric acid cycle (TCA cycle) this also inhibits mTORC1. The body inhibits mTORC1 when it senses DNA damage. Autophagy reactivates mTORC1 whose activity then promotes the replacement of lysosomes consumed during autophagy.

Symptoms of excess mTORC1 . Since there is no information on what excess mTORC1 does I will have list the symptoms of inhibited autophagy and high ROS levels since those are issues caused by high mTORC1 levels.

Symptoms of inhibited autophagy. Nuerological problem , inhibited autophagy can lead to inflammation in the brain, mental illness. Mitochondrial dysfunction, decreased antioxidant function which can lead to high levels of ROS. Pancreatic inflammation. Fat accumulation throughout the body and can lead to fatty liver disease. Issues with lysosomal storage, diabetes and sickle cell anemia. Frequent illness from infectious agents.

Symptoms of high ROS. ROS is needed for redox signaling but becomes damaging if levels get too high. High levels of ROS cause inflammation. Leaky gut and can cause a leaky blood brain barrier. This also can lead to nuerological damage and brain inflammation causing mental illness. Can cause liver damage resulting in a hepatic liver. Fatigue from reduced energy levels. Mitochondrial dysfunction which can lead to MS. Here is a link to a good article on oxidative stress.

https://www.selfhacked.com/blog/oxidative-stress-101/

Things that stimulate mTORC1. Resistance training, amino acid L-Luecine, Beta Hydroxy Beta-methylbutyric acid which is a precursor of butyric acid. High intake of Iron stimulates mTORC1.

Inhibitors of mTORC1 are green tea, resveratrol, curcumin, caffeine and alcohol. Iron deficiency inhibits mTORC1. Green tea can damage the liver if taken for too long and curcumin chelates iron so can make a person anemic if consumed too long.

VDR

Vitamin D receptor (VDR) mediates the activities of vitamin D3 which is the activated form of vitamin D. A deficiency can effect our digestive system in many ways. The VDR is involved in regulating 33% of the genes in the body so problems with it can effect many things. VDR and Retinoid X receptor interact to with each other and can activate each other so issues with either one can effect vitamin D homeostasis. Inhibited VDR effects calcium homeostasis, electrolyte balance, and blood pressure.

Vitamin D3 acts as a hormone a hormone and helps regulate innate and adaptive immune responses. Those with low vitamin D levels or inhibited VDR receptor are prone to infection with Mycoplasma Tuberculosis. VDR is involved in producing the antimicrobial peptide/IL-37, defensin beta B, CLDN2 encoding claudin 2 and ATG16L1 related autophagy which protects us from inefection.

The VDR receptor is involved in gut microbiome balance and autophagy. Autophagy is the house keeper of our cells it helps clean them out, protect them from infection and helps to prevent misfolded proteins. Inhibited vitamin D receptor can cause inhibited bile flow and a decrease in LDL and increase in HDL. The reduced LDL causes bile to become sludgy which leads to biliary issues and gallbladder problems and can result in gall stones and biliary blockage.

When the VDR receptor is inhibited or there is a vitamin D deficiency we can develop inflammatory bowel diseases. IKBa is an inhibitor of pro-inflammatory NF-kB.

VDR inhibition or vitamin D deficiency alters the composition of intestinal microbiome. Butyrate producing bacteria become less numerous. Butyrate increases expression of VDR so a deficiency in Butyrate would further add to the inhibition of the VDR receptor. Butyrate also suppresses intestinal inflammation and enhances AMPs. AMPs help protect us from infection.

Toxins, mold toxins, infection and a lack of nutrients can inhibit the vitamin D receptor. High levels of vitamin D3 indicates the body has recognized an infection and is trying to fight it.

Farm chemicals especially glyphosate and glufonisate inhibit the vitamin D receptor. Many toxins found in processed food can also inhibit the vitamin D receptor.

Symptoms of inhibited VDR.

If the VDR is inhibited a person may experience problems with methyl donors and low dopamine levels. They may experience frequent infections and be low in GcMAF. Inhibited VDR can cause bone loss, hair loss, brain fog, increased TH17 levels resulting in lupus, psoriasis and/or skin rashes, tooth decay and poor oral health, inflammation throughout the body, can lead to high blood pressure. Low LDL which inhibits bile production resulting in biliary and gall bladder problems and can lead to stone formation. Electrolyte imbalance and iron deficiency. Low dopamine and GABA levels is a result of VDR inhibition. Prolactin level become low when VDR is inhibited. Gut dysbiosis and inflammation in the digestive system. Increased creatine and albumin levels and decreased alkaline phosphatase are symptoms of low vitamin D or inhibited vitamin D receptor. VDR inhibition or vitamin D deficiency can result in mast sell activation syndrome. CYP3a4 an enzyme needed for detoxing xenobiotics and drugs becomes inhibited. Hormonal imbalance is also a result of VDR inhibition. Hashimoto’s syndrome can result from VDR inhibition. Heart disease can be a result of VDR receptor inhibition or vitamin D deficiency. In more severe cases VDR inhibition can lead to liver and kidney disease.

Symptoms of Vitamin D deficiency.

Joint stiffness or pain, back aches, tooth decay, bleeding gums or gum disease, muscle cramps, hair loss, bone loss, weakening of bones, increases risk for cancer, sleep apnea, brain fog, fatigue, depression, leaky gut, excess sweating especially in the head area.

Excess vitamin D can lead to many health problems and can result in loss of bone from a disruption in the mechanisms that control calcium homeostasis. Though it is needed for calcium absorption high doses can have the opposite effects. High levels of vitamin D can lead to oxalate formation. Many studies show anything over 5000 IU a day can lead to oxalate formation and many health problems.The recommended daily allowance of vitamin D is 600 IU. It is best to get vitamin D from food sources. Exposure to sunlight, far infrared, halogen lights can increase the bodies production of vitamin D. Short term raised levels have been found to be beneficial but long term raised vitamin D levels have been found to be harmful to our health. High levels of vitamin D can contribute to the inhibition of the VDR. Excess vitamin D can result in high levels of calcium in the blood resulting in calcium deposits forming in the organs including the lungs.

Sources of vitamin D. Sunlight, halogen lights, far infrared light increases the bodies production of vitamin D. Excess sunlight has been shown to cause high levels of vitamin D and is why life guards have some of the highest rates of kidney stones. Fish oil contains vitamin D. Sardine , salmon and cod liver oil are good sources. I try to make sure the fish is not from contaminated areas. Most sea food is high in vitamin D. Mushrooms and eggs are a good source of vitamin D. Animal liver is another good source of vitamin D. Cestrum Diurnum, Waxy leaf nightshade (solanum glaucophyllum), yellow oat grass (trisetum flavescens) are plant sources of vitamin D. Those plants are so high in vitamin C that they cause calcinosis in grazing animals. Brown and read seaweed are also sources of vitamin D and cholesterol. Mercury found in fish is for the most part only a problem if we have leaky gut. When the gut is intact only about 5% of the toxins like mercury get absorbed that have been consumed and when healthy the body can easily detox that amount unless it is shot directly into the blood stream. I mention this because even though they claim vaccines do not contain mercury some still do.

Things needed for the body to be able to use vitamin D. Vitamin K2, Vitamin A, zinc, sulfur is needed to sulfate vitamin D so sulfation issues need to be addressed. Magnesium increases the bodies response to vitamin D. Boron increases vitamin D in the blood stream. Water is needed, dehydration inhibits many receptors in the body. Silica helps improve the function of many receptors in the body. Sunlight helps to sulfate nutrients. DAO and lysine are also needed to sulfate vitamin D. Boron is touchy, low levels reduce estrogen high levels increases estrogen.

Things that enhance vitamin D receptor activity. Parathyroid hormone, Sirt 1, Dopamine, Omega 3 , Omega 6, Phytoestrogens, Testosterone, Postaglandulins and bile activates VDR. Bitter herbs stimulate bile production. Even if you do not swallow bitter herbs just tasting them stimulates bile production. Resveratrol activates the vitamin D receptor. Querciten enhances vitamin D receptor activity. Curcumin stimulates the vitamin D receptor but if taken for too long it can lead to anemia because it chelates iron from the body. So one may use it at first to help stimulate the VDR receptor but probably should just take maintenance doses to make sure it continues to function. Human Growth Hormone stimulates the vitamin D receptor. Sleep, fasting, and strength training increase HGH.

Things that can inhibit VDR are cortisol/glucocorticoids, high prolactin levels, imbalance in thyroid hormones, TGF-Beta, phosphatonins which regulate phosphate homeostasis, and ubiquitin can inhibit VDR. Many of these things are inhbited by autophagy which would prevent them from inhibiting the VDR receptor. Caffeine can also inhibit the VDR. High TGF-B levels can be an indication of T cell imbalance and/or B cell imblance. Probiotics that reduce inflammatin and increase T regulatory cells should reduce TGF-B. High phosphatonins is a sign of low klotho levels. Exercise increases klotho, Most Acidophilus bacteria and Lactobacillus Lactis increases klotho. Cordyceps mushrooms increase kltoho. PPAR Gamma activators stimulate klothos, Some PPAR gamma activators are berberine, magnolia, and Omega 3s. Those who are obese should not stimulate PPAR gamma because they are usually PPAR gamma dominant. Adaptogenic herbs like suma root and maca root can help normalize adrenal levels. Ubiquitin levels are reduced by autophagy. High prolactin levels can result from toxins in plastic containers used to store food and some farm chemicals found in our food supply. There are also chemicals in processed foods that can cause high prolactin levels. Those who are taking drugs should not use berberine or things that contain it because it inhibits the cytochrome P450 enzymes needed to detox medications.

Fulvic acid and nobiline induce autophagy. We do not want to overstimulate autophagy. Fasting also stimulates autophagy but those who are Type1 diabetics have to be careful fasting can induce ketoacidosis in them. Branch Chain fatty acids can inhibit autophagy. Tumeric, ginger, berberine, gensing, mushrooms and elderberries can stimulate autophagy.

NOD2 – Nucleotidebinding Oligomerization Domaincontaining Protein 2 whew that was a lot. A member of the NLP family which is a group of immune regulating proteins. It is a sensor of muramyl dipeptide which is a constituent of both gram negative and gram positive bacteria. It is found in macropages and paneth cells. When inhibited a-defensin numbers are decreased, lower sensitivity to bacteria infection, and altered immune function from Toll Like Receptors becoming suppressed. This results in the inability to clear bacteria infections from the intestines. Inate and adaptive immunity is impaired. Nod2 induces autophagy through the NOD2 pathway. NOD2 is induced by NLP or bacteria infection, this promotes the delivery of NOD2 which enhances inflammation. Showing that if You have high NOD2 levels you would not want to induce autophagy. NOD2 prevents infection in cells which is mediated by ROS and MAPK pathways. NOD2 altered expression can lead to inflammatory bowel disease. Many cellular proteins interact with NOD2 directly and regulate it’s function positively or negatively. Among these proteins is Erbin. Erbin regulates Erbb2 if Erbin is inhibited Erbb2 levels can go up resulting in cancer growth. Centaurin B1 which I have no idea what it’s function is. Angio-associated migratory protein which is involved in endothelial tube formation and endothelial cell migration. It is involved in angiogenesis. Carbamoyl-phosphate synthase 2 is involved in the production of nucelotides in cells. Mitogen-activated protein 1 which helps down regulate NOD2. Heat shock protein 90 interacts with NOD2. HSP90 is involved in folding , intracellular transport and the degradation and maintenance of proteins. I have post on heat shock proteins like HSP90 and HSP70.

NOD deficiency. NOD2 is involved in maintaining balance between the microbiome and immune response. NOD2 deficiency results in loss of epithelium integrity, and increased susceptibility to intestinal inflammation. NOD2 deficiency can cause dysfunction in intestinal paneth and goblet cells. Deficiency increases IFN-y, and decrease ROS production which protects from infection so we need a balance because excess ROS can damage tissues in the body.

NOD2 upregulation. Vitamin D supplementation has been shown to increase NOD2 which helps to fight infection. Excess NOD2 can lead to rheumatoid arthritis, and systematic inflammation. Excess NOD2 has been linked to cardiovascular disease and pulmonary disease. NOD2 prevents inflammation in the eyes.

NOD2 deficiency causes low TH17 levels, inhibited immunity, and will be more prone to cancer. NOD2 is also involved in the detection and eradication of viruses.

Excess NOD2 causes systematic inflammation and sarcoidosis. Often times it is mistaken for cancer or copd. High NOD2 levels is a sign of infection.

Damage to the mucus membrane and intestinal tissue can cause it’s dis-regulation. This shows the importance of restoring mucus membrane and work on healing the gut.

Atg16L1

Autophagy-Related Protein 16-like Protein 1 – Deficiency in Atg16L1 impairs recruitment of Atg12-Atg-5 complex which impairs the engulfment of pathogens and cellular organelles during the process of autophagic catabolism. Atg16L1 defeciency cause Paneth cell dysfunction and increases inflammation. Atg16L1 causes high leptin and adiponectin levels. A deficiency in Atg16L1 leads to intestinal lesions. Leptin tells the brain we do not need to eat. Leptin increases inflammation in the body. High leptin levels lead to chronic fatigue. Leptin can cause Th1 dominance. Those with high IL-10 levels would want to avoid probiotics that increase IL-10 because leptin increases IL-10. Leptin causes mast cells to become more inflammatory. Leptin causes lower T regulatory cells which keep our immune system at homeostasis. Leptin can cause excess blood clotting (throbosis). Leptin can cause high blood pressure. Leptin increases estrogen levels. Adiponectin is a protein hormone involved in glucose levels and fatty acid breakdown. High adiponectin levels causes a loss of appetite it causes weight loss and works synergistically with leptin. Adiponecton decreases gluconeogenesis. It increases B-oxidation of fats. It protects against endothelial dysfunction. It increases insulin sensitivity. So you can see the importance of Atg16L1 homeostasis.

Mir223 restores autophagy and Atg16L1 homeostasis. Mir233 downregulates inflammation. Mir233 is reduced in sepsis. Mir233 increase HDL cholesterol levels. But Mir233 is upregulated in inflammatory bowel diseases. Increasing Claudin-8 inhibits Mir233 inflammatory effects.

ROS (Reactive Oxygen Species)

ROS or Reactive Oxygen Species modulates cellular function under normal conditions. ROS is produced during the process of oxidative phosphorylation and can be handled by instracellular antioxidants. Injury, toxins , vaccine injury, infection, and stress can cause an over production of ROS which can exceed the generation of antioxidants leading to oxidative stress which can cause a lot of damage throughout the body. It causes inflammation, cell damage and even cell death. When the mitochondria become dysfunctional this can cause a rearrangement of the cytoskeleton which is framework of the plasma membrane and effects the balance between kinases, and phosphatases which promotes the ability of microorganisms to enter the cell and contributes to many inflammatory diseases. Excess ROS increases the permeability of intestinal epithelial. When levels of ROS are normal it will induce autophagy and microphagy which reduces inflammation. Reducing ROS levels too low can have the opposite effect because it would prevent it from inducing autophagy and we would lose the protection it gives us from infection.

Antioxidants can reduce oxidative stress but when homeostasis is achieved a person should only take maintenance doses. Over use of antioxidants can promote cancer by protecting it from apoptosis it also increases our risk of infection by reducing ROS levels too low.

Xenophagy

Xenophagy is the clearance of pathogens regulated by autophagy. Reduces Xenophagy leads to alterations of intestinal microbiota. This leads to a higher rate of infection. The microbiotia induce xenophagy in basal paneth cells which is induced by INF-y to maintain intestinal integrity. This impairs sensing of intracellular micro organisms in the intestinal endothelial cells and contributes to the progression of inflammatory bowel disease. Showing the importance on healing the intestinal tract so that the mucus membrane can be restored. Prebiotic fiber and the tryptophan metabolizing gut microbiota increases IFN-y. The commensal strains of E Coli increases IFN-y. Lactobacillus Gasseri increases IFN-y. Bacteroides Fragilis increases IFN-y and has been found to protect from many types of infections. Butyric Acid must be present to maintain IFN-y homeostasis. So it would also be a good idea to make sure the butyrate producing microbes are established.

IRGM (Immunity Related GTPase Family M protein) – is involved in killing of bacteria, vacuolar trafficking and acidification, it is also involved in autophagy. It is involved in fighting mycoplasmas. Damage to the digestive tract can impair it’s function which wold make you susceptible to mycoplasma infection. Inflammation inhibits IRGM. Our digestive tract needs to be acidic. If it becomes to alkaline then it creates an environment that promotes infection and dysbiosis and we lose our commensal microbiota.

True cause of illness and things that may help.

This is not medical advice I am posting this for educational and informational purposes.

 

 

I have a lot more to add to this but need a break and then I will finish it. I am going to add the things that negatively impact health and how it happens. Some of it I have covered but I have not covered the how part of it I only covered things that may help correct it.

Because probiotics can cause sepsis if you have ulcers or your gut is too porous I consumed a lot of mucilage and took bismuth in order to make sure my gut healed enough that would not happen.

To fully grasp the information here and to grasp the information in the links you will need to understand that Germ Theory and Terrain Theory have been proven wrong and that is why our Facebook group Synergistic Health decided we need a new theory “Enviroment and Biome Theory of Health”

https://iamajuicer.wordpress.com/2018/08/18/germ-theory-and-terrain-theory-are-wrong/

 

This article discusses how our microbiome effect the whole body even the blood brain barrier.

In this post I am going to try and show how our environment, biome of our environment and our won biome effect our health. This shows that our Facebook group Synergistic Health is correct with our theory “Environment and Biome Theory of Health” is correct and that germ theory and terrain theory are incorrect. Learning this will help people understand why their genes have very little impact on their health compared to the above mentioned things. I also list the things that may be able to correct them.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102499/

In all the research I have read gut diversity increases health and longevity and is found to be a commonality in centurions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051225/

There is a myth we should alkaize our digestive system must be acidic and alkalinity cause pathogenic and hydrogen sulfide producing bacteria to increase. This causes sulfation issues and increased ammonia getting the body stuck in a cycle. Bile and digestive enzymes become inhibited which cause high estrogen levels and copper will become biounavailable. You must break this cycle by getting ammonia levels down. BH4 levels get low when this happens eating protein increases ammonia levels. Short chain fatty acids balance our T cells so it is important to increase SCFA producing bacteria. I did a blog post on reducing ammonia levels (alkalosis). I did a post on reducing akalosis. I also did a summary of my notes which covers many of these things. If you search for akalosis and summary you should be able to find the information.

Fiber especially inulin increases the good gut bacteria. Exercise also increases our good gut bacteria. Reducing stress or learning to deal with stress increases our good gut bacteria. Ghee is high in butyrate which increases our good gut bacteria.

Egg and milk allergies indicate high Staphylococcus Aureus levels. This is caused by low microbiota that breaks up biofilms and produces natural antibiotics. This can also be caused by low lactobacillus paracasei, lactobacillus adolenscentis and lactobacillus rhamnosis levels.

I do not mention the strains that produce histamines because they are usually not a problem unless something is wrong in the body and they are needed for gut and body health. Avoiding the foods that cause them to produce histamines is more effective. Fermented foods, and aged meats and many cheeses will cause them to produce histamines. Some cheeses like Gouda and Parmesion have species of microbes that reduce histamines. This is why overconsumption of them can cause constipation because histamine stimulates stomache acid production. Those with low stomach acid production may benefit from eating foods that increase histamines.

An imbalance in our gut bacteria can lead to the production of high substance P levels which leads to systematic inflammation. If levels get high enough a person will start to lose their hair, they will get burning in their skin especially at night. The burning mostly occurs in the scalp and down the spine. I posted on how to reduce substance P.

When replacing a microbe you may be lacking it is normal to experience cramps and bloating until they get established. Taking the same probiotic daily can cause gut dysbiosis which is as bad as when candida goes pathogenic and can cause candida and H Pylori to switch from commensal to pathogenic. Probiotics should be alternated and one should take a break from them to let the microbial community balance out.

Most Bifidobacterium and Lactobacillus have some oxalate degrading abilities. The microbiota that produce vitamin B12 need chromium to be present to produce it.

Exercise increases our good gut bacteria. Stress and trauma increase our bad bacteria so it is very important to learn to meditate , pray and not to dwell on things you can do nothing about and do your best to get over trauma and do not hold grudges or be resentful or hateful. When we have a lot of negative emotions it increases the gut bacteria that increases adrenaline and it can tax our adrenals.

Diets rich on complex carbohydrates have been shown to prevent infection from food born pathogens. Processed sugar has been found to dramatically increase risk of infection from ford born pathogens.

Often times a persons microbiome is influenced by their sexual partners. Their sexual partner may have different metabolic factors so could appear to be unaffected. Usually a person sexual partner should be treated for dysbiosis or infection also to prevent constant reinfection or constant microbiome disruption.

Galacto-oligosaccharides increase absorption of nutrients, and increase the beneficial bacteria that are important in health mental health and cognition. It prevents constipation and helps protect from food born pathogens. It increases the microbiome that reduces anxiety and pain. It is derived from raw milk and is destroyed during pasteurizing. It also decreases the risk of pulmonary infections. It reduces almost all inflammatory markers in the body. It reduces intestinal inflammation. Galacto-oligosaccharid and fructo-oligosaccharid helps to prevent diabetes.

Our bodies secrete FUT2 to modulate our immune system and to keep our good microbiome health. Many things can make us deficient in FUT2 enzymes which causes a loss of our good gut microbiome and can lead to inflammatory bowel diseases and gut dysbiosis. Fructooligosaccharide and oligosaccharides can replace FUT2 until it is corrected. This is can also result from a deficiency in the microbiota that stimulate IL-22

A loss of our gut microbiome can cause raised zonulin levels which results in many food intolerances, metabolic issues , increase susceptibility to infection and if not corrected can lead to acidosis or alkalosis. Zonulin regulates gut permeability if levels get too low we can develop malabsorption issues. If zonulin levels get to high we can develop many health problems. It can also lead to interstitial cystitis and damage the blood brain barrier which results in the loss of protection of the brain and can lead to infection , encephalopathy and even chira which is a life threatening condition. Increased zonulin levels causes depression, anxiety and can even cause paranoid delusions and psychosis. Mold toxins can increase zonulin levels. BT Toxin found in GMO increase zonulin levels. Farm chemicals which are found to be heavy in our food increases zonulin levels especially glyphosate and glufosinate. It is very important to eat organic when possible. A diet high in fiber and resistant starches increases the microbes that reduce zonulin. Oddly our sterile lifestyles have caused a loss of the microbes that keep zonulin levels balanced. They have found those who are in nature and work with the soil a lot get the good microbes that keep zonulin levels balanced. Unfortunately glyphosate and glufosinate are killing those microbes in the soil which is making it more and more difficult for a person to get those microbes. Endotoxins and mycotoxins increase zonulin levels making us more prone to leaky gut. Leaky gut causes systematic inflammation which can lead to autoimmunity. Butyrate producing gut bacteria reduce zonulin levels helping to prevent leaky gut. Butter and raw milk is high in butyrate. Inflammation causes increased zonulin levels so microbes that reduce inflammation will decrease zonulin. When zonulin levels are how toxins the body would not absorb but would get excreted are easily absorbed which causes high heavy metal and other toxins levels in the body. High zonulin levels also result in food particles entering the blood stream which causes a lot of food sensitivities. This can be corrected by addressing the leaky gut. When zonulin levels are high it increases mast cell degranulation which can lead to mast cell activation syndrome or mastocytosis. This increases histamines leading to autoimmunity and allergies. This also will correct itself once zonulin levels are reduce. Those with high zonulin levels should avoid gluten and gliaden until it is corrected because they raise zonulin levels. High zonulin and high inflammation levels has been linked to just about all types of chronic illness. Inflammation can cause high zonulin levels, high zonulin levels can lead to inflammation creating a cycle that is difficult to break. Inflammation disables the immune system and is why so many illnesses like tick born illness, candida and many other infections are becoming epidemic. Almost all illness can be link to zonulin.

https://www.sciencedirect.com/science/article/pii/S2352551717300288

https://www.physiology.org/doi/full/10.1152/physrev.00003.2008

https://www.frontiersin.org/articles/10.3389/fmicb.2017.01936/full

https://www.tandfonline.com/doi/pdf/10.1080/21688370.2016.1251384

Our gut microbiome regulate our zonulin levels which regulates the tight junction layer. When zonulin is high then we develop leaky gut which causes chronic illness and even effects our brains. Our gut bacteria even regulate our HPA axis. Microbes that increase IL-10, T regulatory cells and reduce inflammation will reduce zonulin levels which will restore the tight junction protein layer. Also stress increases zonulin so microbes that reduce stress will also decrease zonulin levels.

https://www.tandfonline.com/doi/pdf/10.1080/21688370.2016.1251384

https://link.springer.com/article/10.1007/s00394-018-1784-0

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288588/

Our sterile lives have added to the increase in zonulin levels. Also nutrient deficiencies cause by over farming land and chemicals like glyphosate and glufosinate that chelate nutrients are causing nutrient deficiencies which increases zonulin. This indicates the the biome of our environment is also important for our health. It also indicates that our environment itself can influence our health.

http://www.pnas.org/content/106/39/16799.long

Nutrient deficiencies also stimulate zonulin and so do bad fats and excessive meat consumption. Excess vitamin B12 increases zonulin levels. I do not supplement with it, I nurture my gut microbiota that produce it and I make sure I get cobalt which they need to produce B12. On the other end of the scale zonulin deficiency can result in the inability to absorb nutrients. This shows the importance of learning to achieve homeostasis. I cannot find studies showing that inhibited zonulin causes malabsorption but I have noticed those who have high levels of the bacteria that inhibit zonulin and low levels of the ones that stimulate zonulin have malabsorption issues.

https://www.sciencedirect.com/science/article/pii/S0041134514008045

High zonulin levels can lead to decreased intestinal motility which causes the food to sit in the digestive tract and ferment instead of digesting. This increases the ammonia, hydrogen, sulfide and methane producing microbes which raises zonulin levels even higher. If I ever get a chance to write a book I will cover it in more detail. Once this cycle starts it is very hard to break and a person will not be able to absorb nutrients because their food is not getting broken down properly.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111132#s4

So all this being said the bigger the variety of gut microbes we have the more balanced our zonulin becomes.

Butyrate producing microbiota increase TGF-B which is needed to prevent some commensals from becoming harmful. A deficiency in TGF-B can lead to inflammatory bowel disease which can cause bile to be inhibited. The most important of these are F Prausnitzii, Clostridium Leptum, Eubacterium Rectale and Roseburia. If deficient in IL-10 or TGF-B the microbiota that stimulates bile will become pathogenic in nature IL-10 and TGF-B work together to keep them in check so they continue to function properly. I discuss bile in more detail at the end of this article.

https://link.springer.com/article/10.1007/s00535-017-1350-1

https://www.tandfonline.com/doi/full/10.3109/0284186X.2015.1054949

Raw potatoes, inulin, chickpeas and other legumes feed the gut bacteria that prevent gliaden and gluten intolerance. Too much of these can increase the glucose levels in the blood. That may be good for those with malabsorption but high glucose levels can lead to cancer and other health problems.

Increased CB1 receptor activation causes leaky gut which can lead to food intolerances from our gut becoming too porous. This can lead to increased LPS levels which can lead to endotoxemia and sepsis. Increased zonulin also does this. Stress increases zonulin.

The PH of the gut and bladder should be between 4 to 5. The lower the number the more acidic the high the number the more alkaline. We do not want alkaline it causes infection and gut dysbiosis. Candida and H Pylori will go from commensal to pathogenic.

Bloating can be from taking too much of a certain probiotic which can lead to dysbiosis , inflammation, ulcerations, or high histamines. High histamines will cause acid reflux. Low histamine inhibits bile and will cause bile reflux constipation and low stomach acid production. If you have low histamines fermented foods will increase the histamine producing bacteria but be cautious do not increase them too far. We can also become bloated if candid or H Pylori go from commensal to pathogenic.

Increased gut permeability (leaky gut) can lead to bone loss, autoimmunity, and many metabolic issues.

Our gut bacteria need carbohydrates but many avoid them. There are good carbs and bad carbs.

A microbiotia accessable carbohydrate diet increases beneficial bacteria that produce short chain fatty acid. This consist of fiber and carbohydrates. This increases the bacteria that produce short chain fatty acids. If we do not produce enough SCFA we will become constipated and bile production will become inhibited. This will also happen if we develop malabsorption from having high bacteroidetes, methane producing and sulfur digesting bacteria. They contribute to malabsorption, constipation and inhibited bile production from a lack of SCFA in the body. Our blood glucose levels will also become very low and we may develop high insulin levels. Clostridium infection is also a major cause of this and indicates we are lacking the microbiota that protect us from it. This can cause a cycle that is hard to break because bile is needed to prevent clostridium infection.

High histamines usually indicates low bifidobacterium levels. Bifidobacterium degrade histamines. Low Bifidobacterium can cause weight gain in some people and can lead to anxiety, difficulty sleeping and difficulty concentrating. Our histamine degrading bacteria need vitamins A,C, E and Zinc. Bifidobacterium which there are many species produce folate. Most Bifidobacterium increases IgA which prevents food intolerances and allergies. Bifidobacterium also break down gliaden. Excess gliaden can raise zonulin levels leading to the tight junction layer becoming more permeable resulting in leaky gut.

Lactobacillus needs vitamin A and consuming it has been shown to restore lactobacillus. Most lactobacillus prevent candida and fungus infections. Most Lactobacillus prevent lung infection. Most Lactobacillus increase IL-10. IL-10 is needed for commensalism. Those deficient in Lactobacillus will be extremely underweight.

https://pdfs.semanticscholar.org/b2c3/c191fc3c8efbd745d5583d6be940a4dcae06.pdf

Most probiotics should be taken with an oligosaccharide. They help feed them and get them established. Pectin also protects the good bacteria helping it to thrive. Olive oil has been found to prevent them from making TMAO. If TMAO levels get too high we can develop a fish like smell, diabetes and/or cardiovascular disease.

Lactobacillus Reuteri increases oxytocin which helps keep us calm and helps prevent depression. It also helps prevent diarrhea. It increases intestinal absorption of nutrients. It prevents cavities and promotes dental health. It protects against pathogens and parasites. It has been shown to help with autism. L Reuteri produces food need by most of the other commensal bacteria. It requires sugar to produce the food the commensal microbes need. L reuteri also help prevent asthma. Helps restore normal vaginal and bladder microbiome. If you are sensitive to sugars and starches it could be an indication you are deficient in L Reuteri. L Reuteri breaks down sugars and starches. A deficiency in Lactobacillus Reuteri can also contribute to milk allergy and a lower resistance to pain. It prevents gingivitis and periodontal disease. It helps keep H Pylori commensal. L Reuteri improves the production of bile.

Clostrium Leptum has been found to be low in those with inflammatory bowel disease and Chohn’s disease. It breaks down carbohydrates and produces butyrate. It reduces inflammation.

I believe L Reuteri and L Fermentum are the same species. Often times research papers state that they are the same species.

Lactobacillus Fermentum found in raw goats milk protects from urinary tract infection and food born pathogens. It has been shown to increase other lactobacillus bacteria. This would help those who have difficulty gaining weight. It is resistant to most antibiotics and has been found to transfer that ability to the other but microbes. This also would help with lactos intolerance. L Fermentum prevents skin rashes and eczema By increasing TH1. It prevents IgA related allergic disease. L fermentum helps prevent urinary infection. Low I IgA levels are common in inflammatory bowel disease and those who have malabsorption disorders. Reduces endotoxins. Helps protect from cavities and gingivitis.

Bacteroides Vulgatus increases bile production, if levels are low a person is susceptible to inflammatory bowel disease. If levels get too high a person will develop celiac disease. This occurs if a person is lacking the microbiotia that stimulate IL-10, SMAD3 and TGFB.

Pediococcus pentosaceus prevents clostridium infection of the digestive system by reducing zonulin. This would improve bile production. It also reduces inflammation. It produces natural antibiotics that fight bacteria.

Bacillus Coagulins prevents lactose intolerance. Helps break down food better increasing nutrient absorption. Helps prevent diarrhea. Prevents gas, bloating and intestinal inflammation. Helps prevent constipation. Reduces endotoxins. Improves bladder and vaginal health. Helps keep H Pylori commensal.

Bacillus Subtilis produces food needed by the other commensal microbes has been shown to balance the gut microbiome. It prevents gastrointestinal and urinary tract infection. It is found in soil. It stimulates IgM, and IgG which important part of immune function. Protects the DNA and has antioxidant properties. Helps prevent diabetes and cardiovascular disease. If it is supplied with lactulose which is found in raw milk but destroyed during pasteurization it will prevent constipation. It reduces inflammation and has been shown to reverse irritable bowel disease. It Balances our T cells which would prevent allergies and autoimmunity. It prevents H Pylori and Candida from becoming pathogenic. Reduces endotoxins and heals the liver and kidneys. It prevents skin rashes and lesions. It increases our ability to tolerate heat. Helps break down phytic acid preventing it from being and antinutrient. B Subtilis has been shown to reduce blood pressure and prevent atherosclerosis. B Subtilis communicates with the body to let is know what is going on. It kind of acts like a soldier and a nurse. It stimulates IFN-y in spleens of mammals which is an important part of the bodies ability to fight infections. Seems more important for fighting infection then dendric cells and natural killer cells. IFN-y prevent viruses from being able to adhere to cells. Increasing IFN-y increases CD8 molecules. Those who are TH1 dominant should avoid this strain it increases TH1.

https://iai.asm.org/content/75/3/1167

Lactobacillus sanfranciscensis helps degrade phytate preventing them from being and antinutrient. Decreases gut permeability and prevents obesity. Reduces symptoms of inflammatory bowel disease. It is found in raw sour bread dough.

Lactobacillus pentosus found in fermented olive products. It helps prevent food born pathogens. It helps break down carbohydrates. Helps reduce symptoms of lactose intolerance. It can break down a wide variety of sugars and carbohydrates.

Lactobacillus Salivarius reduces histamines. Protects the throat, mouth and nasal cavities from infection. It helps prevent cavities. They help keep the ph of the intestines balanced. It helps with nutrient absorption especially folate. It reduces nausea, bloating, cramping and inflammation in the digestive system. It protects us from food born pathogens. It protects us from getting strept throat and halitosis. It lowers cortisol levels and reduces stress and anxiety. L Slivarius increases endurance. Helps prevent lactose intolerance. It prevents flatulence. Has been shown to protect the pancreas. Has been shown to reverse dermatitis.

Oxabacter Formigenes reduces oxalates and reduces pain. It is the primary oxalate degrading bacteria in the gut.

Lactobacillus Paracasei inhibits infection and helps reduce ammonia producing bacteria. It is a subspecies of Lactobacillus Casei which has many of the same benefits. It also prevents anxiety but not depression. L paracasei especiall ssp Casei prevents obesity. L Casei reduces the duration of infections. L Paracasei helps prevent allergies. L paracasei and ssp L Casei should not be taken by those with high histamines. It prevents halitosis and cavities. It has been shown to protect the nasal cavities, mouth and throat from infection.

L Casei protects us from pathogens that cause diarrhea and antibiotic induced diarrhea. It improves colon health and inceases the commensal bacteria that help prevent depression and anxiety. Helps protect the gums from infection. Has been shown to protect the health of the pancreas. Increases IL-10 and TGF-B.

Lactobacillus Casei ssp shirota prevents constipation. Increases serotonin. It improves mood and prevents depression. It has the best long term effects at improving mood.

Lactobacillus Brevis prevents urinary and intestinal infection by regulating the PH of the digestive system and renal system. It helps keep it from getting too akaline. Lactobacillus Brevis improves cellular immunity it protects the gut from excess bile acids and keeps H Pylori commensal. It produces natural antibiotics that protect the gut from pathogens.

Streptococcus Thermophilus is needed by most of the gut bacteria to get established especially lactobacillus debrueckii. S Thermophilus helps with lactose intolerance. It prevents cavities and infection in the nose, throat and mouth. Helps prevent inflammatory bowel diseases. It accelerates healing in the gut.

Lactobacillus Debrueckii is needed to establish the commensal microbiome and to prevent C Diff infection. It also prevents inflammation. It is found in butter milk. It also helps keep H Pylori commensal. It helps degrade milk proteins. It also helps prevent liver disease. L Debrueckii also prevents fungus infection. It also prevents obesity.

lactobacillus Plantarum is needed to balance our gut bacteria which helps prevent dysbiosis. It also helps prevent diabetes. Helps prevent candida and fungus infections. Helps prevent inflammatory bowel diseases. It reduces HIV, enhances memory and reduces brain inflammation. Reduces abdominal pain.

Saccharomyces Boulardii helps prevent autoimmunity, protects from diarrhea caused by pathogens. Helps keep H Pylori commensal. Helps prevent inflammatory bowel. Saccharomyces Boulardii helps with gluten intolerance and reduces symptoms of SIBO.

Bifidobacterium bifidum helps in the production of many B vitamins. Prevents celiac diseas, milk allergies and many other food sensitivities. Reduces histamines. Improves immune function. Prevents ulcers and diarrhea. It is important for vaginal homeostasis. Has been shown to reduce symptoms of inflammatory bowel diseases. Prevents constipation and lung infection. Prevents pouchitis and infections in the lining of the intestines. Has been found to improve immune function. Prevents eczema. It also produces the B vitamins common to Bifidobacterium but also produces vitamin K2. It helps those who do not produce enough lactase because it breaks down lactose. Increases red blood cell production helping to prevent anemia. Has been shown to reduce the severity of the flu and common colds.

Bacillus Coagulans found in the soil , it improves bowel movements, helps with inflammatory bowel diseases, reduces bloating and pain in the digestive system. It also decrease the inflammatory C-reactive protein which is high during infection. It reduces intestinal gas. Reduces the risk of infection especially by influenza. Has been shown to reduce arthritis symptoms. It has been shown to help with gluten intolerance and allergies. It has been shown to reduce symptoms of SIBO. It has been shown to prevent food born pathogens. Is effective at fighting a broad range of pathogens. It reduces symptoms of arthritis if it has an adequate supply of inulin.

Saccharomyces Cerevisiae reduces oxidative stress and free radicals including hydroxy radicals and prevents excess nitric oxide production. Helps prevent iron toxicity. It stimulates the good inflammatory cytokines while inhibiting the bad ones. It helps in developing humoral immunity. Can reduce candida infection but if taken in excess will cause symptoms that are exactly the same as candida infection and is often times more common in those who are believed to have candida infections in the bladder. It helps those who have phenylketonuria or proteinuria it breaks down proteins like phenylalanine. Saccharomyces Cerevisiae prevents acne.

Lactobacillus gallinarum prevents urinary tract infection and reduces oxalates. It reduces symptoms of allergy. It helps break down phytic acid preventing it from being an antinutrient.

Bacillus Subtilis found in soil protects and heals intestinal epithial cells. It is improtant in the proper absorption of nutrients. If deficient in B Subtilis you will suffer from Malabsorption syndrome. It helps keep our T cells balanced. It is needed for digestion of carbohydrates. Has been shown to keep H Pylori commensal and fight food born illness. Has a broad range of antimicrobial properties.

Lactobacillus Helveticus is found in cheeses like parmesian, cheddar, swiss cheeses, buttermilk and cheddar cheese. Protects the gut health and is a butyrate producing bacteria. It reduces neurological inflammation and restores cognitive function. It helps prevent anxiety and depression. It improves sleep and prevents lung infection. It reduces parathyroid hormone and improves calcium metabolism. It improves learning and cognition. It fights candida and prevents dermatitis. It fights cancer and reduces inflammation. L Helviticus also prevents lung infections. It is and ACE inhibitor so prevents high blood pressure. It is important for whole body health and protects the liver and kidneys. It helps prevent lactose intolerance. It reduces anxiety and promotes the feeling of well being. It prevents mood swings and aggressive behavior. It helps prevent depression.

Bifidobacterium Longhum helps prevent anxiety and depression, and improves cognitive function, it helps prevent viral infections and symptoms of ulcerative colitis. B Infantis is a subspecies which has been shown to protect against polio. B Longhum protects the lungs from infection. It prevents food born illness and prevents candida from becoming pathogenic. It reduces symptoms of gout and prevents inflammation. It prevents allergies and celiac disease. It reduces endotoxins and prevents fatty liver disease. It increases biotin levels. It reduces bloating in the gut especially ssp Infantis. B Longhum improves sleep and prevents anxiety. Reduces depression caused by stress by reducing cortisol. It prevents liver disease and produces B12 and Folate.c It improves bone health and fights cancer. It decreases TH1 and TH17 cytokines. B Longhum also reduces aggressive behavior. B Longhum improves nutrient absorption. Reduces histamines. B longhum stimulates the vagal nerve.

B Infanis increases tryptophan. Decreases bloating. Bifidobacterium Longhum also helps prevent lactose intolerance. It detoxes serotonin metabolites. It decreases adrenalin levels and restores the HPA axis. It reduces inflammation and increases lifespan. It prevents ulcers. It helps prevent lactose intolerance. Increases IL-10 and IL-1B which seems contridicting but IL-1B is needed to increase intestinal motility. IL-10 keeps IL-1B from causing inflammation and immune issues.

Bifidobacterium Infantis increases tryptophan, serrotonin and GABA precursors. Helps prevent inflammatory bowel diseases. B Infantis increases T regulatory cells which helps keep the immune system balanced. B Infantis promotes the production of IgA which is usually low in those with malabsorption and inflammatory bowel disease.

B Infantis reduces histamines. B infantis decreases intestinal bloating, pain and gut distention (enlarged or inflammed). B Infantis increases tolerance to pain. B Infantis has been shown to protect the health of the pancreas.

Bifidobacterium Breve helps protect from food born pathogens and diarrhea. It also helps prevent allergies. Has been shown to improve intestinal health. Reduces anxiety and improves cognition. Reduces histamines. It helps the body absorb nutrients. It reduces bloating and inflammation. Prevents obesity.

Bacteroides Thetaiotaomicron secrete natural antibiotics which keep the gut balanced. It is also responsible for innate immunity in the intestines. It reinforces the mucous membrane. It reduces inflammation. It also helps break down carbohydrates. Prevents constipation and improves bile production. But high levels can promote Clostridium infection.

Bacteroides Ovatus helps break down carbohydrates and feeds other commensal bacteria. It breaks down the most difficult fiber that none of the other microbiota can.

Lactobacillus Rhamnosus helps prevent anxiety and depression by upregulating GABA. L Rhamnosus also prevents lactose intolerance, asthma and allergies. It also prevents skin rashes and eczema. L Rhamnosus also prevents urinary infection. Helps restore normal vaginal and bladder microbiome. Helps prevent candida and fungul infections. Helps prevent inflammatory bowel diseases. Reduces oxalates. Prevents food sensitivities. Breaks down histamines. Reduces endotoxins and inhibits biofilm formation. It simulates phagocytosis which helps fight infection. Phagocytosis is inhibited in those with immune deficiency. Reduces histamines. Rhamnosus improve bowel movements by increasing intestinal motility. Has been shown to prevent chronic fatigue.

Lactobacillus Acidophilus prevents excessive weightloss and reduces inflammation. Has been shown to reduce symptoms of arthritis. L Acidophilus increase CB2 receptor expression. Prevents urinary and bladder infection and helps keep the ph of the bladder and intestines balanced. Helps prevent candida and fungul infections. Helps prevent inflammatory bowel diseases. Prevents celiac disease, milk allergies and food sensitivities. L acidophilus helps with FODMAP intolerance and has been shown to reduce SIBO. It reduces pain by stimulating the opioid receptor. Helps prevent acne. Helps prevent allergies and food intolerances. Helps prevent infection in the bladder and intestines by balancing the ph. If we become too alkaline it promotes pathogen growth. It also prevent vaginal infections. Has been shown to protect the health of the pancreas. Increases IL-10.

Mycobacterium Vaccae helps prevent brain inflammation, anxiety and depression. It also improves cognitive function. It is found in healthy soil in forest among decaying folage. Supposedly eating leaves from a plant can give you this. It induces a strong T cell response when first establishing in the body and then slowly declines as it gets established. Once established it increases T regulatory cells. It helps fight tuberculosis.

Almost all bifidobacterium prevent depression and anxiety but can cause weight loss so those who are under weight my want to be cautious in taking these in excess. Red Wine increases Bifidobacterium. The bifidobacterium also decreases adrenalin levels.

Sophora has been found to increase most of the bacteria that prevent anxiety and depression.

Lactobacillus Iners promotes vaginal dysbiosis so should be avoided , high levels can cause miscarriage. It increases risk of contracting sexually transmitted diseases. One good thing about it is it prevents HPV infection.

Lactobacillus Jensii reduces the risk of contracting sexually transmitted diseases and renal infection. It helps with the break down of milk. It reduces the population of other Lactobacillus which can help with obesity. Lactobacillus Jensii produces chemicals that inhibit HIV. Helps restore normal bladder and digestive microbiome. Helps protect from HPV infection. It helps maintain the proper PH of the intestines and the bladder.

Lactobacillus Crispatus causes weight loss in those who are obese and protects from infections in the renal system, bladder and prevents sexually transmitted diseases. It helps keep the ph of the bladder and digestive system balanced. Helps restore normal gut and bladder microbiome. Helps protect from HPV, HIV and many other types of infection. It prevents vaginal odor.

Lactobacillus Johnsii requires purines to survive so needs purine producing commensals or purines consumed in the diet. It produces natural antibiotics that protect the gut from infection and prevent H Pylori and Candida from becoming pathogenic. It has been shown to thicken the mucous membrane in the gut and helps heal peptic ulcers. It restores the proper number of IgA, IgG and CD8+ cells which are low in tick born illness and inflammatory bowel and malabsorption disorders. It helps prevent skin lesions. It has been shown to reduce diabetes and even reverse it in some. L Johnsii prevents insulin resistance and allergies. It also prevents vaginosis. Those with interstitial cystitis or high TH17 levels would want to avoid this one because it increases TH17 levels along with COX2 which is high in interstitial cystitis, psoriasis, and lupus. It would help restore nutrient absorption in those with malabsorption.

Lactobacillus Kefiranofacians is found in kefir and fermented milk. It prevents cavities and biofilm formation. It does not survive in the gut long so you would have to gargle with it. It also helps with constipation. It stimulates the intestines to produce more mucin increasing the mucous membrane in the gut which helps with colitis. Those with high TH1 levels would want to avoid it because it increases TH1 levels.

Lactobacillus Kimchii increases phagocytosis which would not be good in those with a hyper immune system but would help those who have an inhibited immune system. It is found in kimchi. Kimchi also contains Lactobacillus Sakei which inhibits biofilm formation.

Lactobacillus Plantarum has potent antioxidant abilities. It helps maintain proper intestinal permeability and helps with malabsorption disorders. It produces antimicrobials that fight gram positive and gram negative bacteria. It accelerates gut repair. It helps with chron’s and inflammatory bowel disease. It reduces skin rashes and eczema. It has been shown to help with diabetes. It prevents diabetes and high blood pressure. L Plantarum also prevents biofilm formation. L Planatarum increases muscle mass, muscle strength and endurance. Helps prevent candida and fungul infection. Helps prevent inflammatory bowel diseases. Reduces oxalates. Breaks down histamines. L Plantarum improves intestinal epithial health. It produces L-Lysine which improves our bodies ability to use calcium. It has been shown to improve mental health. It is improves the absorption of nutrients into the body. It helps remove toxins from the body.

Lactobacillus Pontis increases NOD2 which fights viruses but is not good for those with inflammatory diseases or inflammatory bowel disease.

Bifidobacterium Adolenscentis helps break down milk proteins, promotes normal bowel movements, produce many of the same vitamins that most Bifidobacterium produce which includes B1, folate, B12, biotin and riboflavin. It also produces vitamin C but not in high enough amounts to provide the body with adequate levels of vitamin C. It like most Bifidobacterium dephosphoralizes phytic acid. Which prevents the antinutrient effect of Phytic Acid. If a person is low in Bifidobacterium then phytic acid will deplete their bodies of nutrients. It helps fight Coxsackievirus and other viruses. If a person is deficient in Bifidobacterium they are more prone to Norovirus infection. It along with most bifidobacterium prevents obesity, cardiovascular disease and diabetes.

Streptococcus Salvarius prevents infection in the throat nose and mouth. It also produces natural antibiotics that kill harmful bacteria. Prevents food allergies. It also prevents lung infection.

Streptococcus Mitis prevents infection in the throat nose and mouth.

E Coli Nissle prevent E Coli infection, prevents halitosis, helps prevent infection in the mouth , throat and nose. Helps with inflammatory bowel diseases. E Coli Nissle protects us from it’s pathogenic cousins. It also protects from other food born illness.

Lactobacillus Salvarius prevents cavities and prevents biofilm formation and prevents dental plaque. Helps prevent fungul infection and candida.

Lactobacillus Coagulans (Lactobacillus sporogenes ) helps prevent inflammatory bowel diseases. Has been shown to prevent diabetes. It enhances protein absorption and increase muscle healing, improves muscle recovery time and increases endurance. It inhibits fibrosis which would help with fatty liver disease and COPD. It increases butyrate producing bacteria. It decreases abdominal pain. It requires oligosaccharides. It improves bowel motility which prevents constipation. It reduces symptoms of inflammatory bowel diseases. It helps improve feeding tolerance. In other words it helps restore your appetite.It prevents parasite infections and has been shown to protect against the flu and adenovirus. It has been shown to reduce vaginosis. It also protects from many pathogens that cause diarrhea.

Lactobacillus Gasseri prevents halitosis. Helps restore normal bladder and gut microbiome. Reduces oxalates and histamines. Helps protect from HPV infection. It reduces menstrual pain. Reduces allergies and asthma. Helps break down phytic acid preventing it from being and antinutrient.

Bifidobacterium Animalis prevents food allergies and reduces oxalates. Prevents constipation speeds up food transit time. It prevents bloating, nuero inflammation, oxidative stress, and increases serrotonin, dopamine and norepineprhine by inhibiting MAO activity. Prevents obesity and anemia. It protects from polio and rotavirus. It reduces the length of the flu and prevents lung infection. I reduces allergies but increases TH1 levels. It reduces inflammation and increases T regulatory cells. It increases good gut microbes and decreases the bad. Improves digestive health. Prevents diarrhea and constipation. Helps with colitis and inflammatory bowel disease. It enhances immunity. It helps prevent celiac disease. It degrades oxalates. It improves nutrient absorption. It reduces stress hormones helping to reduce anxiety.

Bifidobacterium Adolescentis prevents food allergies and reduces oxalates. It prevents diarrhea from pathogens and prevents constipation. It helps protect from the rotavirus. Prevents asthma. Inulin increases B Adolescentis. It is fed by F Prausnitzii. It helps reduce fatty liver disease.

Akkermansia Muciniphila helps prevent obesity and helps to produce short chain fatty acids and is usually low in those will malabsorption issues. Deficiency in Akkermansia Muciniphila can lead to diabetes. Akkermansia Muciniphila also protect us from inflammation. It is important in homeostasis in the gut. It also produces oligosaccharides which feed our good gut microbes. It helps produce SCFA which are needed by the body and our microbiome. It helps maintain the shape and health of the mucous membrane in the gut. Low levels of Akkermansia Muciniphila results in a thinner mucous membrane making us more prone to infection and inflammatory bowel diseases. A deficiency in Akkermansia can result in appendicitis. Arabinoxylin, Inulin , fructoligosaccharide, oligofructose increases Akkermansia. Polyphenols in pomegranate, grapes, grape seed extract , and navy beans increase Akkermansia. Cod liver oil also increases Akkermansia. When there is a wound in the gut Akkermansia will go to the site of the wound and signal the body it needs to repair that area. This is one of the most important microbes for gut health. If we are deficient in it bacteroidetes leves get to high, bile production becomes inhibited and our bodies do not secrete pancreatic enzymes. I discuss the consequences of high bacteroidetes levels at the end of this post. Increased CB1 receptor activation reduces Akkermansia, inhibiting CB1 receptor increases Akkermansia but inhibiting CB1 increases depression and anxiety. Akkermansia needs Faecalibacterium Prausnitzii and vice versa. There is research showing if Akkermansia levels get too high it can increase zonulin levels so though it is a key mcirobiota in the regulation of our health homeostasis should always be the goal.

Clostridium Butyricum help prevent many food born pathogens, helps produce short chain fatty acids, it prevents diabetes and helps keep the sulfur digesting and ammonia producing bacteria like Bacteroidetes and Firmicutes from getting too high. If those are high a person can develop diabetes, malabsorption from inhibited bile production and inflammation. It prevents insulin resistance. Clostridium Bytyricum also protect from bartonella.

Faecalibacterium Prausnitzii Faecalibacterium a deficiency can lead to irritable bowel syndrome. Produces butyrate from fiber. A deficiency in F Prausnitzii can lead to asthma, obesity, depression ,Chohn’s disease and inflammatory bowel diseases. A deficiency in this can lead to high TH17 levels resulting in psoriasis. Those with cardiovascular disease and Type 2 diabetes are usually low in F Prausnitzii. Akkermanis Municiphila needs it and vice versa. Prevents inflammation.

It also helps balance the immune system. It needs Akkermansia to thrive. Oligosaccharides increase F. Prausnitzii. It prevents celiac disease. It induces IL-10. It is necessary for fatty acid oxidation. It produces butyrate. It produces Salicyclic acid which is what they make aspirin from. It produces raffinose a type of oligosaccharide that decreases gut permeability which prevents leaky gut. It along with other commensals form biofilms that help protect and heal the gut. Decreases zonulin which preserves the integrity of the tight protein layer. If zonulin levels get too high a person will develop lactose, gluten and gliadin intolerance.

Enterococcus faecium prevents listeria infection and prevents infection from it’s pathogenic cousins. There is a human species which is non pathogenic and an animal species and the animal species is pathogenic to humans. I view this one as a dangerous pathogen even though it is used in probiotics when the body is weak it can make a person very very ill.

Weissella Cibaria also prevents halitosis, cavities, and this one also reduces skin lesions. It also reduces Hydrogen Sulfide and inhibits biofilms. Weisella Cibaria is found in kimchi and fermented milk. It prevents inflammation caused by endotoxins. It also prevent Nirtic oxide induced by endotoxins and promotes the healing of intestinal epithelial cells. It inhibits biofilm formation of pathogenic microbes.

Preovotella Histicola reduces arthritis, increases T regulatory cells and IL-10 which help keep the immune system balanced and reduces TH17. These are often a problem in those with tick born illness or mycoplasma infection. Reduces allergies.

Collinsela Aerofaciens increases intestinal PH which prevents pathogens and keeps candida and H Pylori in their commensal forms. It has been shown to prevent irritable bowel syndrome. It requires maltose, lactose or glucose. Whole grains increase C Aerofaiens. It prevents arthritis by inhibiting IL17.

Lactobacillus Bulgaris increases life span. Helps maintain the proper PH of the bladder and intestines which prevents infection and dysbiosis. Prevents the bladder and intestines from becoming alkaline. If they become alkaline candida and H pylori will go from commensal to pathogenic. It balances the microbiome in the digestive system. It also helps prevent lactose intolerance. It helps prevent liver disease and has been shown to reduce the risk of getting the common cold. It prevents dermatitis and eczema. It has been shown to help with inflammatory bowel disease. It prevents tooth decay and also prevents infection in the intestines and prevents pouchitis. It prevents constipation. It helps neutralize many toxins.

Odoribacter Splanchnicus a loss of Odoribacter causes a loss of SCFA availibility which leads to inflammation and low glucose levels. Deficiency in O Splanchnicus can lead to hypertension and diabetes. Low levels of O Splanchnicus can also lead to interstitial cystitis. It is important for absorption of nutrients and in maintaining a healthy gut. Has been shown to prevent atherosclerosis. Requires glucose, galactose, salicin, trehalose, arabinose, fructose or mannose. Inhibits many of the sulfur digesting bacteria that can cause high sulfite levels and high hydrogen sulfide levels. O Splanchnicus also breaks down phytoestrogens found in many plants.

Lactinifactor Longoviformis breaks down phytoestrogens found in many plants.

Arthrobacter Agilis it produces carotenoids which the body can convert to vitamin A. It reduces the risk of Parkinson’s disease. They degrade many pesticides. It prevents fungus infection but I am not comfortable with Arthobacter species because some of them produce antifreeze and I cannot find any research to show with this one did or not. I do not feel this is a safe probiotic and I have not spoken to anyone who had used it.

Eubacterium Halli it produces butyurate from acetate, glucose and lactate. It produces vitamin B12. It is important for homeostasis in the body and produces SCFA. It improves insulin sensitivity and normalizes blood glucose levels. It cannot process complex carbohydrate and needs bifidobacterium to exist. It makes some carcinogens harmless.

Arthrobacter Globiformis uses sugar as it’s main source of food. It uses sugar and ammonia. It’s byproducts are nitrogen and hydralimine. I do not know the health effects of these but it can break down many toxins in the enviroment but I do not feel comfortable using these as a probiotic I have not seen enough research on the use of this. Their are many of the Arthrobacter species that are used for probiotics and almost all of them break down some form of toxin but I cannot find research on their safety or effectiveness.

Pediococcus acidilactici it has been shown to reduce gastrointestinal distress. It prevents infections by food born pathogens and has been shown to stop bloody diarrhea. It also prevents constipation. Has been show to stop excessive vomiting. It has been shown to fight pathogenic parasites. It increases IL-10 and T regulatory cells which would balance the immune system. It has also been shown to fight fungal infections.

Most Bacillus species convert genotoxic substances to non toxic substances. Bacillus species are found in the soil and in humans. Some can be pathogenic. Man soil based bacteria improve nutrient absorption. There are other strains of Bacillus species but I did not list them because they have the ability to produce endotoxins. Bacillus species help break down food better which improves nutrient absorption. They should be taken with food or they do not get established well. Many of the Bacillus species secrete amylase and lipase. Amylase helps break down carbohydrates and lipase breaks down fats. Bacillus species may help those with malabsorption issues. Bacillus species detox a lot of toxins including mycotoxins found in fungus and molds. Mycotoxins can cause birth defects, sterility, it can increase estrogen levels. Most bacillus species can detox mycotoxins zearalenone, and aflatoxin but other mycotoxins that get broke down are species specific. Most Bacillus species train the immune system on how to fight pathogens. Most bacillus species reduce the risk of diabetes and cardiovascular disease. Most bacillus species help prevent leaky gut and promote healing of the gut.

Bacillus Lacterosporous is found in soil and humans. It fights fungus. Helps prevent leaky gut. It also fights mycoplasma infection. I have not seen studies on the effectiveness or safety of this microbe.

Bacillus Firmis promotes the differentiation of B lymphocytes to Ig producing and secreting cells. It stimulates the repair of blood vessels.

Bacillus Clausii stimulates the production of IgA but requires GALT. Prevents lung infections has been used successfully to treat those who get recurrent respiratory infections. Has also been used successfully to treat acute diarrhea. Studies show it is safe for human consumption. It protects the body from endotoxins.

Bacillus Licheniformis prevents biofilm formation of pathogens. Prevents the build up of amyloid plaque which contributes to amyloidosis and Alzheimer’s. Amyloid can also destroy beta cells leading to diabetes.

Bacteroides Fragilis promotes the production of GALT.

Phages P. Aerugonosa protect against E Faicalis and many food born pathogens.

Bacteroidetes- there are many species. Meat consumption increases their numbers. If bacteroidetes get too high it can result in weight gain or weight loss from malabsorption. It can cause the inability to absorb fats preventing bile production. It can cause the pancreatic enzymes to become inhibitited and cause phenylketonuria which results in high ammonia levels. It can cause BH4 enzyme deficiency, which can lead to CBS upregulation which can lead to high sulfite levels. This can cause the citric acid cycle to shut down leading to high estrogen levels, high unbound copper levels which farther inhibit the bodies ability to produce bile. This farther increases estrogen levels and levels of unbound copper. This lead to inflammatory bowel disease and malabsorption issues. A person with high Bacteroidetes levels will be high in butyrate and proprianic acid, acetate levels may be high also. They will be low in malanic acid. This also leads to high ammonia levels which causes many other health issues and causes Candida and H pylori to go from commensal to pathogenic. Many with this problem will develop bile acid gird. This also makes someone prone to clostridium infection along with many other pathogens.

If this persist long enough a person can develop interstitial cystitis. This is a common problem in those born by C section and who are formula feed. This also leads to a lot of food intolerances especially milk and glutin along with gliaden. This also can result in thiamine deficiency.

Consuming high amounts of meat can result in high bacteroidetes, methane producing bacteria and increased sulfur digesting bacteria. This can result in high levels of sulfite which will interfere with sulfation and cause many health issues. It can also cause high levels of hydrogen sulfide which will lower blood pressure at first then if levels get high enough it will increase blood pressure and cause severe inflammation. Bile production and production of pancreatic enzyme will become inhibited. High sulfite levels makes a person more susceptable to Salmonella infection. This also inhibits bile production. Butyrate ;producing bacteria help restore bile production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023267/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953422/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282957/

Another thing that inhibits bile production is extended use of antibiotics. It reduces our good gut microbiome. Muscrarlis Macrophages detect our good gut microbiomes LPS. With the decrease in our good gut microbiome and loss of their LPS to signal muscarlis macrophages dysbiosis occurs which leads to inhibited intestinal motility which causes a loss of bile production and pancreatic enzyme production. Supplementing with commensal LPS has been shown to reduce the symptoms and increase bile flow.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149228/

https://www.cell.com/abstract/S0092-8674(14)00735-1

https://www.cell.com/cell/pdf/S0092-8674(14)00867-8.pdf

A loss of bile production prevents nutrient absorption, the pancreas will not receive the feedback from our intestines and will quit producing enzymes. This result in malabsorption especially of oil soluble nutrients because bile is need to break down fats. This will also cause LDL levels to get low and HDL levels to because high. This imbalance causes HDL to become inflammatory.

A loss of serrotonin producing gut bacteria negatively impact gut health. Tryptophan helps restore gut health. Strange thing is the first three or four days I took tryptophan I had a herx type reaction. It must have been from die off of the bad gut microbes as the good increased. This can lead to damage to the central nervous system.

http://www.pnas.org/content/115/25/6458

https://www.gastrojournal.org/article/S0016-5085(16)34896-X/abstract

Grape seed extract helps restore bile flow.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817264/

If normal bile function is not restored it effects the whole body and can lead to diabetes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073382/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319718/

https://www.frontiersin.org/articles/10.3389/fmed.2017.00163/full

Good articles on reducing candida when it turns pathogenic.

http://www.gestaltreality.com/2013/09/16/how-to-eliminate-candida-biofilms/

https://www.yeastinfectionadvisor.com/candidadiet.html

https://www.theguthealthprotocol.com/wp/the-alkalizing-myth

https://www.selfhacked.com/blog/treat-cure-candida/

https://www.thecandidadiet.com/candida-fighting-foods/

Sometimes people confuse candida with gut dysbiosis.

http://www.ei-resource.org/illness-information/environmental-illnesses/candida-and-gut-dysbiosis/

http://www.holistichelp.net/blog/candida-sibo-or-h-pylori/

If our ammonia levels get high then H Pylori will turn pathogenic to protect itself. When in commensal form it prevents allergies. When H pylori is in pathogenic form it inhibit ghrelin which inhibits digestion and can cause food to sit in the gut and ferment leading to bloating, dybiosis and can inhibit digestive enzymes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888205/

I am not going to cover histamines in this post I will address it in a post on over and under methylators because high and low histamines can cause over or under methylation. Leaky gut, inflammation and status of our immune system can effect methylation.

Now connect this with my other post and you will see that there is no doubt that germ theory and terrain theory are not correct and that our Facebook groups theory “Enveroment and Biome Theory of Health is correct.

Here is a list of my articles on health that will support my case.

Improtance of human photosynthesis in health.

https://iamajuicer.wordpress.com/2018/11/13/importance-of-human-photosynthesis-in-health/

Why so many are experiencing gender identity crisis.

https://iamajuicer.wordpress.com/2018/11/12/why-so-many-are-experiencing-changes-in-gender-identity-why-so-many-children-have-gender-identity-issues/

We can expect diabetes to rise because of all these things.

https://iamajuicer.wordpress.com/2018/07/21/diabetes-type-1-type-2-and-type-3c/

You can use the above mentioned information to help with hypertension.

https://iamajuicer.wordpress.com/2018/10/28/causes-of-hypertension-and-things-that-may-help/

https://iamajuicer.wordpress.com/2018/10/24/the-truth-about-heart-disease-cholesterol-lowering-drugsand-their-effects-on-mental-health-and-health-of-the-body/

https://iamajuicer.wordpress.com/2018/07/25/carditis-hypertension-tachycardia-and-many-other-cardiovascular-disease-all-have-a-common-tie-and-common-solution/

Compare the above mentioned things and the things that occur within the body and you can make the connection to the gut. This list the many things that can go wrong and how to use nutrients to help heal.

https://iamajuicer.wordpress.com/2018/10/12/my-summarized-notes/

Even allopathic medicine is contributing to the chronic illness and the poor health of modern day society so they are the bad environmental part.

https://iamajuicer.wordpress.com/2018/10/08/cause-of-flaccid-myelitis/

Even our brain gets effected.

https://iamajuicer.wordpress.com/2018/10/02/cant-sleep-feel-disassociated-could-be-your-pineal-gland/

https://iamajuicer.wordpress.com/2018/09/21/things-linked-to-alzheimers-and-chronic-illness/

https://iamajuicer.wordpress.com/2018/07/11/hyper-excitement-of-nmda-autism-also-known-as-encephalitis/

We are taught that things like genetics are inherited but it is our eating habits and microbiome that gets inherited and they are things that can be changed. Even asthma we are taught is inherited but I have seen many in my life correct it and live a normal life and never suffer from it again.

https://iamajuicer.wordpress.com/2018/09/22/causes-of-obesity-and-things-that-may-help/

https://iamajuicer.wordpress.com/2018/09/20/why-asthma-is-rampant-now/

We are told that our genes are written and cannot be changed but science is finding that is not true.

https://iamajuicer.wordpress.com/2018/09/02/1303/

Stomach problems they claim runs in families but it is actually the gut microbiome they inherited and can be corrected.

https://iamajuicer.wordpress.com/2018/09/02/the-microbes-that-help-heal-the-gut/

https://iamajuicer.wordpress.com/2018/08/21/things-that-may-help-those-who-have-the-more-difficult-digestive-problems/

Many have problems with lipid metabolism now days. They claim it is inherited genetics but when I ask people if anyone else in there family suffered from it they say no. So how can it can they inherit something no one else ever experienced in their families?

https://iamajuicer.wordpress.com/2018/08/21/things-that-may-help-with-lysosomals-storage-disease/

The above mentioned things should help with liver disease also.

https://iamajuicer.wordpress.com/2018/08/14/fatty-liver-cirrohsis-thrombosis-and-other-diseases-caused-by-fibrosis/

Many things like COPD are set off by infection or toxins. By now you should know that most supposed pathogens actually help the body unless we have too many toxins or we are lacking a nutrient.

https://iamajuicer.wordpress.com/2018/07/20/things-that-may-help-with-copd/

This is why cancer is so rampant. Cancer is pretty much caused by man and the environment men have created.

https://iamajuicer.wordpress.com/2018/07/29/cancer-what-causes-it-what-may-help-with-it/

https://iamajuicer.wordpress.com/2018/07/22/what-they-dont-want-you-to-know-about-cancer-and-why-so-many-children-are-getting-it/

Our enviroment and biome can effect our health by causing excess oxidative stress.

https://iamajuicer.wordpress.com/2018/08/02/oxidative-stress-the-antioxidant-systems-and-how-they-effect-our-health/

Now you can see why tick born illness is rampant. Thing that usually would not usually effect man is now causing illness. Infection indicates there is a nutrient deficiency or enviromental toxin or enviromental biome issue. Something is out of balance. Man is viewing symptoms like cancer, diabetes, and mental illness as the cause and they are symptoms of underlying problem.

https://iamajuicer.wordpress.com/2018/06/17/vaccinations-spread-and-cause-disease/

https://iamajuicer.wordpress.com/2018/10/08/cause-of-flaccid-myelitis/

https://iamajuicer.wordpress.com/2018/07/21/things-they-would-rather-you-did-not-know-about-lyme/

Vaccination are one of the biggest contributors of modern illness.

https://iamajuicer.wordpress.com/2018/07/13/identifying-vaccine-injury-and-its-cost-to-society/

This is why detoxing is so important now days. Even our food has become toxic. Organic helps reduce the impact of mans destruction of our environment and the human and planetary biome.

https://iamajuicer.wordpress.com/2018/07/14/detoxing-we-need-it-now-days/

https://iamajuicer.wordpress.com/2018/07/23/how-toxic-is-your-food/

https://iamajuicer.wordpress.com/2018/06/17/genetically-modified-foods-destroy-our-health-glyphaste-and-glufonisate-add-to-the-toxicity/

They know their science is fake so they use every tactic they can to hide that fact.

https://iamajuicer.wordpress.com/2018/08/11/tactics-used-by-corporate-science-to-deceive-people-into-no-asking-questions/

If you have read this then by now it have figured out it is not your genes but your enviroment, inner and outer biome and not your genes that effect your health.

https://iamajuicer.wordpress.com/2018/06/27/its-not-your-genes-it-is-your-gut-microbiome/

Histamine homeostasis is very important in fighting chronic illness.

https://iamajuicer.wordpress.com/2018/07/12/the-effect-of-high-or-low-histamines/

Since modern day illness is causing chronic illness by destroying our gut we need to work on restoring it to heal. Leaky gut causes endotoxemia. I listed in the microbe list above which ones reduce endotoxins. It also causes high oxalates so you will have to work on reducing them.

https://iamajuicer.wordpress.com/2018/06/28/leaky-gut-oxalates-and-more-supplement-information/

https://iamajuicer.wordpress.com/2018/07/08/dealing-with-endotoxemia-or-sepsis/

All these things are types of autoimmunity and we need to restore our immune system back to homeostasis.

https://iamajuicer.wordpress.com/2018/07/15/autoimmunity-what-causes-it-and-things-that-may-correct-it/

Interstitial cystitis and vaginitis are some of the worst autoimmune disorders to deal with because our modern day environment makes it difficult to acheive homeostasis in the areas effected.

https://iamajuicer.wordpress.com/2018/07/15/causes-of-vaginitis-thinning-or-atrophy-of-the-vaginal-walls-and-things-that-may-help/

https://iamajuicer.wordpress.com/2018/06/18/healing-interstitial-cystitis/

 

Constipation can lead to inflammatory bowel disease and inhibited bile productin and  is caused by an imbalance in our gut microbiome. It can lead to chronic illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951383/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872693/

I noticed that those with dysbiosis had issues when the consumed or took tryptophan. This study suggest that SERT might be upregulated in dysbiosis which wold explain why tryptophan made them worse. Sert is the serotonin transporter.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583244/

https://www.nature.com/articles/s41598-017-10835-8

There are those who say but things like H Pylori cause illness. So how could that prove what your are saying. H Pylori just like many of our beneficial bacteria only cause problems when something has changed to cause it to occur. They say yeah but there is strains that are pathogenic and strains that are not. Well the biggest part of the population is believe to have the supposed pathogenic strain of H Pylori. So you have to ask why doesn’t everyone get gastric ulcers?

https://www.frontiersin.org/…/10…/fmicb.2018.00609/full

Even our good gut bacteria can cause illness if we have digestive problems.

https://www.sciencedirect.com/science/article/pii/S1198743X14618838

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490230/

Our food and water is so toxic now it has a negative impact on our guts. The crazy thing is some of these toxins are found in vaccines so imagine what they are doing when they are being directly shot into peoples blood streams.

https://www.mdpi.com/2076-2607/6/2/53/htm

Desulfibrio species digest sulfur which produces H2S. If H2S levels get too high it can cause many health issues. B Thetamiomicron free sulfur which feeds Desulfibrio species. They cannot free it themselves. Mercury and lead increase Desulfibrio species. Excess H2S can lead to constipation. This is why high levels of Akkermansia and Desulfibrio results in inflammatory bowel diseases, gall stones and many other diesease. Not getting enough fermentable carbohydrates increases sulfur digesting microbes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1233901/

https://www.ncbi.nlm.nih.gov/pubmed/26491870

https://www.ncbi.nlm.nih.gov/pubmed/19709217

https://www.tandfonline.com/doi/abs/10.3109/00016357.2013.770163

https://www.frontiersin.org/articles/10.3389/fmed.2017.00163/full

It is listed among the bacteria that increases the risk of heart disease and diabetes.

https://www.ncbi.nlm.nih.gov/pubmed/29800124

Glycomacropeptide found in whey protein and fermentable fiber reduces sulfur digesting bacteria. Fermentable fibers are pectin, Beta-glucan found in mushrooms and oatmeal, guar gum, inulin and oligosaccharides. If a person is not used to getting them they will have to ease into them. Until the body is used to getting them they will cause bloating and gas. As the body gets used to them the symptoms will slowly decrease. Psyllium should be avoided it has been found to make the symptoms worse.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593820/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190755/

Those with inflammatory bowel and gut dysbiosis usually have high levels of H2S being produced by their gut microbes. Fructooligosaccharide and Resistant starch decreases H2S but psyllium increases it so psyllium should be avoided.

https://www.ncbi.nlm.nih.gov/pubmed/29561196?fbclid=IwAR3wOZijtOeO0NF_4liAPIZwHwiK-bAqMn4IsPFQNQ1PbkuJU0cydwzuFs0

Strange lactulose is in raw milk increases Hydrogen production but it helped me.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201941/

Now we do not want to completely rid ourselves of the H2S producing microbes because they are needed to keep us health. We want to try and restore homeostasis. For those with high sulfur digesting bacteria a glass of non sulfur wine may help.

https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.855.3

High H2S levels can effect sulfation by inhibiting sulfur detoxification. It can even effect the antioxidant system. High H2S levels also inhibits nNOS. It can be countered by increasing NADPH and BH4.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040266/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210431/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599001/

Methane producing bacteria can also cause constipation leading to inflammatory bowel diseases. Those with high methane levels usually suffer from nausea, will feel full and bloated, may experiencing vomiting. They will have milk intolerance because the sugars in milk feed methane producing bacteria. They will experience bouts of severe depression. Constipation causes bile to become inhibited resulting in similar health problems as those who have high sulfur digesting bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987281/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544731/

For those with dysbiosis from high methane producing bacteria should not drink alcohol it can make it worse.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544731/

Those with methane producing dysbiosis need to avoid fermentable carbohydrates and lactulose found in milk products. I know those feed the good gut bacteria but they also feed the gut bacteria that produce hydrogen which feeds the methane producing bacteria.

https://bellalindemann.com/treat-constipation-causing-methane-sibo/

Methane producing bacteria out compete Sulfur digesting bacteria for H2 unless sulfate is present.

https://gut.bmj.com/content/32/12/1498

This surprised me the same microbes that feed the sulfur digesting bacteria also feed the methane producing bacteria. Firmicutes and bacteroides is high in both types of dysbiois.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC442992/

This is another commonality that I have found with those who have inflammatory bowel from too many sulfur digesting and too many methane producing is they both had low bacteroides fragilis levels. I am cautious recommending this because if level get too high it can cause health problems.

https://www.hindawi.com/journals/bmri/2016/5828959/

Bacteroides vulgatis and Bacteroides Dorei are usually low in both types of inflammatory bowel and can lead to cardiovascular disease. Seems there is an easy fix for this. Eating walnuts. This should help Both types of inflammatory bowel issues.

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.033714

https://www.fasebj.org/doi/abs/10.1096/fasebj.29.1_supplement.1006.1

Excessive methane production or excessive hydrogen production can cause malabsorption. So both should be measured in those with malabsorption issues.

http://iopscience.iop.org/article/10.1088/1752-7155/7/2/024001/meta

Alcohol consumption should be avoided with methane producers because it increases methane.

https://www.nature.com/articles/s41598-017-07637-3

The gut microbes are dramatically different in those with NAFLD.

When you look at studies on cirrhosis of the liver. The things that help NAFLD seem to be things that improve oxidation which leads me to believe they are low oxidizers. But alcohol liver disease seems more inflammatory. But they both have links to the gut. Very interesting report.

https://www.mdpi.com/2072-6643/10/10/1457

If a person craves sugar it may mean their lactobacillus acidophilus levels are too high.

Microbes interact with our mitochondria including our gut microbes.

https://academic.oup.com/femspd/article-pdf/74/1/ftv096/10749982/ftv096.pdf

Chemicals in our environment and those pushed by the pharmaceutical industry change our external environment which is killing the commencile pathogens that keep the pathogenic ones in check. This is a common theme now days. When someone gets and infection they either have high toxin levels, were taking allopathic medications or had a nutrient deficiency. All those effect our commensals that protect us from their pathogenic cousins.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510460/

Some functional food that help straighten the gut out.

https://www.frontiersin.org/articles/10.3389/fmicb.2017.02146/full

https://www.frontiersin.org/articles/10.3389/fvets.2018.00166/full

 

Probiotics and their effects on autoimmune disease.

https://www.mdpi.com/2072-6643/10/10/1537/htm

And yes autoimmunity can lead to mental illness that is why vaccine damage the brain.

https://onlinelibrary.wiley.com/doi/full/10.1111/imm.12943

Using the information on probiotics above you can see the connection between the gut and arthritis.

https://www.mdpi.com/1422-0067/19/9/2508

Those with Trimethylaminuria may be deficient in sulfur digesting bacteria. This would reduce TMAO in the plasma. Could Trimethylaminuria be from a deficiency in methane producing and enterobacteriaceae?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4239492/

https://www.nature.com/articles/ismej201772

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-018-0461-0

How microbes effect neurological stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736941/

This report shows why it is important to address leaky gut and gut dysbiosis. It can damage the kidneys.

https://www.mdpi.com/2072-6651/10/7/300

Methylation issues must be addressed before you can get your gut to heal.

Overmethylators

http://www.mensahmedical.com/common-symptoms-of-overmethylation/

Undermethylators.

http://www.mensahmedical.com/common-symptoms-of-undermethylation/

IL-22 is needed to protect us from pathogens and to stimulate FUT2. If we are deficient in certain gut microbiota that stimulate FUT2. We will have immune issues and gut dysbiosis because FUT2 keeps our good gut microbes health.

http://www.traceyreed.ca/blog/2016/4/12/fut2s-role-in-gut-healths-role-in-gut-health

https://www.sciencedirect.com/science/article/pii/S0022283615006051

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774895/

ILC3 is needed for our gut microbiome to communicate with the body to increase FUT2. ILC3 is secreted by our gut microbiome.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774895/

http://science.sciencemag.org/content/345/6202/1254009.long

https://www.researchgate.net/publication/260808789_Microbiota-Dependent_Crosstalk_Between_Macrophages_and_ILC3_Promotes_Intestinal_Homeostasis/download

Oligosaccharide helps if someone is deficient in FUT2

https://nutritionfacts.org/2013/01/10/boosting-gut-flora-without-probiotics/

https://www.newhope.com/ingredients/oligosaccharides-revealing-more-health-benefits

If the immune system is out of balance IL-22 can be upregulated causing illness. This is why the microbiome that increase T regulatory cell and decrease inflammation are important and reducing endotoxins is also important.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710696/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117408/

https://www.dovepress.com/profile-of-interleukin-22-in-gut-mucosal-health-and-disease-peer-reviewed-fulltext-article-IJICMR

https://www.sciencedirect.com/science/article/pii/S0925443914001513

IBS with constipations is IBS-C, IBS with diarrhea is IBS-D, IBS that is mixed is IBS-M. Most I have met have IBS-C and it is why I post on constipation a lot.

5-HT(serotonin) helps regulate gut motility.

https://www.ncbi.nlm.nih.gov/pubmed/25954931

Lactobacillus Rhamnosus GG increases 5-HT uptake .This would help those who have diarrhea but will decrease motility adding to the problem for those who have constipation type inflammatory bowel. 5-HT plasma levels in those who have diarrhea is low and in those who have consipation it is high. E Coli Nissle 1917 increases 5-HT bioavailibility. F Prausnitzi A2-165 down regualates 5-HT which may help those with constipation type inflammatory bowel. Some of the studies were done poorly but there is useful information in them. They also list some microbiota that can improve motility.

https://www.wjgnet.com/1007-9327/full/v24/i3/338.htm

https://www.wjgnet.com/1007-9327/full/v22/i36/8137.htm

https://www.ncbi.nlm.nih.gov/pubmed/28871143

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583244/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951383/

There are three forms of IBS. IBS-D involves diarrhea, IBD-C involves constipation and IBD-M is a mix of both. Serotonin regulates gut motility and enzyme secretion. Damage to the digestive system and leaky Gut effects GLP-1’s ability to sense nutrients. 5-HT is involved in the regulation of gut motility and enzymes. It depends on GLP-1 and serotonin. Gut our gut bacteria regulate serotonin and GLP-1. The type of microbes involved in the dysbiosis determines which type of IBS a person will suffer from.

https://www.sciencedirect.com/science/article/pii/S2212877818301406

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263172/

Healing the brain and addressing high zonulin levels and restoring the gut bacteria and addressing neurological issues are necessary to restore proper gut brain communication. Inflammation must also be addressed.

https://www.frontiersin.org/articles/10.3389/fnins.2018.00049/full

http://www.mdpi.com/1424-8247/11/3/63/pdf

How metabolic issues disrupt the communication with our gut.

http://jem.rupress.org/content/213/10/2129

Our genes communicate with our gut bacteria.

http://jem.rupress.org/content/215/8/1965.long

http://cancerres.aacrjournals.org/content/77/8/1783

Our genes can be altered by our environment and what we put in them.

https://iamajuicer.wordpress.com/2018/09/02/1303/

A good article on the immune system and our gut.

https://www.karger.com/Article/FullText/484687

 

 

The microbes that help heal the gut.

 

This is not medical advice I am posting this for informational and educational purposes.

Most with inflammatory bowel disease have too many bacteriodes which is caused by excess meat consumption, antibiotics, glyphosate, glufosinate and other farm chemicals. This results in nutrient deficiencies which lead to metabolic and gene problems. Before you can get your gut bacteria reestablished you have to address those health issues because our gut microbes communicate with and modulate our genes. These are the bacteria that was found to help restore intestinal health in those with inflammatory bowel disease or leaky gut. They also help those with autoimmune issues and chronic illness.

Studies have shown that by alternating probiotics and taking lower doses of them and taking a break from them to leave them balance out is more effective at establishing a balance of our gut bacteria.

Each of our triggers are different so it is important to keep a food diary on how various food effects you.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021001/

Our gut bacteria modulate our genes. So an imbalance in them or a deficiency has effects on our genes,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915727/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892391/

We need a diversity in our gut bacteria for them to stay established.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107516/

A loss of short chain fatty acid and butyrate producing bacteria cause inflammatory bowel disease and constipation.

https://jcm.asm.org/content/52/2/398

Our diets influence out gut bacteria for example meat alkalizes the gut producing an environment that will permit the rise of certain bacteria that can lead to health problems. If we consume too much meat it can lead to inflammatory bowel diseases because it raises bacteroides levels and kills the bacteria that produce the good fats we need and the short chain fatty acids the body needs. High bacteroides levels can also lead to heart disease, diabetes, and even autoimmunity. Also a diet high in meat can increase the bacteria in our guts that cause inflammation.

Transfats and oils like vegetable oil and canola oil were found to raise bacteroides levels and decrease our good short chain fatty acid producing bacteria. Oils like olive oil, coconut oil and fish oil have been found to promote good gut bacteria.

Whey protein and the glycoproteins found in mushrooms have been found to reduce bacteroides and increase the good gut bacteria.

Lactose has been found to increase the good bacteria that helps produce butyrate and short chain fatty acids. This is why it is important to address lactose intolerance, it can be corrected.

Sugar increases Bifidobacterium, this could be bad for those who are over weight but good for those who are under weight and need to gain weight.

Prebiotics like resistant starch, oligosaccharides, fructosaccharides increase our short chain fatty acid producing bacteria. Short chain fatty acids are very important keeping us healthy. They have also been found to increase the microbes that protect and strengthen the health of our digestive system.

Polyphenols found in fruit especially berries, promote good bacteria while reducing the bad.

Artificial sweeteners especially aspartame has been shown to increase bacteroides to the point it could lead to irritable bowel syndrome.

https://www.hyperbiotics.com/blogs/recent-articles/89735302-your-diet-changes-your-microbiome-fast

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1175-y

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417592/

A list of foods that increase our good gut bacteria.

https://cfsremission.com/2017/08/24/food-to-increase-bifidobacteria-and-lactobacillus/

In order to establish our good bacteria we need FOMAPs I found introducing them very slowly worked best for me as my gut bacteria received the food they needed and increased I could increase my FODMAP intake. If we stay on a FODMAP diet too long it will make it difficult to reestablish our good bacteria. Adjust the diet to your body do not stick strictly to diet but base it on how your body responds. I used a paleo diet after the FODMAP but did not stick to either diet strictly but based them on how my body responded.

https://gut.bmj.com/content/gutjnl/64/1/93.full.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830546/

paleo diet.

http://paleozonenutrition.com/2018/02/21/autoimmune-paleo-protocol-in-inflammatory-bowel-disease-clinical-study-shows-remission-in-73/

Akkermana Muciniphila It is found in the upper part of the intestines and helps regulate bile acid production. Bile acids help regulate our pancreatic enzymes so indirectly it also regulates our digestive enzymes. It is believe to restore the mucous membrane in the digestive system. Polyphenols from berries helps to feed it and increase it’s numbers. Oligosaccharides also increase A Muciniphila. It has been found to be low in those with obesity. A deficiency in A Muciniphila will cause a deficiency in short chain fatty acids and inhibited lipogenesis. A person deficient in A Muciniphila will develop insulin resistance and low glucose levels.

https://ubiome.com/blog/post/akkermansiamuciniphila/

http://www.mdpi.com/2076-2607/6/3/75

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614963/

Oligosaccharides and inulan have been shown to increase A. Muciniphila. This is why green algae and seaweed have so many health benefits they are high in oligosaccharides.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983298/

https://www.sciencedirect.com/science/article/pii/S1756464617301627

https://gut.bmj.com/content/67/2/271.long

Roseburia species help produce butyric acid, short chain fatty acid and protects us from diabetes and obesity. They help prevent inflammatory bowel disease. Beta Glucan in mushrooms and oats , chitan and inulin help raise Roseburia levels. Butyric acid protects the gut and our brains. It also protects our nerves and is important in the absorption of nutrient. If we are deficient in butyrate we will not absorb nutrients. Butter and ghee are good sources of butyrate until the gut bacteria are restored.

https://www.futuremedicine.com/doi/abs/10.2217/fmb-2016-0130?src=recsys&journalCode=fmb

https://gut.bmj.com/content/63/8/1275.long

https://academic.oup.com/femsec/article/87/1/30/508741

Faecalibacterium Prautsnitzii increases IL-10, this is important because Lyme and other illnesses that carry the OspA protein inhibit IL-10 to stealth themselves from the bodies immune defense. There isn’t much known about it except that it is low in many types of digestive disorders. We get it from being around others who have it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705805/

https://www.nature.com/articles/ismej2016176

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492426/

Clostridium Butyricum is a butyrate producing bacteria . Clostridum butyricum kills it’s cousin that cause negative health effects. It also increases IL-10 . It also decreases inflammatory cytokines. There are studies that have shown if the other healthy gut bacteria are not present this one like many of the bacteria species used in probiotics could start causing health problems.

https://www.ncbi.nlm.nih.gov/pubmed/30159141

https://www.ncbi.nlm.nih.gov/pubmed/30141701

https://www.ncbi.nlm.nih.gov/pubmed/29851202

It promotes better bowel movements.

https://www.ncbi.nlm.nih.gov/pubmed/30058712

https://academic.oup.com/cid/article/61/7/1107/289593

E Coli Nissle 1977 doesn’t only protect us from it’s cousins that cause ill health effects it also protects against other types of infections. It has been shown to put inflammatory bowel disorders into remission. It has too many benefits to mention. The only way I know of getting this one is through a probiotic called Multaflor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987069/

https://www.tandfonline.com/doi/full/10.3109/08910600903444267

E Coli Nissle 1977’s cousin can cause many health problems if not kept in check.

https://www.physiology.org/doi/10.1152/ajpgi.00091.2016

Lactobacillus Casei and L. Longum have been find to be deficient in many types of digestive disorders. They do not establish well of one or the other is missing it is best if they are taken together if you use a probiotic. The improve the bodies antioxidant capacity. We need SOD to produce H2O2 which the body uses to detox cells and transport nutrients and enzyme into and out of the cells. When deficient in these cellular macrophagy is inhibited. This help protect against cancer and other illnesses.

If we are deficient in them we can develop liver disease, lysosomal storage disorders and glycogen storage issues, insulin resistance and lose the ability to absorb nutrients. Our blood sugar levels will become low because insulin levels will increase. Bifidobacterium Bifidum has many of the same benefits and probably would benefit from taking it along with these. Also we cannot absorb proteins without the Lactobacillus strains.

https://www.hindawi.com/journals/omcl/2016/1340903/

https://www.ncbi.nlm.nih.gov/pubmed/30158369

They also help protect us from mold toxins.

https://www.frontiersin.org/articles/10.3389/fmicb.2018.01503/full

http://pubs.rsc.org/en/Content/ArticleLanding/2018/FO/C8FO00252E#!divAbstract

Lactobacillus Longum also produces folate for us.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654071/

protects our lungs.

https://www.ncbi.nlm.nih.gov/pubmed/30020533

https://www.ncbi.nlm.nih.gov/pubmed/24830455

Insulin and glycogen issues.

http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2016;volume=7;issue=1;spage=102;epage=102;aulast=Sharma;type=3

Protein absorption.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741550/

A species of bacteria called lactobacillus casei shiroto is important in regulating our tryptophan levels. A deficiency in this strain will cause reduce tryptophan levels resulting in anxiety and the inability to sleep. A deficiency in this one can result in phenylketonuria which causes high ammonia levels in the body. A person who has this issues will get ill when they eat meat , potatoes or other things high in phenylalanine. Low levels of tryptophan can cause a loss of the beneficial bacteria in the Roseburia family which can lead to leaky gut and inflammatory bowel disease and sever constipation.

https://aem.asm.org/content/82/12/3649

https://www.researchgate.net/publication/287309677_Lactobacillus_casei_Shirota_modulation_of_ammonia_metabolism_in_physical_exercise

Fermented milk like butter milk and kefir help them get established.

https://www.jstage.jst.go.jp/article/fstr/10/2/10_2_143/_article

Many have been found to be deficient in Streptococcus Salivarius protects us from lung, oral and nasal infections. It also protects us from inflammation. Those who are deficient in S Salivarius will be prone to infection especially from it’s cousins in the streptococcus family that cause negative health effects. The only way I know to safely increase this is with lozenges that contain it because too much can cause health problems so you would want to avoid taking capsules of this.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911234/

https://www.futuremedicine.com/doi/abs/10.2217/fmb.12.113?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=fmb

https://www.nature.com/articles/s41598-017-11446-z

Lactobacillus Rhamnosus helps prevent diarrhea , has been shown to reduce symptoms of inflammatory bowel disease. It helps protect us from infection. Helps protect us from allergies,obesity and diabetes. It also helps protect us from staph infection.

H Pylori is commensal but without Lactobacillus Rhamnosus to keep it in check it can cause gastric ulcers.

https://www.selfhacked.com/blog/l-rhamnosus/

https://aem.asm.org/content/80/18/5773

https://www.frontiersin.org/articles/10.3389/fmicb.2018.01873/full

We also need fungus for example Saccharomyces Cerevisiae know as brewers yeast helps prevent diabetes. They used to think S Boulardii was a separate species but it has been found to be the same. I couldn’t afford the supplement so I bout a package of brewers yeast and consumed it. Wasn’t sure it would make it through my stomach acid but I felt improvement so I believe it does. Now this is one you do not want to increase too much, also you do not want to take this if you have autoimmune issues or leaky gut. It can act as a pathogen if it gets into the blood stream, many of our microbiome can if they get too high in numbers or get into our blood stream.

https://www.ncbi.nlm.nih.gov/pubmed/23967428

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705302/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605952/

S Cerevisaiae helps reduce vaginalis and candida.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037478/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354225/

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1574-6968.2010.02037.x

Lactobacillus Rueteri produces folate those who have folate deficiency have been found to be low in folate and have high inflammation levels. L Rueteri also regulates our oxytocin which can give us a feeling of self worth and well being. A deficiency in L Rueteri can lead to extreme depression.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061717/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431580/

Our gut bacteria produce B vitamins for each other and maintain each other. If the ones who produce the B vitamins are missing then the microbiome will get them from our foods which will prevent us from receiving them. This is why it is important to eat foods high in B vitamins and to protect our gut bacteria from antibiotic, farm chemicals and toxins in our foods like artificial sweeteners.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403557/

Lactobacillus Acidophilus prevents diarrhea, helps protect against clostridium infections. Those with interstitial cystitis are usually deficient in this one. It helps reduce symptoms of inflammatory bowel disorder. Acidophilus regulates our ph of our digestive system and bladder and keeps it at the correct ph. Our bladders and digestive system need to be acidic. An akaline environment can cause a loss of our good gut bacteria and promote the growth of the bad. It can also cause candida to go from commensal to a pathogenic form. Many with interstitial cystitis have found relief using L Acidophilus suppositories. Those who are having difficulty gaining weight usually have excess L acidophilus levels because it speeds up metabolism and those who have problems with weight gain are often deficient in acidophilus. Fermented foods are high in this but those with high histamine must reduce their histamine before eating fermented food I addressed that in my autoimmune post.

https://www.healthline.com/nutrition/lactobacillus-acidophilus#section3

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705118/

Bifidobacterium increased the acid levels of our digestive tract which inhibits bad bacteria from growing and help keep our digestive tract acidic. It has been shown to reduce symptoms of irritable bowel disease.

https://www.nature.com/articles/ajg200925

Bifidobacterium Infantis protects us from autoimmune disorders by regulating our T cells. B infantis also helps protect our digestive tract.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277968/

https://www.ncbi.nlm.nih.gov/pubmed/28230606

This is an in depth discussion of probiotics.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424311/

more information on microbiome and folate production.

http://www.mdpi.com/2072-6643/3/1/118

Bifidobacterium Breve reduces symptoms of celiac disease.

https://www.ncbi.nlm.nih.gov/pubmed/26134988

Frequent constipation is a sign of a deficiency in the bifidobacterium species.

https://www.ncbi.nlm.nih.gov/pubmed/28884754

If we are deficient in the lactobacillus species we are more prone to salmonella infection.

https://www.ncbi.nlm.nih.gov/pubmed/29120368

https://www.ncbi.nlm.nih.gov/pubmed/28975642

Lactobacillus Bulgaris increases T Regulatory cells which prevents on over active immune response.

https://www.thieme-connect.com/DOI/DOI?10.1055/s-0043-117612

Too many Lactobacillus Delbrueckii can cause urinary tract infection.

https://jcm.asm.org/content/47/1/275

Our gut microbiome produce many of our nutrients so a deficiency in a specific strain can cause nutrient deficiencies especially in the B vitamins.

https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-017-0691-z

Quinones like PQQ is needed by our gut bacteria to thrive and balance out. They convert it to vitamin K2.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738691/

Phylloquinone (vitamin K) is also used by our gut bacteria and converted to vitamin K2. Animal products and leafy green vegetables are good sources of vitamin K . Many should be cooked especially spinach and kale because they are very high in oxalates.

http://www.jbc.org/content/283/17/11270.full

https://www.medicalnewstoday.com/articles/219867.php

https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/phylloquinone-vitamin-k1-intakes-and-food-sources-in-1864-year-old-irish-adults/00B5ECF7B563D1A3ADAA94986FC83223

Some food sources of quinones are. Natto, Green Tea, Parsley, Paypaya and green peppers. Some may benefit from supplementing PQQ because many of the foods that contain it are very high oxalate like kiwi.

https://biofoundations.org/dietary-sources-of-pyrroloquinolone-quinone-pqq/

https://optinghealth.com/foods-high-in-pqq/

Soil based probiotics have been shown to improve digestive health.

Bacillus Subtilis produces and antibiotic that protects us but is none toxic to the good bacteria. B Subtilis has antioxidant properties. B Subtilis has been shown to restore normal gut flora. B Subtilis has been shown to relieve constipation and diarrhea. It has reduce symptoms of inflammatory bowel disease. It boost immunity and fights H Pylori. It improves the health of the liver. It promotes the production of digestive enzymes which improves gut health.

https://www.ncbi.nlm.nih.gov/pubmed/21204933

https://www.selfhacked.com/blog/b-subtilis/

https://www.globalhealingcenter.com/natural-health/bacillus-subtilis-probiotic-strain/

Bacillus Coagulans improves insulan sensitivity. High insulin levels are common in inflammatory bowel disease, this would help reduce insulin levels. It helps reduce diabetes symptoms. B Coagulans improves muscle recovery and prevent arthritis. It helps increase the beneficial microbes in the gut. It relieves intestinal pain inflammation and constipation. B coagulans reduces the risk of urinary tract infections.

https://www.selfhacked.com/blog/b-coagulans/

https://www.verywellhealth.com/bacillus-coagulans-for-better-bowel-health-89601

Bacillus Clausii protects us from respiratory infection. It fights the infections that cause diarrhea. It reduces symptoms of inflammatory bowel disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1936284/

https://www.omicsonline.org/open-access/bacillus-clausii–the-probiotic-of-choice-in-the-treatment-of-diarrhoea-2157-7595-1000211.php?aid=63792

Two soil based probiotics to watch out for because they can cause major health problems are bacillus Licheniforms and Enteroccocus Faecium.

Those with inflammatory bowel disorders have high bacteroides. They produce high levels of Beta Glucuronidase. This inhibits glucuronidation which is needed to detox mold toxins.

https://blog.healthmatters.io/2018/08/24/what-is-beta-glucuronidase/

http://www.pjm.microbiology.pl/archive/vol6232013319.pdf

Things that may help those who have the more difficult digestive problems.

This is not medical advice I am posting this for informational and educational purposes.

If you truly want to heal it takes time and persistence. You have to develop your own protocol there is no one size fits all your protocol must be unique to you and your health problems. There is no magic bullet, pharmaceuticals treat the symptoms not the cause. So you may feel better but will slowly get worse until you will start needing other medications to hide the new symptoms that arise from the declining health which pharmaceuticals contribute to.

It takes a lot of research and patients. Take notes of what works and what does not and keep readjusting your protocol. As you heal your protocols will need to change.  Homeostasis is the goal once you start feeling better try cutting supplements out. If it goes well then take a maintenance dose of the supplement once in a while.

Mucilage every few hours helps a lot with leaky gut. When you have leaky gut it causes high oxalate levels. This causes a cycle that is hard to break because oxalates prevent the gut from healing. Mucilage can help heal the gut breaking the cycle. Mucilage helped me the most with healing my gut.

Things that are high in mucilage are Okra, organic Oatmeal, Aloe Vera I found the liquid gel worked the best dried aloe vera seemed ineffective. Besella Alba known as Malabar Spinach, Irish moss but you have to watch consuming it, it has a cannabinoid that reduces pain but has side effects if you consume too much. Most plants in the mallow family are very high in mucilage and have very good healing properties. Most plants in the dioscera family are high in mucilage especially the chinese wild yam. Fenugreek is high in mucilage. Flax seeds are high mucilage but if you have leaky gut they should be ground up to prevent other heath issues. Most seaweeds are high in mucilage. Licorice root is high mucilage but you have to make sure it is deglycyrrhizinated if not it can cause many health problems. Mullein is high mucilage and helps with lung infections. Most edible plants in the daisy and sunflower family are high in mucilage. Wild Daisy helped me a lot. Pysillium seed husk are high in mucilage they are seeds from the plantain herb. Plantain herb itself is very high in mucilage. Wild violet is very high in mucilage. Chia seed is high in mucilage most seed is. Slippery Elm is high in mucilage but some claim it is high oxalate , I have never tried it. Most roots herbs are high in mucilage. Arrow root is very high in mucilage.

https://mavcure.com/mucilaginous-herbs/

https://www.invitehealth.com/article-demulcents-and-mucilages-true-healers.html

Various gut microbiome and what they do.

https://www.vitamodularis.org/articles/how_to_interpret_your_microbiome_data.shtml

https://biofoundations.org/increasing-and-maintaining-akkermansia-muciniphila-for-a-healthy-gut-microbiome/

Oregano oil kills just about all pathongens in the gut.

https://www.bmj.com/content/352/bmj.i939/rr-1

Sage also is effective against bad gut bacteria.

http://www.scielo.br/scielo.php?pid=S0034-89102004000200025&script=sci_arttext&tlng=en

Verbana fights Citrobacter. I don’t know much about it but it has sedative effects and helps with seizures.

https://www.cogentoa.com/article/10.1080/23312009.2017.1363342.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5174135/

Beta Glucuronidase is low it can effect hormones. If it is high it can cause toxins reabsorption.

https://biofoundations.org/maintaining-a-proper-balance-of-beta-glucuronidase-for-disease-and-cancer-prevention/

High beta glucuronidase causes high estrogen.

https://www.planetnaturopath.com/hormones/high-beta-glucuronidase-and-how-it-affects-estrogen-and-detoxification/

Herbs that strengthen the immune system.

http://www.chiro.org/nutrition/FULL/Bacteria_That_Strengthen.shtml

We also need to reduce oxidative stress and nitrositive stress.

https://iamajuicer.wordpress.com/2018/08/02/oxidative-stress-the-antioxidant-systems-and-how-they-effect-our-health/

https://iamajuicer.wordpress.com/2018/07/11/nitrosative-stress/

Streptoccocus bacteria produce an exotoxins streptolysin and NAG -glycohydrolase which help it evade the immune system.

Inhibiting NLRP3 helps resolve the issues Streptolysin causes. It uses a tactic similar to Lyme disease it stimulates inflammation to evade the immune system.

https://www.frontiersin.org/articles/10.3389/fcimb.2018.00211/full

Rabdosia contains oridonin which inhibits NLRP3.

https://www.nature.com/articles/s41467-018-04947-6

There are a number of ways being used to inhibit NLRP3 inflammasome.

https://www.frontiersin.org/articles/10.3389/fphar.2015.00262/full

Resveratrol, quercetin and curcumin are NLRP3 inhibitors.

https://www.hindawi.com/journals/mi/2016/5460302/

Paeonia is a CBR2 activator which inhibits NLRP3.

https://www.ncbi.nlm.nih.gov/pubmed/25854559

CB2R receptor activation protects and heals the nerves.

https://www.nature.com/articles/cddis2014364

Hypoxia reduces NLRP3 and induces autophagy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524634/

https://www.tandfonline.com/doi/full/10.4161/auto.22783

bacillus subtillus kills most bad gut bacteria.

https://aac.asm.org/content/59/11/6844.full

https://www.tandfonline.com/doi/full/10.4161/viru.29514

https://www.sciencedirect.com/science/article/pii/S0168160511007136?via%3Dihub

We need butyrate producing bacteria to protect from inflammation. Also it protect the brain.

https://gut.bmj.com/content/63/8/1275.long

Fodmap diet helps with IBS.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555627/

Increasing Treg through FOXP3 cells helps.

https://www.hindawi.com/journals/jdr/2013/621693/

https://www.ndcn.ox.ac.uk/publications/692350

Our gut bacteria regualate T Reg cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276397/

https://ctajournal.biomedcentral.com/articles/10.1186/s13601-016-0108-9

Mycobacteria can inhibit NOD2 which can cause gut issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316803/

Infection can lead to NOD2 deficiency this causes a reduction in V-ATPase which is needed to produce stomach acid.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316803/

https://www.ncbi.nlm.nih.gov/pubmed/25335775

https://www.frontiersin.org/articles/10.3389/fimmu.2016.00367/full

Over stimulation of NOD2 can also make us prone to infections and chronic illness. Homeostasis should be the goal.

https://www.nature.com/articles/srep08383

https://www.spandidos-publications.com/10.3892/etm.2017.4288

https://www.kidney-international.org/article/S0085-2538(15)55943-7/pdf

HSP70 Restores NOD2 function. I have posted on HSP70

https://pubs.acs.org/doi/abs/10.1021/acs.biochem.7b00470?src=recsys&journalCode=bichaw

http://www.jbc.org/content/289/27/18987.long

Our diet and many probiotic strains can induce HSP70 which will restore NOD2 function which would restore dendric cell funtion.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892289/

Trypterygium Wilfordii may help restore NOD2 function though this is a single case report.

https://journals.lww.com/md-journal/fulltext/2017/11270/Case_report___remarkable_remission_of_SAPHO.114.aspx

Our diet and our gut interactions.

https://www.frontiersin.org/articles/10.3389/fimmu.2016.00290/full

Sulfation is involved in hormone production and use. Gut dysbiosis, glyphosate, mercury and other toxins can inhibit sulfation. This can result in hormone dysregulations. This can also result in high DHEA levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016456/

https://www.ncbi.nlm.nih.gov/pubmed/28153960

https://www.ncbi.nlm.nih.gov/pubmed/30087535

To much hydrogen sulfide producing bacteria lead to chronic illness.

https://www.physiology.org/doi/pdf/10.1152/physrev.00017.2011

https://pdfs.semanticscholar.org/1fda/f6c18c0b184ae8e41c8a777b2979bedd2494.pdf

Too many methane producing bacteria can lead to constipation there are some probiotics that will help with that.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609747/

http://www.talkingaboutthescience.com/studies/Donohue-Sulfoxidation.pdf

The craziest part of all of this is I seen supposed pathogens that could correct many of these issues but did not include them in this but they turn certain genes of which could restore the function of non-functioning genes.

Diets effect on gut bacteria.

https://www.aivpa.it/files/upload/rivista_articolo/00152_microbioma-dieta-disturbi-gastroenterici-e-disbiosi.pdf

https://watermark.silverchair.com/fux022.pdf?

http://www.drwallyschmitt.com/Newsletters/issue-43-molybdenum/

http://www.drmyhill.co.uk/wiki/Fermentation_in_the_gut_and_CFS

Tributyrin found in butter helps with dysbiosis

https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.994.9

https://biofoundations.org/multiple-health-benefits-tributyrin-triglyceride-form-butyrate/

Sulfur regulation in the body is very improtant.

https://www.mthfrsupport.com.au/wp-content/uploads/2017/04/PPT-CBS-Pathway-Final-full-page-slides.pdf

Dysbiosis often leads to impaired renal function.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431124/

Those who have gut issues will be deficient in short chain fatty acids and they are very important in maintaining our health.

https://biofoundations.org/multiple-health-benefits-tributyrin-triglyceride-form-butyrate/

Many will have high oxalate levels which are produced endogenously. I have posted on oxalates. This can prevent the gut from healing.

https://mthfrsupport.com/2018/03/understanding-sulfation-and-oxalate/

http://www.lowoxalate.info/research.html

https://people.csail.mit.edu/seneff/DC2016/CynthiaSmith_DC2016.pptx

Autophagy corrects lipid metablolism which is needed to produce bile and digestive enzymes. Bile homeostasis is very important for the health of the whole body.

http://jem.rupress.org/content/early/2018/01/12/jem.20171965.long

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930069/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247383/

Hydrogen peroxide is needed for lipogenesis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5369955/

https://www.sciencedirect.com/science/article/pii/S0014579300021979

SOD increases H2O2. The only bioavialable source in food is the chaga mushroom.

https://jonbarron.org/herbal-library/nutraceuticals/superoxide-dismutase

http://www.worthington-biochem.com/sodbe/default.html

Curcumin increase SOD but should not be taken too long it chelates iron and can cause anemia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705117/

http://www.raysahelian.com/superoxidedismutase.html

http://www.foodtrients.com/inside/sod-do-you-know-about-this-powerful-antioxidant/

Sidt2 deficiency can inhibit autophagy. Unfortunately I have not research this Gene much.

https://www.ncbi.nlm.nih.gov/pubmed/29363559

Though I do not believe in taking enzymes the body can produce if all else fails what else are we to do. Often times taking enzymes the body can produce can disable the bodies ability to produce them.

https://empoweredsustenance.com/fat-malabsorption/

Increasing brush oder enzymes helps with malabsorption.

https://www.ncbi.nlm.nih.gov/pubmed/11346204

You must heal the endothelium to correct malabsorption. Saccharomeyces Boulardii is needed for that. This also improve lipid abosorption.

https://www.ncbi.nlm.nih.gov/pubmed/29762474

https://metabolichealing.com/villous-atrophy-leaky-gut-intestinal-dysbiosis/

Dietary nucleotide supplementation helps heal the digestive tract.

https://www.sciencedaily.com/releases/2014/04/140416143313.htm

https://www.selfhacked.com/blog/dietary-nucleotides-health-benefits-of-nucleotides/

https://www.researchgate.net/publication/275771517_Nucleotides_supplementation_improves_various_function_of_the_body

https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1440-1754.2002.00056.x

Mucins and tight junctions regulate what passes in and out of the intestines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548832/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095905/

High zonulin levels causes the gut to become more permeable.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458511/

High zonulin levels has been linked to many diseases.

https://www.mygenefood.com/zonulin-leaky-gut/

https://www.jillcarnahan.com/2013/07/14/zonulin-leaky-gut/

Probiotics to reduce zonulin.

https://www.realnatural.org/probiotics-help-reduce-intestinal-permeability-also-called-leaky-gut-syndrome/

colostrum reduces zonulin.

https://www.researchgate.net/publication/316676047_Oral_Supplementation_with_Bovine_Colostrum_Decreases_Intestinal_Permeability_and_Stool_Concentrations_of_Zonulin_in_Athletes

https://www.naturalnewsblogs.com/healing-leaky-gut/

Brush border enzymes are needed to break down and absorb food.

http://www.vivo.colostate.edu/hbooks/pathphys/digestion/smallgut/bbenzymes.html

https://www.core3training.com/can-improve-gut-overall-health/

Black Seed Oil improves carbohydrate digestion.

https://www.ncbi.nlm.nih.gov/pubmed/28959553

Thyme improves brush border enzymes.

https://www.ncbi.nlm.nih.gov/pubmed/29223554

How bile is secreted.

https://www.ncbi.nlm.nih.gov/pubmed/29262229

http://www.sophiahi.com/how-to-increase-your-digestive-fire-by-jeannie-oliver-chc-cpt/

Foods that contain natural digestive enzymes.

https://www.healthline.com/nutrition/natural-digestive-enzymes#section2

They mention Kiwi in this one. It is high oxalate so would not be good for someone who has leaky gut.

https://starmystuff.com/top-7-foods-contain-natural-digestive-enzymes

 

I am sorry these are things I forgot to post with this post. It is concerning restoring the ability to produce short chain fatty acids.

Diasccharidase in involved in our digestion and absorption of carbohydrates and sugars. If we are not producing enough then our food will sit and ferment in our upper intestine possibly feeling like a brick is sitting in our stomaches. This will cause excess gas and can lead to the production of hydroxl sulfide which inhibits sulfation and can cause issues with the CBS and BH4 pathways. This can lead to high ammonia levels, proteinuria, phenyketonuria and even porphria. Infection can cause this, an imbalance in our gut bacteria brought on by farm chemicals especially glyphosate, antibiotics, and even chemicals found in processed food. If you have diarrhea and you are not absorbing then you may be producing too much disaccaride which is an indication of high insulin levels. High oxalates will prevent the gut from healing. I have posted on oxalates and the gut. If we produce too much diasaccaride then we will experience similar symptoms only instead of being constipated we would have diarrhea.

https://drhoustonanderson.com/disaccharidase-deficiency-causes-and-treatment/

Vinegar seemed to help me but this studies shows it actually reduces Disaccharidase. Not sure what to think about this one.

https://academic.oup.com/jn/article/130/3/507/4686196

We know those with IBD usually have high insulin levels showing they have lost their sensitivity to insulin. This leads to high leptin levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159716/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959465/

I know those with IBD connot do some of these things. You have to learn to figure out what in the information that is out there you can apply and what you cannot.

https://www.healthline.com/nutrition/improve-insulin-sensitivity#section8

Though being insulin resistant is usually found in obesity it is common in many inflammatory bowel disorders.

Increasing insulin sensitivity will help with leptin levels.

https://www.marksdailyapple.com/25-ways-to-improve-your-insulin-sensitivity/

https://www.selfhacked.com/blog/top-tips-for-fixing-insulin-resistance/

Increased insulin levels inhibits disaccharidase levels.

https://www.ncbi.nlm.nih.gov/pubmed/21946084

Decreased insulin levels increases disaccharide levels.

http://www2.ufpel.edu.br/biotecnologia/gbiotec/site/content/paginadoprofessor/uploadsprofessor/8aff603648377229ebdb3b655ecdf854.pdf

Now if you look at MAPK it is involved in IBD. So now we can see the connections. We need to increase insulin sensitivity . I read many research articles and decreasing insulin levels seem to make IBD worse but improving insulin sensitivity improved IBD. Inhibiting TNF-a improves insulin sensitivity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792822/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859792/

There are naturals that inhibit TNF-a but nothing that inhibits it directly. Also inhibiting it for too long makes us more prone to infection.

https://www.researchgate.net/profile/Solomon_Habtemariam/publication/12454244_Natural_Inhibitors_of_Tumour_Necrosis_Factor-a_Production_Secretion_and_Function/links/09e4150bb180eefd74000000/Natural-Inhibitors-of-Tumour-Necrosis-Factor-a-Production-Secretion-and-Function.pdf?origin=publication_detail

Resvertrol inhibits TNF-a it is found in grape seed extract.

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091406

Reducing insulin levels reduces P38 MAPK which reduces symptoms of IBD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218950/

Those who have IBD have been found to be deficient in bacteria in the up digestive track especially Oscillospira and Akkermansia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573342/

https://helda.helsinki.fi/bitstream/handle/10138/236401/Akkermansia_muciniphila.pdf?sequence=1

Lactobacillus Fermentan increases Akkermansia.

https://www.ncbi.nlm.nih.gov/pubmed/28935567

Host microbe prebiotic and fiber interactions. Interesting lets you know how each type of saccharide effects the gut bacteria.

https://www.tandfonline.com/doi/full/10.1080/19490976.2017.1290756?src=recsys

Studies confuse me, some says stay away from carbohydrates will others show that those carbs increase the very bacteria those who have IBD are deficient in.

https://academic.oup.com/jcem/article/101/1/233/2806797

Beta Glucan found in Oats and mushrooms increases Oscillospira.

https://www.frontiersin.org/articles/10.3389/fmicb.2017.00966/full

Meditarrian diet can increase Oscillospira.

https://www.ncbi.nlm.nih.gov/pubmed/26505825

L-arginine has been found in many studies to help normalize the gut bacteria even in chickens.

https://www.ncbi.nlm.nih.gov/pubmed/28901890

Nanosilver can kill specific gut bacteria depending on the size and shape. In theory this could be used to reduce specific gut bacteria that may be too numerous.

https://www.researchgate.net/publication/241100111_Comparison_of_the_anti-bacterial_activity_on_the_nanosilver_shapes_Nanoparticles_nanorods_and_nanoplates

The shape of the silver determines which bacteria it is effective against.

https://www.ncbi.nlm.nih.gov/pubmed/28588204

Glutamine reduces Oscillospira which would be detrimental to IBS.

https://cfsremission.com/2017/10/15/decreasing-oscillospira-genus/

Black Raspberries increase Oscillospira.

https://www.ncbi.nlm.nih.gov/pubmed/29502392

Most with IBD are difficient in Oscillopira. This is found in the upper digestive tract. I believe it is the cause of the low disaccharidase production but I cannot find studies to prove it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437018/

A deficiency in Oscillopira causes food allergies.

Food additives have a negative impact on the gut.

https://www.ncbi.nlm.nih.gov/pubmed/29914144

This is a good list of bacteria and what they do. Bifidobacteria Bifidum and Breve increase short chain fatty acid production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964481/

Our gut bacteria regulate cell that produce antibiotics.

https://www.frontiersin.org/articles/10.3389/fmicb.2018.00736/full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801817/

More on Oscillopora.

https://www.datapunk.net/substrata/display.pl?119852+S

Bile acid also increases Oscillopora.

https://onlinelibrary.wiley.com/doi/abs/10.1111/1758-2229.12319

https://drjockers.com/25-ways-improve-gallbladder-health/

Gut homeostasis is controlled by the endocannbinoid system. Those with inflammatory bowel issues have been found to have low endocannbinoids. This raises diaglycerols which can prevent the proper production of digestive enzymes leading to the inability to digest and absorb saccharides and produce short chain fatty acids (carbohydrates and sugar). This is caused by the upregulation of the protein kinase pathway.

https://www.ncbi.nlm.nih.gov/pubmed/22917662

Black pepper increases endocannbinoids which would help with IBD.

https://www.ncbi.nlm.nih.gov/pubmed/24412246

HSP70 is a transport for anamide and other endocannabinoids. I have posted on HSP70.

FAAH inibitors increase endocannabinoids.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882713/

Biochanin A found in read clover, the red covering on peanuts, and in chick peas is an FAAH inhibitor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931556/

Here is information on other cannabinoids and their effects on the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429335/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538700/

Kaempferol found in pine tree bark extract and magnolia is an FAAH inhibitor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2538700/

Bilirubin is inhibited with IBD and other inflammatory bile diseases. This is cause by the inflammation which can lead to scarring and obstruction of biliary ducts. Serrapeptase helps remove scar tissue and so doe HSP70. Also using anti-inflammatory herbs helps.

http://www.crohnscolitisfoundation.org/resources/liver-disease-and-ibd.html

https://inflammatoryboweldisease.net/symptoms/complications/gallstones/

https://kresserinstitute.com/little-known-connection-leaky-gut-gluten-intolerance-gallbladder-problems/

This is the oddest part about IBD and other inflammatory diseases. TMAO is low in those who have an intestinal inflammatory disease. Most have too much of the bacteria that produces TMAO but those with IBD have too few.

https://www.ncbi.nlm.nih.gov/pubmed/26160437

This is a list of gut bacteria that increase TMAO consuming choline will increase these bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4453578/

https://lpi.oregonstate.edu/mic/other-nutrients/choline

https://draxe.com/what-is-choline/

Faecalibacterium Prausnitzii has been found to be low in those with inflammatory bowel disease. This causes a dificiency in nicotinic acid which leads to an increase in phenylalamine. This lead to a conditions called phenyketonuria which causes high ammonia levels in the body and can effect many metabolic pathways and cause us to become ill when we eat meat, potatoes or anything else that has phenylalanine in it. A deficiency in Faicalibacterium Prausnitzii also results in high cadaverine and putrescine levels which causes inflammation.

https://emedicine.medscape.com/article/945180-overview?pa=70SvUf61EZjJeh01GcM07cjK0CdaeXT%2FVguJkgES6Vuf4MsXKJuI2VMwKp69ZMinm%2BKlpX80V6KaHMrB8SW%2FFlaycSibeA0Q%2FJsWK%2BpGHzs%3D

https://www.healthline.com/health/phenylketonuria

Our gut bacteria need iron tho thrive but the iron they fortify food with is the wrong type. Iron found in curly dock and burdock root will supply you with iron without causing toxicity unless you have certain liver diseases. If you have iron toxicity lactoferrin will restore iron homeostasis. Curcumine will reduce iron levels in the blood also but do not take it too long or you can become anemic.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5491036/

Ghrelin stimulates our appetite and increase stomach acid.

https://www.theunion.com/news/twi/glyphosate-roundup-and-its-link-to-celiac-disease-gluten-intolerance/

Fatty acid and vagus nerve stimulate ghrelin.

https://academic.oup.com/abbs/article/41/3/188/655

https://www.ncbi.nlm.nih.gov/pubmed/29632576

https://www.selfhacked.com/blog/32-ways-to-stimulate-your-vagus-nerve-and-all-you-need-to-know-about-it/

https://thelivingproofinstitute.com/19-ways-to-stimulate-your-vagus-nerve/

https://www.psychologytoday.com/us/blog/the-athletes-way/201607/vagus-nerve-stimulation-dramatically-reduces-inflammation

I had to alternate types of diets until I got things straightened out. I had to do a FODMAP diet first then as I healed I had to switch to a Paleo diet. Then when I had healed enough I was able to fast it took me a while to build up to being able to fast for a day. Some can go longer and it is dangerous for others like those with lysosomal storage issues.

https://paleoleap.com/butyrate-anti-inflammatory-fat/

Hydrogen Sulfide produced by gut bacteria can cause sulfation issues.

https://sibosurvivor.com/hydrogen-sulfide-sibo/

When we have too much hydrogen sulfide being produce by our gut microbiome it will cause us to become constipated.

 https://www.ncbi.nlm.nih.gov/pubmed/28971603

https://www.sciencedirect.com/science/article/pii/S2213007117300485

now you have reached a state that has caused a cycle that is hard to break and results in ulcerative coalititis and even IBS.

 https://link.springer.com/article/10.1023/A:1018867516575

Excess H2S causes low blood pressure and a reduced body temperature. It will slow our metabolism causing us to feel drowsy.

http://www.ei-resource.org/…/gut-bacteria-the-hydrogen…/

The inhibited phosphorylation causes a deficiency in the redox ions needed by many metabloic pathways. Mainly Mg2+, Mn2+, Zn2+ and indirectly Ca2+. So it pretty much shuts cellular function down.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010430/

Not all will get drowsy with the inhibited phosphorylation it may cause NMDA issues which is what happened to me. When this happens and your glutamate levels sky rocket it will fell like your head is going to spit open, you will not be able to sleep and you will experience anxiety.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966912/

This thread is long enough but the can effect the CBS and BH4 pathways which can lead to sulfur intolerance and meat intolerance. Even after correcting this problem you have to heal the gut and get the oxalates down to restore the function of the metabolic pathways.

http://www.talkingaboutthescience.com/studies/Donohue-Sulfoxidation.pdf

Having to many H2S producing bacteria has been shown to raise blood levels of H2S. I could not find studies on the prolonged effects but I have found information on prolonged exposure. It causes sulfhemoglobin which cannot be broken down by the body.

http://www.theijoem.com/ijoem/index.php/ijoem/article/view/482

https://www.ncbi.nlm.nih.gov/pubmed/25237136

https://www.frontiersin.org/articles/10.3389/fped.2018.00098/full

Thiamine and B6 deficiency can cause high oxalates.

https://www.ncbi.nlm.nih.gov/pubmed/3947375

https://draxe.com/thiamine-foods/

the gut and cholestokinin

http://www.yourhormones.info/hormones/cholecystokinin/

https://www.selfhacked.com/blog/good-bad-effects-cck/

Trypsin inhibitors increase cholecystokinin.

https://naldc.nal.usda.gov/download/26115/PDF

Things that raise GABA like , mugwort, wormwood and rooibos reduces cholecystokinin levels. High estrogen levels cause high cholecystokinin levels. High dopamine levels increases cholecystokinin. High levels of cholecystokinin causes glutamate toxicity and NMDA toxicity.

https://www.acnp.org/g4/GN401000056/CH056.html

Potatoes increase cholecystokinin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033477/

If not addressed it leads to autism.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628252/

Proprionate is high in Ibs. This strikes me as odd because acetate and butyrate are low in IBS. How can one short chain fatty acid be high and the test dificient?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847229/

https://www.healthline.com/nutrition/short-chain-fatty-acids-101#section1

High proprionate can cause loss of appetite and weight loss.

https://gut.bmj.com/content/64/11/1744

it is from having to high of bacteroides.

https://jb.asm.org/content/jb/134/1/84.full.pdf

This article partially explains the high bacteroides levels.

http://humanfoodproject.com/going-feral-one-year-journey-acquire-healthiest-gut-microbiome-world-heard/

Meat increases bacteriodes.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820228/

meat alkalizes the gut so it makes sense that those with IBD may consume more meat which will make them have raised bacteroides levels. This can lead to many health problems.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949257/

Betaine reduces bacteriodes by increasing stomach acid.

https://www.selfhacked.com/blog/tmg-health-benefits/

http://drlwilson.com/articles/TRIMTHYLGLYCINE.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176045/

Snail1 involvement in inflammatory bowel diseases indicates macrophagy issues.

https://www.ncbi.nlm.nih.gov/pubmed/21830269

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0450-z

Macrophagy issue also cause lipogenesis issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108423/

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0450-z

Glycolysis issues are also an indication of inhibited macrophagy and sure enough those with inflammatory bowel disorders have glycolysis issues.

https://onlinelibrary.wiley.com/doi/abs/10.1002/ibd.21388

Macrophagy genes have been impicated in inflammatory bowel disease.

http://www.els.net/WileyCDA/ElsArticle/refId-a0025006.html

Good information from my friend David Anderson.

For people with digestive issues

Hydrophilic colloidal diet

1. Hydrophilic colloids bring about conditions in the stomach during digestion which approach those resulting from the consumption of foods in their natural state.

2.Hydrophilic colloids lessen gastric irritation by absorbing the digestive secretions of the stomach so that digestion takes place within a mass of food.

3. Gelatin, because of its availability, relatively low cost, non-toxicity, adaptability as an item of dietary and its thorough digestibility becomes an admirable hydrophilic colloid for dietary usage.

4. The amount of gelatin to be used in a given case depends on the patient’s needs, but it must be of good quality and sufficient in amount.

5. It has a wide range of usefulness in gastrointestinal ailments ranging from the atonic conditions met in the chronic invalid to the irritating condition presented in gastric ulcer.

In some instances, gelatinized arrowroot powder has been used to achieve similar results.. Arrowroot/pectin, etc… Could possibly be used if oxalates are an issue.

 

https://link.springer.com/article/10.1007%2FBF03010602

 

Medium chain triglycerides improve bile flow and decrease bile reabsorption.

https://med.virginia.edu/ginutrition/wp-content/uploads/sites/199/2014/06/Parrish-February-17.pdf

https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-018-0267-x

MCTs help heal leaky gut and inflammatory bowel disorders.

https://www.ncbi.nlm.nih.gov/pubmed/27187452

https://www.frontiersin.org/articles/10.3389/fimmu.2016.00290/full

Organic acids help heal the gut mucosa.

https://www.researchgate.net/profile/Ulker_Eren2/publication/282700134_Effects_of_dietary_organic_acid_supplementation_on_the_intestinal_mucosa_in_broilers/links/5649b1d908ae451880af661a/Effects-of-dietary-organic-acid-supplementation-on-the-intestinal-mucosa-in-broilers.pdf?origin=publication_detail

http://www.mdpi.com/2072-6643/9/9/920/pdf

file:///home/homuser/Downloads/nutrients-09-00920.pdf

They recommend glutamate in this. That is not correct because those with inflammatory bowel issues have high bacteriodes and glutamate feeds them which can make things worse. But there is useful information in this.

There is an error in this. Those with inflammatory bowel have high bacteroides which causes a lot of problems. They claim glutamate helps but it feeds bacteroides so would make things worse but I found useful information in this.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622680/

Interesting information on inflammatory bowel disease.

https://www.hindawi.com/journals/mi/2017/6869259/

Those with inflammatory bowel issues are low in biotin which is probably caused by the inflammation inhibiting absorption.

https://europepmc.org/abstract/med/19056639

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129763/

A biotin deficiency causes the inability to break down proteins, fats and other nutrients.

https://www.physiology.org/doi/abs/10.1152/ajpcell.00141.2016

Those with inflammatory bowel usually have low biotin which can cause many metabolic issues. Biotin needs Adenosylcobalamin which is a form of B12 in the body. Some may have to supplement if the body is not converting it.

Adenosylcobalamin helps with biotin absorption and use.

https://www.globalhealingcenter.com/natural-health/adenosylcobalamin-4-facts-know/

Biotin and pantothenic acid compete for absorption and pantothenic acid can inhibit biotin absorption.

https://www.ncbi.nlm.nih.gov/pubmed/9814986

Alkaline Phosphotase is low in those with inflammatory bowel disorders. Lactobacillus Casei increases it and will help with nutrient absorption.

https://www.ncbi.nlm.nih.gov/pubmed/22783049

Before increasing it make sure you know the dangers of too much.

https://www.selfhacked.com/blog/alkaline-phosphatase/

How to increase ALP.

https://health.onehowto.com/article/how-to-increase-alkaline-phosphatase-11707.html

http://www.newhealthguide.org/Low-Alkaline-Phosphatase.html

If you take curcumin once the gut bacteria start getting established stop taking it. It can cause anemia because it chelates iron.

https://www.ncbi.nlm.nih.gov/pubmed/25474287

Cissus stimulates ALP.

https://www.ncbi.nlm.nih.gov/pubmed/25449449

https://examine.com/supplements/cissus-quadrangularis/

High estrogen levels effect bile production. Bile protects the intestines from inflamation.

https://hormonesbalance.com/articles/gallbladder-hormone-balance-connection-mean-dont-gallbladder/

Hormones involved with bile flow.

https://hormonesbalance.com/articles/gallbladder-hormone-balance-connection-mean-dont-gallbladder/

Inhibited bile flow can cause estrogen dominance.

http://www.jbc.org/content/early/2018/06/21/jbc.RA118.001789.full.pdf

This causes a cycle that is hard to break and results in high cck levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756670/

Activation of the CCK1 receptor by estrogen can lead to gall stones.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037422/

Dim3 (diinoylmethane) inhibits the estrogen receptor which should lower cholestokinin levels.

https://www.ncbi.nlm.nih.gov/pubmed/25486199

http://joe.endocrinology-journals.org/content/195/3/393.full.pdf

Things that inhibit Era.

https://www.hindawi.com/journals/omcl/2018/6040149/

They mentioned soy isoflavons in the previous study but it could make things worse.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633874/

ursolid acid that was mentioned is found in the wax on skins of apples , in rosemary and thyme.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379974/

 

These are enzymes and hormones that are usually dis-regulated in inflammatory bowel.

Cholesterols function in bile secretion. Issues with the liver X receptor can cause issues with cholesterol metabolism.

http://www.jbc.org/content/278/18/15565.long

https://www.ncbi.nlm.nih.gov/pubmed/29523554

Olive Oil help resolve liver X receptor issues. But inhibits glucuronidation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521785/

Butyrate found in butter and ghee also help.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111843/

High estrogen inhibits sulfation. Increasing UDP-glucuronosyltransferases will reduce estrogen levels.

http://www.jbc.org/content/275/46/36164.full.pdf

http://dmd.aspetjournals.org/content/30/5/564

DHA, oleic acid, and linoleic acid inhibit those enzymes.

https://www.nature.com/articles/srep02903

Foods that increase UDP-glucuronosyltransferase.

http://dmd.aspetjournals.org/content/30/5/564

https://www.heart-health-guide.com/apigenin.html

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874462/

https://www.selfhacked.com/blog/apigenin-top-11-science-based-health-benefits-apigenin/

Luteiolin is good at increasing UDP-glucuronosyltransferase.

http://secretsofnaturalhealing.blogspot.com/2010/12/luteolin-rich-foods-shown-to-reduce.html

https://www.selfhacked.com/blog/top-11-science-based-health-benefits-luteolin/

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166239

Diosmetin is found in the white parts of citris fruit and dates.

https://pubs.acs.org/doi/abs/10.1021/jf502359x?src=recsys&journalCode=jafcau

https://www.researchgate.net/publication/228115816_Bioactivity_of_Diosmetin_Glycosides_Isolated_from_the_Epicarp_of_Date_Fruits_Phoenix_dactylifera_on_the_Biochemical_Profile_of_Alloxan_Diabetic_Male_Rats

 

 

 

 

 

Germ Theory and Terrain Theory are wrong.

Terrain theory is wrong and so is germ theory. I will add more links showing this is true as I find them. Our group on Facebook Synergistic Illness has come up with a theory we call “Enviromental Biome Theory of Health. ” . Our environment as a whole effects our health and if you read my post on here on “It is not your genes it is your gut bacteria” or “Vaccines spread disease they do not prevent them” and many other of my post support this theory. The health of our soil is important because if it is healthy then the plants are healthy providing more nutrients. If there are chemicals and toxins in the soil they effect the body and cause us to be susceptible to things making us ill that would normally be beneficial. I covered that in my post
“Things Science has wrong”.

It is our internal and external exposome that determines if we get ill or not. This is why some seem immune to infectious disease while others seem impervious. Medications, toxins in our foods, chemicals used for farming are destroying the external and internal exposome. Studies have shown many supposed infectious agents can play a protective roll in the body so we need to ask ourselves why in some do these supposed infectious agents protect them but make others ill?

In this post i am showing how our gut microbiome regulate our gene expressions and our immune system. They also are responsible for all types of immunity in the body. I posted the links to the other blog post that support this at the bottom of this post.

Bifidobacterium feed each other.

If we was all like Bifidobacterium the world would be a better place.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623478/

How our bodies feed our bacteria.

https://www.frontiersin.org/articles/10.3389/fmicb.2017.00484/full

Inflammation causes a loss of pattern recognitions sensor which is how HIV and cancer become established.

https://www.frontiersin.org/articles/10.3389/fimmu.2014.00367/full

Inflammation can also lead to NAFLD.

http://stke.sciencemag.org/content/sigtrans/10/491/eaal3336.full.pdf

Ketogenic diet restores gut balance.

https://www.nature.com/articles/s41598-018-25190-5/

Importance of being eubiotic

https://www.omicsonline.org/open-access/the-importance-of-being-eubiotic-2329-8901-1000162.php?aid=88559

how our gut bacteria regulate our gene expressions. Too many of some and not enough of others can lead to cancer, autoimmunity, even COPD.

https://www.nature.com/articles/cmi20187

http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1019.4532&rep=rep1&type=pdf

http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005579

https://gutpathogens.biomedcentral.com/articles/10.1186/1757-4749-5-23

Irritable bowel syncrome.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525272/

Our gut microbiome regulate whether we get cancer or not.

https://msystems.asm.org/content/3/3/e00205-17

Our gut bacteria effect whether we are obese and whether we develop heart disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063892/

Metabolic issues and autoimmune issues need to be addressed or our genes cannot communicate with our gut bacteria this can lead to diabetes.

http://jem.rupress.org/content/early/2016/09/07/jem.20160526

Our genes communicate with our gut microbiome.

http://jem.rupress.org/content/215/8/1965.long

http://cancerres.aacrjournals.org/content/77/8/1783

Our gut microbiome prevent bone loss through the production of SCFA.

https://www.nature.com/articles/s41467-017-02490-4

Our gut bacteria regulate our T cells and B cells.

https://www.tandfonline.com/doi/full/10.1080/19490976.2017.1299311

https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.febslet.2014.04.007

T cells turn genes on and off making us susceptible to illness if there is an imbalance.

https://www.nature.com/articles/ncomms4551

When you read the following studies you will see the connection with this one and how our gut help develop humoral immunity.

https://www.ncbi.nlm.nih.gov/pubmed/27760339

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916850/

Our microbiome regulate our T cells so it is a microbiome cycle of communication.

http://www.pnas.org/content/114/21/5497.long

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080902/

IgA is needed for our gut microbiome to become established.

https://authors.library.caltech.edu/85463/

http://science.sciencemag.org/content/360/6390/795.long

Now if you read this study you will see that our gut microbiome regulate our immune system. It is a cycle so we need diversity. Now there are many things that can disrupt this cycle. T cells are needed to keep this cycle going and there are many things that can cause a T cell imbalance.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451207/

Certain strains of bacteria can restore IgA production.

https://www.nature.com/articles/s41598-018-23404-4

Our diet effects our gut bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787545/

Resveratrol helps restore MyD88 function.

https://www.ncbi.nlm.nih.gov/pubmed/30107238

MyD88 is needed to fight pathogens. It causes an immune response by causing inflammation.

http://www.jbc.org/content/280/32/29242.full

The Nrf2 pathway is needed to prevent excess inflammation from MyD88 activation. Blocked Nrf2 will cause excess inflammation.

https://www.sciencedirect.com/science/article/pii/S0006291X10021108

https://www.cell.com/cell-reports/abstract/S2211-1247(15)00802-5

IL-10 prevents MyD88 from causing exciess inflammation.

http://www.pnas.org/content/106/43/18327.full

Along with our T cells and B cells our gut bacteria also regulate IL-10.

https://www.hindawi.com/journals/jir/2014/586939/

Issue with the retinoic receptor can also inhibit our gut bacterias communication with our cells.

https://www.nature.com/articles/mi2016114

It is important for that communication to keep our body from attacking our good gut bacteria.

https://www.nature.com/articles/nature10434

Those who have an over active immune response would want to avoid TLR2 agonist they increase the immune response and the inflammation. This would help those who have low CD4 counts.

http://www.jimmunol.org/content/jimmunol/186/2/1119.full.pdf

Coriolus mushroom is a TLR2 agonist which would stimulate the immune system.

https://www.ncbi.nlm.nih.gov/pubmed/21068144

Turkey tail mushroom also is a tlr2 agonist.

http://dl.begellhouse.com/journals/708ae68d64b17c52,5c93eb0962bab6ac,34fa1edb20739135.html

Spirulina increases cd4 T cells.

http://www.mdpi.com/2072-6643/6/7/2973

Those with HIV lack the gut bacteria that stimulate CD4 cell production.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891875/

These are things that help with HIV.

http://www.greenmedinfo.com/blog/38-natural-alternatives-hiv

Yogurt increases CD4.

https://insights.ovid.com/pubmed?pmid=20463586

Phloretin is a TLR2 inhibitor. This reduces the immune response and would reduce inflammation.

http://www.mdpi.com/2072-6643/10/7/868

Biacalein is a tlr2 inhibitor.

https://www.hindawi.com/journals/bmri/2012/267890/

We need to keep in mind that our immune system protects us from cancer so loss of MyD88 can lead to cancer.

https://www.sciencedirect.com/science/article/pii/S0304383518304440

Inhibiting mTOR restores MyD88 this would help with inflammation and HIV.

http://www.jimmunol.org/content/187/11/6052

MyD88 is needed to fight infection but if it is over stimulated it can cause health problems.

http://www.pnas.org/content/111/10/3799.full

So what could cause these cytokine storms that will not shut down. Well vaccines have been well documented for causing such reactions.

https://www.researchgate.net/publication/7105965_The_TLR4_agonist_monophosphoryl_lipid_A_attenuates_the_cytokine_storm_associated_with_respiratory_syncytial_virus_vaccine-enhanced_disease

Over active MyD88 can lead to cancer, lupus and other autoimmune diseases , in autoimmunity TLR are up-regulated which activates MyD88 causing a cytokine storm. If you look at the studies below then look at documented vaccine injury cases you will see they are connected.

http://jem.rupress.org/content/212/13/2184

http://www.pnas.org/content/110/35/E3311.long

https://link.springer.com/article/10.1007%2Fs12016-013-8402-y

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708030/

http://www.bloodjournal.org/content/101/9/3495?sso-checked=true

The harmfull effects of pesticides and herbicides to the gut have been well documented.

http://www.mdpi.com/1099-4300/15/4/1416

https://www.sciencedirect.com/science/article/pii/S0041008X13000549

this is a good article explaining how toxins effect our gut. I have posted on things that effect the gut bacteria. Now we know that they regulate our immune system and many of our genes anything that effects our gut bacteria including dyregulation in B cells or T cells causes a loss of communication with our gut bacteria leading to chronic illness.

https://iamajuicer.wordpress.com/2018/07/16/modern-medicine-is-not-based-on-science/

https://iamajuicer.wordpress.com/2018/07/19/synergistic-illness/

https://iamajuicer.wordpress.com/2018/06/27/its-not-your-genes-it-is-your-gut-microbiome/

https://iamajuicer.wordpress.com/2018/06/17/vaccinations-spread-and-cause-disease/

https://iamajuicer.wordpress.com/2018/07/23/how-toxic-is-your-food/

Leaky Gut, Oxalates and more supplement information.

Written by Lee Stevenson, sorry I am not the best editor.

This is not medical advice and should not be taken as such. I am posting this for educational and informational purposes. I have a book on Amazon I have published on oxalates. I tried to summarize things to help guide people so they could overcome issues with oxalates. It is my only source of income presently. https://www.amazon.com/dp/B0BMJFMQKF

Avoid GMOs they cause leaky gut and gut dysbiosis. If you do not know about them read my post on them. They and the chemicals used on them cause oxalates which I mention later in this article. They kill our good gut microbes. This is a list of gut microbiota and what conditions they help with.

Mucilage every few hours helps a lot with leaky gut. When you have leaky gut it causes high oxalate levels. This causes a cycle that is hard to break because oxalates prevent the gut from healing. Mucilage can help heal the gut breaking the cycle. Mucilage helped me the most with healing my gut.

Things that are high in mucilage are Okra, organic Oatmeal, Aloe Vera I found the liquid gel worked the best dried aloe vera seemed ineffective. Besella Alba known as Malabar Spinach, Irish moss but you have to watch consuming it, it has a cannabinoid that reduces pain but has side effects if you consume too much. Most plants in the mallow family are very high in mucilage and have very good healing properties. Most plants in the dioscera family are high in mucilage especially the chinese wild yam. Fenugreek is high in mucilage. Flax seeds are high mucilage but if you have leaky gut they should be ground up to prevent other heath issues. Most seaweeds are high in mucilage. Licorice root is high mucilage but you have to make sure it is deglycyrrhizinated if not it can cause many health problems. Mullein is high mucilage and helps with lung infections. Most edible plants in the daisy and sunflower family are high in mucilage. Wild Daisy helped me a lot. Pysillium seed husk are high in mucilage they are seeds from the plantain herb. Plantain herb itself is very high in mucilage. Wild violet is very high in mucilage. Chia seed is high in mucilage most seed is. Slippery Elm is high in mucilage but some claim it is high oxalate , I have never tried it. Most roots herbs are high in mucilage. Arrow root is very high in mucilage.

https://mavcure.com/mucilaginous-herbs/

https://www.invitehealth.com/article-demulcents-and-mucilages-true-healers.html

Probiotic Guide.

https://consumeradvisorguide.org/probiotics-supplement-review/index4.html

Do not get discouraged your gut can heal but it may take time.

https://www.prevention.com/health/a20469183/leaky-gut-syndrome/

If we do not correct it , it can lead to many health problems.

http://www.beyondmthfr.com/category/home-slider/

Leaky gut can lead to food allergies and chronic illness.

https://draxe.com/leaky-gut-test/

If you have been damaged by GMOs or antibiotics and have gut dysbiois and it feels like you have a brick in your gut after you eat, you may not be producing enough intrinsic factor which is needed in order for your body to absorb vitamin B12.  A deficiency in B12 causes many serious health problems. These are some things that may increase intrinsic factor.

http://www.sophiahi.com/how-to-increase-your-digestive-fire-by-jeannie-oliver-chc-cpt/

We need to avoid Omega 6 oils. Most of that comes from corn oil,soy bean oil, vegetable oil, and lard. Most of those are from GMOs also. They will cause inflammation in the body if we get too much.

Probiotics are one of the keys to healing the gut. They should be geared to what health issues we are dealing with.

http://www.myleakygutsyndrome.com/probiotics-for-leaky-gut-how-probiotics-can-heal-your-leaky-gut/

NSAIDs can damage the gut if taken for too long which can lead to many forms of chronic illness.

https://jeffreydachmd.com/2014/06/nsaids-small-bowel-leaky-gut/

Healing Leaky Gut

It is very important to

If you have Lyme there is very little knowledge in the medical community to assist with healing and fighting the disease it and other infections can raise zonulin levels causing leaky gut.. There are a few elite doctors who cared enough to do their own research. This is not medical advice. I am posting this to enable people to find the things they need to research to aid in their own healing. Always let your doctor know if you have any diet changes or you take any supplements. Always listen to your body, because it will tell you what is good for it and what is not. When you make any diet changes, whether it is supplements or food, only make one or two changes at a time so that if you have a reaction you will be able to identify what the cause of the problem is.

When you have leaky gut food particles can get into your blood stream which will raise your histamine levels. Signs of raised histamine levels are burning skin , headaches, confusion, fatigue, muscle spasms, blocked urinary track. The list goes on and on so it is very important to get the gut healed or you cannot fight infection or heal.

Healing the Gut

If you have any digestive problems you must take care of those first. Everything is tied to the digestive tract, even the brain. Problems with digestion can lead to a domino effect leading to trouble with hormones, bladder, liver the cardiovascular system, autoimmune system, and even mental health. If you do not get digestive problems taken care of you are fighting a losing battle whatever else you do.

Primary to getting the gut to heal is avoiding foods containing GMOs. They have been shown to damage the digestive system, among other issues.

If you are fighting an infection or dysbiosis the die off can cause bloating. I had to ease into things so I did not bloat too bad. Many probiotics can cause die off of pathogens and some of the bad gut bacteria which will also cause bloating.

Liquid Aloe Vera — this coats the stomach and helps it heal. It has also been shown to fight Candida and H-Pylori when they have switched from commensal to pathogenic forms. Has been shown to reduce oxalates.

Mucilage helps heal the gut. Some wild plants are high in mucilage like Wild Violets and Dandelion, the roots of Evening Primrose are high in mucilage. Plants in the mallow family are high in mucilage. Marshmallow root has many healing properties. The plants with the highest mucilage content are Spinach Vine, Irish Moss, Wild Yam, Fenugreek, Crushed Flax seed, Kelp, Marshmallow Root, Mullein, Okra, Psylium husk which is from the seeds of plantain herb, chia seeds and Broad Leaf Plantain herb. Some may have oxalates but we cannot avoid oxalates we need to address the issues causing high oxalates. Almost all foods have oxalates, cooking breaks down oxalates. But avoiding oxalates entirely will cause you more health problems then it would cure.

Mastic Gum — coats the stomach and has also been shown to fight many pathogens. This is

dried sap from the mastic tree and can be found in health food stores. Coating the stomachache is very important. I know mucilage can inhibit nutrient absorption but you cannot heal if you do not coat your stomach.

Biofilms

This is a list of things that break biofilms or aid the gut in healing. When the biofilms break up you will defecate mucous for about a month sometimes it will appear as if it is a piece of your intestine. I found that very scary and had to ask people who have went through it what it was. There is no information I could find to explain it. Breaking Biofilms is very important in healing our gut if our gut issues are from an infection..

Propolis — a resin produced by bees, so anyone with allergies to bees should not use this one. It has been shown to bust biofilms, kill many pathogens, and to promote gut healing.

Pepto-Bismol — I kept this on hand for when the aloe vera didn’t seem to help. You have to be careful you can herx from this because bismuth kills many pathogens. Bismuth has been shown to also break up biofilms.

phospholipids (good fats) – omega 3s are the best to use. Oils like grape seed oil, sesame seed oil , olive oil contain omaega 3s. Try avoiding Omega 6 it is needed by the body but if we get too much it can cause inflammation.

Garlic- garlic has many healing properties along with breaking up biofilms a killing pathogens. If you have high sulfite levels from having too many sulfur digesting bacteria this will make you ill because it is high sulfur and will raise your sulfite levels. I had this problem but one of the most potent chemicals in garlic is allicin and it does not cause issues with sulfites. I used it and it worked very well for me.

Stevia- it has to be Stevia extract because it needs the cofactors to work. Make sure you get organic because there is GMO Stevia. It also kills many pathogens including Lyme.

Xylitol-has very potent antibiotic properties. Many get cramps when they use it. I got cramps but I had an infected tooth and it worked very well for taking the infection out.

Cinnamon – breaks biofilms, high in mucilage coats the stomachache and helps with nausea. It has been shown to inhibit pain.

Cholesterol breaks biofilms is needed by almost all cells in the body. The brain and heart cannot function without it. Oxidative stress from leaky gut can cause high oxLDL. If you avoid cholesterol because of that you will be inhibiting your bodies ability to heal. When you reduce the source of the oxidative stress your oxLDL will return to normal. Cholesterol is an antioxidant and is used by the body to protect cells from pathogens. Cholesterol is needed to maintain the integrity of the digestive system and bladder.

Chlorophyll – fights Candida, helps remove toxins such as heavy metals from the body, and improves the health of our blood, as well as to protect the good bacteria. Sources of chlorophyll include green leafy vegetables and seaweed, but make sure the seaweed has come from a non-contaminated source. You can purchase liquid chlorophyll. I only used it for about a week and then I backed off to three times a week. There are many health benefits to liquid chlorophyll. It raises oxygen levels in the blood and restores the ph of our bladder and digestive system. It fights many pathogens. It feeds the good gut bacteria while reducing the bad. Those with SIBO will bloat when using this and herx from the die off of the sulfur digesting and methane producing bacteria. If you have SIBO and are going to use chlorophyll I would ease into using it. Liquid chlorophyll also raises oxygen levels in the body and helps restore the health of our blood cells.

Apple cider vinegar – helps fight Candida, breaks up biofilms and kills pain better then aspiron.

Mushrooms — bust biofilms, kill Candida, and fight many other diseases. Most mushrooms will do this. Mushrooms also contain glycoproteins which improve the bodies cell to cell communication so you can heal quicker. Glycoproteins also kill many pathogens so you could herx from them. Mushrooms also contain Beta Glucan which helps restore the good gut bacteria and fights pathogens.

Coconut oil — breaks biofilms and kills pathogens. It can even cross the blood brain barrier and improves brain health. The body converts coconut oil’s lauric acid to monolauren, which has been shown to fight many pathogens, reduce the number of Lyme spyrochetes in Lyme sufferers, and also crosses the blood brain barrier to contribute to improved brain health. Coconut oil contains many of the electrolytes needed by the body. When ill you need more electrolytes then usual.

Bromelain – breaks up biofilms helps fight pathogens , helps with digestion and reduces ammonia in the body.

Flax seed oil — breaks biofilms and fights pathogens. It has Omega-3 fatty acids which help protect the digestive system. Do not use too much flax seed and alternate the days you take it. Taking too much seems to cancel out its health benefits. Also has a canibinoid similar to thc so it reduces pain.

Inulin — promotes healthy bacteria in the digestive system, aiding in the break down and absorption of nutrients. Some sources of inulin are onions, garlic, bananas, dandelion root, chicory root, Jerusalem artichoke, asparagus, barley.

Oxalates.

Symptoms of high oxalates is joint pain, mental fog, anxiety , depression, kidney and liver pain, muscle fatigue, digestive pain, bladder pain, vulvodynia, indigestion when foods containing oxalates are consumed, and skin rashes. Many things can cause oxalates. Metabolic issues, leaky gut, high histamines, gut dysbiosis which cause there to be too many sulfur digesting and methane producing bacteria, which cause high sulfite level and high hydroxy radical levels which result in oxidative stress which also causes oxalates. Toxins such as glyphosate, glufosinate and many other farm chemicals. Also heavy metals, endotoxins, and alfoxins can cause oxalates to form. 

https://www.greatplainslaboratory.com/articles-1/2015/11/13/oxalates-control-is-a-major-new-factor-in-autism-therapy

http://www.lowoxalate.info/research.html

http://bioindividualnutrition.com/oxalates-their-influence-on-chronic-disease/

Oxalates break down when cooked so foods that are high in oxalates like spinach make sure you cook before eating. We cannot avoid oxalates they are in most food.

Oxalates prevent the body from healing and also hinder the gut from healing. That becomes a viscous cycle because when you have leaky gut you will develop high histamines and toxins can easily enter the blood stream, those also cause oxalates. Endotoxins and Afloxin can also cause oxalates. So it is very important to detox. Also metablolic issues and high sulfite levels can cause high oxalates so those should be addressed before detoxing. High sulfite levels can be caused from having too many sulfur digesting bacteria (gut dysbiosis). That in itself will cause many health issues like high ammonia levels. You can heal the gut with high oxalate levels but you must consume a lot of high mucilage foods to coat and protect the gut.

Here is a list of some things that reduce oxalates. I will post some links to some information also. 

https://chriskresser.com/how-to-prevent-kidney-stones-naturally/

http://www.beyondmthfr.com/oxalates-and-mthfr-understanding-the-gut-kidney-axis/

Oxalates cause inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807999/

We have gut bacteria that breaks down oxalates. If we are deficient in them it will raise our oxalate levels. They need the other friendly gut microbiome to establish. If we are lacking in the other gut bacteria they will not establish when we take them. They require an oligosaccharide to get established and remain in the gut. The also need sugar the type found in fruit , honey, or maple syrup will help them establish.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235702/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300851/

Oxalobacter Formingene

Bififobacterium Adolescentis

Bifidobacteriium Anamalis

Lactobacillus Acidophilus

Lactobacillus Gasseri

Lactobacillus Rhamnosus

Lactobacillus Planatarum

Enterococcus Faecalis reduces oxalates but consuming to much salt inhibits it’s ability to degrade oxalates.

Make sure you drink plenty of water. It needs to be free of chlorine or flouride because they cause oxalates and are very toxic to the body.

Avoid artificial sweeteners and processed sugar they can cause oxalates.

Sodium bicarbonate- be careful do not use more then a tablespoon in a glass of water it is a very strong base which means in high amounts it can cause burns. I only took it about 3 times a week.

Citric Acid which is not vitamin C helps reduce oxalates. Lemon juice is a good source of citric acid. It irritated my gut if I used it straight so I put it in my water with a little honey.

Do not take calcium get it from natural sources , calcium reduces oxalates but the calcium found in many supplements is the wrong type and can cause oxalates. Stinging nettles is one of the best sources of calcium. Most foods contain adequate amounts of calcium. If someone has bone loss it is usually from a magnesium or silica deficiency.

Excess salt causes oxalates. I use sea salt. Studies have found using sea salt cuts the craving for salt because of the trace minerals it contains.

Magnesium Citrate reduces oxalates. Also there are many metabolic pathways that need magnesium. When they do not have the nutrients they need oxalates can be produced.

Phytic acid found in grains can cause oxalates. We need phytic acid but should limit our intake of grains.

Foods that raise histamines like fermented foods, aged meats and some cheeses, also yogurt. High histamine levels can cause oxalates.

Vitamin B6 reduces oxalates, I had to use P5P because I wasn’t converting B6/

Vitamin E reduces oxalates. Most seeds contain vitamin E. If you eat flax seeds they have to be crushed or you will not digest them. Avocados are high in vitamin E. Also Olive oil is high in vitamin E. Mango and hazel nuts .

NAC N-Acetyl Cysteine reduces oxalates.

https://www.tandfonline.com/doi/abs/10.1080/10715762.2016.1221507?journalCode=ifra20

Aloe Vera has been shown to reduce oxalates.

Thiamine deficiency can cause high oxalates.

https://alobar.livejournal.com/2510679.html

Do not take more then 4000 IU of vitamin D it can cause oxaltes in very high doses.

https://www.ncbi.nlm.nih.gov/pubmed/8382134

Vitamin D in the correct amounts actually reduces oxalalates. There is a saying the poison is in the dose. I often find that to be true.

https://www.ncbi.nlm.nih.gov/pubmed/19734276

The flavonoids found in the white part of citrus fruits will reduce oxalates.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616898/

Eating too much meat can cause oxalates to form. mainly in those with metabolic issues.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1455427/

Spirulina reduces oxalates but some with high sulfite levels may have trouble with it. I can take it now but it did make me worse because it is high in sulfur.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972226/

http://redmountainclinic.com/the-down-side-to-high-oxalates-problems-with-sulfate-b6-gut-and-methylation/

We need vitamin C to heal. Ester-C has been shown to actually reduce oxalates and can usually be taken by those with interstitial cystitis.

If you have excess oxidative stress it can cause oxalates to form so it must be addressed.

Molybdenum helps reduce ammonia which can cause oxidative stress. Do not take too much it can be toxic if it get to high in our bodies. Many metabolic pathways need it but we do not want to overload on it.

Oxidative stress and oxalates.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4788594/

Diet changes

https://www.rebootwithjoe.com/oxalates-kidney-stones-what-you-should-know/

Sulfation and oxalates.

http://www.beyondmthfr.com/side-high-oxalates-problems-sulfate-b6-gut-methylation/

Herbs for Healing

salsify, and burdock root. Some people are allergic to foods that contain inulin. Most foods that contain fiber that is hard to digest will help balance and protect the good gut bacteria. The allergic reaction is most likely a herx reaction and not an allergic reaction.

Acanthus Ilicifolius – increases production of osteoblast which are necessary for bone growth and health. Has been shown to help gastric ulcers heal. Has strong antibacterial and antifungal properties.

Embilia Ribes (False Black Pepper) — helps with flatulence, kills parasites, decreases homocysteine levels, and reduces symptoms of brain disorders. Lowering homocysteine levels would help with allergies and mast cell activation syndrome.

Pectin — breaks biofilms and lowers bad cholesterol. Pectin is a type of fiber. Food sources include apricots, peaches, apples, bananas, oranges, grapes, carrots, tomatoes and white potatoes.

Phospholipids — protect the digestive system, promote healing, and protect against cancer and infections. Some sources of phospholipids are butter, ghee, and mercury-free fish oil.

Butyric acid — protects our digestive system from infection, protects the body from cancer, aids in breaking food down into smaller particles that are easier for our bodies to absorb and make use of the nutrients. Butyric acid is produced when we consume hard to digest fiber, such as that in celery. It can also be found in ghee and butter.Also some of our microbiome produce this from fiber we consume.

Clove oil — has been shown to fight many pathogens and settles your stomach. This one really helped me because I was having trouble eating due to the nausea from my leaky gut.

Restoring Gut bacteria.

Probiotics — help restore the good bacteria to our digestive system, fight pathogens, and break down our foods. Choose a probiotic supplement with Bifidus and active Acidophilus cultures – the higher the number of cultures the better. The important gut bacteria to get is B Lactis , L Acidophilus, L Rhamnosus , L Salivarius, L Plantarum , B Animalis, B Longus, B Brevi, B Infantis.

Avoid things that contain Lactobaccilus Casei, L Lactis, L Reuteri, L Fermentum/Fermenti, L Paracaei, L Faecum , L Bulgaricus, Streptococcus Thermophilus.

If you start feeling bloated you may be getting to many good gut bacteria which can cause harm also. Get lots of prebiotics it feeds and protects the good gut bacteria and balances it out. Happy gut bacteria will help protect your immune system and help rebuild it.

Fireweed – Helps normalize gut flora, supports the good gut bacteria. Reduces inflammation and symptoms of irritable bowel syndrome. High in mucilage which heals the gut.

Bone broth — helps leaky gut and has the added benefit of containing many nutrients. If you have high sulfite levels or sufation issues you will need to address them before using this. It is high in glutamate and those issues can cause high glutamate levels which will cause very bad headaches and brain fog.

L-Glutamine — helps heal the soft tissue in the gut and is involved in many metabolic processes, fueling white blood cells and many other cells. Unfortunately, animal flesh is the best source of L-glutamine. I say unfortunately because if you have methylation problems digesting meat may be difficult for you. Whey protein and other dairy products are high in L-glutamine, as are eggs, nuts, seeds, lentils and other legumes, but all contain phenylalanine, which can also create problems if you are not methylating right.

I take betaine (trimethylglycine), derived from beets, to aid with the methylation. It has helped me I now rarely get ill when eating things that contain phenylalanine. Bromelain and papaya enzymes are also supposed to help with methylation. Cabbage is a good source of L-glutamine. If you have a blocked or upregualted CBS pathway , or an upregulated BH4 pathway and don’t address it this could make you ill. Most with those issues would benefit from taking P5P, selenium, and magnesium citrate. Also three times a week molybdenum and manganese.

If the pathways for using phenylalanine is blocked then foods high in phenylalanine will raise your ammonia levels and histamine levels which in turn can give you phenylaturia or homocysteinuria. Phenylaturia causes high ammonia levels which alkalize the digestive system and bladder making us prone to infection and dysbiosis. Protease enzymes may help with that. Meat is high in phenylalanine if you get ill after eating meat then you may have a problem.

If you eat foods that raise your glutathione levels like cruciferous vegetables then you may have a CBS pathway blocked which can make you feel ill. What helped me with that was P5P, Methylcolobamine and Molybdenum which I only take a few times a week.

— Avoid things high in tannic acid, such as coffee.

— Do not drink alcohol.

— Many things in processed foods can cause leaky gut, so try to eat foods made from whole, fresh ingredients.

Processed Sugar causes inflammation so try your best to avoid it in all its forms. Other sugars like those found in fruits, honey, organic black strap molasses have been found to fight pathogens and actually promote healing.

Lowering Histamine levels. Leaky gut causes high histamine levels which causes a loop that prevents us from healing because histamines cause inflammation.

Avoid foods high in histamines especially fermented foods, cheese and yogurt. Also avoid aged meats. Everyone is different, some can eat one high histamine food and not another and vice versa.

Things that help lower histamine levels. There are many protease enzyme that help with that I used Bromelain and Betaine along with serrapeptase because it helps dissolve scar tissue caused by chronic disease and also lowers histamine levels. Be careful even those protease enzymes are good for lowering histamine and homocysteine levels if taken to often it can lower your homocysteine levels too low.

Other protease enzyme that are supposed to work well like Papain and Nattokinase I have never tried them. Nattokinase is supposed to help with renal and lymph blockages. Nattokinase is supposed to help reduce carcinogenic estrogen levels.

American Skullcap Tea – not to be confused with chinese which has different health benefits. American Skullcap promotes relaxation, reduces seizures, inhibits food allergies. Has amazing healing abilities. I did experience problems with this at first because it improve the health of blood vessels and helps repair nerves. When I started to heal my nerves and muscles woke up and all heck broke loose. I had bad charlie horuses and burning in my nerves for three days but once my body got used to them working again it was like a big weight was lifted off and I could feel myself healing.

Wasabi – reduces risk of cancer and heart disease, has anti-inflammatory properties. Helps fight bacterial infections. It also reduces allergy symptoms and detoxes the body. Wasabi is packed full of nutrients.

Detoxing

Luffa Gourd – Strengthens the immune system, reduces fevers, detoxifies the body and aids the body with hydration. Has been shown to reduce heart palpitations and hair loss.

Oregano Oil – contains Carvacrol which protects the liver, has been shown to inhibit cancer growth. Works as a good nontoxic disinfectant. Has been shown to be as affective as chlorine. It kills Candida and helps protect the cardiovascular system from LDL and reduces inflammation.

Kills many pathogens.

Carnosine – detoxes the bodies cells of heavy metals has been shown to reduce some aging. Good sources are avocados, beans, bran, brewers yeast, brown rice, nuts, seeds, watercress, and spirulina.

L-ornithine and arginine is needed in the urea cycle to remove ammonia and other toxins from the body. Good sources of these are legumes,vegetables,nuts, seafood and seeds.

Indian Paintbrush (Castilleja) Only the flowers are eaten, the rest of the plant is too high in selenium. Has similar health benefits as garlic. It enhances the immune system. Helps the body to detox, the rest of the plant is too high in selenium to consume.

Garlic , Dandelion Tea, Red Rooibos Tea, Chlorophyll and Rattan tea are all good at detoxing the body. The protease enzymes also help with detoxing.

Lemmongrass – Lowers LDL, helps get toxins out of the body and lowers uric acid levels. Has been shown to be affective against cancer.

The essential oil has antimicrobial properties and has been shown to be affective against H-Pylori. Has also been shown to aid colitis. Calms muscles and nerves Helps relive pain including headaches. Has been shown to reduce the occurrence of convulsions and helps repair the immune system.!!Be careful some have had an allergic reaction to this.!!

White Peony Root – reduces diabetes induced oxidative stress. Decreases urinary albumin. Protects the liver from oxidative stress. RDA is 100 to 200 mg per kilogram of weight.

These are things that helped me heal.

Research them to see if they would help you.

Silymarin- milk thistle, heals cell damage helps repair methylation pathways. Helps repair nerve damage. I have heard complaints of this making people ill this is because certain liver disease can cause high iron levels and milk thistle is high in iron.

Kelp – has iodine which is needed by the body to keep the thyroids unblocked and to detox the body. Also has mucilage which helps heal the gut.

Aegle Marmelos – leaves are used. Inhibits lipid peroxidation, protects cells from damage, has antibacterial properties. Has been shown to fight cancer and is an adaptogen. Used to reduce chronic fatigue symptoms.

Vitamin D3 protects the cardiovascular system and nerves. Helps keep the immune system healthy. Us natural man made has been shown to have side effects. You should not take more then 4,000 IU, high doses can cause oxalates.

Ubuquinol- unoxidized form of CoQ10, use to provide the chromosomes with energy.

Quercetin- Helps heal leaky gut and nerve damage. The highest sources are elderberry juice, capers, Lovage, radish leaves, dill, Juniper berries, onions, red leaf lettuce, watercress and hawthorne leaves.

Honeysuckle- helps with cardiovascular issues and heals smooth muscle. Helps detox the body. Has mucilage which helps heal the gut.

Myricetin- helps reduce the symptoms of diabetes. Also shown to protect the nerves. Good sources are parsley, currants, yellow dock, cranberries, seeds, and blueberries. Has been shown to fight viral infections.

Kudzu- reduces histamines, and eases gastrointestinal problems. Lowers sugar levels. Helps fight cancer and is affective at aiding in suppressing alcohol cravings. Has been used to treat angina. Is an adaptogen so will help with adrenal fatigue.

Bacopa – heals brain and nerves, improves memory. Reduces ammonia levels in the body. Helps heal blood vessels throughout the body. Amazing herb.

Barberry – reduces swelling in spleen, antibacterial and anti-inflammatory. Has been shown affective against protozoa infections.

Tart Cherry capsules – helps fight heart disease , cancer, neuro-degenerative disease. Protects against muscle damage.

Maca Root helps replenish nutrients especially electrolytes. Is an adoptogen helps to balance the bodies hormones.

Ellagic Acid – inhibits binding of carcinogens to DNA. Reduces oxidative stress.

Sources are Black Berries, Cranberries, Raspberries, Strawberries, Walnuts, Grapes and Peaches. Must be coated to survive the stomache acid.

Tyrosine – if you are not methylating properly your body cannot produce it. It is used by your body to build neuro transmitters and various proteins.

Good sources are nuts, avocados, bananas, dairy products, beans and seeds.

Lotus Root – Improves digestion, reduces LDL, reduces stress hormones, strengthens the immune system and is loaded with many nutrients. Helps heal the gut.

Moringa Oleifera reduces oxidative stress and the illnesses cause by it. Helps heal leaky gut and reduce the risk of kidney stones. Also fights many infections.

Black Currant Seed Oil (Ribes Nigrum) Good source of Gamma-Linolenic Acid. Reduces arthritis symptoms, gastritis, stimulates production of anti-inflammatory hormones, helps suppress Postglandulin E2 boosting the immune system. Has been shown to be very affective at protecting the body from the flu.

Gotu Kola – has many minerals needed by the body. Has been used to treat syphilis, hepatitiis and other infections. Improves blood flow and reduces swelling in the legs.

Wild Bergamot (Monarda Didyma) – also known as horse mint. reduces fevers and nausea. Helps prevent cell damage. Has very strong antimicrobial properties. Has been shown to reduce gastric pain.

Biacalein (Thihydroxyflavone) – From the roots of Scutelleria Baicalense , Scutelleria Lateriflorg, and Oroxylum Indicum, also found in plantain herb and fleabane. Anti-inflammatory, helps heal smooth muscle also has antidepressant properties.

Glycoproteins – molecules that contain a sugar and a protein. They permit healthy cell to cell communication. They have been shown to fight bacteria, viruses, and cancer. They prevent carcinogens from attacking cells and making changes. They have been shown to strengthen the immune system.

Some have allergic reactions to them. I suspect it may be a herx reaction to a pathogen they may have that is dying off.

Foods high in Glycoproteins are mushrooms like the Reishi, Maitake, Cordyceps, Shitake and Oyster Mushrooms. Many dark colored fruits and vegetables contain them. Another source is whey protein. If you buy whey protein be careful if you have methylation problems because many companies add phenylalanine.

Choline – Needed to break down fats so our bodies can use them. Choline also helps with nerve repair. It also helps provide the body with more energy. Sources of Choline are eggs and milk products. The white parts of melons and the seeds of melons. If you get ill or indigestion when eating high choline foods it could indicate you are dealing with porphyria. I have posted on it.

Sulfur – has antimicrobial properties, has been shown to kill Candida. Sulfur is used in most processes in the body. Helps protect the lymphatic system and keep it healthy which important in the proper function of the immune system. If we do not get enough sulfur our Lymphatic System can become blocked.

Good sources of Sulfur are cruciferous vegetables, onions, garlic, kale, egg yolks from free range chickens. Cooking helps release sulfur from foods. Those with methylations issues and high sulfite levels need to address that before eating high sulfur foods.

Butchers Broom lowers ammonia levels, helps with hemorrhoids, reduces oxidative stress, has been shown to reduce the symptoms of POTS and Cardidtis. Has strong anti-inflammatory properties. Those with type 1 diabetes should not use this they could develop ketoacidosis.

Savory – has Oleanolic Acid and antioxidants. Aids in the repair of DNA. Is also an antispasmodic. Helps unblock Nrf2 pathway.

Mullein (verbascum thapsus) Has antibacterial and expectorant properties. Has also been shown to fight mycobacteria, Is a natural anti-inflamatory. Helps ease menstrual and stomach cramps. Helps normalize estrogen.

Zinc is necessary for the synthesis of proteins. Zinc is important for the proper function of the immune system, keeping eyes healthy, for healthy skin, protecting memory, repair and function of DNA and strengthening of bones.

Good sources of zinc are ginger root, fish, oats, whole wheat, !!Too much zinc inhibits the bodies ability to absorb copper!!

Chirata – reduces fever, fights things like malaria, Candida and parasites, also reduces nausea. Used in tincture form.

Cinnamon relieves gas, nausea, kills bacteria,H pylori, and Candida has been listed as a very affective pain killer.

Bee Pollen has many of the nutrients the body needs, it is a super food. High in protein.

Grape Seed Extract – thins the blood, reduces bradykinin which causes inflammation and damages nerves and smooth muscle. Also has many healing properties be careful it thins the blood. Helps with carditis. High in reveratrol.

Narigenin – found in grape fruit. Reduces histamines and inflammation. Has been shown to repair DNA. Reduces Hepatitis C. Has antidepressant affects. Cannot be taken with most medications. This inhibits cytochrome P450 enzymes needed to detox medication from the body. It should not be taken often but has been found to be very effective against gut dysbiosis. I only took it twice a week and it really reduced my bloating.

Fisetin- reduces inflammatory cytokines. Can up-regulate gluthione production. Good sources are most berries, fruits and vegetables. It also has nueroprotective properties.

Catuaba Bark – Opens blood vessels so blood can flow more easily, has anti-inflammatory properties, protects the skin from damage, has been shown to reduce symptoms of Parkinsons disease, has antidepressant affects, has been shown to be affective against HIV and other viruses.

Baai (Puerariathunergiana) – antiviral,antispasmotic, lowers blood pressure, shown to help with alcoholism. Scavenges free readicals and reduces alleric reactions. Makes HIV drugs more affective.

Caesalpinia Sappan – antibacterial, anti-inflammatory, reduces aging, protects liver and reduces acne. Helps prevent Peroxide formation, and lowers blood pressure.

Fulvic Acid – Helps the bodies cells to release heavy metals. Helps protect the brain from cognitive impairment. Promotes electro chemical balance throughout the body. Makes minerals more biochemically available. Has been shown to revitalize dying cells. !!Research has not been done on large dose intake of Fulvic Acid so do not overuse or take in large quantities.!!

Lower Cortisone

Lowering stress hormones can reduce histamines.

Eucommia Bark – encourages collagen development, lowers blood pressure. It does not lower blood pressure in those with low blood pressure. Strengthens the immune system and lowers stress hormones.

Purines and Pyrimidines – essential for building molecules that carry our genetic code and produce the proteins necessary for a healthy body.

Foods that support their production are foods high in glutamine, glycine and aspartate like greens , cabbage, oats, eggs, lentils, peanuts, almonds, legumes, all increases our production. !!If you have gout or inflammation high purine foods can make it worse, you may want to decrease your intake of animal flesh, asparagus, beans, legumes, mushrooms, scallops, sardines,coffee, tea and cocoa.

Lionsmane – high in protein, has neuro-protective properties. Lionsmane has been shown to improve memory and reduce plaque in the brain, it has also been shown to reduce depression.

Uridine – -Helps DNA repair. Foods that increase uridine are beer, wine, tomatoes, brewers yeast, broccoli, fish, nuts, molasses and Non GMO beets.

Suma Root – (Pfaffia Paniculata) an adaptogen, reduces fatigue, normalizes estrogen and testosterone. High in electrolytes and other nutrients.

Useful Info On Food And Herbs.

These are a list of things I have found in my research to try to heal from Lyme. This is not medical advice if you are not well see a doctor. If you take any supplements or herbs let your doctor know. Only take one new item at a time so if you have a reaction you will be able to figure out what caused the reaction. A good site for drug interactions is http://www.webmd.com .

Try your best to stay away from GMOs and vaccinations,processed foods with their saturated fats. By now you should know the harm they do to your body. I put this list together to give others an idea on some things they could research.

CoQ10 – Ubiquinol which is the unoxidized form of CoQ10 is the most bio-available form. It protects the mitochondria, cardiovascular system. It helps with the bodies energy production at the cellular level. It helps regulate blood sugar levels and improves the health of the immune system. It is fat soluble so must be taken with a healthy fat. Recommended Daily (RDA) allowance is 90 to 100 micrograms (mcg)

Lipoic Acid – First line of defence for disease. Regenerates antioxidants. Bio-active form is R-Alpha-Lipoic-Acid.

L-Carnitine – required to transport fatty acids to mitochondria, protects and heals nerves. Protects and heals nerves. Found in meat and milk products, also found in asparagus. Also helps remove toxic compounds generated in cells.

L-Glutamine – heals soft tissue.

Some sources are chicory root, Jerusalem artichoke, dandelion root, burdock, salsify, onions, and garlic.

Probiotic With Active Acidophilus and Bifidus – helps restore good gut bacteria. The good gut bacteria helps protect from cancer and infection, it also helps break our food down. Do not over do them or they will do the opposite.

Fermented Foods – Helps restore the bodies good bacteria, protects from infections and helps break our food down.They are high in histamines so if you are having high cytokine levels avoid fermented foods. Those with allergies or mast cell activation syndrome should avoid fermented foods.

Vitamin E (Tocopherols, Tocotrienols) With vitamin E always make sure it does not start with the letters DL, if it does then it is man made and our bodies does not use it very well.

Vitamin E Helps with energy production in the cells, protects the cardiovascular system, it is also and antioxidant. Sources of Vitamin E are nuts, seeds, greens, dark colored fruits and vegetables most organic cooking oils.

Vitamin C most bio-available form is Liposomal Vitamin C. The body needs Vitamin C to detox and repair the body. It has also been shown to fight many pathogens. Helps the body absorb Iron more readily. !! If you take too much Vitamin C you can flush important minerals from the body. It can also destroy red blood cells , also too much vitamin C can raise oxalate levels.!!

Virginia Pepperweed – contains isothioyanates which have antibacterial, antifungal, anticarcinogenic and anti-parasitic properties.

Allspice – anethetic, antioxidant, relaxant, stimulates blood circulation, stimulates cell growth and repair. !! In high doses causes many side affects. !!

Cat’s Claw – helps the body detox, also works as an adaptogen on the immune system.

Avena (Oat Straw) Helps balance our electrolytes. Has many nutrients needed for healing and proper functioning of the lymphatic system, helps improve cardiovascular health. Also has relaxant qualities and kills pain. Most say it doesn’t affect them but it knocks me out. Kills pain.

Boron helps remove toxins like chlorine.

Molybdenum – reduces oxidative stress, helps remove toxins produced by the body. It is needed to metabolize fats and carbohydrates. Also helps remove many other toxins from the body. Most do not need to supplement this. Good sources are greens, vegetables, seeds, melons, unfiltered water. Make sure you do not get too much. I sign of not having enough molybdenum is high ammonia levels.

Oleanolic Acid – Found in Olive Oil and Savory. It has been shown to unblock the Nrf2 pathways. If the Nrf2 pathways are blocked DNA and RNA cannot repair.

Vitamin D3 – helps regulate gene expressions, it also helps regulate epigenetic DNA methylation processes. Vitamin D3 has been shown to protect the cardiovascular system, it also aids in the absorption of calcium.

Zinc – Helps with DNA repair and synthesis of Protein. It is important for the proper function of the immune system. It helps keep the eyes, skin and memory healthy. It helps strengthen our bones. !! Too much Zinc can inhibit the bodies ability to absorb copper.!!

Good sources are shellfish, Oats, Whole Wheat, Ginger Root

Iodine – helps detox the body. It controls the function of the thyroid glands which affect metabolic processes in the whole body. It helps optimize the use of our bodies calories. The RDA is 75 to 150 mcg. Good sources of Iodine are seafood and seaweed. Unfortunately most sources of those are contaminated. Most table salt is enriched with iodine. Too much iodine can cause problems with the thyroids.

Magnesium – important in all the bodies functions, supports the immune system, prevents inflammation, reduces the risk of heart attacks.

Intake of Magnesium and Calcium should be balanced as closely as possible. The recommended RDA is 400 mg. Sources of Magnesium are leafy greens, bananas, most fruits and vegetables, oatmeal and chocolate. Most foods contain adequate amounts of calcium.

Calcium – Important for healthy bones and cardiovascular system. It is important for the regulation of the sodium pumps that control our muscles. Good sources of Calcium are found in greens, veggies, oranges and shellfish. Most foods contain adequate amounts of calcium and it is rare to need to supplement calcium. Most bone loss is from silica or magnesium deficiency.

Cholesterol – the body can produce Cholesterol. It is necessary for all body functions especially the brain. It helps the body break down and absorb fats. It is also important in the manufacture of hormones and balancing of the hormones. It is an antioxidant that protects our bodies from cancer. It is critical in the repair of damaged cells. A deficiency in Cholesterol can cause Leaky Gut Syndrome.

Sources of good Cholesterol are meat from grass fed animals, eggs, avocados, legumes and beans.

LDL is the oxidized form of Cholesterol which is bad for our bodies. It is found in grain feed meat, and processed foods.

Protease Ezymes – Supports good gut bacteria. Have been shown to aid with digesting cell walls of pathogens. Helps with methylation and lower homocystein levels which will lower ammonia levels. Some protease Enzymes are bromelain from pineapple, betaine from beets, and Papaya. Be careful of your source because there are GMO Papaya and Beets now. Nattokinase is a protease enzyme that has been shown to help with fatty liver disease. Serrapeptase reduces inflammation, reduces scar tissue in the body and improves blood flow.

Hops Tea inhibits cancer, known to remove many toxins from the body. Protects the renal system. Promotes proper functioning of the thyroid and has been shown to protect the cardiovascular system. Has been shown to fight many infections, even reduces aids symptoms. Has a cannabinoid that reduces pain. !! Overuse can cause seizures!!

Vitamin K2 – Prevents Osteoporosis, protects us from cardiovascular disease. Reduces cancer and Alzheimer conditions. It controls were calcium goes and does not go. Helps with the function of the muscles.

Good sources of Vitamin K2 are milk from grass fed cows for some reason grain fed cows do not produce very much K2 !! Do not confuse with K3 which is man made and toxic to the body.!!

Biotin – regulates gene expressions. Reduces CO2 levels in the body.

Some food sources are egg yolk, whole grains and cheese.

Lycopene – Helps protect the heart and reverse damage to the heart. Sources of Lycopene are cooked Tomatoes, grapefruit, pretty much all colored fruits and vegetables. Cooked tomatoes are the best source though.

Hyaluronic Acid – helps heal connective tissue throughout the body and skin.

Tumeric – contains Curcumin which has been shown to reduce MS sysmptoms and fight cancer. Has antimicrobial properties. It has also been shown to protect the renal system. Fresh ground pepper makes it more bio-available to the body. Should not be taken too often or for too long. Curcumin chelates iron so if taken for too long you can become anemic. It good for those suffering from iron overload.

Ginger – has many micronutrients and antioxidants. Has been shown to reduce inflammation. Improves blood flow. It improves the absorption of nutrients into the body. It stimulates the pancreas and is a natural pain killer. Has been shown to induce cell death in cancer cells. Promotes bone health and reduce menstrual cramps. Helps fight nausea and fight infections. Has been shown to heal the gut. I reacted to this the first few times I used it but after that I was fine.

Horsetail Herb – contains silica which the bones need for healing and to remain healthy, silicon is also needed by the body for detxoing. !!Some studies claim to much silica can cause kidney stones and others claim it does not. I would not over use. Do not take often, horsetail does contain a chemical that can be toxic if taken in excess!! Horsetail herb also has an alkaloid that can build up in the body so I would not use this often.

Panax Ginseng – Impedes cancer growth and promotes cancer cell destruction. Improves circulation which improves healing.

Rehman – helps with detoxing, has been shown to reduce fibromyalgia symptoms. Also helps regulate the immune system. !! Can cause bloating!!

Honeysuckle – many antioxidants, has been shown to kill bacterial infections. Heals smooth muscle and cardiovascular system. This one helped with my myocarditis.

Policasamol – prevents blood clots helps regulate blood pressure, also balances cholesterol. It is extracted from sugar cane. It reduces inflammation.

Butchers Broom – Has been shown to reverse osteoporosis. Lowers ammonia levels in the body.

Evening Primrose (Oenothera Biennis) Has Gamma Linolenic Acid (GLA) which has been shown to heal many areas of the body even smooth muscle. Very good for skin health.

Citruline – helps remove ammonia from the liver. Helps strengthen the immune system. Also helps to maintain nitrogen balance in the body. Studies have shown it reduces atherosclerosis. Helps reduce fatigue and increase energy in the body.

Sources of Citruline are melons, sguash, legumes, and protein rich foods.

Clary Sage – benefits eyes, nervous system, also aids in digestion. Helps regulate blood pressure and normalize it. Has antispasmodic properties.

Eupatorium Perfoliatum – also known as Boneset and Feverwort. It has been shown to be affective against the common cold and the flu. Aslo affective at treating cytokine dysregulation. Has been shown to be very affective against the plasmodian parasite.

White Peony Root – reduces diabetes induced oxidative stress. Decreases urinary albumin. Protects the liver from oxidative stress. RDA is 100 to 200 mg per kilogram of weight.

Bupleurum – promotes new vein growth and strengthens capillaries. !!Stimulates the immune system and causes flatulence!!

Coltsfoot – anti-inflamatory and eases coughs.

Fireweed – Helps normalize gut flora, supports the good gut bacteria. Reduces inflammation and symptoms of irritable bowel syndrome.

Silver Weed (Potentilla Anserina) The leaves have antiviral properties, and contains more flavonoids then green tea. Has been shown to be hepatoprotective.

Manganese – Necessary for proper brain function and pituitary function. Manganese is also necessary for healthy bones and works as a coenzyme to assist in metabolic activity.

Good sources of manganese are berries, pineapple, garlic, greens, Non GMO beets, fruits, vegetables, molasses, and coconuts.

L-Dopa (Levodopa) The body uses it to make Dopamine. Our bodies will produce it but many who are ill do not produce enough.

Good sources of L-Dopa are Fava Beans, Mucuna Pruriens, and Broad Beans. Those who are G6PD deficient should not eat Fava Beans.

Good carbohydrates – Good carbohydrates stabilize things throughout our bodies. Good sources are sweet potatoes, oats, brown rice, legumes, beans, quinoa, fruits and vegetables.

Jaiogulan – (Gynostemma pentaphyllum) Helps the body achieve homeostasis by lowering oxidative stress. Has many of the same phytochemicals as gensing. Reduces oxidative stress and inflammation.

Uridine – -Helps DNA repair. Foods that increase uridine are beer, wine, tomatoes, brewers yeast, broccoli, fish, nuts, molasses and Non GMO beets. I would not supplement , high levels of uridine can stimulate cancer growth. That being said uridine stimulates growth of brain and nerve cells. It reduces pain and inflammation. It increases cognitive abilities. It works best if consumed with fish oil.

Wasabi – reduces risk of cancer and heart disease, has anti-inflammatory properties. Helps fight bacterial infections. It also reduces allergy symptoms and detoxes the body. Wasabi is packed full of nutrients.

Oregano Oil – contains Carvacrol which protects the liver, has been shown to inhibit cancer growth. Works as a good nontoxic disinfectant. Has been shown to be as affective as chlorine. It kills Candida and helps protect the cardiovascular system from LDL and reduces inflammation.

Lionsmane – high in protein, has neuro-protective properties. Lionsmane has been shown to improve memory and reduce plaque in the brain, it has also been shown to reduce depression.

Luffa Gourd – Strengthens the immune system, reduces fevers, detoxifies the body and aids the body with hydration. Has been shown to reduce heart palpitations and hair loss.

Nobiletin – prevents metabolic syndrome. Protects from obesity, prevents artheriosclerosis. This is extracted from the peels of citrus fruits. Stimulates cellular macrophagy. Should not be used more then a couple times a week.

Fulvic Acid – Helps the bodies cells to release heavy metals. Helps protect the brain from cognitive imparement. Promotes electro chemical balance throughout the body. Makes minerals more biochemically available. Has been shown to revitalize dying cells. !!Research has not been done on large dose intake of Fulvic Acid so do not overuse or take in large quantities.!!

Aerva Lanata – has diuretic, anti-inflammatory, antispasmodic, antiparasitic, antimicrobial, hepa-protective and anti-asthmotic properties.

Agrimony – reduces inflammation, improves digestion, improves bladder control, detoxes the body and improves hair and nail health.!!Taking too much can cause constipation!!

Cissus Quadrangularis – reduces inflammation, improves bone health, improves respiratory health, eases pain and stimulates the production of osteoblast which are needed for bone growth and healing.

Camu Camu – high in vitaminb C, helps block build up of plaque in the brain, reduces symptoms of depression, improves muscle tone.

Black Radish – used to treat nutritional deficiencies. Helps remove toxins from the blood. Has antimicrobial and antibacterial properties.

Eucommia Bark – encourages collagen development, lowers blood pressure. It does not lower blood pressure in those with low blood pressure. Strengthens the immune system and lowers stress hormones.

Moringa Oleifera – has antibacterial properties. Has been shown to stabilize blood pressure. Helps reverse some liver damage. Contains Quercetin. The seeds have been shown to improve asthma symptoms. Also reduces histamine levels.

Graviola (Annona Muricata) – soursop has been shown to kill cancer cells, suppresses the herpes simplex virus. Has been shown to reduce swelling and pain. !!Taking to long or too much can damage nerves. !!

Celery Seed Extract – reduces risk of stroke. Improves blood flow and has been shown to protect the brain. Also lowers histamines and inflammation. Has been shown to help heal leaky gut.

Periwinkle – helps bleeding gums, reduces Alzheimer symptoms, reduces headaches and vertigo.

Black Currant Seed Oil (Ribes Nigrum) Good source of Gamma-Linolenic Acid. Reduces arthritis symptoms, gastritis, stimulates production of anti-inflammatory hormones, helps suppress Postglandulin E2 boosting the immune system. Has been shown to be very affective at protecting the body from the flu.

Olive Leaf Extract – has antibacterial , and anti-inflammatory properties. Lowers blood pressure and LDL levels. Olive Leaf Extract has been shown to protect the cardiovascular system. It is a broad spectrum antiviral and antimicrobial agent. !!Be careful it can drop your blood sugar levels.!!

Aegle Marmelos – leaves are used. Inhibits lipid peroxidation, protects cells from damage, has antibacterial properties. Has been shown to fight cancer and is an adaptogen. Used to reduce chronic fatigue symptoms.

Hydrangea Macophylla Root – helps with autoimmune disorders while allowing the immune system to function normally.

Bethroot (Trillium Erectum) Stimulates menstration, is an expectorant, can stimulate labor during pregnancy.

Acanthus Ilicifolius – increases production of osteoblast which are necessary for bone growth and health. Has been shown to help gastric ulcers heal. Has strong antibacterial and antifungal properties.

Boabab – high in vitamin C, much more then oranges. Has very good hepaprotective properties. Loaded with minerals. Can be purchased as a powder.

Bakula (Mimusops Elengi) diuretic, gastroprotective, antibacterial, antifungal, anticancinogenic, scavenges free radicals, has been shown to hinder HIV.

Cynanchum Stauntonii – improves endothelial function, inhibits the formation of atherosclerosis.

Ajuga Decumbens improves liver and kidney function, helps correct hypoglycemia.

Caesalpinia Sappan – antibacterial, anti-inflammatory, reduces aging, protects liver and reduces acne. Helps prevent Peroxide formation, and lowers blood pressure.

Sea Bean (Salicornia) – High in protein,calcium and iodine. Has many micronutrients.

Bitter Ash (Picrasma Excelsa) Reduces colitis symptoms, and has antiviral and antibacterial properties.

Cancer Bush (Sutherlandia Frutescens) Fights cancer has been shown to reduce HIV symptoms.

Maytemus Heterophylla – has antibacterial and antimicrobial properties. Reduces inflammation.

Baai (Puerariathunergiana) – antiviral,antispasmotic, lowers blood pressure, shown to help with alcoholism. Scavenges free radicals and reduces allergic reactions. Makes HIV drugs more affective.

Catuaba Bark – Opens blood vessels so blood can flow more easily, has anti-inflammatory properties, protects the skin from damage, has been shown to reduce symptoms of Parkinsons disease, has antidepressant affects, has been shown to be affective against HIV and other viruses.

Spatholobus Suberectus – strong antiviral, improves the health of blood, reduces arthritis symptoms, anti-inflammatory, affective against cancer, thins blood and has sedative affects.

Quaking Aspen (Populus Tremuliodes) High in salicylates which is converted to aspirin in the body. Reduces pain, fever, inflammation, thins blood, detoxes the body and has antibacterial properties.

Club Moss, Devils Claw (Lycopodium Clavatum) anti-inflammatory improves memory.

Bee Pollen – High in protein, contains almost all nutrients required by humans. There is a substance in be pollen that inhibits the development of bacteria. It strengthens our blood. Normalizes cholesterol and has been shown to help fight cancer.

Geranium Pelargonium – this is the only Geranium species that can be consumed. It is an adaptogen, reduces stress hormones, reduces pain and inflammation, reduces headaches, helps the body to detox by stimulating the kidneys. Has antifungal and antibacterial properties. Has been affective at reducing cold and flu symptoms.

Wild Bergamot, Horse Mint ( Monarda Didyma) Settle stomach, reduces fevers, helps prevents cell damage, helps with urinary tract infections.

Indian Paintbrush (Castilleja) Only the flowers are eaten, the rest of the plant is too high in selenium. Has similar health benefits as garlic. It enhances the immune system. Helps the body to detox, the rest of the plant is too high in selenium to consume.

Apple Leaf helps heal the gut.

https://link.springer.com/article/10.1007%2Fs13765-015-0021-2

Lemon Verbana (Glycyrrhiza Glabra) reduces muscle damage, improves joint mobility and reduces joint pain. Improves the health of the immune system.

Red Rooibos Tea (Aspalathus Lenearis) Has antiviral, anti-inflammatory,antimutagenic qualities. Scavenges free radicals. It is a relaxant with many minerals needed for bone health. Protect the cardiovascular and pulmonary system. Helps with colic in babies. Also helps detox the body and is very good for fighting lung infections.

Star Grass (Hyposis Hemerocallidea) Has antibacterial and anti-inflammatory properties. Has been shown to be affective against breast cancer. Has been shown affective against HIV.

Lithospermum Erthrohizon – inhibits HIV virus, prevents ovalation in women with no side affects. Also hinders hardening of the arteries.

Sweetflag (Acorus Calamus) reduce epilepsy symptoms. Kills Candida and fungal infections. Hinders inflammatory cytokines. Has been shown to be affective against cancer.

Bixa Orellena (Annatto) – Used to treat gonorrhea and many other bacterial infections. Helps prevent DNA damage. Reduces oxidative stress and protects the renal system.

Bearberry (Uva Ursi) helps with urinary tract infections. I have seen websites saying it can damage the liver but when I looked at toxicity studies it showed it to be safe. It reduces oxidative stress and kills infections in the renal system.

Pau D Areo Tea (Tabebuia Allanedae) – Fights cancer, kills bacterial infections, and is affective at killing parasites. !! Do not concentrate it contains Quinone which can damage the liver in high doses.

Use no more then two 8 ounce cups a day.!!

Mustard – anti-inflammatory. Has been shown to help with chest congestion. Very high in antioxidants and lowers LDL.

Sage reduces muscular pain, improves memory and reduces oxidative stress.

Sarsparilla (Smilax) Has been used to treat gonorrhea, leprosy, bacterial and viral infections. Has anti-inflammatory affects. Has been shown to limit the amount of toxins that can enter the blood stream. It protects the renal system and reduces oxidative stress.

Vitex (Chasteberry) Supports the endocrine system. Works as and adaptogen for women.

Thyme (Thymus Vulgaris) Shown to increase white blood cell production. Has a relaxing affect on the muscles. Has been shown to reduce oral infections. Has many minerals like copper, iron, and manganese. It boost the feeling of well being. !! If taken in large doses has many side affects!! Also will work as an insect repellent.

Andrographis – fights many pathogens. It has many antimicrobial properties. Boost the bodies immune system. Can prevent and dissolve blood clots. Relaxes smooth muscle which lowers blood pressure.

!!Has many side affects!!

Galangal Root (Alpinia Officicaram) Relieves nausea, has antifungal and anti tumor properties.

Golden Rod (Solidago) a diuretic, has been shown to fight bacterial and urinary tract infections. Eases muscle spasms and reduces high blood pressure. Helps with reducing ammonia and other toxins in the body.

Juniper Berries – has been shown to inhibit bacteria growth. !!Long term use can cause liver damage!!

Schisandra – has antioxidants and anti-inflammatory properties. It is also an adaptogen. It has been shown to reduce stress hormones and improve concentration. Has been used to treat hepatitus. !!only use a few berries at a time and not for extended periods of time.!!

Tribulus Extract (Puncture Vine) Boost endurance and helps increase muscle mass. Similar chemically to anabolic steriods. Boost testosterone production. Strengthens the immune system. Reduces oxalates in the body.

Mullein (Verbascum Thapsus) has antibacterial and expectorant properties. Has also been shown to fight mycobacteria. Is a natural anti-inflammatory. Helps ease menstrual and stomach cramps.

Siberian Ginseng – each type of ginseng has it’s own properties. You must research which ones are best for you. Siberian Ginseng is an adaptogen. It has been shown to lower stress hormones. Studies suggest that it may strengthen the immune system. It has been shown to reduce the number of outbreaks of herpes. It has also been shown to improve mental health. !!Do not give to a child, if you have high blood pressure do not take.!!

Ladies Thumb (Polygonum Persicarla) Has antiherpetic properties. High in saponins which aren’t toxic but if consumed in high quantitites they can inhibit nutrient absorption.

Smartweed (Polygonum Pennsylvnicum) Has the same properties as Ladies Thumb, looks similar also.

Myricetin is a heliacase inhibitor. Helps fight viral infections. Also has anti-inflammatory properties. Has many antioxidants. Most dark colored produce contains Myricetin.

Croton Lechleri the sap is latex and is used as a liquid bandage. It has been shown to heal gastric ulcers.

Borage – Contains choline which is needed for methylation. Shown to reduce stress hormones. Do not use in hight doses or it will do the opposite. It contains an alkaloid that can damage the liver and kidneys if it builds up in the body.

Noni Extract has antioxidants and immune boosting properties. Helps lower blood sugar and is high in pottassium.

Hovenia Dulcis – protects the renal system, reduces oxidative stress. Helps to protect the brain. RDA 1400 to 2500 mg.

Polygala Tenifolia – reduces stress hormones improves memory.

Bacopa – heals brain and nerves, improves memory.

Bromelain extracted from pineapple. Reduces pain and inflammation. Has anti parasitic and antimicrobial properties. Kills Candida. Promotes muscle and connective tissue repair.

Aloe Vera contains Latex which helps heal leaky gut. Has been shown to kill Candida and help regulate the immune system. I get the liquid capsules, I do not like the textures of the juice. The dried capsules didn’t seem to work. Has been shown to reduce histamine levels.

Chamomile – reduce muscle spasms, reduces pain and menstrual cramps. Also reduces histamines.

Wild Daisies -related to Chamomille does the same things only taste better.

– reduce muscle spasms, reduces pain and menstrual cramps. Also reduces histamines. Also reduces pain and has mild sedative effects.

Tongkat (Eurycoma Longifiolia) enhances bodies adaptive response to exercise, also increases testosterone levels.

Muira Puma – aprodisiac in men and women. Helps the body produce healing hormones.

Maca Root gives the body energy. High in minerals and vitamins. Stimulates and nourishes the hypothalamus and pituitary glands which control all other glands. Helps the body achieve homeostasis.

Dandelion – high in vitamin K, has been shown to protect the renal system and to aid in the removal of toxins from the body. Has many antioxidants and micronutrients that help fight cancer. Reduces histamines.

Ellagic Acid – inhibits binding of carcinogens to DNA. Reduces oxidative stress.

Sources are Black Berries, Cranberries, Raspberries, Strawberries, Walnuts, Grapes and Peaches.

Potassium -helps keep the heart healthy, aids in blood flow, helps keep muscles healthy, helps protect nerves also helps the liver filter blood. Helps balance our water levels. !! Too much can cause major heart issues.!!

Sources are Tomatoes, Avocados, Bananas, Oranges, Strawberries, Grapes, Prunes, Beans and Legumes.

Astralagus – protects the chromosomes from degredation. Boost immune system and reduces oxidative stress.

Hawthorne – Improves circulation protects blood vessels. Helps with osteoporosis. Reduces oxidative stress.

Vitamin A -allows for proper gene activation within the lymph glands which helps the body develop proper immunity.

Sources are orange colored fruits and vegetables, Kale and fish.

Red Clover Tea – improves bone health, increases estrogen production.

American Skullcap Tea – not to be confused with chinese which has different health benefits. American Skullcap promotes relaxation, reduces seizures, inhibits food allergies.

Prickley Lettuce – contains opiad like Lacturearium, but is not addictive.

Vitex also know as Chasteberry. Supports the endocrine system. Aslo works as an adaptogen for women.

Tribulais Extract (puncture vine) Boost endurance and helps increase muscle mass. Similar chemically to anabolic steroids. Boost testosterone production and strengthens the immune system.

Mullein (verbascum thapsus) Has antibacterial and expectorant properties. Has also been shown to fight mycobacteria, Is a natural anti-inflamatory. Helps ease menstrual and stomach cramps.

Chinese Knotweed (Fo-Ti) Strengthens bone and prevents hair loss. Supports healthy adrenal function.High in oxalates should not be taken if you are not sulfating right or have issues with vitamin C should not take this.

Zinc is necessary for the synthesis of proteins. Zinc is important for the proper function of the immune system, keeping eyes healthy, for healthy skin, protecting memory, reapair and function of DNA and strengthening of bones.

Good sources of zinc are ginger root, fish, oats, whole wheat, !!Too much zinc inhibits the bodies ability to absorb copper!!

Ginger Root improves blood flow, reduces nausea, improves absorption of nutrients into the body, ginger root also stimulates the pancreas, and is a natural pain killer. Ginger Root has been shown to induce cell death in cancer cells. Ginger Root promotes bone health, has been shown to fight infections and reduce menstrual cramps. Reduces histamines.

Horse Gram (Dilichos Biflorus) Help dissolve kidney stones, also kills many pathogens. The seeds are used to make tincture.

Cambogia (Cortexmoutan Radycus) Helps asthma. shown to upregulate Il-4. Cambogia also thins the blood.

Figwort – Good for the lymph glands and improves blood circulation improves the function of the cardiovascular system.!!Do not use if you are a diabetic.

Coptis (Berberine) The root is used. Coptis aids digestion and the pancreas, kills many pathogens and parasites. Usually comes in tincture or powder form.

Vervian – antispasmotic, helps recover nerve function. Relieves menstrual symptoms. Used in tincture or tea form.

Phellodendrum Amurense – Alleviates arthritis pain, improves bone health, helps preserve nerve function, increases glutathione levels, is also antimicrobial.

Woad – (Isatis Tinctoria) Antibacterial, antiviral and has been shown to inhibit cancer. Root used to make tincture. !!Do not use if you are allergic to aspirin.

Chirata – reduces fever, fights things like malaria, Candida and parasites, also reduces nausea. Used in tincture form.

Forsynthia Suspensa – fights lung infections, tonsillitis, and gonorrhea. Forsynthia also thins the blood.

Verbena – antispasmodic and and reduces fever. Flowers used for tea.

Yarrow (Achillea Millefolium) Has antimicrobial properties, lowers blood pressures. Has been used to clot blood in wounds. The essential oil kills mosquitoes.

Eclipta (Eclipta Prostracta) Reduces oxidative stress, protects the liver, has been shown to reduce pain better then aspirin and stimulates hair growth.

Yellow Dock also known as Curly Dock. Has laxative properties, high in iron, also has antibacterial properties. Has Glycosides that aid with detoxing and mineral absorbtion. !! The leaves are High in oxalates which can cause gout and kidney stones do not eat the leaves without cooking.!!

Red Clover – flowers are used to make tea. Has estrogen like affects. Helps with symptoms of menopause. Can reduce estrogen levels if they are high. Works as an expectorant and antispasmodic.

Varuma – Bark, root and leaves are used. Good at breaking up kidney stones, also hinders their formation. Has anti-inflammatory affects. The root is a laxative. Varuma also helps with flatulence and gas pains. !!May cause blistering if used on the skin!!

Tansy (Tanacetum Vulgare) – Leaves and flowers are used. Gets rid of parasites. Also a good insect repellent.

Passion Flower – Aids with opiate withdrawal, has sedative affects. Has been used to treat ADHD. Has been shown to ease symptoms of drug withdrawal. !!Do not drive or operate machinery when using.!! Long term use can damage the liver.

Bitter Mellon also know as Bitter Gourd – Has many vitamins and minerals. Helps with diabetes. Has antiviral and antibacterial properties. !!Overuse can cause digestive problems and headaches.!!

Nutmeg – Strong antibacterial properties. Has been shown to reduce the occurrence of seizures. Good for diarrhea. !!Over use of this can do the opposite, it can cause seizures and could even cause death.!!

Serrapeptase -derived from a type of silk worm bacteria.It aids the moth in digesting the cocoon so it can exit the cocoon. Serrapeptase has been shown to remove scar tissue from fibrosis, break up blood clots, reduce scar tissue in the lungs, break up cyst and even plaque in the blood vessels. It is PH sensitive so it must be coated. Do not take high doses, it can negative impact the body in high doses.

Papain – aids digestion of proteins. Has been own to reduce symptoms of many herpes viruses !!Do not take if you are allergice to papaya, also be careful I think there is GMO Papaya.!!

Spirulina Provides protein, many vitamins and is a good source of chlorophyll. Very high in Gamma-Linolenic Acid. Has the same minerals as milk. Improves blood vessel elasticity, which improves neuro-protective affects. !!Make sure the source is from uncontaminated waters.!!

Opium Lettuce helps with spastic colon.

http://europepmc.org/articles/PMC3638630

Those who have issues with their digestion that causes the food to sit and ferment instead of digesting properly my not want to use apple cider vinegar. It delays digestion even more.

https://www.ncbi.nlm.nih.gov/pubmed/18093343

Yarrow helps heal the gut.

https://www.sciencedirect.com/science/article/pii/S0378874106001565?via%3Dihub

Also read my post on Beta Glucan because it helps heal the gut.

It’s not your genes it is your gut microbiome.

This is not medical advice and should not be taken as such. I am posting this for educational and informational reasons.

 

This is a list of gut microbiota and the conditions they help with.

Probiotic Guide.

https://consumeradvisorguide.org/probiotics-supplement-review/index4.html

I state this often to people. You should not take the same strains of probiotic everyday. It will lead to SIBO which causes major health problems. You have to alternate the strains you take and take a break from probiotics once in a while to let the microbiome balance out. Sibo can lead to metabolic acidosis and many other health problems.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006167/

http://www.beyondmthfr.com/category/home-slider/

Your gut bacteria not your genes is what makes you predisposed to illness. I am going to cover some candida myths at the end of this.

https://www.nature.com/articles/s41467-017-02651-5

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154387

Before you read this you need to understand many scientist fabricate and falsify research. Much of what we believe is not true if you start questioning things you will start seeing through the smoke screens. Many things that have been proven wrong they teach as if they are fact. Germ theory is one of them it has been proven wrong many times.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0005738

https://www.naturalnews.com/022332_disease_medicine_germs.html

https://joedubs.com/the-fallacious-germ-theory/

People do not take it lightly when their perception of the reality of things has been challenged. They have killed people for exposing the truth behind fake science and for publishing true science. We also have the corruption in this political system involved.

http://www.annclinlabsci.org/content/37/3/295.full

https://sciencebasedmedicine.org/persecution-of-scientists-whose-findings-are-perceived-as-politically-incorrect/

Our gut bacteria tell us what to eat.

https://www.scientificamerican.com/article/how-gut-bacteria-tell-their-hosts-what-to-eat/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987188/

Ok now for the information. One mistake people make if their histamine levels go up when they take a probiotic they panic. When you first take a probiotic it sends out a molecule to tell your body to produce histamines. That makes the mucous membrane more porous. It does this so it can enter and establish itself in the mucous membrane. Once it is in and has set up camp it will continually send out a molecule telling the body not to produce too many histamines so it does not kill the good gut bacteria. So initially histamines will rise for a day or two then after they are established they will drop back down. You may bloat when you first take probiotics. It is best to alternate the types you take or you will develop gut dysbiosis. That is as bad if not worse then having Candida. Your gut bacteria keep your bladder and digestive system acidic. If it becomes alkaline which is usually caused by high ammonia levels in the body. High ammonia levels can be a result of inhibited sulfation or having too many sulfur digesting, methane producing bacteria. High ammonia levels can also be the result of high endotoxin or afloxin levels. I experienced Candida and dysbiosis . I found grapefruit seed extract helped a lot. But you can only take it for a few days and you cannot take it more then two days a week because it inhibits cytochrome P450 enzymes. Yogurt , fermented foods and aged meets should be avoided they have histamine producing bacteria in them and will raise histamine and inflammation levels. Once you get things straightened out you can eat those. I take 3 days a week where I do not take any probiotics to prevent dysbiosis. Some Probiotics that reduce histamines.

Bifidobacterium Infintus

Lactobacillus Rhamnosus

Lactobacillus Salivarius

Lactobacillus Sporogenes

Lactobacillus Saccharomyces

Lactobacillus Bouldardii

Lactobacillus Acidophilus

https://kresserinstitute.com/gut-flora-food-allergies-connection/

https://www.drbenlynch.com/histamine-intolerance-probiotics/

https://medium.com/the-mission/3-tips-for-a-healthy-gut-biome-hint-yogurt-is-not-one-of-them-fd302f43143

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537787/

These bacteria are needed by the body but should be avoided if you have high histamines.

Lactobicilli Casie

Lactobicillus Reuteri

Lactobacillus Plantarum

https://bodyecology.com/articles/do-you-have-histamine-intolerance-4-steps-to-rebuild-tolerance

This is a good article on probiotics and histamines.

https://wholenewmom.com/health-concerns/low-histamine-probiotics

An imbalance of gut microbiome can result in allergies.

http://m.pnas.org/content/111/36/13145.abstract

This is another good article on lowering histamines it mentions s few strains of probiotics.

http://www.low-histamine.com/tag/probiotics

High Substance P levels can make our skin peel and cause gut issues. One of the major causes of high substance P is stress. Probiotics that reduce stress reduces substance P. High substance P causes burning skin , it will get worse at night. The worst burning will be in the scalp and down the spine. Because high substance P can make the skin itch it gets mistaken for high histamine.

http://mentalhealthdaily.com/2016/03/01/10-best-probiotics-for-depression-anxiety-gut-brain-axis-modification

This is a very informative article on probiotics.

http://drjockers.com/is-the-gut-brain-skin-axis-to-blame-for-anxiety-and-acne

Good information on choosing probiotics.

http://onlinelibrary.wiley.com/doi/10.1111/j.1574-695X.2005.00026.x/full

Antibiotics and farm chemicals kill this and it protects and heals our gut.

https://biofoundations.org/increasing-and-maintaining-akkermansia-muciniphila-for-a-healthy-gut-microbiome/

https://www.nature.com/articles/nmicrobiol201521

H Pylori prevents allergies and asthma.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888205/

You can balance your gut bacteria but it takes time and persistence.

http://drhyman.com/blog/2016/02/18/how-to-fix-your-gut-bacteria-and-lose-weight/

https://www.biose.com/en/intestinal-microbiota/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156804/

https://www.healyounaturally.com/9-things-you-never-knew-probiotics-could-do-to-improve-your-health/

If you bloat from taking a probiotic it could be you are taking too many or too often, or it could be die off of a pathogen.

https://www.probioticscenter.org/bloating-and-probiotics/

Information on selecting probiotic strains.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1574-695X.2005.00026.x

http://www.mnwelldir.org/docs/terrain/gut_bacteria.htm

This is a link to the human microbiome project. You can find many studies on the gut bacteria here.

https://commonfund.nih.gov/publications?pid=16

https://depts.washington.edu/ceeh/downloads/FF_Microbiome.pdf

It is very important to balance our gut bacteria they regulate gene expressions. They are involved with methylation and metabolic pathways. A disruption in them cause problems throughout our bodies. Supposed inherited imperfection are really a lack of certain commensal microbiota. Much of what they claim is genetic can be corrected by getting the correct microbiota.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518434/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267719/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748575/

https://academic.oup.com/nutritionreviews/article-abstract/75/5/374/3752374?redirectedFrom=fulltext

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892391/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448084/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448088/

Obesity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271550/

https://www.ncbi.nlm.nih.gov/pubmed/29142285

https://www.ncbi.nlm.nih.gov/pubmed/28249045

https://www.nature.com/articles/srep08731?error=cookies_not_supported&code=bfc3c947-3825-4a3c-b1d4-18749d295614

Our gut bacteria is important for bone health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4887186/

Many diseases can be link to our gut bacteria.

https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1111/nyas.13416

Inflammation

https://www.ncbi.nlm.nih.gov/pubmed/24533976

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744517/

Diabetes.

https://www.ncbi.nlm.nih.gov/pubmed/24533976

https://www.ncbi.nlm.nih.gov/pubmed/24325907

The microbiome in our guts is what causes chronic illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339702/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500982/

Our emotions

https://www.ncbi.nlm.nih.gov/pubmed/28533660

https://www.ncbi.nlm.nih.gov/pubmed/28164854

https://www.ncbi.nlm.nih.gov/pubmed/27924137

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179073/

https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(13)00008-8

Correcting autism

http://www.healourlittleones.com/?p=837

https://www.cell.com/cell/fulltext/S0092-8674(16)30730-9

Our gut bacteria regulate our circadian rhythm.

https://kresserinstitute.com/gut-circadian-rhythm-connection/

The list of things modulate by our gut bacteria goes on and on.

Our gut bacteria regulate our immune system especially in our lungs. We have a gut lung axis.

https://www.ncbi.nlm.nih.gov/pubmed/21412185

https://www.sciencedaily.com/releases/2010/06/100614171907.htm

http://pediatrics.aappublications.org/content/121/Supplement_2/S115.2

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397731/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337124/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902499/

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0921-4

https://www.nature.com/news/the-nose-knows-how-to-kill-mrsa-1.20339

https://www.sciencedirect.com/science/article/pii/S0300908411001441?via%3Dihub

Our gut bacteria train our immune system to impart immunity.

https://www.ncbi.nlm.nih.gov/pubmed/29338074

https://www.ncbi.nlm.nih.gov/pubmed/18990206

https://www.ncbi.nlm.nih.gov/pubmed/29142211

http://www.jimmunol.org/content/198/2/572

Many in science still have not come to realized this. They believe that B Cells and T cells are involved in our developing immunity even though this has been proven false many times.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359130/

Breast feeding is also important because the mother imparts immunity to the child this way.

https://www.ncbi.nlm.nih.gov/pubmed/12850343

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902239/

If a child does not get a variety of bacteria early in life they will become prone to chronic illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674690/

Our gut bacteria protect us from pathogens. We have commensal bacteria related to the pathogens. The commensal protect us from their cousins. Many are lacking E Coli Nissle 1917. Also bacteria in our nasal cavities and other areas of the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572226/

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0107758

http://iai.asm.org/content/77/7/2876.full

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988121/

They protect us from urinary tract infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684288/

Our gut bacteria protect us from inflammation

https://www.ncbi.nlm.nih.gov/pubmed/29532517

Our metabolic issues can effect our gut bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083503/

http://mbio.asm.org/content/5/6/e01817-14.short

Your gut bacteria regulate your body mass.

https://www.cell.com/cell/fulltext/S0092-8674(14)01241-0

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0117851

Infants get their microbiome from their mother and environment.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751348/

https://www.youtube.com/watch?v=ElI5q0BWKv0

The western diet has caused many species of bacteria we need to keep us healthy. With the antibiotics, and farm chemicals many species of bacteria that preserve our health is now extinct in the US.

https://www.nature.com/articles/nature16504?foxtrotcallback=true

https://www.nature.com/articles/nature14232

https://www.ncbi.nlm.nih.gov/pubmed/27812084

There is even evidence that our bodies and gut bacteria are meant to eat a seasonal diet.

https://www.newscientist.com/article/2145275-eat-a-seasonal-diet-and-your-gut-microbes-may-change-in-sync/

This is a review of the effects of synbiotics, probiotics and prebiotics.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622781/

Our gut bacteria determine if we are happy and mentally healthy.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040025/

https://www.ncbi.nlm.nih.gov/pubmed?term=Cell[Jour]+AND+2013[pdat]+AND+Hsiao[author]&cmd=detailssearch

https://academic.oup.com/emph/article/2015/1/106/1796013

Strokes have been tied to our gut bacteria.

https://www.nature.com/articles/nature22075

Autism has been linked to our guts.

https://www.bcm.edu/news/pathology-and-immunology/study-connection-between-antibiotics-austism

http://theautismintensive.com/interviews/james-adams-phd/

Mental illness has been linked to our guts.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879184/

https://www.ncbi.nlm.nih.gov/pubmed/29930222

https://www.ncbi.nlm.nih.gov/pubmed/18283240

Liver disease is from inherited gut bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622747/

https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.25704

https://www.ncbi.nlm.nih.gov/pubmed/23873346

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780381/

When born by C section the infant does not get the beneficial bacteria.

https://www.nature.com/articles/nm.4039

Many toxins in our foods especially BT Toxin, glyphosate and glufonisate can inhibit FUT2. This is an enzyme that we secrete that keeps our gut bacteria healthy. Medications like fluoroquinolones can slo inhibit it along with endotoxins from pathogens and afloxin from fungus. This causes food intolerances, food allergies and chronic illness from gut dysbiosis which produces high sulfite and hydroxy radicals which raise ammonia levels in the bladder and digestive system. Ammonia alkalizes our bladder and digestive system. It should be acidic to prevent pathogens. Candida and H Pylori are normally commensal but when we become alkaline they become pathogenic. Also many pathogens prefer an alkaline enviroment. This also leads to gluten, milk and protein intolerance.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800993/

https://experiencelife.com/article/get-smart-about-antibiotics/

https://detoxproject.org/glyphosate/glyphosate-and-roundup-negatively-affect-gut-bacteria/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/

https://realfoodforager.com/glyphosate-an-assault-on-your-microbiome/

https://www.nature.com/articles/ismej20073

https://link.springer.com/article/10.1007/s00284-012-0277-2

https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-016-0294-z

http://www.discoverymedicine.com/Paul-D-Cotter/2012/03/15/the-impact-of-antibiotics-on-the-gut-microbiota-as-revealed-by-high-throughput-dna-sequencing/

http://www.anh-usa.org/genetically-engineered-food-alters-our-digestive-systems/

Antibiotics and farm chemicals are causing more virulant pathogens.

http://mbio.asm.org/content/6/2/e00009-15

Not only that but there is the possibility of the transgenes of the GMOs transferring to our gut bacteria making them into a pesticide factory.

http://responsibletechnology.org/gmo-education/section5/

Oligosaccharides help when someone is not producing FUT2 enzymes.

http://www.newhope.com/ingredients/oligosaccharides-revealing-more-health-benefits

https://nutritionfacts.org/2013/01/10/boosting-gut-flora-without-probiotics/

If we get the correct nutrients our gut bacteria will produce non toxic antibiotics for us.

https://www.jyi.org/2017-march/2017/5/1/addition-of-zinc-manganese-and-iron-to-growth-media-triggers-antibiotic-production-in-bacterial-isolates-from-the-lower-atmosphere

https://www.scientificamerican.com/article/fiber-famished-gut-microbes-linked-to-poor-health1/

Our gut bacteria protect each other and secrete and enzyme that protects them from Reactive Oxygen Species. When the above mentioned causes a loss of those bacteria then the other gut bacteria is defenseless and also dies.

http://europepmc.org/articles/PMC4567566

Toxins also damage our tight junction layer in our guts letting food particles enter our blood stream along with toxins that would usually be inhibited by the tight junction protein layer.

https://www.youtube.com/watch?t=2033&v=Ea-VzpdKwrc

E Coli Nissle 1917 regulates our tight junction protein layer. E Coli

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156689/

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1462-5822.2006.00836.x

Our gut bacteria protect us from oxalates. If they get high we become prone to kidney stones and chronic illness.

https://www.ncbi.nlm.nih.gov/pubmed/20602988

https://www.ncbi.nlm.nih.gov/pubmed/20224931

https://www.hindawi.com/journals/bmri/2013/280432/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300857/

https://www.sciencedirect.com/science/article/pii/B9780323527255000174

When H Pylori is commensal it prevents allergies and inflammation.

https://m.jci.org/articles/view/45041

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548235/

http://www.townsendletter.com/June2013/helico0613.html#.WM1yDBl_6Pw.facebook

We also have protozoa that are part of our gut microbiome and protect us.

https://www.nature.com/articles/srep25255

Our gut bacteria protect us from toxins. So if we are lacking them we lose that protection.

https://www.researchgate.net/publication/312447778_Lactobacillus_plantarum_CCFM639_can_prevent_aluminium-induced_neural_injuries_and_abnormal_behaviour_in_mice

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151190

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770549/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243131/

Our gut bacteria has been linked to TMAO disorder. Fish smell disorder. Causes the urine and body odor to have a fishy smell.

http://mbio.asm.org/content/6/2/e02481-14.full

Eating the right foods reduces TMAO.

https://www.cell.com/cell/fulltext/S0092-8674(15)01574-3?code=cell-site

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817264/

High TMAO levels can cause chronic illness.

https://link.springer.com/article/10.1007/s10157-015-1207-y

https://www.ncbi.nlm.nih.gov/pubmed/21778036

Vaccinations cause a change in our protective bacteria making us lose protection from illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678663/

Our gut bacteria has been linked to liver disease.

https://www.sciencedirect.com/science/article/pii/S2212877816300564

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835615/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229528/

If the bacteria get out of balance bladder dysbiosis can develop resulting in interstitial cystitis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300856/

https://www.nature.com/articles/srep26083

Viruses are a part of our commensal microbiome and help protect us.

https://www.ncbi.nlm.nih.gov/pubmed/29378882

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923452/

http://jvi.asm.org/content/89/4/1951.full

Lacking certain gut bacteria is the reason we get food poisoning.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198571/

We have commensal yeast. Taking this one helped me a lot.

https://www.healio.com/gastroenterology/irritable-bowel-syndrome/news/online/{bb454dd3-01bf-4720-a01e-912c62d09062}/probiotic-yeast-improves-abdominal-pain-bloating-in-ibs-c-patients

We have friendly fungus that protects us.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332855/

Our gut bacteria protect us from cancer.

https://www.ncbi.nlm.nih.gov/pubmed/26884164

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000254/

https://medicalxpress.com/news/2017-09-probiotics-treatment-colon-cancer.html

Our gut bacteria regulate our T cells which would prevent autoimmunity and allergies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983956/

https://www.ncbi.nlm.nih.gov/pubmed/25157157

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833122/

http://iai.asm.org/content/86/4/e00934-17.long

Our diet effects our gut bacteria and vice versa.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544775/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535385/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672356/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852779/

This in turn effects our health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896394/

Spore based probiotics help heal leaky gut. So does E Coli Nissle 1917.

https://www.wjgnet.com/2150-5330/full/v8/i3/117.htm

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156689/

Even our oral microbiome can effect the health of our whole body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346134/

https://www.ncbi.nlm.nih.gov/pubmed/26838600

https://www.ncbi.nlm.nih.gov/pubmed/27778343

Our gut bacteria has been linked to MS.

https://www.nature.com/articles/ncomms12015

Our gut bacteria has been linked to chronic fatigue syndrome.

https://www.sciencedaily.com/releases/2016/06/160627160939.htm

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-016-0171-4

Notice the metabolic pathways in this study are all ones that are regulated by our gut bacteria.

http://www.pnas.org/content/113/37/E5472.short

Gut bacteria regulate our cholesterol levels.

https://link.springer.com/article/10.1007%2Fs13167-017-0117-3

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904929/

They use scare tactics to get us to fear viruses but they also protect us.

https://www.asm.org/index.php/asm-newsroom2/press-releases/93495-viruses-you-ve-heard-the-bad-here-s-the-good

Now the part that kind of creeped me out. Even parasitic worms can be used to heal the gut.

https://www.nourishingplot.com/2017/05/23/beneficial-worms-and-bacteria-for-a-healthy-microbiome/

http://science.sciencemag.org/content/352/6285/608

Our gut bacteria will produce vitamins for us if we give them the right nutrients.

https://www.sciencedirect.com/science/article/pii/S0308814617308154?via%3Dihub

https://link.springer.com/article/10.1007%2Fs00394-017-1445-8

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605934/

https://hsrc.himmelfarb.gwu.edu/smhs_microbio_facpubs/295/

https://nutritionsciencefactcheck.com/2014/12/28/the-metabolism-of-plant-lignans-via-human-intestinal-microbiota/

Probiotics help with aging.

https://www.hindawi.com/journals/bmri/2017/5939818/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156754/

Some gut bacteria feed others.

https://www.nature.com/articles/srep13548

Our appendix houses backup stores of our microbiome. Antibiotics kill them making us more prone to appendicitis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769896/

Appendectomies increase our risk of kidney disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004103/

Appendectomies increase our risk for infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447260/

https://www.ncbi.nlm.nih.gov/pubmed/17936308

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011360/

Things that help with IBS.

https://www.hindawi.com/journals/mi/2015/628157/

A link to a study earlier mentioned how our microbiome regulate our zonulin levels. When things get through out of wack it can effect the whole body .

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214347/

Herbal therapy has been shown to be very effective against SIBO. This would keep the good gut bacteria from being killed by antibiotics.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030608/

Gut dysbiosis can result in gall stones.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851472/

It can also result in cardiovascular disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579652/

If we do not get enough fiber our gut bacteria will digest our mucous membrane making us prone to infection.

https://www.cell.com/cell/fulltext/S0092-8674(16)31464-7

Our gut bacteria is even linked to our endocanabinoid system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925525/

Drink a little red wine and our gut bacteria will lower oxLDL.

https://www.ncbi.nlm.nih.gov/pubmed/25738317

Our gut bacteria is involved in the regualtion of bile acids. If we do not get enough bile we get constipate to much bile and we will get diarrhea.

https://www.ncbi.nlm.nih.gov/pubmed/7288282

https://rd.springer.com/article/10.1007/BF02773728

Bile acid issues have been connected to NAFLD.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874546/

Those with sickle cell have gut dysbiosis.

https://sicklecellanemianews.com/2017/11/16/study-links-pain-in-sickle-cell-disease-to-increase-in-a-type-of-gut-bacteria/

Candida Myths busted.

There are many myths about candida for example you should alkalize the body to fight it. If you do that you will feed it and many other pathogens. Our bladder and digestive system is supposed to be acidic. When you alkalize them which is very hard then you would be feeding candida. When we get high ammonia levels from metabolic issues or from gut dysbiosis it alkalizes our bladder and digestive system causing candida to go from a friendly fungus we need to a pathogenic form. To get it back to the friendly form we need to fix the metabolic issues or the any other number of issues that can cause high ammonia levels. Once Candida is in the pathogenic form it will raise the PH to an alkaline one and it does it in a very short period of time.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101780/#

https://www.theguthealthprotocol.com/wp/the-alkalizing-myth

https://academic.oup.com/femsyr/article/15/7/fov081/641997

https://link.springer.com/chapter/10.1007/978-1-4757-3021-0_18

https://www.candidaplan.com/10-candida-myths-2/

https://restormedicine.com/digestive-health-candida/

If you are dealing with candida brewers yeast helps a lot. Candida is not in the yeast family, that is another myth that if you eat yeast you will feed candida. The opposite is true, brewers yeast gets candida back to commensal.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354225/

Burdock root also helps with candida.

https://www.yeastinfectionadvisor.com/burdockroot.html

I used the things in this article and they also helped.

http://naturalsociety.com/suffering-candida-overgrowth-signs-prevention-solutions/

Mushrooms help with candida.

https://owndoc.com/candida-albicans/mushrooms-fungi-molds-candida/

Biotin helps with candida.

http://ericbakker.com/biotin-for-candida/

Uva Usa helps with a lot of things but I have not had a chance to research the safety of long term or high does usage.

https://www.sigmaaldrich.com/life-science/nutrition-research/learning-center/plant-profiler/arctostaphylos-uva-ursi.html?cm_mmc=SocialSharing-_-Facebook-_-Links-_-/content/sigma-aldrich/global-home/global/en/life-science/nutrition-research/learning-center/plant-profiler/arctostaphylos-uva-ursi

There is a lot of confusion concerning candida and gut dysbiosis.

http://www.holistichelp.net/blog/candida-sibo-or-h-pylori/

Nutrients needed when fighting candida.

http://www.orthomolecular.org/library/jom/1985/pdf/1985-v14n01-p050.pdf

http://www.ei-resource.org/articles/candida-and-gut-dysbiosis-articles/the-candida-aldehyde-detox-pathway-and-the-molybdenum-connection/

Candida can cause sugar cravings.

http://www.arltma.com/Newsletters/SugarCarbNews.htm

Omega 3 is needed but Omega 6 must be avoided to prevent endotoxemia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650612/

These links speak about the benefits of various probiotics.

http://salernocenter.com/2012/10/probiotic-benefits/?utm_campaign=shareaholic&utm_medium=facebook&utm_source=socialnetwork

https://www.statnews.com/2016/04/15/drugs-gut-microbiome

http://mbio.asm.org/content/6/2/e02481-14.full

Microbiome is transferred between sexual partners.

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-016-0161-6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225992

https://academic.oup.com/aje/article/156/12/1133/151795/Uropathogenic-Escherichia-coli-Are-More-LikelyUropathogenic-Escherichia-coli-Are-More-Likely

http://ispub.com/IJID/8/2/6466

Our diet can change our gut microbiome and cause inflammation.

https://www.ncbi.nlm.nih.why-yogurt-and-probiotics-make-you-fat-and-foggywhy-yogurt-and-probiotics-make-you-fat-and-foggy

https://www.ncbi.nlm.nih.gov/pubmed/2current

https://www.ncbi.nlm.nih.gov/pubmed/21497805

Some microbiome can cause weight gain.

https://blog.bulletproof.com/why-yogurt-and-probiotics-make-you-fat-and-foggywhy-yogurt-and-probiotics-make-you-fat-and-foggy

There are probiotics that increase hormones such as oxytocin which helps with depression and healing.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809651

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597586

https://www.ncbi.nlm.nih.gov/pubmed/abstract

https://www.ncbi.nlm.nih.gov/pubmed/25803901

https://www.ncbi.nlm.nih.gov/pubmed/24021287

You have to balance your gut microbiota. To much of one or another can cause problems.

http://www.probioticscenter.org/bloating-and-probioticsgov

if we lose some strains of bacteria it can cause TMAO disorder.

http://mbio.asm.org/content/6/2/e02481-14.full

These are the probiotics that help me with my dairy issues.

http://www.sciencedirect.com/science/article/pii/S0023643812000503

http://www.sciencedirect.com/science/article/pii/S0963996912000890

http://pubs.acs.org/doi/abs/10.1021/acs.jafc.6b00714?journalCode=jahttp

For those with interstitial cystitis and urinary issues you need the right probiotics.

https://www.hindawi.com/journals/au/2009/680363

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285709

http://www.tandfonline.com/toc/zmeh20/current

I had difficulty eating fruit. Probiotic yeast helped correct that.

https://www.healio.com/gastroenterology/irritable-bowel-syndrome/news/online/%7Bbb454dd3-01bf-4720-a01e-912c62d09062%7D/probiotic-yeast-improves-abdominal-pain-bloating-in-ibs-c-patients

Our gut microbiota protects us from toxins.

https://www.researchgate.net/publication/312447778_Lactobacillus_plantarum_CCFM639_can_prevent_aluminium-induced_neural_injuries_and_abnormal_behaviour_in_mice

Peroxisomes help recycle reactive oxygen species which protects our cells from damage. Some microbiome produce peroxisomes.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0117851

Many food additives has negative effects on the gut microbiome which effects the body.

http://www.nature.com/nature/journal/v519/n7541/full/nature14232.html

You have to balance your gut microbiota. To much of one or another can cause problems.

http://www.probioticscenter.org/bloating-and-probioticsgov

Because our microbiome regulates gene expression antibiotics that kill our gut microbiome causes gene damage.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339702

Our microbione regulates inflammation in our bodies.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744517

Some protect us from tick born illness.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097911

Antibiotics and toxins also destroy the gut microbiome that protects us from pathogens.

http://www.discoverymedicine.com/Paul-D-Cotter/2012/03/15/the-impact-of-antibiotics-on-the-gut-microbiota-as-revealed-by-high-throughput-dna-sequencing

https://detoxproject.org/glyphosate/glyphosate-and-roundup-negatively-affect-gut-bacteriaglyphosate-and-roundup-negatively-affect-gut-bacteria

Those prone to urinary tract infection have been shown to have a microbiome imbalance.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684288

http://m.pnas.org/content/111/36/13145.absshort

https://www.ncbi.nlm.nih.gov/pubmed/21412185

They protect us from cavities.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346134

Some microbiome make vitamins that are needed.

https://www.ncbi.nlm.nih.gov/pubmed/2855html

They falsely claim some bacteria are pathogenic but they are needed to protect us.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988121

http://mbio.asm.org/content/5/6/e01817-14.short

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0107758

https://www.ncbi.nlm.nih.gov/pubmed/21778036

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC414html

Gut dysbiosis is a major cause of arthritis

https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-014-0486-0

Our bodies secrete an enzyme FUT2 that keeps our microbiome healthy. It also helps modulate our immune system. Many things now days can inhibit this enzyme and in some completely disable their ability to produce FUT2 Enzymes. The result can be autoimmune dysfunction and we will not be able to establish a healthy colony of gut microbiome.

http://www.nature.com/ismej/journal/v8/n11/full/ismej201464a.html

http://www.traceyreed.ca/blog/2016/4/12/fut2s-role-in-gut-healths-role-in-gut-health

There are two things that help with a FUT2 non secretor. Take a symbiotic that contains an ologosaccharide or a probiotic that produces What you need.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800993

http://www.newhope.com/ingredients/oligosaccharides-revealing-more-health-benefitsoligosaccharides-revealing-more-health-benefits

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516493

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840232

Here is a good article on various diseases and microbiota.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351195

The probiotic we use has to be unique to what issues we are dealing with.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156804

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760697

https://www.ncbi.nbloating-and-probioticsgov

Probiotics and cancer. It is better to prevent cancer. Many who have cancer have been found to have acidosis which indicates an underlying health is. That can be from metabolic issues, leaky gut, toxins especially heavy metals and the BT Toxins found in GMOs and the herbicide used on it glyphosate. All those can cause leaky gut which can cause high histamines which also leads to acidosis. Cancer has also been found to create it’s own micro acid environment. Keeping our gut balanced protects us from cancer and many other illnesses. This can also lead to acidosis from dybiosis or akalosis (hyperammonemia)from fungal infection which also causes cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397731

Even type 1 diabetes has been linked to the gut.

https://www.sciencedirect.com/science/article/pii/S1931312815000219

Opium Lettuce helps with spastic colon.

http://europepmc.org/articles/PMC3638630

Those who have issues with their digestion that causes the food to sit and ferment instead of digesting properly my not want to use apple cider vinegar. It delays digestion even more.

https://www.ncbi.nlm.nih.gov/pubmed/18093343

https://www.sciencedirect.com/science/article/pii/S0378874106001565?via%3Dihub

 

Healing Interstitial Cystitis.

Written by Lee Stevenson, sorry I am not a very good editor.

I still have a lot of things to ad but I have decided to put all the research I did when I was working on healing on one web page. Hope it helps.

This is not medical advice and should not be taken as such. It is for informational and educational purposes only. Please find a qualified naturopathic doctor with a proven history of good work. Allopathic medicine only treats the symptoms, naturopathic treats the cause. For reasons I don’t have time to discuss I do not like homeopathy although it does have some good things.

It takes a lot of research and self discipline to get into remission from interstitial cystitis but I know it can be done because I can eat and do many things now. When I do have flare ups they do not last more then a day or two. For the most part the things that help me have become a habit and a part of my life so I forget I have it sometimes unless I eat some GMOs or a lot of sugar or something else I shouldn’t be eating.

The key to healing from IC is finding what the triggers were. I do know those who got the Covid vaccine are experiencing IC. Vaccines have been known to cause IC in the past. GMO foods also cause IC from the metabolic, mitochondrial issues and the farm chemicals they spray on them. IC can be caused by infection. Forskolin gets the infection out of tissue but a person still has to kill the infection. Some can have an overgrowth of lactobacillus which is called a cytosolic infection. Many medications especially fluoroquinolones can cause IC. Each has to be addressed by the causes. There is usually more then one factor that leads to IC, it is a synergistic effect of things coming together. But the Covid vaccines seem to be causing IC with no other comorbities.

Excess Oxidative stress leads to chronic illness there is a test to see if you have excess oxidative stress. If you do not get it resolved you cannot heal. You can get a test to check oxidative stress levels.

https://www.ichelp.org/oxidative-damage-may-give-clues-to-icbps-diagnosis/

There are other test that can help identify which areas of the anti-oxidant system are working and which may not be working. This can help identify the sources of high ROS levels or other toxins produced in the body from oxidative stress.

https://drjockers.com/oxidative-stress-test/

https://www.sciencedirect.com/science/article/pii/S0009898103004534

If you have bladder issues and are not certain what the problem is this is a pdf you can download that is a symptom profile for interstitial cystitis.

https://www.mdedge.com/jfponline/article/64347/womens-health/when-suspect-interstitial-cystitis

Interstitial Cystitis can be put in remission. There are many causes like toxins in our environment, pathogens. Mine is caused by Lyme disease. There are studies that have shown that up to 80% of those with interstitial cystitis have tick born illness. Vaccine injury is also a cause of interstitial cystitis. BT Toxins in GMOs and the glyphosate used on them can cause interstitial cystitis. I will try to list links to sources to show the claims I make. These links list the possible causes. When we get an infection in the bladder it sheds and raises histamines and inflammation. This tell the body there is a problem and it will send an all out attack to try and get rid of pathogens or whatever is causing the problem. In those with interstitial cystitis the bladder get stuck in this cycle and the key is getting the inflammation down and getting the brain to believe that things are ok. That is why it is very important to address mental issues, health issues and reduce the inflammation, histamines and pain so the cycle can be stopped.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908978/

https://lymemd.blogspot.com/2009/06/interstital-cystitis-and-lyme.html?m=1

GP51 glycoprotein has been found to be deficient in those with IC. This causes the bladder to get stuck in a shedding and repair state. I have found adding source of glycoprotein to my diet helped me a lot. I did herx at first because glycoproteins also help kill pathogens.

https://www.ncbi.nlm.nih.gov/pubmed/10332435

https://tasteforlife.com/retail-partners/health-guide-conditions/interstitial-cystitis

https://www.frontiersin.org/articles/10.3389/fnins.2012.00114/full

https://www.ic-network.com/lyme-disease-interstitial-cystitis/

https://www.ncbi.nlm.nih.gov/pubmed/22310775

https://www.voiceamerica.com/episode/60968/is-there-a-connection-between-interstitial-cystitis-and-lyme-disease

Each persons IC is unique and has to be addressed according to their health issues. There is no a one size fits all protocol.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798639/

I will list things that have helped my friends and I at the end of this article.

Each of us is unique we have to figure out the cause. Many of us have metabolic issues like inhibited sulfation or upregulated CBS or BH4 pathways which causes interstitial cystitis. All this can be caused by toxins, endotoxins from infection and the toxins in vaccinations which stay in the body for years. The key to going into remission is figuring out what our metabolic and immune issues are and addressing them. Many of the things I mentioned cause leaky gut so it must be healed. All the things I mentioned above cause high oxalate levels so we must watch our oxalate intake. Also high doses of vitamin C and vitamin D can cause oxalates so we must do those in moderation. Most recommend we do not do over 4000 IU of vitamin D a day. Because our skin can make vitamin D from sun light life guards have the highest incidence of kidney stones. Sun light is good and needed but do not over do it.

That being said I am going to list sites of people who have gotten their IC into remission. The reason I say remission many I know who have recovered still have temporary short term episodes but because we have learned how to recover they do not last long. So I believe we never fully get rid of IC.

http://www.icsuccessonline.com/Bill.htm

http://ezinearticles.com/?Interstitial-Cystitis—Ayurvedic-Herbal-Treatment&id=8161824

Many of the things in this article helped me but you must make sure they are organic. There are many herbicide and pesticide residues on and in foods now and they will make us much worse. To learn more read my post on GMOs.

https://naturallyhealthynews.com/articles/healtharticles/understand-interstitial-cystitis/#comment-15991

Many articles will mention cranberry but most IC sufferers have high oxalates and we must try our best to consume low oxalate foods. D-Mannose in cranberries does help the bladder and you can buy it as a separate supplement. I do not recommend cranberry juice for any bladder issues because of it’s oxalate content. Also it has a high acid level and many IC sufferers have acidosis. The things mentioned in the article below have helped many but they do promote cranberry juice which could cause problems in the bladder. When you see articles that mention cranberry juice take it with a grain of salt.

https://hubpages.com/health/Interstitial-Cystitis-Life-Without-Pain

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1476005/

Here is a list of the oxalate content of food. Remember we cannot completely avoid them but this knowledge can help us to avoid them.

http://www.wakehealth.edu/Urology/Kidney-Stones/Oxalate-Content-of-Foods.htm

This is a list of links to research of things that help with IC.

https://www.ichelp.org/research/literature-reviews/basic-research/

Diet changes that may help with IC.

http://www.todaysdietitian.com/newarchives/020314p34.shtml#.VzBtd2Pa_P0.facebook

Those who have IC usually also have fibromyalgia, the mechanisms that trigger it are the same.

https://www.ncbi.nlm.nih.gov/pubmed/9201654

https://www.ncbi.nlm.nih.gov/pubmed/17462477

All who have interstitial cystitis have mast cell activation issues. Which is also common in fibromyalgia.

https://palmitoylethanolamide4pain.com/about-2/cystitis-natural-treatment/5550-2/

https://www.ncbi.nlm.nih.gov/pubmed/26763911

https://www.ncbi.nlm.nih.gov/pubmed/9915421

Some have had good results at lowering histamines with Pentosanpolysulfate but you have to make sure you do not have sulfation issues before using it.

https://www.ncbi.nlm.nih.gov/pubmed/11061939

Studies have found that those with interstitial cystitis have an imbalance in their gut bacteria.

https://www.nature.com/articles/srep26083

Hydrangea root helps with TH17 imbalance which is common in those with interstitial cystitis and psoriasis.

https://www.medicalnewstoday.com/articles/152822.php

Bradykinins contribute to IC, grape seed extract reduces bradykinins.

https://www.ncbi.nlm.nih.gov/pubmed/10379755

Studies have shown many IC sufferers are low in vitamin D. I would not take over 4000 IU of vitamin D because studies have shown doses higher then that cause oxalates to form. Also make sure you use natural vitamin D man made vitamin D has been found to cause many negative side effects.

http://www.sciencedomain.org/abstract/687

Many of the species of bacteria that cause IC cannot be detected. These types are usually found in rivers and lakes. If our Acidophilus bacteria is low we lose the protection they give. Antibiotics kill our good bacteria which would make us lose protection.

https://www.sciencedirect.com/science/article/pii/S0022534701682375

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126088/

Vaccinations damage the HPA which is found to be common in IC.

https://www.jurology.com/article/S0022-5347(05)61144-5/abstract?cc=y

Many have said the supplement CystoProtek has helped them.

https://www.ncbi.nlm.nih.gov/pubmed/19046494

Epigallocatechon Gallate helps with IC unfortunately many of the foods that contain them are also high oxalate or high histamine. Green Tea if consumed in high quantities can raise histamine levels. Also get organic and from countries that have strict environmental laws. Tea from China has been found to be high in heavy metals and cadmium. Their are many pesticides and herbicides found on non organic teas.

https://www.ncbi.nlm.nih.gov/pubmed/23260235

Sources of EPCG, I got mine from nuts like walnuts and hickory nuts and beans especially legumes like peas.

http://ampkactivator.net/epigallocatechin-gallate/

Green tea can be hepatotoxic if consumed in high amounts. So moderation is the key with green tea.

https://www.sciencedirect.com/science/article/pii/S0273230018300928?via%3Dihub

https://www.nutraingredients.com/Article/2018/04/19/EGCG-warning-EFSA-safety-assessment-suggests-green-tea-supplements-should-come-with-warning

Leaky gut, toxins especially aluminum in vaccines, fluoroquinolones, glyphosate and glufosinsate can cause glycosylation issues. This has been found to be a problem in IC.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1464-410X.2008.08163.x

Vaccinations, tick born illness and toxins like fluroquinolones, fluoride, lead and mercury can raise substance P levels. The symptoms are burning in the skin, especially in the scalp area and down the spine. Burning or tingling nerves. Substance P increases at night so symptoms get worse at night. If levels get too high it can cause the body to start attacking itself. Feverfew, chamomille, daisy and baking soda lower substance P.

https://onlinelibrary.wiley.com/doi/full/10.1046/j.1464-410X.1998.00507.x

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1886652/

Mycoplasmas are hard to detect and can cause problems. Up to 80% of vaccinations are believed to be contaminated with mycoplasmas.

https://drfredlim.blogspot.com/p/viewpoint-on-ureaplasma-mycoplasma.html?m=1

I know it is hard to get over the trauma of our past and things that may have happened through our life. But studies have shown trauma can cause interstitial cystitis. It is very important to let negative things that have happened in our lives make us stronger. If not then the one who caused the trauma still has control by mentally victimizing us over and over again in our minds. We need to take that back and not give anyone that kind of power.

https://www.ncbi.nlm.nih.gov/pubmed/19863855

https://www.ncbi.nlm.nih.gov/pubmed/28107899

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067184/

When you have gotten all things addressed the histamines, mast cells, metabolic issues , inflammation and high substance P levels and learned to deal with stress and past trauma and the IC is still present then the brain is stuck in the shed and repair cycle. This can be caused by the pain in the bladder it signals the brain something is wrong. Many have had success with botulin toxin. It numbs the bladder for a while giving the brain time to reset. Some IC can be caused by spinal cord injury. This may help with that also.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963834/

https://www.ncbi.nlm.nih.gov/pubmed/27249005

http://www.icawareness.org/ic-awareness-month-daily-fact-22-interstitial-cystitis-and-botox

Cox is over expressed in those with IC. Natural COX inhibitors help reduce the severity of IC it is also a common cause of leaky gut and is why many with IC have digestive issues. Inflammation also causes over expression of COX.

https://www.ncbi.nlm.nih.gov/pubmed/26057882

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461170/

APF was found to be high in those with IC. I research this and found that lacking certain commensal bacteria ,inflammation and high histamines caused this. By using a suppository made of coconut oil with the strain of bacteria needed many found relief. It is also why many with IC have vulvadynia. Oxalates also will cause vulvadynia.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC511055/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708545/

http://europepmc.org/articles/PMC1939966

mTOR is usually high in chronic illness. They have found that reducing mTOR helps alleviate the symptoms of interstitial cystitis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084610/

How to inhibit mTOR.

https://www.selfhacked.com/blog/mtor-natural-mtor-inhibitors/

This study showed that real life experiences where more accurate then clinical research on finding effective treatments.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783700/

https://www.hindawi.com/journals/crim/2014/698758/

Many have had good result with cannabinoids but with the metabolic issues I have it made me worse.

https://www.researchgate.net/publication/260374234_Evaluation_of_selective_cannabinoid_CB1_and_CB2_receptor_agonists_in_a_mouse_model_of_lipopolysaccharide-induced_interstitial_cystitis?utm_source=facebook&utm_medium=rgShare&utm_campaign=shareFullTextPublication

High adrenaline levels can be caused by many toxins especially GMOs and the toxins used on them. This can result in IC.

https://onlinelibrary.wiley.com/doi/abs/10.1002/nau.22542

This is a study of the many issues that can effect the bladder. It also shows why so many are effected differently and each has a variety of different symptoms.

https://www.hindawi.com/journals/bmri/2014/297295/

Environmental factors determine who will be prone to IC more then genetics.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442798/

Many who have IC have been found to be deficient in Cathelicidin. This is why vitamin D helps with IC. For those who are not converting their vitamin D to D3 you may want to supplement with D3 instead.

https://academic.oup.com/jid/article/211/7/1164/2910517

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659525/

Cathelicidin deficiency inhibits our ability to fight pathogens. GMOs, fluoride,fluoroquinolones,mercury, lead, aluminum,glyphosate and glufosinsate inhibit our ability to convert vitamin D which would result in an inability to fight infection. Those who have high levels of these substances may benefit from taking vitamin D3.

https://www.hindawi.com/journals/jir/2018/7357162/

https://bmcresnotes.biomedcentral.com/articles/10.1186/1756-0500-5-575

Butyrate found in butter and ghee and produced when we eat inulin (hard to digest fiber) increases Cathelicidin.

http://iai.asm.org/content/85/3/e00905-16.full

If you do not get inflammation addressed then your ability to make Cathelicidin will be inhibited no matter what your vitamin D status is.

https://www.karger.com/Article/FullText/339149

If the ability to produce Cathelicidin is not inhibited and you are producing too much Cathelicidin then you can develop thrombosis (blood clotting) and will develop more inflammation. Homeostasis is the goal. Do not over do things.

https://www.nature.com/articles/s41467-018-03925-2

TH2 cytokines down regulate Cathelicidin so if you are TH2 dominant you will be deficient in Cathelicidin. This can cause skin issues to develop. So balancing our T cells is important.

http://www.jimmunol.org/content/jimmunol/181/6/3915.full.pdf

Vaccine injury can raise zonulin levels, leaky gut caused by GMOs and toxins can also raise zonulin levels which can lead to IC. Also antibiotics and glyphosate can kill our good gut and bladder bacteria which regulates our tight junction protein layers which leads to IC. So in other words modern processed food can lead to IC. To find out more on GMOs look at my post on them.

https://www.verywellhealth.com/ibs-and-interstitial-cystitispainful-bladder-syndrome-1945197

https://www.ncbi.nlm.nih.gov/pubmed/24662556

Chemicals especially farm chemicals on our food, drugs especially fluorquinolones and many toxins can cause inflammation in the bladder which causes endothelin-1 over expression. This can lead to interstitial cystitis. If you look at IC research many of the things found in our foods and given as medication is used to cause ischemia-reperfusion in lab animals. This causes blood flow in the bladder to be disrupted which leads to IC. Endothelin-A agonist helps reduce the severity but it will not get rid of the problem. It is not mentioned in this study but Endothelin-A is a protein in a family that encodes histone acetyltransferases (HATS) and plays an important role in chromatin remodeling which is involved in DNA remodling and cell apoptosis (death) . Histones play a role in cell cycle progression and development. It controls endothelial growth. Over expression of ET-A increases inflammation. Withaferin A decreases ET-1 which may help with the inflammation and over expression of ET-1. Resveratrol found in grapes skins, grape seed extract and wine reduces ET-1.

http://europepmc.org/abstract/med/12187271

https://www.ncbi.nlm.nih.gov/pubmed/25777483

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002015000100106&lng=en&nrm=iso&tlng=en

When chemical induced ischemia-reperfusion has occurred the estrogen and nicotinic pathways work together to reduce inflammation. 17-B-Estradiol and a nicotinic agonist help reduce inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189612/

Glyphosate, glufosinate, vaccine adjuvants, and heavy metals like mercury and lead can cause damge to the NMDA receptor. This has been found to be common in those with IC. I do not like this study because instead of addressing the cause they want to treat the symptoms which seems to be the main them of allopathic medicine. If I get a chance I will do a post on things that help repair the NMDA receptor. Mugwort, olive oil, CoQ10, P5P, and coconut oil have been found to help.

http://inter-use.com/Journals/JSAB/2015/Volume_03_Issue_04/2015/0507/96.html

Some have found that the administration of GAGs have given them temporary relief from IC.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772357/

PI3K and mTor are over expressed in IC. Reducing their expression helps with inflammation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084610/

This is a very good site for information on mTor and how to reduce it.

https://www.selfhacked.com/blog/mtor-natural-mtor-inhibitors/

Milk should be avoided it stimulates mtor.

https://nutritionfacts.org/2016/01/05/how-to-suppress-the-aging-enzyme-tor/

https://articles.mercola.com/sites/articles/archive/2016/05/07/too-much-protein-triggers-aging-cancer.aspx

IC can be mistaken for cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270612/

Thymoquinone found in many spices helps with IC.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971733/

Melatonin helps with IC. Many with Ic have been found to be deficient in melatonin which can be caused by vaccine injury, toxins and even EMFs.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1600-079X.2004.00202.x

Take some of the articles with a grain of salt each of us is different and each of us has foods we have to avoid which is unique to us and our metabolic and digestive issues. I believe the first article is the best I have found it to be the most accurate.

https://i-dream-of-sleep.com/increase-melatonin-production-naturally/

https://lifespa.com/10-ways-boost-melatonin-naturally/

http://www.naturallivingideas.com/boost-melatonin/

PARP inhibition helps with toxin induced bladder injury.

http://journals.sagepub.com/doi/abs/10.3181/0706-RM-151?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed

Querciten and Rutin are inhibitors of PARP

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896521/

Heme Oxygenase 1 expression helps reduce the symptoms of IC.

https://www.ncbi.nlm.nih.gov/pubmed/17979934

Sunlight increases Heme Oxygenase.

https://www.tandfonline.com/doi/abs/10.1080/10715769900300901

Hypoxia increase Heme Oxygenase. This can be accomplished by breathing into a paper lunch bag but if done incorrect could deprive you of too much oxygen and make you pass out. Do research if you try something like that to see how it can be done safely.

https://www.physiology.org/doi/abs/10.1152/ajpcell.2000.278.1.C92?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed

Exercise stimulates HO-1

https://www.hindawi.com/journals/bmri/2018/7212861/

New stuff

Lipoxygenase Inhibitors along with Cox inhibitors. helps with IC that has been induce by toxins or drugs.

https://www.ncbi.nlm.nih.gov/pubmed/12686867

L-arginine improves bladder control for those who have issues with frequent urination. L-arginine increases NO so those who do not have this problems but have high reactive oxygen species this may make them worse.

https://www.karger.com/Article/Abstract/96931

A deficiency in PIRT causes excess bladder voiding.

https://www.nature.com/articles/ncomms8650

Some have to retrain their bladders once the inflammation and other issues have been addressed.

https://www.health.harvard.edu/healthbeat/training-your-bladder

Infection and metabolic issues can cause raised ammonia levels throughout the body and cause a break down of many things. Since the body gets rid of ammonia through the bladder it causes damage to the bladder. The infection or metabolic issue must be addressed.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4546155/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057615/

Toxins like glufonisate and glyphosate used on our crops can cause high ammonia levels which damages many areas of the body especially the nerves which has been link to IC.

https://www.tandfonline.com/doi/abs/10.3109/15563650.2010.539184

The high ammonia levels will cause raised glutamine levels which will give you headaches especially when you consume foods that are high in glutamine. If you are having issues consuming things that contain glutamine you most likely have high glufonisate or glyphosate levels which comes mainly from eating GMOs and foods that have been dried using those toxins.

https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.21357

I eat honey because it is high in zinc and zinc reduces inflammation and ammonia levels.

https://www.ncbi.nlm.nih.gov/pubmed/18054190

Our bladders are supposed to be acidic. Infection can make them alkaline which kills our good bacteria.

https://www.jstage.jst.go.jp/article/jjaam/23/9/23_398/_article

Zinc and Carnosine work together.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852723/

Carnosine also reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4745351/

Infections especially tick born illness can raise ammonia and quinolinic acid.

https://www.longecity.org/forum/topic/87433-quinolinic-acids-relationship-with-lyme-neurodegenerative-and-infammatory-disorders/

Oxidative stress and hyperammonemia can deplete pirt. This causes and over expression of P2X3 which will cause an over active bladder resulting in frequent urination.

https://www.nature.com/articles/ncomms8650

https://www.jstage.jst.go.jp/article/jjaam/23/9/23_398/_article

They are experimenting now with things that reduce P2X3 over expression.

https://pdfs.semanticscholar.org/2b41/b7cf86d99384d18eb95963efa96d9fde75d7.pdf

Antibiotic use is killing our good gut bacteria and may be contributing to the rise in the number of IC cases.

https://www.ic-network.com/dipp-mystery-ic-patients-deficient-bacteria-gut/

Acacia gum helped heal my gut. When we have digestive issues it can cause IC by raising histamines and inflammation in the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763258/

Magnesium Citrate helped me a lot. Magnesium helps reduce inflammation. I used magnesium citrate because it also reduces oxalates. The firs couple of days I took it, it gave me indigestion but the third day I started feeling much better and could not believe how much it reduced my pain. Magnesium citrate should not use often. Our bodies recycle citrate so it can build up in the body. If levels get to high then it can damage the liver , kidneys and red blood cells. Use it in moderation.

http://www.drbriffa.com/2012/04/27/the-natural-remedy-thats-often-effective-for-calming-an-irritable-bladder/

Histamines have been found to be high in those with IC and it is why so many with IC may have mental issues.

https://healinghistamine.com/the-histamine-mast-cell-depression-link/

Melatonin reduces mast cells.

https://healinghistamine.com/melatonin-mast-cells-and-histamine/

Tocotrienols a type of vitmaine E found in palm oil, rice bran oil, wheat germ, barley, saw palmetto and oats lower histamines and substance P. You have to be careful some of those are GMOs and the BT Toxins from GMOs have been found in mothers fetuses and human brains and causes the same symptoms as food poisoning.

https://www.wellnessresources.com/studies/tocotrienol-allergic-dermatitis

Catalase helps restore the antioxident system back to homeostasis but many things that contain it are high sulfur so make sure you do not have sulfation issues. Eating high sulfur foods and meat when you have sulfation issues will make you worse if you do not address it.

http://healthyeating.sfgate.com/vegetarian-sources-catalase-3693.html

Vitamin A deficiency can cause IC

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786935/

Food sources of vitamin A. Always try to get your vitamins from natural sources, many vitamins are synthetic and have been shown to have many side effects especially folic acid it causes cancer and damages the NMDA receptor. Folate which is natural does the opposite.

https://www.globalhealingcenter.com/natural-health/vitamin-e-foods/?gclid=EAIaIQobChMIt9T3p5Le2wIVFVqGCh22_wbNEAAYAyAAEgLu4fD_BwE

https://www.dietitians.ca/Your-Health/Nutrition-A-Z/Vitamins/Food-Sources-of-Vitamin-A.aspx

https://healthwholeness.com/vitamin-rich-foods/vitamin-a-foods

Cat’s Claw helped me. Phytoestrogen has been shown to reduce IC symptoms. Cat’s Claw contains Phytoestrogen is most likely why it helps.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496084/

Some have said honey bush tea has helped them.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817056/

phytoestrogens are why Peuraria Mirifica and Maca root reduce symptoms of IC.

https://www.ncbi.nlm.nih.gov/pubmed/17415017

Malva is in the mallow family. Most plants in the Mallow family reduce inflammation and help heal the gut and tight junction protein layers in the gut and bladder. I grow the cheese plant which is in the mallow family and has the same benefits as marshmallow root.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4590556/

Toxins, vaccine injury, GMOs and stress can increase glutamate levels which can make IC worse. Plants that helped calm me like honeysuckle, yarrow, opium lettuce and wild daisy really helped me a lot.

https://www.ncbi.nlm.nih.gov/pubmed/26697981

Tick born illness and mycoplasma inhibit IL 10, Our bodies use IL 10 to detect infections and rid the body of them. Then it will reduce inflammation. Inhibiting IL 10 causes excess inflammation. This cause the body to be unable to recognize the pathogen. When this happens the body will release hydrogen pyroxide which is a last ditch effect to remove the pathogens from the body. This cause a lot of damage throughout the body. This is why it is important to reduce inflammation and to support the function of IL 10. Hydrogen pyroxide will break down the tight junction layers in the gut, blood brain barrier and bladder. This cause inflammation in all those areas. When the tight junction layer has been effected in the digestive system food allergies and intolerances will develop. Warning increasing IL 10 can lead to weight loss.

http://www.jimmunol.org/content/188/2/781.full

https://www.ncbi.nlm.nih.gov/pubmed/16375698

https://www.selfhacked.com/blog/il-10/

Blocking Tumor Necrosis Factor will upregulate IL 10

https://www.frontiersin.org/articles/10.3389/fimmu.2017.00157/full

Ways to inhibit TNF , they recommend ketosis. That worked great for me but those with type 1 diabetes that can result in death.

https://www.selfhacked.com/blog/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6/

http://www.life-enhancement.com/magazine/article/2428-pain-relief-starts-in-the-brain-blockade-of-tnf-alpha-tumor-necrosis-factor-alpha-inhibits-the-br

http://www.scielo.br/pdf/bjps/v47n3/02.pdf

Lactococcus Lactis found in some cheeses and buttermilk increase IL 10

https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-016-0548-x

Sepsis can result in IC. This is caused from being given too high of a dose of antibiotics which kills of pathogens and fungus to quickly. The body becomes overwhelmed with endotoxins or afloxin resulting in a lot of damage throughout the body.

http://www.sepsis.org/sepsis-and/urinary-tract-infections/

Methylene Blue which can be found in the urinary section at most stores and pharmacies help with sepsis but should not be taken if you are anemic or G6PD deficient. If you have high levels of glyphosate or glufonisate you can be G6PD deficient.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770994/

https://www.medicinenet.com/methylene_blue-oral/article.htm

This site has a list of the various forms of Methylene Blue so you will know what to look for on the package.

https://www.goodrx.com/methylene-blue/what-is

Atropine also helps with sepsis and has the added benefit of detoxing glufonisate, glyphosate and orthophosphates.

https://www.ncbi.nlm.nih.gov/pubmed/18369575

https://www.ncbi.nlm.nih.gov/pubmed/7621764

https://www.ncbi.nlm.nih.gov/pubmed/8415873

Moringa is good stuff it helps with just about everything.

https://www.hindawi.com/journals/isrn/2014/906843/

Proteus Mirabilis is acquire in hospitals usually from catheters and is one of the hardest to get rid of.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4638163/

https://www.ncbi.nlm.nih.gov/pubmed/21921687

Epilobium helps with antibiotic resistant strains of infection. Known as willow herb.

https://www.degruyter.com/view/j/chem.2016.14.issue-1/chem-2016-0004/chem-2016-0004.xml

Willow herb also reduces inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/21112753

Helps restore antioxidant homeostasis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783546/

Calcium supplements cause urinary tract infection can also raise oxalates. That is why I get my calcium from stinging nettles. If you eat fruits and vegetables you should be getting enough calcium. Most bone lose is caused by either silica or magnesium deficiency. Calcium deficiency is rare.

https://www.ncbi.nlm.nih.gov/pubmed/2204174

https://draxe.com/stinging-nettle/

https://www.organicfacts.net/health-benefits/herbs-and-spices/stinging-nettle.html

Joe Pye also known as Gravel Root helps. It is a calcium channel blocker also though and has an alkaloid that can build up in the body so should not be used in high doses or for extended periods of time.

https://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-957558

There are toxins in feminine products that can cause IC. Organic or some alternative should be used. Cotton feminine products are from GMO cotton which contains BT Toxin which can cause many problems. This was not mentioned in the article.

https://www.thehealthyhomeeconomist.com/nontoxic-alternatives-to-tampons-and-sanitary-napkins/

I am not big on pharmaceuticals because they treat the symptoms not the cause but many of my friends have said Tempol has helped them. Please research first if you decide to try this.

https://www.karger.com/Article/FullText/430183

If you read about glyphosate you will see how it could cause IC. Glufonisate is Bayers version of glyphosate and causes the same health problems. If you read my GMO post you will see that our food is heavily contaminated.

https://people.csail.mit.edu/seneff/SamselSeneffGlyphosateIV.pdf

I seen many take metformin. They would do really good at first then get much worse so I don’t trust it. It also causes vitamin B12 deficiencies which can lead to permanent nerve damage.

http://www.diabetesincontrol.com/metformin-induced-vitamin-b12-deficiency-presenting-as-a-peripheral-neuropathy/

Things that can cause frequent urination at night.

https://www.healthline.com/health/overactive-bladder/overactive-bladder-night#causes

https://www.wikihow.com/Stop-Late-Night-Bathroom-Trips

http://www.homeremediesforall.com/natural-remedies/frequent-urination-at-night.html

Many have had good results with lactoferrin. It helps the good bacteria get reestablished. It is not mentioned in the article but it chelates the bad iron from the body and builds up heme by giving the body good iron.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614382/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837981/

Lactoferrin has been found to break up biofilms and so has serrapeptase. Serrapeptase also breaks up scar tissue but can cause problems if taken in very high doses. It helped me a lot. Biofilms make many infections impervious to the immune system and even drugs.

https://www.hindawi.com/journals/ab/2014/543974/

http://www.tiredoflyme.com/biofilm.html

Biofilm busters.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648868/

https://www.selfhacked.com/blog/44-science-backed-ways-to-inhibit-biofilms-naturally-with-references/

This article mentions nattokinase. I did not use it because it has estrogen like effects. I figured boobs would not look good on a man.

https://blog.designsforhealth.com/biofilms-and-resistance

I got candida from antibiotics. I fell for the alkazing myth and things got much worse for me so I started doing the opposite. Lo and behold it started going away. Candida likes and alkaline environment and will actually switch from commensal (friendly) to a pathogen if the alkalinity of digestive system or bladder gets too alkaline. Our bladder and digestive tract is supposed to be acidic. We have bacteria that keeps our bladder and digestive system at the correct PH. If we are deficient in those bacteria then our digestive system and bladder can become alkaline promoting infection of many types of pathogens especially candida.

https://www.candidaplan.com/10-candida-myths-2/

Japanese Honeysuckle helped me a lot. It is the one with the white and yellow flowers. Most other types of honey suckle are poisonous. It reduces inflammation and has pain killing abilities. It made me sleepy but the baby does of baby benadryl does that to me.

https://www.ncbi.nlm.nih.gov/pubmed/27534446

Golden rod helped me. It kills pathogens reduces pain and inflammation. I herxed the first time I used it. This is the European Golden Rod but Solidago Canadensis found in the US has just about the same properties.

https://www.ncbi.nlm.nih.gov/pubmed/27249953

I hate to say this because I love salt but salt makes things worse. But studies have shown that if you use see salt you do not crave as much salt because it has more nutrients needed by the body.

https://www.ncbi.nlm.nih.gov/pubmed/6191542

Flavocoxid is a combination of ingredients. I took these ingredients separately on my own and they healed me so fast that all heck broke loose from my nerves and muscles waking up when my blood flow improved and my nerves woke up. I got bad muscle spasms and my nerves felt hot. After about three days though I felt great. And each day after I could actually feel it healing me. I did not know about this supplement that already had them in it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765324/

Even newer stuff.

If we do not get enough cholesterol we cannot heal. Cholesterol is needed by the cells to protect us from inflammation, infections, our heart , brain, liver and kidneys cannot function without it. Statins destroy brain cells in a way they cannot repair it almost petrifies them because they deprive them of cholesterol. Read my post on how high oxLDL is a symptom not a cause.

http://www.greenmedinfo.com/blog/underreported-dangers-low-cholesterol

https://chriskresser.com/why-you-should-eat-more-not-less-cholesterol/

Sculletaria heals things all through the body. I used American Sculletaria which is much more powerful. I would not recommend that because it healed me too quickly and when things started waking from the nerves healing and improved blood flow all heck broke loose for a few days.

https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-015-0682-8

I am putting this here for a note, I have not gotten to research it. Pathogens in the bladder induce Indoleamine 2.3-Dioxygenase in the bladder which inhibits immune response.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415894/

Antiphospholipid Syndrome can present in the renal system. This can be cause by tick born illness, vaccine injury or farm chimicals in food especially glyphosate.

Thuja helps with cystitis but there are better source then white cedar. Mugwort and wormwood are much better alternative sources of Thuja.

https://www.ncbi.nlm.nih.gov/pubmed/25818694

Excess lipid peroxidation can cause many problems, high oxLDL, high ammonia , inflammtion, the list goes on and on. These naturals inhibit lipid peroxidation.

https://www.ncbi.nlm.nih.gov/pubmed/17726737

Inhibiting 5-Lo reduces inflammation. Mediterranean Sage an invasive weed in the western states of the United States ihibits 5-Lo.

https://link.springer.com/article/10.1007/s000110050730

Oxeye Daisy kills pain and reduces inflammation. I seen no studies on it being a sedative but when I drink it I end up going to sleep every time.

https://www.herbal-supplement-resource.com/daisy-herb-benefits.html

Ebselen is one of the few drugs I would take it reverses sepsis, reduces oxidative stress, heals the brain and bladder and does many other things. Unfortunately they will only prescribe it to people with psychosis.

https://www.sciencedirect.com/science/article/pii/S0014579396012379

A list of foods and their oxalate levels. I noticed a few of the low oxalate were GMO which is worse if you read my page on that.

https://healinghistamine.com/low-oxalate-low-histamine-diet-the-missing-link/

I put five drops of tea tree oil in about 10 ounces of jojoba oil and it really reduced the burning and rashes on my skin. Tea tree reduces histamines and substance P. Do not consume it though.

https://www.ncbi.nlm.nih.gov/pubmed/12452873

Proteolytic enzymes helped me a lot. They have many benefits like reducing inflammation, aiding with digestion, kill parasites. They made it so I could eat.

https://draxe.com/proteolytic-enzymes/

St. Johnswort reduces pain inflammation and has antioxidant properties. I seen studies that claimed it was toxic to the liver. Those studies where vague as to methodology and lacking data. Most studies I have read on St Johnswort showed it to be non toxic and does the opposite it actually reduce inflammation in the liver.

https://www.ncbi.nlm.nih.gov/pubmed/25851311

https://www.karger.com/Article/Pdf/21265

https://draxe.com/st-johns-wort-uses/

This is a good article on reducing inflammation with food and why they work.

http://www.itmonline.org/arts/lox.htm

Antibiotics, GMOs and herbicides kill our gut bacteria. Certain gut bacteria use tryptophan to modulate our immune system. We become prone to infection if we are lacking those bacteria, especially candida infection. Consuming foods high in tryptophan helps restore them and our immune function. Our adaptive immunity comes from our gut bacteria. When we are low or deficient in certain ones we can have either an over active immune response or non at all. This also protects us from inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/29341448

https://www.sciencedirect.com/science/article/pii/S1074761313003312

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292609/

Tryptophan was found to be low in those with MCAD.

https://www.prohealth.com/library/study-shows-that-mast-cell-activation-a-disorder-common-in-lyme-disease-causes-depression-5478

Foods high in tryptophan to feed the gut bacteria. Many of the things mentioned are dried using glyphosate and glufonisate especially beans and grains so make sure you eat organic. Those destroy our good gut bacteria making us prone to many pathogens.

https://www.myfooddata.com/articles/high-tryptophan-foods.php

https://nootriment.com/tryptophan-foods/

The metabolic issues I had made it impossible for me to eat meat because of the high phenylalanine content, potatoes and other things high in phenylalanine were out also. I had to eat a vegetarian diet for a very long time until I corrected my metabolic issues. If you have sulfation issues or upregulated BH4 or CBS pathways your will develop very high ammonia levels because sulfite levels rise very high and causes you body to be unable to recycle phenylalanine. So as it is used the biproducts produced build up in the blood stream and ammonia is one of them.

https://www.veganmotivation.com/tryptophan-foods-boost-serotonin/

Though NO can cause damage in the body it is needed to maintain health. So we do not want to reduce it too low. It will cause many negative health issues if we do. That is why many develop high blood pressure when under oxidative stress because it depletes NO. Homeostasis should always be the goal.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906415/

Olive leaves are very good for fighting infection but if you have a high metabolism they are not good for you. They speed up the metabolism. Olive oil has many benefits. It activates the Nrf2/keap1 pathway which is a key part of our antioxidant system that protects our cells. If you have pyrole issues you will have gall bladder pain and/or indigestion when you consume oils. Supporting sulfation will helps with pyrole issues. Also reducing histamines and inflammation help correct issues with pyroles.

http://www.phytochemicals.info/plants/olive.php

Rehmania raises blood pressure. I have cardititis and this help get my blood pressure up which made me feel much better. I did not take it everyday though because homeostasis should always be the goal. It also reduces oxidative stress.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331951/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5900793/

Before I got my gut straightened out my brain was a mess. We need butyric acid but our limited diets prevent us from eating the foods that contain it like milk products and the plants that contain the fiber many of us cannot eat because of sulfation issues which many plants that contain inulin which our gut bacteria produce butyric acid from are high in sulfur. Onions are one example of that and I was so lactose intolerant that milk products were definitely out. The solution for me was to make ghee. All the lactose is removed but the butyric acid remains. It made a world of difference in my health I had more energy and could think so much clearer. Since I have my gut healed and my metabolic issues straightened out I can eat pretty much anything.

https://wholehealthsource.blogspot.com/2009/12/butyric-acid-ancient-controller-of.html?spref=fb

If you have chemical sensitivities or sensitivity to odors then you have glucuronidation issues. Calcium-D-Glucarate helps address that. I had problems with this bad. Even the candle section in stores would make me ill and even affect my bladder.

https://www.diagnose-me.com/treatment/calcium-D-glucarate.php

https://blog.bulletproof.com/calcium-d-glucarate/

If you have metabolic issues and try to change to a healthier diet it could backfire. We must take the nutrients that support those pathways. If not there will be a lot of food we will not be able to eat.

https://www.anniehelpsyou.com/blog/item/2-are-phenol-oxalate-sensitivities-causing-your-health-problems

P53 role in cystitis.

http://europepmc.org/articles/PMC1939966

This is only an abstract but it list illnesses caused by high TH17 levels. Vaccine adjuvants, many farm chemicals and heavy medals can cause high TH17 levels. Tick born illness can also if the endotoxin levels get high enough. If you notice you will see many commonalities with IC.

https://www.annualreviews.org/doi/full/10.1146/annurev-pathol-011110-130318#_i21

Antibiotics and farm chemicals kill our good gut bacteria that protects us from infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911494/

We have commensal bacteria that are related to pathogenic. When they are killed by antibiotics or farm chemicals we lose that protection and become prone to illness from the pathogenic ones. Ever notice how many will eat the same contaminated food but only some of them would get ill. They liked the commensal relatives of the pathogenic bacteria so were not protected. Unfortunately the only probiotic I found that contains the commensal E Coli strain is VSL#3 and it is very expensive.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862908/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869251/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083503/

These studies show the importance of our gut bacteria to the health of our organs throughout the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624329/

https://www.sciencedirect.com/science/article/pii/S2212877816300564

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351195/

https://www.ncbi.nlm.nih.gov/pubmed/21778036

Modern day chemicals in our food supply and antibiotics can ruin our ability to produce FUT2 enzymes. These modulate our immune system and keep our gut bacteria balanced and happy. If we are not producing FUT2 enzymes then we cannot fight infection and our gut bacteria will get out of balance and we will even become deficient in some bacteria. Many will take probiotics with not results for this very reason.

https://www.nature.com/articles/ismej201464

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516493/

If we are FUT2 deficient it indicates that we are lacking Bacteroides Thetaiotaomicron which is supposed to be one of the most numerous of the gut bacteria. If we are lacking this bacteria we will have trouble eating certain carbs and cannot break down many types of fiber.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840232/

They claim it is a genetic issues but other gut bacteria regulate FUT2 secretion

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800993/

This is a list of gut microbiotia and their effects on the digestive system and the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873327/

What complicates things is that the medical community cannot identify the difference between commensal and pathogenic. Often times they give antibiotics that kill bacteria we need. When we get an infection from a bacteria that is usually commensal it means something is out of balance in the body. Instead of looking for the problem they kill the commensal bacteria that we need.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988121/

http://mbio.asm.org/content/5/6/e01817-14.short

Getting chlamydia shows there is a deficiency in Lactobacilli which balances the ph of our bladders and digestive system. Most pathogens cannot survive in an acid ph which is what the bladder and digestive system are supposed to be.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0107758

So an imbalance in our bacteria causes us to become prone to urinary tract infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684288/

Our bacteria even protects us from respiratory infection.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370528/

If you notice these are receptors involved in IC. This study shows that our good bacteria regulate our gene expression. It is the bacteria we inherit from our parents that determines what illnesses we will be prone to. Not only that but the foods we eat determines which genes they turn off and on.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339702/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219689/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433529/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866888/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909826/

Here is where it can get confusing. Some strains of lactobacillus are pathogenic. We have to make sure the strains we take are ones that reduce inflammation and histamines. We need inflammation and histamines for the body to heal and repair but when there is and imbalance in our gut bacteria the strains that cause them become more numerous and histamine and inflammation levels become too high.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565189/

Germ theory has been proven wrong repeatedly yet they base their research on vaccinations on it. Our gut bacteria modulate and train our immune system. So vaccinating overrides our ability to develop immunity which means the only thing it would do is confuse the body.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892783/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352444/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902499/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722804/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221693/

Our gut bacteria even regulate our biological clock.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5780501/

Our gut bacteria determine if we will be obese or not.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127273/

Our gut bacteria regulate our mood and emotions.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987167/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987016/

An imbalance in our bacteria in our lungs can result in lung disease.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586181/

We even have a gut bone axis and our bone is effected by our gut bacteria.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742533/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235701/

Our gut bacteria even regulate our cholesterol levels.

https://www.ncbi.nlm.nih.gov/pubmed/29209439

This is why it is very important to get polyphenols, oligosaccharides and polysaccharides in our diets. It feeds our beneficial bacteria which promotes better health. There are myths about the sugars in foods like fruits and vegetables feeding candida when it becomes pathogenic but the opposite is true. Much of the false information out there drives me to believe that the pharmaceutical companies put it out there to keep people on a hamster wheel of poor health so they will have a steady customer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493053/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000740/

https://www.cell.com/trends/microbiology/fulltext/S0966-842X(16)30143-3

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4961256/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429330/

Not only do we need to feed the good gut bacteria but our diets to manipulate our gut bacteria needs to be unique to each of us. A diverse diet gives us a diverse microbiome which protects our health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801817/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918027/

The myth I see that is the most damaging is people being told to avoid all fats. They are a necessary nutrient for good health.

https://www.ncbi.nlm.nih.gov/pubmed/28482838

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650612/

Another myth is to avoid carbohydrates. It is a good way to develop autoimmune disease. We need a variety in our diet.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857604/

I find it strange that almost all science surrounding modern medicine is being proven wrong by science that is thousands of years old.

We have commensal virome in our gut. What happens when antibiotics or farm chemicals kill them. How do we replace them and restore out health?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656937/

Our gut virome also regulate our immune system.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923440/

Our gut bacteria even secret non toxic antibiotics that do not kill the good bacteria like man made antibiotics do.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586196/

This is a study on female urinary biome and health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161260/

Male urinary biome and health.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990618/

If you are prone to E Coli you may be lacking the phage or virus that protects us from it.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967307/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900583/

https://www.ncbi.nlm.nih.gov/pubmed/21412185

If you get tick born illness, yep lacking gut phages.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097911/

Peroxisomes secreted by our gut bacteria protect us from excess reactive oxygen species generated during oxidative stress.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0117851

This is a list of microbiota and their functions.

https://onlinelibrary.wiley.com/doi/full/10.1111/j.1574-695X.2005.00026.x

https://mentalhealthdaily.com/2016/03/01/10-best-probiotics-for-depression-anxiety-gut-brain-axis-modification

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992746/

This is a symposium on microbiome.

https://www.tandfonline.com/toc/zmeh20/current

When I ate anything including fruit I got very ill, probiotic yeast help a lot with that. It would feel like a brick was setting in my stomach after I ate. This helped me a lot. Also if I ate carbohydrates I would feel ill this corrected that also.

https://www.healio.com/gastroenterology/irritable-bowel-syndrome/news/online/{bb454dd3-01bf-4720-a01e-912c62d09062}/probiotic-yeast-improves-abdominal-pain-bloating-in-ibs-c-patients

If you have problems eating dairy these are the strains needed. I had very bad dairy issues. Some of the strains that break down dairy also break down carbohydrates.

https://www.sciencedirect.com/science/article/pii/S0023643812000503

https://www.sciencedirect.com/science/article/pii/S0963996912000890

https://pubs.acs.org/doi/abs/10.1021/acs.jafc.6b00714?journalCode=jahttp

These are the strains needed for urinary and bladder issues.

https://www.hindawi.com/journals/au/2009/680363/

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1151418

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684288/

If your microbiome imbalance persist it may be from your sexual partner.

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-016-0161-6

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225992/

https://academic.oup.com/aje/article/156/12/1133/151795

These articles mention the probiotics to avoid if you have high histamines. The second link mentions the ones that reduce histamines.

http://www.low-histamine.com/tag/probiotics/

https://wholenewmom.com/health-concerns/low-histamine-probiotics/

P53 levels are found to be low in most IC cases. I did not pursue increasing this because most cancers have high levles of P53. I think it would be better to find out what is inhibiting it and correct that rather then trying to increase it.

http://europepmc.org/articles/PMC1939966

It should be clear to most now that the genetic theory of inherited imperfections causing illness is not accurate.

Genetically modified foods destroy our health glyphosate and glufosinate add to the toxicity.

Monsanto now owned by Bayer and has dropped the name but when the company was Monsanto they colluded with the government to hide the harm their products are doing.

https://www.baumhedlundlaw.com/toxic-tort-law/monsanto-roundup-lawsuit/monsanto-secret-documents/

https://foodbabe.com/emails-epa-monsanto-now-revealed-contents-sickening/

https://content.sierraclub.org/grassrootsnetwork/team-news/2015/09/monsanto-s-sealed-documents-reveal-truth-behind-roundup-s-toxicological-dangers

https://usrtk.org/wp-content/uploads/2018/04/FDA-Richard-Thompson-wheat-crackers-email.pdf

https://ehjournal.biomedcentral.com/articles/10.1186/s12940-016-0117-0

What it does to the enviroment.

http://www.sierraclub.ca/national/programs/health-environment/pesticides/glyphosate-fact-sheet.shtml

Symptoms of high glyphsate or glufonisate levels.

http://www.national-toxic-encephalopathy-foundation.org/roundup.pdf

What it may be doing to your health.

https://www.westonaprice.org/health-topics/environmental-toxins/roundup-the-nontoxic-chemical-that-may-be-destroying-our-health/

Possible risk involved with eating GMO foods.

http://responsibletechnology.org/gmo-education/section5/

Studies have shown that most of our food contains high levels of these toxins.

https://www.jillcarnahan.com/2015/11/22/glyphosate-toxicity/

https://www.omicsonline.org/open-access/survey-of-glyphosate-residues-in-honey-corn-and-soy-products-2161-0525.1000249.php?aid=36354

https://www.goodhousekeeping.com/health/diet-nutrition/a20706601/how-much-toxic-roundup-are-you-eating/

https://www.ecowatch.com/why-is-glyphosate-sprayed-on-crops-right-before-harvest-1882187755.html

https://anhinternational.org/2015/07/01/crops-most-likely-contaminated-by-glyphosate/

https://www.momsacrossamerica.com/widespread_glyphosate_contamination

https://water.usgs.gov/nawqa/pnsp/usage/maps/show_map.php?year=2011&map=GLYPHOSATE&hilo=L&disp=Glyphosate

https://www.westonaprice.org/health-topics/abcs-of-nutrition/folic-acid-glyphosate/

https://freetheanimal.com/2015/06/enrichment-theory-everything.html

https://toxics.usgs.gov/highlights/2014-04-23-glyphosate_2014.html

Many studies show we have high levels of glyphosate in us.

https://www.omicsonline.org/open-access/detection-of-glyphosate-residues-in-animals-and-humans-2161-0525.1000210.php?aid=23853

So now you can see the importance of testing for glyphosate or glufonisate.

https://www.greatplainslaboratory.com/articles-1/2017/1/23/the-importance-of-testing-for-glyphosate-the-worlds-most-widely-used-herbicide

Take all the evidence below and compare it to the rise in many health issues and you will see what is causing many of them.

http://www.i-sis.org.uk/Deterioration_of_Public_Health.php

Neurological deaths increased as glufonisate and glyphosate usage increased.

There is obvious conditional bias in biotechs research.

http://www.endsciencecensorship.org/en/page/retraction-double-standards#.VnQrUlAo5Ag

Going by Monsantos standards all of Monsanto’s studies are invalid.

http://www.endsciencecensorship.org/en/page/retraction-double-standards

GMO are regualed as a pesticide by the FDA.

http://www.epa.gov/pesticides

Studies showing the dangers of GMOs get ignored.

http://www.sciencedirect.com/science/article/pii/S0890623811000566

The effects of the toxins are lethal.

http://onlinelibrary.wiley.com/doi/10.1002/jat.2712/abstract

Studies showing the dangers of any of Monsanto’s products are ignored.

http://www.ncbi.nlm.nih.gov/pubmed/23756170

http://www.ncbi.nlm.nih.gov/pubmed/21338670

GMO producers try to pass off privately funded studies as independent studies.

http://www.foodandwaterwatch.org/insight/pro-gmo-database-monsanto-most-common-funder-gmo-research

Why are the GMO producers working so hard to keep everything a secret?

http://www.scientificamerican.com/article/do-seed-companies-control-gm-crop-research/

There has been proven conflicts of interest in the research on the safety of GMOs.

http://www.sciencedirect.com/science/article/pii/S0306919210001302

GMO increase herbicide and pesticide use.

http://www.enveurope.com/content/24/1/24/abstract

http://static.ewg.org/agmag/pdfs/pesticide_use_on_genetically_engineered_crops.pdf

GMOs raise production cost.

http://modernfarmer.com/2013/12/post-gmo-economy/

GMOs cost farmers more and create super bugs.

http://www.news.cornell.edu/stories/2006/07/bt-cotton-china-fails-reap-profit-after-seven-years

One of biotechs biggest advocates have had many studies retracted and some involved GMO research

http://retractionwatch.com/?s=pamela+ronald&submit=Search

The positive hype surrounding GMOs is based on studies that have been retracted

http://www.gmwatch.org/news/archive/2013/15198-gmo-hype-based-on-retracted-science

There was a hidden viral gene found in GMOs

http://www.i-sis.org.uk/Hazardous_Virus_Gene_Discovered_in_GM_Crops.php

They are not sure what the affects on humans or plants will be.

http://www.independentsciencenews.org/#article/1421

They know there is the risk of horizontal gene transfer. So what if the genes transfer to those consuming the GMO food. Now their bodies will become there own enemy.

I believe it is one of the contributing factors behind autoimmune disease.

http://www.ncbi.nlm.nih.gov/pubmed/18801324

They are trying to fix a problem that doesn’t exist. There has always been food that sits and rots. The real problem is food wastage.

https://www.nrdc.org/food/files/wasted-food-ip.pdf

http://www.usda.gov/oce/foodwaste/

http://www.npr.org/sections/thesalt/2014/02/27/283071610/u-s-lets-141-trillion-calories-of-food-go-to-waste-each-year

http://www.bloomberg.com/news/articles/2013-02-08/u-s-corn-surplus-estimate-raised-5-on-slowing-global-demand

http://www.agri-pulse.com/U.S.-corn-surplus-seen-at-1.63-billion-bushels-down-9-vs-December-estimate-01102014.asp

Now the proven harm GMOs are doing.

Glyphosate used to dry beans and grains and used to spray on crops that are RoundUp ready causes many health issues. Bayer has their version called Glufonisate and it causes the same problems.

Destroys bone marrow

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809416/

https://www.hindawi.com/journals/jt/2009/308985/

Can cause menningitis.

https://www.ncbi.nlm.nih.gov/pubmed/21370950

Can cause erectile dysfunction

https://www.sciencedirect.com/science/article/pii/S2305050015000305

Can make a man sterile

https://www.ncbi.nlm.nih.gov/pubmed/22120950

https://www.sciencedirect.com/science/article/pii/S0891584913003262

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1638308/

How do we know this didn’t cross pollinate with other corn?

https://www.indybay.org/newsitems/2010/06/11/18650455.php

Can cause heart issues.

https://link.springer.com/article/10.1007/s12012-014-9299-2

Can cause high dopamine levels.

https://www.sciencedirect.com/science/article/pii/S0300483X13001637

Can cause convulsions.

https://www.sciencedirect.com/science/article/abs/pii/S0304394001017657

Causes excess oxidative stress and makes aluminum more toxic.

https://www.sciencedirect.com/science/article/abs/pii/S030439400001363X

https://onlinelibrary.wiley.com/doi/full/10.1002/(SICI)1098-2280(1998)32%3A1<39%3A%3AAID-EM5>3.0.CO%3B2-6

https://onlinelibrary.wiley.com/doi/full/10.1002/(SICI)1098-2280(1998)32%3A1<39%3A%3AAID-EM5>3.0.CO%3B2-6

Causes fatty liver

https://ehjournal.biomedcentral.com/articles/10.1186/s12940-015-0056-1

GMO cause celiac disease.

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200002&lng=en&nrm=iso&tlng=en

http://earthopensource.org/gmomythsandtruths/sample-page/3-health-hazards-gm-foods/3-8-myth-gm-bt-insecticidal-crops-harm-insects-harmless-animals-people/

https://www.drthrasher.org/bt-toxins

Causes cell division disfunction.

https://www.ncbi.nlm.nih.gov/pubmed/11896679

Causes bladder cancer.

https://www.ncbi.nlm.nih.gov/pubmed/26411407

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018465/

Exposure to farm chemicals in children’s food raises the risk of cancer.

https://www.beyondpesticides.org/resources/pesticide-induced-diseases-database/cancer

Glyphosate depletes nutrients from the body. I will provide the supporting research later.

http://www.digitalnaturopath.com/cond/C371961.html

BT Toxin is cytotoxic to our cells and adding glyphosate or glufonisate makes things worse.

https://onlinelibrary.wiley.com/doi/abs/10.1002/jat.2712#.VnQ4wOfiKlA.facebook

https://www.ncbi.nlm.nih.gov/pubmed/25268978

BT Toxin cause an immune respronse. Which causes gut inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/10353588

All environmental chemicals have effects on our guts especially antibiotics which glyphosate was originally patented as.

https://www.nature.com/articles/npjbiofilms20163

https://glyphosatestudy.org/wp-content/uploads/2018/05/MICROBIOME-GLY-PILOT-IN-PRESS-8-5-1.pdf

https://www.sciencedirect.com/science/article/pii/0014579383808886

This can lead to many metabolic disorders.

https://www.nature.com/articles/nature12506

https://www.nature.com/articles/srep08731

Can also lead to mental disorders.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228144/

https://www.scirp.org/journal/PaperInformation.aspx?PaperID=53106

https://www.sciencedirect.com/science/article/pii/S088915911630040X

https://www.sciencedirect.com/science/article/pii/S0161813X17301183

https://www.ncbi.nlm.nih.gov/pubmed/24636977

Causes fatty liver.

https://www.nature.com/articles/srep39328

Glyphosate is toxic to the liver.

https://www.omicsonline.org/open-access/studies-of-acute-and-chronic-toxicity-of-commercial-herbicides-withglyphosate-against-danio-rerio-2161-0525-1000340.php?aid=67212

https://ehjournal.biomedcentral.com/articles/10.1186/s12940-015-0056-1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987375/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742203/

https://www.degruyter.com/view/j/acve.2016.66.issue-2/acve-2016-0018/acve-2016-0018.xml

https://ehjournal.biomedcentral.com/articles/10.1186/s12940-015-0056-1

GMOs cause symptoms similar to food poisoning.

https://kclpure.kcl.ac.uk/portal/en/publications/an-integrated-multiomics-analysis-of-the-nk603-rounduptolerant-gm-maize-reveals-metabolism-disturbances-caused-by-the-transformation-process(dc5738b1-0357-4a54-b42b-25b3a6d85f14)/export.html

http://www.biochemj.org/content/328/3/847

Glyphosate impedes our cells ability to repair.

https://academic.oup.com/toxsci/article/82/2/436/1656977

https://www.ncbi.nlm.nih.gov/pubmed/11896679

My alter the DNA of children.

http://www.i-sis.org.uk/Sperm_Mediated_Inheritance_of_Acquired_Character.php

Glyphosate can cause blood disorders.

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842010000400005

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600513/

The health effects of BT Toxins have not been researched properly.

https://enveurope.springeropen.com/articles/10.1186/s12302-016-0099-0

This covers all the illnesses glyphosate and toxins like it can cause.

https://glyphosatestudy.org/wp-content/uploads/2018/05/COMMENTARY-GLY-PILOT-IN-PRESS-Manuscript-8-5-1.pdf

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1679775/

https://sciforschenonline.org/journals/neurology/article-data/JNNB-3-140/JNNB-3-140.pdf

http://www.mdpi.com/1099-4300/15/4/1416

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945755/

http://surgicalneurologyint.com/surgicalint-articles/glyphosate-pathways-to-modern-diseases-iii-manganese-neurological-diseases-and-associated-pathologies/

https://www.researchgate.net/publication/283490944_Glyphosate_pathways_to_modern_diseases_IV_cancer_and_related_pathologies

https://jamanetwork.com/journals/jamaoncology/fullarticle/2294966

https://www.researchgate.net/publication/305318376_Glyphosate_pathways_to_modern_diseases_V_Amino_acid_analogue_of_glycine_in_diverse_proteins

https://www3.nd.edu/~aseriann/Glyphosate_2.pdf

https://drjess.com/recovery-methods-brain-aluminum-glyphosate-exposure/

The body mistakes glyphosate for glycine.

https://www.ommegaonline.org/article-details/Does-Glyphosate-Acting-as-a-Glycine-Analogue-Contribute-To-ALS/1173

Glyphosate combines with heavy metals to become more toxic.

https://www.sciencedirect.com/science/article/pii/S221475001730149X

BT Toxin is toxic to our bodies and now it grows inside the GMO food.

http://ddata.over-blog.com/xxxyyy/3/19/57/29/Bacillus-thuringiensis–danger.pdf

Plants regulate our gene expressions can you imagine what GMOs are doing.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5374554/

Glyphosate causes neurodegeneration.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288661/

Even in small amounts it is toxic.

https://www.ncbi.nlm.nih.gov/pubmed/23044091/

Is the cause in the rise of gout.

http://www.amsi.ge/jbpc/21717/04SE17A.pdf

Crosses the placenta.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257596/

Glyphosate is an endocrine disruptor.

https://www.sciencedirect.com/science/article/pii/S0278691516304896

Now you know the real reason wheat is toxic.

http://realfarmacy.com/reason-toxic-wheat/

How to detox glyphosate

https://myersdetox.com/166-glyphosate-herbicide-and-how-to-detox-it-with-dr-stephanie-seneff/

Glyphosate causes miscarriages and preterm births.

http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=83267

http://www.reduas.com.ar/wp-content/uploads/2011/04/primer-informe.pdf

https://ehjournal.biomedcentral.com/articles/10.1186/s12940-018-0367-0

Vaccinations spread and cause disease.

Those who believe in God I have put scriptures at the bottom to support our stance.

I left the studies that they claimed were proven wrong because they were not proven wrong they changed the definition of the many mental conditions caused by vaccinations also they put up smoke screens by saying vaccinations trigger autism they don’t cause it. That is like saying bullets do not kill a person it is their inherent weakness to the bullet that causes death or injury. They also blame the vaccine injuries on polymorphisms and comorbities and again saying vaccinations were a trigger but not the cause. Who doesn’t have a gene mutation or an existing infection​ The sad part is vaccine injury can take years to fully manifest itself so most do not even know they have been injured by the vaccination. When they develop chronic fatigue syndrome, arthritis, fibromyalgia, autoimmune disease, or mental problems they are told the cause is unknown. The pharmaceutical companies profit from the illnesses along with the medical organizations because they have created a steady customer. All this is at the expense of the tax payer who has to support those injured and disabled by vaccinations. Many of those in positions of authority at the FDA, USDA, CDC, and IDSA used to work for the pharmaceutical industry. Also the former presidential administration and the president place many from biotech and the pharmaceutical industry in positions of power. Most biotech firms are owned by pharmaceutical companies. It is clear our government is run by the pharmaceutical industry. There is a lot of profit in vaccination for the pharmaceutical industry and doctors. Once injured a steady customer has been created.

I am going to cover symptoms of vaccine injury so that people will know what to look for and report it. The government says as little as 10% of adverse vaccine events get reported. Many medical professions claim it is much lower. So that means most adverse reactions to vaccinations are not being reported. Most doctors will not report it and will try to cover up the vaccine injury or death. The weight of reporting it will go to the person injured or the parents of the child injured. Information on reporting vaccine injury.

First symptoms of vaccine injury. High Fever Skin, Rash High Pitched screaming or frequent crying. Excessive sleeping or or in ability to sleep. Convulsions or seizures. Loss of muscle control. Nerve problems can occur throughout the body. Physical or Mental regression. More serious symptoms One side of face, or eye or lip may droop. Sudden behavior change. Frequent rashes. autoimmune disease allergies or food intolerance. Gut issues Disproportionate growth of face. Will not make eye contact. Multiple Sclerosis, Chronic Fatigue Syndrome, Muscoskeletal Disorders, Gastro intestinal issues.

http://www.nvic.org/ http://www.uscfc.uscourts.gov/sites/default/files/20140513%20GUIDELINES%20FOR%20PRACTICE%20Final%20OSM.pdf https://vaers.hhs.gov/index

https://vaccineimpact.com/resources/

https://wellnessandequality.com/2016/06/20/how-much-money-do-pediatricians-really-make-from-vaccines/

Vaccinations enhance susceptibility to infectious disease.

https://www.ncbi.nlm.nih.gov/pubmed/31826992

https://www.ncbi.nlm.nih.gov/pubmed/19022319

https://www.focusforhealth.org/worse-than-nothing

https://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.1002198&fbclid=IwAR0pHa-PWUG30Mx9hZAynDU2PdszY8VfQE96ItamQRKMSHxFaD6LlGY8Dqo

https://www.frontiersin.org/articles/10.3389/fmicb.2018.02991/full?fbclid=IwAR3-wn8YfkeC0VUXuWdPQXc80xxw71tvtP0EQEMgTgr3rm1OmHwvf4hLWto

https://www.news-medical.net/news/20200312/Could-rushing-a-coronavirus-vaccine-cause-more-harm.aspx

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288334

Their greed has blinded them so badly they will force vaccinations on you while you are sedated or asleep. What else are they doing while you are sedated or asleep?

https://www.naturalnewsblogs.com/vaccines-forced-unconscious-patients-protect/

Vaccine adjuvants are designed to cause inflammation, almost all of them are known carcinogens. They can stay in the body for years the unproven theory is that the inflammation will stimulate an immune response. That inflammation is also found to cause autism.

https://www.ncbi.nlm.nih.gov/pubmed/15546155

https://www.ncbi.nlm.nih.gov/pubmed/16401547

https://www.ncbi.nlm.nih.gov/pubmed/23557271

https://www.ncbi.nlm.nih.gov/pubmed/24238833

This study was designed to see why infant mortality was higher in some areas then others. The fact that they did this study shows they know vaccinations kill. This study also proves it is proper diet, sanitary practices and access to clean water that lowers infant mortality not vaccinations.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170075/

http://www.nvic.org/pdfs/infant-mortality-study.aspx

http://www.jpands.org/vol21no2/miller.pdf http://vaccines.news/2015-10-18-polio-vaccine-kills-boy-after-infecting-him-with-the-same-deadly-disease-its-supposed-to-prevent.html

How endotoxins are measured in vaccinations.

http://www.ncbi.nlm.nih.gov/pubmed/21337100

https://www.ncbi.nlm.nih.gov/pubmed/21093496

Vaccinations spread disease.

http://m.cid.oxfordjournals.org/content/early/2012/03/13/cid.cis287.short

http://www.ncbi.nlm.nih.gov/pubmed/21513761

The flu shot makes the flu more severe.

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0086555

The flu shot is ineffective the more you get it the less effective it is.

https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2016.21.7.30139

http://www.pnas.org/content/96/24/14001.full

Vaccinations cause auto immune disease.

http://www.discoverymedicine.com/Hedi-Orbach/2010/02/04/vaccines-and-autoimmune-diseases-of-the-adult/

The effects of toxins in vaccinations is well documented. Even the small amount in fluorescent bulbs is considered hazardous. http://www3.epa.gov/epawaste/hazard/wastetypes/universal/lamps/faqs.htm Msds

http://sanevax.org/thimerosal-material-safety-data-sheet-2/

http://www.ncbi.nlm.nih.gov/pubmed?cmd=retrieve&list_uids=16079072Bl

vaccinations are causing diseases to mutate in dangerous ways.

http://mobile.dudamobile.com/site/preventdisease?url=http%3A%2F%2Fpreventdisease.com%2Fnews%2F12%2F071712_Vaccines-Are-Causing-Mutations-That-May-Jeopardize-The-Health-of-Future-Generations.shtml&utm_referrer=#2795

http://www.alive.com/health/the-nanobacteria-revolution/

The HPV vaccine is one of the most dangerous.

https://www.ncbi.nlm.nih.gov/pubmed/25381482

https://www.ncbi.nlm.nih.gov/pubmed/23902317 Vaccinations kill.

http://www.nvic.org/Vaccine-Memorial.aspx

If vaccines do not harm or kill why does the government give vaccine manufacturers immunity. Why do they have a vaccine injury reporting and compensation system? Why did the government pass a bill to give vaccine manufacturers immunity from liability for the ill affects of vaccines? Why does the government have a vaccine injury compensation fund?

https://vaers.hhs.gov/index

http://www.hrsa.gov/vaccinecompensation/vaccinetable.html

http://www.medalerts.org/ http://www.nvic.org/vaccine-memorial.aspx

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170075/

These are question you should ask your doctor before you vaccinate.

http://m.naturalnews.com/news/048467_vaccine_industry_intelligent_questions_scientific_principles.html

Vaccinations have been used for eugenics. They have research using vaccinations for that purpose. Do you think things have changed. https://en.m.wikipedia.org/wiki/Buck_v._Bell This link has links to documents about US EUGENICS. https://www.uvm.edu/~lkaelber/eugenics/

Our government has no qualms about injuring us.

https://en.m.wikipedia.org/wiki/Unethical_human_experimentation_in_the_United_States

Vaccinations do not give immunity.

http://www.ncbi.nlm.nih.gov/pubmed/25270645

Strange infections, they don’t even look at vaccinations being the common tie.

http://wwwnc.cdc.gov/eid/article/21/11/14-1950_article

They start vaccinating for a disease shortly after outbreaks start

http://wwwnc.cdc.gov/eid/article/21/11/14-0780_article

http://wwwnc.cdc.gov/eid/article/21/11/14-1950_article

http://wwwnc.cdc.gov/eid/article/21/11/15-0850

Vaccinations injure and kill.

http://www.ncbi.nlm.nih.gov/pubmed/18454680

Vaccinations are contaminated with pathogens.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207559/

http://www.i-sis.org.uk/DNA_contamination_of_HPV_vaccines.php

http://www.ncbi.nlm.nih.gov/pubmed/16288015

http://www.ncbi.nlm.nih.gov/pubmed/10472327

http://www.ncbi.nlm.nih.gov/pubmed/25877010

Vaccinations contain foreign DNA and albumin which can cause autoimmune disease and could carry pathogens that cannot be detected. Just look at the ingredients in vaccinations.

http://www.merck.com/product/usa/pi_circulars/p/proquad/proquad_pi.pdf

https://catalog.coriell.org/0/Sections/Search/Sample_Detail.aspx?Ref=AG05965-D&PgId=166

http://www.atcc.org/products/all/CCL-75.aspx

http://www.merck.com/product/usa/pi_circulars/m/mmr_ii/mmr_ii_pi.pdf

http://www.ncbi.nlm.nih.gov/pubmed/24841366

http://jcm.asm.org/content/39/3/879.full?view=full&pmid=11230398

http://www.vaccine-tlc.org/human

http://vaccinationcouncil.org/2012/03/09/common-vaccine-ingredient-implicated-in-nejm-article-as-causative-in-serious-type-of-kidney-disease-by-suzanne-humphries-md/

http://www.fda.gov/BiologicsBloodVaccines/Vaccines/QuestionsaboutVaccines/ucm143521.htm

http://www.ncbi.nlm.nih.gov/news/11-24-2014-biosample-curated-list-cell-lines/?campaign=facebook-11252014

http://www.know-vaccines.org/?page_id=309

http://vaxtruth.org/2011/08/vaccine-ingredients/

http://www.americanpharmaceuticalreview.com/Featured-Articles/117498-Potential-Mycoplasma-Contaminants-Inactivation-during-Production-of-Inactivated-Egg-Based-Viral-Vaccines/

Some vaccinations contain toxins which has been shown to cause mental disorders.

http://traceamounts.com/scientific-papers-showing-linking-thimerosal-exposure-to-autism/

They contain aluminum which causes all kinds of health problems.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819810/?tool=pubmed

Reading this made me see that vaccinations set you up for autoimmune disease. There is foreign DNA in them which sets an immune response off. Now add the excitotoxins which don’t leave the body and causes a steady cytokine response. Now that your immune system is a wreck throw in a pathogen like one of the herpes virus or Lyme and now you have autoimmune disease.

https://www.ncbi.nlm.nih.gov/pubmed/23576057

https://www.ncbi.nlm.nih.gov/pubmed/22235045

https://www.ncbi.nlm.nih.gov/pubmed/25427994

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665673/ vaccine damage

https://www.ncbi.nlm.nih.gov/pubmed/23579772

https://www.ncbi.nlm.nih.gov/pubmed/25882168 Shingles vaccine causes depression.

http://m.cid.oxfordjournals.org/content/56/8/1085

https://www.ncbi.nlm.nih.gov/pubmed/11174412?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/12532044?dopt=Abstract

How about antiphospholipid syndrome for vaccine injury.

http://escholarship.org/uc/item/7ff467xp

https://www.ncbi.nlm.nih.gov/pubmed/22235053

https://www.ncbi.nlm.nih.gov/pubmed/23579772

http://escholarship.org/uc/item/7ff467xp

http://stm.sciencemag.org/content/5/200/200ra114

http://escholarship.org/uc/item/7ff467xp

http://m.rheumatology.oxfordjournals.org/content/38/7/591

http://stm.sciencemag.org/content/5/200/200ra114

http://www.cidrap.umn.edu/news-perspective/2013/08/swine-study-suggests-flu-vaccination-may-sometimes-backfire

http://www.omicsonline.com/open-access/infantile-bullous-pemphigoid-following-hepatitis-b-vaccinations-1745-7580.1000078.php?aid=35769#Full-Text

http://m.cid.oxfordjournals.org/content/54/12/1778.long

http://m.cid.oxfordjournals.org/content/early/2012/03/13/cid.cis307

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603026/

https://www.ncbi.nlm.nih.gov/pubmed/27440882

They skew the facts to scare people.

https://www.asrn.org/journal-advanced-practice-nursing/1212-do-not-believe-everything-you-read-about-flu-deaths.html

http://www.discoverymedicine.com/Hedi-Orbach/2010/02/04/vaccines-and-autoimmune-diseases-of-the-adult/

vaccine damage

https://www.ncbi.nlm.nih.gov/pubmed/23579772

https://www.ncbi.nlm.nih.gov/pubmed/25882168 Shingles

vaccine causes depression.

http://m.cid.oxfordjournals.org/content/56/8/1085

https://www.ncbi.nlm.nih.gov/pubmed/11174412?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/12532044?dopt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/22235053

https://www.ncbi.nlm.nih.gov/pubmed/12532044?d050/

https://www.ncbi.nlm.nih.gov/pubmed/23579772

https://www.ncbi.nlm.nih.gov/pubmed/25882168

https://www.ncbi.nlm.nih.gov/pubmed/21058170opt=Abstract

https://www.ncbi.nlm.nih.gov/pubmed/11174412?dopt=Abstract

http://m.cid.oxfordjournals.org/content/56/8/1085

It covers Lysomal dysregulation, macropgac myofasciitis, encephalomyelitis, lymphoma, multiple sclerosis, autoinflammatory syndrome induced by adjuvants syndrome, fribromyalgia, chronic fatigue syndrome. Many are not told they are vaccine injured they are told the cause is unknown. If you suffer from those things you may be vaccine injured.

http://journal.frontiersin.org/article/10.3389/fneur.2015.00004/full

https://www.ncbi.nlm.nih.gov/pubmed/27155490

The cause of Gulf War/Asia Syndrome

https://www.ncbi.nlm.nih.gov/pubmed/23557271

https://www.ncbi.nlm.nih.gov/pubmed/25582758

This study shows how aluminium adjuvants travel through the body to exert their toxicity.

http://www.nature.com/articles/srep31578

http://www.discoverymedicine.com/Hedi-Orbach/2010/02/04/vaccines-and-autoimmune-diseases-of-the-adult/

http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0008382

More on vaccines spreading disease.

https://www.ncbi.nlm.nih.gov/pubmed/21513761

https://www.ncbi.nlm.nih.gov/pubmed/27440882

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2603026/

http://www.medicalnewstoday.com/articles/239482.php#rate-this-article

http://m.cid.oxfordjournals.org/content/54/12/1778.long

http://www.sciencedirect.com/science/article/pii/S0264410X0800100X

Vaccines did not save us.

https://childhealthsafety.wordpress.com/graphs/

Vaccine myths debunked

https://www.sott.net/article/354522-Historical-evidence-debunks-myth-that-vaccines-eradicated-childhood-infectious-diseases

There are thousands of adverse reactions to vaccinations. Too numerous for medical professionals or customers to learn. The pharmaceutical industry does not profit from healthy people. There is more incentive in making people unhealthy, please protect your children they see them as dollar signs. Once injured or maimed by vaccinations they have created a steady customer who has to seek medical treatment for the many forms of injury vaccinations cause. The injury isn’t always obvious it can start out as a food intolerance or allergy, even something as sudden behaviour change or difficulty sleeping. http://www.vaccinationcouncil.org/2013/10/19/revelations-by-shawn-siegel/#.dpuf

It should be standard practice for vaccination history to be checked when someone especially a child has an unexplained illness or goes to the emergency room for sudden illness.

They accuse parents of being paranoid or even of seeking attention. They accuse them of abusing their child and children have even been taken from their parents because of vaccine injury. Learn to report vaccine injury because most doctors won’t and do not know how. Doctors have no training concerning vaccinations. Most don’t even know the ingredients in a vaccinations. If they offer a vaccination ask to see the vaccine insert. Do not sign a vaccine refusal paper that can be used against you. They state things in a way that it can be used to show child abuse.

Not only that but some vaccines are grown on aborted fetal tissue so by getting vaccinations we are condoning in such behavior.

http://www.lifenews.com/2017/12/09/two-companies-that-sold-aborted-baby-parts-for-planned-parenthood-forced-to-close-down/

https://www.livingwhole.org/what-you-didnt-know-about-the-aborted-baby-parts-in-your-vaccines/

Here is a list of animal and human cells found in vaccines.

https://vaxcalc.org/human

Knowing all this we are to treat our body as our temple. Vaccinations clearly violate that law. They use human fetal tissue in vaccinations. God does not condone in the murder of anyone especially not a baby. So vaccinations clearly violate God’s laws.

NASB

1 Corinthians 6:18Flee immorality. Every other sin that a man commits is outside the body, but the immoral man sins against his own body. 19Or do you not know that your body is a temple of the Holy Spirit who is in you, whom you have from God, and that you are not your own? 20For you have been bought with a price: therefore glorify God in your body.

Exodus 20:13 “You shall not murder.

The moment a child is conceived God considers it a life.

Psalms 139:For You formed my inward parts;
You wove me in my mother’s womb.
¹⁴ I will give thanks to You, for I am fearfully and wonderfully made;
Wonderful are Your works,
And my soul knows it very well.
¹⁵ My frame was not hidden from You,
When I was made in secret,
And skillfully wrought in the depths of the earth;
¹⁶ Your eyes have seen my unformed substance;
And in Your book were all written
The days that were ordained for me,
When as yet there was not one of them.

Exodus 21:²² “If men struggle with each other and strike a woman with child so that she gives birth prematurely, yet there is no injury, he shall surely be fined as the woman’s husband may demand of him, and he shall pay as the judges decide.²³ But if there is any further injury, then you shall appoint as a penalty life for life,

Whether we know God’s law or not he built a conscience in us. We have no excuse for putting children in danger and ourselves.

Romans 2:¹² For all who have sinned without the Law will also perish without the Law, and all who have sinned under the Law will be judged by the Law; ¹³ for it isnot the hearers of the Law who are just before God, but the doers of the Law will be justified. ¹⁴ For when Gentiles who do not have the Law do instinctively the things of the Law, these, not having the Law, are a law to themselves, ¹⁵ in that they show the work of the Law written in their hearts, their conscience bearing witness and their thoughts alternately accusing or else defending them,¹⁶ on the day when, according to my gospel, God will judge the secrets of men through Christ Jesus.

Those still getting vaccinated still have time to repent. Our God is a merciful and forgiving God.

Luke 5:³¹ And Jesus answered and said to them, “It is not those who are well who need a physician, but those who are sick. ³² I have not come to call the righteous but sinners to repentance.”

Isaiah 1:¹⁸ “Come now, and let us reason together,”
Says the Lord,
“Though your sins are as scarlet,
They will be as white as snow;
Though they are red like crimson,
They will be like wool.

I have done my best to warn others of the harm of vaccines and to warn them of how God would view things. So my hands are clean there is no blood on them.

Acts 20: 26 Therefore, I testify to you this day that I am innocent of the blood of all men. 27 For I did not shrink from declaring to you the whole purpose of God.

Isaiah 26:21 For behold, the Lord is about to come out from His place To punish the inhabitants of the earth for their iniquity;And the earth will reveal her bloodshed And will no longer cover her slain.

Very soon it will be too late. This is very very near.

Revelation 6:12 I looked when He broke the sixth seal, and there was a great earthquake; and the sun became black as sackcloth made of hair, and the whole moon became like blood; ¹³ and the stars of the sky fell to the earth, as a fig tree casts its unripe figs when shaken by a great wind. ¹⁴ The sky was split apart like a scroll when it is rolled up, and every mountain and island were moved out of their places. ¹⁵ Then the kings of the earth and the great men and the commanders and the rich and the strong and every slave and free man hid themselves in the caves and among the rocks of the mountains; ¹⁶ and they *said to the mountains and to the rocks, “Fall on us and hide us from the presence of Him who sits on the throne, and from the wrath of the Lamb; ¹⁷ for the great day of their wrath has come, and who is able to stand?”

Arugula another super food.

 

 

Eruca Sativa

This is not medical advice and should not be taken as such. This is for informational and educational purposes. If in doubt don’t, know a plant before you use it.

I found out about this plant by accident. I strange weed started growing in my garden. I posted it in a plant ID group on Facebook and they identified it as Arugula. I tasted it and it had a pleasant taste. Not only that I have Lyme and was having a bad day, after eating it I felt better so decided to find out more about it. I eat it in salads and on pizza but I have heard that it taste good added to dishes you would add oregano to like spaghetti.

https://www.nutrition-and-you.com/arugula.html

https://draxe.com/arugula-salad/

It would help those who have myocarditis or thrombosis it prevents blood clotting. It is probably why it made me feel better because I have Lyme carditis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277002/

It helps with neurological issues and would help with autoimmunity because it restores function of IL-10 which Lyme and HIV inhibit.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928599/

https://www.ncbi.nlm.nih.gov/pubmed/25837274

Arugula helps prevent cancer.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442471/

https://www.sciencedirect.com/science/article/pii/S0367326X11000657?via%3Dihub

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065051/

http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:26745094&key=2015.16.18.8411

High in antioxidants so it improves skin barrier function.

https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.5138

It contains Isorhamnetin which is also found in onions and other spices. It is renoprotective.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840710/

Phytochemicals

https://pubs.acs.org/doi/abs/10.1021/jf052756t

https://www.ncbi.nlm.nih.gov/pubmed/17590871

https://www.ncbi.nlm.nih.gov/pubmed/27816826

https://www.ncbi.nlm.nih.gov/pubmed/22369966

It chelates the bad iron from the body and reduces reactive oxygen species.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701420/

It inhibits urease which would help with gastric ulcers. It would also help lower ammonia levels in the body.

http://journals.sagepub.com/doi/abs/10.1177/2156587214527452?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675085/

Reduces Quinone which would help with sepsis, detox issues, a leaky blood brain barrier and hormone issues.

https://www.ncbi.nlm.nih.gov/pubmed/27523193

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312139/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241708/

Would help protect from vaccine injury and other toxins. Protects the thyroid.

https://www.ncbi.nlm.nih.gov/pubmed/17207565

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153205/

https://link.springer.com/article/10.1007%2Fs11356-017-8671-8

http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:26320454&key=2015.16.14.5801

https://www.ncbi.nlm.nih.gov/pubmed/28913779

It is high in Erucin

https://www.ncbi.nlm.nih.gov/pubmed/27087163

Helps with diabetes.

https://www.karger.com/Article/Abstract/12829

https://www.tandfonline.com/doi/full/10.1080/13880209.2017.1280687

Reduces inflammation because it is high in isothiocyanites.

https://www.ncbi.nlm.nih.gov/pubmed/22453842

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037733/

Yarrow

 

 

 

Achillea Millefolium

This is for educational and informational purposes and should not be taken as medical advice. If in doubt don’t. If you do not know a plant well do not use it.

I do not like the taste of Yarrow but I do know eating it has had noticeable effects. I noticed I had increased energy levels. There are sites that claim it lowers blood pressure but my friends who had hypertension experienced a rise in their blood pressure when they used Yarrow. Has has been used for many illnesses even hemorrhoids. There are claims that when applied to wounds it stops bleeding. There are many species of Achillea but I am fimiliar with A. Millefolium. The others  chemical makeup is very similar.

https://www.ediblewildfood.com/common-yarrow.aspx

https://wellnessmama.com/7106/yarrow-herb-profile/

It’s effects on cancer.

https://www.ncbi.nlm.nih.gov/pubmed/29883784

Speeds up healing.

https://www.ncbi.nlm.nih.gov/pubmed/29731432

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610620/

Contains Achillolide A which prevents amyloid plaque build up and would help with Alzheimer. Achillolide A has many benefits.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960475/

Achillolide A reduces reactive oxygen species.

https://www.researchgate.net/publication/296602862_Achillolide_A_Protects_Astrocytes_against_Oxidative_Stress_by_Reducing_Intracellular_Reactive_Oxygen_Species_and_Interfering_with_Cell_Signaling

Yarrow helps with diabetes by increasing insulin sensitivity.

https://www.ncbi.nlm.nih.gov/pubmed/29031783

Reduces anxiety

https://www.sciencedirect.com/science/article/pii/S0378874111008567?via%3Dihub

They claim it reduces blood pressure through it’s diuretic properties but I have seen it increase peoples blood pressure. One thing I did notice the ones it increased blood pressure in did not drink adequate amount of water.

https://www.ncbi.nlm.nih.gov/pubmed/23791807

Improves cognitive abilities, prevents strokes, reduces oxidative stress, reduces symptoms of MS, and helps with neurodegenerative disorders.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569446/

Phytochemicals

https://www.ncbi.nlm.nih.gov/pubmed/15688780

http://www.actabp.pl/pdf/2_2011/203.pdf

has antimicrobial properties.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590066/

Only way to describe this is it enhances the immune system.

https://www.ncbi.nlm.nih.gov/pubmed/27083352

Reduces pain

https://www.ncbi.nlm.nih.gov/pubmed/26238568

Appears to kill pain without no toxicity.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686861/

Can cause problems in those with high glutathione levels. This study is viewed as negative but it appears by their results it reduce quinone and would help with interstitial cystitis. If I had time I would get into more detail and explain why.

https://www.ncbi.nlm.nih.gov/pubmed/25870009

Helps with diabetes by protecting pancreatic cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293613/

Reduces oxalates so would help with high oxalate levels and stone formation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290053/

It is effective against the New Castle Disease Virus and other infections.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138681/

https://www.ncbi.nlm.nih.gov/pubmed/12860311

Is neuroprotective, protects the brain.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071708/

Has antispasmodic effects.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847392/

Inhibits histamine H1 receptors and muscarinic receptor.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831720/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608287/

This is what I notice in the other study and why I said it would help with interstitial cystitis. It has NO scavenging abilities. The also would help with kidney disease were people have excessive bleeding.

https://www.ncbi.nlm.nih.gov/pubmed/22976260

How it helps with acid reflux or gastric irritation.

https://www.ncbi.nlm.nih.gov/pubmed/22151891

https://www.ncbi.nlm.nih.gov/pubmed/20420892

https://www.ncbi.nlm.nih.gov/pubmed/19093480

How it helps with asthma and hypertension

https://www.ncbi.nlm.nih.gov/pubmed/20857434

Is a calcium channel blocker. This would help with things like high blood pressure, and other circulatory disorders.

https://www.ncbi.nlm.nih.gov/pubmed/16619341

Yarrow stimulates bile production so would help with constipation and gall bladder issues.

https://www.ncbi.nlm.nih.gov/pubmed/16303291